Gossypol-containing stem borer-killing composition

Abstract

The present invention relates to the technical field of pest control in rice, and provides a chlorantraniliprole-containing composition, comprising chlorantraniliprole and gossypol, wherein the mass ratio of chlorantraniliprole to gossypol is (1000-50):1. The composition can be used for controlling lepidoptera pests which attack rice. The composition of the present invention has a good control effect on rice stem borers, can reduce the application dosage of chlorantraniliprole and reduce the control costs, and is suitable for use in practical production.

Description

A moth-killing composition containing gossypol Technical Field

[0001] The invention belongs to the technical field of rice disease and insect pest control, and relates to a medicament for controlling rice lepidopteran pests. Background Art

[0002] Gossypol, also known as cottonseed alcohol or cottonseed toxin, is a polyphenolic hydroxybinaphthaldehyde compound formed and stored in the pigment glands of cotton plants in the Malvaceae family. It is a yellow polyphenol found in various organs of cotton plants. Gossypol significantly affects the survival, reproduction, and populations of insect pests. Feeding cotton bollworm larvae with high levels of gossypol negatively impacts key vital parameters such as body weight, developmental stage, survival rate, pupation rate, emergence rate, mating rate, egg production, and hatching rate, resulting in insect resistance.

[0003] Chlorantraniliprole is a broad-spectrum insecticide with a novel structure selected from the diamide class of compounds. Its mechanism of action is to activate nicotinic acid receptors in the insect's muscles, leading to an excessive release of calcium ions. This inactivates the insect's feeding, causing muscle paralysis, loss of vitality, paralysis, and ultimately death. Since entering the Chinese pesticide market in 2010, chlorantraniliprole has been widely used to control a variety of agricultural and forestry pests. It is highly effective against Lepidoptera species such as Noctuidae, Pyralidae, Fruitborers, Leafrollers, Pulpworms, Diamondbacks, Lycopodidae, and Lepidoptera. It also controls a variety of non-Lepidoptera pests, including Coleoptera and Chrysomelidae, and Diptera such as Muscicapidae and Aleyrodidae. Currently registered for control of major rice pests, it can rapidly protect rice growth and is particularly effective against pests resistant to other rice insecticides, such as the rice leaf roller, the striped stem borer, the yellow stem borer, and the rice stem borer. It also has excellent control effects on the rice gall midge, the rice weevil, and the rice water weevil. Due to the long-term use of chlorantraniliprole, rice lepidopteran pests in many fields have developed varying levels of resistance, rendering the pesticide ineffective. Therefore, there is a need to find effective methods to delay the development of resistance. Summary of the Invention

[0004] In response to the current widespread and serious problem of chlorantraniliprole resistance in rice lepidoptera, the present invention provides a chlorantraniliprole-containing agent for controlling rice lepidoptera pests, which contains gossypol and can effectively improve the control effect and reduce the usage of chlorantraniliprole.

[0005] To achieve the above objectives, the present invention adopts the following technical solutions.

[0006] A chlorantraniliprole-containing composition comprises chlorantraniliprole and gossypol, wherein the mass ratio of chlorantraniliprole to gossypol is (1000-50):1; preferably, the mass ratio of chlorantraniliprole to gossypol is (200-50):1.

[0007] The composition can be used to control lepidopteran pests, especially lepidopteran pests that harm rice, such as the rice stem borer, the rice yellow stem borer, the rice stem borer, and the rice leaf folder.

[0008] The above composition may also include other active ingredients, such as organophosphorus, carbamates, pyrethroids, nereistoxins, macrolides, antibiotics, insect growth regulators, neonicotinoids, bisamides, sulfoximines, pyridineamides, pyrimidones, semicarbazones, pyridine imines, phenylpyrazoles, pyrroles, oxadiazines, botanicals, and microorganisms in insecticides; such as triazoles, amides, benzimidazoles, strobilurins, organophosphorus, organosulfur, carbamates, oxazoles, pyrroles, imidazoles, antibiotics, inducers, and microorganisms in fungicides; and plant growth regulators. These active ingredients may be one or a combination of the above.

