Split double-chamber balanced air pressure liquid medicine transfer device

Abstract

A split double-chamber balanced air pressure liquid medicine transfer device, comprising an assembly I and an assembly II, wherein the assembly I comprises a first syringe (1), a first needle hub (2), and a dispensing needle assembly (3); and the assembly II comprises a second syringe (4), a second needle hub (5), and a puncture needle (6) fixedly connected to the second needle hub (5). When the assembly I and the assembly II are fixedly connected, the puncture needle (6) of the assembly II pierces a sealing plug (25) in a vent (24) of the assembly I to be in communication with a second channel (22) in the first needle hub (2). The liquid medicine transfer device can be conveniently applied to a push injection device for quantitative liquid medicine transfer while retaining the characteristics of airtightness and air pressure balance.

Description

A split double-chamber pressure-balanced liquid medicine transfer device

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS

[0002] This application claims priority to the Chinese patent application filed on August 31, 2023, with application number 202311115785.2 and entitled “A Split-Type Dual-Chamber Air Pressure Balanced Liquid Transfer Device”. Technical Field

[0003] The invention relates to the field of medical dispensing and liquid transfer devices, in particular to a split double-chamber pressure-balanced liquid medicine transfer device. Background Art

[0004] Dangerous drugs, such as chemotherapy drugs, pose a significant health risk to the medical staff involved in their long-term preparation and transportation. Some medical institutions have built cleanrooms, bio-cabinets, and other facilities to mitigate the risk of drug leaks, despite significant investment. However, these facilities have proven ineffective in practical application.

[0005] Chinese patent publication number CN115607444B (CN202211220305.4) discloses a closed-type drug liquid transfer device and system with dual-chamber internal circulation. The dispensing device incorporates a dual-chamber syringe, one for liquid infusion and the other for air pressure balance. This effectively ensures the tightness of the dispensing process and reduces the risk of leakage.

[0006] Another application of a drug liquid transfer device (i.e., a dispenser) is to serve as a drug supply source to achieve quantitative drug supply in a drug supply device. Generally speaking, after the drug is prepared, this type of dispensing device needs to be installed on a push injection device that can control the infusion volume / infusion speed (such as Medfusion's WZS-50F6 push injection device, or MEDCAPTAIN's SYS-52 push injection device). The push injection device can fix the syringe barrel of the dispenser and push the piston rod to move at a preset speed, thereby achieving quantitative infusion. If a dual-chamber syringe is directly installed on the push injection device, it will push both piston rods at the same time, making the push injection device inoperable, or occupying space and affecting the normal operation of other accessories.

[0007] Summary of the Invention

[0008] To address the problem that new medication dispensers are incompatible with existing push-in injection devices, the present invention provides a split, dual-chamber, pressure-balanced medication transfer device. This improved medication transfer device, while retaining its airtightness and pressure balance, can be conveniently adapted for push-in injection devices to deliver a fixed amount of medication.

[0009] In order to achieve the above-mentioned purpose, the present invention adopts the following technical solutions.

[0010] A split double-chamber air pressure balanced liquid medicine transfer device comprises component I and component II, wherein: component I comprises a first syringe, a first needle seat and a dispensing needle assembly, wherein the first needle seat is connected and fixed to the first syringe through a joint on the first syringe, and the dispensing needle assembly is fixedly connected to the first needle seat; a first channel and a second channel are provided inside the first needle seat, an air window is provided on the side, and a cavity for being connected and fixed to the joint on the first syringe is provided at the end; the end of the first channel is connected to the cavity, and the end of the second channel is connected to the air window; a sealing plug is provided in the air window; the dispensing needle assembly comprises an infusion channel and an exhaust channel, wherein the infusion channel is connected to the first channel, and the exhaust channel is connected to the second channel; component II comprises a second syringe, a second needle seat and a puncture needle fixedly connected to the second needle seat; when components I and II are fixedly connected, the puncture needle of component II pierces the sealing plug in the air window of component I and is connected to the second channel in the first needle seat; when components I and II are separated, the sealing plug in the air window makes the air window in a sealed state.

[0011] In the present invention, unless otherwise specified, when describing the component structure, the front end refers to the end to which the needle tip of the dispensing needle and / or puncture needle points, and the rear end (or tip) refers to the other end opposite thereto.

[0012] The structure of a syringe is readily understood and understood by those skilled in the art. It typically comprises a syringe barrel and a piston rod that slides back and forth within the barrel along its inner cavity. Specifically, a first syringe comprises a first syringe barrel and a first piston rod that slides back and forth within the barrel along its inner cavity; a second syringe comprises a second syringe barrel and a second piston rod that slides back and forth within the barrel along its inner cavity.

[0013] Preferably, when components I and II are fixedly connected, the first syringe and the second syringe are fixedly connected in a side-by-side and unidirectional manner. Further preferably, a snap-fit ​​structure is provided on the outer wall of at least one of the first syringe and the second syringe, so that the first syringe and the second syringe are detachably fixed to each other when they are arranged side by side and in the same direction. More preferably, at least one of the first syringe and the second syringe is provided with a support portion on the barrel wall, and the end structure of the support portion matches the outer side wall of the opposite syringe, so that the first syringe and the second syringe are mutually supported by the support portion when they are arranged side by side and in the same direction.

[0014] In the split dual-chamber pressure-balanced liquid medicine transfer device of the present invention, component I includes a first syringe, a first needle seat and a dispensing needle assembly.

[0015] Inside the first needle hub, the end of the second channel connects to the air window. When the puncture needle of component II pierces the sealing plug inside the air window of component I, the second channel connects to the second syringe via the puncture needle tube. When components I and II are separated, the sealing plug inside the air window seals the air window, isolating it from the outside world.

[0016] Preferably, a stop-go module for controlling the passage or isolation of the second channel is provided in the second channel of the first needle seat, so as to further ensure the sealing of the second channel relative to the outside world. As an embodiment, the stop-go module is a rotatable stop-go valve, and a through hole is provided in the valve; the stop-go valve is rotated so that the through hole and the second channel are aligned or misaligned, which can conveniently realize the passage or isolation of the channels on both sides. As another embodiment, the stop-go module is a control valve, which includes a slider, and a slide groove which is provided through the first needle seat and passes through the second channel radially, the slider is slidably provided in the slide groove, and a through hole is provided in the slider; when the slider slides to a preset position, the two ends of the through hole are respectively docked with the second channel, and when the slider slides out of the preset position, the outer side surface of the slider isolates the second channel.

