Programmable miniaturized high-voltage pulse generation circuit and implantable medical device

Abstract

Disclosed in the present invention are a programmable miniaturized high-voltage pulse generation circuit and an implantable medical device. The circuit comprises a high-voltage pulse generation chip and a high-voltage energy storage element. The high-voltage pulse generation chip is at least integrated with a programmable low-voltage pulse generation circuit, a high-voltage switch module and a high-voltage power source, wherein the programmable low-voltage pulse generation circuit is used for generating a required low-voltage pulse by means of program control, the high-voltage switch module is used for converting the low-voltage pulse into a high-voltage pulse output, and the high-voltage power source is used for providing a high voltage for a high-voltage switch; and the high-voltage energy storage element is connected to the high-voltage power source and is used for supporting the instantaneous high-power operation of the high-voltage switch module. In the embodiments of the present invention, an integrated high-voltage pulse generation chip and an off-chip miniaturized high-voltage energy storage element are used for performing a circuit miniaturization design, so as to form a programmable miniaturized high-voltage pulse generation circuit, thus greatly reducing the size of the high-voltage pulse generation circuit, so as to be better applied to an implantable medical device.

Description

A programmable miniaturized high-voltage pulse generating circuit and implantable medical device Technical Field

[0001] The present invention relates to the technical field of implantable medical devices, and in particular to a programmable miniaturized high-voltage pulse generating circuit and an implantable medical device. Background Art

[0002] Electroporation, also known as electrotransfection, uses a high-intensity electric field to transiently increase the permeability of cell membranes, allowing them to absorb foreign molecules from the surrounding medium. This technique can introduce nucleotides, DNA and RNA, proteins, carbohydrates, dyes, and viral particles into prokaryotic and eukaryotic cells. Electroporation is a valuable and effective alternative to other physical and chemical transformation methods. Implantable electroporation devices have enormous potential for applications in gene therapy and other areas, but electroporation requires a programmable high-voltage pulse generator. Furthermore, in vivo ultrasound imaging using implantable devices requires the conversion of high-frequency electrical signals into sound waves to achieve high resolution, thus also requiring a high-voltage pulse generation circuit to provide the high-voltage pulses driving the ultrasonic transducer. However, current programmable high-voltage pulse generators used for electroporation and ultrasound imaging are relatively large, making them difficult to implant. Specifically, implantable medical devices often lack sufficient space for bulky circuitry such as transformers and independent high-voltage power supplies.

[0003] Summary of the Invention

[0004] The present invention aims to solve at least one of the technical problems existing in the prior art. To this end, the present invention proposes a programmable miniaturized high-voltage pulse generating circuit, which solves the problem that the programmable high-voltage pulse generator in the prior art is large in size and difficult to implant.

[0005] The present invention also provides an implantable medical device.

[0006] A programmable miniaturized high-voltage pulse generating circuit according to an embodiment of the first aspect of the present invention comprises:

[0007] A high-voltage pulse generation chip, which integrates at least a programmable low-voltage pulse generation circuit, a high-voltage switch module, and a high-voltage power supply. The programmable low-voltage pulse generation circuit is used to generate the required low-voltage pulses under program control, the high-voltage switch module is used to convert the low-voltage pulses into high-voltage pulse outputs, and the high-voltage power supply is used to provide high voltage for the high-voltage switch.

[0008] The high-voltage energy storage element is connected to the high-voltage power supply and is used to support the instantaneous high-power operation of the high-voltage switch module.

[0009] The programmable miniaturized high-voltage pulse generating circuit according to the embodiment of the present invention has at least the following beneficial effects:

[0010] By integrating a programmable low-voltage pulse generating circuit, a high-voltage switch module and a high-voltage power supply on a high-voltage pulse generating chip, the programmable low-voltage pulse generating circuit is used to program-control the generation of low-voltage pulses with the same frequency, number of pulses, duty cycle and other information as the required high-voltage pulses, the high-voltage switch module is used to convert the low-voltage pulses into high-voltage pulses and output them, and the high-voltage power supply is used to convert the low-voltage power supply of the chip into the high voltage required by the high-voltage switch module. Since the instantaneous power of the high-voltage switch is extremely large when a high-voltage pulse occurs, the high-voltage power supply is output to a high-voltage energy storage element to support the instantaneous high-power operation of the high-voltage switch. The embodiment of the present invention uses an integrated high-voltage pulse generating chip and an off-chip miniaturized high-voltage energy storage element to perform circuit miniaturization design, thereby forming a programmable miniaturized high-voltage pulse generating circuit, thereby greatly reducing the size of the high-voltage pulse generating circuit so that it can be well applied to implantable medical devices.

