Compounds and methods for reducing PSD3 expression

Abstract

Provided are double-stranded oligonucleotides, polynucleotide conjugates, and compositions and populations comprising the same, as well as methods and uses thereof for reducing the amount or activity of Pleckstrin and Sec7 Domain Containing 3 (PSD3) RNA in a cell or animal, and in certain instances reducing the amount of PSD3 protein in a cell or animal. Such double-stranded oligonucleotides, polynucleotide conjugates, and compositions and populations, methods and uses are useful to treat liver disease, fatty liver disease (FLD), nonalcoholic fatty liver disease (NAFLD), hepatic steatosis, non-alcoholic steatohepatitis (NASH), liver cirrhosis, hepatocellular carcinoma, alcoholic liver disease, alcoholic steatohepatitis (ASH), HCV hepatitis, chronic hepatitis, hereditary hemochromatosis, or primary sclerosing cholangitis.

Description

[0001]COMPOUNDS AND METHODS FOR REDUCING PSD3 EXPRESSION SEQUENCE LISTING The present application is being filed along with a Sequence Listing in electronic format. The Sequence Listing is provided as a file entitled P76363 Sequence Listing, created on September 21, 2023, which is 10.9 MB in size. The information in the electronic format of the sequence listing is incorporated herein by reference in its entirety. Although the sequence listing accompanying this filing identifies each sequence as either “RNA” or “DNA” as required, in reality, those sequences may be modified with any combination of chemical modifications. One of skill in the art will readily appreciate that such designation as “RNA” or “DNA” to describe modified oligonucleotides is, in certain instances, arbitrary. For example, an oligonucleotide comprising a nucleoside comprising a 2’-OH sugar moiety and a thymine base could be described as a DNA having a modified sugar (2’- OH in place of one 2’-H of DNA) or as an RNA having a modified base (thymine (methylated uracil) in place of an uracil of RNA). Accordingly, nucleic acid sequences provided herein, including, but not limited to those in the sequence listing, are intended to encompass nucleic acids containing any combination of natural or modified RNA and / or DNA, unless otherwise stated, including, but not limited to such nucleic acids having modified nucleobases. FIELD Provided are double-stranded oligonucleotides, polynucleotide conjugates, and compositions and populations comprising the same, as well as methods and uses thereof for reducing the amount or activity of Pleckstrin and Sec7 Domain Containing 3 (PSD3) RNA in a cell or animal, and in certain instances reducing the amount of PSD3 protein in a cell or animal. Such double-stranded oligonucleotides, polynucleotide conjugates, and compositions and populations, methods and uses are useful to treat liver disease, fatty liver disease (FLD), nonalcoholic fatty liver disease (NAFLD), hepatic steatosis, non-alcoholic steatohepatitis (NASH), liver cirrhosis, hepatocellular carcinoma, alcoholic liver disease, alcoholic steatohepatitis (ASH), HCV hepatitis, chronic hepatitis, hereditary hemochromatosis, or primary sclerosing cholangitis. BACKGROUND Non-alcoholic fatty liver disease (NAFLD) covers a spectrum of liver disease from steatosis to nonalcoholic steatohepatitis (NASH) and cirrhosis. NAFLD is defined as fat accumulation in the liver exceeding 5% by weight, in the absence of significant alcohol consumption, steatogenic medication, or hereditary disorders (Kotronen et al, Arterioscler Thromb. Vasc. Biol.2008, 28: 27-38). Non-alcoholic steatohepatitis (NASH) is NAFLD with signs of inflammation and hepatic injury. NASH is defined histologically by macrovesicular steatosis, hepatocellular ballooning, and lobular inflammatory infiltrates (Sanyal, Hepatol. Res.2011.41: 670-4). NASH is estimated to affect 2-3% of the general population. In the presence of other pathologies, such as obesity or diabetes, the estimated prevalence increases to 7% and 62% respectively (Hashimoto et al, J. Gastroenterol.2011.46(1): 63-69). PSD3 downregulation by antisense oligonucleotides in vivo protects against fatty liver disease in mice fed on a non-alcoholic steatohepatitis-inducing diet (Nature Metabolism 2022, 4: 60-75). SUMMARY The present inventors have surprisingly demonstrated that double-stranded oligonucleotides targeting a particular transcript for PSD3 are capable of significantly reducing the amount or activity of PSD3 RNA in a cell. As such, these oligonucleotides therefore have potential utility in the treatment of diseases associated with PSD3, particularly NAFLD. Accordingly, the present invention provides a double-stranded oligonucleotide comprising an antisense strand comprising a nucleobase sequence that is at least 80% complementary to an equal length portion of a PSD3 nucleic acid having the nucleobase sequence of SEQ ID NO: 1, and a sense strand. The antisense strand may comprise a nucleobase sequence that is at least 80% complementary to an equal length portion within a nucleobase sequence corresponding to nucleobases 1 to 8100, particularly 1 to 600, 1400 to 3500 or 7500 to 8100 of SEQ ID NO: 1. The antisense strand may comprise a nucleobase sequence that is at least 85%, at least 90%, at least 95%, or 100% complementary to said equal length portion within a nucleobase sequence corresponding to nucleobases 1 to 8100, particularly 1 to 600, 1400 to 3500 or 7500 to 8100 of SEQ ID NO: 1. The nucleobase sequence of the antisense strand may comprise or consist of a nucleobase sequence that is at least 85%, at least 90%, at least 95%, or 100% identical to any of SEQ ID NOs: 2, 3, 6, 7, 10, 11, 14, 15, 18, 19, 22, 23, 26, 27, 30, 31, 34, 35, 38, 39, 42, 43, 46, 47, 50, 51, 54, 55, 58, 59, 62, 63, 66, 67, 70, 71, 74, 75, 78, 79, 82, 83, 86, 87, 90, 91, 94, 95, 98, 99, 102, 103, 106, 107, 110, 111, 114, 115, 118, 119, 122, 123, 126, 127, 130, 131, 134, 135, 138, 139, 142, 143, 146, 147, 150, 151, 154, 155, 158, 159, 162, 163, 166, 167, 170, 171, 174, 175, 178, 179, 182, 183, 186, 187, 190, 191, 194, 195, 198, 199, 202, 203, 206, 207, 210, 211, 214, 215, 218, 219, 222, 223, 226, 227, 230, 231, 234, 235, 238, 239, 242, 243, 246, 247, 250, 251, 254, 255, 258, 259, 262, 263, 266, 267, 270, 271, 274, 275, 278, 279, 282, 283, 286, 287, 290, 291, 294, 295, 298, 299, 302, 303, 306, 307, 310, 311, 314, 315, 318, 319, 322, 323, 326, 327, 330, 331, 334, 335, 338, 339, 342, 343, 346, 347, 350, 351, 354, 355, 358, 359, 362, 363, 366, 367, 370, 371, 374, 375, 378, 379, 382, 383, 386, 387, 390, 391, 394, 395, 398, 399, 402, 403, 406, 407, 410, 411, 414, 415, 418, 419, 422, 423, 426, 427, 430, 431, 434, 435, 438, 439, 442, 443, 446, 447, 450, 451, 454, 455, 458, 459, 462, 463, 466, 467, 470, 471, 474, 475, 478, 479, 482, 483, 486, 487, 490, 491, 494, 495, 498, 499, 502, 503, 506, 507, 510, 511, 514, 515, 518, 519, 522, 523, 526, 527, 530, 531, 534, 535, 538, 539, 542, 543, 546, 547, 550, 551, 554, 555, 558, 559, 562, 563, 566, 567, 570, 571, 574, 575, 578, 579, 582, 583, 586, 587, 590, 591, 594, 595, 598, 599, 602, 603, 606, 607, 610, 611, 614, 615, 618, 619, 622, 623, 626, 627, 630, 631, 634, 635, 638, 639, 642, 643, 646, 647, 650, 651, 654, 655, 658, 659, 662, 663, 666, 667, 670, 671, 674, 675, 678, 679, 682, 683, 686, 687, 690, 691, 694, 695, 698, 699, 702, 703, 706, 707, 710, 711, 714, 715, 718, 719, 722, 723, 726, 727, 730, 731, 734, 735, 738, 739, 742, 743, 746, 747, 750, 751, 754, 755, 758, 759, 762, 763, 766, 767, 770, 771, 774, 775, 778, 779, 782, 783, 786, 787, 790, 791, 794, 795, 798, 799, 802, 803, 806, 807, 810, 811, 814, 815, 818, 819, 822, 823, 826, 827, 830, 831, 834, 835, 838, 839, 842, 843, 846, 847, 850, 851, 854, 855, 858, 859, 862, 863, 866, 867, 870, 871, 874, 875, 878, 879, 882, 883, 886, 887, 890, 891, 894, 895, 898, 899, 902, 903, 906, 907, 910, 911, 914, 915, 918, 919, 922, 923, 926, 927, 930, 931, 934, 935, 938, 939, 942, 943, 946, 947, 950, 951, 954, 955, 958, 959, 962, 963, 966, 967, 970, 971, 974, 975, 978, 979, 982, 983, 986, 987, 990, 991, 994, 995, 998, 999, 1002, 1003, 1006, 1007, 1010, 1011, 1014, 1015, 1018, 1019, 1022, 1023, 1026, 1027, 1030, 1031, 1034, 1035, 1038, 1039, 1042, 1043, 1046, 1047, 1050, 1051, 1054, 1055, 1058, 1059, 1062, 1063, 1066, 1067, 1070, 1071, 1074, 1075, 1078, 1079, 1082, 1083, 1086, 1087, 1090, 1091, 1094, 1095, 1098, 1099, 1102, 1103, 1106, 1107, 1110, 1111, 1114, 1115, 1118, 1119, 1122, 1123, 1126, 1127, 1130, 1131, 1134, 1135, 1138, 1139, 1142, 1143, 1146, 1147, 1150, 1151, 1154, 1155, 1158, 1159, 1162, 1163, 1166, 1167, 1170, 1171, 1174, 1175, 1178, 1179, 1182, 1183, 1186, 1187, 1190, 1191, 1194, 1195, 1198, 1199, 1202, 1203, 1206, 1207, 1210, 1211, 1214, 1215, 1218, 1219, 1222, 1223, 1226, 1227, 1230, 1231, 1234, 1235, 1238, 1239, 1242, 1243, 1246, 1247, 1250, 1251, 1254, 1255, 1258, 1259, 1262, 1263, 1266, 1267, 1270, 1271, 1274, 1275, 1278, 1279, 1282, 1283, 1286, 1287, 1290, 1291, 1294, 1295, 1298, 1299, 1302, 1303, 1306, 1307, 1310, 1311, 1314, 1315, 1318, 1319, 1322, 1323, 1326, 1327, 1330, 1331, 1334, 1335, 1338, 1339, 1342, 1343, 1346, 1347, 1350, 1351, 1354, 1355, 1358, 1359, 1362, 1363, 1366, 1367, 1370, 1371, 1374, 1375, 1378, 1379, 1382, 1383, 1386, 1387, 1390, 1391, 1394, 1395, 1398, 1399, 1402, 1403, 1406, 1407, 1410, 1411, 1414, 1415, 1418, 1419, 1422, 1423, 1426, 1427, 1430, 1431, 1434, 1435, 1438, 1439, 1442, 1443, 1446, 1447, 1450, 1451, 1454, 1455, 1458, 1459, 1462, 1463, 1466, 1467, 1470, 1471, 1474, 1475, 1478, 1479, 1482, 1483, 1486, 1487, 1490, 1491, 1494, 1495, 1498, 1499, 1502, 1503, 1506, 1507, 1510, 1511, 1514, 1515, 1518, 1519, 1522, 1523, 1526, 1527, 1530, 1531, 1534, 1535, 1538, 1539, 1542, 1543, 1546, 1547, 1550, 1551, 1554, 1555, 1558, 1559, 1562, 1563, 1566, 1567, 1570, 1571, 1574, 1575, 1578, 1579, 1582, 1583, 1586, 1587, 1590, 1591, 1594, 1595, 1598, 1599, 1602, 1603, 1606, 1607, 1610, 1611, 1614, 1615, 1618, 1619, 1622, 1623, 1626, 1627, 1630, 1631, 1634, 1635, 1638, 1639, 1642, 1643, 1646, 1647, 1650, 1651, 1654, 1655, 1658, 1659, 1662, 1663, 1666, 1667, 1670, 1671, 1674, 1675, 1678, 1679, 1682, 1683, 1686, 1687, 1690, 1691, 1694, 1695, 1698, 1699, 1702, 1703, 1706, 1707, 1710, 1711, 1714, 1715, 1718, 1719, 1722, 1723, 1726, 1727, 1730, 1731, 1734, 1735, 1738, 1739, 1742, 1743, 1746, 1747, 1750, 1751, 1754, 1755, 1758, 1759, 1762, 1763, 1766, 1767, 1770, 1771, 1774, 1775, 1778, 1779, 1782, 1783, 1786, 1787, 1790, 1791, 1794, 1795, 1798, 1799, 1802, 1803, 1806, 1807, 1810, 1811, 1814, 1815, 1818, 1819, 1822, 1823, 1826, 1827, 1830, 1831, 1834, 1835, 1838, 1839, 1842, 1843, 1846, 1847, 1850, 1851, 1854, 1855, 1858, 1859, 1862, 1863, 1866, 1867, 1870, 1871, 1874, 1875, 1878, 1879, 1882, 1883, 1886, 1887, 1890, 1891, 1894, 1895, 1898, 1899, 1902, 1903, 1906, 1907, 1910, 1911, 1914, 1915, 1918 or 1919, preferably any one of SEQ ID Nos: 34, 35, 54, 55, 58, 59, 142, 143, 158, 159, 250, 251, 262, 263, 282, 283, 286, 287, 390, 391, 398, 399, 426, 427, 470, 471, 478, 479, 494, 495, 502, 503, 522, 523, 566, 567, 574, 575, 586, 587, 606, 607, 618, 619, 626, 627, 654, 655, 666, 667, 678, 679, 694, 695, 698, 699, 722, 723, 730, 731, 742, 743, 778, 779, 802, 803, 822, 823, 830, 831, 842, 843, 846, 847, 858, 859, 862, 863, 866, 867, 870, 871, 874, 875, 878, 879, 886, 887, 906, 907, 914, 915, 946, 947, 954, 955, 970, 971, 978, 979, 1006, 1007, 1018, 1019, 1022, 1023, 1026, 1027, 1034, 1035, 1038, 1039, 1042, 1043, 1058, 1059, 1082, 1083, 1086, 1087, 1102, 1103, 1118, 1119, 1126, 1127, 1142, 1143, 1146, 1147, 1150, 1151, 1154, 1155, 1158, 1159, 1182, 1183, 1186, 1187, 1190, 1191, 1210, 1211, 1214, 1215, 1254, 1255, 1270, 1271, 1274, 1275, 1278, 1279, 1282, 1283, 1294, 1295, 1298, 1299, 1302, 1303, 1310, 1311, 1330, 1331, 1334, 1335, 1346, 1347, 1354, 1355, 1358, 1359, 1362, 1363, 1366, 1367, 1602, 1603, 1614, 1615, 1618, 1619, 1626, 1627, 1630 or 1631. The antisense strand may have a nucleobase sequence comprising at least 15, at least 16, at least 17, at least 18, at least 19, at least 20, at least 21,at least 22, or at least 23 contiguous nucleobases, particularly 19, 20, 21, 22 or 23 contiguous nucleobases of any of the nucleobase sequences of any of SEQ ID NOs: 2, 3, 6, 7, 10, 11, 14, 15, 18, 19, 22, 23, 26, 27, 30, 31, 34, 35, 38, 39, 42, 43, 46, 47, 50, 51, 54, 55, 58, 59, 62, 63, 66, 67, 70, 71, 74, 75, 78, 79, 82, 83, 86, 87, 90, 91, 94, 95, 98, 99, 102, 103, 106, 107, 110, 111, 114, 115, 118, 119, 122, 123, 126, 127, 130, 131, 134, 135, 138, 139, 142, 143, 146, 147, 150, 151, 154, 155, 158, 159, 162, 163, 166, 167, 170, 171, 174, 175, 178, 179, 182, 183, 186, 187, 190, 191, 194, 195, 198, 199, 202, 203, 206, 207, 210, 211, 214, 215, 218, 219, 222, 223, 226, 227, 230, 231, 234, 235, 238, 239, 242, 243, 246, 247, 250, 251, 254, 255, 258, 259, 262, 263, 266, 267, 270, 271, 274, 275, 278, 279, 282, 283, 286, 287, 290, 291, 294, 295, 298, 299, 302, 303, 306, 307, 310, 311, 314, 315, 318, 319, 322, 323, 326, 327, 330, 331, 334, 335, 338, 339, 342, 343, 346, 347, 350, 351, 354, 355, 358, 359, 362, 363, 366, 367, 370, 371, 374, 375, 378, 379, 382, 383, 386, 387, 390, 391, 394, 395, 398, 399, 402, 403, 406, 407, 410, 411, 414, 415, 418, 419, 422, 423, 426, 427, 430, 431, 434, 435, 438, 439, 442, 443, 446, 447, 450, 451, 454, 455, 458, 459, 462, 463, 466, 467, 470, 471, 474, 475, 478, 479, 482, 483, 486, 487, 490, 491, 494, 495, 498, 499, 502, 503, 506, 507, 510, 511, 514, 515, 518, 519, 522, 523, 526, 527, 530, 531, 534, 535, 538, 539, 542, 543, 546, 547, 550, 551, 554, 555, 558, 559, 562, 563, 566, 567, 570, 571, 574, 575, 578, 579, 582, 583, 586, 587, 590, 591, 594, 595, 598, 599, 602, 603, 606, 607, 610, 611, 614, 615, 618, 619, 622, 623, 626, 627, 630, 631, 634, 635, 638, 639, 642, 643, 646, 647, 650, 651, 654, 655, 658, 659, 662, 663, 666, 667, 670, 671, 674, 675, 678, 679, 682, 683, 686, 687, 690, 691, 694, 695, 698, 699, 702, 703, 706, 707, 710, 711, 714, 715, 718, 719, 722, 723, 726, 727, 730, 731, 734, 735, 738, 739, 742, 743, 746, 747, 750, 751, 754, 755, 758, 759, 762, 763, 766, 767, 770, 771, 774, 775, 778, 779, 782, 783, 786, 787, 790, 791, 794, 795, 798, 799, 802, 803, 806, 807, 810, 811, 814, 815, 818, 819, 822, 823, 826, 827, 830, 831, 834, 835, 838, 839, 842, 843, 846, 847, 850, 851, 854, 855, 858, 859, 862, 863, 866, 867, 870, 871, 874, 875, 878, 879, 882, 883, 886, 887, 890, 891, 894, 895, 898, 899, 902, 903, 906, 907, 910, 911, 914, 915, 918, 919, 922, 923, 926, 927, 930, 931, 934, 935, 938, 939, 942, 943, 946, 947, 950, 951, 954, 955, 958, 959, 962, 963, 966, 967, 970, 971, 974, 975, 978, 979, 982, 983, 986, 987, 990, 991, 994, 995, 998, 999, 1002, 1003, 1006, 1007, 1011, 1014, 1015, 1018, 1019, 1022, 1023, 1026, 1027, 1030, 1031, 1034, 1035, 1038, 1039, 1042, 1043, 1046, 1047, 1050, 1051, 1054, 1055, 1058, 1059, 1062, 1063, 1066, 1067, 1070, 1071, 1074, 1075, 1078, 1079, 1082, 1083, 1086, 1087, 1090, 1091, 1094, 1095, 1098, 1099, 1102, 1103, 1106, 1107, 1110, 1111, 1114, 1115, 1118, 1119, 1122, 1123, 1126, 1127, 1130, 1131, 1134, 1135, 1138, 1139, 1142, 1143, 1146, 1147, 1150, 1151, 1154, 1155, 1158, 1159, 1162, 1163, 1166, 1167, 1170, 1171, 1174, 1175, 1178, 1179, 1182, 1183, 1186, 1187, 1190, 1191, 1194, 1195, 1198, 1199, 1202, 1203, 1206, 1207, 1210, 1211, 1214, 1215, 1218, 1219, 1222, 1223, 1226, 1227, 1230, 1231, 1234, 1235, 1238, 1239, 1242, 1243, 1246, 1247, 1250, 1251, 1254, 1255, 1258, 1259, 1262, 1263, 1266, 1267, 1270, 1271, 1274, 1275, 1278, 1279, 1282, 1283, 1286, 1287, 1290, 1291, 1294, 1295, 1298, 1299, 1302, 1303, 1306, 1307, 1310, 1311, 1314, 1315, 1318, 1319, 1322, 1323, 1326, 1327, 1330, 1331, 1334, 1335, 1338, 1339, 1342, 1343, 1346, 1347, 1350, 1351, 1354, 1355, 1358, 1359, 1362, 1363, 1366, 1367, 1370, 1371, 1374, 1375, 1378, 1379, 1382, 1383, 1386, 1387, 1390, 1391, 1394, 1395, 1398, 1399, 1402, 1403, 1406, 1407, 1410, 1411, 1414, 1415, 1418, 1419, 1422, 1423, 1426, 1427, 1430, 1431, 1434, 1435, 1438, 1439, 1442, 1443, 1446, 1447, 1450, 1451, 1454, 1455, 1458, 1459, 1462, 1463, 1466, 1467, 1470, 1471, 1474, 1475, 1478, 1479, 1482, 1483, 1486, 1487, 1490, 1491, 1494, 1495, 1498, 1499, 1502, 1503, 1506, 1507, 1510, 1511, 1514, 1515, 1518, 1519, 1522, 1523, 1526, 1527, 1530, 1531, 1534, 1535, 1538, 1539, 1542, 1543, 1546, 1547, 1550, 1551, 1554, 1555, 1558, 1559, 1562, 1563, 1566, 1567, 1570, 1571, 1574, 1575, 1578, 1579, 1582, 1583, 1586, 1587, 1590, 1591, 1594, 1595, 1598, 1599, 1602, 1603, 1606, 1607, 1610, 1611, 1614, 1615, 1618, 1619, 1622, 1623, 1626, 1627, 1630, 1631, 1634, 1635, 1638, 1639, 1642, 1643, 1646, 1647, 1650, 1651, 1654, 1655, 1658, 1659, 1662, 1663, 1666, 1667, 1670, 1671, 1674, 1675, 1678, 1679, 1682, 1683, 1686, 1687, 1690, 1691, 1694, 1695, 1698, 1699, 1702, 1703, 1706, 1707, 1710, 1711, 1714, 1715, 1718, 1719, 1722, 1723, 1726, 1727, 1730, 1731, 1734, 1735, 1738, 1739, 1742, 1743, 1746, 1747, 1750, 1751, 1754, 1755, 1758, 1759, 1762, 1763, 1766, 1767, 1770, 1771, 1774, 1775, 1778, 1779, 1782, 1783, 1786, 1787, 1790, 1791, 1794, 1795, 1798, 1799, 1802, 1803, 1806, 1807, 1810, 1811, 1814, 1815, 1818, 1819, 1822, 1823, 1826, 1827, 1830, 1831, 1834, 1835, 1838, 1839, 1842, 1843, 1846, 1847, 1850, 1851, 1854, 1855, 1858, 1859, 1862, 1863, 1866, 1867, 1870, 1871, 1874, 1875, 1878, 1879, 1882, 1883, 1886, 1887, 1890, 1891, 1894, 1895, 1898, 1899, 1902, 1903, 1906, 1907, 1910, 1911, 1914, 1915, 1918 or 1919, preferably any one of SEQ ID Nos: 34, 35, 54, 55, 58, 59, 142, 143, 158, 159, 250, 251, 262, 263, 282, 283, 286, 287, 390, 391, 398, 399, 426, 427, 470, 471, 478, 479, 494, 495, 502, 503, 522, 523, 566, 567, 574, 575, 586, 587, 606, 607, 618, 619, 626, 627, 654, 655, 666, 667, 678, 679, 694, 695, 698, 699, 722, 723, 730, 731, 742, 743, 778, 779, 802, 803, 822, 823, 830, 831, 842, 843, 846, 847, 858, 859, 862, 863, 866, 867, 870, 871, 874, 875, 878, 879, 886, 887, 906, 907, 914, 915, 946, 947, 954, 955, 970, 971, 978, 979, 1006, 1007, 1018, 1019, 1022, 1023, 1026, 1027, 1034, 1035, 1038, 1039, 1042, 1043, 1058, 1059, 1082, 1083, 1086, 1087, 1102, 1103, 1118, 1119, 1126, 1127, 1142, 1143, 1146, 1147, 1150, 1151, 1154, 1155, 1158, 1159, 1182, 1183, 1186, 1187, 1190, 1191, 1210, 1211, 1214, 1215, 1254, 1255, 1270, 1271, 1274, 1275, 1278, 1279, 1282, 1283, 1294, 1295, 1298, 1299, 1302, 1303, 1310, 1311, 1330, 1331, 1334, 1335, 1346, 1347, 1354, 1355, 1358, 1359, 1362, 1363, 1366, 1367, 1602, 1603, 1614, 1615, 1618, 1619, 1626, 1627, 1630 or 1631. The nucleobase sequence of the antisense strand may comprise the nucleobase sequence of any of SEQ ID NOs: 2, 3, 6, 7, 10, 11, 14, 15, 18, 19, 22, 23, 26, 27, 30, 31, 34, 35, 38, 39, 42, 43, 46, 47, 50, 51, 54, 55, 58, 59, 62, 63, 66, 67, 70, 71, 74, 75, 78, 79, 82, 83, 86, 87, 90, 91, 94, 95, 98, 99, 102, 103, 106, 107, 110, 111, 114, 115, 118, 119, 122, 123, 126, 127, 130, 131, 134, 135, 138, 139, 142, 143, 146, 147, 150, 151, 154, 155, 158, 159, 162, 163, 166, 167, 170, 171, 174, 175, 178, 179, 182, 183, 186, 187, 190, 191, 194, 195, 198, 199, 202, 203, 206, 207, 210, 211, 214, 215, 218, 219, 222, 223, 226, 227, 230, 231, 234, 235, 238, 239, 242, 243, 246, 247, 250, 251, 254, 255, 258, 259, 262, 263, 266, 267, 270, 271, 274, 275, 278, 279, 282, 283, 286, 287, 290, 291, 294, 295, 298, 299, 302, 303, 306, 307, 310, 311, 314, 315, 318, 319, 322, 323, 326, 327, 330, 331, 334, 335, 338, 339, 342, 343, 346, 347, 350, 351, 354, 355, 358, 359, 362, 363, 366, 367, 370, 371, 374, 375, 378, 379, 382, 383, 386, 387, 390, 391, 394, 395, 398, 399, 402, 403, 406, 407, 410, 411, 414, 415, 418, 419, 422, 423, 426, 427, 430, 431, 434, 435, 438, 439, 442, 443, 446, 447, 450, 451, 454, 455, 458, 459, 462, 463, 466, 467, 470, 471, 474, 475, 478, 479, 482, 483, 486, 487, 490, 491, 494, 495, 498, 499, 502, 503, 506, 507, 510, 511, 514, 515, 518, 519, 522, 523, 526, 527, 530, 531, 534, 535, 538, 539, 542, 543, 546, 547, 550, 551, 554, 555, 558, 559, 562, 563, 566, 567, 570, 571, 574, 575, 578, 579, 582, 583, 586, 587, 590, 591, 594, 595, 598, 599, 602, 603, 606, 607, 610, 611, 614, 615, 618, 619, 622, 623, 626, 627, 630, 631, 634, 635, 638, 639, 642, 643, 646, 647, 650, 651, 654, 655, 658, 659, 662, 663, 666, 667, 670, 671, 674, 675, 678, 679, 682, 683, 686, 687, 690, 691, 694, 695, 698, 699, 702, 703, 706, 707, 710, 711, 714, 715, 718, 719, 722, 723, 726, 727, 730, 731, 734, 735, 738, 739, 742, 743, 746, 747, 750, 751, 754, 755, 758, 759, 762, 763, 766, 767, 770, 771, 774, 775, 778, 779, 782, 783, 786, 787, 790, 791, 794, 795, 798, 799, 802, 803, 806, 807, 810, 811, 814, 815, 818, 819, 822, 823, 826, 827, 830, 831, 834, 835, 838, 839, 842, 843, 846, 847, 850, 851, 854, 855, 858, 859, 862, 863, 866, 867, 870, 871, 874, 875, 878, 879, 882, 883, 886, 887, 890, 891, 894, 895, 898, 899, 902, 903, 906, 907, 910, 911, 914, 915, 918, 919, 922, 923, 926, 927, 930, 931, 934, 935, 938, 939, 942, 943, 946, 947, 950, 951, 954, 955, 958, 959, 962, 963, 966, 967, 970, 971, 974, 975, 978, 979, 982, 983, 986, 987, 990, 991, 994, 995, 998, 999, 1002, 1003, 1006, 1007, 1010, 1011, 1014, 1015, 1018, 1019, 1022, 1023, 1026, 1027, 1030, 1031, 1034, 1035, 1038, 1039, 1042, 1043, 1046, 1047, 1050, 1051, 1054, 1055, 1058, 1059, 1062, 1063, 1066, 1067, 1070, 1071, 1074, 1075, 1078, 1079, 1082, 1083, 1086, 1087, 1090, 1091, 1094, 1095, 1098, 1099, 1102, 1103, 1106, 1107, 1110, 1111, 1114, 1115, 1118, 1119, 1122, 1123, 1126, 1127, 1130, 1131, 1134, 1135, 1138, 1139, 1142, 1143, 1146, 1147, 1150, 1151, 1154, 1155, 1158, 1159, 1162, 1163, 1166, 1167, 1170, 1171, 1174, 1175, 1178, 1179, 1182, 1183, 1186, 1187, 1190, 1191, 1194, 1195, 1198, 1199, 1202, 1203, 1206, 1207, 1210, 1211, 1214, 1215, 1218, 1219, 1222, 1223, 1226, 1227, 1230, 1231, 1234, 1235, 1238, 1239, 1242, 1243, 1246, 1262, 1263, 1266, 1267, 1270, 1271, 1274, 1275, 1278, 1279, 1282, 1283, 1286, 1287, 1290, 1291, 1294, 1295, 1298, 1299, 1302, 1303, 1306, 1307, 1310, 1311, 1314, 1315, 1318, 1319, 1322, 1323, 1326, 1327, 1330, 1331, 1334, 1335, 1338, 1339, 1342, 1343, 1346, 1347, 1350, 1351, 1354, 1355, 1358, 1359, 1362, 1363, 1366, 1367, 1370, 1371, 1374, 1375, 1378, 1379, 1382, 1383, 1386, 1387, 1390, 1391, 1394, 1395, 1398, 1399, 1402, 1403, 1406, 1407, 1410, 1411, 1414, 1415, 1418, 1419, 1422, 1423, 1426, 1427, 1430, 1431, 1434, 1435, 1438, 1439, 1442, 1443, 1446, 1447, 1450, 1451, 1454, 1455, 1458, 1459, 1462, 1463, 1466, 1467, 1470, 1471, 1474, 1475, 1478, 1479, 1482, 1483, 1486, 1487, 1490, 1491, 1494, 1495, 1498, 1499, 1502, 1503, 1506, 1507, 1510, 1511, 1514, 1515, 1518, 1519, 1522, 1523, 1526, 1527, 1530, 1531, 1534, 1535, 1538, 1539, 1542, 1543, 1546, 1547, 1550, 1551, 1554, 1555, 1558, 1559, 1562, 1563, 1566, 1567, 1570, 1571, 1574, 1575, 1578, 1579, 1582, 1583, 1586, 1587, 1590, 1591, 1594, 1595, 1598, 1599, 1602, 1603, 1606, 1607, 1610, 1611, 1614, 1615, 1618, 1619, 1622, 1623, 1626, 1627, 1630, 1631, 1634, 1635, 1638, 1639, 1642, 1643, 1646, 1647, 1650, 1651, 1654, 1655, 1658, 1659, 1662, 1663, 1666, 1667, 1670, 1671, 1674, 1675, 1678, 1679, 1682, 1683, 1686, 1687, 1690, 1691, 1694, 1695, 1698, 1699, 1702, 1703, 1706, 1707, 1710, 1711, 1714, 1715, 1718, 1719, 1722, 1723, 1726, 1727, 1730, 1731, 1734, 1735, 1738, 1739, 1742, 1743, 1746, 1747, 1750, 1751, 1754, 1755, 1758, 1759, 1762, 1763, 1766, 1767, 1770, 1771, 1774, 1775, 1778, 1779, 1782, 1783, 1786, 1787, 1790, 1791, 1794, 1795, 1798, 1799, 1802, 1803, 1806, 1807, 1810, 1811, 1814, 1815, 1818, 1819, 1822, 1823, 1826, 1827, 1830, 1831, 1834, 1835, 1838, 1839, 1842, 1843, 1846, 1847, 1850, 1851, 1854, 1855, 1858, 1859, 1862, 1863, 1866, 1867, 1870, 1871, 1874, 1875, 1878, 1879, 1882, 1883, 1886, 1887, 1890, 1891, 1894, 1895, 1898, 1899, 1902, 1903, 1906, 1907, 1910, 1911, 1914, 1915, 1918 or 1919, preferably any one of SEQ ID Nos: 34, 35, 54, 55, 58, 59, 142, 143, 158, 159, 250, 251, 262, 263, 282, 283, 286, 287, 390, 391, 398, 399, 426, 427, 470, 471, 478, 479, 494, 495, 502, 503, 522, 523, 566, 567, 574, 575, 586, 587, 606, 607, 618, 619, 626, 627, 654, 655, 666, 667, 678, 679, 694, 695, 698, 699, 722, 723, 730, 731, 742, 743, 778, 779, 802, 803, 822, 823, 830, 831, 842, 843, 846, 847, 858, 859, 862, 863, 866, 867, 870, 871, 874, 875, 878, 879, 886, 887, 906, 907, 914, 915, 946, 947, 954, 955, 970, 971, 978, 979, 1006, 1007, 1018, 1019, 1022, 1023, 1026, 1027, 1034, 1035, 1038, 1039, 1042, 1043, 1058, 1059, 1082, 1083, 1086, 1087, 1102, 1103, 1118, 1119, 1126, 1127, 1142, 1143, 1146, 1147, 1150, 1151, 1154, 1155, 1158, 1159, 1182, 1183, 1186, 1187, 1190, 1191, 1210, 1211, 1214, 1215, 1254, 1255, 1270, 1271, 1274, 1275, 1278, 1279, 1282, 1283, 1294, 1295, 1298, 1299, 1302, 1303, 1310, 1311, 1330, 1331, 1334, 1335, 1346, 1347, 1354, 1355, 1358, 1359, 1362, 1363, 1366, 1367, 1602, 1603, 1614, 1615, 1618, 1619, 1626, 1627, 1630 or 1631. The nucleobase sequence of the antisense strand may consist of the nucleobase sequence of any of SEQ ID NOs: 2, 3, 6, 7, 10, 11, 14, 15, 18, 19, 22, 23, 26, 27, 30, 31, 34, 35, 38, 39, 42, 43, 46, 47, 50, 51, 54, 55, 58, 59, 62, 63, 66, 67, 70, 71, 74, 75, 78, 79, 82, 83, 86, 87, 90, 91, 94, 95, 98, 99, 102, 103, 106, 107, 110, 111, 114, 115, 118, 119, 122, 123, 126, 127, 130, 131, 134, 135, 138, 139, 142, 143, 146, 147, 150, 151, 154, 155, 158, 159, 162, 163, 166, 167, 170, 171, 174, 175, 178, 179, 182, 183, 186, 187, 190, 191, 194, 195, 198, 199, 202, 203, 206, 207, 210, 211, 214, 215, 218, 219, 222, 223, 226, 227, 230, 231, 234, 235, 238, 239, 242, 243, 246, 247, 250, 251, 254, 255, 258, 259, 262, 263, 266, 267, 270, 271, 274, 275, 278, 279, 282, 283, 286, 287, 290, 291, 294, 295, 298, 299, 302, 303, 306, 307, 310, 311, 314, 315, 318, 319, 322, 323, 326, 327, 330, 331, 334, 335, 338, 339, 342, 343, 346, 347, 350, 351, 354, 355, 358, 359, 362, 363, 366, 367, 370, 371, 374, 375, 378, 379, 382, 383, 386, 387, 390, 391, 394, 395, 398, 399, 402, 403, 406, 407, 410, 411, 414, 415, 418, 419, 422, 423, 426, 427, 430, 431, 434, 435, 438, 439, 442, 443, 446, 447, 450, 451, 454, 455, 458, 459, 462, 463, 466, 467, 470, 471, 474, 475, 478, 479, 482, 483, 486, 487, 490, 491, 494, 495, 498, 499, 502, 503, 506, 507, 510, 511, 514, 515, 518, 519, 522, 523, 526, 527, 530, 531, 534, 535, 538, 539, 542, 543, 546, 547, 550, 551, 554, 555, 558, 559, 562, 563, 566, 567, 570, 571, 574, 575, 578, 579, 582, 583, 586, 587, 590, 591, 594, 595, 598, 599, 602, 603, 606, 607, 610, 611, 614, 615, 618, 619, 622, 623, 626, 627, 630, 631, 634, 635, 638, 639, 642, 643, 646, 647, 650, 651, 654, 655, 658, 659, 662, 663, 666, 667, 670, 671, 674, 675, 678, 679, 682, 683, 686, 687, 690, 691, 694, 695, 698, 699, 702, 703, 706, 707, 710, 711, 714, 715, 718, 719, 722, 723, 726, 727, 730, 731, 734, 735, 738, 739, 742, 743, 746, 747, 750, 751, 754, 755, 758, 759, 762, 763, 766, 767, 770, 771, 774, 775, 778, 779, 782, 783, 786, 787, 790, 791, 794, 795, 798, 799, 802, 803, 806, 807, 810, 811, 814, 815, 818, 819, 822, 823, 826, 827, 830, 831, 834, 835, 838, 839, 842, 843, 846, 847, 850, 851, 854, 855, 858, 859, 862, 863, 866, 867, 870, 871, 874, 875, 878, 879, 882, 883, 886, 887, 890, 891, 894, 895, 898, 899, 902, 903, 906, 907, 910, 911, 914, 915, 918, 919, 922, 923, 926, 927, 930, 931, 934, 935, 938, 939, 942, 943, 946, 947, 950, 951, 954, 955, 958, 959, 962, 963, 966, 967, 970, 971, 974, 975, 978, 979, 982, 983, 986, 987, 990, 991, 994, 995, 998, 999, 1002, 1003, 1006, 1007, 1010, 1011, 1014, 1015, 1018, 1019, 1022, 1023, 1026, 1027, 1030, 1031, 1034, 1035, 1038, 1039, 1042, 1043, 1046, 1047, 1050, 1051, 1054, 1055, 1058, 1059, 1062, 1063, 1066, 1067, 1070, 1071, 1074, 1075, 1078, 1079, 1082, 1083, 1086, 1087, 1090, 1091, 1094, 1095, 1098, 1099, 1102, 1103, 1106, 1107, 1110, 1111, 1114, 1115, 1118, 1119, 1122, 1123, 1126, 1127, 1130, 1131, 1134, 1135, 1138, 1139, 1142, 1143, 1146, 1147, 1150, 1151, 1154, 1155, 1158, 1159, 1162, 1163, 1166, 1167, 1170, 1171, 1174, 1175, 1178, 1179, 1182, 1183, 1186, 1187, 1190, 1191, 1194, 1195, 1198, 1199, 1202, 1203, 1206, 1207, 1210, 1211, 1214, 1215, 1218, 1219, 1222, 1223, 1226, 1227, 1230, 1231, 1234, 1235, 1238, 1239, 1242, 1243, 1246, 1247, 1250, 1251, 1254, 1255, 1258, 1259, 1262, 1263, 1266, 1267, 1270, 1271, 1274, 1275, 1278, 1279, 1282, 1283, 1286, 1287, 1290, 1291, 1294, 1295, 1298, 1299, 1302, 1303, 1306, 1307, 1310, 1311, 1314, 1315, 1318, 1319, 1322, 1323, 1326, 1327, 1330, 1331, 1334, 1335, 1338, 1339, 1342, 1343, 1346, 1347, 1350, 1351, 1354, 1355, 1358, 1359, 1362, 1363, 1366, 1367, 1370, 1371, 1374, 1375, 1378, 1379, 1382, 1383, 1386, 1387, 1390, 1391, 1394, 1395, 1398, 1399, 1402, 1403, 1406, 1407, 1410, 1411, 1414, 1415, 1418, 1419, 1422, 1423, 1426, 1427, 1430, 1431, 1434, 1435, 1438, 1439, 1442, 1443, 1446, 1447, 1450, 1451, 1454, 1455, 1458, 1459, 1462, 1463, 1466, 1467, 1470, 1471, 1474, 1475, 1478, 1479, 1482, 1483, 1486, 1487, 1490, 1491, 1494, 1495, 1498, 1499, 1502, 1503, 1506, 1507, 1510, 1511, 1514, 1515, 1518, 1519, 1522, 1523, 1526, 1527, 1530, 1531, 1534, 1535, 1538, 1539, 1542, 1543, 1546, 1547, 1550, 1551, 1554, 1555, 1558, 1559, 1562, 1563, 1566, 1567, 1570, 1571, 1574, 1575, 1578, 1579, 1582, 1583, 1586, 1587, 1590, 1591, 1594, 1595, 1598, 1599, 1602, 1603, 1606, 1607, 1610, 1611, 1614, 1615, 1618, 1619, 1622, 1623, 1626, 1627, 1630, 1631, 1634, 1635, 1638, 1639, 1642, 1643, 1646, 1647, 1650, 1651, 1654, 1655, 1658, 1659, 1662, 1663, 1666, 1667, 1670, 1671, 1674, 1675, 1678, 1679, 1682, 1683, 1686, 1687, 1690, 1691, 1694, 1695, 1698, 1699, 1702, 1703, 1706, 1707, 1710, 1711, 1714, 1715, 1718, 1719, 1722, 1723, 1726, 1727, 1730, 1731, 1734, 1735, 1738, 1739, 1742, 1743, 1746, 1747, 1750, 1751, 1754, 1755, 1758, 1759, 1762, 1763, 1766, 1767, 1770, 1771, 1774, 1775, 1778, 1779, 1782, 1783, 1786, 1787, 1790, 1791, 1794, 1795, 1798, 1799, 1802, 1803, 1806, 1807, 1810, 1811, 1814, 1815, 1818, 1819, 1822, 1823, 1826, 1827, 1830, 1831, 1834, 1835, 1838, 1839, 1842, 1843, 1846, 1847, 1850, 1851, 1854, 1855, 1858, 1859, 1862, 1863, 1866, 1867, 1870, 1871, 1874, 1875, 1878, 1879, 1882, 1883, 1886, 1887, 1890, 1891, 1894, 1895, 1898, 1899, 1902, 1903, 1906, 1907, 1910, 1911, 1914, 1915, 1918 or 1919, preferably any one of SEQ ID Nos: 34, 35, 54, 55, 58, 59, 142, 143, 158, 159, 250, 251, 262, 263, 282, 283, 286, 287, 390, 391, 398, 399, 426, 427, 470, 471, 478, 479, 494, 495, 502, 503, 522, 523, 566, 567, 574, 575, 586, 587, 606, 607, 618, 619, 626, 627, 654, 655, 666, 667, 678, 679, 694, 695, 698, 699, 722, 723, 730, 731, 742, 743, 778, 779, 802, 803, 822, 823, 830, 831, 842, 843, 846, 847, 858, 859, 862, 863, 866, 867, 870, 871, 874, 875, 878, 879, 886, 887, 906, 907, 914, 915, 946, 947, 954, 955, 970, 971, 978, 979, 1006, 1007, 1018, 1019, 1022, 1023, 1026, 1027, 1034, 1035, 1038, 1039, 1042, 1043, 1058, 1059, 1082, 1083, 1086, 1087, 1102, 1103, 1118, 1119, 1126, 1127, 1142, 1143, 1146, 1147, 1150, 1151, 1154, 1155, 1158, 1159, 1182, 1183, 1186, 1187, 1190, 1191, 1210, 1211, 1214, 1215, 1254, 1255, 1270, 1271, 1274, 1275, 1278, 1279, 1282, 1283, 1294, 1295, 1298, 1299, 1302, 1303, 1310, 1311, 1330, 1331, 1334, 1335, 1346, 1347, 1354, 1355, 1358, 1359, 1362, 1363, 1366, 1367, 1602, 1603, 1614, 1615, 1618, 1619, 1626, 1627, 1630 or 1631. The sense strand may comprise a nucleobase sequence that is at least 80% identical to said equal length portion within a nucleobase sequence corresponding to nucleobases 1 to 8100, particularly 1 to 600, 1400 to 3500 or 7500 to 8100 of SEQ ID NO: 1. The sense strand may comprise a nucleobase sequence that is at least 85%, at least 90%, at least 95%, or 100% identical to said equal length portion within a nucleobase sequence corresponding to nucleobases 1 to 8100, particularly 1 to 600, 1400 to 3500 or 7500 to 8100 of SEQ ID NO: 1. The nucleobase sequence of the sense strand may comprise or consist of a nucleobase sequence that is at least 85%, at least 90%, at least 95%, or 100% identical to any of SEQ ID NOs: 4, 5, 8, 9, 12, 13, 16, 17, 20, 21, 24, 25, 28, 29, 32, 33, 36, 37, 40, 41, 44, 45, 48, 49, 52, 53, 56, 57, 60, 61, 64, 65, 68, 69, 72, 73, 76, 77, 80, 81, 84, 85, 88, 89, 92, 93, 96, 97, 100, 101, 104, 105, 108, 109, 112, 113, 116, 117, 120, 121, 124, 125, 128, 129, 132, 133, 136, 137, 140, 141, 144, 145, 148, 149, 152, 153, 156, 157, 160, 161, 164, 165, 168, 169, 172, 173, 176, 177, 180, 181, 