Graphene oxide-based hormone adsorption composition

Abstract

The present application relates to a hormone adsorption composition comprising graphene oxide. The hormone adsorption composition according to embodiments of the present application can be used, due to graphene oxide exhibiting hormone adsorption ability, for preventing, alleviating, or treating problems caused by the excess secretion of hormones in the body in the fields of cosmetics, quasi-drugs, and medicines.

Description

Hormone adsorption composition based on graphene oxide

[0001] The present invention relates to a composition for hormone absorption, comprising graphene oxide.

[0002] Since its introduction in 2004, graphene has attracted attention across diverse fields, including physics, chemistry, mechanics, and electrical engineering, for its outstanding properties, including high electrical and thermal conductivity and superior mechanical strength. Early graphene research focused on developing transparent, flexible electrodes that could maximize these properties. This effort has expanded into broader fields through the synthesis and application of large-area graphene films using chemical vapor deposition, a research effort that continues to this day. Subsequently, research has demonstrated that graphene-based materials possess diverse properties that can be utilized in biology and medicine, leading to ongoing research and development efforts to realize this potential.

[0003] [Prior Art Literature]

[0004] [Non-patent literature]

[0005] Kim, Mi-Gyeong; Y. Park, Joo; Shon, Yuna; Shim, Gayong; Oh, Yu-Kyoung, "Pharmaceutical Applications of Graphene-based Nanosheets", Current Pharmaceutical Biotechnology, Volume 14, Number 12, 2013, pp. 1016-1026(11)

[0006] The present invention seeks to provide a hormone adsorption composition comprising graphene oxide.

[0007] However, the problems that the present invention seeks to solve are not limited to the problems mentioned above, and other problems not mentioned will be clearly understood by those skilled in the art from the description below.

[0008] The first aspect of the present invention provides a composition for hormone absorption, comprising graphene oxide.

[0009] The second aspect of the present invention provides a cosmetic composition for hormone absorption, comprising graphene oxide.

[0010] The third aspect of the present invention provides a pharmaceutical composition for hormone absorption, comprising graphene oxide.

[0011] The fourth aspect of the present invention provides a pharmaceutical composition for hormone absorption, comprising graphene oxide.

[0012] The hormone-absorbing composition according to the embodiments of the present invention has the characteristic that, since graphene oxide exhibits hormone-absorbing ability, it can be used in the fields of cosmetics, over-the-counter drugs, and pharmaceuticals to prevent, improve, or treat problems caused by excessive hormone secretion in the body.

[0013] Figure 1 shows the results of evaluating the testosterone adsorption capacity of PDDA salt-functionalized graphene oxide in one embodiment of the present invention.

[0014] Hereinafter, with reference to the attached drawings, implementation examples and embodiments of the present invention will be described in detail so that those skilled in the art can easily practice the present invention. However, the present invention may be implemented in various different forms and is not limited to the implementation examples and embodiments described herein. In addition, in the drawings, parts irrelevant to the description have been omitted to clearly explain the present invention, and similar parts have been designated with similar drawing reference numerals throughout the specification.

[0015] Throughout this specification, when a part is said to be "connected" to another part, this includes not only cases where it is "directly connected" but also cases where it is "electrically connected" with another element in between.

[0016] Throughout this specification, when it is said that an element is "on" another element, this includes not only cases where the element is in contact with the other element, but also cases where another element exists between the two elements.

[0017] Throughout this specification, whenever a part is said to "include" a component, this does not mean that it excludes other components, but rather that it may include other components, unless otherwise specifically stated.

[0018] The terms "about," "substantially," and the like used in this specification are used in a meaning that is at or close to the numerical value when manufacturing and material tolerances inherent in the meanings mentioned are presented, and are used to prevent unscrupulous infringers from unfairly exploiting the disclosure in which exact or absolute values ​​are mentioned to aid understanding of the present application.

[0019] The terms “step of” or “step of” as used throughout this specification do not mean “step for”.

[0020] Throughout this specification, the term "combination(s) thereof" included in the expressions in the Makushi format means one or more mixtures or combinations selected from the group consisting of the components described in the expressions in the Makushi format, and means including one or more selected from the group consisting of said components.

[0021] Throughout this specification, references to “A and / or B” mean “A or B, or A and B.”

[0022] Throughout this specification, the “diameter” of graphene oxide means the length of the longest line passing through the center of the graphene oxide particle from one end of the graphene oxide particle to the other.

[0023] Throughout this specification, the “average diameter” of graphene oxide means the average value of the diameter distribution of graphene oxide.

[0024] Below, the implementation examples of the present invention are described in detail, but the present invention may not be limited thereto.

[0025] The first aspect of the present invention provides a composition for hormone absorption, comprising graphene oxide.

[0026] In one embodiment of the present invention, in one embodiment of the present invention, the average diameter of the graphene oxide is about 1 nm or more, about 10 nm or more, about 30 nm or more, about 50 nm or more, about 70 nm or more, about 90 nm or more, about 100 nm or more, about 150 nm or more, about 200 nm or more, about 250 nm or more, about 300 nm or more, about 350 nm or more, about 400 nm or more, about 450 nm or more, about 500 nm or more, about 550 nm or more, about 600 nm or more, about 650 nm or more, about 700 nm or more, about 750 nm or more, about 800 nm or more, about 850 nm or more, about 900 nm or more, about 950 nm or more, about 1,000 nm or more, about 1,100 nm or more, about 1,500 nm or more, or about It can be more than 2,000 nm.