[0011] According to some embodiments of the present invention, the high voltage power supply includes:

[0012] a boost circuit, connected to the high-voltage energy storage element, for charging the high-voltage energy storage element;

[0013] A voltage stabilizing circuit is respectively connected to the boost circuit, the high-voltage energy storage element, and the high-voltage switch module. The voltage stabilizing circuit is used to provide a high voltage for the high-voltage switch module. The output voltage of the voltage stabilizing circuit is lower than the lowest voltage value of the high-voltage energy storage element during the discharge cycle.

[0014] According to some embodiments of the present invention, the boost circuit includes:

[0015] a charge pump, connected to the high-voltage energy storage element and the voltage stabilizing circuit, respectively, for converting a low supply voltage into a high voltage to charge the high-voltage energy storage element;

[0016] The clock generating circuit is connected to the charge pump and is used to generate a square wave clock signal to drive the charge pump.

[0017] According to some embodiments of the present invention, the programmable low-voltage pulse generating circuit includes:

[0018] a pulse generating module connected to the high-voltage switch module, and configured to generate low-voltage pulses with required pulse information under program control, wherein the pulse information includes at least one of frequency, number of pulses, duty cycle, and polarity;

[0019] The control module is at least connected to the pulse generating module.

[0020] According to some embodiments of the present invention, the pulse generating module includes at least any one of a programmable frequency source, a switch, a pulse width modulator, and a polarity controller, all of which are connected to the control module; the programmable frequency source is used to output a square wave signal with a specific frequency and number of cycles; the switch is connected to the programmable frequency source, and the switch is used to control the number of pulses of the square wave signal; the pulse width modulator is connected to the switch, and the pulse width modulator is used to adjust the duty cycle of the square wave signal; the polarity controller is connected to the pulse width modulator and the high-voltage switch module, and the polarity controller is used to control the polarity of the square wave signal.

[0021] According to some embodiments of the present invention, the pulse generation module includes a DDS signal generator, and the DDS signal generator is connected to the control module and the high-voltage switch module respectively.

[0022] According to some embodiments of the present invention, the high-voltage switch module includes:

[0023] A level conversion circuit, connected to the pulse generating module and the voltage stabilizing circuit, for converting low-voltage pulses into high-voltage pulses;

[0024] The high-voltage switch is connected to the level conversion circuit and the voltage stabilizing circuit, and is used for outputting high-voltage pulses.

[0025] According to some embodiments of the present invention, the high-voltage pulse generating chip is arranged on a top layer of the circuit, and the high-voltage energy storage element is arranged on a bottom layer of the circuit.

[0026] According to some embodiments of the present invention, the high-voltage pulse generation chip integrates a plurality of the programmable low-voltage pulse generation circuits, a plurality of the high-voltage switch modules, and a plurality of the high-voltage power supplies to achieve multi-channel high-voltage pulse output.

[0027] An implantable medical device according to an embodiment of the second aspect of the present invention includes a device body and a programmable miniaturized high-voltage pulse generating circuit as described in any one of the embodiments of the first aspect of the present invention.

[0028] The implantable medical device according to the embodiment of the present invention has at least the following beneficial effects:

[0029] By applying the programmable miniaturized high-voltage pulse generating circuit of the embodiment of the present invention to implantable medical devices, on the one hand, high-voltage pulses can be provided for driving the device body to meet the application requirements of medical technical means such as electroporation and ultrasonic imaging; on the other hand, the programmable miniaturized high-voltage pulse generating circuit has the characteristics of integration and miniaturization, which can achieve a good implantation effect, and is therefore in line with the current development trend of miniaturization and refinement of implantable medical devices, which is conducive to the implementation of minimally invasive surgery with less trauma and shorter patient recovery time. At the same time, it can also help reduce the pressure on healthcare infrastructure, that is, it helps to improve the cost-effectiveness of medical institutions and patients.