184, 185, 188, 189, 192, 193, 196, 197, 200, 201, 204, 205, 208, 209, 212, 213, 216, 217, 220, 221, 224, 225, 228, 229, 232, 233, 236, 237, 240, 241, 244, 245, 248, 249, 252, 253, 256, 257, 260, 261, 264, 265, 268, 269, 272, 273, 276, 277, 280, 281, 284, 285, 288, 289, 292, 293, 296, 297, 300, 301, 304, 305, 308, 309, 312, 313, 316, 317, 320, 321, 324, 325, 328, 329, 332, 333, 336, 337, 340, 341, 344, 345, 348, 349, 352, 353, 356, 357, 360, 361, 364, 365, 368, 369, 372, 373, 376, 377, 380, 381, 384, 385, 388, 389, 392, 393, 396, 397, 400, 401, 404, 405, 408, 409, 412, 413, 416, 417, 420, 421, 424, 425, 428, 429, 432, 433, 436, 437, 440, 441, 444, 445, 448, 449, 452, 453, 456, 457, 460, 461, 464, 465, 468, 469, 472, 473, 476, 477, 480, 481, 484, 485, 488, 489, 492, 493, 496, 497, 500, 501, 504, 505, 508, 509, 512, 513, 516, 517, 520, 521, 524, 525, 528, 529, 532, 533, 536, 537, 540, 541, 544, 545, 548, 549, 552, 553, 556, 557, 560, 561, 564, 565, 568, 569, 572, 573, 576, 577, 580, 581, 584, 585, 588, 589, 592, 593, 596, 597, 600, 601, 604, 605, 608, 609, 612, 613, 616, 617, 620, 621, 624, 625, 628, 629, 632, 633, 636, 637, 640, 641, 644, 645, 648, 649, 652, 653, 656, 657, 660, 661, 664, 665, 668, 669, 672, 673, 676, 677, 680, 681, 684, 685, 688, 689, 692, 693, 696, 697, 700, 701, 704, 705, 708, 709, 712, 713, 716, 717, 720, 721, 724, 725, 728, 729, 732, 733, 736, 737, 740, 741, 744, 745, 748, 749, 752, 753, 756, 757, 760, 761, 764, 765, 768, 769, 772, 773, 776, 777, 780, 781, 784, 785, 788, 789, 792, 793, 796, 797, 800, 801, 804, 805, 808, 809, 812, 813, 816, 817, 820, 821, 824, 825, 828, 829, 832, 833, 836, 837, 840, 841, 844, 845, 848, 849, 852, 853, 856, 857, 860, 861, 864, 865, 868, 869, 872, 873, 876, 877, 880, 881, 884, 885, 888, 889, 892, 893, 896, 897, 900, 901, 904, 905, 908, 909, 912, 913, 916, 917, 920, 921, 924, 925, 928, 929, 932, 933, 936, 937, 940, 941, 944, 945, 948, 949, 952, 953, 956, 957, 960, 961, 964, 965, 968, 969, 972, 973, 976, 977, 980, 981, 984, 985, 988, 989, 992, 993, 996, 997, 1000, 1001, 1004, 1005, 1008, 1009, 1012, 1013, 1016, 1017, 1020, 1021, 1024, 1025, 1028, 1029, 1032, 1033, 1036, 1037, 1040, 1041, 1044, 1045, 1048, 1049, 1052, 1053, 1056, 1057, 1060, 1061, 1064, 1065, 1068, 1069, 1072, 1073, 1076, 1077, 1080, 1081, 1084, 1085, 1088, 1089, 1092, 1093, 1096, 1097, 1100, 1101, 1104, 1105, 1108, 1109, 1112, 1113, 1116, 1117, 1120, 1121, 1124, 1125, 1128, 1129, 1132, 1133, 1136, 1137, 1140, 1141, 1144, 1145, 1148, 1149, 1152, 1153, 1156, 1157, 1160, 1161, 1164, 1165, 1168, 1169, 1172, 1173, 1176, 1177, 1180, 1181, 1184, 1185, 1188, 1189, 1192, 1193, 1196, 1197, 1200, 1201, 1204, 1205, 1208, 1209, 1212, 1213, 1216, 1217, 1220, 1221, 1224, 1225, 1228, 1229, 1232, 1233, 1236, 1237, 1240, 1241, 1244, 1245, 1248, 1249, 1252, 1253, 1256, 1257, 1260, 1261, 1264, 1265, 1268, 1269, 1272, 1273, 1276, 1277, 1280, 1281, 1284, 1285, 1288, 1289, 1292, 1293, 1296, 1297, 1300, 1301, 1304, 1305, 1308, 1309, 1312, 1313, 1316, 1317, 1320, 1321, 1324, 1325, 1328, 1329, 1332, 1333, 1336, 1337, 1340, 1341, 1344, 1345, 1348, 1349, 1352, 1353, 1356, 1357, 1360, 1361, 1364, 1365, 1368, 1369, 1372, 1373, 1376, 1377, 1380, 1381, 1384, 1385, 1388, 1389, 1392, 1393, 1396, 1397, 1400, 1401, 1404, 1405, 1408, 1409, 1412, 1413, 1416, 1417, 1420, 1421, 1424, 1425, 1428, 1429, 1432, 1433, 1436, 1437, 1440, 1441, 1444, 1445, 1448, 1449, 1452, 1453, 1456, 1457, 1460, 1461, 1464, 1465, 1468, 1469, 1472, 1473, 1476, 1477, 1480, 1481, 1484, 1485, 1488, 1489, 1492, 1493, 1496, 1497, 1500, 1501, 1504, 1505, 1508, 1509, 1512, 1513, 1516, 1517, 1520, 1521, 1524, 1525, 1528, 1529, 1532, 1533, 1536, 1537, 1540, 1541, 1544, 1545, 1548, 1549, 1552, 1553, 1556, 1557, 1560, 1561, 1564, 1565, 1568, 1569, 1572, 1573, 1576, 1577, 1580, 1581, 1584, 1585, 1588, 1589, 1592, 1593, 1596, 1597, 1600, 1601, 1604, 1605, 1608, 1609, 1612, 1613, 1616, 1617, 1620, 1621, 1624, 1625, 1628, 1629, 1632, 1633, 1636, 1637, 1640, 1641, 1644, 1645, 1648, 1649, 1652, 1653, 1656, 1657, 1660, 1661, 1664, 1665, 1668, 1669, 1672, 1673, 1676, 1677, 1680, 1681, 1684, 1685, 1688, 1689, 1692, 1693, 1696, 1697, 1700, 1701, 1704, 1705, 1708, 1709, 1712, 1713, 1716, 1717, 1720, 1721, 1724, 1725, 1728, 1729, 1732, 1733, 1736, 1737, 1740, 1741, 1744, 1745, 1748, 1749, 1752, 1753, 1756, 1757, 1760, 1761, 1764, 1765, 1768, 1769, 1772, 1773, 1776, 1777, 1780, 1781, 1784, 1785, 1788, 1789, 1792, 1793, 1796, 1797, 1800, 1801, 1804, 1805, 1808, 1809, 1812, 1813, 1816, 1817, 1820, 1821, 1824, 1825, 1828, 1829, 1832, 1833, 1836, 1837, 1840, 1841, 1844, 1845, 1848, 1849, 1852, 1853, 1856, 1857, 1860, 1861, 1864, 1865, 1868, 1869, 1872, 1873, 1876, 1877, 1880, 1881, 1884, 1885, 1888, 1889, 1892, 1893, 1896, 1897, 1900, 1901, 1904, 1905, 1908, 1909, 1912, 1913, 1916, 1917, 1920 or 1921, preferably any one of SEQ ID Nos: 36, 37, 56, 57, 60, 61, 144, 145, 160, 161, 252, 253, 264, 265, 284, 285, 288, 289, 392, 393, 400, 401, 428, 429, 472, 473, 480, 481, 496, 497, 504, 505, 524, 525, 568, 569, 576, 577, 588, 589, 608, 609, 620, 621, 628, 629, 656, 657, 668, 669, 680, 681, 696, 697, 700, 701, 724, 725, 732, 733, 744, 745, 780, 781, 804, 805, 824, 825, 832, 833, 844, 845, 848, 849, 860, 861, 864, 865, 868, 869, 872, 873, 876, 877, 880, 881, 888, 889, 908, 909, 916, 917, 948, 949, 956, 957, 972, 973, 980, 981, 1008, 1009, 1020, 1021, 1024, 1025, 1028, 1029, 1036, 1037, 1040, 1041, 1044, 1045, 1060, 1061, 1084, 1085, 1088, 1089, 1104, 1105, 1120, 1121, 1128, 1129, 1144, 1145, 1148, 1149, 1152, 1153, 1156, 1157, 1160, 1161, 1184, 1185, 1188, 1189, 1192, 1193, 1212, 1213, 1216, 1217, 1256, 1257, 1272, 1273, 1276, 1277, 1280, 1281, 1284, 1285, 1296, 1297, 1300, 1301, 1304, 1305, 1312, 1313, 1332, 1333, 1336, 1337, 1348, 1349, 1356, 1357, 1360, 1361, 1364, 1365, 1368, 1369, 1604, 1605, 1616, 1617, 1620, 1621, 1628, 1629, 1632 or 1633. The sense strand may have a nucleobase sequence comprising at least 15, at least 16, at least 17, at least 18, at least 19, at least 20 or at least 21 contiguous nucleobases, particularly 19, 20 or 21 contiguous nucleobases of any of the nucleobase sequences of any of SEQ ID NOs: 4, 5, 8, 9, 12, 13, 16, 17, 20, 21, 24, 25, 28, 29, 32, 33, 36, 37, 40, 41, 44, 45, 48, 49, 52, 53, 56, 57, 60, 61, 64, 65, 68, 69, 72, 73, 76, 77, 80, 81, 84, 85, 88, 89, 92, 93, 96, 97, 100, 101, 104, 105, 108, 109, 112, 113, 116, 117, 120, 121, 124, 125, 128, 129, 132, 133, 136, 137, 140, 141, 144, 145, 148, 149, 152, 153, 156, 157, 160, 161, 164, 165, 168, 169, 172, 173, 176, 177, 180, 181, 184, 185, 188, 189, 192, 193, 196, 197, 200, 201, 204, 205, 208, 209, 212, 213, 216, 217, 220, 221, 224, 225, 228, 229, 232, 233, 236, 237, 240, 241, 244, 245, 248, 249, 252, 253, 256, 257, 260, 261, 264, 265, 268, 269, 272, 273, 276, 277, 280, 281, 284, 285, 288, 289, 292, 293, 296, 297, 300, 301, 304, 305, 308, 309, 312, 313, 316, 317, 320, 321, 324, 325, 328, 329, 332, 333, 336, 337, 340, 341, 344, 345, 348, 349, 352, 353, 356, 357, 360, 361, 364, 365, 368, 369, 372, 373, 376, 377, 380, 381, 384, 385, 388, 389, 392, 393, 396, 397, 400, 401, 404, 405, 408, 409, 412, 413, 416, 417, 420, 421, 424, 425, 428, 429, 432, 433, 436, 437, 440, 441, 444, 445, 448, 449, 452, 453, 456, 457, 460, 461, 464, 465, 468, 469, 472, 473, 476, 477, 480, 481, 484, 485, 488, 489, 492, 493, 496, 497, 500, 501, 504, 505, 508, 509, 512, 513, 516, 517, 520, 521, 524, 525, 528, 529, 532, 533, 536, 537, 540, 541, 544, 545, 548, 549, 552, 553, 556, 557, 560, 561, 564, 565, 568, 569, 572, 573, 576, 577, 580, 581, 584, 585, 588, 589, 592, 593, 596, 597, 600, 601, 604, 605, 608, 609, 612, 613, 616, 617, 620, 621, 624, 625, 628, 629, 632, 633, 636, 637, 640, 641, 644, 645, 648, 649, 652, 653, 656, 657, 660, 661, 664, 665, 668, 669, 672, 673, 676, 677, 680, 681, 684, 685, 688, 689, 692, 693, 696, 697, 700, 701, 704, 705, 708, 709, 712, 713, 716, 717, 720, 721, 724, 725, 728, 729, 732, 733, 736, 737, 740, 741, 744, 745, 748, 749, 752, 753, 756, 757, 760, 761, 764, 765, 768, 769, 772, 773, 776, 777, 780, 781, 784, 785, 788, 789, 792, 793, 796, 797, 800, 801, 804, 805, 808, 809, 812, 813, 816, 817, 820, 821, 824, 825, 828, 829, 832, 833, 836, 837, 840, 841, 844, 845, 848, 849, 852, 853, 856, 857, 860, 861, 864, 865, 868, 869, 872, 873, 876, 877, 880, 881, 884, 885, 888, 889, 892, 893, 896, 897, 900, 901, 904, 905, 908, 909, 912, 913, 916, 917, 920, 921, 924, 925, 928, 929, 932, 933, 936, 937, 940, 941, 944, 945, 948, 949, 952, 953, 956, 957, 960, 961, 964, 965, 968, 969, 972, 973, 976, 977, 980, 981, 984, 985, 988, 989, 992, 993, 996, 997, 1000, 1001, 1004, 1005, 1008, 1009, 1012, 1013, 1016, 1017, 1020, 1021, 1024, 1025, 1028, 1029, 1032, 1033, 1036, 1037, 1040, 1041, 1044, 1045, 1048, 1049, 1052, 1053, 1056, 1057, 1060, 1061, 1064, 1065, 1068, 1069, 1072, 1073, 1076, 1077, 1080, 1081, 1084, 1085, 1088, 1089, 1092, 1093, 1096, 1097, 1100, 1101, 1104, 1105, 1108, 1109, 1112, 1113, 1116, 1117, 1120, 1121, 1124, 1125, 1128, 1129, 1132, 1133, 1136, 1137, 1140, 1141, 1144, 1145, 1148, 1149, 1152, 1153, 1156, 1157, 1160, 1161, 1164, 1165, 1168, 1169, 1172, 1173, 1176, 1177, 1180, 1181, 1184, 1185, 1188, 1189, 1192, 1193, 1196, 1197, 1200, 1201, 1204, 1205, 1208, 1209, 1212, 1213, 1216, 1217, 1220, 1221, 1224, 1225, 1228, 1229, 1232, 1233, 1236, 1237, 1240, 1241, 1244, 1245, 1248, 1249, 1252, 1253, 1256, 1257, 1260, 1261, 1264, 1265, 1268, 1269, 1272, 1273, 1276, 1277, 1280, 1281, 1284, 1285, 1288, 1289, 1292, 1293, 1296, 1297, 1300, 1301, 1304, 1305, 1308, 1309, 1312, 1313, 1316, 1317, 1320, 1321, 1324, 1325, 1328, 1329, 1332, 1333, 1336, 1337, 1340, 1341, 1344, 1345, 1348, 1349, 1352, 1353, 1356, 1357, 1360, 1361, 1364, 1365, 1368, 1369, 1372, 1373, 1376, 1377, 1380, 1381, 1384, 1385, 1388, 1389, 1392, 1393, 1396, 1397, 1400, 1401, 1404, 1405, 1408, 1409, 1412, 1413, 1416, 1417, 1420, 1421, 1424, 1425, 1428, 1429, 1432, 1433, 1436, 1437, 1440, 1441, 1444, 1445, 1448, 1449, 1452, 1453, 1456, 1457, 1460, 1461, 1464, 1465, 1468, 1469, 1472, 1473, 1476, 1477, 1480, 1481, 1484, 1485, 1488, 1489, 1492, 1493, 1496, 1497, 1500, 1501, 1504, 1505, 1508, 1509, 1512, 1513, 1516, 1517, 1520, 1521, 1524, 1525, 1528, 1529, 1532, 1533, 1536, 1537, 1540, 1541, 1544, 1545, 1548, 1549, 1552, 1553, 1556, 1557, 1560, 1561, 1564, 1565, 1568, 1569, 1572, 1573, 1576, 1577, 1580, 1581, 1584, 1585, 1588, 1589, 1592, 1593, 1596, 1597, 1600, 1601, 1604, 1605, 1608, 1609, 1612, 1613, 1616, 1617, 1620, 1621, 1624, 1625, 1628, 1629, 1632, 1633, 1636, 1637, 1640, 1641, 1644, 1645, 1648, 1649, 1652, 1653, 1656, 1657, 1660, 1661, 1664, 1665, 1668, 1669, 1672, 1673, 1676, 1677, 1680, 1681, 1684, 1685, 1688, 1689, 1692, 1693, 1696, 1697, 1700, 1701, 1704, 1705, 1708, 1709, 1712, 1713, 1716, 1717, 1720, 1721, 1724, 1725, 1728, 1729, 1732, 1733, 1736, 1737, 1740, 1741, 1744, 1745, 1748, 1749, 1752, 1753, 1756, 1757, 1760, 1761, 1764, 1765, 1768, 1769, 1772, 1773, 1776, 1777, 1780, 1781, 1784, 1785, 1788, 1789, 1792, 1793, 1796, 1797, 1800, 1801, 1804, 1805, 1808, 1809, 1812, 1813, 1816, 1817, 1820, 1821, 1824, 1825, 1828, 1829, 1832, 1833, 1836, 1837, 1840, 1841, 1844, 1845, 1848, 1849, 1852, 1853, 1856, 1857, 1860, 1861, 1864, 1865, 1868, 1869, 1872, 1873, 1876, 1877, 1880, 1881, 1884, 1885, 1888, 1889, 1892, 1893, 1896, 1897, 1900, 1901, 1904, 1905, 1908, 1909, 1912, 1913, 1916, 1917, 1920 or 1921, preferably any one of SEQ ID Nos: 36, 37, 56, 57, 60, 61, 144, 145, 160, 161, 252, 253, 264, 265, 284, 285, 288, 289, 392, 393, 400, 401, 428, 429, 472, 473, 480, 481, 496, 497, 504, 505, 524, 525, 568, 569, 576, 577, 588, 589, 608, 609, 620, 621, 628, 629, 656, 657, 668, 669, 680, 681, 696, 697, 700, 701, 724, 725, 732, 733, 744, 745, 780, 781, 804, 805, 824, 825, 832, 833, 844, 845, 848, 849, 860, 861, 864, 865, 868, 869, 872, 873, 876, 877, 880, 881, 888, 889, 908, 909, 916, 917, 948, 949, 956, 957, 972, 973, 980, 981, 1008, 1009, 1020, 1021, 1024, 1025, 1028, 1029, 1036, 1037, 1040, 1041, 1044, 1045, 1060, 1061, 1084, 1085, 1088, 1089, 1104, 1105, 1120, 1121, 1128, 1129, 1144, 1145, 1148, 1149, 1152, 1153, 1156, 1157, 1160, 1161, 1184, 1185, 1188, 1189, 1192, 1193, 1212, 1213, 1216, 1217, 1256, 1257, 1272, 1273, 1276, 1277, 1280, 1281, 1284, 1285, 1296, 1297, 1300, 1301, 1304, 1305, 1312, 1313, 1332, 1333, 1336, 1337, 1348, 1349, 1356, 1357, 1360, 1361, 1364, 1365, 1368, 1369, 1604, 1605, 1616, 1617, 1620, 1621, 1628, 1629, 1632 or 1633. The nucleobase sequence of the sense strand may comprise the nucleobase sequence of any of SEQ ID NOs: 4, 5, 8, 9, 12, 13, 16, 17, 20, 21, 24, 25, 28, 29, 32, 33, 36, 37, 40, 41, 44, 45, 48, 49, 52, 53, 56, 57, 60, 61, 64, 65, 68, 69, 72, 73, 76, 77, 80, 81, 84, 85, 88, 89, 92, 93, 96, 97, 100, 101, 104, 105, 108, 109, 112, 113, 116, 117, 120, 121, 124, 125, 128, 129, 132, 133, 136, 137, 140, 141, 144, 145, 148, 149, 152, 153, 156, 157, 160, 161, 164, 165, 168, 169, 172, 173, 176, 177, 180, 181, 184, 185, 188, 189, 192, 193, 196, 197, 200, 201, 204, 205, 208, 209, 212, 213, 216, 217, 220, 221, 224, 225, 228, 229, 232, 233, 236, 237, 240, 241, 244, 245, 248, 249, 252, 253, 256, 257, 260, 261, 264, 265, 268, 269, 272, 273, 276, 277, 280, 281, 284, 285, 288, 289, 292, 293, 296, 297, 300, 301, 304, 305, 308, 309, 312, 313, 316, 317, 320, 321, 324, 325, 328, 329, 332, 333, 336, 337, 340, 341, 344, 345, 348, 349, 352, 353, 356, 357, 360, 361, 364, 365, 368, 369, 372, 373, 376, 377, 380, 381, 384, 385, 388, 389, 392, 393, 396, 397, 400, 401, 404, 405, 408, 409, 412, 413, 416, 417, 420, 421, 424, 425, 428, 429, 432, 433, 436, 437, 440, 441, 444, 445, 448, 449, 452, 453, 456, 457, 460, 461, 464, 465, 468, 469, 472, 473, 476, 477, 480, 481, 484, 485, 488, 489, 492, 493, 496, 497, 500, 501, 504, 505, 508, 509, 512, 513, 516, 517, 520, 521, 524, 525, 528, 529, 532, 533, 536, 537, 540, 541, 544, 545, 548, 549, 552, 553, 556, 557, 560, 561, 564, 565, 568, 569, 572, 573, 576, 577, 580, 581, 584, 585, 588, 589, 592, 593, 596, 597, 600, 601, 604, 605, 608, 609, 612, 613, 616, 617, 620, 621, 624, 625, 628, 629, 632, 633, 636, 637, 640, 641, 644, 645, 648, 649, 652, 653, 656, 657, 660, 661, 664, 665, 668, 669, 672, 673, 676, 677, 680, 681, 684, 685, 688, 689, 692, 693, 696, 697, 700, 701, 704, 705, 708, 709, 712, 713, 716, 717, 720, 721, 724, 725, 728, 729, 732, 733, 736, 737, 740, 741, 744, 745, 748, 749, 752, 753, 756, 757, 760, 761, 764, 765, 768, 769, 772, 773, 776, 777, 780, 781, 784, 785, 788, 789, 792, 793, 796, 797, 800, 801, 804, 805, 808, 809, 812, 813, 816, 817, 820, 821, 824, 825, 828, 829, 832, 833, 836, 837, 840, 841, 844, 845, 848, 849, 852, 853, 856, 857, 860, 861, 864, 865, 868, 869, 872, 873, 876, 877, 880, 881, 884, 885, 888, 889, 892, 893, 896, 897, 900, 901, 904, 905, 908, 909, 912, 913, 916, 917, 920, 921, 924, 925, 928, 929, 932, 933, 936, 937, 940, 941, 944, 945, 948, 949, 952, 953, 956, 957, 960, 961, 964, 965, 968, 969, 972, 973, 976, 977, 980, 981, 984, 985, 988, 989, 992, 993, 996, 997, 1000, 1001, 1004, 1005, 1008, 1009, 1012, 1013, 1016, 1017, 1020, 1021, 1024, 1025, 1028, 1029, 1032, 1033, 1036, 1037, 1040, 1041, 1044, 1045, 1048, 1049, 1052, 1053, 1056, 1057, 1060, 1061, 1064, 1065, 1068, 1069, 1072, 1073, 1076, 1077, 1080, 1081, 1084, 1085, 1088, 1089, 1092, 1093, 1096, 1097, 1100, 1101, 1104, 1105, 1108, 1109, 1112, 1113, 1116, 1117, 1120, 1121, 1124, 1125, 1128, 1129, 1132, 1133, 1136, 1137, 1140, 1141, 1144, 1145, 1148, 1149, 1152, 1153, 1156, 1157, 1160, 1161, 1164, 1165, 1168, 1169, 1172, 1173, 1176, 1177, 1180, 1181, 1184, 1185, 1188, 1189, 1192, 1193, 1196, 1197, 1200, 1201, 1204, 1205, 1208, 1209, 1212, 1213, 1216, 1217, 1220, 1221, 1224, 1225, 1228, 1229, 1232, 1233, 1236, 1237, 1240, 1241, 1244, 1245, 1248, 1249, 1252, 1253, 1256, 1257, 1260, 1261, 1264, 1265, 1268, 1269, 1272, 1273, 1276, 1277, 1280, 1281, 1284, 1285, 1288, 1289, 1292, 1293, 1296, 1297, 1300, 1301, 1304, 1305, 1308, 1309, 1312, 1313, 1316, 1317, 1320, 1321, 1324, 1325, 1328, 1329, 1332, 1333, 1336, 1337, 1340, 1341, 1344, 1345, 1348, 1349, 1352, 1353, 1356, 1357, 1360, 1361, 1364, 1365, 1368, 1369, 1372, 1373, 1376, 1377, 1380, 1381, 1384, 1385, 1388, 1389, 1392, 1393, 1396, 1397, 1400, 1401, 1404, 1405, 1408, 1409, 1412, 1413, 1416, 1417, 1420, 1421, 1424, 1425, 1428, 1429, 1432, 1433, 1436, 1437, 1440, 1441, 1444, 1445, 1448, 1449, 1452, 1453, 1456, 1457, 1460, 1461, 1464, 1465, 1468, 1469, 1472, 1473, 1476, 1477, 1480, 1481, 1484, 1485, 1488, 1489, 1492, 1493, 1496, 1497, 1500, 1501, 1504, 1505, 1508, 1509, 1512, 1513, 1516, 1517, 1520, 1521, 1524, 1525, 1528, 1529, 1532, 1533, 1536, 1537, 1540, 1541, 1544, 1545, 1548, 1549, 1552, 1553, 1556, 1557, 1560, 1561, 1564, 1565, 1568, 1569, 1572, 1573, 1576, 1577, 1580, 1581, 1584, 1585, 1588, 1589, 1592, 1593, 1596, 1597, 1600, 1601, 1604, 1605, 1608, 1609, 1612, 1613, 1616, 1617, 1620, 1621, 1624, 1625, 1628, 1629, 1632, 1633, 1636, 1637, 1640, 1641, 1644, 1645, 1648, 1649, 1652, 1653, 1656, 1657, 1660, 1661, 1664, 1665, 1668, 1669, 1672, 1673, 1676, 1677, 1680, 1681, 1684, 1685, 1688, 1689, 1692, 1693, 1696, 1697, 1700, 1701, 1704, 1705, 1708, 1709, 1712, 1713, 1716, 1717, 1720, 1721, 1724, 1725, 1728, 1729, 1732, 1733, 1736, 1737, 1740, 1741, 1744, 1745, 1748, 1749, 1752, 1753, 1756, 1757, 1760, 1761, 1764, 1765, 1768, 1769, 1772, 1773, 1776, 1777, 1780, 1781, 1784, 1785, 1788, 1789, 1792, 1793, 1796, 1797, 1800, 1801, 1804, 1805, 1808, 1809, 1812, 1813, 1816, 1817, 1820, 1821, 1824, 1825, 1828, 1829, 1832, 1833, 1836, 1837, 1840, 1841, 1844, 1845, 1848, 1849, 1852, 1853, 1856, 1857, 1860, 1861, 1864, 1865, 1868, 1869, 1872, 1873, 1876, 1877, 1880, 1881, 1884, 1885, 1888, 1889, 1892, 1893, 1896, 1897, 1900, 1901, 1904, 1905, 1908, 1909, 1912, 1913, 1916, 1917, 1920 or 1921, preferably any one of SEQ ID Nos: 36, 37, 56, 57, 60, 61, 144, 145, 160, 161, 252, 253, 264, 265, 284, 285, 288, 289, 392, 393, 400, 401, 428, 429, 472, 473, 480, 481, 496, 497, 504, 505, 524, 525, 568, 569, 576, 577, 588, 589, 608, 609, 620, 621, 628, 629, 656, 657, 668, 669, 680, 681, 696, 697, 700, 701, 724, 725, 732, 733, 744, 745, 780, 781, 804, 805, 824, 825, 832, 833, 844, 845, 848, 849, 860, 861, 864, 865, 868, 869, 872, 873, 876, 877, 880, 881, 888, 889, 908, 909, 916, 917, 948, 949, 956, 957, 972, 973, 980, 981, 1008, 1009, 1020, 1021, 1024, 1025, 1028, 1029, 1036, 1037, 1040, 1041, 1044, 1045, 1060, 1061, 1084, 1085, 1088, 1089, 1104, 1105, 1120, 1121, 1128, 1129, 1144, 1145, 1148, 1149, 1152, 1153, 1156, 1157, 1160, 1161, 1184, 1185, 1188, 1189, 1192, 1193, 1212, 1213, 1216, 1217, 1256, 1257, 1272, 1273, 1276, 1277, 1280, 1281, 1284, 1285, 1296, 1297, 1300, 1301, 1304, 1305, 1312, 1313, 1332, 1333, 1336, 1337, 1348, 1349, 1356, 1357, 1360, 1361, 1364, 1365, 1368, 1369, 1604, 1605, 1616, 1617, 1620, 1621, 1628, 1629, 1632 or 1633. The nucleobase sequence of the sense strand may consist of the nucleobase sequence of any of SEQ ID NOs: 4, 5, 8, 9, 12, 13, 16, 17, 20, 21, 24, 25, 28, 29, 32, 33, 36, 37, 40, 41, 44, 45, 48, 49, 52, 53, 56, 57, 60, 61, 64, 65, 68, 69, 72, 73, 76, 77, 80, 81, 84, 85, 88, 89, 92, 93, 96, 97, 100, 101, 104, 105, 108, 109, 112, 113, 116, 117, 120, 121, 124, 125, 128, 129, 132, 133, 136, 137, 140, 141, 144, 145, 148, 149, 152, 153, 156, 157, 160, 161, 164, 165, 168, 169, 172, 173, 176, 177, 180, 181, 184, 185, 188, 189, 192, 193, 196, 197, 200, 201, 204, 205, 208, 209, 212, 213, 216, 217, 220, 221, 224, 225, 228, 229, 232, 233, 236, 237, 240, 241, 244, 245, 248, 249, 252, 253, 256, 257, 260, 261, 264, 265, 268, 269, 272, 273, 276, 277, 280, 281, 284, 285, 288, 289, 292, 293, 296, 297, 300, 301, 304, 305, 308, 309, 312, 313, 316, 317, 320, 321, 324, 325, 328, 329, 332, 333, 336, 337, 340, 341, 344, 345, 348, 349, 352, 353, 356, 357, 360, 361, 364, 365, 368, 369, 372, 373, 376, 377, 380, 381, 384, 385, 388, 389, 392, 393, 396, 397, 400, 401, 404, 405, 408, 409, 412, 413, 416, 417, 420, 421, 424, 425, 428, 429, 432, 433, 436, 437, 440, 441, 444, 445, 448, 449, 452, 453, 456, 457, 460, 461, 464, 465, 468, 469, 472, 473, 476, 477, 480, 481, 484, 485, 488, 489, 492, 493, 496, 497, 500, 501, 504, 505, 508, 509, 512, 513, 516, 517, 520, 521, 524, 525, 528, 529, 532, 533, 536, 537, 540, 541, 544, 545, 548, 549, 552, 553, 556, 557, 560, 561, 564, 565, 568, 569, 572, 573, 576, 577, 580, 581, 584, 585, 588, 589, 592, 593, 596, 597, 600, 601, 604, 605, 608, 609, 612, 613, 616, 617, 620, 621, 624, 625, 628, 629, 632, 633, 636, 637, 640, 641, 644, 645, 648, 649, 652, 653, 656, 657, 660, 661, 664, 665, 668, 669, 672, 673, 676, 677, 680, 681, 684, 685, 688, 689, 692, 693, 696, 697, 700, 701, 704, 705, 708, 709, 712, 713, 716, 717, 720, 721, 724, 725, 728, 729, 732, 733, 736, 737, 740, 741, 744, 745, 748, 749, 752, 753, 756, 757, 760, 761, 764, 765, 768, 769, 772, 773, 776, 777, 780, 781, 784, 785, 788, 789, 792, 793, 796, 797, 800, 801, 804, 805, 808, 809, 812, 813, 816, 817, 820, 821, 824, 825, 828, 829, 832, 833, 836, 837, 840, 841, 844, 845, 848, 849, 852, 853, 856, 857, 860, 861, 864, 865, 868, 869, 872, 873, 876, 877, 880, 881, 884, 885, 888, 889, 892, 893, 896, 897, 900, 901, 904, 905, 908, 909, 912, 913, 916, 917, 920, 921, 924, 925, 928, 929, 932, 933, 936, 937, 940, 941, 944, 945, 948, 949, 952, 953, 956, 957, 960, 961, 964, 965, 968, 969, 972, 973, 976, 977, 980, 981, 984, 985, 988, 989, 992, 993, 996, 997, 1000, 1001, 1004, 1005, 1008, 1009, 1012, 1013, 1016, 1017, 1020, 1021, 1024, 1025, 1028, 1029, 1032, 1033, 1036, 1037, 1040, 1041, 1044, 1045, 1048, 1049, 1052, 1053, 1056, 1057, 1060, 1061, 1064, 1065, 1068, 1069, 1072, 1073, 1076, 1077, 1080, 1081, 1084, 1085, 1088, 1089, 1092, 1093, 1096, 1097, 1100, 1101, 1104, 1105, 1108, 1109, 1112, 1113, 1116, 1117, 1120, 1121, 1124, 1125, 1128, 1129, 1132, 1133, 1136, 1137, 1140, 1141, 1144, 1145, 1148, 1149, 1152, 1153, 1156, 1157, 1160, 1161, 1164, 1165, 1168, 1169, 1172, 1173, 1176, 1177, 1180, 1181, 1184, 1185, 1188, 1189, 1192, 1193, 1196, 1197, 1200, 1201, 1204, 1205, 1208, 1209, 1212, 1213, 1216, 1217, 1220, 1221, 1224, 1225, 1228, 1229, 1232, 1233, 1236, 1237, 1240, 1241, 1244, 1245, 1248, 1249, 1252, 1253, 1256, 1257, 1260, 1261, 1264, 1265, 1268, 1269, 1272, 1273, 1276, 1277, 1280, 1281, 1284, 1285, 1288, 1289, 1292, 1293, 1296, 1297, 1300, 1301, 1304, 1305, 1308, 1309, 1312, 1313, 1316, 1317, 1320, 1321, 1324, 1325, 1328, 1329, 1332, 1333, 1336, 1337, 1340, 1341, 1344, 1345, 1348, 1349, 1352, 1353, 1356, 1357, 1360, 1361, 1364, 1365, 1368, 1369, 1372, 1373, 1376, 1377, 1380, 1381, 1384, 1385, 1388, 1389, 1392, 1393, 1396, 1397, 1400, 1401, 1404, 1405, 1408, 1409, 1412, 1413, 1416, 1417, 1420, 1421, 1424, 1425, 1428, 1429, 1432, 1433, 1436, 1437, 1440, 1441, 1444, 1445, 1448, 1449, 1452, 1453, 1456, 1457, 1460, 1461, 1464, 1465, 1468, 1469, 1472, 1473, 1476, 1477, 1480, 1481, 1484, 1485, 1488, 1489, 1492, 1493, 1496, 1497, 1500, 1501, 1504, 1505, 1508, 1509, 1512, 1513, 1516, 1517, 1520, 1521, 1524, 1525, 1528, 1529, 1532, 1533, 1536, 1537, 1540, 1541, 1544, 1545, 1548, 1549, 1552, 1553, 1556, 1557, 1560, 1561, 1564, 1565, 1568, 1569, 1572, 1573, 1576, 1577, 1580, 1581, 1584, 1585, 1588, 1589, 1592, 1593, 1596, 1597, 1600, 1601, 1604, 1605, 1608, 1609, 1612, 1613, 1616, 1617, 1620, 1621, 1624, 1625, 1628, 1629, 1632, 1633, 1636, 1637, 1640, 1641, 1644, 1645, 1648, 1649, 1652, 1653, 1656, 1657, 1660, 1661, 1664, 1665, 1668, 1669, 1672, 1673, 1676, 1677, 1680, 1681, 1684, 1685, 1688, 1689, 1692, 1693, 1696, 1697, 1700, 1701, 1704, 1705, 1708, 1709, 1712, 1713, 1716, 1717, 1720, 1721, 1724, 1725, 1728, 1729, 1732, 1733, 1736, 1737, 1740, 1741, 1744, 1745, 1748, 1749, 1752, 1753, 1756, 1757, 1760, 1761, 1764, 1765, 1768, 1769, 1772, 1773, 1776, 1777, 1780, 1781, 1784, 1785, 1788, 1789, 1792, 1793, 1796, 1797, 1800, 1801, 1804, 1805, 1808, 1809, 1812, 1813, 1816, 1817, 1820, 1821, 1824, 1825, 1828, 1829, 1832, 1833, 1836, 1837, 1840, 1841, 1844, 1845, 1848, 1849, 1852, 1853, 1856, 1857, 1860, 1861, 1864, 1865, 1868, 1869, 1872, 1873, 1876, 1877, 1880, 1881, 1884, 1885, 1888, 1889, 1892, 1893, 1896, 1897, 1900, 1901, 1904, 1905, 1908, 1909, 1912, 1913, 1916, 1917, 1920 or 1921, preferably any one of SEQ ID Nos: 36, 37, 56, 57, 60, 61, 144, 145, 160, 161, 252, 253, 264, 265, 284, 285, 288, 289, 392, 393, 400, 401, 428, 429, 472, 473, 480, 481, 496, 497, 504, 505, 524, 525, 568, 569, 576, 577, 588, 589, 608, 609, 620, 621, 628, 629, 656, 657, 668, 669, 680, 681, 696, 697, 700, 701, 724, 725, 732, 733, 744, 745, 780, 781, 804, 805, 824, 825, 832, 833, 844, 845, 848, 849, 860, 861, 864, 865, 868, 869, 872, 873, 876, 877, 880, 881, 888, 889, 908, 909, 916, 917, 948, 949, 956, 957, 972, 973, 980, 981, 1008, 1009, 1020, 1021, 1024, 1025, 1028, 1029, 1036, 1037, 1040, 1041, 1044, 1045, 1060, 1061, 1084, 1085, 1088, 1089, 1104, 1105, 1120, 1121, 1128, 1129, 1144, 1145, 1148, 1149, 1152, 1153, 1156, 1157, 1160, 1161, 1184, 1185, 1188, 1189, 1192, 1193, 1212, 1213, 1216, 1217, 1256, 1257, 1272, 1273, 1276, 1277, 1280, 1281, 1284, 1285, 1296, 1297, 1300, 1301, 1304, 1305, 1312, 1313, 1332, 1333, 1336, 1337, 1348, 1349, 1356, 1357, 1360, 1361, 1364, 1365, 1368, 1369, 1604, 1605, 1616, 1617, 1620, 1621, 1628, 1629, 1632 or 1633. In a double-stranded oligonucleotide of the invention: (a) the nucleobase sequence of the antisense strand may consist of between 10 to 25, 10 to 30, 12 to 25, 13 to 25, 14 to 25, 15 to 25, 16 to 25, 17 to 25, 18 to 25, 19 to 25, 20 to 25, 21 to 25, 22 to 25, 23 to 25, 19 to 24, 20 to 24, 21 to 24, 22 to 24, 19 to 23, 20 to 23, 21 to 23, 19 to 22, 20 to 22 or 19 to 21 linked nucleosides, preferably of between 19 to 23 linked nucleosides; and / or (b) the nucleobase sequence of the sense strand may consist of between 10 to 25, 10 to 30, 12 to 25, 13 to 25, 14 to 25, 15 to 25, 16 to 25, 17 to 25, 18 to 25, 19 to 25, 20 to 25, 21 to 25, 22 to 25, 23 to 25, 19 to 24, 20 to 24, 21 to 24, 22 to 24, 19 to 23, 20 to 23, 21 to 23, 19 to 22, 20 to 22 or 19 to 21 linked nucleosides, preferably of between 19 to 23 linked nucleosides. The nucleobase sequence of the antisense strand may consist of between 19 to 23 linked nucleosides and the nucleobase sequence of the sense strand may consist of between 19 to 23 linked nucleosides. Preferably the nucleobase sequence of the antisense strand may consist of between 19 to 23 linked nucleosides and the nucleobase sequence of the sense strand may consist of between 19 to 21 linked nucleosides. In a double-stranded oligonucleotide of the invention the 3’ end of the antisense strand may overhang the sense strand by between about 0 to about 6 nucleosides, preferably by about 2 nucleosides. In a double-stranded oligonucleotide of the invention the antisense strand and / or the sense strand, preferably both the antisense strand and the sense strand, may comprise at least one modification optionally selected from a modified sugar moiety and / or a modified internucleoside linkage. The antisense strand and / or the sense, preferably both the antisense strand and the sense strand, may comprise at least one modified sugar moiety. Said modified sugar moiety may comprise a non-bicyclic sugar moiety. The non-bicyclic modified sugar moiety may be a 2’-OMe modified sugar moiety and / or a 2’-fluoro modified sugar moiety. In a double-stranded oligonucleotide of the invention, the antisense strand and / or the sense strand, preferably both the antisense strand and the sense strand, may comprise at least one modified internucleoside linkage. Said at least one modified internucleoside linkage may be a phosphorothioate internucleoside linkage. The antisense strand and / or the sense strand, preferably both the antisense strand and the sense strand, may comprises at least one phosphodiester internucleoside linkage. Each internucleoside linkage of the antisense strand and / or the sense strand, preferably both the antisense strand and the sense strand, may be independently selected from a phosphodiester or a phosphorothioate internucleoside linkage. In a double-stranded oligonucleotide of the invention: (a) at least 1, at least 2, at least 3, at least 4, at least 5 or more of the internucleoside linkages of the antisense strand may be phosphorothioate internucleoside linkages, preferably wherein 4 of the internucleoside linkages of the antisense are phosphorothioate internucleoside linkages; and / or (b) at least 1, at least 2, at least 3, at least 4, at least 5 or more of the internucleoside linkages of the sense strand may be phosphorothioate internucleoside linkages, preferably wherein 4 of the internucleoside linkages of the sense strand are phosphorothioate internucleoside linkages; wherein preferably 4 of the internucleoside linkages of the sense strand and 4 of the internucleoside linkages of the antisense strand are phosphorothioate internucleoside linkages. The antisense strand may comprise at least two consecutive modified internucleoside linkages at the 5’ end; and / or the antisense strand may comprise at least two consecutive modified internucleoside linkages at the 3’ end. The sense strand may comprise at least two consecutive modified internucleoside linkages at the 5’ end; and / or the sense strand may comprise at least two consecutive modified internucleoside linkages at the 3’ end. In a double-stranded oligonucleotide of the invention, the antisense strand may comprise: (a) 5’[mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN ][fRN][mRN]3’; (b) 5’[mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][mRN][mRN][fRN][mRN][fRN][mR N][fRN][mRN][fRN][mRN][fRN][mRN]3’; (c) 5’[mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][mRN][mRN][fRN][mRN][fRN][mR N][fRN][mRN][fRN][mRN][mRN][mRN]3’; (d) 5’[mRN][fRN][mRN][mRN][mRN][fRN][mRN][fRN][fRN][mRN][mRN][mRN][mRN][fRN][mRN][fRN][m RN][mRN][mRN][mRN][mRN][mRN][mRN]3’; (e) 5’[mRN][fRN][mRN][mRN][mRN][fRN][mRN][mRN][mRN][mRN][mRN][mRN][mRN][fRN][mRN][fRN][ mRN][mRN][mRN][mRN][mRN][mRN][mRN]3’; or (f) 5’[mRN][fRN][mRN][mRN][mRN][modN][modN][modN][fRN][mRN][mRN][mRN][mRN][fRN][mRN][fRN ][mRN][mRN][mRN][mRN][mRN][mRN][mRN]3’; wherein [mRN] stands for a 2’-O-methyl modified nucleotide, [fRN] stands for a 2’-fluoro modified nucleotide and [modN] stands for a modified nucleotide; wherein each [modN] may be independently selected from any xeno nucleic acid (XNA) a 2’-O-methyl modified nucleotide or a 2’-fluoro modified nucleotide; and wherein preferably the [modR] at position 7 is modified, more preferably wherein the [modR] at position 7 is an XNA. The two 5’ most internucleoside linkages of the antisense strand may be phosphorothioate internucleoside linkages and the two 3’ most internucleoside linkages of the antisense strand may be phosphorothioate internucleoside linkages. In a double-stranded oligonucleotide of the invention, the sense strand may comprise: (a) 5’[mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN ][fRN][mRN]3’; (b) 5’[fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][fRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][ mRN][fRN][mRN][fRN]3’; (c) 5’[mRN][mRN][mRN][mRN][mRN][mRN][fRN][fRN][fRN][mRN][mRN][mRN][mRN][mRN][mRN][mRN] [mRN][mRN][mRN]3’; or (d) 5’[mRN][mRN][mRN][mRN][mRN][mRN][fRN][mRN][fRN][fRN][fRN][mRN][mRN][mRN][mRN][mRN][ mRN][mRN][mRN][mRN][mRN]3’; wherein [mRN] stands for a 2’-O-methyl modified nucleotide and [fRN] stands for a 2’-fluoro modified nucleotide. The two 5’ most internucleoside linkages of the sense strand may be phosphorothioate internucleoside linkages and the two 3’ most internucleoside linkages of the sense strand may be phosphorothioate internucleoside linkages. In a double-stranded oligonucleotide of the invention the antisense strand may comprise 5’[mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN ][fRN][mRN]3’; and the sense strand may comprise 5’[mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN ][fRN][mRN]3’; wherein [mRN] stands for a 2’-O-methyl modified nucleotide and [fRN] stands for a 2’-fluoro modified nucleotide. The two 5’ most internucleoside linkages of both the antisense strand and the sense strand may be phosphorothioate internucleoside linkages and the two 3’ most internucleoside linkages of both the antisense strand and the sense strand may be phosphorothioate internucleoside linkages. In a double-stranded oligonucleotide of the invention