Immunogenic composition having an antigen, lipopolysaccharide and quillaja saponaria moiina saponin fraction in the form of a liposome

Abstract

The present invention provides an immunogenic composition comprising an antigen or antigenic preparation, in coin- binstion with an adjuvant which adjuvant comprises an immunologically active saponin fraction derived from the bark of Quillaja Saponaria Molina presented in the form of liposome and a lipopolysaccharide wherein said saponin fraction and said lipopolysaccharide are both present in said human dose at a level of below 30 lig. The present invention further provides an adjuvant composition in a human dose suitable volume comprising between 1 and 30 mg of a lipopolysaccharide and between 1 and 30 lig of an immunologically active saponin fraction presented in the form of a liposome.