Transparent composition containing polyhydroxy acids

Abstract

To provide a transparent composition which can reduce stickiness brought and reduce skin discomfort such as reduction of skin irritation even if the composition contains a relatively large amount of a polyhydroxy acid or its salt when the composition is applied to the skin.SOLUTION: There is provided a transparent composition which comprises (a) at least one first compound selected from a polyhydroxy acid and its salt, (b) at least one second compound selected from vitamin B3 and its derivative, (c) at least one alkylene oxide derivative represented by a specific chemical formula and (d) water, wherein the amount of the first compound (a) in the composition is 1 mass% or more, preferably 3 mass% or more and more preferably 5 mass% or more based on the total mass of the composition.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a composition containing a relatively large amount of polyhydroxy acid, preferably a cosmetic composition. [Background technology]

[0002] Peeling is a well-known method for improving the appearance of the skin surface, particularly for treating visible and / or tactile irregularities in human skin, such as reducing pigmentation issues like freckles or scars from acne or chickenpox, or smoothing out irregularities in skin texture, especially wrinkles or fine lines.

[0003] This peeling treatment removes the portion of the skin to be treated (the epidermis and, if applicable, the upper layer of the dermis) by chemical means, for example, by applying a composition containing a peeling agent that stimulates skin exfoliation, such as an alpha-hydroxy acid (AHA) like glycolic acid, or a beta-hydroxy acid (BHA) like salicylic acid, or other active substances such as retinoic acid, resorcinol, trichloroacetic acid, or phenol. [Prior art documents] [Patent Documents]

[0004] [Patent Document 1] U.S. Patent No. 5,364,633(A) [Patent Document 2] U.S. Patent No. 5411744(A) [Non-patent literature]

[0005] [Non-Patent Document 1] Article by Meylan and Howard: Atom / Fragment contribution method for estimating octanol-water partition coefficients, J. Pharm. Sci., 84: pp. 83-92, 1995. [Non-Patent Document 2] Exploring QSAR: hydrophobic, electronic and steric constants (ACS professional reference book, 1995) [Non-Patent Document 3] http: / / esc.syrres.com / interkow / kowdemo.htm [Non-Patent Document 4] Walter Noll's Chemistry and Technology of Silicones (1968), Academic Press [Non-Patent Document 5] Cosmetics and Toiletries, Vol. 91, January 1976, pp. 27-32, Todd & Byers, Volatile Silicone Fluids for Cosmetics [Non-Patent Document 6] Satoshi Tomomasa et al., Oil Chemistry, Vol. 37, No. 11 (1988), pp. 48-53. [Overview of the project] [Problems that the invention aims to solve]

[0006] Polyhydroxy acids (PHAs) and their salts are also useful as peeling agents. Generally, PHAs have a larger molecular size than AHAs. Therefore, when applied to the skin, PHAs tend not to penetrate as deeply as AHAs. Consequently, PHAs are generally preferred because they are less irritating, especially on sensitive skin.

[0007] However, it has been found that using a relatively large amount of PHA in a composition can cause the composition to become sticky and irritate the skin when applied. Adding a considerable amount of oil to the composition can reduce the stickiness. However, compositions containing a considerable amount of oil will no longer be transparent. Transparency is sometimes important in consumer products such as cosmetics that contain skin peeling compositions.

[0008] The object of the present invention is to provide a transparent composition that, when applied to the skin, reduces stickiness and skin discomfort, such as reduced skin irritation, even when the composition contains a relatively large amount of polyhydroxy acid or its salt. [Means for solving the problem]

[0009] The object of the present invention described above is, (a) at least one first compound selected from polyhydroxy acids and their salts, (b) at least one second compound selected from vitamin B3 and its derivatives, (c) The following chemical formula (I): Z-{O(AO) l (EO) m -(BO) n H} a (I) [In the formula, Z represents a residue obtained by removing hydroxyl groups from a compound having 3 to 9 hydroxyl groups. AO represents an oxyalkylene group having 3 to 4 carbon atoms. EO indicates an oxyethylene group. BO represents an oxyalkylene group having four carbon atoms. 'a' represents 3-9, l, m, and n represent the average number of moles added of AO, EO, and BO, respectively, with 1 ≤ l ≤ 50, 1 ≤ m ≤ 50, and 0.5 ≤ n ≤ 5. The mass ratio of AO to EO (AO / EO) is in the range of 1 / 5 to 5 / 1. AO and EO may be added randomly or in block form. At least one alkylene oxide derivative represented by, and (d) water A transparent composition comprising, (a) The amount of the first compound in the composition is 1% by mass or more, preferably 3% by mass or more, and more preferably 5% by mass or more, based on the total mass of the composition. This can be achieved by composition.

[0010] (a) The first compound may be in the form of a lactone.

[0011] (a) The first compound may be a gluconolactone.

[0012] The amount of (a) the first compound in the composition according to the present invention may be 1% to 20% by mass, preferably 3% to 15% by mass, and more preferably 5% to 10% by mass, based on the total mass of the composition.

[0013] (b) The second compound may be a niacinamide.

[0014] The amount of (b) the second compound in the composition according to the present invention may be 1% to 20% by mass, preferably 2% to 15% by mass, and more preferably 3% to 10% by mass, based on the total mass of the composition.

[0015] (c) Alkylene oxide derivatives have the following chemical formula (II): Gly-{O(PO) s (EO) t -(BO) u H}3(II) [In the formula, Gly refers to the residue obtained by removing the hydroxyl group from glycerol. PO indicates an oxypropylene group. EO indicates an oxyethylene group. s and t represent the average number of moles added to PO and EO, respectively, and have values ​​within the range of 1 to 50. The mass ratio of PO to EO (PO / EO) is in the range of 1 / 5 to 5 / 1. BO represents an oxyalkylene group having four carbon atoms. [u represents the average number of moles added to BO, and is in the range of 0.5 to 5.] It can be represented by [this].

[0016] (c) The alkylene oxide derivative may be PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerin.

[0017] The amount of (c) alkylene oxide derivative in the composition according to the present invention may be 0.1% to 12% by mass, preferably 0.5% to 10% by mass, and more preferably 1% to 8% by mass, based on the total mass of the composition.

[0018] The composition according to the present invention may further contain (e) at least one oil in an amount of 1% by mass or less, preferably 0.1% by mass or less, and more preferably 0.01% by mass or less, based on the total mass of the composition.

[0019] The compositions according to the present invention are selected from alpha-hydroxy acids, beta-hydroxy acids, phytic acids, and mixtures thereof, and may further contain (a) a compound different from the first compound, and (f) at least one additional compound.

[0020] The amount of (f) the additional compound in the composition according to the present invention may be 0.001% to 5% by mass, preferably 0.01% to 4% by mass, and more preferably 0.05% to 3% by mass, relative to the total mass of the composition.

[0021] The composition according to the present invention may be a cosmetic composition, preferably a skin cosmetic composition, and more preferably a skin peeling composition.

[0022] The present invention also relates to a cosmetic method for treating a keratinous substance, preferably for treating skin, and more preferably for peeling skin, the method comprising the step of applying a composition according to the present invention to a keratinous substance.

[0023] The present invention also relates to a use for reducing skin discomfort such as stickiness and skin irritation caused by a composition when the composition is applied to the skin, (a) at least one first compound selected from polyhydroxy acids and their salts, and (d) water in a composition comprising (b) at least one second compound selected from vitamin B3 and its derivatives, and (c) the following chemical formula (I): Z-{O(AO) l (EO) m -(BO) n H} a (I) [wherein, Z represents a residue obtained by removing a hydroxyl group from a compound having 3 to 9 hydroxyl groups, AO represents an oxyalkylene group having 3 to 4 carbon atoms, EO represents an oxyethylene group, BO represents an oxyalkylene group having 4 carbon atoms, a represents 3 to 9, l, m and n each represent the average addition molar number of AO, EO and BO, and 1≦l≦50, 1≦m≦50, 0.5≦n≦5, The mass ratio of AO to EO (AO / EO) is within the range of 1 / ?5 to?5 / 1, AO and EO may be added randomly or in block form] at least one alkylene oxide derivative represented by in combination with where the amount of the (a) first compound in the composition is at least 1% by mass, preferably at least 3% by mass, more preferably at least 5% by mass based on the total mass of the composition, also relates to the use.

Embodiments for Carrying Out the Invention

[0024] As a result of diligent research, the inventors have discovered that it is possible to provide a transparent composition that, when applied to the skin, reduces stickiness and minimizes skin discomfort such as skin irritation, even when the composition contains a relatively large amount of polyhydroxy acid or its salt.

[0025] Therefore, one aspect of the present invention is: (a) at least one first compound selected from polyhydroxy acids and their salts, (b) at least one second compound selected from vitamin B3 and its derivatives, (c) The following chemical formula (I): Z-{O(AO) l (EO) m -(BO) n H} a (I) [In the formula, Z represents a residue obtained by removing hydroxyl groups from a compound having 3 to 9 hydroxyl groups. AO represents an oxyalkylene group having 3 to 4 carbon atoms. EO indicates an oxyethylene group. BO represents an oxyalkylene group having four carbon atoms. 'a' represents 3-9, l, m, and n represent the average number of moles added of AO, EO, and BO, respectively, with 1 ≤ l ≤ 50, 1 ≤ m ≤ 50, and 0.5 ≤ n ≤ 5. The mass ratio of AO to EO (AO / EO) is in the range of 1 / 5 to 5 / 1. AO and EO may be added randomly or in block form. At least one alkylene oxide derivative represented by, and (d) water A composition comprising, The composition is such that (a) the amount of the first compound in the composition is 1% by mass or more, preferably 3% by mass or more, and more preferably 5% by mass or more, based on the total mass of the composition.

[0026] The composition according to the present invention is transparent.

[0027] The composition according to the present invention is less sticky, even though it contains a relatively large amount of polyhydroxy acid or its salt, i.e., 1% by mass or more, preferably 3% by mass or more, and more preferably 5% by mass or more, relative to the total mass of the composition. Therefore, it can provide a less sticky feel.

[0028] In this context, the term "sticky" refers to the characteristic of giving the skin a tacky feeling.

[0029] Therefore, the composition according to the present invention can provide an excellent feel, in particular, an excellent skin feel after application of the composition.

[0030] The composition according to the present invention can reduce skin discomfort. Skin discomfort, in this context, refers to discomfort unrelated to texture such as stickiness. Examples of discomfort include stinging, burning, and irritation.

[0031] Skin discomfort includes skin irritation. Therefore, the compositions according to the present invention can reduce skin irritation. In other words, the compositions according to the present invention can be gentle on the skin.

[0032] The composition according to the present invention can reduce the risk of skin inflammation.

[0033] Therefore, the composition according to the present invention is transparent, and when applied to the skin, it reduces stickiness and skin discomfort, such as reduced skin irritation, despite the composition containing a relatively large amount of polyhydroxy acid or its salt.

[0034] The composition according to the present invention is useful for peeling off the stratum corneum or the stratum corneum from the skin.

[0035] The composition according to the present invention can provide cosmetic effects such as exfoliation and improvement of skin condition, including skin smoothing, improvement of skin tone and whitening, reduction of blemishes, pores and blackheads, with respect to both the appearance and feel of the skin.

[0036] The compositions according to the present invention will be described in more detail below.

[0037] [Polyhydroxy acids] The compositions according to the present invention comprise (a) at least one first compound selected from polyhydroxy acids and salts thereof. If two or more first compounds are used, they may be the same or different.