the antisense strand may comprise 5’[mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][mRN][mRN][fRN][mRN][fRN][mR N][fRN][mRN][fRN][mRN][fRN][mRN]3’; and the sense strand may comprise 5’[fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][fRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][ mRN][fRN][mRN][fRN]3’; wherein [mRN] stands for a 2’-O-methyl modified nucleotide and [fRN] stands for a 2’-fluoro modified nucleotide. The two 5’ most internucleoside linkages of both the antisense strand and the sense strand may be phosphorothioate internucleoside linkages and the two 3’ most internucleoside linkages of both the antisense strand and the sense strand may be phosphorothioate internucleoside linkages. In a double-stranded oligonucleotide of the invention the antisense strand may comprise 5’mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN] [fRN][mRN]3’; and the sense strand may comprise 5’[mRN][mRN][mRN][mRN][mRN][mRN][fRN][fRN][fRN][mRN][mRN][mRN][mRN][mRN][mRN][mRN] [mRN][mRN][mRN]3’; wherein [mRN] stands for a 2’-O-methyl modified nucleotide and [fRN] stands for a 2’- fluoro modified nucleotide. The two 5’ most internucleoside linkages of both the antisense strand and the sense strand may be phosphorothioate internucleoside linkages and the two 3’ most internucleoside linkages of both the antisense strand and the sense strand may be phosphorothioate internucleoside linkages. In a double-stranded oligonucleotide of the invention the antisense strand may comprise 5’[mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][mRN][mRN][fRN][mRN][fRN][mR N][fRN][mRN][fRN][mRN][mRN][mRN]3’; and the sense strand may comprise 5’[mRN][mRN][mRN][mRN][mRN][mRN][fRN][mRN][fRN][fRN][fRN][mRN][mRN][mRN][mRN][mRN][ mRN][mRN][mRN][mRN][mRN]3’; wherein [mRN] stands for a 2’-O-methyl modified nucleotide and [fRN] stands for a 2’-fluoro modified nucleotide. The two 5’ most internucleoside linkages of both the antisense strand and the sense strand may be phosphorothioate internucleoside linkages and the two 3’ most internucleoside linkages of both the antisense strand and the sense strand may be phosphorothioate internucleoside linkages. In a double-stranded oligonucleotide of the invention the antisense strand may comprise 5’[mRN][fRN][mRN][mRN][mRN][fRN][mRN][fRN][fRN][mRN][mRN][mRN][mRN][fRN][mRN][fRN][m RN][mRN][mRN][mRN][mRN][mRN][mRN]3’; and the sense strand may comprise 5’[mRN][mRN][mRN][mRN][mRN][mRN][fRN][mRN][fRN][fRN][fRN][mRN][mRN][mRN][mRN][mRN][ mRN][mRN][mRN][mRN][mRN]3’; wherein [mRN] stands for a 2’-O-methyl modified nucleotide and [fRN] stands for a 2’-fluoro modified nucleotide. The two 5’ most internucleoside linkages of both the antisense strand and the sense strand may be phosphorothioate internucleoside linkages and the two 3’ most internucleoside linkages of both the antisense strand and the sense strand may be phosphorothioate internucleoside linkages. In a double-stranded oligonucleotide of the invention the antisense strand may comprise 5’[mRN][fRN][mRN][mRN][mRN][fRN][mRN][mRN][mRN][mRN][mRN][mRN][mRN][fRN][mRN][fRN][ mRN][mRN][mRN][mRN][mRN][mRN][mRN]3’; and the sense strand may comprise 5’[mRN][mRN][mRN][mRN][mRN][mRN][fRN][mRN][fRN][fRN][fRN][mRN][mRN][mRN][mRN][mRN][ mRN][mRN][mRN][mRN][mRN]3’; wherein [mRN] stands for a 2’-O-methyl modified nucleotide and [fRN] stands for a 2’-fluoro modified nucleotide. The two 5’ most internucleoside linkages of both the antisense strand and the sense strand may be phosphorothioate internucleoside linkages and the two 3’ most internucleoside linkages of both the antisense strand and the sense strand may be phosphorothioate internucleoside linkages. In a double-stranded oligonucleotide of the invention the antisense strand may comprise a 5’ 5- vinylphosphonate (5VP) modification. In a double-stranded oligonucleotide of the invention the antisense strand and / or the sense strand may comprise at least one modified nucleobase, optionally selected from 5-methylcytosine or methyl-uracil. The invention also provides a polynucleotide conjugate comprising a double-stranded oligonucleotide of the invention and a conjugate group. The conjugate group may comprise a conjugate linker and a conjugate moiety. The conjugate linker may consist of a single bond. The conjugate linker may be cleavable. The conjugate linker may comprise 1-3 linker- nucleosides. The conjugate linker may be a phosphate. The conjugate group may be attached to the modified oligonucleotide at the 5’-end of the modified oligonucleotide. The conjugate group may be attached to the modified oligonucleotide at the 3’-end of the modified oligonucleotide. The conjugate group may comprise N- acetyl galactosamine (GalNAc). The GalNAc may be present at the 5’ and / or the 3’ of (i) the antisense strand and / or (ii) the sense strand. Preferably the GalNAc is present at the 5’ and / or 3’ end of the sense strand, more preferably at the 3’ end of the sense strand. The conjugate group may have the following structure: . The conjugate group may comprise a cell-targeting moiety. The polynucleotide conjugate may comprise a terminal group. The terminal group may be an abasic sugar moiety. The invention also provides a chirally enriched population of double-stranded oligonucleotide or polynucleotide conjugate of the invention, wherein the population is enriched for double-stranded oligonucleotides comprising at least one particular phosphorothioate internucleoside linkage having a particular stereochemical configuration, or polynucleotide conjugates comprising said double-stranded oligonucleotides. The chirally enriched population may be enriched for double-stranded oligonucleotides comprising at least one particular phosphorothioate internucleoside linkage having the (Sp) or (Rp) configuration, or polynucleotide conjugates comprising said double-stranded oligonucleotides. The chirally enriched population may be enriched for double-stranded oligonucleotides having a particular, independently selected stereochemical configuration at each phosphorothioate internucleoside linkage, or polynucleotide conjugates comprising said double-stranded oligonucleotides. The chirally enriched population may be enriched for double-stranded oligonucleotides having the (Rp) configuration at one particular phosphorothioate internucleoside linkage and the (Sp) configuration at each of the remaining phosphorothioate internucleoside linkages, or polynucleotide conjugates comprising said double-stranded oligonucleotides. The chirally enriched population may be enriched for double-stranded oligonucleotides having at least 2 or at least 3 contiguous phosphorothioate internucleoside linkages in the Sp, Sp, and Rp configurations, in the 5’ to 3’ direction, or polynucleotide conjugates comprising said double-stranded oligonucleotides. In a population of double-stranded oligonucleotides comprising double-stranded or polynucleotide conjugates of the invention, all of the phosphorothioate internucleoside linkages of the double-stranded oligonucleotides may be stereorandom. The invention further provides a pharmaceutical composition comprising a double-stranded oligonucleotide, polynucleotide conjugate, or population of the invention, and a pharmaceutically acceptable diluent or carrier. The pharmaceutically acceptable diluent may be water or phosphate-buffered saline. The pharmaceutical composition may consist essentially of a double-stranded oligonucleotide, polynucleotide conjugate, or population of the invention, and water or phosphate-buffered saline. The invention also provides a method comprising administering to a subject a double-stranded oligonucleotide, a polynucleotide conjugate, a population, or a pharmaceutical composition of the invention. The invention further provides a method of treating a disease associated with PSD3 comprising administering to a subject having a disease associated with PSD3 a therapeutically effective amount of a double- stranded oligonucleotide, a polynucleotide conjugate, a population, or a pharmaceutical composition of the invention; thereby treating the disease associated with PSD3. The disease associated with PSD3 may be liver disease, fatty liver disease (FLD), nonalcoholic fatty liver disease (NAFLD), hepatic steatosis, non-alcoholic steatohepatitis (NASH), liver cirrhosis, hepatocellular carcinoma, alcoholic liver disease, alcoholic steatohepatitis (ASH), HCV hepatitis, chronic hepatitis, hereditary hemochromatosis, or primary sclerosing cholangitis. Administering a double-stranded oligonucleotide, a polynucleotide conjugate, a population, or a pharmaceutical composition of the invention may reduce liver damage, steatosis, liver fibrosis, liver inflammation, liver scarring or cirrhosis, liver failure, liver enlargement, elevated transaminases, or hepatic fat accumulation in the subject. The invention also provides a method of reducing expression of PSD3 in a cell comprising contacting the cell with a double-stranded oligonucleotide, a polynucleotide conjugate, a population, or a pharmaceutical composition of the invention. The cell may be a liver cell. The invention further provides the use of a double-stranded oligonucleotide, a polynucleotide conjugate, a population, or a pharmaceutical composition of the invention for treating a disease associated with PSD3. The invention also provides the use of a double-stranded oligonucleotide, a polynucleotide, a population, or a pharmaceutical composition of the invention in the manufacture of a medicament for treating a disease associated with PSD3. The disease associated with PSD3 may be liver disease, fatty liver disease (FLD), nonalcoholic fatty liver disease (NAFLD), hepatic steatosis, non-alcoholic steatohepatitis (NASH), liver cirrhosis, hepatocellular carcinoma, alcoholic liver disease, alcoholic steatohepatitis (ASH), HCV hepatitis, chronic hepatitis, hereditary hemochromatosis, or primary sclerosing cholangitis. The invention further provides a double-stranded oligonucleotide, a polynucleotide conjugate, a population, or a pharmaceutical composition of the invention for use in a method of treating a disease associated with PSD3. The disease associated with PSD3 may be liver disease, fatty liver disease (FLD), nonalcoholic fatty liver disease (NAFLD), hepatic steatosis, non-alcoholic steatohepatitis (NASH), liver cirrhosis, hepatocellular carcinoma, alcoholic liver disease, alcoholic steatohepatitis (ASH), HCV hepatitis, chronic hepatitis, hereditary hemochromatosis, or primary sclerosing cholangitis. BRIEF DESCRIPTION OF THE DRAWINGS Various aspects of the disclosure are set forth with particularity in the appended claims. A better understanding of the features and advantages of the present disclosure will be obtained by reference to the following detailed description that sets forth illustrative aspects, in which the principles of the disclosure are utilized, and the accompanying drawings below. Figure 1: Schematic of preferred modification patterns for antisense strands of the invention. Black circles = 2’OMe; Hashed circles = 2’F; dotted circles = modified nucleosides; black arches = optional phosphorothioate linkers Figure 2: Schematic of preferred modification patterns for sense strands of the invention. Black circles = 2’OMe; Hashed circles = 2’F; black arches = optional phosphorothioate linkers DETAILED DESCRIPTION Definitions It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive. Herein, the use of the singular includes the plural unless specifically stated otherwise. As used herein, the use of “or” means “and / or” unless stated otherwise. Furthermore, the use of the term “including” as well as other forms, such as “includes” and “included”, is not limiting. Also, terms such as “element” or “component” encompass both elements and components comprising one unit and elements and components that comprise more than one subunit, unless specifically stated otherwise. The section headings used herein are for organizational purposes only and are not to be construed as limiting the subject matter described. All documents, or portions of documents, cited in this application, including, but not limited to, patents, patent applications, articles, books, and treatises, are hereby expressly incorporated- by-reference for the portions of the document discussed herein, as well as in their entirety. Unless specific definitions are provided, the nomenclature used in connection with, and the procedures and techniques of, analytical chemistry, synthetic organic chemistry, and medicinal and pharmaceutical chemistry described herein are those well-known and commonly used in the art. The description of embodiments of the disclosure is not intended to be exhaustive or to limit the disclosure to the precise form disclosed. While specific embodiments of, and examples for, the disclosure are described herein for illustrative purposes, various equivalent modifications are possible within the scope of the disclosure, as those skilled in the relevant art will recognize. For example, while method steps or functions are presented in a given order, alternative embodiments may perform functions in a different order, or functions may be performed substantially concurrently. The teachings of the disclosure provided herein can be applied to other procedures or methods as appropriate. The various embodiments described herein can be combined to provide further embodiments. Aspects of the disclosure can be modified, if necessary, to employ the compositions, functions and concepts described herein to provide yet further embodiments of the disclosure. Moreover, due to biological functional equivalency considerations, some changes can be made in protein structure without affecting the biological or chemical action in kind or amount. These and other changes can be made to the disclosure in light of the detailed description. All such modifications are intended to be included within the scope of the appended claims. As used herein, the term "capable of" when used with a verb, encompasses or means the action of the corresponding verb. For example, "capable of interacting" also means interacting, "capable of cleaving" also means cleaves, "capable of binding" also means binds and "capable of specifically targeting…" also means specifically targets. Numeric ranges are inclusive of the numbers defining the range. Where a range of values is provided, it is understood that each intervening value, to the tenth of the unit of the lower limit unless the context clearly dictates otherwise, between the upper and lower limits of that range is also specifically disclosed. Each smaller range between any stated value or intervening value in a stated range and any other stated or intervening value in that stated range is encompassed within this disclosure. The upper and lower limits of these smaller ranges may independently be included or excluded in the range, and each range where either, neither or both limits are included in the smaller ranges is also encompassed within this disclosure, subject to any specifically excluded limit in the stated range. Where the stated range includes one or both of the limits, ranges excluding either or both of those included limits are also included in this disclosure. “About” may generally mean an acceptable degree of error for the quantity measured given the nature or precision of the measurements. Exemplary degrees of error are within 20 percent (%), typically, within 10%, and more typically, within 5% of a given value or range of values. Preferably, the term “about” shall be understood herein as plus or minus (±) 5%, preferably ± 4%, ± 3%, ± 2%, ± 1%, ± 0.5%, ± 0.1%, of the numerical value of the number with which it is being used. The term "consisting of'' refers to compositions, methods, and respective components thereof as described herein, which are exclusive of any element not recited in that description of the invention. As used herein the term "consisting essentially of'' refers to those elements required for a given invention. The term permits the presence of elements that do not materially affect the basic and novel or functional characteristic(s) of that invention (i.e., inactive or non-immunogenic ingredients). Embodiments described herein as “comprising” one or more features may also be considered as disclosure of the corresponding embodiments “consisting of” and / or “consisting essentially of” such features. Concentrations, amounts, volumes, percentages and other numerical values may be presented herein in a range format. It is also to be understood that such range format is used merely for convenience and brevity and should be interpreted flexibly to include not only the numerical values explicitly recited as the limits of the range but also to include all the individual numerical values or sub-ranges encompassed within that range as if each numerical value and sub-range is explicitly recited. The polynucleotides of the present invention may be prepared by any means known in the art. For example, large amounts of the polynucleotides may be produced by replication in a suitable host cell. The polynucleotides of the present invention may preferably be produced by chemical synthesis, e.g., by the phosphoramidite method or the tri-ester method and may be performed on commercial automated oligonucleotide synthesizers. A double-stranded oligonucleotide may be obtained from the single stranded product of chemical synthesis either by synthesizing the complementary strand and annealing the strand together under appropriate conditions or by adding the complementary strand using DNA polymerase with an appropriate primer sequence. A “variant” nucleic acid sequence has substantial homology or substantial similarity to a reference nucleic acid sequence (or a fragment thereof). A nucleic acid sequence or fragment thereof is “substantially homologous” (or “substantially identical”) to a reference sequence if, when optimally aligned (with appropriate nucleotide insertions or deletions) with the other nucleic acid (or its complementary strand), there is nucleotide sequence identity in at least about 70%, 75%, 80%, 85, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 99 / 5, 99.9 or more% of the nucleotide bases. Methods for homology determination of nucleic acid sequences are known in the art. Alternatively, a “variant” nucleic acid sequence is substantially homologous with (or substantially identical to) a reference sequence (or a fragment thereof) if the “variant” and the reference sequence they are capable of hybridizing under stringent (e.g., highly stringent) hybridization conditions. Nucleic acid sequence hybridization will be affected by such conditions as salt concentration (e.g. NaCl), temperature, or organic solvents, in addition to the base composition, length of the complementary strands, and the number of nucleotide base mismatches between the hybridizing nucleic acids, as will be readily appreciated by those skilled in the art. Stringent temperature conditions are preferably employed, and generally include temperatures in excess of 30°C, typically in excess of 37°C and preferably in excess of 45°C. Stringent salt conditions will ordinarily be less than 1000 mM, typically less than 500 mM, and preferably less than 200 mM. The pH is typically between 7.0 and 8.3. The combination of parameters is much more important than any single parameter. Methods of determining nucleic acid percentage sequence identity are known in the art. By way of example, when assessing nucleic acid sequence identity, a sequence having a defined number of contiguous nucleotides may be aligned with a nucleic acid sequence (having the same number of contiguous nucleotides) from the corresponding portion of a nucleic acid sequence of the present invention. Tools known in the art for determining nucleic acid percentage sequence identity include Nucleotide BLAST (as described below). The terms “decrease” "reduced", "reduction", or "inhibit" are all used herein to mean a decrease by a statistically significant amount. The terms "reduce," "reduction" or "decrease" or "inhibit" typically means a decrease by at least 10% as compared to a reference level (e.g. the absence of a given treatment) and can include, for example, a decrease by at least about 10%, at least about 20%, at least about 25%, at least about 30%, at least about 35%, at least about 40%, at least about 45%, at least about 50%, at least about 55%, at least about 60%, at least about 65%, at least about 70%, at least about 75%, at least about 80%, at least about 85%, at least about 90%, at least about 95%, at least about 98%, at least about 99% , or more. As used herein, "reduction" or "inhibition" encompasses a complete inhibition or reduction as compared to a reference level. "Complete inhibition" is a 100% inhibition (i.e., abrogation) as compared to a reference level. The terms "increased", "increase", "enhance", or "activate" are all used herein to mean an increase by a statically significant amount. The terms "increased", "increase", "enhance", or "activate" can mean an increase of at least 25%, at least 50% as compared to a reference level, for example an increase of at least about 50%, or at least about 75%, or at least about 80%, or at least about 90%, at least about 95%, or at least about 98%, or at least about 99%, or at least about 100%, or at least about 250% or more compared with a reference level, or at least about a 1.5-fold, or at least about a 2-fold, or at least about a 2.5-fold, or at least about a 3-fold, or at least about a 4-fold, or at least about a 5-fold or at least about a 10-fold increase, or any increase between 1.5-fold and 10- fold or greater as compared to a reference level. Unless otherwise indicated, the following terms have the following meanings: As used herein, “2’-deoxynucleoside” means a nucleoside comprising a 2’-H(H) deoxyfuranosyl sugar moiety. In certain embodiments, a 2’-deoxynucleoside is a 2’-β-D-deoxynucleoside and comprises a 2’-β-D- deoxyribosyl sugar moiety, which has the β-D ribosyl configuration as found in naturally occurring deoxyribonucleic acids (DNA). In certain embodiments, a 2’-deoxynucleoside may comprise a modified nucleobase or may comprise an RNA nucleobase (uracil). As used herein, “xeno nucleic acid” and “XNA” means a nucleic acid with a backbone constructed from sugars that are distinct from the natural ribose sugars found in RNA. The term XNA includes, but is not limited to unlocked nucleic acids (UNA), glycol nucleic acids (GNA), DNA, 2'-deoxy-2'-fluoro-arabinonucleic acids (2’F-ANA), threose nucleic acids (TNA), serinol nucleic acids (SNA), flexible nucleic acids (FNA), 2’NH2-RNA, 1’,2’-seco-DNA, 3(S),5-dihydroxypentyl nucleic acids, and nucleoside analogues comprising a six-membered tetrahydropyran (THP, e.g. a hexitol nucleic acid (HNA), arabinonucleic acid (ANA), or mannitol nucleic acid (MNA). Preferred XNAs include GNA, UNA and DNA. As used herein, “unlocked nucleic acid” and “UNA” mean an acyclic derivative of RNA lacking the C2'- C3'-bond of the ribose ring of RNA. As used herein, “glycol nucleic acid” and “GNA” mean a nucleic acid in which a propylene glycol group is in place of the ribose or deoxyribose sugar moiety. As used herein, “2'-deoxy-2'-fluoro-arabinonucleic acid” and “2’F-ANA” refers to a nucleic acid in which the 2’-OH has been inverted and fluorinated. As used herein, “threose nucleic acid” and “TNA” mean (3’→2’)-α-L-threose nucleic acid, in which the backbone repeat unit is one atom shorter than in RNA or DNA. As used herein “serinol nucleic acid” and “SNA” mean a nucleic acid in which a serinol (2-amino-1,3- propanediol) group is in place of the ribose or deoxyribose sugar moiety. As used herein “flexible nucleic acid” and “FNA” mean a nucleic acid in which a glycerol group is in place of the ribose or deoxyribose sugar moiety. As used herein “2’NH2-RNA” means a nucleic acid in which the 2'-OH group of the ribose moiety is replaced by a 2'-amino (2'-NH2) group. As used herein, “2’-MOE” means a 2’-OCH2CH2OCH3 group in place of the 2’-OH group of a furanosyl sugar moiety. A “2’-MOE sugar moiety” means a sugar moiety with a 2’-OCH2CH2OCH3group in place of the 2’-OH group of a furanosyl sugar moiety. Unless otherwise indicated, a 2’-MOE sugar moiety is in the β-D- ribosyl configuration. “MOE” means O-methoxyethyl. As used herein, “2’-MOE nucleoside” means a nucleoside comprising a 2’-MOE sugar moiety. As used herein, “2’-OMe” means a 2’-OCH3 group in place of the 2’-OH group of a furanosyl sugar moiety. A “2’-O-methyl sugar moiety” or “2’-OMe sugar moiety” means a sugar moiety with a 2’-OCH3group in place of the 2’-OH group of a furanosyl sugar moiety. Unless otherwise indicated, a 2’-MOE sugar moiety is in the β-D-ribosyl configuration. As used herein, “2’-OMe nucleoside” means a nucleoside comprising a 2’-OMe sugar moiety. As used herein, “2’-substituted nucleoside” means a nucleoside comprising a 2’-substituted sugar moiety. As used herein, “2’-substituted” in reference to a sugar moiety means a sugar moiety comprising at least one 2'- substituent group other than H or OH. As used herein, “3’ target site” refers to the 3’-most nucleotide of a target nucleic acid which is complementary to an antisense oligonucleotide, when the antisense oligonucleotide is hybridized to the target nucleic acid. As used herein, “5’ target site” refers to the 5’-most nucleotide of a target nucleic acid which is complementary to an antisense oligonucleotide, when the antisense oligonucleotide is hybridized to the target nucleic acid. As used herein, “5-methylcytosine” means a cytosine modified with a methyl group attached to the 5 position. A 5-methyl cytosine is a modified nucleobase. As used herein, “abasic sugar moiety” means a sugar moiety of a nucleoside that is not attached to a nucleobase. Such abasic sugar moieties are sometimes referred to in the art as “abasic nucleosides.” As used herein, “bicyclic sugar” or “bicyclic sugar moiety” means a modified sugar moiety comprising two rings, wherein the second ring is formed via a bridge connecting two of the atoms in the first ring thereby forming a bicyclic structure. In certain embodiments, the first ring of the bicyclic sugar moiety is a furanosyl moiety. In certain embodiments, the bicyclic sugar moiety does not comprise a furanosyl moiety. As used herein, “non-bicyclic modified sugar moiety” means a modified sugar moiety that comprises a modification, such as a substituent, that does not form a bridge between two atoms of the sugar to form a second ring. As used herein, “chirally enriched population” means a plurality of molecules of identical molecular formula, wherein the number or percentage of molecules within the population that contain a particular stereochemical configuration at a particular chiral center is greater than the number or percentage of molecules expected to contain the same particular stereochemical configuration at the same particular chiral center within the population if the particular chiral center were stereorandom. Chirally enriched populations of molecules having multiple chiral centers within each molecule may contain one or more stereorandom chiral centers. In certain embodiments, the molecules are modified oligonucleotides. In certain embodiments, the molecules are oligomeric compounds comprising modified oligonucleotides. As used herein, “cleavable moiety” means a bond or group of atoms that is cleaved under physiological conditions, for example, inside a cell, an animal, or a human. As used herein, “complementary” in reference to an oligonucleotide means that is at least 70% of the nucleobases of the oligonucleotide and the nucleobases of another nucleic acid or one or more regions thereof are capable of hydrogen bonding with one another when the nucleobase sequence of the oligonucleotide and the other nucleic acid are aligned in opposing directions. “Complementary region” in reference to a region of an oligonucleotide means that is at least 70% of the nucleobases of that region and the nucleobases of another nucleic acid or one or more regions thereof are capable of hydrogen bonding with one another when the nucleobase sequence of the oligonucleotide and the other nucleic acid are aligned in opposing directions, i.e. the nucleobase sequences are reverse complementary. For the avoidance of doubt, all references herein to an oligonucleotide (e.g. an antisense strand of a double-stranded oligonucleotide of the invention) as complementary to a target sequence means that the nucleobase sequence of said oligonucleotide (e.g. the antisense strand of a double-stranded oligonucleotide of the invention) is reverse complementary to said target sequence. Complementary nucleobases mean nucleobases that are capable of forming hydrogen bonds with one another. Complementary nucleobase pairs include adenine (A) and thymine (T), adenine (A) and uracil (U), cytosine (C) and guanine (G), 5-methyl cytosine (mC) and guanine (G). Certain modified nucleobases that pair with natural nucleobases or with other modified nucleobases are known in the art and are not considered complementary nucleobases as defined herein unless indicated otherwise. For example, inosine can pair, but is not considered complementary, with adenosine, cytosine, or uracil. Complementary oligonucleotides and / or nucleic acids need not have nucleobase complementarity at each nucleoside. Rather, some mismatches are tolerated. As used herein, “fully complementary” or “100% complementary” in reference to oligonucleotides means that oligonucleotides are complementary to another oligonucleotide or nucleic acid at each nucleoside of the oligonucleotide. As used herein, “conjugate group” means a group of atoms that is directly attached to an oligonucleotide. Conjugate groups include a conjugate moiety and a conjugate linker that attaches the conjugate moiety to the oligonucleotide. As used herein, “conjugate linker” means a single bond or a group of atoms comprising at least one bond that connects a conjugate moiety to an oligonucleotide. As used herein, “conjugate moiety” means a group of atoms that modifies one or more properties of a molecule compared to the identical molecule lacking the conjugate moiety, including but not limited to pharmacodynamics, pharmacokinetics, stability, binding, absorption, tissue distribution, cellular distribution, cellular uptake, charge and clearance. As used herein, “hotspot region” is a range of nucleobases on a target nucleic acid that is amenable to oligomeric agent or oligomeric compound-mediated reduction of the amount or activity of the target nucleic acid. As used herein, “internucleoside linkage” is the covalent linkage between adjacent nucleosides in an oligonucleotide. As used herein “modified internucleoside linkage” means any internucleoside linkage other than a phosphodiester internucleoside linkage. As used herein, “linked nucleosides” are nucleosides that are connected in a contiguous sequence (i.e., no additional nucleosides are presented between those that are linked). As used herein, “linker-nucleoside” means a nucleoside that links, either directly or indirectly, an oligonucleotide to a conjugate moiety. Linker-nucleosides are located within the conjugate linker of an oligomeric compound. Linker-nucleosides are not considered part of the oligonucleotide portion of an oligomeric compound even if they are contiguous with the oligonucleotide. As used herein, “mismatch” or “non-complementary” means a nucleobase of a first nucleic acid sequence that is not complementary with the corresponding nucleobase of a second nucleic acid sequence or target nucleic acid when the first and second nucleic acid sequences are aligned. As used herein, “motif” means the pattern of unmodified and / or modified sugar moieties, nucleobases, and / or internucleoside linkages, in an oligonucleotide. As used herein, “modified nucleoside” means a nucleoside comprising a modified nucleobase and / or a modified sugar moiety. As used herein, "nucleobase" means an unmodified nucleobase or a modified nucleobase. A nucleobase is a heterocyclic moiety. As