Multispecific antibodies, multispecifically activatable antibodies, and methods for using them.

Multispecific antibodies with masking moieties address the limitations of monoclonal antibodies by selectively targeting multiple disease-related antigens and activating immune cells at disease sites, enhancing therapeutic efficacy and reducing side effects.

JP7873695B2Active Publication Date: 2026-06-12CYTOMX THERAPEUTICS INC
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
CYTOMX THERAPEUTICS INC
Filing Date
2024-03-28
Publication Date
2026-06-12

AI Technical Summary

⚠Technical Problem

Monoclonal antibodies often fail to effectively target multiple disease-related targets due to limited therapeutic efficacy and broad target expression, leading to toxicity and rapid clearance from circulation.

⚗Method used

Development of multispecific antibodies and activatable antibodies with masking moieties that reduce antigen-binding in normal tissues, allowing targeted activation and enhanced selectivity at disease sites, mobilizing immune effector cells like T cells and NK cells.

🎯Benefits of technology

Enhances therapeutic efficacy by selectively targeting multiple antigens or epitopes while minimizing side effects, activating immune cells at disease sites, and reducing autoreactive responses.

✦ Generated by Eureka AI based on patent content.

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Patent Text Reader

Abstract

To provide multispecific antibodies and multispecific activatable antibodies that specifically bind to multiple different antigens or epitopes, and methods of making and using these multispecific antibodies and / or multispecific activatable antibodies in a variety of therapeutic, diagnostic and prophylactic applications.SOLUTION: The present invention provides multispecific activatable antibodies that are multispecific antibodies that include at least one masking moiety (MM) linked to at least one antigen- or epitope-binding domain of the multispecific antibody such that coupling of the MM reduces the ability of the antigen- or epitope-binding domain to bind its target.SELECTED DRAWING: None
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