[0017] As a preferred embodiment, the first needle seat is radially provided with a raised portion on one side close to the second channel, and the air window is provided at the end of the raised portion. Further preferably, the length of the raised portion exceeds the radius of the first syringe.

[0018] The sealing plug is made of an elastic material, preferably any one of rubber, silicone, and synthetic rubber. Applicable elastic materials should comply with relevant standards for medical materials, which is easy to know and determine for those skilled in the art.

[0019] The dispensing needle assembly includes an infusion channel and an exhaust channel, wherein the infusion channel is communicated with the first channel, and the exhaust channel is communicated with the second channel.

[0020] In one embodiment, the dispensing needle assembly comprises a first needle tube and a second needle tube, both arranged in parallel and fixedly connected to a first needle hub with their rear ends embedded therein. The inner lumen of the first needle tube forms an infusion channel, with its rear end communicating with the first channel; the inner lumen of the second needle tube forms an exhaust channel, with its rear end communicating with the second channel. Particularly preferably, the first needle tube, the first channel, and the first syringe are coaxially arranged.

[0021] In another embodiment, the dispensing needle assembly has a double-layered columnar structure, comprising an inner column channel and a side ring channel, one of which serves as an infusion channel and the other as an exhaust channel. Preferably, the dispensing needle assembly comprises an inner needle tube and an outer needle tube, with the inner needle tube inserted within the outer needle tube and extending beyond the outer needle tube at both ends. In this case, the inner column channel is formed by the inner cavity of the inner needle tube, and the side ring channel is formed by the cavity between the outer and inner needle tubes. The inner and outer needle tubes can be independent of each other or integrally formed and fixedly connected. In the latter case, the front end of the outer needle tube is preferably sealed and fixedly connected to the front side wall of the inner needle tube. Further preferably, the front end of the inner needle tube is configured as an oblique opening, or the front end of the inner needle tube is pointed and provided with a side opening, while the front side wall of the outer needle tube is provided with a side opening. Such an opening design not only facilitates the dispensing needle's insertion into the container but also reduces interference between the inner column channel and the side ring channel. In one specific embodiment, a double-layered cylindrical dispensing needle assembly, a first channel, and a first syringe are coaxially arranged. The inner column channel formed by the inner lumen of the inner needle tube serves as the infusion channel, and the side ring channel formed by the cavity between the outer and inner needle tubes serves as the exhaust channel. In another specific embodiment, in a double-layered cylindrical dispensing needle assembly, the inner column channel formed by the inner lumen of the inner needle tube serves as the exhaust channel, and the side ring channel formed by the cavity between the outer and inner needle tubes serves as the infusion channel.

[0022] Preferably, component I further comprises a needle sealing assembly, which comprises a first sleeve, a first sealing member and a first elastic member which are coaxially arranged with the first needle seat; wherein: the first sleeve is a hollow cylindrical structure with front and rear openings, and is axially movably sleeved on the front end of the first needle seat; the first sealing member is made of elastic material and is fixedly arranged in the front end cylindrical body of the first sleeve; a hole for the needle tube to pass through is provided in the first sealing member, and the inner diameter of the hole is smaller than the outer diameter of the needle tube; the first elastic member is arranged between the first sealing member and the first needle seat, and relies on the needle seat to provide axial elastic support for the first sealing member at the front end; in a non-pressurized state, the first elastic member extends axially, the first sleeve shields the needle tube inside the sleeve, and under the elastic force of the elastic material, the first sealing member tightly wraps the front end of the needle tube, sealing the front end channel openings of the infusion channel and the exhaust channel; in a pressurized state, the first elastic member is axially compressed, and the front end of the needle tube, including the front end channel openings of the infusion channel and the exhaust channel, can pass through the first sleeve through the hole of the first sealing member.

[0023] The needle seal assembly not only provides puncture protection but also ensures a fully sealed state during the preparation and transfer of the drug solution, preventing the risk of drug leakage from the front channel. Components with similar structures and functions have been reported in the applicant's prior patents, such as CN115607444B, which are incorporated herein in their entirety.

[0024] As a preferred embodiment of the present invention, the needle sealing assembly includes a coaxially arranged first sleeve, a first sealing member, a first elastic member and an inner sleeve, wherein: the front end of the first sleeve has a smaller inner diameter, forming a composite cylindrical structure consisting of a first barrel section with a smaller inner diameter and a second barrel section with a larger inner diameter; the first sealing member is designed as a structure with an inverted T-shaped cross-section, the front diameter corresponds to the inner diameter of the first barrel section, and the rear diameter corresponds to the inner diameter of the second barrel section, so that the first sealing member can fill at least part of the inner cavity of the second barrel section while completely filling the inner cavity of the first barrel section; the inner diameter of the inner sleeve corresponds to the outer diameter of the first needle seat, and the outer diameter of the inner sleeve corresponds to the inner diameter of the second barrel section of the first sleeve, its front end face is closed and a through hole for the needle tube to pass through is provided on the end face; the inner sleeve is fixedly connected to the second barrel section of the first sleeve, and the front end face abuts the rear end face of the first sealing member; the first elastic member is arranged in the inner sleeve, and its two ends abut the front end inner surface of the inner sleeve and the front end face of the first needle seat respectively.

[0025] By improving the structure of the first sleeve and the first sealing member and adding an inner sleeve, the first sealing member is limited and fixed, and the front and rear ends of the first elastic member are both in contact with the hard material, making the overall structure and performance more stable. Further preferably, the outer wall of the inner sleeve is provided with a buckle, and the second barrel section of the first sleeve is provided with a corresponding clamping hole. When the inner sleeve is inserted into the first sleeve, the buckle and the clamping hole cooperate to achieve a fixed connection between the first sleeve and the inner sleeve. Preferably, the rear port of the inner sleeve is provided with an annular boss in a radially outward manner. When the front end face of the inner sleeve abuts the rear end face of the first sealing member, the annular boss at the rear end is exposed to the first sleeve and abuts against the rear end of the first sleeve.