used herein an “unmodified nucleobase” is adenine (A), thymine (T), cytosine (C), uracil (U), or guanine (G). As used herein, a “modified nucleobase” is a group of atoms other than unmodified A, T, C, U, or G capable of pairing with at least one other nucleobase. A “5-methyl cytosine” is a modified nucleobase. A universal base is a modified nucleobase that can pair with any one of the five unmodified nucleobases. As used herein, “nucleobase sequence” means the order of contiguous nucleobases in a nucleic acid or oligonucleotide independent of any sugar or internucleoside linkage modification. By way of example and without limitation, an oligomeric compound having the nucleobase sequence “ATCGATCG” encompasses any compounds having such nucleobase sequence, whether modified or unmodified, including, but not limited to, such compounds comprising RNA bases, such as those having sequence “AUCGAUCG” and those having some DNA bases and some RNA bases such as “AUCGATCG” and compounds having other modified nucleobases, such as “ATmCGAUCG,” whereinmC indicates a cytosine base comprising a methyl group at the 5-position. Finally, for clarity, unless otherwise indicated, the phrase “nucleobase sequence of SEQ ID NO: X”, refers only to the sequence of nucleobases in that SEQ ID NO.: X, independent of any sugar or internucleoside linkage modifications also described in such SEQ ID. As used herein, “nucleoside” means a compound or fragment of a compound comprising a nucleobase and a sugar moiety. The nucleobase and sugar moiety are each, independently, unmodified or modified. As used herein, "oligomeric agent" means a double-stranded oligonucleotide and optionally one or more additional features, such as a second oligonucleotide. As used herein, " polynucleotide conjugate" means a double-stranded oligonucleotide and optionally one or more additional features, such as a conjugate group or terminal group. A double-stranded oligonucleotide comprises a first oligonucleotide strand that is paired with a second oligonucleotide strand that is complementary to the first oligonucleotide strand. A double-stranded oligonucleotide comprises a sense oligonucleotide or strand (also known in the art as a passenger oligonucleotide or passenger strand), and an antisense oligonucleotide or strand (also known in the art as a guide oligonucleotide or guide strand). As used herein, “antisense activity” means any detectable and / or measurable change attributable to the hybridization of an antisense strand to its target nucleic acid. In certain embodiments, antisense activity is a decrease in the amount or expression of a target nucleic acid or protein encoded by such target nucleic acid compared to target nucleic acid levels or target protein levels in the absence of the antisense strand. In certain embodiments, antisense activity is the modulation of splicing of a target pre-mRNA. As used herein, “antisense agent” means an antisense strand and optionally one or more additional features, such as a sense strand. Thus, a double-stranded oligonucleotide of the invention may be described as an antisense agent. As used herein, “antisense compound” means an antisense strand and optionally one or more additional features, such as a conjugate group. An antisense agent may comprise an antisense compound and a sense strand. As used herein, “sense compound” means a sense strand and optionally one or more additional features, such as a conjugate group. As used herein, “antisense oligonucleotide” means an oligonucleotide, including the oligonucleotide portion of an antisense compound, that is capable of hybridizing to a target nucleic acid and is capable of at least one antisense activity. Antisense oligonucleotides include but are not limited to antisense RNAi oligonucleotides and antisense RNase H oligonucleotides. The double-stranded oligonucleotides of the invention are typically siRNA and so comprise an antisense RNAi oligonucleotide. As used herein, “sense oligonucleotide” or “sense strand” means an oligonucleotide, including the oligonucleotide portion of a sense compound, that is capable of hybridizing to an antisense oligonucleotide. As used herein, "oligonucleotide" means a strand of linked nucleosides connected via internucleoside linkages, wherein each nucleoside and internucleoside linkage may be modified or unmodified. Unless otherwise indicated, oligonucleotides consist of 8-50 linked nucleosides. As used herein, “modified oligonucleotide” means an oligonucleotide, wherein at least one nucleoside or internucleoside linkage is modified. As used herein, “unmodified oligonucleotide” means an oligonucleotide that does not comprise any nucleoside modifications or internucleoside modifications. As used herein, “stabilized phosphate group” means a 5’-phosphate analog that is metabolically more stable than a 5’-phosphate as naturally occurs on DNA or RNA. As used herein, “standard cell assay” means the assays described in the Examples and reasonable variations thereof. As used herein, “stereorandom chiral center” in the context of a population of molecules of identical molecular formula means a chiral center having a random stereochemical configuration. For example, in a population of molecules comprising a stereorandom chiral center, the number of molecules having the (S) configuration of the stereorandom chiral center may be but is not necessarily the same as the number of molecules having the (R) configuration of the stereorandom chiral center. The stereochemical configuration of a chiral center is considered random when it is the result of a synthetic method that is not designed to control the stereochemical configuration. In certain embodiments, a stereorandom chiral center is a stereorandom phosphorothioate internucleoside linkage. As used herein, “sugar moiety” means an unmodified sugar moiety or a modified sugar moiety. As used herein, “unmodified sugar moiety” means a 2’-OH(H) ribosyl moiety, as found in RNA (an “unmodified RNA sugar moiety”), or a 2’-H(H) deoxyribosyl sugar moiety, as found in DNA (an “unmodified DNA sugar moiety”). Unmodified sugar moieties have one hydrogen at each of the 1’, 3’, and 4’ positions, an oxygen at the 3’ position, and two hydrogens at the 5’ position. As used herein, “modified sugar moiety” or “modified sugar” means a modified furanosyl sugar moiety or a sugar surrogate. As used herein, "sugar surrogate" means a modified sugar moiety having other than a furanosyl moiety that can link a nucleobase to another group, such as an internucleoside linkage, conjugate group, or terminal group in an oligonucleotide. Modified nucleosides comprising sugar surrogates can be incorporated into one or more positions within an oligonucleotide and such oligonucleotides are capable of hybridizing to complementary oligomeric compounds or target nucleic acids. As used herein, “target nucleic acid” and “target RNA” mean a nucleic acid that an oligomeric compound is designed to affect. Target RNA means an RNA transcript and includes pre-mRNA and mRNA unless otherwise specified. As used herein, “target region” means a portion of a target nucleic acid to which an oligomeric compound is designed to hybridize. As used herein, "terminal group" means a chemical group or group of atoms that is covalently linked to a terminus of an oligonucleotide. As used herein, “cell-targeting moiety” means a conjugate group or portion of a conjugate group that is capable of binding to a particular cell type or particular cell types. As used herein, “hybridization” means the annealing of oligonucleotides and / or nucleic acids. While not limited to a particular mechanism, the most common mechanism of hybridization involves hydrogen bonding, which may be Watson-Crick, Hoogsteen or reversed Hoogsteen hydrogen bonding, between complementary nucleobases. In certain embodiments, complementary nucleic acid molecules include, but are not limited to, an antisense compound and a nucleic acid target. In certain embodiments, complementary nucleic acid molecules include, but are not limited to, an oligonucleotide and a nucleic acid target. As used herein, “RNAi agent” means an antisense agent that acts, at least in part, through RISC or Ago2 to modulate a target nucleic acid and / or protein encoded by a target nucleic acid. RNAi agents include, but are not limited to double-stranded siRNA, single-stranded RNAi (ssRNAi), and microRNA, including microRNA mimics. RNAi agents may comprise conjugate groups and / or terminal groups. In certain embodiments, an RNAi agent modulates the amount and / or activity, of a target nucleic acid. The term RNAi agent excludes antisense agents that act through RNase H. As used herein, “RNase H agent” means an antisense agent that acts through RNase H to modulate a target nucleic acid and / or protein encoded by a target nucleic acid. In certain embodiments, RNase H agents are single-stranded. In certain embodiments, RNase H agents are double-stranded. RNase H compounds may comprise conjugate groups and / or terminal groups. In certain embodiments, an RNase H agent modulates the amount and / or activity of a target nucleic acid. The term RNase H agent excludes antisense agents that act principally through RISC / Ago2. As used herein, “reducing” or “inhibiting” PSD3 means reducing expression of PSD3 RNA and / or protein levels in the presence of an oligomeric compound or oligomeric agent described herein compared to expression of PSD3 RNA and / or protein levels in the absence of an oligomeric compound or oligomeric agent described herein. As used herein, “pharmaceutically acceptable carrier or diluent” means any substance suitable for use in administering to an animal. Certain such carriers enable pharmaceutical compositions to be formulated as, for example, tablets, pills, dragees, capsules, liquids, gels, syrups, slurries, suspension and lozenges for the oral ingestion by a subject. In certain embodiments, a pharmaceutically acceptable carrier or diluent is sterile water, sterile saline, sterile buffer solution or sterile artificial cerebrospinal fluid. As used herein “pharmaceutically acceptable salts” means physiologically and pharmaceutically acceptable salts of compounds. Pharmaceutically acceptable salts retain the desired biological activity of the parent compound and do not impart undesired toxicological effects thereto. For example, the term “pharmaceutically acceptable” may refer to salts, excipients, carriers, diluents, etc. approved by a regulatory agency of the Federal or a state government, or listed in the U.S. Pharmacopeia, European Pharmacopeia, or other generally recognized pharmacopeia. As used herein “pharmaceutical composition” means a mixture of substances suitable for administering to a subject. For example, a pharmaceutical composition may comprise an oligomeric compound and a sterile aqueous solution. In certain embodiments, a pharmaceutical composition shows activity in free uptake assay in certain cell lines. As used herein “prodrug” means a therapeutic agent in a first form outside the body that is converted to a second form within an animal or cells thereof. Typically, conversion of a prodrug within the animal is facilitated by the action of an enzymes (e.g., endogenous or viral enzyme) or chemicals present in cells or tissues and / or by physiologic conditions. In certain embodiments, the first form of the prodrug is less active than the second form. As used herein, “treating” means improving a subject’s disease or condition by administering an oligomeric agent or oligomeric compound described herein. In certain embodiments, treating a subject improves a symptom relative to the same symptom in the absence of the treatment. In certain embodiments, treatment reduces in the severity or frequency of a symptom, or delays the onset of a symptom, slows the progression of a symptom, or slows the severity or frequency of a symptom. As used herein, “therapeutically effective amount” means an amount of a pharmaceutical agent or composition that has been observed to provide a therapeutic benefit to an animal. For example, a therapeutically effective amount may be observed to improve a symptom of a disease. The terms "individual”, "subject”, and "patient”, are used interchangeably herein to refer to a mammalian subject for whom diagnosis, prognosis, disease monitoring, treatment, therapy, and / or therapy optimisation is desired. The mammal can be (without limitation) a human, non-human primate, mouse, rat, dog, cat, horse, or cow. In a preferred embodiment, the individual, subject, or patient is a human. An “individual” may be an adult, juvenile or infant. An “individual” may be male or female. A "subject in need" of treatment for a particular condition can be an individual having that condition, diagnosed as having that condition, or at risk of developing that condition. A subject can be one who has been previously diagnosed with or identified as suffering from or having a condition in need of treatment or one or more complications or symptoms related to such a condition, and optionally, have already undergone treatment for a condition as defined herein or the one or more complications or symptoms related to said condition. Alternatively, a subject can also be one who has not been previously diagnosed as having a condition as defined herein or one or more or symptoms or complications related to said condition. For example, a subject can be one who exhibits one or more risk factors for a condition, or one or more or symptoms or complications related to said condition or a subject who does not exhibit risk factors. As used herein, the term “healthy individual” refers to an individual or group of individuals who are in a healthy state, e.g., individuals who have not shown any symptoms of the disease, have not been diagnosed with the disease and / or are not likely to develop the disease e.g., a thrombotic event. Preferably said healthy individual(s) is not on medication affecting haemostasis and has not been diagnosed with any other disease. The one or more healthy individuals may have a similar sex, age, and / or body mass index (BMI) as compared with the test individual. Application of standard statistical methods used in medicine permits determination of normal levels of expression in healthy individuals, and significant deviations from such normal levels. Herein the terms “control” and “reference population” are used interchangeably. PDS3 The present inventors have surprisingly demonstrated that double-stranded oligonucleotides targeting a particular transcript for Pleckstrin and Sec7 Domain Containing 3 (PSD3) are capable of significantly reducing the amount or activity of PSD3 RNA in a cell. Accordingly, the present invention relates to double-stranded oligonucleotides which target said PSD3 transcript. In other words, the target nucleic acid of the present invention is said PSD3 transcript, or a region or fragment thereof. Contacting a cell with a double-stranded oligonucleotide which targets said PSD3 transcript typically reduce the amount of PSD3 RNA. Contacting a cell with a double-stranded oligonucleotide which targets said PSD3 transcript may reduce the amount of PSD3 protein. Said double-stranded oligonucleotide may be as described herein, and may be in the form of an isolated double-stranded oligonucleotides, or a polynucleotide conjugate, composition or and population comprising such a double-stranded oligonucleotide, as described herein. The double-stranded oligonucleotides of the invention comprise an antisense strand (also known as a guide strand) which comprises a nucleobase sequence that is at least 80% complementary to an equal portion of said PSD3 transcript. The double-stranded oligonucleotides of the invention comprise a sense strand (also known as a passenger strand) which comprises a nucleobase sequence that is at least 80% identical to an equal portion of said PSD3 transcript. Said PSD3 transcript typically has the nucleic acid sequence set forth in SEQ ID NO: 1 (ENSEMBL Accession No. ENST00000327040.13, corresponding to GENBANK Accession No. NM_015310.4, both accessed 16 September 2023). An exemplary human PSD3 protein sequence is set forth in UniProt Accession No. Q9NYI0 (version 2, accessed 17 September 2023). The PSD3 transcript may have a nucleic acid sequence that is at least 80%, at least 90%, at least 95%, at least 96%, at least 97%, a least 98%, at least 99%, at least 99.5%, at least 99.9% or more identical to SEQ ID NO: 1. The PSD3 transcript may have a nucleic acid sequence that differs from SEQ ID NO: 1 by no more than 500, no more than 400, no more than 300, no more than 200, no more than 150, no more than 100, no more than 50, no more than 40, no more than 30, no more than 25, no more than 20, no more than 15, no more than 10, no more than 9, no more than 8, no more than 7, no more than 6, no more than 5, no more than 4, no more than 3, no more than 2, or no more than 1 nucleobase from SEQ ID NO: 1. The PSD3 transcript of SEQ ID NO: 1 is 11,704 bps. A double-stranded oligonucleotide of the invention may target any equal length portion of said transcript. By way of non-limiting example, a double-stranded oligonucleotide of the invention may target a region of the PSD3 transcript corresponding to nucleobases 295 to 313 or nucleobases 7655 to 7673 of SEQ ID NO: 1. The present inventors have identified hotspots within the PSD3 transcript of SEQ ID NO: 1. As exemplified herein, double-stranded oligonucleotides targeting regions comprising or consisting of these hotspots, or fragments thereof may have increased antisense activity compared with double-stranded oligonucleotides targeting other regions of said PSD3 transcript. In other words, double-stranded oligonucleotides targeting regions comprising or consisting of these hotspots, or fragments thereof may reduce the amount of PSD3 RNA and / or PSD3 protein by a greater amount than double-stranded oligonucleotides targeting regions outside these hotspots. PSD3 hotspots may comprise or consist of a nucleobase sequence within a nucleobase sequence corresponding to from about nucleobase 1 to about nucleobase 9000 of SEQ ID NO: 1, preferably from about nucleobase 1 to about nucleobase 8500 of SEQ ID NO: 1, more preferably from about nucleobase 1 to about nucleobase 8250 of SEQ ID NO: 1, even more preferably from about nucleobase 1 to about nucleobase 8100 of SEQ ID NO: 1. In some preferred embodiments, a PSD3 hotspot may comprise or consist of a nucleobase sequence within a nucleobase sequence corresponding to from about nucleobase 1 to about nucleobase 8100 of SEQ ID NO: 1. A PSD3 hotspot may preferably comprise or consist of a nucleobase sequence within a nucleobase sequence corresponding to from about nucleobase 1 to about nucleobase 700 of SEQ ID NO: 1, more preferably from about nucleobase 1 to about nucleobase 650 of SEQ ID NO: 1, even more preferably from about nucleobase 1 to about nucleobase 600 of SEQ ID NO: 1. In some preferred embodiments, a PSD3 hotspot may comprise or consist of a nucleobase sequence within a nucleobase sequence corresponding to from about nucleobase 1 to about nucleobase 600 of SEQ ID NO: 1. A PSD3 hotspot may preferably comprise or consist of a nucleobase sequence within a nucleobase sequence corresponding to from about nucleobase 1000 to about nucleobase 4000 of SEQ ID NO: 1, more preferably from about nucleobase 1200 to about nucleobase 4000 of SEQ ID NO: 1, even more preferably from about nucleobase 1200 to about nucleobase 3750 of SEQ ID NO: 1, yet more preferably from about nucleobase 1200 to about nucleobase 3500 of SEQ ID NO: 1, even yet more preferably from about nucleobase 1400 to about nucleobase 3500 of SEQ ID NO: 1. In some preferred embodiments, a PSD3 hotspot may comprise or consist of a nucleobase sequence within a nucleobase sequence corresponding to from about nucleobase 1400 to about nucleobase 3500 of SEQ ID NO: 1. A PSD3 hotspot may preferably comprise or consist of a nucleobase sequence within a nucleobase sequence corresponding to from about nucleobase 7000 to about nucleobase 9000 of SEQ ID NO: 1, more preferably from about nucleobase 7000 to about nucleobase 8500 of SEQ ID NO: 1, even more preferably from about nucleobase 7250 to about nucleobase 8500 of SEQ ID NO: 1, yet more preferably from about nucleobase 7250 to about nucleobase 8100 of SEQ ID NO: 1, even yet more preferably from about nucleobase 7500 to about nucleobase 8100 of SEQ ID NO: 1. In some preferred embodiments, a PSD3 hotspot may comprise or consist of a nucleobase sequence within a nucleobase sequence corresponding to from about nucleobase 7500 to about nucleobase 8100 of SEQ ID NO: 1. In some preferred embodiments, a PSD3 hotspot may comprise or consist of a nucleobase sequence within a nucleobase sequence corresponding to: (i) from about nucleobase 1 to about nucleobase 8100 of SEQ ID NO: 1; from about nucleobase 1 to about nucleobase 600 of SEQ ID NO: 1; from about nucleobase 1400 to about nucleobase 3500 of SEQ ID NO: 1; or from about nucleobase 7500 to about nucleobase 8100 of SEQ ID NO: 1. Double-stranded Oligonucleotides The present invention particularly relates to double-stranded oligonucleotides which target a PSD3 transcript or region thereof, particularly a PSD3 hotspot as defined herein. The double-stranded oligonucleotides of the invention may consist essentially of RNA or DNA, preferably RNA. Thus, the double-stranded oligonucleotide of the invention is an RNAi agent as defined herein, particularly an siRNA. The double-stranded oligonucleotides of the invention, and particularly the antisense and sense strands of said double-stranded oligonucleotides, comprise or consist of linked nucleosides. Oligonucleotides may be unmodified oligonucleotides (RNA or DNA) or may be modified oligonucleotides. Modified oligonucleotides comprise at least one modification relative to unmodified RNA or DNA. That is, modified oligonucleotides comprise at least one modified nucleoside (comprising a modified sugar moiety and / or a modified nucleobase) and / or at least one modified internucleoside linkage. Certain modified nucleosides and modified internucleoside linkages suitable for use in modified oligonucleotides are described below. In particular, the invention provides a double-stranded oligonucleotide comprising an antisense strand and a sense strand, wherein the antisense strand comprises a nucleobase sequence which comprises or consists of a nucleobase sequence that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% complementary to an equal length portion of a PSD3 nucleic acid having the nucleobase sequence of SEQ ID NO: 1. A double-stranded oligonucleotide of the invention may comprise an antisense strand that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% complementary to an equal length portion within a nucleobase sequence corresponding to from about nucleobase 1 to about nucleobase 9000 of SEQ ID NO: 1, preferably corresponding to from about nucleobase 1 to about nucleobase 8500 of SEQ ID NO: 1, more preferably corresponding to from about nucleobase 1 to about nucleobase 8250 of SEQ ID NO: 1, even more preferably corresponding to from about nucleobase 1 to about nucleobase 8100 of SEQ ID NO: 1. In some preferred embodiments, a double-stranded oligonucleotide of the invention may comprise an antisense strand that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% complementary to an equal length portion within a nucleobase sequence corresponding to from about nucleobase 1 to about nucleobase 8100 of SEQ ID NO: 1. A double-stranded oligonucleotide of the invention may comprise an antisense strand that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% complementary to an equal length portion within a nucleobase sequence corresponding from about nucleobase 1 to about nucleobase 700 of SEQ ID NO: 1, preferably corresponding to from about nucleobase 1 to about nucleobase 650 of SEQ ID NO: 1, more preferably corresponding to from about nucleobase 1 to about nucleobase 600 of SEQ ID NO: 1. In some preferred embodiments, a double-stranded oligonucleotide of the invention may comprise an antisense strand that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% complementary to an equal length portion within a nucleobase sequence corresponding to from about nucleobase 1 to about nucleobase 600 of SEQ ID NO: 1. A double-stranded oligonucleotide of the invention may comprise an antisense strand that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% complementary to an equal length portion within a nucleobase sequence corresponding to from about nucleobase 1000 to about nucleobase 4000 of SEQ ID NO: 1, preferably corresponding to from about nucleobase 1200 to about nucleobase 4000 of SEQ ID NO: 1, more preferably corresponding to from about nucleobase 1200 to about nucleobase 3750 of SEQ ID NO: 1, yet more preferably corresponding to from about nucleobase 1200 to about nucleobase 3500 of SEQ ID NO: 1, even yet more preferably corresponding to from about nucleobase 1400 to about nucleobase 3500 of SEQ ID NO: 1. In some preferred embodiments, a double-stranded oligonucleotide of the invention may comprise an antisense strand that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% complementary to an equal length portion within a nucleobase sequence corresponding to from about nucleobase 1400 to about nucleobase 3500 of SEQ ID NO: 1. A double-stranded oligonucleotide of the invention may comprise an antisense strand that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% complementary to an equal length portion within a nucleobase sequence corresponding to from about nucleobase 7000 to about nucleobase 9000 of SEQ ID NO: 1, preferably corresponding to from about nucleobase 7000 to about nucleobase 8500 of SEQ ID NO: 1, more preferably corresponding to from about nucleobase 7250 to about nucleobase 8500 of SEQ ID NO: 1, yet more preferably corresponding to from about nucleobase 7250 to about nucleobase 8100 of SEQ ID NO: 1, even yet more preferably corresponding to from about nucleobase 7500 to about nucleobase 8100 of SEQ ID NO: 1. In some preferred embodiments, a double-stranded oligonucleotide of the invention may comprise an antisense strand that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% complementary to an equal length portion within a nucleobase sequence corresponding to from about nucleobase 7500 to about nucleobase 8100 of SEQ ID NO: 1. In some preferred embodiments, a double-stranded oligonucleotide of the invention may comprise an antisense strand that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% complementary to an equal length portion within a nucleobase sequence corresponding to: from about nucleobase 1 to about nucleobase 8100 of SEQ ID NO: 1; from about nucleobase 1 to about nucleobase 600 of SEQ ID NO: 1; from about nucleobase 1400 to about nucleobase 3500 of SEQ ID NO: 1; or from about nucleobase 7500 to about nucleobase 8100 of SEQ ID NO: 1. In some preferred embodiments, a double-stranded oligonucleotide of the invention may comprise an antisense strand that is at least 90% complementary to an equal length portion within a nucleobase sequence corresponding to: from about nucleobase 1 to about nucleobase 8100 of SEQ ID NO: 1; from about nucleobase 1 to about nucleobase 600 of SEQ ID NO: 1; from about nucleobase 1400 to about nucleobase 3500 of SEQ ID NO: 1; or from about nucleobase 7500 to about nucleobase 8100 of SEQ ID NO: 1. In some preferred embodiments, a double-stranded oligonucleotide of the invention may comprise an antisense strand that is at least 95% complementary to an equal length portion within a nucleobase sequence corresponding to: from about nucleobase 1 to about nucleobase 8100 of SEQ ID NO: 1; from about nucleobase 1 to about nucleobase 600 of SEQ ID NO: 1; from about nucleobase 1400 to about nucleobase 3500 of SEQ ID NO: 1; or from about nucleobase 7500 to about nucleobase 8100 of SEQ ID NO: 1. In some preferred embodiments, a double-stranded oligonucleotide of the invention may comprise an antisense strand that is at least 99% complementary to an equal length portion within a nucleobase sequence corresponding to: from about nucleobase 1 to about nucleobase 8100 of SEQ ID NO: 1; from about nucleobase 1 to about nucleobase 600 of SEQ ID NO: 1; from about nucleobase 1400 to about nucleobase 3500 of SEQ ID NO: 1; or from about nucleobase 7500 to about nucleobase 8100 of SEQ ID NO: 1. In some preferred embodiments, a double-stranded oligonucleotide of the invention may comprise an antisense strand that is complementary to an equal length portion within a nucleobase sequence corresponding to: from about nucleobase 1 to about nucleobase 8100 of SEQ ID NO: 1; from about nucleobase 1 to about nucleobase 600 of SEQ ID NO: 1; from about nucleobase 1400 to about nucleobase 3500 of SEQ ID NO: 1; or from about nucleobase 7500 to about nucleobase 8100 of SEQ ID NO: 1. The sense strand of a double-stranded oligonucleotide of the invention may comprise a nucleobase sequence which comprises or consists of a nucleobase sequence that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% identical to an equal length portion of a PSD3 nucleic acid having the nucleobase sequence of SEQ ID NO: 1. A double-stranded oligonucleotide of the invention may comprise a sense strand that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% identical to an equal length portion within a nucleobase sequence corresponding to from about nucleobase 1 to about nucleobase 9000 of SEQ ID NO: 1, preferably corresponding to from about nucleobase 1 to about nucleobase 8500 of SEQ ID NO: 1, more preferably corresponding to from about nucleobase 1 to about nucleobase 8250 of SEQ ID NO: 1, even more preferably corresponding to from about nucleobase 1 to about nucleobase 8100 of SEQ ID NO: 1. In some preferred embodiments, a double-stranded oligonucleotide of the invention may comprise a sense strand that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% identical to an equal length portion within a nucleobase sequence corresponding to from about nucleobase 1 to about nucleobase 8100 of SEQ ID NO: 1. A double-stranded oligonucleotide of the invention may comprise a sense strand that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% identical to an equal length portion within a nucleobase sequence corresponding to from about nucleobase 1 to about nucleobase 700 of SEQ ID NO: 1, preferably corresponding to from about nucleobase 1 to about nucleobase 650 of SEQ ID NO: 1, more preferably corresponding to from about nucleobase 1 to about nucleobase 600 of SEQ ID NO: 1. In some preferred embodiments, a double-stranded oligonucleotide of the invention may comprise a sense strand that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% identical to an equal length portion within a nucleobase sequence corresponding to from about nucleobase 1 to about nucleobase 600 of SEQ ID NO: 1. A double-stranded oligonucleotide of the invention may comprise a sense strand that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% identical to an equal length portion within a nucleobase sequence corresponding to from about nucleobase 1000 to about nucleobase 4000 of SEQ ID NO: 1, preferably corresponding to from about nucleobase 1200 to about nucleobase 4000 of SEQ ID NO: 1, more preferably corresponding to from about nucleobase 1200 to about nucleobase 3750 of SEQ ID NO: 1, yet more preferably corresponding to from about nucleobase 1200 to about nucleobase 3500 of SEQ ID NO: 1, even yet more preferably corresponding to from about nucleobase 1400 to about nucleobase 3500 of SEQ ID NO: 1. In some preferred embodiments, a double-stranded oligonucleotide of the invention may comprise a sense strand that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% identical to an equal length portion within a nucleobase sequence corresponding to from about nucleobase 1400 to about nucleobase 3500 of SEQ ID NO: 1. A double-stranded oligonucleotide of the invention may comprise a sense strand that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% identical to an equal length