[0027] In one embodiment of the present invention, in one embodiment of the present invention, the average diameter of the graphene oxide may be about 2,000 nm or less, about 1,500 nm or less, about 1,100 nm or less, about 1,000 nm or less, about 950 nm or less, about 900 nm or less, about 850 nm or less, about 800 nm or less, about 750 nm or less, about 700 nm or less, about 650 nm or less, about 600 nm or less, about 550 nm or less, about 500 nm or less, about 450 nm or less, about 400 nm or less, about 350 nm or less, about 300 nm or less, about 250 nm or less, about 200 nm or less, about 150 nm or less, or about 100 nm or less.

[0028] In one embodiment of the present invention, the average diameter of the graphene oxide is from about 1 nm to about 2,000 nm, from about 1 nm to about 1,500 nm, from about 1 nm to about 1,000 nm, from about 1 nm to about 950 nm, from about 1 nm to about 900 nm, from about 1 nm to about 850 nm, from about 1 nm to about 800 nm, from about 1 nm to about 750 nm, from about 1 nm to about 700 nm, from about 1 nm to about 650 nm, from about 1 nm to about 600 nm, from about 1 nm to about 550 nm, from about 1 nm to about 500 nm, from about 1 nm to about 450 nm, from about 1 nm to about 400 nm, from about 1 nm to about 350 nm, from about 1 nm to about 300 nm, from about 1 nm to about 250 nm, from about 1 nm to About 200 nm, about 1 nm to about 150 nm, about 1 nm to about 100 nm, about 10 nm to about 2,000 nm, about 10 nm to about 1,500 nm, about 10 nm to about 1,000 nm, about 10 nm to about 950 nm, 10 nm to about 900 nm, about 10 nm to about 850 nm, about 10 nm to about 800 nm, about 10 nm to about 750 nm, about 10 nm to about 700 nm, about 10 nm to about 650 nm, about 10 nm to about 600 nm, about 10 nm to about 550 nm, about 10 nm to about 500 nm, about 10 nm to about 450 nm, about 10 nm to about 400 nm, about 10 nm to about 350 nm, about 10 nm to about 300 nm, about 10 nm to about 250 nm, about 10 nm to about 200 nm, about 10 nm to about 150 nm, about 10 nm to about 100 nm, about 30 nm to about 2,000 nm, about 30 nm to about 1,500 nm, about 30 nm to about 1,000 nm, about 30 nm to about 950 nm,About 30 nm to about 900 nm, about 30 nm to about 850 nm, about 30 nm to about 800 nm, about 30 nm to about 750 nm, about 30 nm to about 700 nm, about 30 nm to about 650 nm, about 30 nm to about 600 nm, about 30 nm to about 550 nm, about 30 nm to about 500 nm, about 30 nm to about 450 nm, about 30 nm to about 400 nm, about 30 nm to about 350 nm, about 30 nm to about 300 nm, about 30 nm to about 250 nm, about 30 nm to about 200 nm, about 30 nm to about 150 nm, about 30 nm to about 100 nm, about 50 nm to about 2,000 nm, about 50 nm to about 1,500 nm, about 50 nm to about 1,000 nm, about 50 nm to about 950 nm, about 50 nm to about 900 nm, about 50 nm to about 850 nm, about 50 nm to about 800 nm, about 50 nm to about 750 nm, about 50 nm to about 700 nm, about 50 nm to about 650 nm, about 50 nm to about 600 nm, about 50 nm to about 550 nm, about 50 nm to about 500 nm, about 50 nm to about 450 nm, about 50 nm to about 400 nm, about 50 nm to about 350 nm, about 50 nm to about 300 nm, about 50 nm to about 250 nm, about 50 nm to about 200 nm, about 50 nm to about 150 nm, about 50 nm to about 100 nm, about 70 nm to about 2,000 nm, about 70 nm to about 1,500 nm, about 70 nm to about 1,000 nm, about 70 nm to about 950 nm, about 70 nm to about 900 nm, about 70 nm to about 850 nm, about 70 nm to about 800 nm, about 70 nm to about 750 nm, about 70 nm to about 700 nm,About 70 nm to about 650 nm, about 70 nm to about 600 nm, about 70 nm to about 550 nm, about 70 nm to about 500 nm, about 70 nm to about 450 nm, about 70 nm to about 400 nm, about 70 nm to about 350 nm, about 70 nm to about 300 nm, about 70 nm to about 250 nm, about 70 nm to about 200 nm, about 70 nm to about 150 nm, about 70 nm to about 100 nm, about 90 nm to about 2,000 nm, about 90 nm to about 1,500 nm, about 90 nm to about 1,000 nm, about 90 nm to about 950 nm, about 90 nm to about 900 nm, about 90 nm to about 850 nm, about 90 nm to about 800 nm, about 90 nm to about 750 nm, about 90 nm to about 700 nm, about 90 nm to about 650 nm, about 90 nm to about 600 nm, about 90 nm to about 550 nm, about 90 nm to about 500 nm, about 90 nm to about 450 nm, about 90 nm to about 400 nm, about 90 nm to about 350 nm, about 90 nm to about 300 nm, about 90 nm to about 250 nm, about 90 nm to about 200 nm, about 90 nm to about 150 nm, about 90 nm to about 100 nm, about 100 nm to about 2,000 nm, about 100 nm to about 1,500 nm, about 100 nm to about 1,000 nm, about 100 nm to about 950 nm, about 100 nm to about 900 nm, about 100 nm to about 850 nm, about 100 nm to about 800 nm, about 100 nm to about 750 nm, about 100 nm to about 700 nm, about 100 nm to about 650 nm, about 100 nm to about 600 nm, about 100 nm to about 550 nm, about 100 nm to about 500 nm,About 100 nm to about 450 nm, about 100 nm to about 400 nm, about 100 nm to about 350 nm, about 100 nm to about 300 nm, about 100 nm to about 250 nm, about 100 nm to about 200 nm, about 100 nm to about 150 nm, about 150 nm to about 2,000 nm, about 150 nm to about 1,500 nm, about 150 nm to about 1,000 nm, about 150 nm to about 950 nm, about 150 nm to about 900 nm, about 150 nm to about 850 nm, about 150 nm to about 800 nm, about 150 nm to about 750 nm, about 150 nm to about 700 nm, about 150 nm to about 650 nm, about 150 nm to about 600 nm, about 150 nm to