Method for preparing anidurafungin derivatives

The preparation of anidurafungin derivatives via targeted reactions addresses the limitations of current antifungal drugs, providing safer and more effective treatment options with enhanced antifungal activity and reduced allergic reactions.

JP7877364B2Active Publication Date: 2026-06-22SHANGHAI SENHUI MEDICINE CO LTD +2
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Patent Information

Application Number
JP2023573153
Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
Priority Date
2021-06-03
Filing Date
2022-06-02
Publication Date
2026-06-22
Estimated Expiration
2042-06-02

AI Technical Summary

Technical Problem

Current antifungal drugs face limitations such as infusion-related reactions, nephrotoxicity, development of drug-resistant strains, and narrow activity spectrum, necessitating the need for safer and more effective alternatives.

Method used

A method for preparing anidurafungin derivatives through specific reactions involving anidurafungin with compounds like phenylboronic acid and acids such as camphorsulfonic acid, in solvents like anhydrous dioxane, to enhance antifungal activity.

Benefits of technology

The prepared anidurafungin derivatives demonstrate strong antifungal activity with reduced toxicity and lower histamine release, indicating potential for safer clinical use.

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Abstract

The present disclosure relates to a process for preparing anidulafungin derivatives, particularly to a process for preparing anidulafungin derivatives represented by formula (I) and intermediates thereof. JPEG2024520500000021.jpg82170
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Citation Information

Patent Citations

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    JP2014516339A

  • Dosage regimens for echinocandin compounds

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  • Echinocandin analogs and methods for their preparation

    JP2023504389A