[0030] Additional aspects and advantages of the present invention will be set forth in part in the description which follows and, in part, will be obvious from the description which follows, or may be learned by practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] The above and / or additional aspects and advantages of the present invention will become apparent and readily understood from the description of the embodiments with reference to the following drawings, in which:

[0032] FIG1 is a schematic diagram of a programmable miniaturized high-voltage pulse generating circuit according to an embodiment of the present invention;

[0033] FIG2 is a schematic diagram of a high-voltage power supply according to an embodiment of the present invention;

[0034] FIG3 is a schematic diagram of the working strategy of the high-voltage energy storage element and the high-voltage power supply according to an embodiment of the present invention;

[0035] FIG4 is a circuit diagram of a programmable miniaturized high-voltage pulse generating circuit according to an embodiment of the present invention;

[0036] FIG5 is a circuit diagram of a programmable miniaturized high-voltage pulse generating circuit according to another embodiment of the present invention;

[0037] FIG6 is a physical design diagram of a programmable miniaturized high-voltage pulse generating circuit according to an embodiment of the present invention. DETAILED DESCRIPTION

[0038] The following describes embodiments of the present invention in detail. Examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are intended only to explain the present invention and are not to be construed as limiting the present invention.

[0039] In the description of the present invention, it should be understood that descriptions involving orientation, such as the orientation or positional relationship indicated by up, down, etc., are based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0040] In the description of the present invention, "a plurality" refers to more than two. The use of "first" or "second" is solely for the purpose of distinguishing technical features and should not be construed as indicating or implying relative importance, or implicitly indicating the number of the indicated technical features, or implicitly indicating the order of the indicated technical features.

[0041] In the description of the present invention, unless otherwise clearly defined, terms such as setting, installing, and connecting should be understood in a broad sense, and technicians in the relevant technical field can reasonably determine the specific meanings of the above terms in the present invention based on the specific content of the technical solution.

[0042] Referring to Figure 1, an architectural diagram of a programmable, miniaturized high-voltage pulse generating circuit according to one embodiment of the present invention is shown. The circuit includes a high-voltage pulse generating chip and a high-voltage energy storage element. The high-voltage pulse generating chip integrates at least a programmable low-voltage pulse generating circuit, a high-voltage switching module, and a high-voltage power supply. The programmable low-voltage pulse generating circuit generates the required low-voltage pulses under program control. The high-voltage switching module converts the low-voltage pulses into high-voltage pulse outputs. The high-voltage power supply provides high voltage for the high-voltage switch. The high-voltage energy storage element is connected to the high-voltage power supply to support the instantaneous high-power operation of the high-voltage switching module.

[0043] As shown in Figure 1, it can be understood that the high-voltage pulse generation chip mainly integrates three modules or circuits, specifically, a programmable low-voltage pulse generation circuit, a high-voltage switch module and a high-voltage power supply. First, the programmable low-voltage pulse generation circuit sets the pulse information by using a written program and generates a corresponding low-voltage pulse; then the high-voltage switch module pulls up the low level of the low-voltage pulse to obtain a high-voltage pulse and outputs it, so as to realize the function of generating high-voltage pulses required by the embodiment of the present invention, while the pulse information contained remains consistent with the low-voltage pulse; and the high-voltage power supply is responsible for converting the low-voltage power supply obtained by the chip from the battery into a high voltage to provide high-voltage power supply to the high-voltage switch module; the high-voltage energy storage element is connected to the high-voltage power supply to store electrical energy and release electrical energy again when needed, that is, to complete the charging and discharging of the high-voltage power supply electrical energy. In some embodiments, the high-voltage energy storage element can be a high-voltage capacitor. It should be noted that in some embodiments, the high-voltage pulse can be a positive pulse, a negative pulse, or a positive and negative pulse.