about 550 nm, about 150 nm to about 500 nm, about 150 nm to about 450 nm, about 150 nm to about 400 nm, about 150 nm to about 350 nm, about 150 nm to about 300 nm, about 150 nm to about 250 nm, about 150 nm to about 200 nm, about 200 nm to about 2,000 nm, about 200 nm to about 1,500 nm, about 200 nm to about 1,000 nm, about 200 nm to about 950 nm, about 200 nm to about 900 nm, about 200 nm to about 850 nm, about 200 nm to about 800 nm, about 200 nm to about 750 nm, About 200 nm to about 700 nm, about 200 nm to about 650 nm, about 200 nm to about 600 nm, about 200 nm to about 550 nm, about 200 nm to about 500 nm, about 200 nm to about 450 nm, about 200 nm to about 400 nm, about 200 nm to about 350 nm, about 200 nm to about 300 nm, about 200 nm to about 250 nm, about 250 nm to about 2,000 nm, about 250 nm to about 1,500 nm, about 250 nm to about 1,000 nm, about 250 nm to about 950 nm, about 250 nm to about 900 nm, about 250 nm to about 850 nm, about 250 nm to about 800 nm, about 250 nm to about 750 nm, about 250 nm to about 700 nm, about 250 nm to about 650 nm, about 250 nm to about 600 nm, about 250 nm to about 550 nm, about 250 nm to about 500 nm, about 250 nm to about 450 nm, about 250 nm to about 400 nm, about 250 nm to about 350 nm, about 250 nm to about 300 nm, about 300 nm to about 2,000 nm, about 300 nm to about 1,500 nm, about 300 nm to about 1,000 nm, about 300 nm to about 950 nm, about 300 nm to about 900 nm, about 300 nm to about 850 nm, about 300 nm to about 800 nm, about 300 nm to about 750 nm, about 300 nm to about 700 nm, about 300 nm to about 650 nm, about 300 nm to about 600 nm, about 300 nm to about 550 nm, about 300 nm to about 500 nm, about 300 nm to about 450 nm, about 300 nm to about 400 nm, about 300 nm to about 350 nm, about 350 nm to about 2,000 nm, about 350 nm to about 1,500 nm, about 350 nm to about 1,000 nm, about 350 nm to about 950 nm, about 350 nm to about 900 nm, about 350 nm to about 850 nm, about 350 nm to about 800 nm, about 350 nm to about 750 nm, about 350 nm to about 700 nm, about 350 nm to about 650 nm, about 350 nm to about 600 nm, about 350 nm to about 550 nm,About 350 nm to about 500 nm, about 350 nm to about 450 nm, about 350 nm to about 400 nm, about 400 nm to about 2,000 nm, about 400 nm to about 1,500 nm, about 400 nm to about 1,000 nm, about 400 nm to about 950 nm, about 400 nm to about 900 nm, about 400 nm to about 850 nm, about 400 nm to about 800 nm, about 400 nm to about 750 nm, about 400 nm to about 700 nm, about 400 nm to about 650 nm, about 400 nm to about 600 nm, about 400 nm to about 550 nm, about 400 nm to about 500 nm, about 400 nm to about 450 nm, about 450 nm to about 2,000 nm, about 450 nm to about 1,500 nm, about 450 nm to about 1,000 nm, about 450 nm to about 950 nm, about 450 nm to about 900 nm, about 450 nm to about 850 nm, about 450 nm to about 800 nm, about 450 nm to about 750 nm, about 450 nm to about 700 nm, about 450 nm to about 650 nm, about 450 nm to about 600 nm, about 450 nm to about 550 nm, about 450 nm to about 500 nm, about 500 nm to about 2,000 nm, about 500 nm to about 1,500 nm, about 500 nm to about 1,000 nm, about 500 nm to about 950 nm, about 500 nm to about 900 nm, about 500 nm to about 850 nm, about 500 nm to about 800 nm, about 500 nm to about 750 nm, about 500 nm to about 700 nm, about 500 nm to about 650 nm, about 500 nm to about 600 nm, about 500 nm to about 550 nm, about 550 nm to about 2,000 nm, about 550 nm to about 1,500 nm,About 550 nm to about 1,000 nm, about 550 nm to about 950 nm, about 550 nm to about 900 nm, about 550 nm to about 850 nm, about 550 nm to about 800 nm, about 550 nm to about 750 nm, about 550 nm to about 700 nm, about 550 nm to about 650 nm, about 550 nm to about 600 nm, about 600 nm to about 2,000 nm, about 600 nm to about 1,500 nm, about 600 nm to about 1,000 nm, about 600 nm to about 950 nm, about 600 nm to about 900 nm, about 600 nm to about 850 nm, about 600 nm to about 800 nm, about 600 nm to about 750 nm, about 600 nm to about 700 nm, about 600 nm to about 650 nm, about 600 nm to about 600 nm, about 600 nm to about 550 nm, about 650 nm to about 2,000 nm, about 650 nm to about 1,500 nm, about 650 nm to about 1,000 nm, about 650 nm to about 950 nm, about 650 nm to about 900 nm, about 650 nm to about 850 nm, about 650 nm to about 800 nm, about 650 nm to about 750 nm, about 650 nm to about 700 nm, about 700 nm to about 2,000 nm, about 700 nm to about 1,500 nm, about 700 nm to about 1,000 nm, about 700 nm to about 950 nm, about 700 nm to about 900 nm, about 700 nm to about 850 nm, about 700 nm to about 800 nm, about 700 nm to about 750 nm, about 750 nm to about 2,000 nm, about 750 nm to about 1,500 nm, about 750 nm to about 1,000 nm, about 750 nm to about 950 nm, about 750 nm to about 900 nm, about 750 nm to about 850 nm,About 750 nm to about 800 nm, about 800 nm to about 2,000 nm, about 800 nm to about 1,500 nm, about 800 nm to about 1,000 nm, about 800 nm to about 950 nm, about 800 nm to about 900 nm, about 800 nm to about 850 nm, about 850 nm to about 2,000 nm, about 850 nm to about 1,500 nm, about 850 nm to about 1,000 nm, about 850 nm to about 950 nm, about 850 nm to about 900 nm, about 900 nm to about 2,000 nm, about 900 nm to about 1,500 nm, about 900 nm to about 1,000 nm, about 900 nm to about 950 nm, about It may be from about 950 nm to about 2,000 nm, from about 950 nm to about 1,500 nm, or from about 950 nm to about 1,000 nm.