portion within a nucleobase sequence corresponding to from about nucleobase 7000 to about nucleobase 9000 of SEQ ID NO: 1, preferably corresponding to from about nucleobase 7000 to about nucleobase 8500 of SEQ ID NO: 1, more preferably corresponding to from about nucleobase 7250 to about nucleobase 8500 of SEQ ID NO: 1, yet more preferably corresponding to from about nucleobase 7250 to about nucleobase 8100 of SEQ ID NO: 1, even yet more preferably corresponding to from about nucleobase 7500 to about nucleobase 8100 of SEQ ID NO: 1. In some preferred embodiments, a double-stranded oligonucleotide of the invention may comprise a sense strand that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% identical to an equal length portion within a nucleobase sequence corresponding to from about nucleobase 7500 to about nucleobase 8100 of SEQ ID NO: 1. In some preferred embodiments, a double-stranded oligonucleotide of the invention may comprise a sense strand that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% identical to an equal length portion within a nucleobase sequence corresponding to: from about nucleobase 1 to about nucleobase 8100 of SEQ ID NO: 1; from about nucleobase 1 to about nucleobase 600 of SEQ ID NO: 1; from about nucleobase 1400 to about nucleobase 3500 of SEQ ID NO: 1; or from about nucleobase 7500 to about nucleobase 8100 of SEQ ID NO: 1. In some preferred embodiments, a double-stranded oligonucleotide of the invention may a sense strand that is at least 90% identical to an equal length portion within a nucleobase sequence corresponding to: from about nucleobase 1 to about nucleobase 8100 of SEQ ID NO: 1; from about nucleobase 1 to about nucleobase 600 of SEQ ID NO: 1; from about nucleobase 1400 to about nucleobase 3500 of SEQ ID NO: 1; or from about nucleobase 7500 to about nucleobase 8100 of SEQ ID NO: 1. In some preferred embodiments, a double-stranded oligonucleotide of the invention may a sense strand that is at least 95% identical to an equal length portion within a nucleobase sequence corresponding to: from about nucleobase 1 to about nucleobase 8100 of SEQ ID NO: 1; from about nucleobase 1 to about nucleobase 600 of SEQ ID NO: 1; from about nucleobase 1400 to about nucleobase 3500 of SEQ ID NO: 1; or from about nucleobase 7500 to about nucleobase 8100 of SEQ ID NO: 1. In some preferred embodiments, a double-stranded oligonucleotide of the invention may comprise a sense strand that is at least 99% identical to an equal length portion within a nucleobase sequence corresponding to: from about nucleobase 1 to about nucleobase 8100 of SEQ ID NO: 1; from about nucleobase 1 to about nucleobase 600 of SEQ ID NO: 1; from about nucleobase 1400 to about nucleobase 3500 of SEQ ID NO: 1; or from about nucleobase 7500 to about nucleobase 8100 of SEQ ID NO: 1. In some preferred embodiments, a double-stranded oligonucleotide of the invention may a sense strand that is identical to an equal length portion within a nucleobase sequence corresponding to: from about nucleobase 1 to about nucleobase 8100 of SEQ ID NO: 1; from about nucleobase 1 to about nucleobase 600 of SEQ ID NO: 1; from about nucleobase 1400 to about nucleobase 3500 of SEQ ID NO: 1; or from about nucleobase 7500 to about nucleobase 8100 of SEQ ID NO: 1. A double-stranded nucleotide of the invention may comprise an antisense strand and a sense strand as defined herein. Typically, the antisense strand and the sense strand are at least partially complementary to each other. Thus, the antisense strand may be complementary to an equal length portion of a PSD3 nucleic acid as described herein, and the sense strand may be identical to the same equal length portion of the PSD3 nucleic acid, or identical to region which overlaps with said equal length portion. Said overlap may be at least 5, at least 10, at least 15, at least 16, at least 17, at least 18, at least 19, at least 20, at least 21, at least 22, at least 23 or more nucleobases. In particular, the invention provides a double-stranded oligonucleotide comprising an antisense strand and a sense strand, wherein: (i) the antisense strand comprises a nucleobase sequence which comprises or consists of a nucleobase sequence that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% complementary to an equal length portion of a PSD3 nucleic acid having the nucleobase sequence of SEQ ID NO: 1; and (ii) the sense strand comprises a nucleobase sequence which comprises or consists of a nucleobase sequence that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% identical to the same equal length portion of a PSD3 nucleic acid having the nucleobase sequence of SEQ ID NO: 1, or an overlapping region thereto. A double-stranded oligonucleotide of the invention may comprise: (i) an antisense strand that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% complementary to an equal length portion within a nucleobase sequence corresponding to from about nucleobase 1 to about nucleobase 9000 of SEQ ID NO: 1, preferably corresponding to from about nucleobase 1 to about nucleobase 8500 of SEQ ID NO: 1, more preferably corresponding to from about nucleobase 1 to about nucleobase 8250 of SEQ ID NO: 1, even more preferably corresponding to from about nucleobase 1 to about nucleobase 8100 of SEQ ID NO: 1; and (ii) a sense strand that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% identical the same equal length portion within a nucleobase sequence corresponding to from about nucleobase 1 to about nucleobase 9000 of SEQ ID NO: 1, preferably corresponding to from about nucleobase 1 to about nucleobase 8500 of SEQ ID NO: 1, more preferably corresponding to from about nucleobase 1 to about nucleobase 8250 of SEQ ID NO: 1, even more preferably corresponding to from about nucleobase 1 to about nucleobase 8100 of SEQ ID NO: 1, or an overlapping region thereto. In some preferred embodiments, a double-stranded oligonucleotide of the invention may comprise: (i) an antisense strand that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% complementary to an equal length portion within a nucleobase sequence corresponding to from about nucleobase 1 to about nucleobase 8100 of SEQ ID NO: 1; and (ii) a sense strand that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% identical to the same equal length portion within a nucleobase sequence corresponding to from about nucleobase 1 to about nucleobase 8100 of SEQ ID NO: 1, or an overlapping region thereto. A double-stranded oligonucleotide of the invention may comprise: (i) an antisense strand that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% complementary to an equal length portion within a nucleobase sequence corresponding to from about nucleobase 1 to about nucleobase 700 of SEQ ID NO: 1, preferably corresponding to from about nucleobase 1 to about nucleobase 650 of SEQ ID NO: 1, more preferably corresponding to from about nucleobase 1 to about nucleobase 600 of SEQ ID NO: 1; and (ii) a sense strand that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% identical to the same equal length portion within a nucleobase sequence corresponding to from about nucleobase 1 to about nucleobase 700 of SEQ ID NO: 1, preferably corresponding to from about nucleobase 1 to about nucleobase 650 of SEQ ID NO: 1, more preferably corresponding to from about nucleobase 1 to about nucleobase 600 of SEQ ID NO: 1, or an overlapping region thereto. In some preferred embodiments, a double- stranded oligonucleotide of the invention may comprise: (i) an antisense strand that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% complementary to an equal length portion within a nucleobase sequence corresponding to from about nucleobase 1 to about nucleobase 600 of SEQ ID NO: 1; and (ii) a sense strand that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% identical to the same equal length portion within a nucleobase sequence corresponding to from about nucleobase 1 to about nucleobase 600 of SEQ ID NO: 1, or an overlapping region thereto. A double-stranded oligonucleotide of the invention may comprise: (i) an antisense strand that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% complementary to an equal length portion within a nucleobase sequence corresponding to from about nucleobase 1000 to about nucleobase 4000 of SEQ ID NO: 1, preferably corresponding to from about nucleobase 1200 to about nucleobase 4000 of SEQ ID NO: 1, more preferably corresponding to from about nucleobase 1200 to about nucleobase 3750 of SEQ ID NO: 1, yet more preferably corresponding to from about nucleobase 1200 to about nucleobase 3500 of SEQ ID NO: 1, even yet more preferably corresponding to from about nucleobase 1400 to about nucleobase 3500 of SEQ ID NO: 1; and (ii) a sense strand that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% identical to the same equal length portion within a nucleobase sequence corresponding to from about nucleobase 1000 to about nucleobase 4000 of SEQ ID NO: 1, preferably corresponding to from about nucleobase 1200 to about nucleobase 4000 of SEQ ID NO: 1, more preferably corresponding to from about nucleobase 1200 to about nucleobase 3750 of SEQ ID NO: 1, yet more preferably corresponding to from about nucleobase 1200 to about nucleobase 3500 of SEQ ID NO: 1, even yet more preferably corresponding to from about nucleobase 1400 to about nucleobase 3500 of SEQ ID NO: 1, or an overlapping region thereto. In some preferred embodiments, a double-stranded oligonucleotide of the invention may comprise: (i) an antisense strand that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% complementary to an equal length portion within a nucleobase sequence corresponding to from about nucleobase 1400 to about nucleobase 3500 of SEQ ID NO: 1; and (ii) a sense strand that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% identical to the same equal length portion within a nucleobase sequence corresponding to from about nucleobase 1400 to about nucleobase 3500 of SEQ ID NO: 1, or an overlapping region thereto. A double-stranded oligonucleotide of the invention may comprise: (i) an antisense strand that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% complementary to an equal length portion within a nucleobase sequence corresponding to from about nucleobase 7000 to about nucleobase 9000 of SEQ ID NO: 1, preferably corresponding to from about nucleobase 7000 to about nucleobase 8500 of SEQ ID NO: 1, more preferably corresponding to from about nucleobase 7250 to about nucleobase 8500 of SEQ ID NO: 1, yet more preferably corresponding to from about nucleobase 7250 to about nucleobase 8100 of SEQ ID NO: 1, even yet more preferably corresponding to from about nucleobase 7500 to about nucleobase 8100 of SEQ ID NO: 1; and (ii) a sense strand that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% identical to the same equal length portion within a nucleobase sequence corresponding to from about nucleobase 7000 to about nucleobase 9000 of SEQ ID NO: 1, preferably corresponding to from about nucleobase 7000 to about nucleobase 8500 of SEQ ID NO: 1, more preferably corresponding to from about nucleobase 7250 to about nucleobase 8500 of SEQ ID NO: 1, yet more preferably corresponding to from about nucleobase 7250 to about nucleobase 8100 of SEQ ID NO: 1, even yet more preferably corresponding to from about nucleobase 7500 to about nucleobase 8100 of SEQ ID NO: 1, or an overlapping region thereto. In some preferred embodiments, a double-stranded oligonucleotide of the invention may comprise: (i) an antisense strand that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% complementary to an equal length portion within a nucleobase sequence corresponding to from about nucleobase 7500 to about nucleobase 8100 of SEQ ID NO: 1; and (ii) a sense strand that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% identical to the same equal length portion within a nucleobase sequence corresponding to from about nucleobase 7500 to about nucleobase 8100 of SEQ ID NO: 1, or an overlapping region thereto. In some preferred embodiments, a double-stranded oligonucleotide of the invention may comprise: (i) an antisense strand that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% complementary to an equal length portion within a nucleobase sequence corresponding to: from about nucleobase 1 to about nucleobase 8100 of SEQ ID NO: 1; from about nucleobase 1 to about nucleobase 600 of SEQ ID NO: 1; from about nucleobase 1400 to about nucleobase 3500 of SEQ ID NO: 1; or from about nucleobase 7500 to about nucleobase 8100 of SEQ ID NO: 1; and (ii) a sense strand that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% identical to the same equal length portion within a nucleobase sequence corresponding to: from about nucleobase 1 to about nucleobase 8100 of SEQ ID NO: 1; from about nucleobase 1 to about nucleobase 600 of SEQ ID NO: 1; from about nucleobase 1400 to about nucleobase 3500 of SEQ ID NO: 1; or from about nucleobase 7500 to about nucleobase 8100 of SEQ ID NO: 1, or an overlapping region thereto. In some preferred embodiments, a double-stranded oligonucleotide of the invention may comprise: (i) an antisense strand that is at least 90% complementary to an equal length portion within a nucleobase sequence corresponding to: from about nucleobase 1 to about nucleobase 8100 of SEQ ID NO: 1; from about nucleobase 1 to about nucleobase 600 of SEQ ID NO: 1; from about nucleobase 1400 to about nucleobase 3500 of SEQ ID NO: 1; or from about nucleobase 7500 to about nucleobase 8100 of SEQ ID NO: 1; and (ii) a sense strand that is at least 90% identical to the same equal length portion within a nucleobase sequence corresponding to: from about nucleobase 1 to about nucleobase 8100 of SEQ ID NO: 1; from about nucleobase 1 to about nucleobase 600 of SEQ ID NO: 1; from about nucleobase 1400 to about nucleobase 3500 of SEQ ID NO: 1; or from about nucleobase 7500 to about nucleobase 8100 of SEQ ID NO: 1, or an overlapping region thereto. In some preferred embodiments, a double-stranded oligonucleotide of the invention may comprise: (i) an antisense strand that is at least 95% complementary to an equal length portion within a nucleobase sequence corresponding to: from about nucleobase 1 to about nucleobase 8100 of SEQ ID NO: 1; from about nucleobase 1 to about nucleobase 600 of SEQ ID NO: 1; from about nucleobase 1400 to about nucleobase 3500 of SEQ ID NO: 1; or from about nucleobase 7500 to about nucleobase 8100 of SEQ ID NO: 1; and (ii) a sense strand that is at least 95% identical to the same equal length portion within a nucleobase sequence corresponding to: from about nucleobase 1 to about nucleobase 8100 of SEQ ID NO: 1; from about nucleobase 1 to about nucleobase 600 of SEQ ID NO: 1; from about nucleobase 1400 to about nucleobase 3500 of SEQ ID NO: 1; or from about nucleobase 7500 to about nucleobase 8100 of SEQ ID NO: 1 or an overlapping region thereto. In some preferred embodiments, a double-stranded oligonucleotide of the invention may comprise: (i) an antisense strand that is at least 99% complementary to an equal length portion within a nucleobase sequence corresponding to: from about nucleobase 1 to about nucleobase 8100 of SEQ ID NO: 1; from about nucleobase 1 to about nucleobase 600 of SEQ ID NO: 1; from about nucleobase 1400 to about nucleobase 3500 of SEQ ID NO: 1; or from about nucleobase 7500 to about nucleobase 8100 of SEQ ID NO: 1; and (ii) a sense strand that is at least 99% identical to the same equal length portion within a nucleobase sequence corresponding to: from about nucleobase 1 to about nucleobase 8100 of SEQ ID NO: 1; from about nucleobase 1 to about nucleobase 600 of SEQ ID NO: 1; from about nucleobase 1400 to about nucleobase 3500 of SEQ ID NO: 1; or from about nucleobase 7500 to about nucleobase 8100 of SEQ ID NO: 1, or an overlapping region thereto. In some preferred embodiments, a double-stranded oligonucleotide of the invention may comprise: (i) an antisense strand that is complementary to an equal length portion within a nucleobase sequence corresponding to: from about nucleobase 1 to about nucleobase 8100 of SEQ ID NO: 1; from about nucleobase 1 to about nucleobase 600 of SEQ ID NO: 1; from about nucleobase 1400 to about nucleobase 3500 of SEQ ID NO: 1; or from about nucleobase 7500 to about nucleobase 8100 of SEQ ID NO: 1; and (ii) a sense strand that is identical to the same equal length portion within a nucleobase sequence corresponding to: from about nucleobase 1 to about nucleobase 8100 of SEQ ID NO: 1; from about nucleobase 1 to about nucleobase 600 of SEQ ID NO: 1; from about nucleobase 1400 to about nucleobase 3500 of SEQ ID NO: 1; or from about nucleobase 7500 to about nucleobase 8100 of SEQ ID NO: 1, or an overlapping region thereto. Exemplary unmodified nucleobase sequences for antisense (guide) strands of double-stranded oligonucleotides of the invention are given in column 4 of Table 1, with the corresponding sequence identifier in column 5. The compound number is shown in column 1. The position of the left-most (5'-most) residue of the corresponding nucleobase sequence in the PSD3 transcript of SEQ ID NO: 1 which is complementary to a given antisense nucleobase sequence is given in column 2. The position of the right-most (3'-most) residue of the corresponding nucleobase sequence in the PSD3 transcript of SEQ ID NO: 1 which is complementary to a given antisense nucleobase sequence is given in column 3. Exemplary modified nucleobase sequences for antisense (guide) strands of double-stranded oligonucleotides of the invention are given in column 2 of Table 3, with the corresponding sequence identifier in column 3. The compound number is shown in column 1. Preferred exemplary unmodified nucleobase sequences for antisense (guide) strands of double-stranded oligonucleotides of the invention are given in column 4 of Table 2, with the corresponding sequence identifier in column 5. The compound number is shown in column 1. The position of the left-most (5'-most) residue of the corresponding nucleobase sequence in the PSD3 transcript of SEQ ID NO: 1 which is complementary to a given antisense nucleobase sequence is given in column 2. The position of the right-most (3'-most) residue of the corresponding nucleobase sequence in the PSD3 transcript of SEQ ID NO: 1 which is complementary to a given antisense nucleobase sequence is given in column 3. Preferred exemplary modified nucleobase sequences for antisense (guide) strands of double-stranded oligonucleotides of the invention are given in column 2 of Table 4, with the corresponding sequence identifier in column 3. The compound number is shown in column 1. The nucleobase sequence of the antisense strand may comprise or consist of a nucleobase sequence that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% identical to any of SEQ ID NOs: 2, 3, 6, 7, 10, 11, 14, 15, 18, 19, 22, 23, 26, 27, 30, 31, 34, 35, 38, 39, 42, 43, 46, 47, 50, 51, 54, 55, 58, 59, 62, 63, 66, 67, 70, 71, 74, 75, 78, 79, 82, 83, 86, 87, 90, 91, 94, 95, 98, 99, 102, 103, 106, 107, 110, 111, 114, 115, 118, 119, 122, 123, 126, 127, 130, 131, 134, 135, 138, 139, 142, 143, 146, 147, 150, 151, 154, 155, 158, 159, 162, 163, 166, 167, 170, 171, 174, 175, 178, 179, 182, 183, 186, 187, 190, 191, 194, 195, 198, 199, 202, 203, 206, 207, 210, 211, 214, 215, 218, 219, 222, 223, 226, 227, 230, 231, 234, 235, 238, 239, 242, 243, 246, 247, 250, 251, 254, 255, 258, 259, 262, 263, 266, 267, 270, 271, 274, 275, 278, 279, 282, 283, 286, 287, 290, 291, 294, 295, 298, 299, 302, 303, 306, 307, 310, 311, 314, 315, 318, 319, 322, 323, 326, 327, 330, 331, 334, 335, 338, 339, 342, 343, 346, 347, 350, 351, 354, 355, 358, 359, 362, 363, 366, 367, 370, 371, 374, 375, 378, 379, 382, 383, 386, 387, 390, 391, 394, 395, 398, 399, 402, 403, 406, 407, 410, 411, 414, 415, 418, 419, 422, 423, 426, 427, 430, 431, 434, 435, 438, 439, 442, 443, 446, 447, 450, 451, 454, 455, 458, 459, 462, 463, 466, 467, 470, 471, 474, 475, 478, 479, 482, 483, 486, 487, 490, 491, 494, 495, 498, 499, 502, 503, 506, 507, 510, 511, 514, 515, 518, 519, 522, 523, 526, 527, 530, 531, 534, 535, 538, 539, 542, 543, 546, 547, 550, 551, 554, 555, 558, 559, 562, 563, 566, 567, 570, 571, 574, 575, 578, 579, 582, 583, 586, 587, 590, 591, 594, 595, 598, 599, 602, 603, 606, 607, 610, 611, 614, 615, 618, 619, 622, 623, 626, 627, 630, 631, 634, 635, 638, 639, 642, 643, 646, 647, 650, 651, 654, 655, 658, 659, 662, 663, 666, 667, 670, 671, 674, 675, 678, 679, 682, 683, 686, 687, 690, 691, 694, 695, 698, 699, 702, 703, 706, 707, 710, 711, 714, 715, 718, 719, 722, 723, 726, 727, 730, 731, 734, 735, 738, 739, 742, 743, 746, 747, 750, 751, 754, 755, 758, 759, 762, 763, 766, 767, 770, 771, 774, 775, 778, 779, 782, 783, 786, 787, 790, 791, 794, 795, 798, 799, 802, 803, 806, 807, 810, 811, 814, 815, 818, 819, 822, 823, 826, 827, 830, 831, 834, 835, 838, 839, 842, 843, 846, 847, 850, 851, 854, 855, 858, 859, 862, 863, 866, 867, 870, 871, 874, 875, 878, 879, 882, 883, 886, 887, 890, 891, 894, 895, 898, 899, 902, 903, 906, 907, 910, 911, 914, 915, 918, 919, 922, 923, 926, 927, 930, 931, 934, 935, 938, 939, 942, 943, 946, 947, 950, 951, 954, 955, 958, 959, 962, 963, 966, 967, 970, 971, 974, 975, 978, 979, 982, 983, 986, 987, 990, 991, 994, 995, 998, 999, 1002, 1003, 1006, 1007, 1010, 1011, 1014, 1015, 1018, 1019, 1022, 1023, 1026, 1027, 1030, 1031, 1034, 1035, 1038, 1039, 1042, 1043, 1046, 1047, 1050, 1051, 1054, 1055, 1058, 1059, 1062, 1063, 1066, 1067, 1070, 1071, 1074, 1075, 1078, 1079, 1082, 1083, 1086, 1087, 1090, 1091, 1094, 1095, 1098, 1099, 1102, 1103, 1106, 1107, 1110, 1111, 1114, 1115, 1118, 1119, 1122, 1123, 1126, 1127, 1130, 1131, 1134, 1135, 1138, 1139, 1142, 1143, 1146, 1147, 1150, 1151, 1154, 1155, 1158, 1159, 1162, 1163, 1166, 1167, 1170, 1171, 1174, 1175, 1178, 1179, 1182, 1183, 1186, 1187, 1190, 1191, 1194, 1195, 1198, 1199, 1202, 1203, 1206, 1207, 1210, 1211, 1214, 1215, 1218, 1219, 1222, 1223, 1226, 1227, 1230, 1231, 1234, 1235, 1238, 1239, 1242, 1243, 1246, 1247, 1250, 1251, 1254, 1255, 1258, 1259, 1262, 1263, 1266, 1267, 1270, 1271, 1274, 1275, 1278, 1279, 1282, 1283, 1286, 1287, 1290, 1291, 1294, 1295, 1298, 1299, 1302, 1303, 1306, 1307, 1310, 1311, 1314, 1315, 1318, 1319, 1322, 1323, 1326, 1327, 1330, 1331, 1334, 1335, 1338, 1339, 1342, 1343, 1346, 1347, 1350, 1351, 1354, 1355, 1358, 1359, 1362, 1363, 1366, 1367, 1370, 1371, 1374, 1375, 1378, 1379, 1382, 1383, 1386, 1387, 1390, 1391, 1394, 1395, 1398, 1399, 1402, 1403, 1406, 1407, 1410, 1411, 1414, 1415, 1418, 1419, 1422, 1423, 1426, 1427, 1430, 1431, 1434, 1435, 1438, 1439, 1442, 1443, 1446, 1447, 1450, 1451, 1454, 1455, 1458, 1459, 1462, 1463, 1466, 1467, 1470, 1471, 1474, 1475, 1478, 1479, 1482, 1483, 1486, 1487, 1490, 1491, 1494, 1495, 1498, 1499, 1502, 1503, 1506, 1507, 1510, 1511, 1514, 1515, 1518, 1519, 1522, 1523, 1526, 1527, 1530, 1531, 1534, 1535, 1538, 1539, 1542, 1543, 1546, 1547, 1550, 1551, 1554, 1555, 1558, 1559, 1562, 1563, 1566, 1567, 1570, 1571, 1574, 1575, 1578, 1579, 1582, 1583, 1586, 1587, 1590, 1591, 1594, 1595, 1598, 1599, 1602, 1603, 1606, 1607, 1610, 1611, 1614, 1615, 1618, 1619, 1622, 1623, 1626, 1627, 1630, 1631, 1634, 1635, 1638, 1639, 1642, 1643, 1646, 1647, 1650, 1651, 1654, 1655, 1658, 1659, 1662, 1663, 1666, 1667, 1670, 1671, 1674, 1675, 1678, 1679, 1682, 1683, 1686, 1687, 1690, 1691, 1694, 1695, 1698, 1699, 1702, 1703, 1706, 1707, 1710, 1711, 1714, 1715, 1718, 1719, 1722, 1723, 1726, 1727, 1730, 1731, 1734, 1735, 1738, 1739, 1742, 1743, 1746, 1747, 1750, 1751, 1754, 1755, 1758, 1759, 1762, 1763, 1766, 1767, 1770, 1771, 1774, 1775, 1778, 1779, 1782, 1783, 1786, 1787, 1790, 1791, 1794, 1795, 1798, 1799, 1802, 1803, 1806, 1807, 1810, 1811, 1814, 1815, 1818, 1819, 1822, 1823, 1826, 1827, 1830, 1831, 1834, 1835, 1838, 1839, 1842, 1843, 1846, 1847, 1850, 1851, 1854, 1855, 1858, 1859, 1862, 1863, 1866, 1867, 1870, 1871, 1874, 1875, 1878, 1879, 1882, 1883, 1886, 1887, 1890, 1891, 1894, 1895, 1898, 1899, 1902, 1903, 1906, 1907, 1910, 1911, 1914, 1915, 1918 or 1919. The nucleobase sequence of the antisense strand may comprise or consist of a nucleobase sequence that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% identical to any of SEQ ID NOs: 2, 6, 10, 14, 18, 22, 26, 30, 34, 38, 42, 46, 50, 54, 58, 62, 66, 70, 74, 78, 82, 86, 90, 94, 98, 102, 106, 110, 114, 118, 122, 126, 130, 134, 138, 142, 146, 150, 154, 158, 162, 166, 170, 174, 178, 182, 186, 190, 194, 198, 202, 206, 210, 214, 218, 222, 226, 230, 234, 238, 242, 246, 250, 254, 258, 262, 266, 270, 274, 278, 282, 286, 290, 294, 298, 302, 306, 310, 314, 318, 322, 326, 330, 334, 338, 342, 346, 350, 354, 358, 362, 366, 370, 374, 378, 382, 386, 390, 394, 398, 402, 406, 410, 414, 418, 422, 426, 430, 434, 438, 442, 446, 450, 454, 458, 462, 466, 470, 474, 478, 482, 486, 490, 494, 498, 502, 506, 510, 514, 518, 522, 526, 530, 534, 538, 542, 546, 550, 554, 558, 562, 566, 570, 574, 578, 582, 586, 590, 594, 598, 602, 606, 610, 614, 618, 622, 626, 630, 634, 638, 642, 646, 650, 654, 658, 662, 666, 670, 674, 678, 682, 686, 690, 694, 698, 702, 706, 710, 714, 718, 722, 726, 730, 734, 738, 742, 746, 750, 754, 758, 762, 766, 770, 774, 778, 782, 786, 790, 794, 798, 802, 806, 810, 814, 818, 822, 826, 830, 834, 838, 842, 846, 850, 854, 858, 862, 866, 870, 874, 878, 882, 886, 890, 894, 898, 902, 906, 910, 914, 918, 922, 926, 930, 934, 938, 942, 946, 950, 954, 958, 962, 966, 970, 974, 978, 982, 986, 990, 994, 998, 1002, 1006, 1010, 1014, 1018, 1022, 1026, 1030, 1034, 1038, 1042, 1046, 1050, 1054, 1058, 1062, 1066, 1070, 1074, 1078, 1082, 1086, 1090, 1094, 1098, 1102, 1106, 1110, 1114, 1118, 1122, 1126, 1130, 1134, 1138, 1142, 1146, 1150, 1154, 1158, 1162, 1166, 1170, 1174, 1178, 1182, 1186, 1190, 1194, 1198, 1202, 1206, 1210, 1214, 1218, 1222, 1226, 1230, 1234, 1238, 1242, 1246, 1250, 1254, 1258, 1262, 1266, 1270, 1274, 1278, 1282, 1286, 1290, 1294, 1298, 1302, 1306, 1310, 1314, 1318, 1322, 1326, 1330, 1334, 1338, 1342, 1346, 1350, 1354, 1358, 1362, 1366, 1370, 1374, 1378, 1382, 1386, 1390, 1394, 1398, 1402, 1406, 1410, 1414, 1418, 1422, 1426, 1430, 1434, 1438, 1442, 1446, 1450, 1454, 1458, 1462, 1466, 1470, 1474, 1478, 1482, 1486, 1490, 1494, 1498, 1502, 1506, 1510, 1514, 1518, 1522, 1526, 1530, 1534, 1538, 1542, 1546, 1550, 1554, 1558, 1562, 1566, 1570, 1574, 1578, 1582, 1586, 1590, 1594, 1598, 1602, 1606, 1610, 1614, 1618, 1622, 1626, 1630, 1634, 1638, 1642, 1646, 1650, 1654, 1658, 1662, 1666, 1670, 1674, 1678, 1682, 1686, 1690, 1694, 1698, 1702, 1706, 1710, 1714, 1718, 1722, 1726, 1730, 1734, 1738, 1742, 1746, 1750, 1754, 1758, 1762, 1766, 1770, 1774, 1778, 1782, 1786, 1790, 1794, 1798, 1802, 1806, 1810, 1814, 1818, 1822, 1826, 1830, 1834, 1838, 1842, 1846, 1850, 1854, 1858, 1862, 1866, 1870, 1874, 1878, 1882, 1886, 1890, 1894, 1898, 1902, 1906, 1910, 1914 or 1918. The nucleobase sequence of the antisense strand may comprise or consist of a nucleobase sequence that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% identical to any of SEQ ID NOs: 3, 7, 11, 15, 19, 23, 27, 31, 35, 39, 43, 47, 51, 55, 59, 63, 67, 71, 75, 79, 83, 87, 91, 95, 99, 103, 107, 111, 115, 119, 123, 127, 131, 135, 139, 143, 147, 151, 155, 159, 163, 167, 171, 175, 179, 183, 187, 191, 195, 199, 203, 207, 211, 215, 219, 223, 227, 231, 235, 239, 243, 247, 251, 255, 259, 263, 267, 271, 275, 279, 283, 287, 291, 295, 299, 303, 307, 311, 315, 319, 323, 327, 331, 335, 339, 343, 347, 351, 355, 359, 363, 367, 371, 375, 379, 383, 387, 391, 395, 399, 403, 407, 411, 415, 419, 423, 427, 431, 435, 439, 443, 447, 451, 455, 459, 463, 467, 471, 475, 479, 483, 487, 491, 495, 499, 503, 507, 511, 515, 519, 523, 527, 531, 535, 539, 543, 547, 551, 555, 559, 563, 567, 571, 575, 579, 583, 587, 591, 595, 599, 603, 607, 611, 615, 619, 623, 627, 631, 635, 639, 643, 647, 651, 655, 659, 663, 667, 671, 675, 679, 683, 687, 691, 695, 699, 703, 707, 711, 715, 719, 723, 727, 731, 735, 739, 743, 747, 751, 755, 759, 763, 767, 771, 775, 779, 783, 787, 791, 795, 799, 803, 807, 811, 815, 819, 823, 827, 831, 835, 839, 843, 847, 851, 855, 859, 863, 867, 871, 875, 879, 883, 887, 891, 895, 899, 903, 907, 911, 915, 919, 923, 927, 931, 935, 939, 943, 947, 951, 955, 959, 963, 967, 971, 975, 979, 983, 987, 991, 995, 999, 1003, 1007, 1011, 1015, 1019, 1023, 1027, 1031, 1035, 1039, 1043, 1047, 1051, 1055, 1059, 1063, 1067, 1071, 1075, 1079, 1083, 1087, 1091, 1095, 1099, 1103, 1107, 1111, 1115, 1119, 1123, 1127, 1131, 1135, 1139, 1143, 1147, 1151, 1155, 1159, 1163, 1167, 1171, 1175, 1179, 1183, 1187, 1191, 1195, 1199, 1203, 1207, 1211, 1215, 1219, 1223, 1227, 1231, 1235, 1239, 1243, 1247, 1251, 1255, 1259, 1263, 1267, 1271, 1275, 1279, 1283, 1287, 1291, 1295, 1299, 1303, 1307, 1311, 1315, 1319, 1323, 1327, 1331, 1335, 1339, 1343, 1347, 1351, 1355, 1359, 1363, 1367, 1371, 1375, 1379, 1383, 1387, 1391, 1395, 1399, 1403, 1407, 1411, 1415, 1419, 1423, 1427, 1431, 1435, 1439, 1443, 1447, 1451, 1455, 1459, 1463, 1467, 1471, 1475, 1479, 1483, 1487, 1491, 1495, 1499, 1503, 1507, 1511, 1515, 1519, 1523, 1527, 1531, 1535, 1539, 1543, 1547, 1551, 1555, 1559, 1563, 1567, 1571, 1575, 1579, 1583, 1587, 1591, 1595, 1599, 1603, 1607, 1611, 1615, 1619, 1623, 1627, 1631, 1635, 1639, 1643, 1647, 1651, 1655, 1659, 1663, 1667, 1671, 1675, 1679, 1683, 1687, 1691, 1695, 1699, 1703, 1707, 1711, 1715, 1719, 1723, 1727, 1731, 1735, 1739, 1743, 1747, 1751, 1755, 1759, 1763, 1767, 1771, 1775, 1779, 1783, 1787, 1791, 1795, 1799, 1803, 1807, 1811, 1815, 1819, 1823, 1827, 1831, 1835, 1839, 1843, 1847, 1851, 1855, 1859, 1863, 1867, 1871, 1875, 1879, 1883, 1887, 1891, 1895, 1899, 1903, 1907, 1911, 1915 or 1919. In some preferred embodiments, the nucleobase sequence of the antisense strand may comprise or consist of a nucleobase sequence that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% identical to any of SEQ ID NOs: 34, 35, 54, 55, 58, 59, 142, 143, 158, 159, 250, 251, 262, 263, 282, 283, 286, 287, 390, 391, 398, 399, 426, 427, 470, 471, 478, 479, 494, 495, 502, 503, 522, 523, 566, 567, 574, 575, 586, 587, 606, 607, 618, 619, 626, 627, 654, 655, 666, 667, 678, 679, 694, 695, 698, 699, 722, 723, 730, 731, 742, 743, 778, 779, 802, 803, 822, 823, 830, 831, 842, 843, 846, 847, 858, 859, 862, 863, 866, 867, 870, 871, 874, 875, 878, 879, 886, 887, 906, 907, 914, 915, 946, 947, 954, 955, 970, 971, 978, 979, 1006, 1007, 1018, 1019, 1022, 1023, 1026, 1027, 1034, 1035, 1038, 1039, 1042, 1043, 1058, 1059, 1082, 1083, 1086, 1087, 1102, 1103, 1118, 1119, 1126, 1127, 1142, 1143, 1146, 1147, 1150, 1151, 1154, 1155, 1158, 1159, 1182, 1183, 1186, 1187, 1190, 1191, 1210, 1211, 1214, 1215, 1254, 1255, 1270, 1271, 1274, 1275, 1278, 1279, 1282, 1283, 1294, 1295, 1298, 1299, 1302, 1303, 1310, 1311, 1330, 1331, 1334, 1335, 1346, 1347, 1354, 1355, 1358, 1359, 1362, 1363, 1366, 1367, 1602, 1603, 1614, 1615, 1618, 1619, 1626, 1627, 1630 or 1631. In some preferred embodiments, the nucleobase sequence of the antisense strand may comprise or consist of a nucleobase sequence that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% identical to any of SEQ ID NOs: 34, 54, 58, 142, 158, 250, 262, 282, 286, 390, 398, 426, 470, 478, 494, 502, 522, 566, 574, 586, 606, 618, 626, 654, 666, 678, 694, 698, 722, 730, 742, 778, 802, 822, 830, 842, 846, 858, 862, 866, 870, 874, 878, 886, 906, 914, 946, 954, 970, 978, 1006, 1018, 1022, 1026, 1034, 1038, 1042, 1058, 1082, 1086, 1102, 1118, 1126, 1142, 1146, 1150, 1154, 1158, 1182, 1186, 1190, 1210, 1214, 1254, 1270, 1274, 1278, 1282, 1294, 1298, 1302, 1310, 1330, 1334, 1346, 1354, 1358, 1362, 1366, 1602, 1614, 1618, 1626 or 1630. In some particularly preferred embodiments, the nucleobase sequence of the antisense strand may comprise or consist of a nucleobase sequence that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% identical to any of SEQ ID NOs: 35, 55, 59, 143, 159, 251, 263, 283, 287, 391, 399, 427, 471, 479, 495, 503, 523, 567, 575, 587, 607, 619, 627, 655, 667, 679, 695, 699, 723, 731, 743, 779, 803, 823, 831, 843, 847, 859, 863, 867, 871, 875, 879, 887, 907, 915, 947, 955, 971, 979, 1007, 1019, 1023, 1027, 1035, 1039, 1043, 1059, 1083, 1087, 1103, 1119, 1127, 1143, 1147, 1151, 1155, 1159, 1183, 1187, 1191, 1211, 