Method for treating purulent inflammation of base of skin of cattle hooves

Abstract

FIELD: veterinary medicine.SUBSTANCE: used in the treatment of purulent inflammation of the base of the skin of the cattle hooves. Orthopedic trimming of the hooves is performed, devitalized tissue is removed, and an orthopedic block is glued to the healthy toe of the animal on the same limb. An even layer of Vet-Kopem ointment is applied to the affected area. The ointment consists of the following components, wt.%: egotsin 20 – 47.6; “АСД-3ф” – 18.9; vitamin preparation Trivit – 14.7; iodinol – 8.2; dioxidine – 4.2; petroleum jelly – 6. Next, the area is covered with a gauze napkin, after which bandage is applied with a veterinary self-fixing elastic bandage. The procedure is repeated after 3-4 days in the first week, and once a week in the following days until local damage to the skin base in the hooves of cattle is completely healed.EFFECT: provision of an increase in the therapeutic effectiveness of the treatment of purulent inflammation of the base of the skin of the hooves of cattle and an enhancement of the antibacterial, antiseptic, and anti-inflammatory effect, resulting in a reduction in the healing time and restoration of the productive performance of animals.1 cl, 2 dwg, 1 tbl

Description

[0001] The invention relates to the field of veterinary medicine, in particular to veterinary surgery, including veterinary orthopedics, and can be used in the treatment of purulent inflammation of the base of the skin of the hooves of cattle.

[0002] Purulent inflammation of the base of the skin of the hooves - this purulent pododermatitis occurs in any part of the hoof, but most often in the sole area [1].

[0003] A known method for treating purulent-necrotic diseases and injuries of the hooves of cattle and small ruminants, and hooves of horses, is with Dorogova's balm No. 10, which contains the following active ingredients in 100 g: ASD-2F, respectively - 2.0 g, 3.0 g, 5.0 g; and ASD-3F, respectively - 2.0 g, 3.0 g, 5.0 g; as well as auxiliary components: propylparaben, methylparaben, sodium carbomer, castor oil, olive oil, hydroalcoholic extract of calendula, chamomile, glycerin and distilled water. Dorogova's balm No. 10 is used according to the known method once a day until recovery [2].

[0004] However, this method has its drawbacks. Topical application of Dorogova's Balsam can cause allergic reactions (rash, itching, and skin redness) due to hypersensitivity to the drug. Furthermore, Dorogova's Balsam lacks antibacterial properties, necessitating subsequent use of other medications. This prolongs the healing time of purulent-necrotic processes in the distal extremities of cows.

[0005] A method is known for treating purulent-necrotic processes in the area of ​​the toe in cows with the hoof ointment "Ungula Vita+)": ulcers of the interdigital arch, superficial and deep pododermatitis, phlegmon in the area of ​​the coronary band and cushion, open wounds of cattle and small ruminants.

[0006] Pharmacological properties: has a mild irritant effect, improves tissue blood supply, enhances epidermal regeneration, stimulates keratinization, has a keratoplastic effect, anti-inflammatory, wound healing, antiseptic (disinfectant), insecticidal, antiparasitic and antimicrobial agent of a broad spectrum of action.

[0007] Ungula Vita+ hoof ointment is applied externally following thorough surgical debridement of the wound, as is well known. For cattle, 25 grams of ointment is soaked into gauze and then applied to the wound. Dressings are changed every 2-3 days until the wound is completely healed [3].

[0008] The disadvantage of the hoof ointment "Ungula Vita+)" is the low therapeutic effect and the insignificant duration of the drug's action.

[0009] The purpose of the invention is to increase the therapeutic effectiveness of the treatment of purulent inflammation of the base of the skin of the hooves of cattle and to enhance the antibacterial, antiseptic, anti-inflammatory effect, resulting in a reduction in the healing time and restoration of the productive performance of animals.

[0010] The stated goal is achieved by the fact that in the treatment of purulent inflammation of the base of the skin in the area of ​​the hooves of cattle, an ointment is used, obtained by mixing known components, called "Vet-Kopem", consisting of the following components, by weight, %: egotsin 20 - 47.6; ASD-3f - 18.9; vitamin preparation Trivit - 14.7; iodinol - 8.2; dioxidine - 4.2; petroleum jelly - 6.4.