[0029] In one embodiment of the present invention, the average thickness of the graphene oxide may be about 1 nm or more, about 5 nm or more, about 10 nm or more, about 20 nm or more, about 30 nm or more, about 40 nm or more, about 50 nm or more, about 60 nm or more, about 70 nm or more, about 80 nm or more, about 90 nm or more, about 100 nm or more, about 150 nm or more, about 200 nm or more, about 250 nm or more, or about 300 nm or more.

[0030] In one embodiment of the present invention, the average thickness of the graphene oxide may be about 1 nm or less, about 5 nm or less, about 10 nm or less, about 20 nm or less, about 30 nm or less, about 40 nm or less, about 50 nm or less, about 60 nm or less, about 70 nm or less, about 80 nm or less, about 90 nm or less, about 100 nm or less, about 150 nm or less, about 200 nm or less, about 250 nm or less, or about 300 nm or less.

[0031] In one embodiment of the present invention, the average thickness of the graphene oxide is about 1 nm to about 300 nm, about 1 nm to about 250 nm, about 1 nm to about 200 nm, about 1 nm to about 150 nm, about 1 nm to about 100 nm, about 1 nm to about 90 nm, about 1 nm to about 80 nm, about 1 nm to about 70 nm, about 1 nm to about 60 nm, about 1 nm to about 50 nm, about 1 nm to about 40 nm, about 1 nm to about 30 nm, about 1 nm to about 20 nm, about 1 nm to about 10 nm, about 1 nm to about 5 nm, about 5 nm to about 300 nm, about 5 nm to about 250 nm, about 5 nm to about 200 nm, about 5 nm to about 150 nm, about 5 nm to about 100 nm, about 5 nm to about 90 nm, about 5 nm to about 80 nm, about 5 nm to about 70 nm, about 5 nm to about 60 nm, about 5 nm to about 50 nm, about 5 nm to about 40 nm, about 5 nm to about 30 nm, about 5 nm to about 20 nm, about 5 nm to about 10 nm, about 10 nm to about 300 nm, about 10 nm to about 250 nm, about 10 nm to about 200 nm, about 10 nm to about 150 nm, about 10 nm to about 100 nm, about 10 nm to about 90 nm, about 10 nm to about 80 nm, about 10 nm to about 70 nm, about 10 nm to about 60 nm, about 10 nm to about 50 nm, about 10 nm to about 40 nm, about 10 nm to about 30 nm, about 10 nm to about 20 nm, about 30 nm to about 300 nm, about 30 nm to about 250 nm, about 30 nm to about 200 nm, about 30 nm to about 150 nm, about 30 nm to about 100 nm, about 30 nm to about 90 nm,About 30 nm to about 80 nm, about 30 nm to about 70 nm, about 30 nm to about 60 nm, about 30 nm to about 50 nm, about 30 nm to about 40 nm, about 50 nm to about 300 nm, about 50 nm to about 250 nm, about 50 nm to about 200 nm, about 50 nm to about 150 nm, about 50 nm to about 100 nm, about 50 nm to about 90 nm, about 50 nm to about 80 nm, about 50 nm to about 70 nm, about 50 nm to about 60 nm, about 70 nm to about 300 nm, about 70 nm to about 250 nm, about 70 nm to about 200 nm, about 70 nm to about 150 nm, about 70 nm to about 100 nm, about 70 nm about 90 nm, about 70 nm to about 80 nm, about 90 nm to about 300 nm, about 90 nm to about 250 nm, about 90 nm to about 200 nm, about 90 nm to about 150 nm, about 90 nm to about 100 nm, about 100 nm to about 300 nm, about 100 nm to about 250 nm, about 100 nm to about 200 nm, or about 100 nm to about 150 nm.