[0038] The term "polyhydroxy acid" here refers to an organic compound having at least one carboxyl group and multiple hydroxyl groups. The number of carboxyl groups in a polyhydroxy acid is not limited, but one or two carboxyl groups are preferred, and one carboxyl group is more preferred. The number of hydroxyl groups in a polyhydroxy acid is also not limited, but two to ten are preferred, and two to six are more preferred. The number of carbon atoms in a polyhydroxy acid is not limited, but three to eleven are preferred, and three to eight are more preferred.

[0039] The above organic compounds may be aliphatic or aromatic. In other words, the polyhydroxy acid can be selected from aliphatic polyhydroxy acids or aromatic polyhydroxy acids. The aliphatic polyhydroxy acid is preferably selected from sugar acids.

[0040] Examples of polyhydroxy acids include dihydroxypropanoic acid, e.g., glyceric acid; trihydroxybutanoic acid, e.g., erythronic acid and threonic acid; tetrahydroxypentanoic acid, e.g., ribonic acid, arabinonic acid, xylonic acid and lyxonic acid; pentahydroxyhexanoic acid, e.g., aronic acid, altronic acid, gluconic acid, mannonic acid, guronic acid, idonic acid, galactonic acid and talonic acid; hexahydroxyheptanoic acid, e.g., glucoheptanoic acid and galactoheptonic acid; tartaric acid; lactobionic acid, maltobionic acid, and mixtures thereof.

[0041] (a) The first compound is preferably in the form of a lactone. The lactone ring of the first compound (a) in the form of a lactone may be saturated. Examples of the first compound (a) include gluconolactone, ribonolactone, and mixtures thereof.

[0042] (a) The first compound is more preferably a gluconolactone.

[0043] The type of salt is not limited. Examples of salts include alkali metal salts, e.g., sodium and potassium salts; alkaline earth metal salts, e.g., calcium and magnesium salts; zinc salts; iron salts; ammonium salts; amine salts, e.g., monoethanolamine salts, diethanolamine salts, and triethanolamine salts; and mixtures thereof. Sodium salts are preferred. If two or more salts are used, they may be the same or different.

[0044] The amount of (a) the first compound in the composition according to the present invention is 1% by mass or more, preferably 3% by mass or more, and more preferably 5% by mass or more, based on the total mass of the composition.

[0045] On the other hand, the amount of (a) the first compound in the composition according to the present invention may be 20% by mass or less, preferably 15% by mass or less, and more preferably 10% by mass or less, based on the total mass of the composition.

[0046] The amount of (a) the first compound in the composition according to the present invention may be 1% to 20% by mass, preferably 3% to 15% by mass, and more preferably 5% to 10% by mass, based on the total mass of the composition.

[0047] [Vitamin B3 and its derivatives] The composition according to the present invention comprises (b) at least one second compound selected from vitamin B3 and its derivatives. If two or more second compounds are used, they may be the same or different.

[0048] Vitamin B3, also known as vitamin PP, is expressed by the following formula:

[0049] [ka]

[0050] [In the formula, R may be a compound of -CONH2 (niacinamide), -COOH (nicotinic acid or niacin), CH2OH (nicotinyl alcohol), -CO-NH-CH2-COOH (nicotinuric acid), or -CO-NH-OH (nicotinylhydroxamic acid)]. Niacinamide is preferred.

[0051] Examples of vitamin B3 derivatives include nicotinic acid esters, such as tocopherol nicotinate, amides derived from niacinamide by substitution of the -CONH2 hydrogen group, products from the reaction of carboxylic acids and amino acids, and esters of nicotinyl alcohol with carboxylic acids, such as acetic acid, salicylic acid, glycolic acid, or palmitic acid.

[0052] The following derivatives may also be listed: 2-chloronicotinamide, 6-methylnicotinamide, 6-aminonicotinamide, N-methylnicotinamide, N,N-dimethylnicotinamide, N-(hydroxymethyl)nicotinamide, quinolinimide, nicotinanilide, N-benzylnicotinamide, N-ethylnicotinamide, nifenazone, nicotinaldehyde, isonicotinic acid, methylisonicotinic acid, thionicotinamide, niaramide, 2-mercaptonicotinic acid, nicomole and niaprazine, methyl nicotinate, and sodium nicotinate.

[0053] Other vitamin B3 derivatives that can be mentioned include inorganic salts such as chlorides, bromides, iodides, or carbonates, and organic salts such as those obtained by reaction with carboxylic acids, such as acetates, salicylates, glycolates, lactates, malates, citrates, mandelates, and tartrates.

[0054] (b) The second compound selected from vitamin B3 and its derivatives preferably has a log P of -0.7 to 6, preferably -0.5 to 4.

[0055] The log P value is the base-10 logarithm of the apparent partition coefficient of octanol-1-ol / water. The log P value is publicly known and is determined by standard tests that determine the concentrations of (b) the second compound in octanol-1-ol and in water. log P can be calculated by the method described in the article by Meylan and Howard: Atom / Fragment contribution method for estimating octanol-water partition coefficients, J. Pharm. Sci., 84: 83-92, 1995. This value may also be calculated using a number of commercially available software packages that determine log P as a function of the molecular structure. An example is the Epiwin software from the U.S. Environmental Protection Agency.

[0056] This value can be calculated using, in particular, the ACD (Advanced Chemistry Development) Solaris software V4.67, or it can be obtained from Exploring QSAR: hydrophobic, electronic, and steric constants (ACS professional reference book, 1995). There are also websites that provide approximate values ​​(address: http: / / esc.syrres.com / interkow / kowdemo.htm).

[0057] (b) The second compound is more preferably a niacinamide.

[0058] The amount of (b) the second compound in the composition according to the present invention may be 1% by mass or more, preferably 2% by mass or more, and more preferably 3% by mass or more, based on the total mass of the composition.

[0059] On the other hand, the amount of (b) the second compound in the composition according to the present invention may be 20% by mass or less, preferably 15% by mass or less, and more preferably 10% by mass or less, based on the total mass of the composition.

[0060] The amount of (b) the second compound in the composition according to the present invention may be 1% to 20% by mass, preferably 2% to 15% by mass, and more preferably 3% to 10% by mass, based on the total mass of the composition.

[0061] [Alkylene oxide derivatives] The composition according to the present invention comprises (c) at least one alkylene oxide derivative. If two or more alkylene oxide derivatives are used, they may be the same or different.

[0062] (c) Alkylene oxide derivatives have the following chemical formula (I): Z-{O(AO) l (EO) m -(BO) n H} a (I) [In the formula, Z represents a residue obtained by removing hydroxyl groups from a compound having 3 to 9 hydroxyl groups. AO represents an oxyalkylene group having 3 to 4 carbon atoms. EO indicates an oxyethylene group. BO represents an oxyalkylene group having four carbon atoms. 'a' represents 3-9, l, m, and n represent the average number of moles added of AO, EO, and BO, respectively, with 1 ≤ l ≤ 50, 1 ≤ m ≤ 50, and 0.5 ≤ n ≤ 5. The mass ratio of AO to EO (AO / EO) is in the range of 1 / 5 to 5 / 1. AO and EO may be added randomly or in block form. It is represented by [this].

[0063] In the alkylene oxide derivative represented by formula (I), Z represents a residue obtained by removing hydroxyl groups from a compound having 3 to 9 hydroxyl groups, and a represents the number of hydroxyl groups in the compound, ranging from 3 to 9. Examples of compounds having 3 to 9 hydroxyl groups include, for example, glycerin and trimethylolpropane when a=3, erythritol, pentaerythritol, sorbitol, alkyl glycosides and diglycerin when a=4, xylitol when a=5, dipentaerythritol, sorbitol and inositol when a=6, sucrose and trehalose when a=8, maltitol when a=9, and mixtures thereof. Preferably, Z represents a residue obtained by removing hydroxyl groups from a compound having 3 to 6 hydroxyl groups, and a satisfies 3 ≤ a ≤ 6. Glycerin or trimethylolpropane are preferred as the compound having 3 to 9 hydroxyl groups, and glycerin is particularly preferred. When a ≤ 2, poor compatibility with oily components such as fats and oils occurs, and blend stability in oil-based formulations tends to be impaired. When a ≤ 10, stickiness occurs.

[0064] AO represents an oxyalkylene group having 3 to 4 carbon atoms. Examples thereof include, for example, an oxypropylene group, an oxybutylene group (an oxy-n-butylene group, an oxyisobutylene group, or an oxy-t-butylene group), an oxytrimethylene group, and an oxytetramethylene group. An oxypropylene group and an oxybutylene group are preferred, and an oxypropylene group is more preferred.

[0065] l represents the average number of moles of AO added, satisfying 1 ≦ l ≦ 50, preferably 2 ≦ l ≦ 20. m represents the average number of moles of EO added, satisfying 1 ≦ m ≦ 50, preferably 2 ≦ m ≦ 20. When l is 0, stickiness occurs. On the other hand, when l exceeds 50, the moisturizing effect decreases. In addition, when m is 0, the moisturizing effect decreases. On the other hand, when m exceeds 50, stickiness occurs.

[0066] The mass ratio of AO to EO (AO / EO) is within the range of 1 / 5 to 5 / 1, preferably within the range of 1 / 4 to 4 / 1. When AO / EO is less than 1 / 5, stickiness occurs. On the other hand, when AO / EO exceeds 5 / 1, the moisturizing feeling decreases. The order of addition of AO and EO is not particularly specified. AO and EO may be added randomly or in block form. In order to obtain an excellent effect of preventing skin roughness, AO and EO are preferably added randomly.

[0067] BO represents an oxyalkylene group having 4 carbon atoms. Examples thereof include, for example, an oxybutylene group (an oxy-n-butylene group, an oxy-isobutylene group, or an oxy-t-butylene group), an oxytetramethylene group, etc. An oxybutylene group is preferred.

[0068] n represents the average number of moles of BO added, satisfying 0.5 < n ≦ 5, preferably 0.8 ≦ n ≦ 3, more preferably 1 ≦ n ≦ 3. When n is less than 0.5, stickiness occurs. On the other hand, when n exceeds 5, the moisturizing effect decreases. In formula (I), (BO) n needs to be bonded to the terminal hydrogen atom.

[0069] Alkylene oxide derivatives represented by formula (I) can be produced by known methods. For example, alkylene oxide derivatives represented by formula (I) can be obtained by addition polymerization of ethylene oxide and an alkylene oxide having 3 to 4 carbon atoms to a compound having 3 to 9 hydroxyl groups, followed by reaction with an alkylene oxide having 4 carbon atoms. When ethylene oxide and an alkylene oxide having 3 to 4 carbon atoms are added to a compound having 3 to 9 hydroxyl groups, the ethylene oxide and alkylene oxide can be polymerized randomly or in block form.

[0070] Among the alkylene oxide derivatives represented by formula (I), a preferred example of the aforementioned alkylene oxide derivative is, for example, the one shown below in formula (II): Gly-{O(PO) s (EO) t -(BO) u H}3(II) [In the formula, Gly refers to the residue obtained by removing the hydroxyl group from glycerol. PO indicates an oxypropylene group. EO indicates an oxyethylene group. s and t represent the average number of moles added to PO and EO, respectively, and have values ​​within the range of 1 to 50. The mass ratio of PO to EO (PO / EO) is in the range of 1 / 5 to 5 / 1. BO represents an oxyalkylene group having four carbon atoms. [u represents the average number of moles added to BO, and is in the range of 0.5 to 5.] Examples include alkylene oxide derivatives represented by (polyoxybutylene polyoxyethylene polyoxypropylene glycerol).

