3-(4-(4-arylpiperazin-1-yl) butyl-4H-chromen-4-one, process of preparation and its therapeutic application

Abstract

The present invention relates a compound of general formula 1: wherein: R1 represents one or more identical or different substituent(s) on the benzene ring, each representing, independently, a hydrogen atom or a halogen atom, or a C1-4alkoxy group or an OH group, or a C1-4alkyl group or an -0(CH2)n0- group in which n = 1 or 2. -R2 represents a hydrogen atom or a C1-4alkyl group. -A and B represent, independently, either a nitrogen atom or a carbon atom. R3 represents a hydrogen atom or one or more identical or different substituent(s) selected from the group composed of : a halogen atom, a C1-4alkyl group, a C1-4alkoxy or C1-4thioalkoxy group, an -0(CH2)n0- group in which n = 1 or 2, an NO2 group, an NHSO2R4 group, an NHR5 group, an OH group, a C1-4haloalkyl group, a CN group, a C1-4alkoxycarbonyl group, a C1-4alkylcarbonyl group, a C1-4hydroxyalkyl group and a benzyl or phenyl substituent optionally substituted by a C1-4alkoxy or a C1-4alkyl group or a halogen atom, their pharmaceutical composition and their application as D3 dopaminergic ligands as a medicament for disorders of the central nervous system.