[0032] In one embodiment of the present invention, the graphene oxide may be functionalized with one or more functional groups selected from a quaternary ammonium salt, an alkyl group, an alkoxy group, a hydroxyl group, a carboxyl group, a carbonyl group, an amine group, a nitrile group, a thiol group, a sulfonate group, an aldehyde group, a peroxide group, an ether group, an epoxy group, and a ketone group.

[0033] In one embodiment of the present invention, the graphene oxide may be functionalized with a quaternary ammonium salt represented by the following chemical formula 1:

[0034] [Chemical Formula 1]

[0035] ;

[0036] In chemical formula 1,

[0037] R 1 and R 2 are, independently, unsubstituted or substituted, linear or branched C 1-10 Alkyl group, linear or branched C 2-10 Alkenyl group, linear or branched C 2-10 alkynyl group, or C 5-10 It is a cycloalkyl group,

[0038] X - is a halide ion,

[0039] n is an integer between 10,000 and 10,000,000.

[0040] In one embodiment of the present invention, n is about 10,000 to about 10,000,000, about 10,000 to about 9,000,000, about 10,000 to about 8,000,000, about 10,000 to about 7,000,000, about 10,000 to about 6,000,000, about 10,000 to about 5,000,000, about 10,000 to about 4,000,000, about 10,000 to about 3,000,000, about 10,000 to about 2,000,000, about 10,000 to about 1,000,000, about 10,000 to about 900,000, about It may be an integer of from about 10,000 to about 800,000, from about 10,000 to about 700,000, from about 10,000 to about 600,000, from about 10,000 to about 500,000, from about 10,000 to about 400,000, from about 10,000 to about 300,000, from about 10,000 to about 200,000, or from about 10,000 to about 100,000.

[0041] In one embodiment of the present invention, R 1 and R 2 If this is substituted, R 1 and R 2is a halogen group, a hydroxyl group, an amino group, a carboxyl group, a cyano group, a nitro group, a formyl group, and C 1-10 It may be substituted with one or more selected from alkyl groups.

[0042] In one embodiment of the present invention, X - can be a fluoride ion, a chloride ion, a bromide ion, or an iodide ion.

[0043] In one embodiment of the present invention, the quaternary ammonium salt may be selected from poly(diallyldimethylammonium) (poly(diallyldimethylammonium; PDDA) salt, poly(diallyldiethylammonium) salt, poly(diallyldipropylammonium) salt, poly(diallyldibutylammonium) salt, poly(diallyldipentylammonium) salt, and poly(diallyldihexylammonium) salt.

[0044] In one embodiment of the present invention, the graphene oxide may be functionalized with one or more compounds selected from PEG (polyethylene glycol), PSS (poly(styrene sulfonate)), PEI (polyetherimide), PEI (polyethylenimine), PAA (poly(allyl amine)), PNIPAM (poly(N-isopropyl acrylamide), CS (Chitosan), PMA (poly(methacrylic acid)), PVS (poly(vinyl sulfate)), PAA (poly(amic acid)), PAH (poly(allylamine hydrochloride)), PVAc (polyvinyl acetate), PVP (polyvinylpyrrolidone), PVA (polyvinyl alcohol), PMMA (poly(methyl methacrylate)), PC (polycarbonate), and PMIA (poly(m-phenylene isophthalamide)), but may not be limited thereto.

[0045] In one embodiment of the present invention, the concentration of the graphene oxide may be from about 1 ppb to about 10,000,000 ppb, but may not be limited thereto.

[0046] In one embodiment of the present invention, the composition may adsorb a hormone. In one embodiment of the present invention, the hormone may be at least one selected from pituitary hormones, thyroid hormones, parathyroid hormones, thymus hormones, adrenal hormones, testicular hormones, pancreatic hormones, ovarian hormones, placental hormones, and follicle hormones.