[0071] The alkylene oxide derivative represented by formula (II) can be obtained by adding propylene oxide and ethylene oxide to glycerin in a ratio of 3 to 150 molar equivalents of propylene oxide and ethylene oxide relative to glycerin, and then adding an alkylene oxide having 4 carbon atoms in a ratio of 1.5 to 15 molar equivalents relative to glycerin.

[0072] When adding the aforementioned alkylene oxide to glycerin, the addition reaction is carried out using an alkaline catalyst, a phase-transfer catalyst, or a Lewis acid catalyst. Generally, an alkaline catalyst such as potassium hydroxide is preferably used.

[0073] Among the alkylene oxide derivatives represented by formula (I), more preferred derivatives are obtained by adding 6 to 10 moles of ethylene oxide and 3 to 7 moles of propylene oxide to glycerin, followed by the addition of 2 to 4 moles of butylene oxide.

[0074] Among the alkylene oxide derivatives represented by formula (I), a more preferred derivative is polyoxybutylene polyoxyethylene polyoxypropylene glycerol, which is obtained by adding 8 mol of ethylene oxide and 5 mol of propylene oxide to glycerin, followed by the addition of 3 mol of butylene oxide, and has the INCI name PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerin. PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerin is commercially available from NOF Corporation under the trade name WILBRIDE S-753.

[0075] The amount of (c) alkylene oxide derivative in the composition according to the present invention may be 0.1% by mass or more, preferably 0.5% by mass or more, and more preferably 1% by mass or more, based on the total mass of the composition.

[0076] On the other hand, the amount of (c) alkylene oxide derivative in the composition according to the present invention may be 12% by mass or less, preferably 10% by mass or less, and more preferably 8% by mass or less, based on the total mass of the composition.

[0077] The amount of (c) alkylene oxide derivative in the composition according to the present invention may be 0.1% to 12% by mass, preferably 0.5% to 10% by mass, and more preferably 1% to 8% by mass, based on the total mass of the composition.

[0078] [water] The composition according to the present invention comprises (d) water.

[0079] The amount of (d) water in the composition according to the present invention may be 40% by mass or more, preferably 50% by mass or more, and more preferably 60% by mass or more, based on the total mass of the composition.

[0080] On the other hand, the amount of (d) water in the composition according to the present invention may be 90% by mass or less, preferably 80% by mass or less, and more preferably 70% by mass or less, based on the total mass of the composition.

[0081] The amount of (d) water in the composition according to the present invention may be 40% to 90% by mass, preferably 50% to 80% by mass, and more preferably 60% to 70% by mass, based on the total mass of the composition.

[0082] [oil] The composition according to the present invention may contain, in a limited amount, (e) at least one oil. If two or more oils are used, they may be the same or different.

[0083] Here, "oil" refers to fatty compounds or fatty substances that are in liquid or paste (non-solid) form at atmospheric pressure (760 mmHg) and room temperature (25°C). Oils commonly used in cosmetics can be used alone or in combination. These oils may be volatile or non-volatile.

[0084] (e) The oil may be a non-polar oil, such as a hydrocarbon oil or a silicone oil; a polar oil, such as a vegetable oil or an animal oil, and an ester oil or an ether oil; or a mixture thereof.

[0085] (e) The oil may be selected from the group consisting of plant or animal-derived oils, synthetic oils, silicone oils, hydrocarbon oils, and fatty alcohols.

[0086] Examples of vegetable oils include, for instance, linseed oil, camellia oil, macadamia nut oil, corn oil, mink oil, olive oil, avocado oil, camellia oil, castor oil, safflower oil, jojoba oil, sunflower oil, almond oil, rapeseed oil, grape seed oil, sesame oil, soybean oil, peanut oil, and mixtures thereof.

[0087] Examples of animal oils include, for instance, squalene and squalane.

[0088] Examples of synthetic oils include alkane oils, such as isododecane and isohexadecane, ester oils, ether oils, and artificial triglycerides.

[0089] Ester oils are preferably saturated or unsaturated linear or branched C1-C12 26 Aliphatic monoacid or polyacid and saturated or unsaturated linear or branched C1-C123 26 It is a liquid ester of an aliphatic monohydric alcohol or a polyhydric alcohol, and the total number of carbon atoms in these esters is 10 or more.

[0090] Preferably, in the case of a monohydric alcohol ester, at least one of the alcohol and acid from which the ester of the present invention is derived is branched.

[0091] Among monoesters of monoacids and monohydric alcohols, examples include ethyl palmitate, ethylhexyl palmitate, isopropyl palmitate, dicaprylyl carbonate, alkyl myristate, for example isopropyl myristate or ethyl myristate, isocetyl stearate, 2-ethylhexyl isononanoate, isononyl isononanoate, isodecyl neopentanoate, and isostearyl neopentanoate.

[0092] C4~C 22 Dicarboxylic acid or tricarboxylic acid and C1-C 22 Esters with alcohols, as well as monocarboxylic acids, dicarboxylic acids, or tricarboxylic acids, and nonsugars C4-C 26 Esters with dihydroxy, trihydroxy, tetrahydroxy, or pentahydroxy alcohols can also be used.

[0093] In particular, diethyl sebacate, isopropyl lauroyl sarcosinate, diisopropyl sebacate, bis(2-ethylhexyl) sebacate, diisopropyl adipate, di-n-propyl adipate, dioctyl adipate, bis(2-ethylhexyl) adipate, diisostearyl adipate, bis(2-ethylhexyl) maleate, triisopropyl citrate, triisocetyl citrate, triisostearyl citrate, glyceryl trilactic acid, glyceryl trioctanoate, trioctyldodecyl citrate, trioleyl citrate, neopentyl glycol diheptanoate, and diethylene glycol diisononanoate can be mentioned.

[0094] As ester oils, C6~C 30 Preferably C 12 ~C 22 Fatty acid sugar esters and diesters can be used. It should be noted that the term "sugar" refers to an oxygen-retaining hydrocarbon compound containing several alcoholic functional groups, having or not having aldehyde or ketone functional groups, and containing at least four carbon atoms. These sugars may be monosaccharides, oligosaccharides, or polysaccharides.

[0095] Examples of suitable sugars that can be listed include sucrose (or saccharose), glucose, galactose, ribose, fucose, maltose, fructose, mannose, arabinose, xylose, and lactose, as well as their derivatives, particularly alkyl derivatives, such as methyl derivatives, for example, methyl glucose.

[0096] Fatty acid sugar esters, in particular, consist of the aforementioned sugars and linear or branched saturated or unsaturated C6-C6 molecules. 30 Preferably C 12 ~C 22 The group can be selected from those containing esters or ester mixtures with fatty acids. When these compounds are unsaturated, they may have 1 to 3 conjugated or unconjugated carbon-carbon double bonds.

[0097] Esters in this modified form can also be selected from monoesters, diesters, triesters, tetraesters, and polyesters, as well as mixtures thereof.

[0098] These esters may be, for example, oleic acid esters, lauric acid esters, palmitic acid esters, myristic acid esters, behenic acid esters, coconut fatty acid esters, stearic acid esters, linoleic acid esters, linolenic acid esters, capric acid esters, and arachidonic acid esters, or mixtures thereof, for example, mixed esters of oleopalmitic acid, oleostearic acid, and palmitostearic acid, and pentaerythrityl tetraethylhexanoate.

[0099] More specifically, monoesters and diesters, particularly monooleates or dioleates, stearates, behenates, oleopalmitates, linoleates, linolenicates, and oleostearates of sucrose, glucose, or methyl glucose, are used.

[0100] One example that can be cited is the product sold by Amerchol under the name Glucate(registered trademark) DO, which is methyl glucose dioleate.

[0101] Examples of preferred ester oils include, for example, diisopropyl adipate, dioctyl adipate, 2-ethylhexyl hexanoate, ethyl laurate, cetyl octanoate, octyldodecyl octanoate, isodecyl neopentanoate, myristyl propionate, 2-ethylhexyl 2-ethylhexanoate, 2-ethylhexyl octanoate, 2-ethylhexyl caprylic / capric acid, methyl palmitate, ethyl palmitate, isopropyl palmitate, and dicaprate. Examples include lylyl, isopropyl lauroyl sarcosinate, isononyl isononanoate, ethylhexyl palmitate, isohexyl laurate, hexyl laurate, isocetyl stearate, isopropyl isostearate, isopropyl myristate, isodecyl oleate, glyceryl tri(2-ethylhexanoate), pentaerythrityl tetra(2-ethylhexanoate), ethylhexyl succinate, diethyl sebacate, and mixtures thereof.

[0102] Examples of artificial triglycerides include caprylcaprylyl glyceride, glyceryl trimyristicate, glyceryl tripalmitate, glyceryl trilinolenate, glyceryl trilaurate, glyceryl tricaprate, glyceryl tricaprylate, tri(caprate / caprylic acid)glyceryl, and tri(caprate / caprylic acid / linolenic acid)glyceryl.

[0103] Examples of silicone oils include, for example, linear organopolysiloxanes such as dimethylpolysiloxane, methylphenylpolysiloxane, and methylhydrogenpolysiloxane, cyclic organopolysiloxanes such as cyclohexasiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexasiloxane, and mixtures thereof.

[0104] Preferably, the silicone oil is selected from liquid polydialkylsiloxanes, particularly liquid polydimethylsiloxane (PDMS), and liquid polyorganosiloxanes containing at least one aryl group.

[0105] These silicone oils may also be organically modified. The organically modified silicones that can be used according to the present invention are the silicone oils defined above, which contain one or more organic functional groups linked in their structure via hydrocarbon groups.

[0106] Organopolysiloxanes are further defined in Walter Noll's *Chemistry and Technology of Silicones* (1968), Academic Press. Organopolysiloxanes may be volatile or non-volatile.

[0107] If volatile, the silicone is selected more specifically from those having a boiling point between 60°C and 260°C, and even more specifically from the following: (i) Cyclic polydialkylsiloxanes containing 3 to 7, preferably 4 to 5, silicon atoms. These include, for example, octamethylcyclotetrasiloxane, sold by Union Carbide under the name Volatile Silicone® 7207, or by Rhodia under the name Silbione® 70045 V2; decamethylcyclopentasiloxane, sold by Union Carbide under the name Volatile Silicone® 7158, sold by Rhodia under the name Silbione® 70045 V5; and dodecamethylcyclopentasiloxane, sold by Momentive Performance Materials under the name Silsoft 1217, as well as mixtures thereof. Other examples include cyclocopolymers of the type dimethylsiloxane / methylalkylsiloxane, such as Silicone Volatile® FZ 3109 sold by Union Carbide.

[0108] [ka]

[0109] Other examples include mixtures of cyclic polydialkylsiloxanes and organosilicon compounds, such as a mixture of octamethylcyclotetrasiloxane and tetratrimethylsilylpentaerythritol (50 / 50), and a mixture of octamethylcyclotetrasiloxane and oxy-1,1'-bis(2,2,2',2',3,3'-hexatrimethylsilyloxy)neopentane; and (ii) Contains 2 to 9 silicon atoms and has a temperature of 5 × 10 at 25°C -6 m 2Linear volatile polydialkylsiloxanes with a viscosity of less than 1 / s. An example is decamethyltetrasiloxane, sold by Toray Silicone under the name SH 200. Silicones belonging to this category are also described in the paper published in Cosmetics and Toiletries, Vol. 91, January 1976, pp. 27-32, by Todd & Byers, Volatile Silicone Fluids for Cosmetics. The viscosity of the silicones was measured at 25°C according to ASTM standard 445 Annex C.

[0110] Non-volatile polydialkylsiloxanes can also be used. These non-volatile silicones are selected more specifically from polydialkylsiloxanes, among which polydimethylsiloxanes having trimethylsilyl terminal groups are particularly noteworthy.