[0009] Further, the insecticide that may be included is selected from chlorpyrifos, phoxim, profenofos, phoxim, diazinon, triazophos, malathion, quinalphos, acephate, trichlorfon, fenitrothion, fenthion, methomyl, fumaric acid, carbosulfan, deltamethrin, beta-cypermethrin, thiophanate, thiophanate-methyl, emamectin, spinosad, ethyl spinosad, lufenuron, chlorfluazuron, hexaflumuron, tebufenozide, methoxyfenozide, chlorpyrifos, One or more of furanfenozide, buprofen, imidacloprid, acetamiprid, thiacloprid, thiamethoxam, clothianidin, dinotefuran, nitenpyram, flupyfuranone, flubendiamide, cyantraniliprole, tetrachlorfenapyr, tetrazobactam, thiofenapyr, bromobendan, isoxazole, sulfoxaflor, flonicamid, trifluanid, metaflumizone, pymetrozine, fipronil, butafenib, chlorfenapyr, indoxacarb, azadirachtin or Bacillus thuringiensis (Bt).

[0010] Further, the fungicide that can be included is selected from tricyclazole, triadimefon, epoxiconazole, hexaconazole, tebuconazole, triadimenol, propiconazole, fenbuconazole, difenoconazole, picroconazole, tetrafluconazole, metalaxyl, metalaxyl-M, thiofuran, blastamide, cyproconazole, cyanamide, dichlorocyanamide, thiamethoxam, carboxin, fluazifop-butyl, isothiocyanate, carbendazim, methyl thiophanate, prothioazole, azoxystrobin, trifloxystrobin, picoxystrobin , pyraclostrobin, rice blast net, rice blast net, dichlorvos, methyl tolclofos, thiram, mancozeb, sulfamethoxam, oxadix, fludioxonil, prochloraz, prochloraz manganese salt, rice blast, Jinggangmycin, kasugamycin, shenqinmycin, Ningnanmycin, tetramycin, polyoxin, pyrimidine nucleoside antibiotics, allylbenzimidazole, amino oligosaccharides, oligosaccharides, Bacillus subtilis, Bacillus cereus or Bacillus amyloliquefaciens One or more of the group.

[0011] Preferably, the insecticide is selected from one or more of chlorpyrifos, cartap, emamectin benzoate, spinosad, ethyl spinosad, tebufenozide, methoxyfenozide, thiamethoxam, nitenpyram, flupyrad, flubendiamide, cyanamide, tetrachlorfenapyr, tetrazobactam, thiobencarb, bromobenzuron, isoxazole terpenoid, sulfoxaflor, flonicamid, trifluanid, metaflumizone, pymetrozine, fipronil, cypermethrin and indoxacarb.

[0012] Preferably, the fungicide is selected from one or more of hexaconazole, propiconazole, tetrafluconazole, pyraclostrobin, cyproconazole, cyanamide, dichlorocyanamide, thiazolinone, fluazifop, myclobutanil, pyraclostrobin, pyraclostrobin, fludioxonil, prochloraz, prochloraz manganese salt and pyraclostrobin.

[0013] The above composition may contain other inert ingredients for stabilizing the active ingredients and facilitating their application to crops or attachment to targets, such as fillers, wetting agents, dispersants, defoaming agents, antifreeze agents, solvents, emulsifiers, preservatives, disintegrants, etc.

[0014] The above-mentioned composition can be processed by the methods commonly used in the prior art. Preferred dosage forms include suspensions, oil suspensions, granules, large granules, microcapsule suspensions, wettable powders, water-dispersible granules, emulsifiable concentrates, water emulsions, microemulsions, seed coatings, seed treatment suspensions, seed treatment microcapsule suspensions, seed treatment dispersible powders, and seed treatment liquids.

[0015] The present invention has the following advantages:

[0016] The composition provided by the present invention can significantly reduce the amount of chlorantraniliprole used as the active ingredient for controlling rice stem borers when using an extremely low dose of gossypol, thereby improving the efficacy of the drug. Gossypol is low in cost and can be used in small amounts in the composition, making it suitable for use as a highly effective synergistic adjuvant. The composition of the present invention has a good control effect on rice stem borers, can reduce the application dose of chlorantraniliprole, and lowers control costs, making it suitable for practical production use. DETAILED DESCRIPTION

[0017] The present invention will be further described below with reference to the examples, but the present invention is not limited by the following examples.