[0047] In one embodiment of the present invention, the composition may adsorb a sex hormone. In one embodiment of the present invention, the sex hormone may be a steroid hormone, and may be at least one selected from androgen, estrogen, progesterone, and derivatives thereof.

[0048] In one embodiment of the present invention, the composition may adsorb androgens. In one embodiment of the present invention, the androgens may include at least one selected from testosterone, dihydrotestosterone, androgens, androstenedione, and dehydroepiandrosterone, but may not be limited thereto.

[0049] In one embodiment of the present invention, the composition may be a cosmetic composition, a quasi-drug composition, or a pharmaceutical composition, but may not be limited thereto.

[0050] In one embodiment of the present invention, the hormone adsorption composition comprises graphene oxide having an average diameter of about 100 nm or more, and may have superior hormone adsorption ability compared to graphene oxide having an average diameter of less than 100 nm.

[0051] The second aspect of the present invention provides a cosmetic composition for hormone absorption, comprising graphene oxide.

[0052] Detailed explanations of parts that overlap with the first aspect of the present application have been omitted, but the contents described in the first aspect of the present application may be equally applied even if the explanation is omitted in the second aspect of the present application.

[0053] In one embodiment of the present invention, the cosmetic composition is a hair tonic, a hair conditioner, a hair essence, a hair lotion, a hair nutrition lotion, a hair shampoo, a hair rinse, a hair treatment, a hair cream, a hair nutrition cream, a hair moisture cream, a hair massage cream, a hair wax, a hair aerosol, a hair pack, a hair nutrition pack, a hair soap, a hair cleansing foam, a hair oil, a hair drying agent, a hair preservation agent, a hair dye, a hair waving agent, a hair bleaching agent, a hair gel, a hair glaze, a hair dressing agent, a hair lacquer, a hair moisturizer, a hair mousse, a hair spray, an eyebrow hair growth agent, an eyelash hair growth agent, an eyelash nutrition agent, a pet shampoo or rinse, a toner, a nutrition cream, a massage cream, an eye cream, an eye essence, an essence, a cleansing cream, a cleansing lotion, a cleansing foam, a cleansing water, a pack, a powder, a body lotion, a body cream, a body essence, It may be in the form of a body spray or body cleanser, but may not be limited thereto.

[0054] In one embodiment of the present invention, the cosmetic composition may further include other components other than the graphene oxide depending on the intended use, etc. For example, the cosmetic composition may further include components and / or functional additives generally included in cosmetic compositions. The components generally included in cosmetic compositions may include, but are not limited to, moisturizers, emollients, surfactants, ultraviolet absorbers, preservatives, bactericides, antioxidants, pH adjusters, organic and inorganic pigments, fragrances, or cooling agents. The functional additives may include, but are not limited to, water-soluble vitamins, oil-soluble vitamins, polymeric peptides, or polymeric polysaccharides.

[0055] The third aspect of the present invention provides a pharmaceutical composition for hormone absorption, comprising graphene oxide.

[0056] Detailed descriptions of overlapping parts with the first and second aspects of the present application have been omitted, but the contents described for the first and second aspects of the present application may be equally applied even if the description is omitted in the third aspect of the present application.

[0057] Typically, “over-the-counter drugs” refer to products used for the purpose of treating diseases or alleviating or preventing symptoms, while “cosmetics” refer to products used for the purpose of maintaining or promoting the health of the skin or hair for the purpose of cleansing and beautifying the human body.

[0058] The hormone-absorbing composition of the present invention may be classified as a quasi-drug composition if it contains graphene oxide in a high content above a certain level and is used for the purpose of treating a physical disease or alleviating or preventing symptoms. If it contains graphene oxide in a lower content than the quasi-drug composition and has a mild pharmaceutical effect and is used for the purpose of maintaining or promoting physical health, it may be classified as a cosmetic composition. Accordingly, the quasi-drug composition of the present invention may have the same formulation as the cosmetic composition, and may exhibit a pharmaceutical effect by adjusting the content range of the graphene oxide.

[0059] In one embodiment of the present invention, the above-mentioned pharmaceutical composition is a hair tonic, a hair conditioner, a hair essence, a hair lotion, a hair nutrition lotion, a hair shampoo, a hair rinse, a hair treatment, a hair cream, a hair nutrition cream, a hair moisture cream, a hair massage cream, a hair wax, a hair aerosol, a hair pack, a hair nutrition pack, a hair soap, a hair cleansing foam, a hair oil, a hair drying agent, a hair preservation agent, a hair dye, a hair waving agent, a hair bleaching agent, a hair gel, a hair glaze, a hair dressing agent, a hair lacquer, a hair moisturizer, a hair mousse, a hair spray, an eyebrow hair growth agent, an eyelash hair growth agent, an eyelash nutrition agent, a pet shampoo or rinse, a toner, a nutrition cream, a massage cream, an eye cream, an eye essence, an essence, a cleansing cream, a cleansing lotion, a cleansing foam, a cleansing water, a pack, a powder, a body lotion, a body cream, a body essence, It may be in the form of a body spray or body cleanser, but may not be limited thereto.

[0060] In one embodiment of the present invention, the above-mentioned pharmaceutical composition may additionally include other pharmaceutical ingredients other than the above-mentioned graphene oxide, depending on the purpose of use, etc.