[0111] Among these polydialkylsiloxanes, the following commercially available products can be listed without limitation: - Silbione® oils 47 and 70 047 series, or Mirasil® oils sold by Rhodia, for example, 70 047 V 500 000 oil. - Mirasil® series oils sold by Rhodia, - Dow Corning's 200 series oil, for example, 60,000 mm 2 DC200 having a viscosity of / s; and - Viscasil® oil manufactured by General Electric and certain oils in the General Electric SF series (SF 96, SF 18).

[0112] Polydimethylsiloxanes containing dimethylsilanol terminal groups, known by the name dimethiconol (CTFA), such as the 48 series oils from Rhodia, can also be cited.

[0113] Among silicones containing aryl groups, examples include polydiarylsiloxanes, particularly polydiphenylsiloxanes and polyalkylarylsiloxanes, such as phenylsilicone oil.

[0114] Phenylsilicone oil has the following formula:

[0115] [ka]

[0116] [In the formula, R1~R 10 These are, independently of each other, saturated or unsaturated, linear, cyclic or branched C1-C12 30 Hydrocarbon groups, preferably C1-C 12 A hydrocarbon group, more preferably a C1-C6 hydrocarbon group, particularly a methyl, ethyl, propyl, or butyl group. m, n, p, and q are independent integers between 0 and 900, preferably between 0 and 500, and more preferably between 0 and 100, including both ends. However, the sum of n+m+q is non-zero. You can choose from phenyl silicones.

[0117] Examples that can be given include products sold under the following names: - Rhodia's Silbione® oil, 70 641 series. - Rhodorsil® 70 633 and 763 series oils manufactured by Rhodia, - Dow Corning 556 Cosmetic Grade Fluid, manufactured by Dow Corning. - Bayer's PK series silicones, for example, PK20 products, - Certain oils from General Electric's SF series, such as SF 1023, SF 1154, SF 1250, and SF 1265.

[0118] As phenyl silicone oil, phenyl trimethicone (in the above formula, R1 to R 10 (where is methyl, p, q, and n = 0, and m = 1 is preferred)

[0119] Organically modified liquid silicones may, in particular, contain polyethylene oxy and / or polypropylene oxy groups. Examples include the silicone KF-6017 proposed by Shin-Etsu Chemical Co., Ltd., and the oils Silwet® L722 and L77 manufactured by Union Carbide.

[0120] Hydrocarbon oils can be selected from the following: - Linear or branched, optionally cyclic C6-C 16 Lower alkanes. Examples that can be listed include hexane, undecane, dodecane, tridecane, and isoparaffins, including isohexadecane, isododecane, and isodecane; and - Linear or branched hydrocarbons containing more than 16 carbon atoms, such as liquid paraffin, liquid petroleum jelly, polydecene, and hydrogenated polyisobutene, such as Parleam®, and squalane.

[0121] Preferred examples of hydrocarbon oils include, for example, linear or branched hydrocarbons such as isohexadecane, isododecane, squalane, mineral oil (e.g., liquid paraffin), paraffin, petrolatum or petrolatum, and naphthalenes; hydrogenated polyisobutene, isoeicosane, and decene / butene copolymers, and mixtures thereof.

[0122] The term "fatty" in fatty alcohols means that they contain a relatively large number of carbon atoms. Therefore, alcohols having four or more, preferably six or more, and more preferably twelve or more carbon atoms are included in the range of fatty alcohols. Fatty alcohols may be saturated or unsaturated. Fatty alcohols may be linear or branched.

[0123] Fatty alcohols may have the structure R-OH [wherein R is selected from saturated and unsaturated, linear and branched groups containing 4 to 40 carbon atoms, preferably 6 to 30 carbon atoms, more preferably 12 to 20 carbon atoms]. In at least one embodiment, R is C 12 ~C 20 Alkyl alkyl groups, and C 12 ~C 20 It can be selected from alkenyl groups. R may or may not be substituted with at least one hydroxyl group.

[0124] Examples of fatty alcohols include lauryl alcohol, cetyl alcohol, stearyl alcohol, isostearyl alcohol, behenyl alcohol, undecylenyl alcohol, myristyl alcohol, octyldodecanol, hexyldecanol, oleyl alcohol, linoleyl alcohol, palmitrail alcohol, arachidonyl alcohol, erucyl alcohol, and mixtures thereof.

[0125] The fatty alcohol is preferably a saturated fatty alcohol.

[0126] Therefore, fatty alcohols are linear or branched, saturated or unsaturated C6-C6. 30 Alcohol, preferably linear or branched, saturated C6-C6 30 Alcohol, more preferably linear or branched, saturated C 12 ~C 20 You can choose from alcoholic beverages.

[0127] The term "saturated fatty alcohol" here refers to an alcohol having a long, aliphatic saturated carbon chain. Saturated fatty alcohols are any linear or branched, saturated C6-C6 alcohols. 30 It is preferable to select from fatty alcohols. Linear or branched saturated C6-C6 30 Among fatty alcohols, linear or branched saturated C2 is particularly important. 12 ~C 20Fatty alcohols may be preferably used. Any linear or branched saturated C 16 ~C 20 Fatty alcohols may be more preferably used. Branched C 16 ~C 20 Fatty alcohols may be used even more preferably.

[0128] Examples of saturated fatty alcohols include lauryl alcohol, cetyl alcohol, stearyl alcohol, isostearyl alcohol, behenyl alcohol, undecylenyl alcohol, myristyl alcohol, octyldodecanol, hexyldecanol, and mixtures thereof. In one embodiment, cetyl alcohol, stearyl alcohol, octyldodecanol, hexyldecanol, or mixtures thereof (e.g., cetearyl alcohol), and behenyl alcohol can be used as saturated fatty alcohols.

[0129] According to at least one embodiment, the fatty alcohol used in the composition according to the present invention is preferably selected from cetyl alcohol, octyldodecanol, hexyldecanol, and mixtures thereof.

[0130] (e) It is also preferable that the oil be selected from oils having a molecular weight of less than 600 g / mol.

[0131] Preferably, (e) the oil has a low molecular weight such as less than 600 g / mol and contains short-chain hydrocarbons (C1-C1). 12 Ester oils having (e.g., isopropyl lauroyl sarcosinate, isopropyl myristate, isopropyl palmitate, isononyl isononanoate, and ethylhexyl palmitate), silicone oils (e.g., volatile silicones such as cyclohexasiloxane), hydrocarbon oils (e.g., isododecane, isohexadecane, and squalane), branched and / or unsaturated fatty alcohols (C 12 ~C 30 The oil is selected from among ) type oils, such as octyldodecanol and oleyl alcohol, and ether oils such as dicaprylyl ether.

[0132] (e) The oil can be selected from polar oils, preferably from ester oils, more preferably from isopropyl myristate, and from non-polar oils, preferably from ether oils, more preferably from dicaprylyl ether.

[0133] The amount of (e) oil in the composition according to the present invention is preferably 1% by mass or less, more preferably 0.1% by mass or less, and even more preferably 0.01% by mass or less, based on the total mass of the composition.

[0134] The composition according to the present invention is most preferably oil-free.

[0135] However, the amount of (e) oil in the composition according to the present invention may be 0.001% by mass or more.

[0136] [Additional compounds] The compositions according to the present invention are selected from alpha-hydroxy acids, beta-hydroxy acids, phytic acids, and mixtures thereof, and may include (a) a compound different from the first compound, and (f) at least one additional compound. If two or more additional compounds are used, they may be the same or different.

[0137] The term "alpha-hydroxy acid" or "AHA" here refers to a carboxylic acid having at least one carboxyl group and at least one hydroxyl group separated by one carbon atom. In other words, an AHA is a carboxylic acid having at least one hydroxyl group on an adjacent (alpha) carbon atom.

[0138] The alpha-hydroxy acid can be selected from, for example, glycolic acid, lactic acid, malic acid, citric acid, mandelic acid, and mixtures thereof, preferably from glycolic acid, citric acid, and mixtures thereof, and more preferably from glycolic acid.

[0139] The term "beta-hydroxy acid" or "BHA" here refers to a carboxylic acid having at least one carboxyl group and at least one hydroxyl group separated by two carbon atoms.

[0140] The beta-hydroxy acid may also be salicylic acid.

[0141] (f) As additional compounds, it is preferable to use a combination of at least one alpha-hydroxy acid and at least one beta-hydroxy acid, more preferably a combination of glycolic acid and salicylic acid, along with phytonic acid.

[0142] It is well known that AHAs can activate proteases in the stratum corneum, thereby increasing the degradation of corneodesmosomes, while in the dermis, AHAs can promote collagen formation, which subsequently leads to skin exfoliation. In addition, AHAs have also been reported to reduce facial pores and blackheads, most likely by targeting enzyme activation and protein function related to sebum production.

[0143] It is well known that BHA adds keratolytic activity to the stratum corneum, promoting cell peeling and shedding. BHA also removes clogged pores by softening sebum. For these reasons, BHA is effective in improving exfoliation and is particularly effective for acne and oily skin types.

[0144] The amount of (f) the additional compound in the composition according to the present invention may be 0.001% by mass or more, preferably 0.01% by mass or more, and more preferably 0.05% by mass or more, based on the total mass of the composition.

[0145] On the other hand, the amount of (f) additional compound in the composition according to the present invention may be 5% by mass or less, preferably 4% by mass or less, and more preferably 3% by mass or less, based on the total mass of the composition.

[0146] The amount of (f) the additional compound in the composition according to the present invention may be 0.001% to 5% by mass, preferably 0.01% to 4% by mass, and more preferably 0.05% to 3% by mass, relative to the total mass of the composition.

[0147] [Hyaluronic acid ingredient] The composition according to the present invention may contain at least one hyaluronic acid component selected from the group consisting of hyaluronic acid, hyaluronic acid salts, hyaluronic acid derivatives, hyaluronic acid derivative salts, and mixtures thereof. A single type of hyaluronic acid component may be used, or two or more different types of hyaluronic acid components may be used in combination.

[0148] Hyaluronic acid is the dominant glycosaminoglycan found in the skin. Therefore, fibroblasts predominantly synthesize collagen, other matrix glycoproteins (fibronectin, laminin), proteoglycans, and elastin. Keratin-producing cells predominantly synthesize sulfated glycosaminoglycans and hyaluronic acid. Hyaluronic acid is also known as hyaluronan.

[0149] Hyaluronic acid exists in a free state within the epidermis and dermis and influences the fullness of the skin. This polysaccharide can actually hold a large volume of water equivalent to up to 1000 times its own mass. In this sense, hyaluronic acid plays an important role in increasing the amount of water bound within tissues, as well as in the mechanical properties of the skin and wrinkle formation.

[0150] Hyaluronic acid can be represented by the following chemical formula:

[0151] [ka]

[0152] In the context of this invention, the term "hyaluronic acid" specifically includes the basic unit of hyaluronic acid as shown in the following formula.

[0153] [ka]

[0154] This is the smallest fraction of hyaluronic acid, containing disaccharide dimers, namely D-glucuronic acid and N-acetylglucosamine.

[0155] Hyaluronic acid derivatives can be selected from the group consisting of hydrolyzed hyaluronic acid, acetylated hyaluronic acid, cationic hyaluronic acid, and mixtures thereof.

[0156] Cationic hyaluronic acid contains at least one cationic moiety. The cationic moiety is -N + The cationic moiety may also consist of a trialkylammonium group such as (CH3)3. The cationic moiety may contain at least one hydroxyl group. An example of a cationic group is -CH2-CH(OH)-CH2-N + (CH3)3 is one example.