1215, 1255, 1271, 1275, 1279, 1283, 1295, 1299, 1303, 1311, 1331, 1335, 1347, 1355, 1359, 1363, 1367, 1603, 1615, 1619, 1627 or 1631. The nucleobase sequence of the antisense strand may comprise or consist of a nucleobase sequence that is at least 90% identical to any of SEQ ID NOs: 2, 3, 6, 7, 10, 11, 14, 15, 18, 19, 22, 23, 26, 27, 30, 31, 34, 35, 38, 39, 42, 43, 46, 47, 50, 51, 54, 55, 58, 59, 62, 63, 66, 67, 70, 71, 74, 75, 78, 79, 82, 83, 86, 87, 90, 91, 94, 95, 98, 99, 102, 103, 106, 107, 110, 111, 114, 115, 118, 119, 122, 123, 126, 127, 130, 131, 134, 135, 138, 139, 142, 143, 146, 147, 150, 151, 154, 155, 158, 159, 162, 163, 166, 167, 170, 171, 174, 175, 178, 179, 182, 183, 186, 187, 190, 191, 194, 195, 198, 199, 202, 203, 206, 207, 210, 211, 214, 215, 218, 219, 222, 223, 226, 227, 230, 231, 234, 235, 238, 239, 242, 243, 246, 247, 250, 251, 254, 255, 258, 259, 262, 263, 266, 267, 270, 271, 274, 275, 278, 279, 282, 283, 286, 287, 290, 291, 294, 295, 298, 299, 302, 303, 306, 307, 310, 311, 314, 315, 318, 319, 322, 323, 326, 327, 330, 331, 334, 335, 338, 339, 342, 343, 346, 347, 350, 351, 354, 355, 358, 359, 362, 363, 366, 367, 370, 371, 374, 375, 378, 379, 382, 383, 386, 387, 390, 391, 394, 395, 398, 399, 402, 403, 406, 407, 410, 411, 414, 415, 418, 419, 422, 423, 426, 427, 430, 431, 434, 435, 438, 439, 442, 443, 446, 447, 450, 451, 454, 455, 458, 459, 462, 463, 466, 467, 470, 471, 474, 475, 478, 479, 482, 483, 486, 487, 490, 491, 494, 495, 498, 499, 502, 503, 506, 507, 510, 511, 514, 515, 518, 519, 522, 523, 526, 527, 530, 531, 534, 535, 538, 539, 542, 543, 546, 547, 550, 551, 554, 555, 558, 559, 562, 563, 566, 567, 570, 571, 574, 575, 578, 579, 582, 583, 586, 587, 590, 591, 594, 595, 598, 599, 602, 603, 606, 607, 610, 611, 614, 615, 618, 619, 622, 623, 626, 627, 630, 631, 634, 635, 638, 639, 642, 643, 646, 647, 650, 651, 654, 655, 658, 659, 662, 663, 666, 667, 670, 671, 674, 675, 678, 679, 682, 683, 686, 687, 690, 691, 694, 695, 698, 699, 702, 703, 706, 707, 710, 711, 714, 715, 718, 719, 722, 723, 726, 727, 730, 731, 734, 735, 738, 739, 742, 743, 746, 747, 750, 751, 754, 755, 758, 759, 762, 763, 766, 767, 770, 771, 774, 775, 778, 779, 782, 783, 786, 787, 790, 791, 794, 795, 798, 799, 802, 803, 806, 807, 810, 811, 814, 815, 818, 819, 822, 823, 826, 827, 830, 831, 834, 835, 838, 839, 842, 843, 846, 847, 850, 851, 854, 855, 858, 859, 862, 863, 866, 867, 870, 871, 874, 875, 878, 879, 882, 883, 886, 887, 890, 891, 894, 895, 898, 899, 902, 903, 906, 907, 910, 911, 914, 915, 918, 919, 922, 923, 926, 927, 930, 931, 934, 935, 938, 939, 942, 943, 946, 947, 950, 951, 954, 955, 958, 959, 962, 963, 966, 967, 970, 971, 974, 975, 978, 979, 982, 983, 986, 987, 990, 991, 994, 995, 998, 999, 1002, 1003, 1006, 1007, 1010, 1011, 1014, 1015, 1018, 1019, 1022, 1023, 1026, 1027, 1030, 1031, 1034, 1035, 1038, 1039, 1042, 1043, 1046, 1047, 1050, 1051, 1054, 1055, 1058, 1059, 1062, 1063, 1066, 1067, 1070, 1071, 1074, 1075, 1078, 1079, 1082, 1083, 1086, 1087, 1090, 1091, 1094, 1095, 1098, 1099, 1102, 1103, 1106, 1107, 1110, 1111, 1114, 1115, 1118, 1119, 1122, 1123, 1126, 1127, 1130, 1131, 1134, 1135, 1138, 1139, 1142, 1143, 1146, 1147, 1150, 1151, 1154, 1155, 1158, 1159, 1162, 1163, 1166, 1167, 1170, 1171, 1174, 1175, 1178, 1179, 1182, 1183, 1186, 1187, 1190, 1191, 1194, 1195, 1198, 1199, 1202, 1203, 1206, 1207, 1210, 1211, 1214, 1215, 1218, 1219, 1222, 1223, 1226, 1227, 1230, 1231, 1234, 1235, 1238, 1239, 1242, 1243, 1246, 1247, 1250, 1251, 1254, 1255, 1258, 1259, 1262, 1263, 1266, 1267, 1270, 1271, 1274, 1275, 1278, 1279, 1282, 1283, 1286, 1287, 1290, 1291, 1294, 1295, 1298, 1299, 1302, 1303, 1306, 1307, 1310, 1311, 1314, 1315, 1318, 1319, 1322, 1323, 1326, 1327, 1330, 1331, 1334, 1335, 1338, 1339, 1342, 1343, 1346, 1347, 1350, 1351, 1354, 1355, 1358, 1359, 1362, 1363, 1366, 1367, 1370, 1371, 1374, 1375, 1378, 1379, 1382, 1383, 1386, 1387, 1390, 1391, 1394, 1395, 1398, 1399, 1402, 1403, 1406, 1407, 1410, 1411, 1414, 1415, 1418, 1419, 1422, 1423, 1426, 1427, 1430, 1431, 1434, 1435, 1438, 1439, 1442, 1443, 1446, 1447, 1450, 1451, 1454, 1455, 1458, 1459, 1462, 1463, 1466, 1467, 1470, 1471, 1474, 1475, 1478, 1479, 1482, 1483, 1486, 1487, 1490, 1491, 1494, 1495, 1498, 1499, 1502, 1503, 1506, 1507, 1510, 1511, 1514, 1515, 1518, 1519, 1522, 1523, 1526, 1527, 1530, 1531, 1534, 1535, 1538, 1539, 1542, 1543, 1546, 1547, 1550, 1551, 1554, 1555, 1558, 1559, 1562, 1563, 1566, 1567, 1570, 1571, 1574, 1575, 1578, 1579, 1582, 1583, 1586, 1587, 1590, 1591, 1594, 1595, 1598, 1599, 1602, 1603, 1606, 1607, 1610, 1611, 1614, 1615, 1618, 1619, 1622, 1623, 1626, 1627, 1630, 1631, 1634, 1635, 1638, 1639, 1642, 1643, 1646, 1647, 1650, 1651, 1654, 1655, 1658, 1659, 1662, 1663, 1666, 1667, 1670, 1671, 1674, 1675, 1678, 1679, 1682, 1683, 1686, 1687, 1690, 1691, 1694, 1695, 1698, 1699, 1702, 1703, 1706, 1707, 1710, 1711, 1714, 1715, 1718, 1719, 1722, 1723, 1726, 1727, 1730, 1731, 1734, 1735, 1738, 1739, 1742, 1743, 1746, 1747, 1750, 1751, 1754, 1755, 1758, 1759, 1762, 1763, 1766, 1767, 1770, 1771, 1774, 1775, 1778, 1779, 1782, 1783, 1786, 1787, 1790, 1791, 1794, 1795, 1798, 1799, 1802, 1803, 1806, 1807, 1810, 1811, 1814, 1815, 1818, 1819, 1822, 1823, 1826, 1827, 1830, 1831, 1834, 1835, 1838, 1839, 1842, 1843, 1846, 1847, 1850, 1851, 1854, 1855, 1858, 1859, 1862, 1863, 1866, 1867, 1870, 1871, 1874, 1875, 1878, 1879, 1882, 1883, 1886, 1887, 1890, 1891, 1894, 1895, 1898, 1899, 1902, 1903, 1906, 1907, 1910, 1911, 1914, 1915, 1918 or 1919. The nucleobase sequence of the antisense strand may comprise or consist of a nucleobase sequence that is at least 90% identical to any of SEQ ID NOs: 2, 6, 10, 14, 18, 22, 26, 30, 34, 38, 42, 46, 50, 54, 58, 62, 66, 70, 74, 78, 82, 86, 90, 94, 98, 102, 106, 110, 114, 118, 122, 126, 130, 134, 138, 142, 146, 150, 154, 158, 162, 166, 170, 174, 178, 182, 186, 190, 194, 198, 202, 206, 210, 214, 218, 222, 226, 230, 234, 238, 242, 246, 250, 254, 258, 262, 266, 270, 274, 278, 282, 286, 290, 294, 298, 302, 306, 310, 314, 318, 322, 326, 330, 334, 338, 342, 346, 350, 354, 358, 362, 366, 370, 374, 378, 382, 386, 390, 394, 398, 402, 406, 410, 414, 418, 422, 426, 430, 434, 438, 442, 446, 450, 454, 458, 462, 466, 470, 474, 478, 482, 486, 490, 494, 498, 502, 506, 510, 514, 518, 522, 526, 530, 534, 538, 542, 546, 550, 554, 558, 562, 566, 570, 574, 578, 582, 586, 590, 594, 598, 602, 606, 610, 614, 618, 622, 626, 630, 634, 638, 642, 646, 650, 654, 658, 662, 666, 670, 674, 678, 682, 686, 690, 694, 698, 702, 706, 710, 714, 718, 722, 726, 730, 734, 738, 742, 746, 750, 754, 758, 762, 766, 770, 774, 778, 782, 786, 790, 794, 798, 802, 806, 810, 814, 818, 822, 826, 830, 834, 838, 842, 846, 850, 854, 858, 862, 866, 870, 874, 878, 882, 886, 890, 894, 898, 902, 906, 910, 914, 918, 922, 926, 930, 934, 938, 942, 946, 950, 954, 958, 962, 966, 970, 974, 978, 982, 986, 990, 994, 998, 1002, 1006, 1010, 1014, 1018, 1022, 1026, 1030, 1034, 1038, 1042, 1046, 1050, 1054, 1058, 1062, 1066, 1070, 1074, 1078, 1082, 1086, 1090, 1094, 1098, 1102, 1106, 1110, 1114, 1118, 1122, 1126, 1130, 1134, 1138, 1142, 1146, 1150, 1154, 1158, 1162, 1166, 1170, 1174, 1178, 1182, 1186, 1190, 1194, 1198, 1202, 1206, 1210, 1214, 1218, 1222, 1226, 1230, 1234, 1238, 1242, 1246, 1250, 1254, 1258, 1262, 1266, 1270, 1274, 1278, 1282, 1286, 1290, 1294, 1298, 1302, 1306, 1310, 1314, 1318, 1322, 1326, 1330, 1334, 1338, 1342, 1346, 1350, 1354, 1358, 1362, 1366, 1370, 1374, 1378, 1382, 1386, 1390, 1394, 1398, 1402, 1406, 1410, 1414, 1418, 1422, 1426, 1430, 1434, 1438, 1442, 1446, 1450, 1454, 1458, 1462, 1466, 1470, 1474, 1478, 1482, 1486, 1490, 1494, 1498, 1502, 1506, 1510, 1514, 1518, 1522, 1526, 1530, 1534, 1538, 1542, 1546, 1550, 1554, 1558, 1562, 1566, 1570, 1574, 1578, 1582, 1586, 1590, 1594, 1598, 1602, 1606, 1610, 1614, 1618, 1622, 1626, 1630, 1634, 1638, 1642, 1646, 1650, 1654, 1658, 1662, 1666, 1670, 1674, 1678, 1682, 1686, 1690, 1694, 1698, 1702, 1706, 1710, 1714, 1718, 1722, 1726, 1730, 1734, 1738, 1742, 1746, 1750, 1754, 1758, 1762, 1766, 1770, 1774, 1778, 1782, 1786, 1790, 1794, 1798, 1802, 1806, 1810, 1814, 1818, 1822, 1826, 1830, 1834, 1838, 1842, 1846, 1850, 1854, 1858, 1862, 1866, 1870, 1874, 1878, 1882, 1886, 1890, 1894, 1898, 1902, 1906, 1910, 1914 or 1918. The nucleobase sequence of the antisense strand may comprise or consist of a nucleobase sequence that is at least 90% identical to any of SEQ ID NOs: 3, 7, 11, 15, 19, 23, 27, 31, 35, 39, 43, 47, 51, 55, 59, 63, 67, 71, 75, 79, 83, 87, 91, 95, 99, 103, 107, 111, 115, 119, 123, 127, 131, 135, 139, 143, 147, 151, 155, 159, 163, 167, 171, 175, 179, 183, 187, 191, 195, 199, 203, 207, 211, 215, 219, 223, 227, 231, 235, 239, 243, 247, 251, 255, 259, 263, 267, 271, 275, 279, 283, 287, 291, 295, 299, 303, 307, 311, 315, 319, 323, 327, 331, 335, 339, 343, 347, 351, 355, 359, 363, 367, 371, 375, 379, 383, 387, 391, 395, 399, 403, 407, 411, 415, 419, 423, 427, 431, 435, 439, 443, 447, 451, 455, 459, 463, 467, 471, 475, 479, 483, 487, 491, 495, 499, 503, 507, 511, 515, 519, 523, 527, 531, 535, 539, 543, 547, 551, 555, 559, 563, 567, 571, 575, 579, 583, 587, 591, 595, 599, 603, 607, 611, 615, 619, 623, 627, 631, 635, 639, 643, 647, 651, 655, 659, 663, 667, 671, 675, 679, 683, 687, 691, 695, 699, 703, 707, 711, 715, 719, 723, 727, 731, 735, 739, 743, 747, 751, 755, 759, 763, 767, 771, 775, 779, 783, 787, 791, 795, 799, 803, 807, 811, 815, 819, 823, 827, 831, 835, 839, 843, 847, 851, 855, 859, 863, 867, 871, 875, 879, 883, 887, 891, 895, 899, 903, 907, 911, 915, 919, 923, 927, 931, 935, 939, 943, 947, 951, 955, 959, 963, 967, 971, 975, 979, 983, 987, 991, 995, 999, 1003, 1007, 1011, 1015, 1019, 1023, 1027, 1031, 1035, 1039, 1043, 1047, 1051, 1055, 1059, 1063, 1067, 1071, 1075, 1079, 1083, 1087, 1091, 1095, 1099, 1103, 1107, 1111, 1115, 1119, 1123, 1127, 1131, 1135, 1139, 1143, 1147, 1151, 1155, 1159, 1163, 1167, 1171, 1175, 1179, 1183, 1187, 1191, 1195, 1199, 1203, 1207, 1211, 1215, 1219, 1223, 1227, 1231, 1235, 1239, 1243, 1247, 1251, 1255, 1259, 1263, 1267, 1271, 1275, 1279, 1283, 1287, 1291, 1295, 1299, 1303, 1307, 1311, 1315, 1319, 1323, 1327, 1331, 1335, 1339, 1343, 1347, 1351, 1355, 1359, 1363, 1367, 1371, 1375, 1379, 1383, 1387, 1391, 1395, 1399, 1403, 1407, 1411, 1415, 1419, 1423, 1427, 1431, 1435, 1439, 1443, 1447, 1451, 1455, 1459, 1463, 1467, 1471, 1475, 1479, 1483, 1487, 1491, 1495, 1499, 1503, 1507, 1511, 1515, 1519, 1523, 1527, 1531, 1535, 1539, 1543, 1547, 1551, 1555, 1559, 1563, 1567, 1571, 1575, 1579, 1583, 1587, 1591, 1595, 1599, 1603, 1607, 1611, 1615, 1619, 1623, 1627, 1631, 1635, 1639, 1643, 1647, 1651, 1655, 1659, 1663, 1667, 1671, 1675, 1679, 1683, 1687, 1691, 1695, 1699, 1703, 1707, 1711, 1715, 1719, 1723, 1727, 1731, 1735, 1739, 1743, 1747, 1751, 1755, 1759, 1763, 1767, 1771, 1775, 1779, 1783, 1787, 1791, 1795, 1799, 1803, 1807, 1811, 1815, 1819, 1823, 1827, 1831, 1835, 1839, 1843, 1847, 1851, 1855, 1859, 1863, 1867, 1871, 1875, 1879, 1883, 1887, 1891, 1895, 1899, 1903, 1907, 1911, 1915 or 1919. The nucleobase sequence of the antisense strand may comprise or consist of a nucleobase sequence that is at least 90% identical to any of SEQ ID NOs: 34, 35, 54, 55, 58, 59, 142, 143, 158, 159, 250, 251, 262, 263, 282, 283, 286, 287, 390, 391, 398, 399, 426, 427, 470, 471, 478, 479, 494, 495, 502, 503, 522, 523, 566, 567, 574, 575, 586, 587, 606, 607, 618, 619, 626, 627, 654, 655, 666, 667, 678, 679, 694, 695, 698, 699, 722, 723, 730, 731, 742, 743, 778, 779, 802, 803, 822, 823, 830, 831, 842, 843, 846, 847, 858, 859, 862, 863, 866, 867, 870, 871, 874, 875, 878, 879, 886, 887, 906, 907, 914, 915, 946, 947, 954, 955, 970, 971, 978, 979, 1006, 1007, 1018, 1019, 1022, 1023, 1026, 1027, 1034, 1035, 1038, 1039, 1042, 1043, 1058, 1059, 1082, 1083, 1086, 1087, 1102, 1103, 1118, 1119, 1126, 1127, 1142, 1143, 1146, 1147, 1150, 1151, 1154, 1155, 1158, 1159, 1182, 1183, 1186, 1187, 1190, 1191, 1210, 1211, 1214, 1215, 1254, 1255, 1270, 1271, 1274, 1275, 1278, 1279, 1282, 1283, 1294, 1295, 1298, 1299, 1302, 1303, 1310, 1311, 1330, 1331, 1334, 1335, 1346, 1347, 1354, 1355, 1358, 1359, 1362, 1363, 1366, 1367, 1602, 1603, 1614, 1615, 1618, 1619, 1626, 1627, 1630 or 1631. The nucleobase sequence of the antisense strand may comprise or consist of a nucleobase sequence that is at least 90% identical to any of SEQ ID NOs: 34, 54, 58, 142, 158, 250, 262, 282, 286, 390, 398, 426, 470, 478, 494, 502, 522, 566, 574, 586, 606, 618, 626, 654, 666, 678, 694, 698, 722, 730, 742, 778, 802, 822, 830, 842, 846, 858, 862, 866, 870, 874, 878, 886, 906, 914, 946, 954, 970, 978, 1006, 1018, 1022, 1026, 1034, 1038, 1042, 1058, 1082, 1086, 1102, 1118, 1126, 1142, 1146, 1150, 1154, 1158, 1182, 1186, 1190, 1210, 1214, 1254, 1270, 1274, 1278, 1282, 1294, 1298, 1302, 1310, 1330, 1334, 1346, 1354, 1358, 1362, 1366, 1602, 1614, 1618, 1626 or 1630. The nucleobase sequence of the antisense strand may comprise or consist of a nucleobase sequence that is at least 90% identical to any of SEQ ID NOs: 35, 55, 59, 143, 159, 251, 263, 283, 287, 391, 399, 427, 471, 479, 495, 503, 523, 567, 575, 587, 607, 619, 627, 655, 667, 679, 695, 699, 723, 731, 743, 779, 803, 823, 831, 843, 847, 859, 863, 867, 871, 875, 879, 887, 907, 915, 947, 955, 971, 979, 1007, 1019, 1023, 1027, 1035, 1039, 1043, 1059, 1083, 1087, 1103, 1119, 1127, 1143, 1147, 1151, 1155, 1159, 1183, 1187, 1191, 1211, 1215, 1255, 1271, 1275, 1279, 1283, 1295, 1299, 1303, 1311, 1331, 1335, 1347, 1355, 1359, 1363, 1367, 1603, 1615, 1619, 1627 or 1631. The nucleobase sequence of the antisense strand may comprise or consist of a nucleobase sequence that is at least 95% identical to any of SEQ ID NOs: 2, 3, 6, 7, 10, 11, 14, 15, 18, 19, 22, 23, 26, 27, 30, 31, 34, 35, 38, 39, 42, 43, 46, 47, 50, 51, 54, 55, 58, 59, 62, 63, 66, 67, 70, 71, 74, 75, 78, 79, 82, 83, 86, 87, 90, 91, 94, 95, 98, 99, 102, 103, 106, 107, 110, 111, 114, 115, 118, 119, 122, 123, 126, 127, 130, 131, 134, 135, 138, 139, 142, 143, 146, 147, 150, 151, 154, 155, 158, 159, 162, 163, 166, 167, 170, 171, 174, 175, 178, 179, 182, 183, 186, 187, 190, 191, 194, 195, 198, 199, 202, 203, 206, 207, 210, 211, 214, 215, 218, 219, 222, 223, 226, 227, 230, 231, 234, 235, 238, 239, 242, 243, 246, 247, 250, 251, 254, 255, 258, 259, 262, 263, 266, 267, 270, 271, 274, 275, 278, 279, 282, 283, 286, 287, 290, 291, 294, 295, 298, 299, 302, 303, 306, 307, 310, 311, 314, 315, 318, 319, 322, 323, 326, 327, 330, 331, 334, 335, 338, 339, 342, 343, 346, 347, 350, 351, 354, 355, 358, 359, 362, 363, 366, 367, 370, 371, 374, 375, 378, 379, 382, 383, 386, 387, 390, 391, 394, 395, 398, 399, 402, 403, 406, 407, 410, 411, 414, 415, 418, 419, 422, 423, 426, 427, 430, 431, 434, 435, 438, 439, 442, 443, 446, 447, 450, 451, 454, 455, 458, 459, 462, 463, 466, 467, 470, 471, 474, 475, 478, 479, 482, 483, 486, 487, 490, 491, 494, 495, 498, 499, 502, 503, 506, 507, 510, 511, 514, 515, 518, 519, 522, 523, 526, 527, 530, 531, 534, 535, 538, 539, 542, 543, 546, 547, 550, 551, 554, 555, 558, 559, 562, 563, 566, 567, 570, 571, 574, 575, 578, 579, 582, 583, 586, 587, 590, 591, 594, 595, 598, 599, 602, 603, 606, 607, 610, 611, 614, 615, 618, 619, 622, 623, 626, 627, 630, 631, 634, 635, 638, 639, 642, 643, 646, 647, 650, 651, 654, 655, 658, 659, 662, 663, 666, 667, 670, 671, 674, 675, 678, 679, 682, 683, 686, 687, 690, 691, 694, 695, 698, 699, 702, 703, 706, 707, 710, 711, 714, 715, 718, 719, 722, 723, 726, 727, 730, 731, 734, 735, 738, 739, 742, 743, 746, 747, 750, 751, 754, 755, 758, 759, 762, 763, 766, 767, 770, 771, 774, 775, 778, 779, 782, 783, 786, 787, 790, 791, 794, 795, 798, 799, 802, 803, 806, 807, 810, 811, 814, 815, 818, 819, 822, 823, 826, 827, 830, 831, 834, 835, 838, 839, 842, 843, 846, 847, 850, 851, 854, 855, 858, 859, 862, 863, 866, 867, 870, 871, 874, 875, 878, 879, 882, 883, 886, 887, 890, 891, 894, 895, 898, 899, 902, 903, 906, 907, 910, 911, 914, 915, 918, 919, 922, 923, 926, 927, 930, 931, 934, 935, 938, 939, 942, 943, 946, 947, 950, 951, 954, 955, 958, 959, 962, 963, 966, 967, 970, 971, 974, 975, 978, 979, 982, 983, 986, 987, 990, 991, 994, 995, 998, 999, 1002, 1003, 1006, 1007, 1010, 1011, 1014, 1015, 1018, 1019, 1022, 1023, 1026, 1027, 1030, 1031, 1034, 1035, 1038, 1039, 1042, 1043, 1046, 1047, 1050, 1051, 1054, 1055, 1058, 1059, 1062, 1063, 1066, 1067, 1070, 1071, 1074, 1075, 1078, 1079, 1082, 1083, 1086, 1087, 1090, 1091, 1094, 1095, 1098, 1099, 1102, 1103, 1106, 1107, 1110, 1111, 1114, 1115, 1118, 1119, 1122, 1123, 1126, 1127, 1130, 1131, 1134, 1135, 1138, 1139, 1142, 1143, 1146, 1147, 1150, 1151, 1154, 1155, 1158, 1159, 1162, 1163, 1166, 1167, 1170, 1171, 1174, 1175, 1178, 1179, 1182, 1183, 1186, 1187, 1190, 1191, 1194, 1195, 1198, 1199, 1202, 1203, 1206, 1207, 1210, 1211, 1214, 1215, 1218, 1219, 1222, 1223, 1226, 1227, 1230, 1231, 1234, 1235, 1238, 1239, 1242, 1243, 1246, 1247, 1250, 1251, 1254, 1255, 1258, 1259, 1262, 1263, 1266, 1267, 1270, 1271, 1274, 1275, 1278, 1279, 1282, 1283, 1286, 1287, 1290, 1291, 1294, 1295, 1298, 1299, 1302, 1303, 1306, 1307, 1310, 1311, 1314, 1315, 1318, 1319, 1322, 1323, 1326, 1327, 1330, 1331, 1334, 1335, 1338, 1339, 1342, 1343, 1346, 1347, 1350, 1351, 1354, 1355, 1358, 1359, 1362, 1363, 1366, 1367, 1370, 1371, 1374, 1375, 1378, 1379, 1382, 1383, 1386, 1387, 1390, 1391, 1394, 1395, 1398, 1399, 1402, 1403, 1406, 1407, 1410, 1411, 1414, 1415, 1418, 1419, 1422, 1423, 1426, 1427, 1430, 1431, 1434, 1435, 1438, 1439, 1442, 1443, 1446, 1447, 1450, 1451, 1454, 1455, 1458, 1459, 1462, 1463, 1466, 1467, 1470, 1471, 1474, 1475, 1478, 1479, 1482, 1483, 1486, 1487, 1490, 1491, 1494, 1495, 1498, 1499, 1502, 1503, 1506, 1507, 1510, 1511, 1514, 1515, 1518, 1519, 1522, 1523, 1526, 1527, 1530, 1531, 1534, 1535, 1538, 1539, 1542, 1543, 1546, 1547, 1550, 1551, 1554, 1555, 1558, 1559, 1562, 1563, 1566, 1567, 1570, 1571, 1574, 1575, 1578, 1579, 1582, 1583, 1586, 1587, 1590, 1591, 1594, 1595, 1598, 1599, 1602, 1603, 1606, 1607, 1610, 1611, 1614, 1615, 1618, 1619, 1622, 1623, 1626, 1627, 1630, 1631, 1634, 1635, 1638, 1639, 1642, 1643, 1646, 1647, 1650, 1651, 1654, 1655, 1658, 1659, 1662, 1663, 1666, 1667, 1670, 1671, 1674, 1675, 1678, 1679, 1682, 1683, 1686, 1687, 1690, 1691, 1694, 1695, 1698, 1699, 1702, 1703, 1706, 1707, 1710, 1711, 1714, 1715, 1718, 1719, 1722, 1723, 1726, 1727, 1730, 1731, 1734, 1735, 1738, 1739, 1742, 1743, 1746, 1747, 1750, 1751, 1754, 1755, 1758, 1759, 1762, 1763, 1766, 1767, 1770, 1771, 1774, 1775, 1778, 1779, 1782, 1783, 1786, 1787, 1790, 1791, 1794, 1795, 1798, 1799, 1802, 1803, 1806, 1807, 1810, 1811, 1814, 1815, 1818, 1819, 1822, 1823, 1826, 1827, 1830, 1831, 1834, 1835, 1838, 1839, 1842, 1843, 1846, 1847, 1850, 1851, 1854, 1855, 1858, 1859, 1862, 1863, 1866, 1867, 1870, 1871, 1874, 1875, 1878, 1879, 1882, 1883, 1886, 1887, 1890, 1891, 1894, 1895, 1898, 1899, 1902, 1903, 1906, 1907, 1910, 1911, 1914, 1915, 1918 or 1919. The nucleobase sequence of the antisense strand may comprise or consist of a nucleobase sequence that is at least 95% identical to any of SEQ ID NOs: 2, 6, 10, 14, 18, 22, 26, 30, 34, 38, 42, 46, 50, 54, 58, 62, 66, 70, 74, 78, 82, 86, 90, 94, 98, 102, 106, 110, 114, 118, 122, 126, 130, 134, 138, 142, 146, 150, 154, 158, 162, 166, 170, 174, 178, 182, 186, 190, 194, 198, 202, 206, 210, 214, 218, 222, 226, 230, 234, 238, 242, 246, 250, 254, 258, 262, 266, 270, 274, 278, 282, 286, 290, 294, 298, 302, 306, 310, 314, 318, 322, 326, 330, 334, 338, 342, 346, 350, 354, 358, 362, 366, 370, 374, 378, 382, 386, 390, 394, 398, 402, 406, 410, 414, 418, 422, 426, 430, 434, 438, 442, 446, 450, 454, 458, 462, 466, 470, 474, 478, 482, 486, 490, 494, 498, 502, 506, 510, 514, 518, 522, 526, 530, 534, 538, 542, 546, 550, 554, 558, 562, 566, 570, 574, 578, 582, 586, 590, 594, 598, 602, 606, 610, 614, 618, 622, 626, 630, 634, 638, 642, 646, 650, 654, 658, 662, 666, 670, 674, 678, 682, 686, 690, 694, 698, 702, 706, 710, 714, 718, 722, 726, 730, 734, 738, 742, 746, 750, 754, 758, 762, 766, 770, 774, 778, 782, 786, 790, 794, 798, 802, 806, 810, 814, 818, 822, 826, 830, 834, 838, 842, 846, 850, 854, 858, 862, 866, 870, 874, 878, 882, 886, 890, 894, 898, 902, 906, 910, 914, 918, 922, 926, 930, 934, 938, 942, 946, 950, 954, 958, 962, 966, 970, 974, 978, 982, 986, 990, 994, 998, 1002, 1006, 1010, 1014, 1018, 1022, 1026, 1030, 1034, 1038, 1042, 1046, 1050, 1054, 1058, 1062, 1066, 1070, 1074, 1078, 1082, 1086, 1090, 1094, 1098, 1102, 1106, 1110, 1114, 1118, 1122, 1126, 1130, 1134, 1138, 1142, 1146, 1150, 1154, 1158, 1162, 1166, 1170, 1174, 1178, 1182, 1186, 1190, 1194, 1198, 1202, 1206, 1210, 1214, 1218, 1222, 1226, 1230, 1234, 1238, 1242, 1246, 1250, 1254, 1258, 1262, 1266, 1270, 1274, 1278, 1282, 1286, 1290, 1294, 1298, 1302, 1306, 1310, 1314, 1318, 1322, 1326, 1330, 1334, 1338, 1342, 1346, 1350, 1354, 1358, 1362, 1366, 1370, 1374, 1378, 1382, 1386, 1390, 1394, 1398, 1402, 1406, 1410, 1414, 1418, 1422, 1426, 1430, 1434, 1438, 1442, 1446, 1450, 1454, 1458, 1462, 1466, 1470, 1474, 1478, 1482, 1486, 1490, 1494, 1498, 1502, 1506, 1510, 1514, 1518, 1522, 1526, 1530, 1534, 1538, 1542, 1546, 1550, 1554, 1558, 1562, 1566, 1570, 1574, 1578, 1582, 1586, 1590, 1594, 1598, 1602, 1606, 1610, 1614, 1618, 1622, 1626, 1630, 1634, 1638, 1642, 1646, 1650, 1654, 1658, 1662, 1666, 1670, 1674, 1678, 1682, 1686, 1690, 1694, 1698, 1702, 1706, 1710, 1714, 1718, 1722, 1726, 1730, 1734, 1738, 1742, 1746, 1750, 1754, 1758, 1762, 1766, 1770, 1774, 1778, 1782, 1786, 1790, 1794, 1798, 1802, 1806, 1810, 1814, 1818, 1822, 1826, 1830, 1834, 1838, 1842, 1846, 1850, 1854, 1858, 1862, 1866, 1870, 1874, 1878, 1882, 1886, 1890, 1894, 1898, 1902, 1906, 1910, 1914 or 1918. The nucleobase sequence of the antisense strand may comprise or consist of a nucleobase sequence that is at least 95% identical to any of SEQ ID NOs: 3, 7, 11, 15, 19, 23, 27, 31, 35, 39, 43, 47, 51, 55, 59, 63, 67, 71, 75, 79, 83, 87, 91, 95, 99, 103, 107, 111, 115, 119, 123, 127, 131, 135, 139, 143, 147, 151, 155, 159, 163, 167, 171, 175, 179, 183, 187, 191, 195, 199, 203, 207, 211, 215, 219, 223, 227, 231, 235, 239, 243, 247, 251, 255, 259, 263, 267, 271, 275, 279, 283, 287, 291, 295, 299, 303, 307, 311, 315, 319, 323, 327, 331, 335, 339, 343, 347, 351, 355, 359, 363, 367, 371, 375, 379, 383, 387, 391, 395, 399, 403, 407, 411, 415, 419, 423, 427, 431, 435, 439, 443, 447, 451, 455, 459, 463, 467, 471, 475, 479, 483, 487, 491, 495, 499, 503, 507, 511, 515, 519, 523, 527, 531, 535, 539, 543, 547, 551, 555, 559, 563, 567, 571, 575, 579, 583, 587, 591, 595, 599, 603, 607, 611, 615, 619, 623, 627, 631, 635, 639, 643, 647, 651, 655, 659, 663, 667, 671, 675, 679, 683, 687, 691, 695, 699, 703, 707, 711, 715, 719, 723, 727, 731, 735, 739, 743, 747, 751, 755, 759, 763, 767, 771, 775, 779, 783, 787, 791, 795, 799, 803, 807, 811, 815, 819, 823, 827, 831, 835, 839, 843, 847, 851, 855, 859, 863, 867, 871, 875, 879, 883, 887, 891, 895, 899, 903, 907, 911, 915, 919, 923, 927, 931, 935, 939, 943, 947, 951, 955, 959, 963, 967, 971, 975, 979, 983, 987, 991, 995, 999, 1003, 1007, 1011, 1015, 1019, 1023, 1027, 1031, 1035, 1039, 1043, 1047, 1051, 1055, 1059, 1063, 1067, 1071, 1075, 1079, 1083, 1087, 1091, 1095, 1099, 1103, 1107, 1111, 1115, 1119, 1123, 1127, 1131, 1135, 1139, 1143, 1147, 1151, 1155, 1159, 1163, 1167, 1171, 1175, 1179, 1183, 1187, 1191, 1195, 1199, 1203, 1207, 1211, 1215, 1219, 1223, 1227, 1231, 1235, 1239, 1243, 1247, 1251, 1255, 1259, 1263, 1267, 1271, 1275, 1279, 1283, 1287, 1291, 1295, 1299, 1303, 1307, 1311, 1315, 1319, 1323, 1327, 1331, 1335, 1339, 1343, 1347, 1351, 1355, 1359, 1363, 1367, 1371, 1375, 1379, 1383, 1387, 1391, 1395, 1399, 1403, 1407, 1411, 1415, 1419, 1423, 1427, 1431, 1435, 1439, 1443, 1447, 1451, 1455, 1459, 1463, 1467, 1471, 1475, 1479, 1483, 1487, 1491, 1495, 1499, 1503, 1507, 1511, 1515, 1519, 1523, 1527, 1531, 1535, 1539, 1543, 1547, 1551, 1555, 1559, 1563, 1567, 1571, 1575, 1579, 1583, 1587, 1591, 1595, 1599, 1603, 1607, 1611, 1615, 1619, 1623, 1627, 1631, 1635, 1639, 1643, 1647, 1651, 1655, 1659, 1663, 1667, 1671, 1675, 1679, 1683, 1687, 1691, 1695, 1699, 1703, 1707, 1711, 1715, 1719, 1723, 1727, 1731, 1735, 1739, 1743, 1747, 1751, 1755, 1759, 1763, 1767, 1771, 1775, 1779, 1783, 1787, 1791, 1795, 1799, 1803, 1807, 1811, 1815, 1819, 1823, 1827, 1831, 1835, 1839, 1843, 1847, 1851, 1855, 1859, 1863, 1867, 1871, 1875, 1879, 1883, 1887, 1891, 1895, 1899, 1903, 1907, 1911, 1915 or 1919. The nucleobase sequence of the antisense strand may comprise or consist of a nucleobase sequence that is at least 95% identical to any of SEQ ID NOs: 34, 35, 54, 55, 58, 59, 142, 143, 158, 159, 250, 251, 262, 263, 282, 283, 286, 287, 390, 391, 398, 399, 426, 427, 470, 471, 478, 479, 494, 495, 502, 503, 522, 523, 566, 567, 574, 575, 586, 587, 606, 607, 618, 619, 626, 627, 654, 655, 666, 667, 678, 679, 694, 695, 698, 699, 722, 723, 730, 731, 742, 743, 778, 779, 802, 803, 822, 823, 830, 831, 842, 843, 846, 847, 858, 859, 862, 863, 866, 867, 870, 871, 874, 875, 878, 879, 886, 887, 906, 907, 914, 915, 946, 947, 954, 955, 970, 971, 978, 979, 1006, 1007, 1018, 1019, 1022, 1023, 1026, 1027, 1034, 1035, 1038, 1039, 1042, 1043, 1058, 1059, 1082, 1083, 1086, 1087, 1102, 1103, 1118, 1119, 1126, 1127, 1142, 1143, 1146, 1147, 1150, 1151, 1154, 1155, 1158, 1159, 1182, 1183, 1186, 1187, 1190, 1191, 1210, 1211, 1214, 1215, 1254, 1255, 1270, 1271, 1274, 1275, 1278, 1279, 1282, 1283, 1294, 1295, 1298, 1299, 1302, 1303, 1310, 1311, 1330, 1331, 1334, 1335, 1346, 1347, 1354, 1355, 1358, 1359, 1362, 1363, 1366, 1367, 1602, 1603, 1614, 1615, 1618, 1619, 1626, 1627, 1630 or 1631. The nucleobase sequence of the antisense strand may comprise or consist of a nucleobase sequence that is at least 95% identical to any of SEQ ID NOs: 34, 54, 58, 142, 158, 250, 262, 282, 286, 390, 398, 426, 470, 478, 494, 502, 522, 566, 574, 586, 606, 618, 626, 654, 666, 678, 694, 698, 722, 730, 742, 778, 802, 822, 830, 842, 846, 858, 862, 866, 870, 874, 878, 886, 906, 914, 946, 954, 970, 978, 1006, 1018, 1022, 1026, 1034, 1038, 1042, 1058, 1082, 1086, 1102, 1118, 1126, 1142, 1146, 1150, 1154, 1158, 1182, 1186, 1190, 1210, 1214, 1254, 1270, 1274, 1278, 1282, 1294, 1298, 1302, 1310, 1330, 1334, 1346, 1354, 1358, 1362, 1366, 1602, 1614, 1618, 1626 or 1630. The nucleobase sequence of the antisense strand may comprise or consist of a nucleobase sequence that is at least 95% identical to any of SEQ ID NOs: 35, 55, 59, 143, 159, 251, 263, 283, 287, 391, 399, 427, 471, 479, 495, 503, 523, 567, 575, 587, 607, 619, 627, 655, 667, 679, 695, 699, 723, 731, 743, 779, 803, 823, 831, 843, 847, 859, 863, 867, 871, 875, 879, 887, 907, 915, 947, 955, 971, 979, 1007, 1019, 1023, 1027, 1035, 1039, 1043, 1059, 1083, 1087, 1103, 1119, 1127, 1143, 1147, 1151, 1155, 1159, 1183, 1187, 1191, 1211, 1215, 1255, 1271, 1275, 1279, 1283, 1295, 1299, 1303, 1311, 1331, 1335, 1347, 1355, 1359, 1363, 1367, 1603, 1615, 1619, 1627 or 1631. The nucleobase sequence of the antisense strand may comprise or consist of a nucleobase sequence that is at least 99% identical to any of SEQ ID NOs: 2, 3, 6, 7, 10, 11, 14, 15, 18, 19, 22, 23, 26, 27, 30, 31, 34, 35, 38, 39, 42, 43, 46, 47, 50, 51, 54, 55, 58, 59, 62, 63, 66, 67, 70, 71, 74, 75, 78, 79, 82, 83, 86, 87, 90, 91, 94, 95, 98, 99, 102, 103, 106, 107, 110, 111, 114, 115, 118, 119, 122, 123, 126, 127, 130, 131, 134, 135, 138, 139, 142, 143, 146, 147, 150, 151, 154, 155, 158, 159, 162, 163, 166, 167, 170, 171, 174, 175, 178, 179, 182, 183, 186, 187, 190, 191, 194, 195, 198, 199, 202, 203, 206, 207, 210, 211, 214, 215, 218, 219, 222, 223, 226, 227, 230, 231, 234, 235, 238, 239, 242, 243, 246, 247, 250, 251, 254, 255, 258, 259, 262, 263, 266, 267, 270, 271, 274, 275, 278, 279, 282, 283, 286, 287, 290, 291, 294, 295, 298, 299, 302, 303, 306, 307, 310, 311, 314, 315, 318, 319, 322, 323, 326, 327, 330, 331, 334, 335, 338, 339, 342, 343, 346, 347, 350, 351, 354, 355, 358, 359, 362, 363, 366, 367, 370, 371, 374, 375, 378, 379, 382, 383, 386, 387, 390, 391, 394, 395, 398, 399, 402, 403, 406, 407, 410, 411, 414, 415, 418, 419, 422, 423, 426, 427, 430, 431, 434, 435, 438, 439, 442, 443, 446, 447, 450, 451, 454, 455, 458, 459, 462, 463, 466, 467, 470, 471, 474, 475, 478, 479, 482, 483, 486, 487, 490, 491, 494, 495, 498, 499, 502, 503, 506, 507, 510, 511, 514, 515, 518, 519, 522, 523, 526, 527, 530, 531, 534, 535, 538, 539, 542, 543, 546, 547, 550, 551, 554, 555, 558, 559, 562, 563, 566, 567, 570, 571, 574, 575, 578, 579, 582, 583, 586, 587, 590, 591, 594, 595, 598, 599, 602, 603, 606, 607, 610, 611, 614, 615, 618, 619, 622, 623, 626, 627, 630, 631, 634, 635, 638, 639, 642, 643, 646, 647, 650, 651, 654, 655, 658, 659, 662, 663, 666, 667, 670, 671, 674, 675, 678, 679, 682, 683, 686, 687, 690, 691, 694, 695, 698, 699, 702, 703, 706, 707, 710, 711, 714, 715, 718, 719, 722, 723, 726, 727, 730, 731, 734, 735, 738, 739, 742, 743, 746, 747, 750, 751, 754, 755, 758, 759, 762, 763, 766, 767, 770, 771, 774, 775, 778, 779, 782, 783, 786, 787, 790, 791, 794, 795, 798, 799, 802, 803, 806, 807, 810, 811, 814, 815, 818, 819, 822, 823, 826, 827, 830, 831, 834, 835, 838, 839, 842, 843, 846, 847, 850, 851, 854, 855, 858, 859, 862, 863, 866, 867, 870, 871, 874, 875, 878, 879, 882, 883, 886, 887, 890, 891, 894, 895, 898, 899, 902, 903, 906, 907, 910, 911, 914, 915, 918, 919, 922, 923, 926, 927, 930, 931, 934, 935, 938, 939, 942, 943, 946, 947, 950, 951, 954, 955, 958, 959, 962, 963, 966, 967, 970, 971, 974, 975, 978, 979, 982, 983, 986, 987, 990, 991, 994, 995, 998, 999, 1002, 1003, 1006, 1007, 1010, 1011, 1014, 1015, 1018, 1019, 1022, 1023, 1026, 1027, 1030, 1031, 1034, 1035, 1038, 1039, 1042, 1043, 1046, 1047, 1050, 1051, 1054, 1055, 1058, 1059, 1062, 1063, 1066, 1067, 1070, 1071, 1074, 1075, 1078, 1079, 1082, 1083, 1086, 1087, 1090, 1091, 1094, 1095, 1098, 1099, 1102, 1103, 1106, 1107, 1110, 1111, 1114, 1115, 1118, 1119, 1122, 1123, 1126, 1127, 1130, 1131, 1134, 1135, 1138, 1139, 1142, 1143, 1146, 1147, 1150, 1151, 1154, 1155, 1158, 1159, 1162, 1163, 1166, 1187, 1190, 1191, 1194, 1195, 1198, 1199, 1202, 1203, 1206, 1207, 1210, 1211, 1214, 1215, 1218, 1219, 1222, 1223, 1226, 1227, 1230, 1231, 1234, 1235, 1238, 1239, 1242, 1243, 1246, 1247, 1250, 1251, 1254, 1255, 1258, 1259, 1262, 1263, 1266, 1267, 1270, 1271, 1274, 1275, 1278, 1279, 1282, 1283, 1286, 1287, 1290, 1291, 1294, 1295, 1298, 1299, 1302, 1303, 1306, 1307, 1310, 1311, 1314, 1315, 1318, 1319, 1322, 1323, 1326, 1327, 1330, 1331, 1334, 1335, 1338, 1339, 1342, 1343, 1346, 1347, 1350, 1351, 1354, 1355, 1358, 1359, 1362, 1363, 1366, 1367, 1370, 1371, 1374, 1375, 1378, 1379, 1382, 1383, 1386, 1387, 1390, 1391, 1394, 1395, 1398, 1399, 1402, 1403, 1406, 1407, 1410, 1411, 1414, 1415, 1418, 1419, 1422, 1423, 1426, 1427, 1430, 1431, 1434, 1435, 1438, 1439, 1442, 1443, 1446, 1447, 1450, 1451, 1454, 1455, 1458, 1459, 1462, 1463, 1466, 1467, 1470, 1471, 1474, 1475, 1478, 1479, 1482, 1483, 1486, 1487, 1490, 1491, 1494, 1495, 1498, 1499, 1502, 1503, 1506, 1507, 1510, 1511, 1514, 1515, 1518, 1519, 1522, 1523, 1526, 1527, 1530, 1531, 1534, 1535, 1538, 1539, 1542, 1543, 1546, 1547, 1550, 1551, 1554, 1555, 1558, 1559, 1562, 1563, 1566, 1567, 1570, 1571, 1574, 1575, 1578, 1579, 1582, 1583, 1586, 1587, 1590, 1591, 1594, 1595, 1598, 1599, 1602, 1603, 1606, 1607, 1610, 1611, 1614, 1615, 1618, 1619, 1622, 1623, 1626, 1627, 1630, 1631, 1634, 1635, 1638, 1639, 1642, 1643, 1646, 1647, 1650, 1651, 1654, 1655, 1658, 1659, 1662, 1663, 1666, 1667, 1670, 1671, 1674, 1675, 1678, 1679, 1682, 1683, 1686, 1687, 1690, 1691, 1694, 1695, 1698, 1699, 1702, 1703, 1706, 1707, 1710, 1711, 1714, 1715, 1718, 1719, 1722, 1723, 1726, 1727, 1730, 1731, 1734, 1735, 1738, 1739, 1742, 1743, 1746, 1747, 1750, 1751, 1754, 1755, 1758, 1759, 1762, 1763, 1766, 1767, 1770, 1771, 1774, 1775, 1778, 1779, 1782, 1783, 1786, 1787, 1790, 1791, 1794, 1795, 1798, 1799, 1802, 1803, 1806, 1807, 1810, 1811, 1814, 1815, 1818, 1819, 1822, 1823, 1826, 1827, 1830, 1831, 1834, 1835, 1838, 1839, 1842, 1843, 1846, 1847, 1850, 1851, 1854, 1855, 1858, 1859, 1862, 1863, 1866, 1867, 1870, 1871, 1874, 1875, 1878, 1879, 1882, 1883, 1886, 1887, 1890, 1891, 1894, 1895, 1898, 1899, 1902, 1903, 1906, 1907, 1910, 1911, 1914, 1915, 1918 or 1919. The nucleobase sequence of the antisense strand may comprise or consist of a nucleobase sequence that is at least 99% identical to any of SEQ ID