Compositions and methods for treating a disease or disorder associated with senescence

By employing Muse cell-derived extracellular vesicles that encapsulate senolytic agents, the accumulation of senescent cells is addressed, leading to the reversal of senescence-associated phenotypes and improved health outcomes.

WO2025049883A1PCT designated stage expired Publication Date: 2025-03-06JLM EXOGRADE LLC
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Patent Information

Application Number
PCT/US2024/044637
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2023-08-30
Filing Date
2024-08-30
Publication Date
2025-03-06

AI Technical Summary

Technical Problem

Cellular senescence leads to the accumulation of senescent cells, which contribute to aging and age-related diseases, as well as adverse effects from cancer treatments, by secreting inflammatory factors and disrupting tissue function.

Method used

The use of extracellular vesicles (EVs) derived from Muse cells that encapsulate or comprise senolytic agents, promoting the selective removal of senescent cells and reversing senescence-associated phenotypes.

Benefits of technology

The described approach effectively reduces the number of senescent cells, thereby mitigating the detrimental effects of senescence on tissues and organs, and improving overall health and cosmetic appearances.

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Abstract

The invention relates to compositions (e.g., pharmaceutical compositions), uses, methods, non-therapeutic and therapeutic methods related to senolytic agents encapsulated or comprised in Muse cell derived extracellular vesicles (e.g. exosomes). Such compositions and methods are useful for specifically killing senescent cells and reverting any symptoms, disorders or diseases associated with senescence.
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Citation Information

Patent Citations

  • Formation of Three-Dimensional Organ from Pluripotent Stem Cells

    US20200362315A1

  • Methods for culturing mesenchymal stem cells, compositions and implementations thereof

    WO2023017539A1

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