[0018] Example 1 Indoor Toxicity of Chlorantraniliprole and Gossypol to Chilo suppressalis

[0019] First-generation rice stem borer larvae were collected in Yutai County, Jining City. After they emerged from the womb in the laboratory, the egg masses were placed on artificial diet and raised to the third instar. The toxicity test was conducted using the artificial diet medicated film method:

[0020] Chlorantraniliprole was prepared with dimethylformamide (DMF) to prepare a mother solution of a certain concentration, which was then diluted with a 0.1wt% Triton-100 solution to prepare a series of treatment solutions of five concentrations. Gossypol acetate was dissolved in acetone to prepare a mother solution, which was then diluted with a 0.1wt% Triton-100 solution to prepare a series of treatment solutions of five concentrations. A mixture of chlorantraniliprole and gossypol acetate was prepared as follows: during the preparation of the series of chlorantraniliprole solutions, gossypol acetate was added to achieve a mass ratio of 1000:1, 500:1, 200:1, 100:1, and 50:1. The concentration of chlorantraniliprole in the mixture was consistent with that of the single agent.

[0021] The preparation of artificial feed refers to the method of Liu Huimin, Han and others. After the preparation is completed, put an appropriate amount of artificial feed into the 24-well plate while it is still hot, and ensure that the surface of the feed is flat, without bubbles, and without gaps between the feed and the hole wall after the feed condenses, so as to avoid the hole mouth and the hole wall being stained with feed residues. According to the concentration of the agent from low to high, a certain amount of liquid medicine is drawn and added to the 24-well plate where the artificial feed has been placed, 100 μL per well, and the DMF concentration of the highest chlorantraniliprole solution, Triton-100 solution (0.1wt%), is used as a control. It is naturally air-dried and set aside. 20 larvae were treated each time and repeated 3 times. After treatment, it was placed in an artificial climate box with a relative temperature of (26±1)℃, a relative humidity of 60%-80%, and a light cycle of L:D=14:10. The number of dead insects was investigated 72 hours after treatment; the toxicity regression equation and R were established using SPSS data processing software. 2 , LC 50 and 95% confidence limits, calculate the synergistic ratio (LC 50 / LC of the reagent after adding synergist 50 ).

[0022] Table 1 Combined toxicity of chlorantraniliprole and gossypol to Chilo suppressalis

[0023]

[0024] From the results in Table 1, we can see that the LC values ​​of chlorantraniliprole and gossypol acetate on Chilo suppressalis are 50 The LC1 of gossypol acetate is 5.091 mg / L. Since the maximum gossypol content at the highest chlorantraniliprole concentration is only 4 mg / L, gossypol acetate is used as a synergist. The synergistic ratio shows that within a chlorantraniliprole to gossypol acetate mass ratio of 1000:1-500:1, the synergistic effect is minimal due to the low gossypol content. When the gossypol acetate ratio is increased to 200:1-100:1, a significant synergistic effect is observed. Further increases in the gossypol acetate ratio do not significantly improve the synergistic ratio.

[0025] Example 2 Indoor Toxicity of Chlorantraniliprole and Gossypol to Rice Borer

[0026] Overwintering mature larvae collected from rice fields at the Jinan Experimental Base of the Shandong Academy of Agricultural Sciences were placed under suitable conditions to break diapause, pupate, and emerge. The adults were then transferred to oviposition cages containing tillering rice seedlings to lay eggs. Rice leaf sheaths containing eggs of the greater stem borer were excised and placed in Petri dishes lined with moist filter paper. After the eggs hatched, they were reared on artificial diet until they reached the third instar. Toxicity testing was then conducted using the feed smear method.

[0027] Chlorantraniliprole was prepared in DMF to a stock solution of a certain concentration, which was then diluted with a 0.1wt% Triton-100 solution to produce a series of five treatment solutions. Acetic gossypol was dissolved in acetone to prepare a stock solution, which was then diluted with a 0.1wt% Triton-100 solution to produce a series of five treatment solutions. A mixture of chlorantraniliprole and acetic gossypol was prepared as follows: during the preparation of the chlorantraniliprole solutions, acetic gossypol was added to achieve a mass ratio of 1000:1, 500:1, 200:1, 100:1, and 50:1. The concentration of chlorantraniliprole in the mixture was the same as that of the single agent.

[0028] Artificial feed was prepared according to the report of Zhang Hongtao et al. from the Chinese Academy of Agricultural Sciences. After preparation, put an appropriate amount of artificial feed into a 24-well plate while it is still hot, and ensure that the surface of the feed is flat, without bubbles, and without gaps between the feed and the well wall after condensation, so as to avoid feed residues on the well mouth and well wall. According to the concentration of the agent from low to high, a certain amount of liquid medicine was aspirated and added to the 24-well plate where the artificial feed has been placed, 100 μL per well, and the DMF concentration of Triton-100 solution (0.1wt%) in the highest chlorantraniliprole solution was used as a control, and the plates were naturally air-dried for later use. 20 larvae were treated for each treatment, and the treatment was repeated 3 times. After treatment, the plates were placed in an artificial climate box with a relative temperature of (26±1)℃, a relative humidity of 60%-80%, and a light cycle of L:D=14:10. The number of dead insects was investigated 72 hours after treatment; the toxicity regression equation and R were established using SPSS data processing software. 2 , LC 50 and 95% confidence limits to calculate the effectiveness ratio.