[0026] It is easy to understand that during the use of the liquid medicine transfer device described in the present invention, although the needle seal assembly will move axially as the first elastic member expands and contracts, it always remains connected to the first needle seat. As a preferred embodiment, a snap-fit ​​structure is provided on the front inner surface of the inner sleeve and the front end surface of the first needle seat to achieve a fixed connection with the first elastic member. As another preferred embodiment, the side of the first needle seat is provided with an L-shaped groove consisting of an axial groove and a transverse groove (perpendicular to the axial groove), and a slide is provided radially inward at the rear end of the inner sleeve. The slide is embedded in the L-shaped groove and can slide along the groove. By designing the position of the slide and the L-shaped groove, the range of motion of the needle seal assembly relative to the first needle seat can be flexibly adjusted and limited. As the slide slides backward along the axial groove, the first elastic member is compressed and the needle tube passes through the first sealing member. When the set degree is reached, the slide is rotated along the transverse groove to limit the axial movement of the needle seal assembly, thereby achieving a limited and fixed effect.

[0027] The first sealing member is made of an elastic material, preferably any one of rubber, silicone, and synthetic rubber. Suitable elastic materials should comply with relevant standards for medical materials, which is readily known and determined by those skilled in the art. In a preferred embodiment, the front end of the first sealing member protrudes beyond the front end of the first sleeve. This allows the elastic sealing member to fit over the container's plastic opening during preparation and transfer of liquid medicine, effectively sealing the container opening.

[0028] The first elastic member can be an elastic folding tube, a spring, etc., preferably a spring.

[0029] It is easy to understand that, for the purpose of achieving better connection with infusion tubes, medicine bottles, injection devices, etc., the front end of the first sleeve is preferably provided with a fixed connection structure (such as a rotating snap structure, etc.) adapted to the pipette connector, so as to facilitate fixed connection with the connector. The pipette connector is easy to understand for those skilled in the art. There are a large number of reports of similar structures in the prior art. Its function is mainly to achieve an auxiliary fixed connection between the drug liquid transferor and the infusion tube interface, the bottle mouth of the medicine bottle or the liquid inlet of other equipment; preferably, the pipette connector is provided with a sealing member (such as a rubber stopper) that can be pierced by a needle at one end corresponding to the drug liquid transferor, so as to better play the sealing function during the infusion or drug liquid transfer process.

[0030] Component II includes a second syringe, a second needle holder, and a puncture needle fixedly connected to the second needle holder. When Components I and II are fixedly connected, the puncture needle of Component II pierces the sealing plug in the air window of Component I and communicates with the second channel in the first needle holder.

[0031] It is easy to understand that the structural arrangement of the second needle holder and puncture needle in component II should correspond to the structural arrangement of the air window in component I. Preferably, when the first needle holder is provided with a radially arranged protrusion on a side close to the second passage, and the air window is provided at the end of the protrusion, the second needle holder and puncture needle in component II are arranged perpendicular to the second syringe. When the first and second syringes are fixedly connected side by side and in the same direction, the puncture needle transversely pierces the sealing plug and communicates with the second passage in the first needle holder.

[0032] In order to achieve better system sealing, preferably, component II also includes a puncture needle sealing component, which includes a second sleeve, a second sealing member and a second elastic member coaxially arranged with the puncture needle; wherein the second sleeve is a hollow cylindrical structure with an open front end and a rear end fixedly connected to the second needle seat; the second sealing member is made of elastic material and is fixedly arranged in the front end cylinder of the second sleeve; the second sealing member is provided with a channel for the puncture needle to pass through, and the inner diameter of the channel is smaller than the outer diameter of the puncture needle; the second elastic member is arranged between the second sealing member and the second needle seat, and relying on the needle seat, the second elastic member provides axial elastic support for the second sealing member at the front end; in the non-pressurized state, the second elastic member extends axially, and the second sleeve shields the puncture needle inside the sleeve, and under the elastic force of the elastic material, the second sealing member tightly wraps the front end of the puncture needle and seals the puncture needle opening inside; in the pressurized state, the second sealing member slides toward the rear end, the second elastic member is axially compressed, and the front end of the puncture needle passes out of the second sealing member.

[0033] Further preferably, the puncture needle sealing assembly also includes a sliding sleeve coaxially arranged with the puncture needle. The sliding sleeve is a hollow cylindrical structure with front and rear openings, disposed within the second sleeve. Its outer diameter matches the inner diameter of the second sleeve and can slide axially forward and backward within the second sleeve. The second sealing member is filled within the sliding sleeve. Even more preferably, the sliding sleeve is designed as a composite cylindrical structure consisting of a front cylindrical section with a larger inner diameter and a rear cylindrical section with a smaller inner diameter. Accordingly, the second sealing member is designed with a T-shaped cross-section, so that the second sealing member can completely fill the inner cavity of the sliding sleeve.

[0034] In order to prevent the second sealing member or the sliding sleeve filled with the second sealing member from moving outside the second sleeve, a limiting structure, such as a radially inward boss, is preferably provided at the front end of the second sleeve.

[0035] The second sealing member is made of an elastic material, preferably any one of rubber, silicone, and synthetic rubber. Suitable elastic materials should comply with relevant standards for medical materials, which is readily known and determined by those skilled in the art. The second elastic member can be an elastic folding tube, a spring, or the like, preferably a spring.

[0036] As a preferred embodiment of the liquid medicine transfer device described in the present invention, the first needle holder in component I is radially provided with a raised portion on one side close to the second channel, and an air window is provided at the end of the raised portion; the second needle holder, puncture needle and puncture needle sealing assembly in component II are arranged perpendicular to the second syringe; when the first syringe and the second syringe are fixedly connected in a side-by-side and unidirectional manner, the air window with a sealing plug inside is inserted into the second sleeve and pushes the second sealing member or the sliding sleeve filled with the second sealing member to slide toward the rear end, the second elastic member is axially compressed, and the front end of the puncture needle passes through the second sealing member and pierces the sealing plug, thereby connecting with the second channel in the first needle holder. Further preferably, a fixed buckle structure is provided at the front end of the second sleeve, and a fixed buckle groove that cooperates with the fixed buckle structure is provided on the raised portion of the first needle holder; when components I and II are fixedly connected, the fixed buckle structure and the fixed buckle groove are fixed to each other.