[0157] An example of a cationic hyaluronic acid is hydroxypropyltrimonium hyaluronate.

[0158] Examples of hyaluronic acid salts or hyaluronic acid derivative salts include alkali metal salts such as sodium salts and potassium salts, alkaline earth metal salts such as magnesium salts, ammonium salts, and mixtures thereof.

[0159] The molecular weight of the hyaluronic acid component is not limited. The molecular weight of the hyaluronic acid component may be 5 kDa or more, preferably 20 kDa or more, and more preferably 100 kDa or more. The molecular weight of the hyaluronic acid component may be 20 MDa or less, preferably 10 MDa or less, and more preferably 2,000 kDa or less. Therefore, the molecular weight of the hyaluronic acid component may be 5 kDa to 20 MDa, preferably 20 kDa to 10 MDa, and more preferably 100 kDa to 2,000 kDa.

[0160] Unless otherwise defined in the explanation, "molecular weight" can refer to the number-average molecular weight.

[0161] The hyaluronic acid component may be hyaluronic acid supplied by Hyactive under the trade name CPN (MW: 10-150kDa), by Soliance under the trade name Cristalhyal (MW: 1-1.4MDa), by Bioland under the names Nutra HA (MW: 820,000Da), by Bioland under the names Nutra AF (MW: 69,000Da), or by Bioland under the name Oligo HA (MW: 6100Da).

[0162] Either a single hyaluronic acid component with a single molecular weight may be used, or a combination of two or more hyaluronic acid components with different molecular weights may be used.

[0163] The amount of hyaluronic acid component in the composition according to the present invention may be 0.0001% by mass or more, preferably 0.0005% by mass or more, and more preferably 0.001% by mass or more, based on the total mass of the composition.

[0164] The amount of hyaluronic acid component in the composition according to the present invention may be 1% by mass or less, preferably 0.5% by mass or less, and more preferably 0.1% by mass or less, based on the total mass of the composition.

[0165] Therefore, the amount of hyaluronic acid component in the composition according to the present invention may be in the range of 0.0001% to 1% by mass, preferably 0.0005% to 0.5% by mass, and more preferably 0.001% to 0.1% by mass, relative to the total mass of the composition.

[0166] [Polyol] The composition according to the present invention may contain at least one polyol. If two or more polyols are used, they may be the same or different.

[0167] The term "polyol" here refers to an alcohol having two or more hydroxyl groups and does not include sugars or their derivatives. Derivatives of sugars include sugar alcohols obtained by reducing one or more carbonyl groups of a sugar, and sugars or sugar alcohols in which one or more hydrogen atoms in the hydroxyl groups are replaced by at least one substituent such as an alkyl group, hydroxyalkyl group, alkoxy group, acyl group, or carbonyl group.

[0168] The polyol used in this invention is at atmospheric pressure (760 mmHg or 10 5 It is a liquid at room temperature (such as 25°C) under Pa.

[0169] The polyol contains at least two hydroxyl groups, preferably two to five hydroxyl groups, C 2~24 Polyol, preferably C 2~9 Polyols are also acceptable.

[0170] The polyol may be a natural polyol or a synthetic polyol. The polyol may have a linear, branched, or cyclic molecular structure.

[0171] Polyols can be selected from glycerin and its derivatives, and glycols and their derivatives. Polyols include glycerin, diglycerin, polyglycerin, ethylene glycol, diethylene glycol, propylene glycol, dipropylene glycol, butylene glycol, pentylene glycol, hexylene glycol, and C6-C6. 24 The following can be selected: polyethylene glycol, 1,3-propanediol, 1,4-butanediol, and 1,5-pentanediol.

[0172] The amount of polyol in the composition used in the present invention may be 1% by mass or more, preferably 3% by mass or more, and more preferably 5% by mass or more, based on the total mass of the composition.

[0173] On the other hand, the amount of polyol in the composition used in the present invention may be 20% by mass or less, preferably 15% by mass or less, and more preferably 10% by mass or less, based on the total mass of the composition.

[0174] The amount of polyol in the composition used in the present invention may be within the range of 1% to 20% by mass, preferably 3% to 15% by mass, and more preferably 5% to 10% by mass, based on the total mass of the composition.

[0175] [Nonionic surfactants] The composition according to the present invention may contain at least one nonionic surfactant. If two or more surfactants are used, they may be the same or different.

[0176] Nonionic surfactants may have an HLB (hydrophilic-lipophilic balance) value of 8.0 to 14.0, preferably 9.0 to 13.5, and more preferably 10.0 to 13.0. When two or more nonionic surfactants are used, the HLB value is determined by the mass average of the HLB values ​​of all nonionic surfactants.

[0177] Nonionic surfactants can be selected from the following: (1) A surfactant selected from polyglyceryl fatty acid esters, polyoxyalkylene alkyl glycerides, and polyoxyalkylene fatty ethers. (2) Mixed esters of fatty acids or fatty alcohols, carboxylic acids and glycerols, (3) Fatty acid esters of sugars, and fatty alcohol ethers of sugars, (4) A surfactant selected from sorbitan fatty esters, sorbitan oxyalkylene fatty esters, and oxyalkylene fatty esters. (5) Block copolymer of ethylene oxide (A) and propylene oxide (B), (6) Polyoxyethylene (1-40EO) and polyoxypropylene (1-30PO) alkyl(C) 16 ~C 30 )ether, (7) Silicone surfactants, and (8) These mixtures.

[0178] The surfactant (1) may be a fluid at temperatures below 45°C.

[0179] The surfactant (1) may be any of the following: - At least one saturated or unsaturated linear or branched C8-C 22 Hydrocarbon groups, for example, C8~C 22 Alkyl or alkenyl group, preferably C8-C 18 Alkyl or alkenyl group, more preferably C8-C 12 Polyglyceryl fatty acid esters comprising at least one, preferably one, fatty acid containing an alkyl or alkenyl group, and 2 to 12 glycerol molecules, preferably 2 to 10 glycerol molecules, more preferably 2 to 8 glycerol molecules. - Polyoxyethylene-modified (PEGylated) alkyl glycerides, for example, polyethylene glycol derivatives of mixtures of mono-, di-, and tri-glycerides of caprylic and capric acid (preferably 2 to 30 ethylene oxide units, more preferably 2 to 20 ethylene oxide units, and even more preferably 2 to 10 ethylene oxide units), for example, PEG-6 (caprylic / capric acid) glyceride, PEG-7 (caprylic / capric acid) glyceride, and PEG-7 glyceryl coconut fatty acid. - At least one saturated or unsaturated linear or branched C8-C 22 Hydrocarbon groups, for example, C8~C 22 Alkyl or alkenyl group, preferably C8-C 18 Alkyl or alkenyl group, more preferably C8-C 12 Polyoxyethylene-derived fatty ethers comprising at least one, preferably one, fatty alcohol containing an alkyl or alkenyl group, and 2 to 60 ethylene oxides, preferably 2 to 30 ethylene oxides, more preferably 2 to 10 ethylene oxides, and - These mixtures.

[0180] The polyglyceryl fatty acid ester preferably has a polyglycerol moiety derived from 2 to 10 glycerols, more preferably 2 to 8 glycerols, and even more preferably 4 to 6 glycerols.

[0181] Polyglyceryl fatty acid esters can be selected from saturated or unsaturated acids, preferably saturated acids, such as mono, di, and triesters of caprylic acid, capric acid, lauric acid, oleic acid, stearic acid, isostearic acid, and myristic acid, which contain 8 to 22 carbon atoms, preferably 8 to 18 carbon atoms, and more preferably 8 to 12 carbon atoms.

[0182] Polyglyceryl fatty acid esters include PG2 caprate, PG2 dicaprate, PG2 tricaprate, PG2 caprylate, PG2 dicaprylate, PG2 tricaprylate, PG2 laurate, PG2 dilaurate, PG2 trilaurate, PG2 myristate, PG2 dimyristate, PG2 trimyristate, PG2 stearate, PG2 distearate, PG2 tristearate, PG2 isostearate, PG2 diisostearate, PG2 triisostearate, PG2 oleate, PG2 dioleate, PG2 trioleate, and PG2 caprate. 3. PG3 dicaprate, PG3 tricaprate, PG3 caprylate, PG3 dicaprylate, PG3 tricaprylate, PG3 laurate, PG3 dilaurate, PG3 trilaurate, PG3 myristate, PG3 dimyristate, PG3 trimyristate, PG3 stearate, PG3 distearate, PG3 tristearate, PG3 isostearate, PG3 diisostearate, PG3 triisostearate, PG3 oleate, PG3 dioleate, PG3 trioleate, PG4 caprate, PG4 dicaprate, PG4 tricaprate, PG4 PG4 PG4 dicaprylate, PG4 PG4 tricaprylate, PG4 PG4 laurate, PG4 dilaurate, PG4 trilaurate, PG4 myristate, PG4 dimyristate, PG4 trimyristate, PG4 stearate, PG4 distearate, PG4 tristearate, PG4 isostearate, PG4 diisostearate, PG4 triisostearate, PG4 oleate, PG4 dioleate, PG4 trioleate, PG5 caprate, PG5 dicaprate, PG5 tricaprate, PG5 caprylate, PG5 dicaprylate, tricapry PG5 acid, PG5 laurate, PG5 dilaurate, PG5 trilaurate, PG5 myristate, PG5 dimyristate, PG5 trimyristate, PG5 stearate, PG5 distearate, PG5 tristearate, PG5 isostearate, PG5 diisostearate, PG5 triisostearate, PG5 oleate, PG5 dioleate, PG5 trioleate, PG6 caprate, PG6 dicaprate, PG6 tricaprate, PG6 caprylate, PG6 dicaprylate, PG6 tricaprylate, PG6 laurate, PG6 dilaurate,PG6 Trilaurate, PG6 Myristate, PG6 Dimyristate, PG6 Trimyristate, PG6 Stearate, PG6 Distearate, PG6 Tristearate, PG6 Isostearate, PG6 Diisostearate, PG6 Triisostearate, PG6 Oleate, PG6 Dioleate, PG6 Trioleate, PG10 Caprate, PG10 Dicaprate, PG10 Tricaprate, PG10 Caprylate, PG10 Dicaprylate, Tricapry It can be selected from the group consisting of PG10 oyl acid, PG10 laurate, PG10 dilaurate, PG10 trilaurate, PG10 myristate, PG10 dimyristate, PG10 trimyristate, PG10 stearate, PG10 distearate, PG10 tristearate, PG10 isostearate, PG10 diisostearate, PG10 triisostearate, PG10 oleate, PG10 dioleate, and PG10 trioleate.

[0183] Polyoxyalkylene fatty acid ethers, preferably polyoxyethylene fatty acid ethers, may contain 2 to 60 ethylene oxide units, preferably 2 to 30 ethylene oxide units, and more preferably 2 to 10 ethylene oxide units. The fatty chain of the ether can be selected from lauryl, behenyl, arachidyl, stearyl, and cetyl units, as well as mixtures thereof, such as cetearyl. Examples of ethoxylated fatty acid ethers that can be listed are lauryl alcohol ethers containing 2, 3, 4, and 5 ethylene oxide units (CTFA names: laureth-2, laureth-3, laureth-4, and laureth-5), for example, products sold by Nikko Chemicals Co., Ltd. under the name Nikkol BL-2, by Nippon Emulsion Co., Ltd. under the name Emalex 703, by Nikko Chemicals Co., Ltd. under the name Nikkol BL-4, and by Nippon Emulsion Co., Ltd. under the name EMALEX 705.