[0029] Table 2 Combined toxicity of chlorantraniliprole and gossypol to rice borer

[0030]

[0031] The results in Table 2 show that the LC values ​​of chlorantraniliprole and gossypol acetate on rice borer are 50 The synergistic effect is limited when the chlorantraniliprole to gossypol acetic acid mass ratio is between 1000:1 and 500:1, due to the low gossypol content. When the gossypol acetic acid mass ratio is increased to between 200:1 and 50:1, a significant synergistic effect is observed, and the synergistic ratio increases with increasing gossypol content.

[0032] Example 3 Indoor Toxicity of Chlorantraniliprole and Gossypol to Rice Leaf Folder

[0033] Adult rice leaf rollers were trapped using black light in rice fields at the Jining Rice Experimental Base of the Shandong Academy of Agricultural Sciences. Paired adults were transferred to ovipositors containing tillering rice seedlings for egg laying. Nutrition was supplemented with 10% honey water, and the seedlings were replaced daily. The oviposited rice seedlings were incubated in an artificial climate chamber at a relative humidity of (26 ± 1)°C, a relative humidity of 60%-80%, and a photoperiod of L:D = 14:10. After the egg masses hatched, toxicity was determined using the rice seedling immersion method.

[0034] Chlorantraniliprole was prepared in DMF to a stock solution of a certain concentration, which was then diluted with a 0.1wt% Triton-100 solution to produce a series of five treatment solutions. Acetic gossypol was dissolved in acetone to prepare a stock solution, which was then diluted with a 0.1wt% Triton-100 solution to produce a series of five treatment solutions. A mixture of chlorantraniliprole and acetic gossypol was prepared as follows: during the preparation of the chlorantraniliprole solutions, acetic gossypol was added to achieve a mass ratio of 1000:1, 500:1, 200:1, 100:1, and 50:1. The concentration of chlorantraniliprole in the mixture was the same as that of the single agent.

[0035] Rice seedlings about 25 cm tall were immersed in the test solution for 30 seconds. After natural drying, the leaves were cut into 5-6 cm small segments and placed in a moisturizing culture dish. 20 already silken rice leaf roller larvae were picked with a brush and placed on the rice leaves in the culture dish. The opening was tied with gauze. Each treatment was repeated 3 times. After treatment, the rice seedlings were placed in an artificial climate chamber with a relative temperature of (26 ± 1) ° C, a relative humidity of 60%-80%, and a light cycle of L:D = 14:10. The number of dead insects was counted 5 days after treatment. The toxicity regression equation and R were established using SPSS data processing software. 2 , LC 50 and 95% confidence limits to calculate the effectiveness ratio.

[0036] Table 3 Combined toxicity of chlorantraniliprole and gossypol to rice leaf folder

[0037]

[0038] The results in Table 3 show that the LC values ​​of chlorantraniliprole and gossypol acetate against Cnaphalocrocis medinalis are 50 The synergistic effect of chlorantraniliprole and gossypol acetate is 3.440 mg / L and 102.813 mg / L, respectively. Since the maximum gossypol content at the highest chlorantraniliprole concentration is only 0.5 mg / L, the theoretical mortality rate of rice leaf rollers at this concentration is less than 1%. Therefore, gossypol acetate is used as a synergist. The synergistic effect is limited when the mass ratio of chlorantraniliprole to gossypol acetate is 1000:1 due to the low gossypol content. When the gossypol acetate ratio is increased to the range of 500:1-50:1, a significant synergistic effect is observed, and the synergistic effect increases with the increase in the gossypol ratio. In particular, when the ratio is between 200:1-50:1, the synergistic effect is greater than 1.2.

[0039] Example 4 Preparation of chlorantraniliprole suspension concentrate containing gossypol

[0040] The raw materials were weighed according to the following mass percentages: chlorantraniliprole 20%; gossypol acetate 0.2%; dispersant: styrene-maleic anhydride copolymer, 2.5%; wetting agent: polyether F-68, 1.5%; sodium polyoxyethylene ether sulfosuccinate, 1.5%; filler: white carbon black, 0.1%; titanium dioxide 0.1%, zinc oxide 0.1%; thickener: xanthan gum, 0.1%; preservative: isothiazolinone, 0.1%; silicone defoamer, 0.2%; the balance was water;

[0041] Water, a wetting agent, a dispersant, a defoaming agent, a preservative, and a filler are shear-mixed, and then gossypol and chlorantraniliprole are added; then, zirconium beads are ground, and then a thickener is added and shear-mixed to obtain a 20% chlorantraniliprole suspension containing gossypol.

