Dendritic cell-activated chimeric antigen receptor and its use

JP7863565B2Active Publication Date: 2026-05-21SHENZHEN FRONTIERGATE BIOTECHNOLOGY CO LTD +1
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Patent Information

Application Number
JP2023541498
Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
Priority Date
2021-01-08
Filing Date
2021-12-24
Publication Date
2026-05-21
Estimated Expiration
2041-12-24

AI Technical Summary

Technical Problem

Tumor-infiltrating dendritic cells (TIDCs) exhibit immature or dysfunctional phenotypes in immunosuppressive tumor microenvironments, suppressing T-cell infiltration and activation, and existing methods to activate them have not been effectively translated into clinical applications.

Method used

A chimeric antigen receptor (CAR) is designed to include an extracellular antigen-binding domain, a transmembrane domain, and an intracellular signaling domain to activate dendritic cells in immunosuppressive tumor microenvironments, comprising specific immunoinhibitory molecule targets and immunostimulatory cytokines, and is expressed in dendritic cells or their precursors using vectors like lentiviral vectors.

Benefits of technology

The CAR-activated dendritic cells enhance T-cell activation and immune response efficacy, particularly in tumors less responsive to CAR-T monotherapy, promoting immunostimulatory cytokine secretion and improved tumor cell recognition and elimination.

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Abstract

Provided are chimeric antigen receptors (CARs) for activating dendritic cells (DCs) in an immunosuppressive tumor environment. Also provided are compositions comprising the CARs, polynucleotides encoding the CARs, vectors comprising polynucleotides encoding the CARs, engineered cells comprising the CARs, and methods of using the CARs.
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Citation Information

Patent Citations

  • Chimeric antigen receptor, vector, human dendritic cell, cell line, solid tumor treatment medicine, preparation method and application

    CN112830974A

  • Modified monocytes / macrophages expressing chimeric antigen receptors and uses thereof

    JP2018521667A