[0184] (2) Mixed esters of fatty acids or fatty alcohols, carboxylic acids and glycerol can be used as the above-mentioned nonionic surfactants, and can be selected from the group including fatty acids or fatty alcohols having alkyl or alkenyl chains containing 8 to 22 carbon atoms, preferably 8 to 18 carbon atoms, more preferably 8 to 12 carbon atoms, and mixed esters of α-hydroxy acids and / or succinic acid and glycerol. The α-hydroxy acid may be, for example, citric acid, lactic acid, glycolic acid, or malic acid, or mixtures thereof.

[0185] The alkyl chains of fatty acids or alcohols from which the mixed esters used in the present invention are derived may be linear or branched, and may be saturated or unsaturated. These may include, in particular, stearate, isostearate, linoleate, oleate, behenate, arachidonate, palmitate, myristate, laurate, caprate, isostearyl, stearyl, linoleyl, oleyl, behenyl, myristyl, lauryl, or capryl chains, and mixtures thereof.

[0186] Examples of mixed esters that can be used in the present invention include a mixed ester of glycerol and a mixture of citric acid, lactic acid, linoleic acid, and oleic acid (CTFA name: glyceryl citric acid / lactic acid / linoleic acid / oleic acid), sold by Huls under the name Imwitor 375; a mixed ester of succinic acid and isostearyl alcohol and glycerol (CTFA name: isostearyl diglyceryl succinate), sold by Huls under the name Imwitor 780 K; a mixed ester of citric acid and stearic acid and glycerol (CTFA name: glyceryl citrate stearate), sold by Huls under the name Imwitor 370; and a mixed ester of lactic acid and stearic acid and glycerol (CTFA name: glyceryl lactate stearate), sold by Danisco under the names Lactodan B30 or Rylo LA30.

[0187] (3) Fatty acid esters of sugars that can be used as the above nonionic surfactants are, in particular, C8~C 22 Fatty acids and esters or ester mixtures of sucrose, maltose, glucose or fructose, and C 14 ~C 22 The group can be selected from those containing esters or ester mixtures of fatty acids and methyl glucose.

[0188] C8-C8, which form the fatty units of the esters that can be used in the present invention. 22 or C 14 ~C 22 Each fatty acid contains a saturated or unsaturated linear alkyl or alkenyl chain, each containing 8 to 22 or 14 to 22 carbon atoms. The fatty units of the ester can be selected from stearate, behenate, arachidonate, palmitate, myristate, laurate, and caprate, as well as mixtures thereof. Stearate is preferably used.

[0189] Examples of esters or ester mixtures of fatty acids with sucrose, maltose, glucose, or fructose include sucrose monostearate, sucrose distearate, and sucrose tristearate, as well as mixtures thereof, for example, products sold by Croda under the names Crodesta F50, F70, F110, and F160. An example of an ester or ester mixture of fatty acids with methyl glucose is polyglyceryl-3 methylglucose distearate, sold by Goldschmidt under the name Tego-care 450. Other examples of glucose or maltose monoesters include, for example, methyl o-hexadecanoyl-6-D-glucoside and o-hexadecanoyl-6-D-maltoside.

[0190] The (3) sugar fatty alcohol ethers that can be used as the above nonionic surfactant may be solid at temperatures below 45°C, and in particular C8~C 22Fatty alcohols and ethers or ether mixtures of glucose, maltose, sucrose, or fructose, and C 14 ~C 22 The group may be selected from those comprising ethers or ether mixtures of fatty alcohols and methyl glucose. These are, in particular, alkyl polyglucosides.

[0191] C8-C8, which form the fatty units of the ether that can be used in the present invention. 22 or C 14 ~C 22 Fatty alcohols each contain a saturated or unsaturated linear alkyl or alkenyl chain containing 8 to 22 or 14 to 22 carbon atoms. The fatty units of the ether can be selected from, in particular, decyl, cetyl, behenyl, arachidyl, stearyl, palmityl, myristyl, lauryl, capryl, and hexadecanoyl units, as well as mixtures thereof, such as cetearyl.

[0192] Examples of sugar fatty alcohol ethers include alkyl polyglucosides, such as decyl glucoside and lauryl glucoside, sold by Henkel under the names Plantaren 2000 and Plantaren 1200, respectively; cetostearyl glucoside, optionally as a mixture with cetostearyl alcohol, sold by SEPPIC under the name Montanov 68, by Goldschmidt under the name Tego-care CG90, and by Henkel under the name Emulgade KE3302; and arachidyl glucoside, for example, in the form of a mixture of arachidyl alcohol and behenyl alcohol with arachidyl glucoside, sold by SEPPIC under the name Montanov 202.

[0193] The surfactants used are, more specifically, sucrose monostearate, sucrose distearate, or sucrose tristearate, and mixtures thereof, polyglyceryl-3 methyl glucose distearate, and alkyl polyglucosides.

[0194] (4) Sorbitan fatty esters and oxyalkylenated sorbitan fatty esters that can be used as the above nonionic surfactant are the C 16 ~C 22 fatty acid esters of sorbitan, and oxyethylenated C 16 ~C 22 fatty acid esters of sorbitan can be selected from the group containing. These can be formed from at least one fatty acid containing at least one saturated straight-chain alkyl chain containing 16 to 22 carbon atoms each, and sorbitol or ethoxylated sorbitol. The oxyethylenated ester may generally contain 1 to 100 ethylene glycol units, preferably 2 to 40 ethylene oxide (EO) units.

[0195] These esters can be particularly selected from stearic acid esters, behenic acid esters, arachidic acid esters, palmitic acid esters, and mixtures thereof. Stearic acid esters and palmitic acid esters are preferably used.

[0196] Examples of the above nonionic surfactants that can be used in the present invention include sorbitan monostearate (CTFA name: sorbitan stearate) sold by ICI under the name Span 60, sorbitan monopalmitate (CTFA name: sorbitan palmitate) sold by ICI under the name Span 40, and sorbitan tristearate 20 EO (CTFA name: polysorbate 65) sold by ICI under the name Tween 65.

[0197] The (4) oxyalkylated fatty esters, preferably ethoxylated fatty esters, which can be used as the above nonionic surfactant, may be esters formed from 1 to 100 ethylene oxide units, preferably 2 to 60 ethylene oxide units, more preferably 2 to 30 ethylene oxide units, and at least one fatty acid chain containing 8 to 22 carbon atoms, preferably 8 to 18 carbon atoms, more preferably 8 to 12 carbon atoms. The fatty chains in the ester can be selected particularly from the units of stearate, behenate, arachidate and palmitate, and mixtures thereof. Examples of ethoxylated fatty esters that can be mentioned are esters of stearic acid containing 40 ethylene oxide units, such as the product sold by ICI under the name Myrj 52 (CTFA name: PEG-40 stearate), and esters of behenic acid containing 8 ethylene oxide units (CTFA name: PEG-8 behenate), such as the product sold by Gattefosse under the name Compritol HD5 ATO.

[0198] The (5) block copolymers of ethylene oxide (A) and propylene oxide (B) that can be used as the above nonionic surfactant are particularly those of the formula (I): HO(C2H4O) x (C3H6O) y (C2H4O) z H (I) [wherein x, y and z are integers such that x + z is in the range of 2 to 100 and y is in the range of 14 to 60], and mixtures thereof, and more particularly, can be selected from the block copolymers of the formula (I) having an HLB value in the range of 8.0 to 14.0.

[0199] The (6) polyoxyethylenated (1 to 16 40 EO) and polyoxypropylenated (1 to 30 30 PO) alkyl (C 16 ~C 30 ) ethers that can be used as the above nonionic surfactant are PPG-6 Decyltetradeceth-30; Polyoxyethylene (30) polyoxypropylene (6) tetradecyl ether, for example, those sold as Nikkol PEN-4630 manufactured by Nikko Chemicals Co., Ltd. PPG-6 Decyltetradeceth-12; Polyoxyethylene (12) polyoxypropylene (6) tetradecyl ether, for example, those sold as Nikkol PEN-4612 manufactured by Nikko Chemicals Co., Ltd. PPG-13 Decyltetradeceth-24; Polyoxyethylene (24) polyoxypropylene (13) decyltetradecyl ether, for example, those sold as UNILUBE 50MT-2200B manufactured by NOF Corporation. PPG-6 Decyltetradeceth-20; Polyoxyethylene (20) polyoxypropylene (6) decyltetradecyl ether, for example, those sold as Nikkol PEN-4620 manufactured by Nikko Chemicals Co., Ltd. PPG-4 Ceteth-1; Polyoxyethylene (1) polyoxypropylene (4) cetyl ether, for example, those sold as Nikkol PBC-31 manufactured by Nikko Chemicals Co., Ltd. PPG-8 Ceteth-1; Polyoxyethylene (1) polyoxypropylene (8) cetyl ether, for example, those sold as Nikkol PBC-41 manufactured by Nikko Chemicals Co., Ltd. PPG-4 Ceteth-10; Polyoxyethylene (10) polyoxypropylene (4) cetyl ether, for example, those sold as Nikkol PBC-33 manufactured by Nikko Chemicals Co., Ltd. PPG-4 Ceteth-20; Polyoxyethylene (20) polyoxypropylene (4) cetyl ether, for example, those sold as Nikkol PBC-34 manufactured by Nikko Chemicals Co., Ltd. PPG-5 Ceteth-20; Polyoxyethylene (20) polyoxypropylene (5) cetyl ether, for example, those sold as Procetyl AWS manufactured by Croda. PPG-8 ceteth-20; polyoxyethylene (20) polyoxypropylene (8) cetyl ether, such as that sold as Nikkol PBC-44 by Nikko Chemicals Co., Ltd., and PPG-23 steareth-34; polyoxyethylene polyoxypropylene stearyl ether (34 EO) (23 PO), such as that sold as Unisafe 34S-23 by Polar Kasei Kogyo Co., Ltd. can be selected from the group consisting of. These can provide long-term stability to the composition even when the temperature of the composition rises and falls in a relatively short period.

[0200] Polyoxyethylenated (1 - 40 EO) and polyoxypropylenated (1 - 30 PO) alkyl (C 16 ~C 30 ) ethers may more preferably be (15 - 40 EO) and polyoxypropylenated (5 - 30 PO) alkyl (C 16 ~C 24 ) ethers, which can be selected from the group consisting of PPG-6 decyltetradeceth-30, PPG-13 decyltetradeceth-24, PPG-6 decyltetradeceth-20, PPG-5 ceteth-20, PPG-8 ceteth-20, and PPG-23 steareth-34.

[0201] Polyoxyethylenated (1 - 40 EO) and polyoxypropylenated (1 - 30 PO) alkyl (C 16 ~C 30 ) ethers may even more preferably be (15 - 40 EO) and polyoxypropylenated (5 - 30 PO) alkyl (C 16 ~C 24 ) ethers, which can be selected from the group consisting of PPG-6 decyltetradeceth-30, PPG-13 decyltetradeceth-24, PPG-5 ceteth-20, and PPG-8 ceteth-20.

[0202] Examples of silicone surfactants that can be used as the above-mentioned nonionic surfactants include those disclosed in U.S. Patent No. 5,364,633(A) and U.S. Patent No. 5,411,744(A).

[0203] The above nonionic surfactant (7) silicone surfactant is preferably of formula (I):

[0204] [ka]

[0205] [In the formula, R1, R2, and R3 are independently C1-C6 alkyl groups, or -(CH2) x -(OCH2CH2) y -(OCH2CH2CH2) z - Represents an OR4 group, where at least one of R1, R2, or R3 is not an alkyl group, and R4 is hydrogen, an alkyl group, or an acyl group. A is an integer in the range of 0 to 200. B is an integer between 0 and 50, provided that A and B are not both equal to zero at the same time. x is an integer in the range of 1 to 6. y is an integer in the range of 1 to 30. z is an integer in the range of 0 to 5. It could be a compound of [the compound].