[0042] At the same time, a 20% suspension concentrate containing only chlorantraniliprole was prepared according to the above method.

[0043] Example 5 Field efficacy of chlorantraniliprole suspension concentrate containing gossypol against rice borers

[0044] A field trial of a chlorantraniliprole suspension concentrate containing gossypol for controlling rice stem borers was conducted at the Jining Experimental Base of the Institute of Wetland Agriculture and Ecology, Shandong Academy of Agricultural Sciences. The rice variety was Shengdao 18, growing at the heading stage, and the previous crop was wheat. The chlorantraniliprole suspension concentrate containing gossypol was tested at three concentrations: high, medium, and low. A chlorantraniliprole suspension concentrate containing only chlorantraniliprole was used as the control, and water was used as a blank control. The experimental plots were arranged longitudinally in randomized blocks, with a plot area of ​​20 m2. 2 Repeat 4 times. According to 450L / hm 2 The liquid was sprayed using a MATABI 9-type round sprayer equipped with a conical nozzle at a pressure of 1.5 bar. Thirty days after application, the number of plants and the number of dead hearts (white ears) were counted and examined. All plants infested with borers were stripped and the number of live insects was counted. The dead heart (white ears) rate, leaf curl rate, control efficacy, and insect population control efficacy were calculated using the following formulas:

[0045] Dead heart (white ear) rate (%) = number of dead heart (white ear) / total number of surveyed plants × 100;

[0046] Leaf curling rate (%) = number of leaves curled by borers / total number of leaves surveyed × 100

[0047] Preventive effect (%) = (CK-PT) / CK×100;

[0048] Where: CK is the rate of dead heart (white ear) or curled leaves after drug application in the blank control area;

[0049] PT - the rate of dead heart (white ear) or curled leaves in the treated area;

[0050] Insect control efficacy (%) = (number of live insects in the control area - number of live insects in the treatment area) / number of live insects in the control area × 100;

[0051] The experimental data were analyzed using SPSS software, and Duncan's new multiple range method was used for multiple comparisons. Different letters after the data in the same column indicate significant differences. Lowercase letters represent significant differences at P < 0.05, and uppercase letters represent significant differences at P < 0.01.

[0052] Table 4 Field control results of Chilo suppressalis and Sesamina inferens

[0053]

[0054] Table 5 Field control results of rice leaf roller

[0055]

[0056] Tables 4 and 5 show that the addition of gossypol to a 20% chlorantraniliprole suspension concentrate (SC) showed significant control efficacy against rice stem borers. The efficacy of each treatment increased with increasing SC concentration. Thirty days after application, the overall control efficacy against Chilo suppressalis and Sesamia inferens ranged from 69.61% to 91.44%, and against Cnaphalocrocis medinalis ranged from 74.62% to 89.57%. The active ingredient dosage after adding gossypol was 30 g / hm2. 2 45g / hm2 when not added 2 The control efficacy of chlorantraniliprole was comparable, with no significant difference. Chlorantraniliprole entered the domestic market in 2010. As the application time increases, the control effect of this agent on rice stem borers decreases; the maximum dosage for controlling rice stem borers in the agent's instructions is 30g / hm2. 2 In this experiment, the 20% chlorantraniliprole suspension concentrate was used at an active ingredient dosage of 45 g / hm2. 2 The control efficacy is about 80%, which shows that the agent has developed a certain level of drug resistance; and the addition of gossypol can reduce the dosage of active ingredients and improve the control effect on rice borers.

Claims

1. A composition containing chlorantraniliprole, characterized in that: The invention comprises chlorantraniliprole and gossypol, and the mass ratio of chlorantraniliprole to gossypol is (1000-50):

1.

2. The composition according to claim 1, characterized in that The mass ratio of chlorantraniliprole to cottonypol is (200-50):

1.

3. The composition according to claim 1, characterized in that The control target of the composition is lepidopteran pests; preferably rice lepidopteran pests, such as the rice stem borer, the rice yellow stem borer, the rice borer and the rice leaf folder.