[0044] In this embodiment, a programmable low-voltage pulse generating circuit, a high-voltage switch module, and a high-voltage power supply are integrated on a high-voltage pulse generating chip. The programmable low-voltage pulse generating circuit is used to program-control the generation of low-voltage pulses with the same frequency, number of pulses, duty cycle, and other information as the required high-voltage pulses. The high-voltage switch module is used to convert the low-voltage pulses into high-voltage pulses and output them. The high-voltage power supply is used to convert the low-voltage power supply of the chip into the high voltage required by the high-voltage switch module. Since the instantaneous power of the high-voltage switch is extremely large when a high-voltage pulse occurs, the high-voltage power supply is output to a high-voltage energy storage element to support the instantaneous high-power operation of the high-voltage switch. The embodiment of the present invention uses an integrated high-voltage pulse generating chip and an off-chip miniaturized high-voltage energy storage element to perform circuit miniaturization design, thereby forming a programmable miniaturized high-voltage pulse generating circuit. This greatly reduces the size of the high-voltage pulse generating circuit, making it well suited for use in implantable medical devices.

[0045] In some embodiments, as shown in Figure 2, the high-voltage power supply includes a boost circuit and a voltage regulator circuit. The boost circuit is connected to the high-voltage energy storage element and is used to charge the high-voltage energy storage element. The voltage regulator circuit is connected to the boost circuit, the high-voltage energy storage element, and the high-voltage switch module, respectively. The voltage regulator circuit is used to provide a high voltage to the high-voltage switch module. The output voltage of the voltage regulator circuit is lower than the lowest voltage of the high-voltage energy storage element during the discharge cycle.

[0046] Preferably, referring to FIG. 2 , FIG. 4 or FIG. 5 , the voltage stabilizing circuit adopts a linear voltage stabilizing circuit.

[0047] Specifically, referring to Figure 2, it can be understood that since some application scenarios such as ultrasound and electro-transfer require multiple continuous pulse signals with constant amplitude, the voltage drop of the ultrasonic energy storage device will cause the output pulse signal amplitude to change. Therefore, the high-voltage power supply includes a boost circuit and a voltage stabilization circuit. The boost circuit converts the low-voltage power supply V provided by the battery into a voltage regulator circuit. L Boost to V C , thereby charging the high-voltage energy storage element; the voltage stabilizing circuit can obtain high voltage from it, thereby providing high voltage power to the high-voltage switch module.

[0048] Furthermore, it should be noted that for implantable medical devices, whether for electroporation or ultrasound imaging, only short-duration pulse signals are required. To further reduce circuit size for application in implantable medical devices, the high-voltage energy storage element and high-voltage power supply of the embodiments of the present invention can be combined to adopt an operating strategy of "slow charging during working intervals" and "instantaneous discharge during working cycles."

[0049] Specifically, the high-voltage pulse generator generates significant power consumption during operation, which can cause a transient voltage drop across the energy storage device. Conventional designs use large capacitors to provide robust energy storage capacity to mitigate the voltage drop caused by transient discharge. However, in the circuits of the present invention, this voltage drop is mitigated by a voltage-stabilizing circuit. Therefore, the output voltage of the voltage-stabilizing circuit must be set slightly lower than the lowest voltage reached by the high-voltage energy storage element during the discharge cycle.

[0050] 3, which shows the voltage V of the high-voltage energy storage element during a typical working cycle. C It can be seen from the change that the charging cycle is significantly longer than the discharging cycle. H is the output voltage of the voltage regulator circuit, V H It is in a relatively stable state over time.

[0051] In this embodiment, by adopting the above-described operating strategy, both the current output requirements of the high-voltage power supply and the energy storage capacity requirements of the high-voltage energy storage element are reduced. Specifically, since the high-voltage energy storage element has a longer charging time, the current output capacity requirements of the boost circuit are reduced, thereby reducing the size of the boost circuit on the chip. At the same time, since the voltage drop of the high-voltage energy storage element during discharge is smoothed by the voltage stabilization circuit, the energy storage capacity requirements of the high-voltage energy storage element are reduced, allowing the use of smaller energy storage devices.

[0052] In some embodiments, as shown in FIG4 or FIG5 , the boost circuit includes a charge pump and a clock generation circuit. The charge pump is connected to the high-voltage energy storage element and the voltage stabilization circuit, respectively, to convert the low supply voltage into a high voltage to charge the high-voltage energy storage element. The clock generation circuit is connected to the charge pump to generate a square wave clock signal to drive the charge pump.

