Saccharomyces cerevisiae extract for exosome content modulation
Patent Information
- Authority / Receiving Office
- NL · NL
- Patent Type
- Patents
- Current Assignee / Owner
- COTY INC
- Filing Date
- 2025-07-29
- Publication Date
- 2026-06-22
AI Technical Summary
Existing dermatological treatments focus on ameliorating the cosmetic consequences of skin aging and senescence rather than preventing the underlying morbidity associated with aging and senescent skin, particularly through the modulation of extracellular matrix components and metalloproteinase activity.
An extract of Saccharomyces cerevisiae, specifically the cytosolic fraction comprising oligo-β-glucans with a molar mass of 2 to 5 kDa, is used to modulate exosome content, reducing specific miRNA expression and increasing gene expression of collagen I, collagen III, and decorin, while decreasing MMP3 and MMP12 expression, thereby maintaining extracellular matrix homeostasis and preventing skin aging and senescence.
The extract effectively prevents signs of intrinsic and extrinsic skin aging by enhancing collagen and decorin production and inhibiting elastin degradation, leading to improved skin firmness, elasticity, and reduced wrinkle formation.