NOs: 2, 6, 10, 14, 18, 22, 26, 30, 34, 38, 42, 46, 50, 54, 58, 62, 66, 70, 74, 78, 82, 86, 90, 94, 98, 102, 106, 110, 114, 118, 122, 126, 130, 134, 138, 142, 146, 150, 154, 158, 162, 166, 170, 174, 178, 182, 186, 190, 194, 198, 202, 206, 210, 214, 218, 222, 226, 230, 234, 238, 242, 246, 250, 254, 258, 262, 266, 270, 274, 278, 282, 286, 290, 294, 298, 302, 306, 310, 314, 318, 322, 326, 330, 334, 338, 342, 346, 350, 354, 358, 362, 366, 370, 374, 378, 382, 386, 390, 394, 398, 402, 406, 410, 414, 418, 422, 426, 430, 434, 438, 442, 446, 450, 454, 458, 462, 466, 470, 474, 478, 482, 486, 490, 494, 498, 502, 506, 510, 514, 518, 522, 526, 530, 534, 538, 542, 546, 550, 554, 558, 562, 566, 570, 574, 578, 582, 586, 590, 594, 598, 602, 606, 610, 614, 618, 622, 626, 630, 634, 638, 642, 646, 650, 654, 658, 662, 666, 670, 674, 678, 682, 686, 690, 694, 698, 702, 706, 710, 714, 718, 722, 726, 730, 734, 738, 742, 746, 750, 754, 758, 762, 766, 770, 774, 778, 782, 786, 790, 794, 798, 802, 806, 810, 814, 818, 822, 826, 830, 834, 838, 842, 846, 850, 854, 858, 862, 866, 870, 874, 878, 882, 886, 890, 894, 898, 902, 906, 910, 914, 918, 922, 926, 930, 934, 938, 942, 946, 950, 954, 958, 962, 966, 970, 974, 978, 982, 986, 990, 994, 998, 1002, 1006, 1010, 1014, 1018, 1022, 1026, 1030, 1034, 1038, 1042, 1046, 1050, 1054, 1058, 1062, 1066, 1070, 1074, 1078, 1082, 1086, 1090, 1094, 1098, 1102, 1106, 1110, 1114, 1118, 1122, 1126, 1130, 1134, 1138, 1142, 1146, 1150, 1154, 1158, 1162, 1166, 1170, 1174, 1178, 1182, 1186, 1190, 1194, 1198, 1202, 1206, 1210, 1214, 1218, 1222, 1226, 1230, 1234, 1238, 1242, 1246, 1250, 1254, 1258, 1262, 1266, 1270, 1274, 1278, 1282, 1286, 1290, 1294, 1298, 1302, 1306, 1310, 1314, 1318, 1322, 1326, 1330, 1334, 1338, 1342, 1346, 1350, 1354, 1358, 1362, 1366, 1370, 1374, 1378, 1382, 1386, 1390, 1394, 1398, 1402, 1406, 1410, 1414, 1418, 1422, 1426, 1430, 1434, 1438, 1442, 1446, 1450, 1454, 1458, 1462, 1466, 1470, 1474, 1478, 1482, 1486, 1490, 1494, 1498, 1502, 1506, 1510, 1514, 1518, 1522, 1526, 1530, 1534, 1538, 1542, 1546, 1550, 1554, 1558, 1562, 1566, 1570, 1574, 1578, 1582, 1586, 1590, 1594, 1598, 1602, 1606, 1610, 1614, 1618, 1622, 1626, 1630, 1634, 1638, 1642, 1646, 1650, 1654, 1658, 1662, 1666, 1670, 1674, 1678, 1682, 1686, 1690, 1694, 1698, 1702, 1706, 1710, 1714, 1718, 1722, 1726, 1730, 1734, 1738, 1742, 1746, 1750, 1754, 1758, 1762, 1766, 1770, 1774, 1778, 1782, 1786, 1790, 1794, 1798, 1802, 1806, 1810, 1814, 1818, 1822, 1826, 1830, 1834, 1838, 1842, 1846, 1850, 1854, 1858, 1862, 1866, 1870, 1874, 1878, 1882, 1886, 1890, 1894, 1898, 1902, 1906, 1910, 1914 or 1918. The nucleobase sequence of the antisense strand may comprise or consist of a nucleobase sequence that is at least 99% identical to any of SEQ ID NOs: 3, 7, 11, 15, 19, 23, 27, 31, 35, 39, 43, 47, 51, 55, 59, 63, 67, 71, 75, 79, 83, 87, 91, 95, 99, 103, 107, 111, 115, 119, 123, 127, 131, 135, 139, 143, 147, 151, 155, 159, 163, 167, 171, 175, 179, 183, 187, 191, 195, 199, 203, 207, 211, 215, 219, 223, 227, 231, 235, 239, 243, 247, 251, 255, 259, 263, 267, 271, 275, 279, 283, 287, 291, 295, 299, 303, 307, 311, 315, 319, 323, 327, 331, 335, 339, 343, 347, 351, 355, 359, 363, 367, 371, 375, 379, 383, 387, 391, 395, 399, 403, 407, 411, 415, 419, 423, 427, 431, 435, 439, 443, 447, 451, 455, 459, 463, 467, 471, 475, 479, 483, 487, 491, 495, 499, 503, 507, 511, 515, 519, 523, 527, 531, 535, 539, 543, 547, 551, 555, 559, 563, 567, 571, 575, 579, 583, 587, 591, 595, 599, 603, 607, 611, 615, 619, 623, 627, 631, 635, 639, 643, 647, 651, 655, 659, 663, 667, 671, 675, 679, 683, 687, 691, 695, 699, 703, 707, 711, 715, 719, 723, 727, 731, 735, 739, 743, 747, 751, 755, 759, 763, 767, 771, 775, 779, 783, 787, 791, 795, 799, 803, 807, 811, 815, 819, 823, 827, 831, 835, 839, 843, 847, 851, 855, 859, 863, 867, 871, 875, 879, 883, 887, 891, 895, 899, 903, 907, 911, 915, 919, 923, 927, 931, 935, 939, 943, 947, 951, 955, 959, 963, 967, 971, 975, 979, 983, 987, 991, 995, 999, 1003, 1007, 1011, 1015, 1019, 1023, 1027, 1031, 1035, 1039, 1043, 1047, 1051, 1055, 1059, 1063, 1067, 1071, 1075, 1079, 1083, 1087, 1091, 1095, 1099, 1103, 1107, 1111, 1115, 1119, 1123, 1127, 1131, 1135, 1139, 1143, 1147, 1151, 1155, 1159, 1163, 1167, 1171, 1175, 1179, 1183, 1187, 1191, 1195, 1199, 1203, 1207, 1211, 1215, 1219, 1223, 1227, 1231, 1235, 1239, 1243, 1247, 1251, 1255, 1259, 1263, 1267, 1271, 1275, 1279, 1283, 1287, 1291, 1295, 1299, 1303, 1307, 1311, 1315, 1319, 1323, 1327, 1331, 1335, 1339, 1343, 1347, 1351, 1355, 1359, 1363, 1367, 1371, 1375, 1379, 1383, 1387, 1391, 1395, 1399, 1403, 1407, 1411, 1415, 1419, 1423, 1427, 1431, 1435, 1439, 1443, 1447, 1451, 1455, 1459, 1463, 1467, 1471, 1475, 1479, 1483, 1487, 1491, 1495, 1499, 1503, 1507, 1511, 1515, 1519, 1523, 1527, 1531, 1535, 1539, 1543, 1547, 1551, 1555, 1559, 1563, 1567, 1571, 1575, 1579, 1583, 1587, 1591, 1595, 1599, 1603, 1607, 1611, 1615, 1619, 1623, 1627, 1631, 1635, 1639, 1643, 1647, 1651, 1655, 1659, 1663, 1667, 1671, 1675, 1679, 1683, 1687, 1691, 1695, 1699, 1703, 1707, 1711, 1715, 1719, 1723, 1727, 1731, 1735, 1739, 1743, 1747, 1751, 1755, 1759, 1763, 1767, 1771, 1775, 1779, 1783, 1787, 1791, 1795, 1799, 1803, 1807, 1811, 1815, 1819, 1823, 1827, 1831, 1835, 1839, 1843, 1847, 1851, 1855, 1859, 1863, 1867, 1871, 1875, 1879, 1883, 1887, 1891, 1895, 1899, 1903, 1907, 1911, 1915 or 1919. The nucleobase sequence of the antisense strand may comprise or consist of a nucleobase sequence that is at least 99% identical to any of SEQ ID NOs: 34, 35, 54, 55, 58, 59, 142, 143, 158, 159, 250, 251, 262, 263, 282, 283, 286, 287, 390, 391, 398, 399, 426, 427, 470, 471, 478, 479, 494, 495, 502, 503, 522, 523, 566, 567, 574, 575, 586, 587, 606, 607, 618, 619, 626, 627, 654, 655, 666, 667, 678, 679, 694, 695, 698, 699, 722, 723, 730, 731, 742, 743, 778, 779, 802, 803, 822, 823, 830, 831, 842, 843, 846, 847, 858, 859, 862, 863, 866, 867, 870, 871, 874, 875, 878, 879, 886, 887, 906, 907, 914, 915, 946, 947, 954, 955, 970, 971, 978, 979, 1006, 1007, 1018, 1019, 1022, 1023, 1026, 1027, 1034, 1035, 1038, 1039, 1042, 1043, 1058, 1059, 1082, 1083, 1086, 1087, 1102, 1103, 1118, 1119, 1126, 1127, 1142, 1143, 1146, 1147, 1150, 1151, 1154, 1155, 1158, 1159, 1182, 1183, 1186, 1187, 1190, 1191, 1210, 1211, 1214, 1215, 1254, 1255, 1270, 1271, 1274, 1275, 1278, 1279, 1282, 1283, 1294, 1295, 1298, 1299, 1302, 1303, 1310, 1311, 1330, 1331, 1334, 1335, 1346, 1347, 1354, 1355, 1358, 1359, 1362, 1363, 1366, 1367, 1602, 1603, 1614, 1615, 1618, 1619, 1626, 1627, 1630 or 1631. The nucleobase sequence of the antisense strand may comprise or consist of a nucleobase sequence that is at least 99% identical to any of SEQ ID NOs: 34, 54, 58, 142, 158, 250, 262, 282, 286, 390, 398, 426, 470, 478, 494, 502, 522, 566, 574, 586, 606, 618, 626, 654, 666, 678, 694, 698, 722, 730, 742, 778, 802, 822, 830, 842, 846, 858, 862, 866, 870, 874, 878, 886, 906, 914, 946, 954, 970, 978, 1006, 1018, 1022, 1026, 1034, 1038, 1042, 1058, 1082, 1086, 1102, 1118, 1126, 1142, 1146, 1150, 1154, 1158, 1182, 1186, 1190, 1210, 1214, 1254, 1270, 1274, 1278, 1282, 1294, 1298, 1302, 1310, 1330, 1334, 1346, 1354, 1358, 1362, 1366, 1602, 1614, 1618, 1626 or 1630. The nucleobase sequence of the antisense strand may comprise or consist of a nucleobase sequence that is at least 99% identical to any of SEQ ID NOs: 35, 55, 59, 143, 159, 251, 263, 283, 287, 391, 399, 427, 471, 479, 495, 503, 523, 567, 575, 587, 607, 619, 627, 655, 667, 679, 695, 699, 723, 731, 743, 779, 803, 823, 831, 843, 847, 859, 863, 867, 871, 875, 879, 887, 907, 915, 947, 955, 971, 979, 1007, 1019, 1023, 1027, 1035, 1039, 1043, 1059, 1083, 1087, 1103, 1119, 1127, 1143, 1147, 1151, 1155, 1159, 1183, 1187, 1191, 1211, 1215, 1255, 1271, 1275, 1279, 1283, 1295, 1299, 1303, 1311, 1331, 1335, 1347, 1355, 1359, 1363, 1367, 1603, 1615, 1619, 1627 or 1631. The antisense strand may have a nucleobase sequence comprising at least 15, at least 16, at least 17, at least 18, at least 19, at least 20, at least 21, at least 22, or at least 23 contiguous nucleobases, particularly 19, 20, 21, 22 or 23 contiguous nucleobases of any of SEQ ID NOs: 2, 3, 6, 7, 10, 11, 14, 15, 18, 19, 22, 23, 26, 27, 30, 31, 34, 35, 38, 39, 42, 43, 46, 47, 50, 51, 54, 55, 58, 59, 62, 63, 66, 67, 70, 71, 74, 75, 78, 79, 82, 83, 86, 87, 90, 91, 94, 95, 98, 99, 102, 103, 106, 107, 110, 111, 114, 115, 118, 119, 122, 123, 126, 127, 130, 131, 134, 135, 138, 139, 142, 143, 146, 147, 150, 151, 154, 155, 158, 159, 162, 163, 166, 167, 170, 171, 174, 175, 178, 179, 182, 183, 186, 187, 190, 191, 194, 195, 198, 199, 202, 203, 206, 207, 210, 211, 214, 215, 218, 219, 222, 223, 226, 227, 230, 231, 234, 235, 238, 239, 242, 243, 246, 247, 250, 251, 254, 255, 258, 259, 262, 263, 266, 267, 270, 271, 274, 275, 278, 279, 282, 283, 286, 287, 290, 291, 294, 295, 298, 299, 302, 303, 306, 307, 310, 311, 314, 315, 318, 319, 322, 323, 326, 327, 330, 331, 334, 335, 338, 339, 342, 343, 346, 347, 350, 351, 354, 355, 358, 359, 362, 363, 366, 367, 370, 371, 374, 375, 378, 379, 382, 383, 386, 387, 390, 391, 394, 395, 398, 399, 402, 403, 406, 407, 410, 411, 414, 415, 418, 419, 422, 423, 426, 427, 430, 431, 434, 435, 438, 439, 442, 443, 446, 447, 450, 451, 454, 455, 458, 459, 462, 463, 466, 467, 470, 471, 474, 475, 478, 479, 482, 483, 486, 487, 490, 491, 494, 495, 498, 499, 502, 503, 506, 507, 510, 511, 514, 515, 518, 519, 522, 523, 526, 527, 530, 531, 534, 535, 538, 539, 542, 543, 546, 547, 550, 551, 554, 555, 558, 559, 562, 563, 566, 567, 570, 571, 574, 575, 578, 579, 582, 583, 586, 587, 590, 591, 594, 595, 598, 599, 602, 603, 606, 607, 610, 611, 614, 615, 618, 619, 622, 623, 626, 627, 630, 631, 634, 635, 638, 639, 642, 643, 646, 647, 650, 651, 654, 655, 658, 659, 662, 663, 666, 667, 670, 671, 674, 675, 678, 679, 682, 683, 686, 687, 690, 691, 694, 695, 698, 699, 702, 703, 706, 707, 710, 711, 714, 715, 718, 719, 722, 723, 726, 727, 730, 731, 734, 735, 738, 739, 742, 743, 746, 747, 750, 751, 754, 755, 758, 759, 762, 763, 766, 767, 770, 771, 774, 775, 778, 779, 782, 783, 786, 787, 790, 791, 794, 795, 798, 799, 802, 803, 806, 807, 810, 811, 814, 815, 818, 819, 822, 823, 826, 827, 830, 831, 834, 835, 838, 839, 842, 843, 846, 847, 850, 851, 854, 855, 858, 859, 862, 863, 866, 867, 870, 871, 874, 875, 878, 879, 882, 883, 886, 887, 890, 891, 894, 895, 898, 899, 902, 903, 906, 907, 910, 911, 914, 915, 918, 919, 922, 923, 926, 927, 930, 931, 934, 935, 938, 939, 942, 943, 946, 947, 950, 951, 954, 955, 958, 959, 962, 963, 966, 967, 970, 971, 974, 975, 978, 979, 982, 983, 986, 987, 990, 991, 994, 995, 998, 999, 1002, 1003, 1006, 1007, 1010, 1011, 1014, 1015, 1018, 1019, 1022, 1023, 1026, 1027, 1030, 1031, 1034, 1035, 1038, 1039, 1042, 1043, 1046, 1047, 1050, 1051, 1054, 1055, 1058, 1059, 1062, 1063, 1066, 1067, 1070, 1071, 1074, 1075, 1078, 1079, 1082, 1083, 1086, 1087, 1090, 1091, 1094, 1095, 1098, 1099, 1102, 1103, 1106, 1107, 1110, 1111, 1114, 1115, 1118, 1119, 1122, 1123, 1126, 1127, 1130, 1131, 1134, 1135, 1138, 1139, 1142, 1143, 1146, 1147, 1150, 1151, 1154, 1155, 1158, 1159, 1162, 1163, 1166, 1167, 1170, 1171, 1174, 1175, 1178, 1179, 1182, 1183, 1186, 1187, 1190, 1191, 1194, 1195, 1198, 1199, 1202, 1203, 1206, 1207, 1210, 1211, 1214, 1215, 1218, 1219, 1222, 1223, 1226, 1227, 1230, 1231, 1234, 1235, 1238, 1239, 1242, 1243, 1246, 1247, 1250, 1251, 1254, 1255, 1258, 1259, 1262, 1263, 1266, 1267, 1270, 1271, 1274, 1275, 1278, 1279, 1282, 1283, 1286, 1287, 1290, 1291, 1294, 1295, 1298, 1299, 1302, 1303, 1306, 1307, 1310, 1311, 1314, 1315, 1318, 1319, 1322, 1323, 1326, 1327, 1330, 1331, 1334, 1335, 1338, 1339, 1342, 1343, 1346, 1347, 1350, 1351, 1354, 1355, 1358, 1359, 1362, 1363, 1366, 1367, 1370, 1371, 1374, 1375, 1378, 1379, 1382, 1383, 1386, 1387, 1390, 1391, 1394, 1395, 1398, 1399, 1402, 1403, 1406, 1407, 1410, 1411, 1414, 1415, 1418, 1419, 1422, 1423, 1426, 1427, 1430, 1431, 1434, 1435, 1438, 1439, 1442, 1443, 1446, 1447, 1450, 1451, 1454, 1455, 1458, 1459, 1462, 1463, 1466, 1467, 1470, 1471, 1474, 1475, 1478, 1479, 1482, 1483, 1486, 1487, 1490, 1491, 1494, 1495, 1498, 1499, 1502, 1503, 1506, 1507, 1510, 1511, 1514, 1515, 1518, 1519, 1522, 1523, 1526, 1527, 1530, 1531, 1534, 1535, 1538, 1539, 1542, 1543, 1546, 1547, 1550, 1551, 1554, 1555, 1558, 1559, 1562, 1563, 1566, 1567, 1570, 1571, 1574, 1575, 1578, 1579, 1582, 1583, 1586, 1587, 1590, 1591, 1594, 1595, 1598, 1599, 1602, 1603, 1606, 1607, 1610, 1611, 1614, 1615, 1618, 1619, 1622, 1623, 1626, 1627, 1630, 1631, 1634, 1635, 1638, 1639, 1642, 1643, 1646, 1647, 1650, 1651, 1654, 1655, 1658, 1659, 1662, 1663, 1666, 1667, 1670, 1671, 1674, 1675, 1678, 1679, 1682, 1683, 1686, 1687, 1690, 1691, 1694, 1695, 1698, 1699, 1702, 1703, 1706, 1707, 1710, 1711, 1714, 1715, 1718, 1719, 1722, 1723, 1726, 1727, 1730, 1731, 1734, 1735, 1738, 1739, 1742, 1743, 1746, 1747, 1750, 1751, 1754, 1755, 1758, 1759, 1762, 1763, 1766, 1767, 1770, 1771, 1774, 1775, 1778, 1779, 1782, 1783, 1786, 1787, 1790, 1791, 1794, 1795, 1798, 1799, 1802, 1803, 1806, 1807, 1810, 1811, 1814, 1815, 1818, 1819, 1822, 1823, 1826, 1827, 1830, 1831, 1834, 1835, 1838, 1839, 1842, 1843, 1846, 1847, 1850, 1851, 1854, 1855, 1858, 1859, 1862, 1863, 1866, 1867, 1870, 1871, 1874, 1875, 1878, 1879, 1882, 1883, 1886, 1887, 1890, 1891, 1894, 1895, 1898, 1899, 1902, 1903, 1906, 1907, 1910, 1911, 1914, 1915, 1918 or 1919. The antisense strand may have a nucleobase sequence comprising at least 15, at least 16, at least 17, at least 18, at least 19, at least 20, at least 21, at least 22, or at least 23 contiguous nucleobases, particularly 19, 20, 21, 22 or 23 contiguous nucleobases of any of SEQ ID NOs: 2, 6, 10, 14, 18, 22, 26, 30, 34, 38, 42, 46, 50, 54, 58, 62, 66, 70, 74, 78, 82, 86, 90, 94, 98, 102, 106, 110, 114, 118, 122, 126, 130, 134, 138, 142, 146, 150, 154, 158, 162, 166, 170, 174, 178, 182, 186, 190, 194, 198, 202, 206, 210, 214, 218, 222, 226, 230, 234, 238, 242, 246, 250, 254, 258, 262, 266, 270, 274, 278, 282, 286, 290, 294, 298, 302, 306, 310, 314, 318, 322, 326, 330, 334, 338, 342, 346, 350, 354, 358, 362, 366, 370, 374, 378, 382, 386, 390, 394, 398, 402, 406, 410, 414, 418, 422, 426, 430, 434, 438, 442, 446, 450, 454, 458, 462, 466, 470, 474, 478, 482, 486, 490, 494, 498, 502, 506, 510, 514, 518, 522, 526, 530, 534, 538, 542, 546, 550, 554, 558, 562, 566, 570, 574, 578, 582, 586, 590, 594, 598, 602, 606, 610, 614, 618, 622, 626, 630, 634, 638, 642, 646, 650, 654, 658, 662, 666, 670, 674, 678, 682, 686, 690, 694, 698, 702, 706, 710, 714, 718, 722, 726, 730, 734, 738, 742, 746, 750, 754, 758, 762, 766, 770, 774, 778, 782, 786, 790, 794, 798, 802, 806, 810, 814, 818, 822, 826, 830, 834, 838, 842, 846, 850, 854, 858, 862, 866, 870, 874, 878, 882, 886, 890, 894, 898, 902, 906, 910, 914, 918, 922, 926, 930, 934, 938, 942, 946, 950, 954, 958, 962, 966, 970, 974, 978, 982, 986, 990, 994, 998, 1002, 1006, 1010, 1014, 1018, 1022, 1026, 1030, 1034, 1038, 1042, 1046, 1050, 1054, 1058, 1062, 1066, 1070, 1074, 1078, 1082, 1086, 1090, 1094, 1098, 1102, 1106, 1110, 1114, 1118, 1122, 1126, 1130, 1134, 1138, 1142, 1146, 1150, 1154, 1158, 1162, 1166, 1170, 1174, 1178, 1182, 1186, 1190, 1194, 1198, 1202, 1206, 1210, 1214, 1218, 1222, 1226, 1230, 1234, 1238, 1242, 1246, 1250, 1254, 1258, 1262, 1266, 1270, 1274, 1278, 1282, 1286, 1290, 1294, 1298, 1302, 1306, 1310, 1314, 1318, 1322, 1326, 1330, 1334, 1338, 1342, 1346, 1350, 1354, 1358, 1362, 1366, 1370, 1374, 1378, 1382, 1386, 1390, 1394, 1398, 1402, 1406, 1410, 1414, 1418, 1422, 1426, 1430, 1434, 1438, 1442, 1446, 1450, 1454, 1458, 1462, 1466, 1470, 1474, 1478, 1482, 1486, 1490, 1494, 1498, 1502, 1506, 1510, 1514, 1518, 1522, 1526, 1530, 1534, 1538, 1542, 1546, 1550, 1554, 1558, 1562, 1566, 1570, 1574, 1578, 1582, 1586, 1590, 1594, 1598, 1602, 1606, 1610, 1614, 1618, 1622, 1626, 1630, 1634, 1638, 1642, 1646, 1650, 1654, 1658, 1662, 1666, 1670, 1674, 1678, 1682, 1686, 1690, 1694, 1698, 1702, 1706, 1710, 1714, 1718, 1722, 1726, 1730, 1734, 1738, 1742, 1746, 1750, 1754, 1758, 1762, 1766, 1770, 1774, 1778, 1782, 1786, 1790, 1794, 1798, 1802, 1806, 1810, 1814, 1818, 1822, 1826, 1830, 1834, 1838, 1842, 1846, 1850, 1854, 1858, 1862, 1866, 1870, 1874, 1878, 1882, 1886, 1890, 1894, 1898, 1902, 1906, 1910, 1914 or 1918. The antisense strand may have a nucleobase sequence comprising at least 15, at least 16, at least 17, at least 18, at least 19, at least 20, at least 21, at least 22, or at least 23 contiguous nucleobases, particularly 19, 20, 21, 22 or 23 contiguous nucleobases of any of SEQ ID NOs: 3, 7, 11, 15, 19, 23, 27, 31, 35, 39, 43, 47, 51, 55, 59, 63, 67, 71, 75, 79, 83, 87, 91, 95, 99, 103, 107, 111, 115, 119, 123, 127, 131, 135, 139, 143, 147, 151, 155, 159, 163, 167, 171, 175, 179, 183, 187, 191, 195, 199, 203, 207, 211, 215, 219, 223, 227, 231, 235, 239, 243, 247, 251, 255, 259, 263, 267, 271, 275, 279, 283, 287, 291, 295, 299, 303, 307, 311, 315, 319, 323, 327, 331, 335, 339, 343, 347, 351, 355, 359, 363, 367, 371, 375, 379, 383, 387, 391, 395, 399, 403, 407, 411, 415, 419, 423, 427, 431, 435, 439, 443, 447, 451, 455, 459, 463, 467, 471, 475, 479, 483, 487, 491, 495, 499, 503, 507, 511, 515, 519, 523, 527, 531, 535, 539, 543, 547, 551, 555, 559, 563, 567, 571, 575, 579, 583, 587, 591, 595, 599, 603, 607, 611, 615, 619, 623, 627, 631, 635, 639, 643, 647, 651, 655, 659, 663, 667, 671, 675, 679, 683, 687, 691, 695, 699, 703, 707, 711, 715, 719, 723, 727, 731, 735, 739, 743, 747, 751, 755, 759, 763, 767, 771, 775, 779, 783, 787, 791, 795, 799, 803, 807, 811, 815, 819, 823, 827, 831, 835, 839, 843, 847, 851, 855, 859, 863, 867, 871, 875, 879, 883, 887, 891, 895, 899, 903, 907, 911, 915, 919, 923, 927, 931, 935, 939, 943, 947, 951, 955, 959, 963, 967, 971, 975, 979, 983, 987, 991, 995, 999, 1003, 1007, 1011, 1015, 1019, 1023, 1027, 1031, 1035, 1039, 1043, 1047, 1051, 1055, 1059, 1063, 1067, 1071, 1075, 1079, 1083, 1087, 1091, 1095, 1099, 1103, 1107, 1111, 1115, 1119, 1123, 1127, 1131, 1135, 1139, 1143, 1147, 1151, 1155, 1159, 1163, 1167, 1171, 1175, 1179, 1183, 1187, 1191, 1195, 1199, 1203, 1207, 1211, 1215, 1219, 1223, 1227, 1231, 1235, 1239, 1243, 1247, 1251, 1255, 1259, 1263, 1267, 1271, 1275, 1279, 1283, 1287, 1291, 1295, 1299, 1303, 1307, 1311, 1315, 1319, 1323, 1327, 1331, 1335, 1339, 1343, 1347, 1351, 1355, 1359, 1363, 1367, 1371, 1375, 1379, 1383, 1387, 1391, 1395, 1399, 1403, 1407, 1411, 1415, 1419, 1423, 1427, 1431, 1435, 1439, 1443, 1447, 1451, 1455, 1459, 1463, 1467, 1471, 1475, 1479, 1483, 1487, 1491, 1495, 1499, 1503, 1507, 1511, 1515, 1519, 1523, 1527, 1531, 1535, 1539, 1543, 1547, 1551, 1555, 1559, 1563, 1567, 1571, 1575, 1579, 1583, 1587, 1591, 1595, 1599, 1603, 1607, 1611, 1615, 1619, 1623, 1627, 1631, 1635, 1639, 1643, 1647, 1651, 1655, 1659, 1663, 1667, 1671, 1675, 1679, 1683, 1687, 1691, 1695, 1699, 1703, 1707, 1711, 1715, 1719, 1723, 1727, 1731, 1735, 1739, 1743, 1747, 1751, 1755, 1759, 1763, 1767, 1771, 1775, 1779, 1783, 1787, 1791, 1795, 1799, 1803, 1807, 1811, 1815, 1819, 1823, 1827, 1831, 1835, 1839, 1843, 1847, 1851, 1855, 1859, 1863, 1867, 1871, 1875, 1879, 1883, 1887, 1891, 1895, 1899, 1903, 1907, 1911, 1915 or 1919. The antisense strand may have a nucleobase sequence comprising at least 15, at least 16, at least 17, at least 18, at least 19, at least 20, at least 21, at least 22, or at least 23 contiguous nucleobases, particularly 19, 20, 21, 22 or 23 contiguous nucleobases of any of SEQ ID NOs: 34, 35, 54, 55, 58, 59, 142, 143, 158, 159, 250, 251, 262, 263, 282, 283, 286, 287, 390, 391, 398, 399, 426, 427, 470, 471, 478, 479, 494, 495, 502, 503, 522, 523, 566, 567, 574, 575, 586, 587, 606, 607, 618, 619, 626, 627, 654, 655, 666, 667, 678, 679, 694, 695, 698, 699, 722, 723, 730, 731, 742, 743, 778, 779, 802, 803, 822, 823, 830, 831, 842, 843, 846, 847, 858, 859, 862, 863, 866, 867, 870, 871, 874, 875, 878, 879, 886, 887, 906, 907, 914, 915, 946, 947, 954, 955, 970, 971, 978, 979, 1006, 1007, 1018, 1019, 1022, 1023, 1026, 1027, 1034, 1035, 1038, 1039, 1042, 1043, 1058, 1059, 1082, 1083, 1086, 1087, 1102, 1103, 1118, 1119, 1126, 1127, 1142, 1143, 1146, 1147, 1150, 1151, 1154, 1155, 1158, 1159, 1182, 1183, 1186, 1187, 1190, 1191, 1210, 1211, 1214, 1215, 1254, 1255, 1270, 1271, 1274, 1275, 1278, 1279, 1282, 1283, 1294, 1295, 1298, 1299, 1302, 1303, 1310, 1311, 1330, 1331, 1334, 1335, 1346, 1347, 1354, 1355, 1358, 1359, 1362, 1363, 1366, 1367, 1602, 1603, 1614, 1615, 1618, 1619, 1626, 1627, 1630 or 1631. The antisense strand may have a nucleobase sequence comprising at least 15, at least 16, at least 17, at least 18, at least 19, at least 20, at least 21, at least 22, or at least 23 contiguous nucleobases, particularly 19, 20, 21, 22 or 23 contiguous nucleobases of any of SEQ ID NOs: 34, 54, 58, 142, 158, 250, 262, 282, 286, 390, 398, 426, 470, 478, 494, 502, 522, 566, 574, 586, 606, 618, 626, 654, 666, 678, 694, 698, 722, 730, 742, 778, 802, 822, 830, 842, 846, 858, 862, 866, 870, 874, 878, 886, 906, 914, 946, 954, 970, 978, 1006, 1018, 1022, 1026, 1034, 1038, 1042, 1058, 1082, 1086, 1102, 1118, 1126, 1142, 1146, 1150, 1154, 1158, 1182, 1186, 1190, 1210, 1214, 1254, 1270, 1274, 1278, 1282, 1294, 1298, 1302, 1310, 1330, 1334, 1346, 1354, 1358, 1362, 1366, 1602, 1614, 1618, 1626 or 1630. The antisense strand may have a nucleobase sequence comprising at least 15, at least 16, at least 17, at least 18, at least 19, at least 20, at least 21, at least 22, or at least 23 contiguous nucleobases, particularly 19, 20, 21, 22 or 23 contiguous nucleobases of any of SEQ ID NOs: 35, 55, 59, 143, 159, 251, 263, 283, 287, 391, 399, 427, 471, 479, 495, 503, 523, 567, 575, 587, 607, 619, 627, 655, 667, 679, 695, 699, 723, 731, 743, 779, 803, 823, 831, 843, 847, 859, 863, 867, 871, 875, 879, 887, 907, 915, 947, 955, 971, 979, 1007, 1019, 1023, 1027, 1035, 1039, 1043, 1059, 1083, 1087, 1103, 1119, 1127, 1143, 1147, 1151, 1155, 1159, 1183, 1187, 1191, 1211, 1215, 1255, 1271, 1275, 1279, 1283, 1295, 1299, 1303, 1311, 1331, 1335, 1347, 1355, 1359, 1363, 1367, 1603, 1615, 1619, 1627 or 1631. The antisense strand may have a nucleobase sequence comprising 19, 20, 21, 22 or 23 contiguous nucleobases of any of SEQ ID NOs: 2, 3, 6, 7, 10, 11, 14, 15, 18, 19, 22, 23, 26, 27, 30, 31, 34, 35, 38, 39, 42, 43, 46, 47, 50, 51, 54, 55, 58, 59, 62, 63, 66, 67, 70, 71, 74, 75, 78, 79, 82, 83, 86, 87, 90, 91, 94, 95, 98, 99, 102, 103, 106, 107, 110, 111, 114, 115, 118, 119, 122, 123, 126, 127, 130, 131, 134, 135, 138, 139, 142, 143, 146, 147, 150, 151, 154, 155, 158, 159, 162, 163, 166, 167, 170, 171, 174, 175, 178, 179, 182, 183, 186, 187, 190, 191, 194, 195, 198, 199, 202, 203, 206, 207, 210, 211, 214, 215, 218, 219, 222, 223, 226, 227, 230, 231, 234, 235, 238, 239, 242, 243, 246, 247, 250, 251, 254, 255, 258, 259, 262, 263, 266, 267, 270, 271, 274, 275, 278, 279, 282, 283, 286, 287, 290, 291, 294, 295, 298, 299, 302, 303, 306, 307, 310, 311, 314, 315, 318, 319, 322, 323, 326, 327, 330, 331, 334, 335, 338, 339, 342, 343, 346, 347, 350, 351, 354, 355, 358, 359, 362, 363, 366, 367, 370, 371, 374, 375, 378, 379, 382, 383, 386, 387, 390, 391, 394, 395, 398, 399, 402, 403, 406, 407, 410, 411, 414, 415, 418, 419, 422, 423, 426, 427, 430, 431, 434, 435, 438, 439, 442, 443, 446, 447, 450, 451, 454, 455, 458, 459, 462, 463, 466, 467, 470, 471, 474, 475, 478, 479, 482, 483, 486, 487, 490, 491, 494, 495, 498, 499, 502, 503, 506, 507, 510, 511, 514, 515, 518, 519, 522, 523, 526, 527, 530, 531, 534, 535, 538, 539, 542, 543, 546, 547, 550, 551, 554, 555, 558, 559, 562, 563, 566, 567, 570, 571, 574, 575, 578, 579, 582, 583, 586, 587, 590, 591, 594, 595, 598, 599, 602, 603, 606, 607, 610, 611, 614, 615, 618, 619, 622, 623, 626, 627, 630, 631, 634, 635, 638, 639, 642, 643, 646, 647, 650, 651, 654, 655, 658, 659, 662, 663, 666, 667, 670, 671, 674, 675, 678, 679, 682, 683, 686, 687, 690, 691, 694, 695, 698, 699, 702, 703, 706, 707, 710, 711, 714, 715, 718, 719, 722, 723, 726, 727, 730, 731, 734, 735, 738, 739, 742, 743, 746, 747, 750, 751, 754, 755, 758, 759, 762, 763, 766, 767, 770, 771, 774, 775, 778, 779, 782, 783, 786, 787, 790, 791, 794, 795, 798, 799, 802, 803, 806, 807, 810, 811, 814, 815, 818, 819, 822, 823, 826, 827, 830, 831, 834, 835, 838, 839, 842, 843, 846, 847, 850, 851, 854, 855, 858, 859, 862, 863, 866, 867, 870, 871, 874, 875, 878, 879, 882, 883, 886, 887, 890, 891, 894, 895, 898, 899, 902, 903, 906, 907, 910, 911, 914, 915, 918, 919, 922, 923, 926, 927, 930, 931, 934, 935, 938, 939, 942, 943, 946, 947, 950, 951, 954, 955, 958, 959, 962, 963, 966, 967, 970, 971, 974, 975, 978, 979, 982, 983, 986, 987, 990, 991, 994, 995, 998, 999, 1002, 1003, 1006, 1007, 1010, 1011, 1014, 1015, 1018, 1019, 1022, 1023, 1026, 1027, 1030, 1031, 1034, 1035, 1038, 1039, 1042, 1043, 1046, 1047, 1050, 1051, 1054, 1055, 1058, 1059, 1062, 1063, 1066, 1067, 1070, 1071, 1074, 1075, 1078, 1079, 1082, 1083, 1086, 1087, 1090, 1091, 1094, 1095, 1098, 1099, 1102, 1103, 1106, 1107, 1110, 1111, 1114, 1115, 1118, 1119, 1122, 1123, 1126, 1127, 1130, 1131, 1134, 1135, 1138, 1139, 1142, 1143, 1146, 1147, 1150, 1151, 1154, 1155, 1158, 1159, 1162, 1163, 1166, 1167, 1170, 1171, 1174, 1175, 1178, 1179, 1182, 1183, 1186, 1187, 1190, 1191, 1194, 1195, 1198, 1199, 1202, 1203, 1206, 1207, 1210, 1211, 1214, 1215, 1218, 1219, 1222, 1223, 1226, 1227, 1230, 1231, 1234, 1235, 1238, 1239, 1242, 1243, 1246, 1247, 1250, 1251, 1254, 1255, 1258, 1259, 1262, 1263, 1266, 1267, 1270, 1271, 1274, 1275, 1278, 1279, 1282, 1283, 1286, 1287, 1290, 1291, 1294, 1295, 1298, 1299, 1302, 1303, 1306, 1307, 1310, 1311, 1314, 1315, 1318, 1319, 1322, 1323, 1326, 1327, 1330, 1331, 1334, 1335, 1338, 1339, 1342, 1343, 1346, 1347, 1350, 1351, 1354, 1355, 1358, 1359, 1362, 1363, 1366, 1367, 1370, 1371, 1374, 1375, 1378, 1379, 1382, 1383, 1386, 1387, 1390, 1391, 1394, 1395, 1398, 1399, 1402, 1403, 1406, 1407, 1410, 1411, 1414, 1415, 1418, 1419, 1422, 1423, 1426, 1427, 1430, 1431, 1434, 1435, 1438, 1439, 1442, 1443, 1446, 1447, 1450, 1451, 1454, 1455, 1458, 1459, 1462, 1463, 1466, 1467, 1470, 1471, 1474, 1475, 1478, 1479, 1482, 1483, 1486, 1487, 1490, 1491, 1494, 1495, 1498, 1499, 1502, 1503, 1506, 1507, 1510, 1511, 1514, 1515, 1518, 1519, 1522, 1523, 1526, 1527, 1530, 1531, 1534, 1535, 1538, 1539, 1542, 1543, 1546, 1547, 1550, 1551, 1554, 1555, 1558, 1559, 1562, 1563, 1566, 1567, 1570, 1571, 1574, 1575, 1578, 1579, 1582, 1583, 1586, 1587, 1590, 1591, 1594, 1595, 1598, 1599, 1602, 1603, 1606, 1607, 1610, 1611, 1614, 1615, 1618, 1619, 1622, 1623, 1626, 1627, 1630, 1631, 1634, 1635, 1638, 1639, 1642, 1643, 1646, 1647, 1650, 1651, 1654, 1655, 1658, 1659, 1662, 1663, 1666, 1667, 1670, 1671, 1674, 1675, 1678, 1679, 1682, 1683, 1686, 1687, 1690, 1691, 1694, 1695, 1698, 1699, 1702, 1703, 1706, 1707, 1710, 1711, 1714, 1715, 1718, 1719, 1722, 1723, 1726, 1727, 1730, 1731, 1734, 1735, 1738, 1739, 1742, 1743, 1746, 1747, 1750, 1751, 1754, 1755, 1758, 1759, 1762, 1763, 1766, 1767, 1770, 1771, 1774, 1775, 1778, 1779, 1782, 1783, 1786, 1787, 1790, 1791, 1794, 1795, 1798, 1799, 1802, 1803, 1806, 1807, 1810, 1811, 1814, 1815, 1818, 1819, 1822, 1823, 1826, 1827, 1830, 1831, 1834, 1835, 1838, 1839, 1842, 1843, 1846, 1847, 1850, 1851, 1854, 1855, 1858, 1859, 1862, 1863, 1866, 1867, 1870, 1871, 1874, 1875, 1878, 1879, 1882, 1883, 1886, 1887, 1890, 1891, 1894, 1895, 1898, 1899, 1902, 1903, 1906, 1907, 1910, 1911, 1914, 1915, 1918 or 1919. The antisense strand may have a nucleobase sequence comprising 19, 20, 21, 22 or 23 contiguous nucleobases of any of SEQ ID NOs: 2, 6, 10, 14, 18, 22, 26, 30, 34, 38, 42, 46, 50, 54, 58, 62, 66, 70, 74, 78, 82, 86, 90, 94, 98, 102, 106, 110, 114, 118, 122, 126, 130, 134, 138, 142, 146, 150, 154, 158, 162, 166, 170, 174, 178, 182, 186, 190, 194, 198, 202, 206, 210, 214, 218, 222, 226, 230, 234, 238, 242, 246, 250, 254, 258, 262, 266, 270, 274, 278, 282, 286, 290, 294, 298, 302, 306, 310, 314, 318, 322, 326, 330, 334, 338, 342, 346, 350, 354, 358, 362, 366, 370, 374, 378, 382, 386, 390, 394, 398, 402, 406, 410, 414, 418, 422, 426, 430, 434, 438, 442, 446, 450, 454, 458, 462, 466, 470, 474, 478, 482, 486, 490, 494, 498, 502, 506, 510, 514, 518, 522, 526, 530, 534, 538, 542, 546, 550, 554, 558, 562, 566, 570, 574, 578, 582, 586, 590, 594, 598, 602, 606, 610, 614, 618, 622, 626, 630, 634, 638, 642, 646, 650, 654, 658, 662, 666, 670, 674, 678, 682, 686, 690, 694, 698, 702, 706, 710, 714, 718, 722, 726, 730, 734, 738, 742, 746, 750, 754, 758, 762, 766, 770, 774, 778, 782, 786, 790, 794, 798, 802, 806, 810, 814, 818, 822, 826, 830, 834, 838, 842, 846, 850, 854, 858, 862, 866, 870, 874, 878, 882, 886, 890, 894, 898, 902, 906, 910, 914, 918, 922, 926, 930, 934, 938, 942, 946, 950, 954, 958, 962, 966, 970, 974, 978, 982, 986, 990, 994, 998, 1002, 1006, 1010, 1014, 1018, 1022, 1026, 1030, 1034, 1038, 1042, 1046, 1050, 1054, 1058, 1062, 1066, 1070, 1074, 1078, 1082, 1086, 1090, 1094, 1098, 1102, 1106, 1110, 1114, 1118, 1122, 1126, 1130, 1134, 1138, 1142, 1146, 1150, 1154, 1158, 1162, 1166, 1170, 1174, 1178, 1182, 1186, 1190, 1194, 1198, 1202, 1206, 1210, 1214, 1218, 1222, 1226, 1230, 1234, 1238, 1242, 1246, 1250, 1254, 1258, 1262, 1266, 1270, 1274, 1278, 1282, 1286, 1290, 1294, 1298, 1302, 1306, 1310, 1314, 1318, 1322, 1326, 1330, 1334, 1338, 1342, 1346, 1350, 1354, 1358, 1362, 1366, 1370, 1374, 1378, 1382, 1386, 1390, 1394, 1398, 1402, 1406, 1410, 1414, 1418, 1422, 1426, 1430, 1434, 1438, 1442, 1446, 1450, 1454, 1458, 1462, 1466, 1470, 1474, 1478, 1482, 1486, 1490, 1494, 1498, 1502, 1506, 1510, 1514, 1518, 1522, 1526, 1530, 1534, 1538, 1542, 1546, 1550, 1554, 1558, 1562, 1566, 1570, 1574, 1578, 1582, 1586, 1590, 1594, 1598, 1602, 1606, 1610, 1614, 1618, 1622, 1626, 1630, 1634, 1638, 1642, 1646, 1650, 1654, 1658, 1662, 1666, 1670, 1674, 1678, 1682, 1686, 1690, 1694, 1698, 1702, 1706, 1710, 1714, 1718, 1722, 1726, 1730, 1734, 1738, 1742, 1746, 1750, 1754, 1758, 1762, 1766, 1770, 1774, 1778, 1782, 1786, 1790, 1794, 1798, 1802, 1806, 1810, 1814, 1818, 1822, 1826, 1830, 1834, 1838, 1842, 1846, 1850, 1854, 1858, 1862, 1866, 1870, 1874, 1878, 1882, 1886, 1890, 1894, 1898, 1902, 1906, 1910, 1914 or 1918. The antisense strand may have a nucleobase sequence comprising 19, 20, 21, 22 or 23 contiguous nucleobases of any of SEQ ID NOs: 3, 7, 11, 15, 19, 23, 27, 31, 35, 39, 43, 47, 51, 55, 59, 63, 67, 71, 75, 79, 83, 87, 91, 95, 99, 103, 107, 111, 115, 119, 123, 127, 131, 135, 139, 143, 147, 151, 155, 159, 163, 167, 171, 175, 179, 183, 187, 191, 195, 199, 203, 207, 211, 215, 219, 223, 227, 231, 235, 239, 243, 247, 251, 255, 259, 263, 267, 271, 275, 279, 283, 287, 291, 295, 299, 303, 307, 311, 315, 319, 323, 327, 331, 335, 339, 343, 347, 351, 355, 359, 363, 367, 371, 375, 379, 383, 387, 391, 395, 399, 403, 407, 411, 415, 419, 423, 427, 431, 435, 439, 443, 447, 451, 455, 459, 463, 467, 471, 475, 479, 483, 487, 491, 495, 499, 503, 507, 511, 515, 519, 523, 527, 531, 535, 539, 543, 547, 551, 555, 559, 563, 567, 571, 575, 579, 583, 587, 591, 595, 599, 603, 607, 611, 615, 619, 623, 627, 631, 635, 639, 643, 647, 651, 655, 659, 663, 667, 671, 675, 679, 683, 687, 691, 695, 699, 703, 707, 711, 715, 719, 723, 727, 731, 735, 739, 743, 747, 751, 755, 759, 763, 767, 771, 775, 779, 783, 787, 791, 795, 799, 803, 807, 811, 815, 819, 823, 827, 831, 835, 839, 843, 847, 851, 855, 859, 863, 867, 871, 875, 879, 883, 887, 891, 895, 899, 903, 907, 911, 915, 919, 923, 927, 931, 935, 939, 943, 947, 951, 955, 959, 963, 967, 971, 975, 979, 983, 987, 991, 995, 999, 1003, 1007, 1011, 1015, 1019, 1023, 1027, 1031, 1035, 1039, 1043, 1047, 1051, 1055, 1059, 1063, 1067, 1071, 1075, 1079, 1083, 1087, 1091, 1095, 1099, 1103, 1107, 1111, 1115, 1119, 1123, 1127, 1131, 1135, 1139, 1143, 1147, 1151, 1155, 1159, 1163, 1167, 1171, 1175, 1179, 1183, 1187, 1191, 1195, 1199, 1203, 1207, 1211, 1215, 1219, 1223, 1227, 1231, 1235, 1239, 1243, 1247, 1251, 1255, 1259, 1263, 1267, 1271, 1275, 1279, 1283, 1287, 1291, 1295, 1299, 1303, 1307, 1311, 1315, 1319, 1323, 1327, 1331, 1335, 1339, 1343, 1347, 1351, 1355, 1359, 1363, 1367, 1371, 1375, 1379, 1383, 1387, 1391, 1395, 1399, 1403, 1407, 1411, 1415, 1419, 1423, 1427, 1431, 1435, 1439, 1443, 1447, 1451, 1455, 1459, 1463, 1467, 1471, 1475, 1479, 1483, 1487, 1491, 1495, 1499, 1503, 1507, 1511, 1515, 1519, 1523, 1527, 1531, 1535, 1539, 1543, 1547, 1551, 1555, 1559, 1563, 