[0053] Specifically, referring to FIG4 or FIG5, FIG4 and FIG5 are circuit diagrams of two different embodiments of the present invention. It can be understood that the high voltage power supply includes a clock generating circuit that can generate a square wave clock signal with a fixed frequency. The square wave clock signal can drive the charge pump so that the charge pump converts the low power supply voltage V L Raise the voltage to Vc and charge the high-voltage energy storage element.

[0054] In some embodiments, as shown in FIG4 or FIG5 , the programmable low-voltage pulse generation circuit includes a pulse generation module and a control module. The pulse generation module is connected to the high-voltage switch module and is configured to generate low-voltage pulses with desired pulse information under program control. The pulse information includes at least one of frequency, number of pulses, duty cycle, and polarity. The control module is at least connected to the pulse generation module.

[0055] Specifically, referring to FIG4 or FIG5, it can be understood that the pulse generation module can generate a low-voltage pulse with specific pulse information, and the pulse information generally includes frequency, number of pulses, duty cycle, and polarity. Furthermore, the pulse information is specifically determined by the control module through programming, so the control module can control the low-voltage pulse output of the pulse generation module to generate the required high-voltage pulse accordingly. In addition, preferably, the control module is also connected to the voltage stabilizing circuit, because the amplitude of the high-voltage pulse output by the high-voltage switch module depends on the power supply voltage V provided by the voltage stabilizing circuit. H Therefore, the control module can also control the voltage stabilizing circuit, thereby further realizing the output of high-voltage pulses with different peak voltages.

[0056] In this embodiment, by using the control module to program and control the pulse generating module and the voltage stabilizing circuit, the generation of programmable high-voltage pulses can be achieved. Specifically, the high-voltage pulse has a programmable frequency, number of pulses, duty cycle, pulse polarity and peak voltage.

[0057] In some embodiments, as shown in Figure 4, the pulse generating module includes at least any one of a programmable frequency source, a switch, a pulse width modulator, and a polarity controller, all of which are connected to the control module; the programmable frequency source is used to output a square wave signal with a specific frequency and number of cycles; the switch is connected to the programmable frequency source, and the switch is used to control the number of pulses of the square wave signal; the pulse width modulator is connected to the switch, and the pulse width modulator is used to adjust the duty cycle of the square wave signal; the polarity controller is connected to the pulse width modulator and the high-voltage switch module, and the polarity controller is used to control the polarity of the square wave signal.

[0058] Specifically, referring to Figure 4, it can be understood that in one embodiment of the present invention, the programmable frequency source outputs a square wave signal with a specific frequency and number of cycles; the number of pulses is controlled by the on-time of the switch; and the pulse width modulator can adjust the duty cycle of the square wave signal; the polarity controller specifically controls the signal polarity of the differential output port to achieve adjustment of the high-voltage pulse polarity.

[0059] In some embodiments, as shown in FIG5 , the pulse generation module includes a DDS signal generator, and the DDS signal generator is connected to the control module and the high-voltage switch module respectively.

[0060] Specifically, referring to FIG5 , it can be understood that, in another embodiment of the present invention, the programming of the pulse information is achieved through direct digital synthesis, that is, it is completed using a DDS signal generator, and the output of the DDS is a pulse signal with a specific frequency, number of pulses, duty cycle, and polarity.

[0061] In some embodiments, as shown in FIG4 or FIG5 , the high-voltage switch module includes a level conversion circuit and a high-voltage switch. The level conversion circuit is connected to the pulse generation module and the voltage stabilization circuit to convert low-voltage pulses into high-voltage pulses; the high-voltage switch is connected to the level conversion circuit and the voltage stabilization circuit to output high-voltage pulses.

[0062] Specifically, referring to FIG4 or FIG5, it can be understood that the voltage stabilizing circuit generates V H The high voltage power supply is provided to the level conversion circuit and the high voltage switch respectively. The level conversion circuit converts the low voltage pulse generated by the pulse generation module into a high voltage pulse and drives the high voltage switch to realize the high voltage pulse output.