[0206] According to a preferred embodiment of the present invention, in the compound of formula (I), the alkyl group is a methyl group, x is an integer in the range of 2 to 6, and y is an integer in the range of 4 to 30.

[0207] As an example of a silicone surfactant of formula (I), formula (II):

[0208] [ka]

[0209] Examples of compounds can be given in the formula [wherein A is an integer in the range of 20 to 105, B is an integer in the range of 2 to 10, and y is an integer in the range of 10 to 20].

[0210] As an example of a silicone surfactant of formula (I), formula (III): H-(OCH2CH2) y -(CH2)3-[(CH3)2SiO] A' -(CH2)3-(OCH2CH2) y -OH (III) Compounds of the form [wherein A' and y are integers in the range of 10 to 20] can also be listed.

[0211] The compounds of the present invention that can be used are those sold by Dow Corning under the names DC 5329, DC 7439-146, DC 2-5695, and Q4-3667. Compounds DC 5329, DC 7439-146, and DC 2-5695 are compounds of formula (II) [wherein A is 22, B is 2, and y is 12, respectively; A is 103, B is 10, and y is 12; and A is 27, B is 3, and y is 12].

[0212] Compound Q4-3667 is a compound of formula (III) [wherein A is 15 and y is 13].

[0213] The amount of nonionic surfactant in the composition used in the present invention may be 0.01% by mass or more, preferably 0.05% by mass or more, and more preferably 0.1% by mass or more, based on the total mass of the composition.

[0214] On the other hand, the amount of nonionic surfactant in the composition used in the present invention may be 5% by mass or less, preferably 3% by mass or less, and more preferably 1% by mass or less, based on the total mass of the composition.

[0215] The amount of the nonionic surfactant in the composition used in the present invention may be in the range of 0.01% to 5% by mass, preferably 0.05% to 3% by mass, more preferably 0.1% to 1% by mass, based on the total mass of the composition.

[0216] [Other components] The composition according to the present invention may contain at least one monohydric alcohol that is in a liquid form at room temperature (25 °C), such as a linear or branched monohydric alcohol containing 1 to 6 carbon atoms, such as ethanol, propanol, butanol, isopropanol, isobutanol, pentanol, and hexanol.

[0217] The amount of the monohydric alcohol in the composition according to the present invention may be 0.01% by mass or more, preferably 0.1% by mass or more, more preferably 1% by mass or more, based on the total mass of the composition.

[0218] On the other hand, the amount of the monohydric alcohol in the composition according to the present invention may be 15% by mass or less, preferably 10% by mass or less, more preferably 5% by mass or less, based on the total mass of the composition.

[0219] Therefore, the amount of the monohydric alcohol in the composition according to the present invention may be in the range of 0.01% to 15% by mass, preferably 0.1% to 10% by mass, more preferably 1% to 5% by mass, based on the total mass of the composition.

[0220] The composition according to the present invention may contain at least one pH adjuster.

[0221] As the pH adjuster, at least one acidifying agent and / or at least one basifying agent (alkali agent) may be used.

[0222] The acidifying agent can be, for example, an inorganic acid or an organic acid, such as hydrochloric acid, phosphoric acid, sulfonic acid, and carboxylic acid, such as lactic acid.

[0223] The acidifying agent may be present in an amount of less than 5% by mass, preferably 3% by mass or less, and more preferably 1% by mass or less, relative to the total mass of the composition.

[0224] Basicizing agents, or alkaline agents, include, for example, any inorganic or organic basic agent commonly used in cosmetics, such as ammonia; alkanolamines, such as mono-, di-, and tri-ethanolamines, isopropanolamines; metal hydroxides, such as alkali metal hydroxides (e.g., sodium hydroxide and potassium hydroxide); urea, guanidine, and their derivatives; and diamines, such as those with the following structure:

[0225] [ka]

[0226] [In the formula, R may be an alkylene such as propylene, which is optionally substituted with a hydroxyl group or a C1-C4 alkyl group, and R1, R2, R3, and R4 independently represent a hydrogen atom, an alkyl group, or a C1-C4 hydroxyalkyl group, as exemplified by 1,3-propanediamine and its derivatives. Alkali metal hydroxides such as potassium hydroxide are preferred.

[0227] The pH of the composition according to the present invention may be less than 7, preferably 6 or less, and more preferably 5.5 or less. The pH of the composition according to the present invention may be 3.5 or higher, preferably 4.0 or higher, and more preferably 4.5 or higher. Therefore, the pH of the composition according to the present invention may be between 3.5 and less than 7, preferably between 4.0 and 6, and more preferably between 4.5 and 5.5.

[0228] The compositions according to the present invention may also contain, in addition to the components described above, various adjuvants conventionally used in cosmetic compositions, such as thickeners, anionic, nonionic, cationic, and amphoteric or zwitterionic polymers, anionic, cationic, and amphoteric surfactants, antioxidants, colorants, chelating agents, metal ion sequestering agents, fragrances, dispersants, conditioning agents, film-forming agents, preservatives, co-preservatives, and mixtures thereof.

[0229] [Preparation] The compositions of the present invention can be prepared by mixing the essential components described above and, if necessary, the optional components described above.

[0230] The methods and means for mixing the above-mentioned essential components and optional components are not limited. Any conventional methods and means can be used to mix the above-mentioned essential components and optional components to prepare the compositions according to the present invention.

[0231] [form] The composition according to the present invention is transparent.

[0232] Transparency can be measured by measuring turbidity (for example, turbidity can be measured using a 2100Q (commercially available from Hach Company) which has a round cell (25 mm in diameter and 60 mm in height) and a tungsten filament bulb capable of emitting visible light (between 400 and 800 nm, preferably 400 to 500 nm)). The measurement can be performed in an undiluted composition. A blank can be determined using distilled water.

[0233] The composition according to the present invention may have a turbidity of 50 NTU or less, preferably 40 NTU or less, more preferably 30 NTU or less, more preferably 20 NTU or less, more preferably 10 NTU or less, and even more preferably 5 NTU or less.

[0234] The form of the composition according to the present invention is not limited. Therefore, the composition according to the present invention may be in the form of a solution, gel, or emulsion.

[0235] However, it is preferable that the composition according to the present invention is not in the form of an emulsion.

[0236] Nevertheless, when the composition according to the present invention is in the form of an emulsion, the composition according to the present invention comprises a continuous phase and a dispersed phase. The dispersed phase is dispersed in the continuous phase. Therefore, the dispersed phase may be in the form of particles. The continuous phase may contain (d) water. The dispersed phase may contain oil, if present.

[0237] If the composition according to the present invention contains oil, it may be in the form of nano or microemulsions.

[0238] The term "microemulsion" can be defined in two ways, broadly and narrowly. One definition refers to a thermodynamically stable, isotropic single liquid phase containing a three-component system comprising an oily component, an aqueous component, and a surfactant ("microemulsion in the narrow sense"). The other definition refers to a typical thermodynamically unstable emulsion system that includes microemulsions that exhibit a transparent or translucent appearance due to their smaller particle size ("microemulsion in the broad sense"). (Satoshi Tomomasa et al., Oil Chemistry, Vol. 37, No. 11 (1988), pp. 48-53). As used herein, "microemulsion" refers to a "microemulsion in the narrow sense," that is, a thermodynamically stable, isotropic single liquid phase.

[0239] A microemulsion refers to one of the following states: an O / W (oil-in-water) type microemulsion in which oil is solubilized by micelles, a W / O (water-in-oil) type microemulsion in which water is solubilized by reverse micelles, or a bicontinuous microemulsion in which the number of surfactant molecules that can aggregate becomes infinite, resulting in both the aqueous and oil phases having a continuous structure.

[0240] The microemulsion may have a dispersed phase with a particle size of 100 nm or less, preferably 80 nm or less, and more preferably 60 nm or less, as measured by laser particle size analysis.

[0241] Here, "nanoemulsion" refers to an emulsion characterized by a dispersed phase having a size of less than 350 nm, which is stabilized by a surfactant crown that, if present, can optionally form a lamellar-type liquid crystal phase at the dispersed phase / continuous phase interface. In the absence of certain opacifiers, the transparency of the nanoemulsion arises from the small size of the dispersed phase, which is achieved by mechanical energy, particularly the use of a high-pressure homogenizer.

[0242] Nanoemulsions can be distinguished from microemulsions by their structure. Specifically, microemulsions are thermodynamically stable dispersions formed from micelles, if present, that are formed by surfactants and expanded with oil. Furthermore, microemulsions require virtually no mechanical energy to prepare.

[0243] The nanoemulsion may have a dispersed phase having a particle size of 300 nm or less, preferably 200 nm or less, and more preferably 100 nm or less, as measured by laser particle size analysis.

[0244] The composition according to the present invention may be in the form of an O / W type nanoemulsion or microemulsion, or in the form of a W / O type nanoemulsion or microemulsion. Preferably, the composition according to the present invention is in the form of an O / W type nanoemulsion or microemulsion.

[0245] Since the O / W type composition or structure consists of an oil phase dispersed in an aqueous phase, it has an aqueous phase on the outside, and therefore, when the composition according to the present invention has an O / W type composition or structure, it can provide a pleasant feeling of use due to the immediate freshness that the aqueous phase can provide.

[0246] The particle size of oil droplets, if present, may be 100 nm or less, preferably 75 nm or less, and more preferably 50 nm or less. The particle size can be measured by dynamic light scattering. Particle size measurement can be performed, for example, by the ELSZ-2000 series particle size analyzer, commercially available from Otsuka Electronics Co., Ltd.

[0247] The particle size may be the volume-average particle diameter or the number-average particle diameter, preferably the volume-average particle diameter.

[0248] [Method and Use] The composition according to the present invention is preferably a cosmetic composition, more preferably a skin cosmetic composition, and more preferably a skin peeling composition. Skin peeling, in this context, means peeling the superficial surface of the skin, particularly the stratum corneum.

[0249] The term "skin" here includes the skin of the face, the skin of the neck, and the scalp. The compositions according to the present invention can also be used on mucous membranes, such as the lips.

[0250] The compositions according to the present invention can be used for non-therapeutic methods such as cosmetic methods for treating keratinous substances, preferably for treating skin, and more preferably for peeling skin, by applying them to keratinous substances.

[0251] Accordingly, the present invention also relates to a cosmetic method for treating a keratinous substance, preferably for treating skin, and more preferably for peeling skin, the method comprising the step of applying a composition according to the present invention to a keratinous substance, particularly to skin.

[0252] The present invention may also relate to the use of the compositions according to the present invention as cosmetics, such as skin care products, or in cosmetics. In other words, the compositions according to the present invention can be used as cosmetics as they are. Alternatively, the compositions according to the present invention can be used as an element of cosmetics. For example, the compositions according to the present invention can be added to or combined with any other elements to form cosmetics.

[0253] Care products may be in the form of solutions, gels, lotions, etc.

[0254] Since the composition according to the present invention contains at least one first compound selected from polyhydroxy acids and their salts, the composition according to the present invention can be used for skin peeling while reducing the resulting stickiness and reducing skin discomfort such as reduced skin irritation.