[0061] In one embodiment of the present invention, the content of the graphene oxide of the above pharmaceutical composition can be appropriately selected depending on the purpose of use (prevention, health or therapeutic treatment).

[0062] The fourth aspect of the present invention provides a pharmaceutical composition for hormone absorption, comprising graphene oxide.

[0063] Detailed descriptions of parts overlapping with aspects 1 to 3 of the present application have been omitted, but the contents described for aspects 1 to 3 of the present application may be equally applied even if the description is omitted in aspect 4 of the present application.

[0064] In one embodiment of the present invention, the pharmaceutical composition may be administered parenterally. The parenteral administration method may include, but is not limited to, intramuscular administration, transdermal administration, or subcutaneous administration.

[0065] In one embodiment of the present invention, the pharmaceutical composition may be administered by applying it to the diseased area or by injecting it, but may not be limited thereto.

[0066] In one embodiment of the present invention, the pharmaceutical composition may be formulated into a pharmaceutical formulation conventional in the art. Specifically, the pharmaceutical composition may be formulated as an injectable solution for intramuscular, transdermal, or subcutaneous administration; or as a topical skin preparation for topical application.

[0067] In one embodiment of the present invention, the pharmaceutical composition may be in the form of an injection, cream, ointment, paste, gel, patch, jelly, serum, powder, aerosol spray, non-aerosol spray, foam, lotion, solution or suspension, but may not be limited thereto.

[0068] In one embodiment of the present invention, the pharmaceutical composition may further comprise a sterilized aqueous solution, non-aqueous solvent, suspension, emulsion, freeze-dried preparation, or external preparation for formulation into the dosage form. Specifically, if the dosage form is an injection, it may further comprise a stabilizer, a buffer, and / or water. If the dosage form is a paste, cream, or gel, it may further comprise animal fiber, plant fiber, wax, paraffin, starch, tragacanth, cellulose derivatives, polyethylene glycol, silicone, bentonite, silica, talc, or zinc oxide as a carrier component. If the dosage form is a powder or spray, it may further comprise lactose, talc, silica, aluminum hydroxide, calcium silicate, or polyamide powder as a carrier component. If the dosage form is a spray, it may further comprise a propellant such as chlorofluorohydrocarbon, propane / butane, or dimethyl ether.

[0069] In one embodiment of the present invention, the pharmaceutical composition may further include another therapeutic agent suitable for treating the desired disease.

[0070] Hereinafter, the present invention will be described in more detail using examples. However, the following examples are provided only to help understand the present invention, and the contents of the present invention are not limited to the following examples.

[0071] [Example]

[0072] Example 1: Preparation of graphene oxide (GO)

[0073] 1) Production of graphene oxide with various diameters

[0074] Graphene oxide was produced using the Hummer's method. Graphite was sufficiently stirred in an H2SO4 solution at room temperature, and then KMnO4 was added to the solution. After that, H2O2 was additionally added to the solution, and the oxidation reaction of graphite was induced to form graphene oxide. After several purification processes, graphene oxide was obtained. Next, the graphene oxide was dispersed in water to obtain an aqueous graphene oxide dispersion. At this time, the graphene oxide particles can be decomposed into nanometer diameters by ultrasonic treatment, and particles with a diameter of several nanometers (1 nm to 10 nm) can be obtained. The graphene oxide classified into various diameter sizes is used for laser diffraction (Mie scattering method). In the Mie scattering method, when light collides with a particle, scattering (diffraction) occurs, and the detector can obtain different electric signals depending on the angle and intensity of the scattered light. At this time, based on the Mie theory, the size of the sample (test product) is determined from each different electric signal. A distribution can be obtained. From this, the size (average diameter) of each sample was adjusted.

[0075] 2) Preparation of PDDA (Poly(diallyldimethylammonium) salt-functionalized graphene oxide

[0076] 1) 30 mg of dried graphene oxide prepared in step 1 was dispersed in 30 mL of ultrapure water (1 mg / mL, 0.1 wt%) and sonicated to prepare an aqueous graphene oxide dispersion. Then, a 35 wt% poly(diallyldimethylammonium chloride) solution (Sigma Aldrich) was added to the aqueous graphene oxide dispersion and mixed at room temperature for 2 hours using a magnetic stirrer. At this time, the amount of PDDA salt solution was adjusted to 30 μL to 600 μL. Thereafter, a centrifuge was used to remove the PDDA aqueous dispersion in the form of a transparent liquid that was separated without reacting with the graphene oxide.

[0077] Experimental Example 1: Evaluation of Hormone Adsorption Capacity of Graphene Oxide

[0078] 1) Test method

[0079] To evaluate the testosterone (TST) adsorption capacity of graphene oxide, 1% TST and the test substance were reacted at different concentrations (1,000 ppb, 10,000 ppb, 100,000 ppb, and 1,000,000 ppb) at room temperature for 24 hours. After centrifugation at 13,000 rpm for 30 minutes, only the supernatant was collected. The collected supernatant was diluted 100-fold with ethyl alcohol (99.9%) and used for measuring the TST content. The analysis was performed using an Agilent 1260 series LC, and an Agilent poroshell HPH-C18 (4 μm, 4.6 × 150 mm) column under the following conditions: column temperature 55°C, sample injection amount 5 μL, and flow rate 0.5 mL / min. The absorbance was measured three times at a wavelength of 240 nm with the mobile phase composition according to the analysis time as follows. TST standard solutions with concentrations of 1, 10, 50, 100, and 200 ppm were measured to create a calibration curve for each TST, which was then used to calculate the TST content.

