LN-isobutyrylcysteine ​​(L-NIBC) bound gold cluster Au18(L-NIBC)14, its composition and use

L-NIBC-conjugated gold cluster molecules, particularly Au 18(L-NIBC) 14, are characterized and purified for effective pharmaceutical use, addressing the variability in gold clusters to treat multiple sclerosis, Alzheimer's disease, cirrhosis, diabetes mellitus, and Parkinson's disease.

JP7876224B2Active Publication Date: 2026-06-19SHENZHEN PROFOUND VIEW PHARMA TECH CO LTD
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Patent Information

Application Number
JP2024543134
Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
Filing Date
2022-01-20
Publication Date
2026-06-19
Estimated Expiration
2042-01-20

AI Technical Summary

Technical Problem

The variability in the number of gold atoms and ligands in gold clusters complicates the identification of specific gold cluster molecules with therapeutic potential, limiting their application in drug development for diseases such as multiple sclerosis, Alzheimer's disease, cirrhosis, diabetes mellitus, and Parkinson's disease.

Method used

The development of L-N-isobutyrylcysteine (L-NIBC)-conjugated gold cluster molecules, specifically Au 18(L-NIBC) 14, which are characterized and purified to a high degree of purity, enabling their use in pharmaceutical compositions for treating these diseases.

Benefits of technology

The Au 18(L-NIBC) 14 molecules demonstrate significant therapeutic effects in animal models of multiple sclerosis, Alzheimer's disease, cirrhosis, diabetes mellitus, and Parkinson's disease, improving clinical scores and reducing disease symptoms.

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Abstract

LN-isobutyrylcysteine ​​(L-NIBC)-bound gold cluster Au 18 (L-NIBC) 14 , multiple sclerosis, Alzheimer's disease (AD), cirrhosis of the liver, diabetes, Parkinson's disease (PD), or glaucoma, and its use for the manufacture of a medicament for the treatment of multiple sclerosis, Alzheimer's disease (AD), cirrhosis of the liver, diabetes, Parkinson's disease (PD), or glaucoma. Compositions and methods for treating multiple sclerosis, Alzheimer's disease (AD), cirrhosis of the liver, diabetes, Parkinson's disease (PD), or glaucoma.
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Citation Information

Patent Citations

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