[0037] The drug liquid transfer device of the present invention has the characteristics of dual-chamber internal circulation. After component I and component II are fixed and connected in a closed manner, the infusion channel, the first channel, the cavity of the first needle seat and the first syringe are connected in sequence from front to back to form a closed passage I; the exhaust channel, the second channel, the puncture needle tube and the second syringe are connected in sequence from front to back to form a closed passage II. The closed passages I and II are independent of each other. During the preparation and transfer of the drug liquid, the closed passage I is used to transmit the drug liquid, and the closed passage II plays the role of transmitting gas and balancing air pressure. The drug liquid transfer device can be used to prepare mixed drugs, transport the prepared drug liquid to an infusion bottle, an indwelling needle or an injection device, etc. Based on a full understanding of the structure of the above-mentioned drug liquid transfer device of the present invention, it is easy for a person skilled in the art to determine how to use it to prepare and transfer the drug liquid. For example, the applicant's prior patent CN115607444B can be referred to, which is incorporated herein in its entirety.

[0038] Correspondingly, the present invention also relates to the use of the drug liquid transfer device in quantitative infusion; and a quantitative infusion device comprising the drug liquid transfer device.

[0039] It is easy to understand that, similar to the closed liquid medicine transferor with dual-chamber internal circulation in CN115607444B, the liquid medicine transferor of the present invention also has the following excellent effects: (1) The structural design is sophisticated, and each component is a component that is easy to mass produce and assemble, without the need to use relatively complex components and special equipment. (2) The product has stable structure and performance, low cost but high yield, and is easy to use. (3) During the drug preparation and transfer process, the internal and external air pressures of the liquid medicine transfer system are completely balanced. (4) Fully enclosed drug preparation and transfer can be achieved, minimizing the risk of drug leakage, and the sealing effect is very excellent.

[0040] Not only that, the present invention can also solve the problem that the new dual-chamber dispenser cannot be used with existing injection equipment. The biggest improvement is that the drug liquid transferor of the present invention is designed to be split. After the user prepares the drug liquid (the drug liquid is located in the first syringe), he can easily separate component I and component II. At this time, the sealing plug re-seals the second channel, and component I can be very conveniently installed on the injection equipment to transfer a quantitative amount of drug liquid. BRIEF DESCRIPTION OF THE DRAWINGS

[0041] FIG1 is a schematic cross-sectional view of the liquid medicine transfer device of Example 1 in a split state;

[0042] FIG2 is a schematic cross-sectional view of the assembled liquid medicine transfer device of Example 1;

[0043] FIG3 is a schematic cross-sectional view of the assembled liquid medicine transfer device of Example 2;

[0044] FIG4 is a schematic diagram of the use state of component 1 of the liquid medicine transfer device of Example 2 connected to a chemotherapy pump;

[0045] FIG5 is a schematic cross-sectional view of the assembled liquid medicine transfer device of Example 3;

[0046] Figure 6a is a physical picture of the sample in the assembled state;

[0047] Figure 6b is a physical picture of the sample in a split state;

[0048] FIG6c is a physical picture of samples equipped with various connectors;

[0049] FIG7 is a schematic diagram of the use of component 1 in the liquid medicine transfer device of Example 3 on a single-channel quantitative injection device;

[0050] FIG8 is a schematic cross-sectional view of the drug liquid transfer device of Example 4 in a split state.

[0051] Figure numerals: first syringe 1, first syringe 11, first piston rod 12, connector 13, first needle seat 2, first channel 21, second channel 22, protrusion 23, air window 24, sealing plug 25, on-off valve 26, fixed card slot 27, cavity 28, dispensing needle assembly 3, first needle tube 31, second needle tube 32, second syringe 4, second syringe 41, second piston rod 42, snap structure 43, support portion 44, second needle seat 5, puncture needle 6, puncture needle sealing assembly 7, second sleeve 71, sliding sleeve 72, second sealing member 73, second elastic member 74, fixed snap structure 75, needle sealing assembly 8, first sleeve 81, first sealing member 82, inner sleeve 83, first elastic member 84, pipetting connector 9, chemotherapy pump 10, capsule 101. DETAILED DESCRIPTION

[0052] In order to better illustrate the purpose, technical solutions and advantages of the present invention, the specific embodiments of the present invention are described in further detail below in conjunction with the accompanying drawings and examples. The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention.

[0053] Example 1

[0054] As shown in Figure 1, a split-type dual-chamber pressure-balanced liquid medicine transfer device of the present invention comprises a component I and a component II. The liquid medicine transfer device is in a split state, and components I and II are not fixedly connected.

[0055] Assembly I consists of a first syringe 1, a first needle seat 2 and a dispensing needle assembly 3.

[0056] The first syringe 1 comprises a first syringe barrel 11 , a first piston rod 12 slidable forward and backward along an inner cavity of the first syringe barrel 11 , and a connector 13 provided at a front end.

[0057] The first needle hub 2 is provided with a first channel 21 and a second channel 22 inside, and a protrusion 23 is radially provided on one side near the second channel 22. The length of the protrusion 23 exceeds the radius of the first syringe 11, and an air window 24 is provided at the end of the protrusion 23. The end of the first needle hub 2 is provided with a cavity 28 for connecting and fixing with the connector 13 on the first syringe 1. The end of the first channel 21 is connected to the cavity 28, and the end of the second channel 22 is connected to the air window 24. A sealing plug 25 made of elastic medical silicone is fixedly provided in the air window 24 in an interference fit manner. The sealing plug 25 keeps the air window 24 in a sealed state and isolates it from the outside world.

[0058] By inserting the connector 13 on the first syringe 1 into the cavity 28 at the end of the first needle seat 2 , the first needle seat 2 is connected and fixed to the first syringe 1 .

[0059] The dispensing needle assembly 3 consists of a first needle tube 31 and a second needle tube 32, both arranged in parallel and fixedly connected to the first needle hub 2 with their rear ends embedded therein. The inner lumen of the first needle tube 31 forms the infusion channel, with its rear end communicating with the first channel 21. The inner lumen of the second needle tube 32 forms the exhaust channel, with its rear end communicating with the second channel 22. The first needle tube 31, the first channel 21, and the first syringe 1 are coaxially arranged.