[0080] Min0.1% Formic acid in water (%)Acetonitrile (%)040604595659574060104060

[0081] 2) Results

[0082] The testosterone hormone adsorption capacity of PDDA-functionalized graphene oxide (GO-PDDA 110 nm) with an average diameter of 110 nm was evaluated. As a result of the evaluation, as described with reference to Fig. 1 and Table 2, it was confirmed that GO-PDDA 110 nm significantly reduced the TST concentration compared to 1% TST at all concentrations. In addition, it was confirmed that the TST adsorption capacity tended to increase as the concentration of GO-PDDA 110 nm increased.

[0083] TST concentration (%) Control 0 TST 1% 100 GO-PDDA 110 nm (ppb) 1,000 9 3.894 ± 1.19 4 10,000 8 8.603 ± 1.21 7 100,000 8 9.642 ± 0.57 2 1,000,000 8 6.697 ± 0.53 6

[0084] The above description of the present invention is for illustrative purposes only, and those skilled in the art will readily appreciate that the present invention can be readily modified into other specific forms without altering the technical spirit or essential characteristics of the present invention. Therefore, the embodiments described above should be understood as illustrative in all respects and not restrictive. For example, each component described as a single entity may be implemented in a distributed manner, and similarly, components described as distributed may be implemented in a combined manner.

[0085] The scope of the present invention is indicated by the claims described below rather than the detailed description above, and all changes or modifications derived from the meaning and scope of the claims and their equivalent concepts should be interpreted as being included in the scope of the present invention.

Claims

1. A composition for hormone absorption, comprising graphene oxide.

2. In paragraph 1, A composition for hormone absorption, wherein the average diameter of the above graphene oxide is 1 nm to 2,000 nm.

3. In paragraph 1, A composition for hormone absorption, wherein the average diameter of the above graphene oxide is 100 nm to 1,000 nm.

4. In paragraph 1, A composition for hormone absorption, wherein the average thickness of the above graphene oxide is 1 nm to 300 nm.

5. In paragraph 1, A composition for hormone absorption, wherein the above graphene oxide is functionalized with one or more functional groups selected from a quaternary ammonium salt, an alkyl group, an alkoxy group, a hydroxyl group, a carboxyl group, a carbonyl group, an amine group, a nitrile group, a thiol group, a sulfonate group, an aldehyde group, a peroxide group, an ether group, an epoxy group, and a ketone group.

6. In paragraph 1, A composition for hormone absorption, wherein the above graphene oxide is functionalized with one or more compounds selected from PEG (polyethylene glycol), PSS (poly(styrene sulfonate)), PEI (polyetherimide), PEI (polyethylenimine), PAA (poly(allyl amine)), PNIPAM (poly(N-isopropyl acrylamide), CS (Chitosan), PMA (poly(methacrylic acid)), PVS (poly(vinyl sulfate)), PAA (poly(amic acid)), PAH (poly(allylamine hydrochloride)), PVAc (polyvinyl acetate), PVP (polyvinylpyrrolidone), PVA (polyvinyl alcohol), PMMA (poly(methyl methacrylate)), PC (polycarbonate), and PMIA (Poly(m-phenylene isophthalamide)).

7. In paragraph 1, A composition for hormone absorption, wherein the above graphene oxide is functionalized with a quaternary ammonium salt represented by the following chemical formula 1: [Chemical Formula 1] ; In chemical formula 1, R 1 and R 2 are, independently, unsubstituted or substituted, linear or branched C 1-10 Alkyl group, linear or branched C 2-10 Alkenyl group, linear or branched C 2-10 alkynyl group, or C 5-10 It is a cycloalkyl group, X - is a halide ion, n is an integer between 10,000 and 10,000,000.

8. In paragraph 5, A composition for hormone absorption, wherein the quaternary ammonium salt is selected from poly(diallyldimethylammonium) (poly(diallyldimethylammonium; PDDA) salt, poly(diallyldiethylammonium) salt, poly(diallyldipropylammonium) salt, poly(diallyldibutylammonium) salt, poly(diallyldipentylammonium) salt, and poly(diallyldihexylammonium) salt.

9. In paragraph 1, A composition for hormone absorption, wherein the concentration of the above graphene oxide is 1 ppb to 10,000,000 ppb.

10. In paragraph 1, The above composition is a hormone-absorbing composition that absorbs male hormones.

11. In paragraph 1, A hormone absorption composition, wherein the composition is a cosmetic composition, a pharmaceutical composition, or a pharmaceutical composition.

12. A cosmetic composition for hormone absorption, comprising graphene oxide.

13. A pharmaceutical composition for hormone absorption, comprising graphene oxide.

14. A pharmaceutical composition for hormone absorption, comprising graphene oxide.

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