[0063] In some embodiments, the high-voltage pulse generating chip is disposed on the top layer of the circuit, and the high-voltage energy storage element is disposed on the bottom layer of the circuit.

[0064] Specifically, it can be understood that in some embodiments, as shown in FIG6 , all components of the programmable miniaturized high-voltage pulse generating circuit are placed on the top layer of the circuit to provide a flat bottom surface for easy implantation. However, in order to achieve a more miniaturized design, a relatively larger high-voltage capacitor can be placed on the bottom layer of the circuit, while a smaller high-voltage pulse generating chip can still be placed on the top layer of the circuit, so as to achieve a balance and a combination of miniaturization of the circuit and ease of implantation as much as possible. It should be noted that the above embodiment is only a schematic illustration of the present invention, and different arrangements of various components by those skilled in the art are all included in the scope of the present invention, and the present invention is not limited thereto.

[0065] In some embodiments, the high-voltage pulse generation chip integrates multiple programmable low-voltage pulse generation circuits, multiple high-voltage switch modules, and multiple high-voltage power supplies to achieve multi-channel high-voltage pulse output.

[0066] Specifically, it can be understood that a high-voltage pulse generating chip can be designed to integrate multiple programmable low-voltage pulse generating circuits, multiple high-voltage switching modules and multiple high-voltage power supplies to support multi-channel pulse output, and the high-voltage pulse generation of any channel should be included in the scope of the present invention, and the present invention is not limited to this.

[0067] In some embodiments, since implantable medical devices have high requirements for power consumption, the control module can also save power consumption by shutting down various circuit modules when the circuit is not working.

[0068] To better illustrate the technical effects of the embodiments of the present invention, Figure 6 shows the physical design of a programmable miniaturized high-voltage pulse generator circuit. The main components are the chip and high-voltage capacitors, while the peripheral auxiliary circuits primarily include a power interface, a data interface, a power decoupling capacitor, and a charge pump capacitor. In some specific embodiments of the present invention, the main components measure 16mm × 8mm; the chip measures 5mm × 5mm; and a single high-voltage capacitor measures 2.5mm × 2.7mm × 3.2mm. The high-voltage capacitors are Murata's GRM32EC72A106KE05L, which has a 100V withstand voltage and a capacitance of 10uF. In the present design, four high-voltage capacitors are connected in parallel to provide a total capacitance of 40uF. The chip uses a multi-stage charge pump to boost the 5-7.4V input voltage from the power interface to 60V. The on-chip voltage regulator circuit outputs a 50V voltage. This circuit can support pulse outputs with an amplitude of approximately 50V and 100mA, with a maximum pulse width of 2ms. The circuit output capability (voltage, current, maximum pulse width) can be improved by increasing the capacitance of the capacitor, and can be customized according to specific needs. Any parameter setting of high-voltage capacitors and output pulse parameters are included in the scope of protection of this invention.

[0069] It should also be noted that while the embodiments of the present invention provide a fully integrated solution, the arbitrarily splitting of the high-voltage pulse generation chip into multiple chips based on functional modules is also within the scope of protection of the present invention. Decoupling capacitors, data interfaces, power interfaces, and other conventional circuit design features are all included within the scope of the present invention, and parallel alternatives to these conventional features are also included in the scope of the present invention, without limiting the present invention.

[0070] In addition, an embodiment of the present invention further provides an implantable medical device, comprising a device body and a programmable miniaturized high-voltage pulse generating circuit according to an embodiment of the present invention.

[0071] Specifically, it can be understood that by applying the programmable miniaturized high-voltage pulse generating circuit of the embodiment of the present invention to implantable medical devices, on the one hand, high-voltage pulses can be provided for driving the device body to meet the application requirements of medical technical means such as electroporation and ultrasonic imaging; on the other hand, the programmable miniaturized high-voltage pulse generating circuit has the characteristics of integration and miniaturization, which can achieve a good implantation effect, and is therefore in line with the current development trend of miniaturization and refinement of implantable medical devices, which is conducive to the implementation of minimally invasive surgery with less trauma and shorter patient recovery time. At the same time, it can also help reduce the pressure on healthcare infrastructure, that is, it helps to improve the cost-effectiveness of medical institutions and patients.