[0060] Component II includes a second syringe 4 , a second needle seat 5 , a puncture needle 6 fixedly connected to the second needle seat 5 , and a puncture needle sealing component 7 .

[0061] The second syringe 4 includes a second syringe 41 of the same dimensions as the first syringe 11, and a second piston rod 42 that can slide back and forth along the inner cavity of the second syringe 41. A support portion 44 is provided on the wall of the second syringe 41. The end structure of the support portion 44 matches the outer wall of the first syringe 11, so that the first syringe 11 and the second syringe 41 can support each other through the support portion 44 when they are arranged side by side and in the same direction, achieving a better fixation effect. A snap structure 43 is provided on the outer wall of the end of the second syringe 41 to facilitate the removable fixation of the first syringe 11 and the second syringe 41 when they are arranged side by side and in the same direction.

[0062] The structural arrangement of the second needle hub 5 and the puncture needle 6 corresponds to the structural arrangement of the air window 24 in the assembly 1. Specifically, the second needle hub 5 and the puncture needle 6 are arranged perpendicular to the second syringe 41. When the first syringe 11 and the second syringe 41 are fixedly connected side by side and in the same direction, the puncture needle 6 can laterally pierce the sealing plug 25 and communicate with the second channel 22 in the first needle hub 2.

[0063] The puncture needle sealing assembly 7 includes a second sleeve 71 coaxially arranged with the puncture needle 6 , a sliding sleeve 72 , a second sealing member 73 and a second elastic member 74 .

[0064] The second sleeve 71 is a hollow cylindrical structure with an open front end and a rear end fixedly connected to the second needle seat 5 .

[0065] The sliding sleeve 72 is a hollow cylindrical structure with front and rear openings. It is designed as a composite cylindrical structure consisting of a front section with a larger inner diameter and a rear section with a smaller inner diameter. The sliding sleeve 72 is disposed within the second sleeve 71. Its outer diameter matches the inner diameter of the second sleeve 71, allowing it to slide axially forward and backward within the second sleeve 71.

[0066] The second sealing member 73 is made of elastic medical grade silicone and is designed to have a T-shaped cross section, completely filling the inner cavity of the sliding sleeve 72. A hole is defined in the second sealing member 73 for the puncture needle 6 to pass through, and the inner diameter of the hole is smaller than the outer diameter of the puncture needle 6.

[0067] The second elastic member 74 is a spring disposed between the sliding sleeve 72 and the second needle hub 5. Relying on the needle hub 5, the second elastic member 74 provides axial elastic support for the front end of the sliding sleeve 72. As shown in FIG1 , in the non-compressed state, the second elastic member 74 is axially extended, and the second sleeve 71 shields the puncture needle 6 within the sleeve. Under the elastic force of the elastic material, the second sealing member 73 tightly wraps the front end of the puncture needle 6, sealing the puncture needle opening.

[0068] To prevent the sliding sleeve 72, filled with the second sealing member 73, from moving outside the second sleeve 71, a radially inwardly facing boss is provided at the front end of the second sleeve 71 to provide a position limiter. Furthermore, a fixed snap-fit ​​structure 75 is provided at the front end of the second sleeve 71. This fixed snap-fit ​​structure 75 mates with the fixed snap-fit ​​groove 27 provided on the raised portion 23 of the first needle hub 2. When assemblies I and II are fixedly connected, the fixed snap-fit ​​structure 75 and the fixed snap-fit ​​groove 27 are mutually connected and fixed.

[0069] Figure 2 shows the liquid medicine transfer device with components I and II fixedly connected. The first and second syringes 11 and 41 are fixedly connected side by side and in the same direction. The air vent 24, containing a sealing plug 25, is inserted into the second sleeve 71 and pushes the sliding sleeve 72, filled with a second sealing member 73, to slide rearward. The second elastic member 74 is axially compressed, allowing the leading end of the puncture needle 6 to pass through the second sealing member 73 and pierce the sealing plug 25, establishing communication with the second channel 22 within the first needle holder 2. Simultaneously, the fixed snap structure 75 is fixedly connected to the fixed slot 27.

[0070] As shown in Figure 2, after Components I and II are fixed and tightly connected, the infusion channel, first channel 21, cavity 28 of first needle holder 2, and first syringe 11 are connected in sequence from front to back, forming closed passage I. The exhaust channel, second channel 22, puncture needle tube, and second syringe 41 are connected in sequence from front to back, forming closed passage II. Closed passages I and II are independent of each other. During the preparation and transfer of liquid medicine, closed passage I is used to transport liquid medicine, while closed passage II is used to transport gas and balance air pressure.

[0071] Example 2

[0072] Figure 3 shows another type of split dual-chamber pressure-balanced liquid medicine transfer device of the present invention. Compared with the liquid medicine transfer device of Example 1, the main difference is that component 1 also includes a needle sealing component 8.

[0073] The needle sealing assembly 8 includes a first sleeve 81 , a first sealing member 82 , an inner sleeve 83 and a first elastic member 84 , which are coaxially arranged with the first needle seat 2 .

[0074] The front end of the first sleeve 81 has a smaller inner diameter, forming a composite cylindrical structure consisting of a first section with a smaller inner diameter and a second section with a larger inner diameter. Two snap-fit ​​structures are symmetrically positioned on the front outer surface of the first section to facilitate secure connection with the pipette connector. The second section has two symmetrical snap-fit ​​holes on its wall near the rear port.

[0075] The first sealing member 82 is made of elastic medical-grade silicone and has an inverted T-shaped cross-section. Its front diameter is equal to the inner diameter of the first barrel section and its length is slightly longer than the axial length of the first barrel section. Its rear diameter is equal to the inner diameter of the second barrel section. While completely filling the inner cavity of the first barrel section and the inner cavity at the front end of the second barrel section, the front end of the first sealing member 82 protrudes beyond the front end of the first sleeve 81. A passageway for the first and second needle tubes 31, 32 is provided within the first sealing member 82. The inner diameter of the passageway is smaller than the outer diameter of the needle tubes.