4. The composition according to claim 1, characterized in that The composition may also include other active ingredients.

5. The composition according to claim 4, characterized in that The other active ingredients are selected from one or more of pesticides, fungicides and plant growth regulators.

6. The composition according to claim 4, characterized in that Other active ingredients are selected from organophosphates, carbamates, pyrethroids, nereistoxins, macrolides, antibiotics, insect growth regulators, neonicotinoids, diamides, sulfoximines, pyridineamides, pyrimidone, semicarbazones, pyridine imines, phenylpyrazoles, pyrroles, oxadiazines, botanicals, and microorganisms in insecticides; Triazoles, amides, benzimidazoles, methoxyacrylates, organophosphorus, organosulfur, carbamates, oxazoles, pyrroles, imidazoles, antibiotics, inducers, and microorganisms in fungicides.

7. The composition according to claim 5, characterized in that The insecticide is selected from chlorpyrifos, phoxim, profenofos, phoxim, diazinon, triazophos, malathion, quinalphos, acephate, trichlorfon, fenitrothion, dapoxetine, methomyl, fenbutyl, carbosulfan, deltamethrin, high-efficiency cypermethrin, insecticide, insect ring, cartap, emamectin benzoate, avermectin, spinosad, ethyl spinosad, lufenuron, chlorpyrifos, hexaflumuron, fenvalerate, methoxyfenozide, chlorfenapyr, furamectin One or more of hydrazide, buprofezin, imidacloprid, acetamiprid, thiacloprid, thiamethoxam, clothianidin, dinotefuran, nitenpyram, flupyfuranone, flubendiamide, cyantraniliprole, tetrachlorantraniliprole, tetrazolyl wormamide, thiobencarb, bromobendandiamide, isoxazole wormamide, sulfoxaflor, flonicamid, trifluanid, metaflumizone, pymetrozine, fipronil, butyronitrile, cypermethrin, indoxacarb, azadirachtin or Bacillus thuringiensis; The fungicide is selected from tricyclazole, triadimefon, fluopicolide, hexaconazole, tebuconazole, triadimenol, propiconazole, nitrobenazole, difenoconazole, cyproconazole, tetrafluconazole, metalaxyl, metalaxyl-M, thiofuran, rice blastamide, cyproconazole, cyanamide, dichlorocyanamide, thiocarbamide, carboxin, fluoxazolidinone, isothiocarbamide, carbendazim, methyl thiophanate, prothioazole, azoxystrobin, trifloxystrobin, picoxystrobin, pyraclostrobin One or more of ester, rice blast net, isobarbital, dichlorvos, methyl tolclofos, thiram, mancozeb, sulfamethoxam, oxazolidinone, prochloraz, prochloraz manganese salt, rice blast, Jinggangmycin, kasugamycin, shenqinmycin, Ningnanmycin, tetramycin, polyoxin, pyrimidine nucleoside antibiotics, allylbenzazole, amino oligosaccharides, oligosaccharides, Bacillus subtilis, Bacillus cereus or Bacillus amyloliquefaciens.

8. The composition according to claim 5, characterized in that The insecticide is selected from one or more of chlorpyrifos, cartap, emamectin benzoate, spinosad, ethyl spinosad, fenbumid, methoxyfenbumid, thiamethoxam, nitenpyram, flupyrazone, flubendiamide, cyantraniliprole, tetrachlorantraniliprole, tetrazobactam, thiobencarb, bromobendan, isoxazole wormamide, sulfoxaflor, flonicamid, flonicamid, trifluanid, metaflumizone, pymetrozine, fipronil, cypermethrin and indoxacarb; The fungicide is selected from one or more of hexaconazole, propiconazole, tetrafluconazole, rice blast amide, cyproconazole, cyanamide, dichlorocyanamide, thiamethoxam, fluazifop, myclobutanil, pyraclostrobin, rice blast net, isocyanurate, fludioxonil, prochloraz, prochloraz manganese salt and rice blast spirit.

9. The composition according to claim 1, characterized in that The composition may contain other inert ingredients, such as fillers, wetting agents, dispersants, defoamers, antifreeze agents, solvents, emulsifiers, preservatives, disintegrants and the like.

10. The composition according to claim 1, characterized in that The dosage form of the composition is selected from suspension, oil suspension, granule, large granule, microcapsule suspension, wettable powder, water dispersible granule, emulsifiable concentrate, water emulsion, microemulsion, seed coating agent, seed treatment suspension, seed treatment microcapsule suspension, seed treatment dispersible powder or seed treatment liquid.

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