[0011] The method includes orthopedic hoof trimming, surgical treatment, and topical application of a medicinal product. We use Vet-Kopem ointment, which contains well-known pharmaceutical ingredients used in everyday medical practice. Each 600 grams contains: 290 g of egotsin, 115 g of ASD-3f, 90 g of Trivit (an oil solution of vitamins A, D3, and E), 50 g of iodinol, 25 g of dioxidine, and 30 g of petroleum jelly.

[0012] Egocin 20 - An antibacterial drug of the tetracycline group - oxytetracycline hydrochloride, which is part of the drug, has a broad spectrum of bacteriostatic action. It is active against gram-positive and gram-negative bacteria, including some species of Mycoplasma spp., Rickettsia spp., Chlamydia spp., Spirochaetaceae, Actinomyces spp.

[0013] ASD-3f - the biologically active substances included in the preparation have an antiseptic and anti-inflammatory effect, stimulate the activity of the reticuloendothelial system, normalize trophism and accelerate the regeneration of damaged tissues.

[0014] Vitamin preparation Trivit (oil solution of vitamins A, D3, E) - belongs to the group of vitamin preparations, has an effect on the normalization of metabolism.

[0015] Iodinol - has a bactericidal effect on both gram-positive and gram-negative flora (most active on streptococcal flora and E. coli), as well as on pathogenic fungi and yeast.

[0016] Dioxidine - A broad-spectrum chemotherapeutic drug from the group of quinoxaline derivatives, it is active against infections caused by Proteus vulgaris, dysentery bacillus, Klebsiella, Pseudomonas aeruginosa, Salmonella, Staphylococcus aureus, Streptococcus aeruginosa, pathogenic anaerobes (including gas gangrene pathogens), and acts on bacterial strains resistant to other chemotherapy drugs, including antibiotics.

[0017] The method is implemented as follows.

[0018] The method includes orthopedic trimming of hooves, surgical treatment: local curettage in order to remove devitalized tissue, gluing an orthopedic block on a healthy finger of the animal of the same limb to reduce the load on the pathological focus, and local application of a medicinal product in the form of applications, wherein the ointment "Vet-Kopem" is used as a medicinal product, consisting by weight, %: egotsin 20 - 47.6; ASD-3f - 18.9; vitamin preparation Trivit - 14.7; iodinol - 8.2; dioxidine - 4.2; Vaseline - 6.4, while the ointment is applied in an even layer to the affected area, covered with a gauze napkin, after which a bandage is made with a veterinary self-fixing elastic bandage, and the procedure is repeated after 3-4 days in the first week, and in the following days once a week until complete treatment of purulent inflammation of the base of the skin of the hooves of cattle.

[0019] Figure 1 shows the dynamics of healing in case of purulent inflammation of the base of the skin of the hooves of cattle on different days of treatment, control group, left thoracic limb, cow No. 3831, ointment "Ungula Vita+)",

[0020] Figure 2 shows the dynamics of healing in case of purulent inflammation of the base of the skin of the hooves of cattle on different days of treatment, 1 experimental group, left thoracic limb, cow No. 21144, Vet-Kopem ointment.

[0021] To determine the effectiveness of treatment with Vet-Kopem ointment, experimental clinical trials of the claimed method were conducted.

[0022] During the clinical trial of Vet-Kopem ointment, planimetric healing indices were measured in the hoof area throughout the treatment period. A sterile cellophane plate was placed in the hoof area and the contours of the wound were drawn on it. The wound area was measured using the ImageMeter application [4].

[0023] The measurements were carried out on the 1st, 3rd, 7th, 10th, 14th, 21st day - depending on the study being conducted, the percentage reduction in the area of ​​the purulent-necrotic surface in the hoof area per day was calculated in relation to the previous result using the formula [5]:

[0024] Δ ;

[0025] where: S is the size of the wound area during the previous measurement;

[0026] S n - the size of the wound area during a given measurement;

[0027] t - number of days between measurements.

[0028] The results of experimental and clinical trials of the claimed method showed that a single application of Vet-Kopem ointment led to a reduction in the area of ​​​​the pathology, a decrease in pain, with three times the application (on the 1st, 3rd, 7th, 10th, 14th day) - clinical signs of inflammation disappeared, the bottom of the pathology was replenished with healthy granulation tissue, with subsequent epithelialization and scarring of the surrounding tissues throughout the entire study period.