[0072] Throughout this specification, reference to terms such as "one embodiment," "some embodiments," "illustrative embodiments," "examples," "specific examples," or "some examples" means that a specific feature, structure, material, or characteristic described in conjunction with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

[0073] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and variations may be made to the embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the claims and their equivalents.

Claims

1. A programmable miniaturized high voltage pulse generating circuit, characterized in that: include: A high-voltage pulse generation chip, at least integrated with a programmable low-voltage pulse generation circuit, a high-voltage switch module and a high-voltage power supply, wherein the programmable low-voltage pulse generation circuit is used to generate the required low-voltage pulses through program control, the high-voltage switch module is used to convert the low-voltage pulses into high-voltage pulse outputs, and the high-voltage power supply is used to provide high voltage for the high-voltage switch; A high-voltage energy storage element is connected to the high-voltage power supply and is used to support the instantaneous high-power operation of the high-voltage switch module.

2. The programmable miniaturized high-voltage pulse generating circuit according to claim 1, characterized in that: The high voltage power supply comprises: A boost circuit, connected to the high-voltage energy storage element, for charging the high-voltage energy storage element; A voltage stabilizing circuit is respectively connected to the boost circuit, the high-voltage energy storage element, and the high-voltage switch module. The voltage stabilizing circuit is used to provide a high voltage for the high-voltage switch module. The output voltage of the voltage stabilizing circuit is lower than the minimum voltage value of the high-voltage energy storage element during the discharge cycle.

3. The programmable miniaturized high-voltage pulse generating circuit according to claim 2, characterized in that: The boost circuit comprises: A charge pump, connected to the high-voltage energy storage element and the voltage stabilizing circuit, respectively, for converting a low supply voltage into a high voltage to charge the high-voltage energy storage element; The clock generating circuit is connected to the charge pump and is used to generate a square wave clock signal to drive the charge pump.

4. The programmable miniaturized high-voltage pulse generating circuit according to claim 2, characterized in that: The programmable low voltage pulse generating circuit comprises: A pulse generating module, connected to the high-voltage switch module, for generating a low-voltage pulse with required pulse information through program control, wherein the pulse information includes at least one of frequency, number of pulses, duty cycle, and polarity; The control module is at least connected to the pulse generating module.

5. The programmable miniaturized high-voltage pulse generating circuit according to claim 4, characterized in that: The pulse generation module at least includes any one of a programmable frequency source, a switch, a pulse width modulator, and a polarity controller, all of which are connected to the control module; the programmable frequency source is used to output a square wave signal with a specific frequency and number of cycles; the switch is connected to the programmable frequency source, and the switch is used to control the number of pulses of the square wave signal; The pulse width modulator is connected to the switch, and the pulse width modulator is used to adjust the duty cycle of the square wave signal; the polarity controller is connected to the pulse width modulator and the high-voltage switch module, and the polarity controller is used to control the polarity of the square wave signal.

6. The programmable miniaturized high-voltage pulse generating circuit according to claim 4, characterized in that: The pulse generation module includes a DDS signal generator, and the DDS signal generator is connected to the control module and the high-voltage switch module respectively.

7. The programmable miniaturized high-voltage pulse generating circuit according to claim 4, characterized in that: The high voltage switch module comprises: A level conversion circuit, connected to the pulse generating module and the voltage stabilizing circuit, for converting a low-voltage pulse into a high-voltage pulse; The high-voltage switch is connected to the level conversion circuit and the voltage stabilizing circuit and is used for outputting high-voltage pulses.

8. The programmable miniaturized high-voltage pulse generating circuit according to claim 1, characterized in that: The high-voltage pulse generating chip is arranged on the top layer of the circuit, and the high-voltage energy storage element is arranged on the bottom layer of the circuit.

9. The programmable miniaturized high-voltage pulse generating circuit according to claim 1, characterized in that: The high-voltage pulse generation chip integrates a plurality of the programmable low-voltage pulse generation circuits, a plurality of the high-voltage switch modules and a plurality of the high-voltage power supplies to achieve multi-channel high-voltage pulse output.

10. An implantable medical device, characterized in that: The device comprises a device body and a programmable miniaturized high-voltage pulse generating circuit as claimed in any one of claims 1 to 9.

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