[0076] The inner diameter and outer diameter of the inner sleeve 83 correspond to the outer diameter of the first needle seat 2 and the inner diameter of the second barrel section of the first sheath 81 respectively. The front end face is closed and a through hole for the first needle tube 31 and the second needle tube 32 to pass through is provided on the end face. The rear port is provided with an annular boss in a radially outward manner, and two buckles matching the clamping holes are symmetrically provided on the outer wall adjacent to the rear port.

[0077] The inner sleeve 83 is inserted into the second barrel section of the first sleeve 81, and a fixed connection between the two is achieved through the cooperation of the buckle and the card hole. At the same time, the front end face of the inner sleeve 83 abuts against the rear end face of the first sealing part 82, and the annular boss at the rear end is exposed in the first sleeve 81 and abuts against the rear end of the first sleeve 81.

[0078] The first elastic member 84 is a spring, which is disposed in the inner sleeve 83 , with its two ends respectively abutting against the front inner surface of the inner sleeve 83 and the front end surface of the first needle seat 2 .

[0079] The side of the first needle seat 2 is symmetrically provided with two L-shaped grooves consisting of an axial groove and a transverse groove. Correspondingly, the rear end of the inner sleeve 83 is symmetrically provided with two slides radially inward, which are embedded in the L-shaped grooves and can slide along the grooves.

[0080] As shown in Figure 3, the needle sealing assembly 8 of component I is in a non-pressurized state, the first elastic member 84 is axially extended, the slide of the inner sleeve 83 is located at the front end of the axial groove on the side of the first needle seat 2, the first sheath 81 shields the first needle tube 31 and the second needle tube 32 inside the first sheath 81, and under the elastic force of the silicone, the first sealing member 82 tightly wraps the front end of the first needle tube 31 and the second needle tube 32, sealing the front end channel openings of the infusion channel and the exhaust channel.

[0081] The drug transfer device of the present invention is designed to be split. After preparing the drug solution (the drug solution is located in the first syringe 11), the user can easily separate component I and component II. The sealing plug 25 then reseals the second channel 22. The separate component I can be easily docked with a pipette connector for drug transfer or installed on a push injection device for quantitative drug transfer.

[0082] Applications for pipetting into chemotherapy pumps are shown in Figure 4 and include:

[0083] The first step is to fix component I to one end of the pipetting connector 9 (provided with a rubber plug) through a snap fastener, and fix the other end of the pipetting connector 9 to the infusion tube interface of the chemotherapy pump 10.

[0084] In the second step, the first syringe 1 is pushed forward, causing the front ends of the first and second needle tubes 31, 32, including the front channel openings of the infusion and exhaust channels, to pass through the first sealing member 82 and, after piercing the rubber stopper, communicate with the inner cavity of the pipette connector 9. The slide of the inner sleeve 83 slides synchronously backward along the axial groove and, by rotating the first syringe 1 or the first sheath 81, moves into the transverse groove, thereby limiting the axial movement of the needle seal assembly 8 and achieving a fixed position.

[0085] In the third step, the first piston rod 12 is pushed, pushing the prepared liquid medicine in the first syringe 11 into the chemotherapy pump 10 through the infusion channel. The bladder in the chemotherapy pump 10 gradually expands, increasing the pressure. During this process, the high-pressure liquid medicine will not leak out of the exhaust channel because the exhaust channel is blocked by the sealing plug 25.

[0086] Example 3

[0087] Figure 5 shows another embodiment of the present invention's split, dual-chamber, pressure-balanced drug transfer device. Compared to the drug transfer device of Example 2, this device differs primarily in that a rotatable stop valve 26 is provided within the second channel 22 of the first needle hub 2 to control the flow or isolation of the second channel 22. The valve has a through hole disposed therein. By rotating the stop valve 26 to align or offset the through hole with the second channel, the two channels can be easily connected or isolated.

[0088] Figures 6a-6c are representative photos of the liquid medicine transfer device. Figure 6a is a photo of the sample in the assembled state;

[0089] Figure 6b is a photo of the sample in a split state; Figure 6c is a photo of the sample equipped with various connectors.

[0090] Unlike existing dual-chamber liquid transfer devices, the liquid transfer device of the present invention can be easily adapted to existing push injection devices for quantitative liquid transfer. As shown in FIG7 , the method for using the liquid transfer device on a single-channel quantitative push injection device includes the following steps:

[0091] In the first step, after the liquid medicine is prepared (it is in the first syringe 11), components I and II are separated, and the check valve 26 is rotated so that its internal through hole is offset from the second channel 22. At this point, the sealing plug 25 reseals the second channel 22, and the check valve 26 blocks the second channel 22, providing a double guarantee to ensure the airtightness of the exhaust channel.

[0092] The second step is to fix the component I to one end of the pipetting connector 9 (with a rubber plug) through a snap fastener, and fix the other end of the pipetting connector 9 to the infusion tube interface.

[0093] In the third step, the first syringe 1 is pushed forward, causing the front ends of the first and second needle tubes 31, 32, including the front channel openings of the infusion and exhaust channels, to pass through the first sealing member 82 and, after piercing the rubber stopper, communicate with the inner cavity of the pipette connector 9. The slide of the inner sleeve 83 slides synchronously backward along the axial groove and, by rotating the first syringe 1 or the first sheath 81, moves into the transverse groove, thereby limiting the axial movement of the needle seal assembly 8 and achieving a fixed position.

[0094] The fourth step is to pull the fixing hook on the quantitative pusher to fix the first syringe 11 on the quantitative pusher, and install the end neck of the first piston rod 12 on the fixing clamp, so that the liquid pushing end abuts against the rear end surface of the first piston rod 12.

[0095] The fifth step is to set the infusion program and push the first piston rod 12 at a preset speed so that the liquid medicine in the first syringe 11 is quantitatively delivered to the infusion tube.

[0096] In the above application, the connection between the component 1 and the quantitative pusher will not leak. The first syringe 11 can be stably mounted on the quantitative pusher without taking up space in the quantitative pusher.

[0097] It is easy to understand that the drug liquid transfer device of the present invention is also applicable to a quantitative injector with two or more channels.