[0029] Before the treatment of purulent-necrotic lesions on the plantar surface of the hoof, the area of ​​damage in animals of the control group was 8.90±0.880 cm 2 , and in the experimental one - 11.01±2.805 cm 2 By the third day, the area of ​​the affected surface of the hooves, compared to the initial area, decreased in the control group of animals to 70.62%, in cows of the experimental group to 41.36%, and the area of ​​damage was 6.28±0.675, with P<0.05, and 4.55±0.880 cm 2, at P<0.05, respectively. Significant changes towards healing of purulent pododermatitis to the initial lesion area occurred on the 3rd and 7th days in all groups: in cows of the control group, the damaged areas decreased to 70.62% and 47.98%, and in the experimental group to 41.36% and 15.82%. The area of ​​damage significantly decreased throughout the entire period of healing of purulent necrotic lesions (Table 1). The healing rate index was not the same in the groups, the upper limit was observed in the control group on the 24th day and was equal to 99.66%, in the experimental group on the 14th day - 97.79% (Table 1). The highest dynamics of reduction in the area of ​​pathologies was observed in the experimental group and amounted to 58.64%, and the lowest - in the control group 29.37%. Then the healing rate gradually decreased and the minimum values ​​were noted in the control group on the 24th day - 5.06%, in the experimental group on the 14th day - 3.40% (Table 1)

[0030] High daily rates of reduction in the area of ​​necrotic lesions were recorded in cows in the control group - on the 24th day and amounted to 23.44%, in animals of the experimental group this value on the 10th day was 16.14%, accordingly, the minimum values ​​​​in control animals were noted on the 14th day - 5.84%, in cows of the experimental groups - on the 3rd day and amounted to 14.66% (Table 1).

[0031] Table 1.

[0032] Dynamics of the area of ​​local damage to the base of the hoof skin in cows with orthopedic diseases during treatment ( - X±S_ - X; n=10).

[0033] 24 hours of research Control group "Ungula Vita+) Vet-Kopem experimental group S, cm2 Yt,% IV ΔS,% S, cm2 Yt IV ΔS 0 days 8,90±0,880 11,01±2,805 Day 3 6,28±0,675 * 29,37 29,37 7,34 4,55±0,880 * 58,64 58,64 14,66 Day 7 4,27±0,542 *** 52,01 22,635 8,01 1,74±0,353 ** 84,17 25,53 15,43 10th day 2,88±0,527 *** 67,558 15,547 8,09 0,62±0,229 ** 94,39 10,22 16,14 14 ducks 2,21±0,552 *** 75,140 7,583 5,84 0,24±0,161 ** 97,79 3,40 15,15 21 days 0,48±0,229 *** 94,59 7,25 14,33 24 days 0,03±0,020 *** 99,66 5,06 23,44 Note: * (P<0.05); ** (P<0.01); *** (P<0.001) relative to the original data

[0034] Thus, the recovery of animals with purulent lesions of the base of the skin of the hooves of the plantar part of the limbs of cows in the control group was 22.5 ± 1.40 days, in animals of the experimental group - 13.0 ± 0.89 days, with P < 0.001. The use of experimental drugs made it possible to reduce the treatment time in the first experimental group by 10.1 days compared to the control group.

[0035] Source of information

[0036] 1. Kuznetsov A.K., Semenov B.S., Vysotsky D.I. Veterinary surgery, orthopedics and ophthalmology / / M.: Agropromizdat. - 1986. - T. 431. P - 372

[0037] 2. Balm Dorogovoy recipe No. 10, tube 100 ml / Electronic link: https: / / www.vetlek.ru / shop / ?gid=2377&id=10197.

[0038] 3. Hoof ointment "Ungula Vita+)" 450 gr. / Electronic link: https: / / timofeev21.ru / products / hoof-health / ungula-vita-p lus.

[0039] 4. ImageMeter Pro measurement app: sizes, angles, and areas. https: / / vk.com / @mister_gadget-prilozhenie-imagemeter-pro-android-izmerenie-razmery-ugly-i.

[0040] 5. Maryin, E.M. Surgical diseases in the toe area of ​​cows and their complex treatment with sorption-antiseptic drugs (clinical and experimental study): dis. Doctor of Veterinary Sciences: 06.02.04 / E.M. Maryin. - FGBOU VO "St. Petersburg State University of Veterinary Medicine", St. Petersburg, 2020. - 486 p.

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