[0255] Another aspect of the present invention relates to reducing skin discomfort such as stickiness and skin irritation caused by the composition when applied to the skin. (a) at least one first compound selected from polyhydroxy acids and their salts, and (d) water In a composition containing, (b) at least one second compound selected from vitamin B3 and its derivatives, (c) The following chemical formula (I): Z-{O(AO) l (EO) m -(BO) n H} a (I) [In the formula, Z represents a residue obtained by removing hydroxyl groups from a compound having 3 to 9 hydroxyl groups. AO represents an oxyalkylene group having 3 to 4 carbon atoms. EO indicates an oxyethylene group. BO represents an oxyalkylene group having four carbon atoms. 'a' represents 3-9, l, m, and n represent the average number of moles added of AO, EO, and BO, respectively, with 1 ≤ l ≤ 50, 1 ≤ m ≤ 50, and 0.5 ≤ n ≤ 5. The mass ratio of AO to EO (AO / EO) is in the range of 1 / 5 to 5 / 1. AO and EO may be added randomly or in block form. Represented by, at least one alkylene oxide derivative and The use of a combination of, (a) The amount of the first compound in the composition is 1% by mass or more, preferably 3% by mass or more, and more preferably 5% by mass or more, based on the total mass of the composition. Regarding use.

[0256] The above descriptions of components (a) to (d) and optional components for the compositions according to the present invention can be applied to the components for the above-described uses of the present invention. The descriptions of the preparation and form of the compositions according to the present invention can also be applied to the descriptions of the compositions described for the above-described uses of the present invention. [Examples]

[0257] The present invention will be described in more detail by reference to examples, but this should not be construed as limiting the scope of the invention.

[0258] (Example 1 and Comparative Examples 1-3) The compositions shown in Table 1, according to Example 1 and Comparative Examples 1-3, were prepared by mixing the components shown in Table 1. All numerical values ​​for the amounts of components shown in Table 1 are based on the "mass%" of the raw materials.

[0259] [Table 1]

[0260] [evaluation] (transparency) The transparency of the compositions in Example 1 and Comparative Examples 1-3 was also determined by visual observation according to the following criteria. Excellent: Transparent Good: Slightly translucent Defective: Translucent Very poor: Opaque

[0261] The results are shown in Table 1.

[0262] (Non-sticky) The stickiness of the compositions from Example 1 and Comparative Examples 1-3 was measured using a texture analyzer (TA. XT plus by Eikoh Seiki Co., Ltd.).

[0263] Compositions from Example 1 and Comparative Examples 1-3, each 10 mg in size, were applied to BioSkin (square shape: 2cm x 2cm) available from Beaulax. The metal head probe of a texture analyzer on the BioSkin was moved downward with a predetermined force to bring it into contact with the BioSkin. The metal head was then lifted while measuring negative force data. The negative force data indicates how much force is required to lift the metal head probe and is related to stickiness. The peak of the negative force data was recorded. The smaller the negative force data, the greater the stickiness. This was repeated 100 times for each composition, and the peak negative force values ​​were averaged. For the compositions from Example 1 and Comparative Examples 1-3, the absolute value of the average peak negative force was classified according to the following criteria. Excellent: ≤100 Good: 100 < and ≤ 110 Defective: 110 < and ≤ 120 Very poor: 120

[0264] The results are shown in Table 1.

[0265] (skin irritation) In vitro evaluation was performed using EpiSkin™.

[0266] EpiSkin® tissues (20ER34, 20ER35) and maintenance media were obtained from Shanghai EPISKIN Biotechnology Co., Ltd., along with the necessary QC reports. Upon receipt, these were subjected to regeneration in an incubator at 37°C and 5% CO2 for at least 24 hours before conducting the experiment.

[0267] Preliminary tests for MTT interactions were performed on all compositions from Example 1 and Comparative Examples 1-3. Each composition was incubated with a 3.3 mg / mL MTT solution at 37°C for at least 15 minutes, and any color changes were recorded for further testing.

[0268] For cytokine analysis, in one experiment for each individual concentration, topical application of 35 μL of each composition was performed over a 48-hour treatment period in two replicate skin tissues. At the end of the treatment, the media at the bottom was collected and sent for analysis using a Luminex system. EpiSkin® tissue was collected for viability determination. Final data were corrected for viability determination, and the mean level for each cytokine was expressed as pg / mL. For ranking analysis, at least a 2x change was considered.

[0269] The grades were classified according to the following two criteria based on cytokine levels. Good: IL-8 < 2 and IL-1α < 2.8 Poor: IL-8 > 2 or IL-1α > 2.8 "Good" means there is no risk of skin irritation. "Poor quality" means there is a risk of skin irritation.

[0270] The results are shown in Table 1.

[0271] (Examples 2 and Comparative Examples 4-6) The compositions shown in Table 2, according to Example 2 and Comparative Examples 4-6, were prepared by mixing the components shown in Table 2. All numerical values ​​for the components shown in Table 2 are based on the "mass%" of the raw materials.

[0272] [Table 2]

[0273] [evaluation] (transparency) The transparency of the compositions in Example 2 and Comparative Examples 4-6 was also determined by visual observation according to the following criteria. Excellent: Transparent Good: Slightly translucent Defective: Translucent Very poor: Opaque

[0274] The results are shown in Table 2.

[0275] (Non-sticky) The stickiness of the compositions from Example 2 and Comparative Examples 4-6 was measured using a texture analyzer (TA. XT plus by Eikoh Seiki Co., Ltd.).

[0276] Compositions from Example 2 and Comparative Examples 4-6, each 10 mg in size, were applied to BioSkin (square shape: 2cm x 2cm) available from Beaulax. The metal head probe of a texture analyzer on the BioSkin was moved downward with a predetermined force to bring it into contact with the BioSkin. The metal head was then lifted while measuring negative force data. The negative force data indicates how much force is required to lift the metal head probe and is related to stickiness. The peak of the negative force data was recorded. A smaller negative force data indicates greater stickiness. This was repeated 100 times for each composition, and the peak negative force values ​​were averaged. The absolute values ​​of the average peak negative force for the compositions from Example 2 and Comparative Examples 4-6 were classified according to the following criteria. Excellent: ≤100 Good: 100 < and ≤ 110 Defective: 110 < and ≤ 120 Very poor: 120

[0277] The results are shown in Table 2.

[0278] (skin irritation) In vitro evaluation was performed using EpiSkin™.

[0279] EpiSkin® tissues (20ER34, 20ER35) and maintenance media were obtained from Shanghai EPISKIN Biotechnology Co., Ltd., along with the necessary QC reports. Upon receipt, these were subjected to regeneration in an incubator at 37°C and 5% CO2 for at least 24 hours before conducting the experiment.

[0280] Preliminary tests for MTT interactions were performed on all compositions from Example 2 and Comparative Examples 4-6. Each composition was incubated with a 3.3 mg / mL MTT solution at 37°C for at least 15 minutes, and any color changes were recorded for further testing.

[0281] For cytokine analysis, in one experiment for each individual concentration, topical application of 35 μL of each composition was performed over a 48-hour treatment period in two replicate skin tissues. At the end of the treatment, the media at the bottom was collected and sent for analysis using a Luminex system. EpiSkin® tissue was collected for viability determination. Final data were corrected for viability determination, and the mean level for each cytokine was expressed as pg / mL. For ranking analysis, at least a 2x change was considered.

[0282] The grades were classified according to the following two criteria based on cytokine levels. Good: IL-8 < 2 and IL-1α < 2.8 Poor: IL-8 > 2 or IL-1α > 2.8 "Good" means there is no risk of skin irritation. "Poor quality" means there is a risk of skin irritation.

[0283] The results are shown in Table 2.

Claims

1. (a) Gluconolactone, (b) at least one compound selected from vitamin B3 and its derivatives, (c) The following chemical formula (I): Z-{O(AO) l (E.O.) m -(BO) n H} a (I) [In the formula, Z represents a residue obtained by removing hydroxyl groups from a compound having 3 to 9 hydroxyl groups. AO represents an oxyalkylene group having 3 to 4 carbon atoms. EO indicates an oxyethylene group. BO represents an oxyalkylene group having four carbon atoms. 'a' represents 3 to 9. l, m, and n represent the average number of moles added of AO, EO, and BO, respectively, with 1 ≤ l ≤ 50, 1 ≤ m ≤ 50, and 0.5 ≤ n ≤ 5. The mass ratio of AO to EO (AO / EO) is in the range of 1 / 5 to 5 / 1. AO and EO may be added randomly or in block form. At least one alkylene oxide derivative represented by, and (d) water A transparent composition comprising, A composition in which the amount of (a) gluconolactone in the composition is 1% by mass or more relative to the total mass of the composition.

2. The composition according to claim 1, wherein the amount of (a) gluconolactone in the composition is 1% by mass to 20% by mass of the total mass of the composition.

3. (b) The composition according to claim 1 or 2, wherein the compound is niacinamide.

4. The composition according to any one of claims 1 to 3, wherein the amount of compound (b) in the composition is 1% by mass to 20% by mass relative to the total mass of the composition.

5. (c) The alkylene oxide derivative has the following chemical formula (II): Gly-{O(PO) s (E.O.) t -(BO) u H} 3 (II) [In the formula, Gly refers to the residue obtained by removing the hydroxyl group from glycerol. PO indicates an oxypropylene group. EO indicates an oxyethylene group. s and t represent the average number of moles added to PO and EO, respectively, and have values ​​within the range of 1 to 50. The mass ratio of PO to EO (PO / EO) is in the range of 1 / 5 to 5 / 1. BO represents an oxyalkylene group having four carbon atoms. u represents the average number of moles added to BO, and is in the range of 0.5 to 5. The composition according to any one of claims 1 to 4, as represented by [the specified method].

6. (c) The composition according to any one of claims 1 to 5, wherein the alkylene oxide derivative is PEG / PPG / polybutylene glycol-8 / 5 / 3.

7. The composition according to any one of claims 1 to 6, wherein the amount of (c) alkylene oxide derivative in the composition is 0.1% by mass to 12% by mass with respect to the total mass of the composition.

8. (e) The composition according to any one of claims 1 to 7, further comprising at least one oil in an amount of 1% by mass or less based on the total mass of the composition.

9. The composition according to any one of claims 1 to 8, further comprising (a) a compound different from gluconolactone, (f) at least one additional compound selected from alpha-hydroxy acids, beta-hydroxy acids, phytic acid, and mixtures thereof.

10. The composition according to claim 9, wherein the amount of (f) the additional compound in the composition is 0.001% by mass to 5% by mass, relative to the total mass of the composition.

11. A cosmetic composition according to any one of claims 1 to 10.

12. A cosmetic method for treating a keratin substance, comprising the step of applying a composition according to any one of claims 1 to 11 to the keratin substance.

13. To reduce the stickiness and skin discomfort caused by the composition when applied to the skin, (a) gluconolactone, and (d) water In a composition containing, (b) at least one compound selected from vitamin B3 and its derivatives, (c) The following chemical formula (I): Z-{O(AO) l (E.O.) m -(BO) n H} a (I) [In the formula, Z represents a residue obtained by removing hydroxyl groups from a compound having 3 to 9 hydroxyl groups. AO represents an oxyalkylene group having 3 to 4 carbon atoms. EO indicates an oxyethylene group. BO represents an oxyalkylene group having four carbon atoms. 'a' represents 3 to 9. l, m, and n represent the average number of moles added of AO, EO, and BO, respectively, with 1 ≤ l ≤ 50, 1 ≤ m ≤ 50, and 0.5 ≤ n ≤ 5. The mass ratio of AO to EO (AO / EO) is in the range of 1 / 5 to 5 / 1. AO and EO may be added randomly or in block form. Represented by, at least one alkylene oxide derivative and The use of a combination of, The amount of (a) gluconolactone in the composition is 1% by mass or more relative to the total mass of the composition. use.

Images