[0098] Example 4

[0099] FIG8 shows another form of the split double-chamber air pressure balanced liquid medicine transfer device of the present invention. Compared with the liquid medicine transfer device of Example 3, the main difference is that the dispensing needle assembly 3 is a double-layer columnar structure, consisting of an inner needle tube and an outer needle tube that are integrally formed and fixedly connected to each other. The inner needle tube is inserted into the outer needle tube, and both ends extend to the outside of the outer needle tube. At this time, the inner column channel formed by the inner cavity of the inner needle tube serves as an exhaust channel, and the side ring channel formed by the cavity between the outer needle tube and the inner needle tube serves as an infusion channel. The front end of the inner needle tube is a pointed tip and is provided with a side opening, and the front end side wall of the outer needle tube is provided with a side opening.

[0100] The above embodiments primarily illustrate the basic principles, main features, and advantages of the present invention. Those skilled in the art will appreciate that the present invention is not limited to the above embodiments. The above embodiments and descriptions merely illustrate the principles of the present invention. Various changes and modifications may be made to the present invention without departing from the spirit and scope of the present invention, and such changes and modifications fall within the scope of the invention as claimed.

Claims

1. A split double-chamber pressure-balanced liquid medicine transfer device, comprising component I and component II, wherein: Component I comprises a first syringe, a first needle seat and a dispensing needle assembly, wherein the first needle seat is connected and fixed to the first syringe via a connector on the first syringe, and the dispensing needle assembly is fixedly connected to the first needle seat; The first needle seat is provided with a first channel and a second channel inside, an air window is provided on the side, and a cavity for connecting and fixing with the connector on the first syringe is provided at the end; the end of the first channel is connected to the cavity, and the end of the second channel is connected to the air window; a sealing plug is provided in the air window; The medication dispensing needle assembly includes an infusion channel and an exhaust channel, wherein the infusion channel is communicated with the first channel, and the exhaust channel is communicated with the second channel; Component II includes a second syringe, a second needle holder, and a puncture needle fixedly connected to the second needle holder; When components I and II are fixedly connected, the puncture needle of component II pierces the sealing plug in the air window of component I and communicates with the second channel in the first needle seat; When component I and component II are separated, the sealing plug in the air window keeps the air window in a sealed state.

2. The liquid medicine transfer device according to claim 1, characterized in that: The first syringe comprises a first syringe barrel and a first piston rod which can slide forward and backward along the inner cavity in the first syringe barrel; the second syringe comprises a second syringe barrel and a second piston rod which can slide forward and backward along the inner cavity in the second syringe barrel; Preferably, when the components I and II are fixedly connected, the first injection cylinder and the second injection cylinder are fixedly connected in a side-by-side and equidirectional manner; Further preferably, a snap-fit ​​structure is provided on the outer wall of at least one of the first syringe and the second syringe, so that the first syringe and the second syringe can be detachably fixed to each other when they are arranged side by side and in the same direction; and / or, at least one of the first syringe and the second syringe is provided with a supporting portion on the cylinder wall, and the end structure of the supporting portion matches the outer side wall of the opposite syringe, so that the first syringe and the second syringe can support each other through the supporting portion when they are arranged side by side and in the same direction.

3. The liquid medicine transfer device according to claim 1, characterized in that: A pass-stop module for controlling the penetration or isolation of the second channel is arranged in the second channel of the first needle seat; Preferably, the on-off module is a rotatable on-off valve, in which a through hole is arranged; the on-off valve is rotated so that the through hole is aligned or misaligned with the second channel, thereby achieving the connection or isolation of the channels on both sides; or, The on-off module is a control valve, which includes a slider and a slide groove which is arranged through the first needle seat and passes through the second channel radially. The slider is slidably arranged in the slide groove, and a through hole is arranged in the slider. When the slider slides to a preset position, the two ends of the through hole are respectively connected to the second channel. When the slider slides out of the preset position, the outer side surface of the slider blocks the second channel.

4. The liquid medicine transfer device according to claim 1, characterized in that: The first needle seat is radially provided with a protrusion on one side close to the second channel, and the air window is provided at the end of the protrusion; preferably, the length of the protrusion exceeds the radius of the first injection cylinder.

5. The liquid medicine transfer device according to claim 1, characterized in that: The medicine dispensing needle assembly is composed of a first needle tube and a second needle tube which are arranged in parallel and fixedly connected to the first needle seat in a rear end embedded manner; The inner cavity of the first needle tube constitutes an infusion channel, and the rear port is communicated with the first channel; the inner cavity of the second needle tube constitutes an exhaust channel, and the rear port is communicated with the second channel.

6. The liquid medicine transfer device according to claim 1, characterized in that: The dispensing needle assembly is a double-layer columnar structure, having an inner column channel and a side ring channel, wherein one of the channels serves as an infusion channel and the other serves as an exhaust channel; preferably, the dispensing needle assembly consists of an inner needle tube and an outer needle tube, the inner needle tube is inserted into the outer needle tube, and both ends extend outside the outer needle tube, at this time, the inner column channel is formed by the inner cavity of the inner needle tube, and the side ring channel is formed by the cavity between the outer needle tube and the inner needle tube.

7. The liquid medicine transfer device according to claim 1, characterized in that: Component I further comprises a needle sealing component, wherein the needle sealing component comprises a first sleeve, a first sealing member and a first elastic member arranged coaxially with the first needle seat; wherein, The first sleeve is a hollow cylindrical structure with front and rear openings, and is axially movably sleeved on the front end of the first needle seat; The first sealing member is made of elastic material and is fixedly arranged in the front end cylinder of the first sleeve; a hole for the needle tube to pass through is provided in the first sealing member, and the inner diameter of the hole is smaller than the outer diameter of the needle tube; The first elastic member is disposed between the first sealing member and the first needle seat, and relies on the needle seat to provide axial elastic support for the first sealing member at the front end; In the non-pressurized state, the first elastic member stretches axially, the first sleeve shields the needle tube inside the sleeve, and under the elastic force of the elastic material, the first sealing member tightly wraps the front end of the needle tube, sealing the front end channel openings of the infusion channel and the exhaust channel; Under pressure, the first elastic member is axially compressed, and the front end of the needle tube including the front channel openings of the infusion channel and the exhaust channel can pass through the hole of the first sealing member and out of the first sleeve.

8. The liquid medicine transfer device according to claim 7, characterized in that: The needle sealing assembly comprises a first sleeve, a first sealing member, a first elastic member and an inner sleeve which are coaxially arranged, wherein: The front end of the first sleeve has a smaller inner diameter, forming a composite cylindrical structure consisting of a first barrel section with a smaller inner diameter and a second barrel section with a larger inner diameter; The first sealing member is designed to have an inverted T-shaped cross section, with a front diameter corresponding to the inner diameter of the first barrel section, and a rear diameter corresponding to the inner diameter of the second barrel section, so that the first sealing member can fill at least part of the inner cavity of the second barrel section while completely filling the inner cavity of the first barrel section; The inner diameter of the inner sleeve corresponds to the outer diameter of the first needle seat, and the outer diameter of the inner sleeve corresponds to the inner diameter of the second barrel section of the first sleeve. The front end face of the inner sleeve is closed and a through hole for the needle tube to pass through is provided on the end face. The inner sleeve is fixedly connected to the second barrel section of the first sleeve, and the front end face abuts against the rear end face of the first sealing member. The first elastic member is arranged in the inner sleeve, and two ends thereof are respectively in contact with the front end inner surface of the inner sleeve and the front end surface of the first needle seat.

9. The liquid medicine transfer device according to claim 8, characterized in that: The outer wall of the inner sleeve is provided with a buckle, and the second barrel section of the first sleeve is provided with a corresponding buckle hole, and when the inner sleeve is inserted into the first sleeve, the buckle and the buckle hole cooperate to achieve a fixed connection between the first sleeve and the inner sleeve; Preferably, the rear port of the inner sleeve is provided with an annular boss in a radially outward manner, and when the front end face of the inner sleeve abuts against the rear end face of the first sealing member, the annular boss at the rear end is exposed from the first sleeve and abuts against the rear end of the first sleeve.

10. The liquid medicine transfer device according to claim 8, characterized in that: Buckle structures are provided on the front inner surface of the inner sleeve and the front end surface of the first needle seat, thereby achieving fixed connection with the first elastic member.

11. The liquid medicine transfer device according to claim 8, characterized in that: An L-shaped groove consisting of an axial groove and a transverse groove is arranged on the side of the first needle seat, and a slide is arranged radially inward at the rear end of the inner sleeve, and the slide is embedded in the L-shaped groove and can slide along the groove.

12. The liquid medicine transfer device according to claim 7 or 8, characterized in that: The front end surface of the first sealing member protrudes beyond the front end surface of the first sleeve.

13. The liquid medicine transfer device according to claim 7 or 8, characterized in that: A fixed connection structure adapted to the connector is provided at the front end of the first sleeve so as to facilitate fixed connection with the connector.

14. The liquid medicine transfer device according to claim 4, characterized in that: The second needle seat and puncture needle in component II are arranged perpendicular to the second syringe. When the first syringe and the second syringe are fixedly connected side by side and in the same direction, the puncture needle transversely pierces the sealing plug to communicate with the second channel in the first needle seat.

15. The liquid medicine transfer device according to claim 1, characterized in that: Component II also includes a puncture needle sealing component, which includes a second sleeve coaxially arranged with the puncture needle, a second sealing member and a second elastic member; wherein the second sleeve is a hollow cylindrical structure with an open front end, and a rear end fixedly connected to the second needle seat; The second sealing member is made of elastic material and is fixedly arranged in the front end cylinder of the second sleeve; a hole for the puncture needle to pass through is provided in the second sealing member, and the inner diameter of the hole is smaller than the outer diameter of the puncture needle; The second elastic member is disposed between the second sealing member and the second needle seat, and relies on the needle seat to provide axial elastic support for the second sealing member at the front end; In the non-pressurized state, the second elastic member stretches axially, the second sleeve shields the puncture needle inside the sleeve, and under the elastic force of the elastic material, the second sealing member tightly wraps the front end of the puncture needle to seal the puncture needle opening inside; Under pressure, the second sealing member slides toward the rear end, the second elastic member is axially compressed, and the front end of the puncture needle passes out of the second sealing member.

16. The liquid medicine transfer device according to claim 15, characterized in that: The puncture needle sealing assembly also includes a sliding sleeve coaxially arranged with the puncture needle; the sliding sleeve is a hollow cylindrical structure with front and rear openings, which is arranged in the second sleeve, and its outer diameter is adapted to the inner diameter of the second sleeve, and can slide forward and backward along the axial direction in the second sleeve, and the second sealing member is filled in the sliding sleeve; Preferably, the sleeve is designed as a composite cylindrical structure consisting of a front barrel section with a larger inner diameter and a rear barrel section with a smaller inner diameter; accordingly, the second sealing member is designed as a structure with a T-shaped cross-section, so that the second sealing member can completely fill the inner cavity of the sleeve.

17. The liquid medicine transfer device according to claim 15 or 16, characterized in that: The first needle seat in component I is radially provided with a protrusion on one side close to the second channel, and the air window is provided at the end of the protrusion; the second needle seat, the puncture needle and the puncture needle sealing assembly in component II are arranged in a manner perpendicular to the second syringe; when the first syringe and the second syringe are fixedly connected in a side-by-side and unidirectional manner, the air window with a sealing plug inside is inserted into the second sleeve and pushes the second sealing part or the sliding sleeve filled with the second sealing part to slide toward the rear end, the second elastic part is axially compressed, and the front end of the puncture needle passes through the second sealing part and pierces the sealing plug to achieve communication with the second channel in the first needle seat.

18. The liquid medicine transfer device according to claim 15 or 16, characterized in that: A fixed buckle structure is arranged at the front end of the second sleeve, and a fixed buckle groove cooperating with the fixed buckle structure is arranged on the raised portion of the first needle seat; when component I and component II are fixedly connected, the fixed buckle structure and the fixed buckle groove are fixed to each other.

19. Use of the drug solution transfer device according to any one of claims 1 to 18 in quantitative infusion.

20. A quantitative infusion device, characterized in that: A drug liquid transfer device comprising any one of claims 1-18.

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