1567, 1571, 1575, 1579, 1583, 1587, 1591, 1595, 1599, 1603, 1607, 1611, 1615, 1619, 1623, 1627, 1631, 1635, 1639, 1643, 1647, 1651, 1655, 1659, 1663, 1667, 1671, 1675, 1679, 1683, 1687, 1691, 1695, 1699, 1703, 1707, 1711, 1715, 1719, 1723, 1727, 1731, 1735, 1739, 1743, 1747, 1751, 1755, 1759, 1763, 1767, 1771, 1775, 1779, 1783, 1787, 1791, 1795, 1799, 1803, 1807, 1811, 1815, 1819, 1823, 1827, 1831, 1835, 1839, 1843, 1847, 1851, 1855, 1859, 1863, 1867, 1871, 1875, 1879, 1883, 1887, 1891, 1895, 1899, 1903, 1907, 1911, 1915 or 1919. The antisense strand may have a nucleobase sequence comprising 19, 20, 21, 22 or 23 contiguous nucleobases of any of SEQ ID NOs: 34, 35, 54, 55, 58, 59, 142, 143, 158, 159, 250, 251, 262, 263, 282, 283, 286, 287, 390, 391, 398, 399, 426, 427, 470, 471, 478, 479, 494, 495, 502, 503, 522, 523, 566, 567, 574, 575, 586, 587, 606, 607, 618, 619, 626, 627, 654, 655, 666, 667, 678, 679, 694, 695, 698, 699, 722, 723, 730, 731, 742, 743, 778, 779, 802, 803, 822, 823, 830, 831, 842, 843, 846, 847, 858, 859, 862, 863, 866, 867, 870, 871, 874, 875, 878, 879, 886, 887, 906, 907, 914, 915, 946, 947, 954, 955, 970, 971, 978, 979, 1006, 1007, 1018, 1019, 1022, 1023, 1026, 1027, 1034, 1035, 1038, 1039, 1042, 1043, 1058, 1059, 1082, 1083, 1086, 1087, 1102, 1103, 1118, 1119, 1126, 1127, 1142, 1143, 1146, 1147, 1150, 1151, 1154, 1155, 1158, 1159, 1182, 1183, 1186, 1187, 1190, 1191, 1210, 1211, 1214, 1215, 1254, 1255, 1270, 1271, 1274, 1275, 1278, 1279, 1282, 1283, 1294, 1295, 1298, 1299, 1302, 1303, 1310, 1311, 1330, 1331, 1334, 1335, 1346, 1347, 1354, 1355, 1358, 1359, 1362, 1363, 1366, 1367, 1602, 1603, 1614, 1615, 1618, 1619, 1626, 1627, 1630 or 1631. The antisense strand may have a nucleobase sequence comprising 19, 20, 21, 22 or 23 contiguous nucleobases of any of SEQ ID NOs: 34, 54, 58, 142, 158, 250, 262, 282, 286, 390, 398, 426, 470, 478, 494, 502, 522, 566, 574, 586, 606, 618, 626, 654, 666, 678, 694, 698, 722, 730, 742, 778, 802, 822, 830, 842, 846, 858, 862, 866, 870, 874, 878, 886, 906, 914, 946, 954, 970, 978, 1006, 1018, 1022, 1026, 1034, 1038, 1042, 1058, 1082, 1086, 1102, 1118, 1126, 1142, 1146, 1150, 1154, 1158, 1182, 1186, 1190, 1210, 1214, 1254, 1270, 1274, 1278, 1282, 1294, 1298, 1302, 1310, 1330, 1334, 1346, 1354, 1358, 1362, 1366, 1602, 1614, 1618, 1626 or 1630. The antisense strand may have a nucleobase sequence comprising 19, 20, 21, 22 or 23 contiguous nucleobases of any of SEQ ID NOs: 35, 55, 59, 143, 159, 251, 263, 283, 287, 391, 399, 427, 471, 479, 495, 503, 523, 567, 575, 587, 607, 619, 627, 655, 667, 679, 695, 699, 723, 731, 743, 779, 803, 823, 831, 843, 847, 859, 863, 867, 871, 875, 879, 887, 907, 915, 947, 955, 971, 979, 1007, 1019, 1023, 1027, 1035, 1039, 1043, 1059, 1083, 1087, 1103, 1119, 1127, 1143, 1147, 1151, 1155, 1159, 1183, 1187, 1191, 1211, 1215, 1255, 1271, 1275, 1279, 1283, 1295, 1299, 1303, 1311, 1331, 1335, 1347, 1355, 1359, 1363, 1367, 1603, 1615, 1619, 1627 or 1631. The nucleobase sequence of the antisense strand may comprise or consist of a nucleobase sequence that is identical to any of SEQ ID NOs: 2, 3, 6, 7, 10, 11, 14, 15, 18, 19, 22, 23, 26, 27, 30, 31, 34, 35, 38, 39, 42, 43, 46, 47, 50, 51, 54, 55, 58, 59, 62, 63, 66, 67, 70, 71, 74, 75, 78, 79, 82, 83, 86, 87, 90, 91, 94, 95, 98, 99, 102, 103, 106, 107, 110, 111, 114, 115, 118, 119, 122, 123, 126, 127, 130, 131, 134, 135, 138, 139, 142, 143, 146, 147, 150, 151, 154, 155, 158, 159, 162, 163, 166, 167, 170, 171, 174, 175, 178, 179, 182, 183, 186, 187, 190, 191, 194, 195, 198, 199, 202, 203, 206, 207, 210, 211, 214, 215, 218, 219, 222, 223, 226, 227, 230, 231, 234, 235, 238, 239, 242, 243, 246, 247, 250, 251, 254, 255, 258, 259, 262, 263, 266, 267, 270, 271, 274, 275, 278, 279, 282, 283, 286, 287, 290, 291, 294, 295, 298, 299, 302, 303, 306, 307, 310, 311, 314, 315, 318, 319, 322, 323, 326, 327, 330, 331, 334, 335, 338, 339, 342, 343, 346, 347, 350, 351, 354, 355, 358, 359, 362, 363, 366, 367, 370, 371, 374, 375, 378, 379, 382, 383, 386, 387, 390, 391, 394, 395, 398, 399, 402, 403, 406, 407, 410, 411, 414, 415, 418, 419, 422, 423, 426, 427, 430, 431, 434, 435, 438, 439, 442, 443, 446, 447, 450, 451, 454, 455, 458, 459, 462, 463, 466, 467, 470, 471, 474, 475, 478, 479, 482, 483, 486, 487, 490, 491, 494, 495, 498, 499, 502, 503, 506, 507, 510, 511, 514, 515, 518, 519, 522, 523, 526, 527, 530, 531, 534, 535, 538, 539, 542, 543, 546, 547, 550, 551, 554, 555, 558, 559, 562, 563, 566, 567, 570, 571, 574, 575, 578, 579, 582, 583, 586, 587, 590, 591, 594, 595, 598, 599, 602, 603, 606, 607, 610, 611, 614, 615, 618, 619, 622, 623, 626, 627, 630, 631, 634, 635, 638, 639, 642, 643, 646, 647, 650, 651, 654, 655, 658, 659, 662, 663, 666, 667, 670, 671, 674, 675, 678, 679, 682, 683, 686, 687, 690, 691, 694, 695, 698, 699, 702, 703, 706, 707, 710, 711, 714, 715, 718, 719, 722, 723, 726, 727, 730, 731, 734, 735, 738, 739, 742, 743, 746, 747, 750, 751, 754, 755, 758, 759, 762, 763, 766, 767, 770, 771, 774, 775, 778, 779, 782, 783, 786, 787, 790, 791, 794, 795, 798, 799, 802, 803, 806, 807, 810, 811, 814, 815, 818, 819, 822, 823, 826, 827, 830, 831, 834, 835, 838, 839, 842, 843, 846, 847, 850, 851, 854, 855, 858, 859, 862, 863, 866, 867, 870, 871, 874, 875, 878, 879, 882, 883, 886, 887, 890, 891, 894, 895, 898, 899, 902, 903, 906, 907, 910, 911, 914, 915, 918, 919, 922, 923, 926, 927, 930, 931, 934, 935, 938, 939, 942, 943, 946, 947, 950, 951, 954, 955, 958, 959, 962, 963, 966, 967, 970, 971, 974, 975, 978, 979, 982, 983, 986, 987, 990, 991, 994, 995, 998, 999, 1002, 1003, 1006, 1007, 1010, 1011, 1014, 1015, 1018, 1019, 1022, 1023, 1026, 1027, 1030, 1031, 1034, 1035, 1038, 1039, 1042, 1043, 1046, 1047, 1050, 1051, 1054, 1055, 1058, 1059, 1062, 1063, 1066, 1067, 1070, 1071, 1074, 1075, 1078, 1079, 1082, 1083, 1086, 1087, 1090, 1091, 1094, 1095, 1098, 1099, 1102, 1103, 1106, 1107, 1110, 1111, 1114, 1115, 1118, 1119, 1122, 1123, 1126, 1127, 1130, 1131, 1134, 1135, 1138, 1139, 1142, 1143, 1146, 1147, 1150, 1151, 1154, 1155, 1158, 1159, 1162, 1163, 1166, 1167, 1170, 1171, 1174, 1175, 1178, 1179, 1182, 1183, 1186, 1187, 1190, 1191, 1194, 1195, 1198, 1199, 1202, 1203, 1206, 1207, 1210, 1211, 1214, 1215, 1218, 1219, 1222, 1223, 1226, 1227, 1230, 1231, 1234, 1235, 1238, 1239, 1242, 1243, 1246, 1247, 1250, 1251, 1254, 1255, 1258, 1259, 1262, 1263, 1266, 1267, 1270, 1271, 1274, 1275, 1278, 1279, 1282, 1283, 1286, 1287, 1290, 1291, 1294, 1295, 1298, 1299, 1302, 1303, 1306, 1307, 1310, 1311, 1314, 1315, 1318, 1319, 1322, 1323, 1326, 1327, 1330, 1331, 1334, 1335, 1338, 1339, 1342, 1343, 1346, 1347, 1350, 1351, 1354, 1355, 1358, 1359, 1362, 1363, 1366, 1367, 1370, 1371, 1374, 1375, 1378, 1379, 1382, 1383, 1386, 1387, 1390, 1391, 1394, 1395, 1398, 1399, 1402, 1403, 1406, 1407, 1410, 1411, 1414, 1415, 1418, 1419, 1422, 1423, 1426, 1427, 1430, 1431, 1434, 1435, 1438, 1439, 1442, 1443, 1446, 1447, 1450, 1451, 1454, 1455, 1458, 1459, 1462, 1463, 1466, 1467, 1470, 1471, 1474, 1475, 1478, 1479, 1482, 1483, 1486, 1487, 1490, 1491, 1494, 1495, 1498, 1499, 1502, 1503, 1506, 1507, 1510, 1511, 1514, 1515, 1518, 1519, 1522, 1523, 1526, 1527, 1530, 1531, 1534, 1535, 1538, 1539, 1542, 1543, 1546, 1547, 1550, 1551, 1554, 1555, 1558, 1559, 1562, 1563, 1566, 1567, 1570, 1571, 1574, 1575, 1578, 1579, 1582, 1583, 1586, 1587, 1590, 1591, 1594, 1595, 1598, 1599, 1602, 1603, 1606, 1607, 1610, 1611, 1614, 1615, 1618, 1619, 1622, 1623, 1626, 1627, 1630, 1631, 1634, 1635, 1638, 1639, 1642, 1643, 1646, 1647, 1650, 1651, 1654, 1655, 1658, 1659, 1662, 1663, 1666, 1667, 1670, 1671, 1674, 1675, 1678, 1679, 1682, 1683, 1686, 1687, 1690, 1691, 1694, 1695, 1698, 1699, 1702, 1703, 1706, 1707, 1710, 1711, 1714, 1715, 1718, 1719, 1722, 1723, 1726, 1727, 1730, 1731, 1734, 1735, 1738, 1739, 1742, 1743, 1746, 1747, 1750, 1751, 1754, 1755, 1758, 1759, 1762, 1763, 1766, 1767, 1770, 1771, 1774, 1775, 1778, 1779, 1782, 1783, 1786, 1787, 1790, 1791, 1794, 1795, 1798, 1799, 1802, 1803, 1806, 1807, 1810, 1811, 1814, 1815, 1818, 1819, 1822, 1823, 1826, 1827, 1830, 1831, 1834, 1835, 1838, 1839, 1842, 1843, 1846, 1847, 1850, 1851, 1854, 1855, 1858, 1859, 1862, 1863, 1866, 1867, 1870, 1871, 1874, 1875, 1878, 1879, 1882, 1883, 1886, 1887, 1890, 1891, 1894, 1895, 1898, 1899, 1902, 1903, 1906, 1907, 1910, 1911, 1914, 1915, 1918 or 1919. The nucleobase sequence of the antisense strand may comprise or consist of a nucleobase sequence that is identical to any of SEQ ID NOs: 2, 6, 10, 14, 18, 22, 26, 30, 34, 38, 42, 46, 50, 54, 58, 62, 66, 70, 74, 78, 82, 86, 90, 94, 98, 102, 106, 110, 114, 118, 122, 126, 130, 134, 138, 142, 146, 150, 154, 158, 162, 166, 170, 174, 178, 182, 186, 190, 194, 198, 202, 206, 210, 214, 218, 222, 226, 230, 234, 238, 242, 246, 250, 254, 258, 262, 266, 270, 274, 278, 282, 286, 290, 294, 298, 302, 306, 310, 314, 318, 322, 326, 330, 334, 338, 342, 346, 350, 354, 358, 362, 366, 370, 374, 378, 382, 386, 390, 394, 398, 402, 406, 410, 414, 418, 422, 426, 430, 434, 438, 442, 446, 450, 454, 458, 462, 466, 470, 474, 478, 482, 486, 490, 494, 498, 502, 506, 510, 514, 518, 522, 526, 530, 534, 538, 542, 546, 550, 554, 558, 562, 566, 570, 574, 578, 582, 586, 590, 594, 598, 602, 606, 610, 614, 618, 622, 626, 630, 634, 638, 642, 646, 650, 654, 658, 662, 666, 670, 674, 678, 682, 686, 690, 694, 698, 702, 706, 710, 714, 718, 722, 726, 730, 734, 738, 742, 746, 750, 754, 758, 762, 766, 770, 774, 778, 782, 786, 790, 794, 798, 802, 806, 810, 814, 818, 822, 826, 830, 834, 838, 842, 846, 850, 854, 858, 862, 866, 870, 874, 878, 882, 886, 890, 894, 898, 902, 906, 910, 914, 918, 922, 926, 930, 934, 938, 942, 946, 950, 954, 958, 962, 966, 970, 974, 978, 982, 986, 990, 994, 998, 1002, 1006, 1010, 1014, 1018, 1022, 1026, 1030, 1034, 1038, 1042, 1046, 1050, 1054, 1058, 1062, 1066, 1070, 1074, 1078, 1082, 1086, 1090, 1094, 1098, 1102, 1106, 1110, 1114, 1118, 1122, 1126, 1130, 1134, 1138, 1142, 1146, 1150, 1154, 1158, 1162, 1166, 1170, 1174, 1178, 1182, 1186, 1190, 1194, 1198, 1202, 1206, 1210, 1214, 1218, 1222, 1226, 1230, 1234, 1238, 1242, 1246, 1250, 1254, 1258, 1262, 1266, 1270, 1274, 1278, 1282, 1286, 1290, 1294, 1298, 1302, 1306, 1310, 1314, 1318, 1322, 1326, 1330, 1334, 1338, 1342, 1346, 1350, 1354, 1358, 1362, 1366, 1370, 1374, 1378, 1382, 1386, 1390, 1394, 1398, 1402, 1406, 1410, 1414, 1418, 1422, 1426, 1430, 1434, 1438, 1442, 1446, 1450, 1454, 1458, 1462, 1466, 1470, 1474, 1478, 1482, 1486, 1490, 1494, 1498, 1502, 1506, 1510, 1514, 1518, 1522, 1526, 1530, 1534, 1538, 1542, 1546, 1550, 1554, 1558, 1562, 1566, 1570, 1574, 1578, 1582, 1586, 1590, 1594, 1598, 1602, 1606, 1610, 1614, 1618, 1622, 1626, 1630, 1634, 1638, 1642, 1646, 1650, 1654, 1658, 1662, 1666, 1670, 1674, 1678, 1682, 1686, 1690, 1694, 1698, 1702, 1706, 1710, 1714, 1718, 1722, 1726, 1730, 1734, 1738, 1742, 1746, 1750, 1754, 1758, 1762, 1766, 1770, 1774, 1778, 1782, 1786, 1790, 1794, 1798, 1802, 1806, 1810, 1814, 1818, 1822, 1826, 1830, 1834, 1838, 1842, 1846, 1850, 1854, 1858, 1862, 1866, 1870, 1874, 1878, 1882, 1886, 1890, 1894, 1898, 1902, 1906, 1910, 1914 or 1918. The nucleobase sequence of the antisense strand may comprise or consist of a nucleobase sequence that is identical to any of SEQ ID NOs: 3, 7, 11, 15, 19, 23, 27, 31, 35, 39, 43, 47, 51, 55, 59, 63, 67, 71, 75, 79, 83, 87, 91, 95, 99, 103, 107, 111, 115, 119, 123, 127, 131, 135, 139, 143, 147, 151, 155, 159, 163, 167, 171, 175, 179, 183, 187, 191, 195, 199, 203, 207, 211, 215, 219, 223, 227, 231, 235, 239, 243, 247, 251, 255, 259, 263, 267, 271, 275, 279, 283, 287, 291, 295, 299, 303, 307, 311, 315, 319, 323, 327, 331, 335, 339, 343, 347, 351, 355, 359, 363, 367, 371, 375, 379, 383, 387, 391, 395, 399, 403, 407, 411, 415, 419, 423, 427, 431, 435, 439, 443, 447, 451, 455, 459, 463, 467, 471, 475, 479, 483, 487, 491, 495, 499, 503, 507, 511, 515, 519, 523, 527, 531, 535, 539, 543, 547, 551, 555, 559, 563, 567, 571, 575, 579, 583, 587, 591, 595, 599, 603, 607, 611, 615, 619, 623, 627, 631, 635, 639, 643, 647, 651, 655, 659, 663, 667, 671, 675, 679, 683, 687, 691, 695, 699, 703, 707, 711, 715, 719, 723, 727, 731, 735, 739, 743, 747, 751, 755, 759, 763, 767, 771, 775, 779, 783, 787, 791, 795, 799, 803, 807, 811, 815, 819, 823, 827, 831, 835, 839, 843, 847, 851, 855, 859, 863, 867, 871, 875, 879, 883, 887, 891, 895, 899, 903, 907, 911, 915, 919, 923, 927, 931, 935, 939, 943, 947, 951, 955, 959, 963, 967, 971, 975, 979, 983, 987, 991, 995, 999, 1003, 1007, 1011, 1015, 1019, 1023, 1027, 1031, 1035, 1039, 1043, 1047, 1051, 1055, 1059, 1063, 1067, 1071, 1075, 1079, 1083, 1087, 1091, 1095, 1099, 1103, 1107, 1111, 1115, 1119, 1123, 1127, 1131, 1135, 1139, 1143, 1147, 1151, 1155, 1159, 1163, 1167, 1171, 1175, 1179, 1183, 1187, 1191, 1195, 1199, 1203, 1207, 1211, 1215, 1219, 1223, 1227, 1231, 1235, 1239, 1243, 1247, 1251, 1255, 1259, 1263, 1267, 1271, 1275, 1279, 1283, 1287, 1291, 1295, 1299, 1303, 1307, 1311, 1315, 1319, 1323, 1327, 1331, 1335, 1339, 1343, 1347, 1351, 1355, 1359, 1363, 1367, 1371, 1375, 1379, 1383, 1387, 1391, 1395, 1399, 1403, 1407, 1411, 1415, 1419, 1423, 1427, 1431, 1435, 1439, 1443, 1447, 1451, 1455, 1459, 1463, 1467, 1471, 1475, 1479, 1483, 1487, 1491, 1495, 1499, 1503, 1507, 1511, 1515, 1519, 1523, 1527, 1531, 1535, 1539, 1543, 1547, 1551, 1555, 1559, 1563, 1567, 1571, 1575, 1579, 1583, 1587, 1591, 1595, 1599, 1603, 1607, 1611, 1615, 1619, 1623, 1627, 1631, 1635, 1639, 1643, 1647, 1651, 1655, 1659, 1663, 1667, 1671, 1675, 1679, 1683, 1687, 1691, 1695, 1699, 1703, 1707, 1711, 1715, 1719, 1723, 1727, 1731, 1735, 1739, 1743, 1747, 1751, 1755, 1759, 1763, 1767, 1771, 1775, 1779, 1783, 1787, 1791, 1795, 1799, 1803, 1807, 1811, 1815, 1819, 1823, 1827, 1831, 1835, 1839, 1843, 1847, 1851, 1855, 1859, 1863, 1867, 1871, 1875, 1879, 1883, 1887, 1891, 1895, 1899, 1903, 1907, 1911, 1915 or 1919. The nucleobase sequence of the antisense strand may comprise or consist of a nucleobase sequence that is identical to any of SEQ ID NOs: 34, 35, 54, 55, 58, 59, 142, 143, 158, 159, 250, 251, 262, 263, 282, 283, 286, 287, 390, 391, 398, 399, 426, 427, 470, 471, 478, 479, 494, 495, 502, 503, 522, 523, 566, 567, 574, 575, 586, 587, 606, 607, 618, 619, 626, 627, 654, 655, 666, 667, 678, 679, 694, 695, 698, 699, 722, 723, 730, 731, 742, 743, 778, 779, 802, 803, 822, 823, 830, 831, 842, 843, 846, 847, 858, 859, 862, 863, 866, 867, 870, 871, 874, 875, 878, 879, 886, 887, 906, 907, 914, 915, 946, 947, 954, 955, 970, 971, 978, 979, 1006, 1007, 1018, 1019, 1022, 1023, 1026, 1027, 1034, 1035, 1038, 1039, 1042, 1043, 1058, 1059, 1082, 1083, 1086, 1087, 1102, 1103, 1118, 1119, 1126, 1127, 1142, 1143, 1146, 1147, 1150, 1151, 1154, 1155, 1158, 1159, 1182, 1183, 1186, 1187, 1190, 1191, 1210, 1211, 1214, 1215, 1254, 1255, 1270, 1271, 1274, 1275, 1278, 1279, 1282, 1283, 1294, 1295, 1298, 1299, 1302, 1303, 1310, 1311, 1330, 1331, 1334, 1335, 1346, 1347, 1354, 1355, 1358, 1359, 1362, 1363, 1366, 1367, 1602, 1603, 1614, 1615, 1618, 1619, 1626, 1627, 1630 or 1631. The nucleobase sequence of the antisense strand may comprise or consist of a nucleobase sequence that is identical to any of SEQ ID NOs: 34, 54, 58, 142, 158, 250, 262, 282, 286, 390, 398, 426, 470, 478, 494, 502, 522, 566, 574, 586, 606, 618, 626, 654, 666, 678, 694, 698, 722, 730, 742, 778, 802, 822, 830, 842, 846, 858, 862, 866, 870, 874, 878, 886, 906, 914, 946, 954, 970, 978, 1006, 1018, 1022, 1026, 1034, 1038, 1042, 1058, 1082, 1086, 1102, 1118, 1126, 1142, 1146, 1150, 1154, 1158, 1182, 1186, 1190, 1210, 1214, 1254, 1270, 1274, 1278, 1282, 1294, 1298, 1302, 1310, 1330, 1334, 1346, 1354, 1358, 1362, 1366, 1602, 1614, 1618, 1626 or 1630. The nucleobase sequence of the antisense strand may comprise or consist of a nucleobase sequence that is identical to any of SEQ ID NOs: 35, 55, 59, 143, 159, 251, 263, 283, 287, 391, 399, 427, 471, 479, 495, 503, 523, 567, 575, 587, 607, 619, 627, 655, 667, 679, 695, 699, 723, 731, 743, 779, 803, 823, 831, 843, 847, 859, 863, 867, 871, 875, 879, 887, 907, 915, 947, 955, 971, 979, 1007, 1019, 1023, 1027, 1035, 1039, 1043, 1059, 1083, 1087, 1103, 1119, 1127, 1143, 1147, 1151, 1155, 1159, 1183, 1187, 1191, 1211, 1215, 1255, 1271, 1275, 1279, 1283, 1295, 1299, 1303, 1311, 1331, 1335, 1347, 1355, 1359, 1363, 1367, 1603, 1615, 1619, 1627 or 1631. The nucleobase sequence of the antisense strand may consist of a nucleobase sequence that is identical to any of SEQ ID NOs: 2, 3, 6, 7, 10, 11, 14, 15, 18, 19, 22, 23, 26, 27, 30, 31, 34, 35, 38, 39, 42, 43, 46, 47, 50, 51, 54, 55, 58, 59, 62, 63, 66, 67, 70, 71, 74, 75, 78, 79, 82, 83, 86, 87, 90, 91, 94, 95, 98, 99, 102, 103, 106, 107, 110, 111, 114, 115, 118, 119, 122, 123, 126, 127, 130, 131, 134, 135, 138, 139, 142, 143, 146, 147, 150, 151, 154, 155, 158, 159, 162, 163, 166, 167, 170, 171, 174, 175, 178, 179, 182, 183, 186, 187, 190, 191, 194, 195, 198, 199, 202, 203, 206, 207, 210, 211, 214, 215, 218, 219, 222, 223, 226, 227, 230, 231, 234, 235, 238, 239, 242, 243, 246, 247, 250, 251, 254, 255, 258, 259, 262, 263, 266, 267, 270, 271, 274, 275, 278, 279, 282, 283, 286, 287, 290, 291, 294, 295, 298, 299, 302, 303, 306, 307, 310, 311, 314, 315, 318, 319, 322, 323, 326, 327, 330, 331, 334, 335, 338, 339, 342, 343, 346, 347, 350, 351, 354, 355, 358, 359, 362, 363, 366, 367, 370, 371, 374, 375, 378, 379, 382, 383, 386, 387, 390, 391, 394, 395, 398, 399, 402, 403, 406, 407, 410, 411, 414, 415, 418, 419, 422, 423, 426, 427, 430, 431, 434, 435, 438, 439, 442, 443, 446, 447, 450, 451, 454, 455, 458, 459, 462, 463, 466, 467, 470, 471, 474, 475, 478, 479, 482, 483, 486, 487, 490, 491, 494, 495, 498, 499, 502, 503, 506, 507, 510, 511, 514, 515, 518, 519, 522, 523, 526, 527, 530, 531, 534, 535, 538, 539, 542, 543, 546, 547, 550, 551, 554, 555, 558, 559, 562, 563, 566, 567, 570, 571, 574, 575, 578, 579, 582, 583, 586, 587, 590, 591, 594, 595, 598, 599, 602, 603, 606, 607, 610, 611, 614, 615, 618, 619, 622, 623, 626, 627, 630, 631, 634, 635, 638, 639, 642, 643, 646, 647, 650, 651, 654, 655, 658, 659, 662, 663, 666, 667, 670, 671, 674, 675, 678, 679, 682, 683, 686, 687, 690, 691, 694, 695, 698, 699, 702, 703, 706, 707, 710, 711, 714, 715, 718, 719, 722, 723, 726, 727, 730, 731, 734, 735, 738, 739, 742, 743, 746, 747, 750, 751, 754, 755, 758, 759, 762, 763, 766, 767, 770, 771, 774, 775, 778, 779, 782, 783, 786, 787, 790, 791, 794, 795, 798, 799, 802, 803, 806, 807, 810, 811, 814, 815, 818, 819, 822, 823, 826, 827, 830, 831, 834, 835, 838, 839, 842, 843, 846, 847, 850, 851, 854, 855, 858, 859, 862, 863, 866, 867, 870, 871, 874, 875, 878, 879, 882, 883, 886, 887, 890, 891, 894, 895, 898, 899, 902, 903, 906, 907, 910, 911, 914, 915, 918, 919, 922, 923, 926, 927, 930, 931, 934, 935, 938, 939, 942, 943, 946, 947, 950, 951, 954, 955, 958, 959, 962, 963, 966, 967, 970, 971, 974, 975, 978, 979, 982, 983, 986, 987, 990, 991, 994, 995, 998, 999, 1002, 1003, 1006, 1007, 1010, 1011, 1014, 1015, 1018, 1019, 1022, 1023, 1026, 1027, 1030, 1031, 1034, 1035, 1038, 1039, 1042, 1043, 1046, 1047, 1050, 1051, 1054, 1055, 1058, 1059, 1062, 1063, 1066, 1067, 1070, 1071, 1074, 1075, 1078, 1079, 1082, 1083, 1086, 1087, 1090, 1091, 1094, 1095, 1098, 1099, 1102, 1103, 1106, 1107, 1110, 1111, 1114, 1115, 1118, 1119, 1122, 1123, 1126, 1127, 1130, 1131, 1134, 1135, 1138, 1139, 1142, 1143, 1146, 1147, 1150, 1151, 1154, 1155, 1158, 1159, 1162, 1163, 1166, 1167, 1170, 1171, 1174, 1175, 1178, 1179, 1182, 1183, 1186, 1187, 1190, 1191, 1194, 1195, 1198, 1199, 1202, 1203, 1206, 1207, 1210, 1211, 1214, 1215, 1218, 1219, 1222, 1223, 1226, 1227, 1230, 1231, 1234, 1235, 1238, 1239, 1242, 1243, 1246, 1247, 1250, 1251, 1254, 1255, 1258, 1259, 1262, 1263, 1266, 1267, 1270, 1271, 1274, 1275, 1278, 1279, 1282, 1283, 1286, 1287, 1290, 1291, 1294, 1295, 1298, 1299, 1302, 1303, 1306, 1307, 1310, 1311, 1314, 1315, 1318, 1319, 1322, 1323, 1326, 1327, 1330, 1331, 1334, 1335, 1338, 1339, 1342, 1343, 1346, 1347, 1350, 1351, 1354, 1355, 1358, 1359, 1362, 1363, 1366, 1367, 1370, 1371, 1374, 1375, 1378, 1379, 1382, 1383, 1386, 1387, 1390, 1391, 1394, 1395, 1398, 1399, 1402, 1403, 1406, 1407, 1410, 1411, 1414, 1415, 1418, 1419, 1422, 1423, 1426, 1427, 1430, 1431, 1434, 1435, 1438, 1439, 1442, 1443, 1446, 1447, 1450, 1451, 1454, 1455, 1458, 1459, 1462, 1463, 1466, 1467, 1470, 1471, 1474, 1475, 1478, 1479, 1482, 1483, 1486, 1487, 1490, 1491, 1494, 1495, 1498, 1499, 1502, 1503, 1506, 1507, 1510, 1511, 1514, 1515, 1518, 1519, 1522, 1523, 1526, 1527, 1530, 1531, 1534, 1535, 1538, 1539, 1542, 1543, 1546, 1547, 1550, 1551, 1554, 1555, 1558, 1559, 1562, 1563, 1566, 1567, 1570, 1571, 1574, 1575, 1578, 1579, 1582, 1583, 1586, 1587, 1590, 1591, 1594, 1595, 1598, 1599, 1602, 1603, 1606, 1607, 1610, 1611, 1614, 1615, 1618, 1619, 1622, 1623, 1626, 1627, 1630, 1631, 1634, 1635, 1638, 1639, 1642, 1643, 1646, 1647, 1650, 1651, 1654, 1655, 1658, 1659, 1662, 1663, 1666, 1667, 1670, 1671, 1674, 1675, 1678, 1679, 1682, 1683, 1686, 1687, 1690, 1691, 1694, 1695, 1698, 1699, 1702, 1703, 1706, 1707, 1710, 1711, 1714, 1715, 1718, 1719, 1722, 1723, 1726, 1727, 1730, 1731, 1734, 1735, 1738, 1739, 1742, 1743, 1746, 1747, 1750, 1751, 1754, 1755, 1758, 1759, 1762, 1763, 1766, 1767, 1770, 1771, 1774, 1775, 1778, 1779, 1782, 1783, 1786, 1787, 1790, 1791, 1794, 1795, 1798, 1799, 1802, 1803, 1806, 1807, 1810, 1811, 1814, 1815, 1818, 1819, 1822, 1823, 1826, 1827, 1830, 1831, 1834, 1835, 1838, 1839, 1842, 1843, 1846, 1847, 1850, 1851, 1854, 1855, 1858, 1859, 1862, 1863, 1866, 1867, 1870, 1871, 1874, 1875, 1878, 1879, 1882, 1883, 1886, 1887, 1890, 1891, 1894, 1895, 1898, 1899, 1902, 1903, 1906, 1907, 1910, 1911, 1914, 1915, 1918 or 1919. The nucleobase sequence of the antisense strand may consist of a nucleobase sequence that is identical to any of SEQ ID NOs: 2, 6, 10, 14, 18, 22, 26, 30, 34, 38, 42, 46, 50, 54, 58, 62, 66, 70, 74, 78, 82, 86, 90, 94, 98, 102, 106, 110, 114, 118, 122, 126, 130, 134, 138, 142, 146, 150, 154, 158, 162, 166, 170, 174, 178, 182, 186, 190, 194, 198, 202, 206, 210, 214, 218, 222, 226, 230, 234, 238, 242, 246, 250, 254, 258, 262, 266, 270, 274, 278, 282, 286, 290, 294, 298, 302, 306, 310, 314, 318, 322, 326, 330, 334, 338, 342, 346, 350, 354, 358, 362, 366, 370, 374, 378, 382, 386, 390, 394, 398, 402, 406, 410, 414, 418, 422, 426, 430, 434, 438, 442, 446, 450, 454, 458, 462, 466, 470, 474, 478, 482, 486, 490, 494, 498, 502, 506, 510, 514, 518, 522, 526, 530, 534, 538, 542, 546, 550, 554, 558, 562, 566, 570, 574, 578, 582, 586, 590, 594, 598, 602, 606, 610, 614, 618, 622, 626, 630, 634, 638, 642, 646, 650, 654, 658, 662, 666, 670, 674, 678, 682, 686, 690, 694, 698, 702, 706, 710, 714, 718, 722, 726, 730, 734, 738, 742, 746, 750, 754, 758, 762, 766, 770, 774, 778, 782, 786, 790, 794, 798, 802, 806, 810, 814, 818, 822, 826, 830, 834, 838, 842, 846, 850, 854, 858, 862, 866, 870, 874, 878, 882, 886, 890, 894, 898, 902, 906, 910, 914, 918, 922, 926, 930, 934, 938, 942, 946, 950, 954, 958, 962, 966, 970, 974, 978, 982, 986, 990, 994, 998, 1002, 1006, 1010, 1014, 1018, 1022, 1026, 1030, 1034, 1038, 1042, 1046, 1050, 1054, 1058, 1062, 1066, 1070, 1074, 1078, 1082, 1086, 1090, 1094, 1098, 1102, 1106, 1110, 1114, 1118, 1122, 1126, 1130, 1134, 1138, 1142, 1146, 1150, 1154, 1158, 1162, 1166, 1170, 1174, 1178, 1182, 1186, 1190, 1194, 1198, 1202, 1206, 1210, 1214, 1218, 1222, 1226, 1230, 1234, 1238, 1242, 1246, 1250, 1254, 1258, 1262, 1266, 1270, 1274, 1278, 1282, 1286, 1290, 1294, 1298, 1302, 1306, 1310, 1314, 1318, 1322, 1326, 1330, 1334, 1338, 1342, 1346, 1350, 1354, 1358, 1362, 1366, 1370, 1374, 1378, 1382, 1386, 1390, 1394, 1398, 1402, 1406, 1410, 1414, 1418, 1422, 1426, 1430, 1434, 1438, 1442, 1446, 1450, 1454, 1458, 1462, 1466, 1470, 1474, 1478, 1482, 1486, 1490, 1494, 1498, 1502, 1506, 1510, 1514, 1518, 1522, 1526, 1530, 1534, 1538, 1542, 1546, 1550, 1554, 1558, 1562, 1566, 1570, 1574, 1578, 1582, 1586, 1590, 1594, 1598, 1602, 1606, 1610, 1614, 1618, 1622, 1626, 1630, 1634, 1638, 1642, 1646, 1650, 1654, 1658, 1662, 1666, 1670, 1674, 1678, 1682, 1686, 1690, 1694, 1698, 1702, 1706, 1710, 1714, 1718, 1722, 1726, 1730, 1734, 1738, 1742, 1746, 1750, 1754, 1758, 1762, 1766, 1770, 1774, 1778, 1782, 1786, 1790, 1794, 1798, 1802, 1806, 1810, 1814, 1818, 1822, 1826, 1830, 1834, 1838, 1842, 1846, 1850, 1854, 1858, 1862, 1866, 1870, 1874, 1878, 1882, 1886, 1890, 1894, 1898, 1902, 1906, 1910, 1914 or 1918. The nucleobase sequence of the antisense strand may consist of a nucleobase sequence that is identical to any of SEQ ID NOs: 3, 7, 11, 15, 19, 23, 27, 31, 35, 39, 43, 47, 51, 55, 59, 63, 67, 71, 75, 79, 83, 87, 91, 95, 99, 103, 107, 111, 115, 119, 123, 127, 131, 135, 139, 143, 147, 151, 155, 159, 163, 167, 171, 175, 179, 183, 187, 191, 195, 199, 203, 207, 211, 215, 219, 223, 227, 231, 235, 239, 243, 247, 251, 255, 259, 263, 267, 271, 275, 279, 283, 287, 291, 295, 299, 303, 307, 311, 315, 319, 323, 327, 331, 335, 339, 343, 347, 351, 355, 359, 363, 367, 371, 375, 379, 383, 387, 391, 395, 399, 403, 407, 411, 415, 419, 423, 427, 431, 435, 439, 443, 447, 451, 455, 459, 463, 467, 471, 475, 479, 483, 487, 491, 495, 499, 503, 507, 511, 515, 519, 523, 527, 531, 535, 539, 543, 547, 551, 555, 559, 563, 567, 571, 575, 579, 583, 587, 591, 595, 599, 603, 607, 611, 615, 619, 623, 627, 631, 635, 639, 643, 647, 651, 655, 659, 663, 667, 671, 675, 679, 683, 687, 691, 695, 699, 703, 707, 711, 715, 719, 723, 727, 731, 735, 739, 743, 747, 751, 755, 759, 763, 767, 771, 775, 779, 783, 787, 791, 795, 799, 803, 807, 811, 815, 819, 823, 827, 831, 835, 839, 843, 847, 851, 855, 859, 863, 867, 871, 875, 879, 883, 887, 891, 895, 899, 903, 907, 911, 915, 919, 923, 927, 931, 935, 939, 943, 947, 951, 955, 959, 963, 967, 971, 975, 979, 983, 987, 991, 995, 999, 1003, 1007, 1011, 1015, 1019, 1023, 1027, 1031, 1035, 1039, 1043, 1047, 1051, 1055, 1059, 1063, 1067, 1071, 1075, 1079, 1083, 1087, 1091, 1095, 1099, 1103, 1107, 1111, 1115, 1119, 1123, 1127, 1131, 1135, 1139, 1143, 1147, 1151, 1155, 1159, 1163, 1167, 1171, 1175, 1179, 1183, 1187, 1191, 1195, 1199, 1203, 1207, 1211, 1215, 1219, 1223, 1227, 1231, 1235, 1239, 1243, 1247, 1251, 1255, 1259, 1263, 1267, 1271, 1275, 1279, 1283, 1287, 1291, 1295, 1299, 1303, 1307, 1311, 1315, 1319, 1323, 1327, 1331, 1335, 1339, 1343, 1347, 1351, 1355, 1359, 1363, 1367, 1371, 1375, 1379, 1383, 1387, 1391, 1395, 1399, 1403, 1407, 1411, 1415, 1419, 1423, 1427, 1431, 1435, 1439, 1443, 1447, 1451, 1455, 1459, 1463, 1467, 1471, 1475, 1479, 1483, 1487, 1491, 1495, 1499, 1503, 1507, 1511, 1515, 1519, 1523, 1527, 1531, 1535, 1539, 1543, 1547, 1551, 1555, 1559, 1563, 1567, 1571, 1575, 1579, 1583, 1587, 1591, 1595, 1599, 1603, 1607, 1611, 1615, 1619, 1623, 1627, 1631, 1635, 1639, 1643, 1647, 1651, 1655, 1659, 1663, 1667, 1671, 1675, 1679, 1683, 1687, 1691, 1695, 1699, 1703, 1707, 1711, 1715, 1719, 1723, 1727, 1731, 1735, 1739, 1743, 1747, 1751, 1755, 1759, 1763, 1767, 1771, 1775, 1779, 1783, 1787, 1791, 1795, 1799, 1803, 1807, 1811, 1815, 1819, 1823, 1827, 1831, 1835, 1839, 1843, 1847, 1851, 1855, 1859, 1863, 1867, 1871, 1875, 1879, 1883, 1887, 1891, 1895, 1899, 1903, 1907, 1911, 1915 or 1919. The nucleobase sequence of the antisense strand may consist of a nucleobase sequence that is identical to any of SEQ ID NOs: 34, 35, 54, 55, 58, 59, 142, 143, 158, 159, 250, 251, 262, 263, 282, 283, 286, 287, 390, 391, 398, 399, 426, 427, 470, 471, 478, 479, 494, 495, 502, 503, 522, 523, 566, 567, 574, 575, 586, 587, 606, 607, 618, 619, 626, 627, 654, 655, 666, 667, 678, 679, 694, 695, 698, 699, 722, 723, 730, 731, 742, 743, 778, 779, 802, 803, 822, 823, 830, 831, 842, 843, 846, 847, 858, 859, 862, 863, 866, 867, 870, 871, 874, 875, 878, 879, 886, 887, 906, 907, 914, 915, 946, 947, 954, 955, 970, 971, 978, 979, 1006, 1007, 1018, 1019, 1022, 1023, 1026, 1027, 1034, 1035, 1038, 1039, 1042, 1043, 1058, 1059, 1082, 1083, 1086, 1087, 1102, 1103, 1118, 1119, 1126, 1127, 1142, 1143, 1146, 1147, 1150, 1151, 1154, 1155, 1158, 1159, 1182, 1183, 1186, 1187, 1190, 1191, 1210, 1211, 1214, 1215, 1254, 1255, 1270, 1271, 1274, 1275, 1278, 1279, 1282, 1283, 1294, 1295, 1298, 1299, 1302, 1303, 1310, 1311, 1330, 1331, 1334, 1335, 1346, 1347, 1354, 1355, 1358, 1359, 1362, 1363, 1366, 1367, 1602, 1603, 1614, 1615, 1618, 1619, 1626, 1627, 1630 or 1631. The nucleobase sequence of the antisense strand may consist of a nucleobase sequence that is identical to any of SEQ ID NOs: 34, 54, 58, 142, 158, 250, 262, 282, 286, 390, 398, 426, 470, 478, 494, 502, 522, 566, 574, 586, 606, 618, 626, 654, 666, 678, 694, 698, 722, 730, 742, 778, 802, 822, 830, 842, 846, 858, 862, 866, 870, 874, 878, 886, 906, 914, 946, 954, 970, 978, 1006, 1018, 1022, 1026, 1034, 1038, 1042, 1058, 1082, 1086, 1102, 1118, 1126, 1142, 1146, 1150, 1154, 1158, 1182, 1186, 1190, 1210, 1214, 1254, 1270, 1274, 1278, 1282, 1294, 1298, 1302, 1310, 1330, 1334, 1346, 1354, 1358, 1362, 1366, 1602, 1614, 1618, 1626 or 1630. The nucleobase sequence of the antisense strand may consist of a nucleobase sequence that is identical to any of SEQ ID NOs: 35, 55, 59, 143, 159, 251, 263, 283, 287, 391, 399, 427, 471, 479, 495, 503, 523, 567, 575, 587, 607, 619, 627, 655, 667, 679, 695, 699, 723, 731, 743, 779, 803, 823, 831, 843, 847, 859, 863, 867, 871, 875, 879, 887, 907, 915, 947, 955, 971, 979, 1007, 1019, 1023, 1027, 1035, 1039, 1043, 1059, 1083, 1087, 1103, 1119, 1127, 1143, 1147, 1151, 1155, 1159, 1183, 1187, 1191, 1211, 1215, 1255, 1271, 1275, 1279, 1283, 1295, 1299, 1303, 1311, 1331, 1335, 1347, 1355, 1359, 1363, 1367, 1603, 1615, 1619, 1627 or 1631. Exemplary unmodified nucleobase sequences for sense (passenger) strands of double-stranded oligonucleotides of the invention are given in column 6 of Table 1, with the corresponding sequence identifier in column 7. The compound number is shown in column 1. The position of the left-most (5'-most) residue of the corresponding nucleobase sequence in the PSD3 transcript of SEQ ID NO: 1 which is identical to a given sense nucleobase sequence is given in column 2. The position of the right-most (3'-most) residue of the corresponding nucleobase sequence in the PSD3 transcript of SEQ ID NO: 1 which is identical to a given sense nucleobase sequence is given in column 3. Exemplary modified nucleobase sequences for sense (passenger) strands of double-stranded oligonucleotides of the invention are given in column 4 of Table 3, with the corresponding sequence identifier in column 5. The compound number is shown in column 1. Preferred exemplary unmodified nucleobase sequences for sense (passenger) strands of double-stranded oligonucleotides of the invention are given in column 6 of Table 2, with the corresponding sequence identifier in column 7. The compound number is shown in column 1. The position of the left-most (5'-most) residue of the corresponding nucleobase sequence in the PSD3 transcript of SEQ ID NO: 1 which is identical to a given sense nucleobase sequence is given in column 2. The position of the right-most (3'-most) residue of the corresponding nucleobase sequence in the PSD3 transcript of SEQ ID NO: 1 which is identical to a given sense nucleobase sequence is given in column 3. Preferred exemplary modified nucleobase sequences for sense (passenger) strands of double-stranded oligonucleotides of the invention are given in column 4 of Table 4, with the corresponding sequence identifier in column 5. The compound number is shown in column 1. The nucleobase sequence of the sense strand may comprise or consist of a nucleobase sequence that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% identical to any of SEQ ID NOs: 4, 5, 8, 9, 12, 13, 16, 17, 20, 21, 24, 25, 28, 29, 32, 33, 36, 37, 40, 41, 44, 45, 48, 49, 52, 53, 56, 57, 60, 61, 64, 65, 68, 69, 72, 73, 76, 77, 80, 81, 84, 85, 88, 89, 92, 93, 96, 97, 100, 101, 104, 105, 108, 109, 112, 113, 116, 117, 120, 121, 124, 125, 128, 129, 132, 133, 136, 137, 140, 141, 144, 145, 148, 149, 152, 153, 156, 157, 160, 161, 164, 165, 168, 169, 172, 173, 176, 177, 180, 181, 184, 185, 188, 189, 192, 193, 196, 197, 200, 201, 204, 205, 208, 209, 212, 213, 216, 217, 220, 221, 224, 225, 228, 229, 232, 233, 236, 237, 240, 241, 244, 245, 248, 249, 252, 253, 256, 257, 260, 261, 264, 265, 268, 269, 272, 273, 276, 277, 280, 281, 284, 285, 288, 289, 292, 293, 296, 297, 300, 301, 304, 305, 308, 309, 312, 313, 316, 317, 320, 321, 324, 325, 328, 329, 332, 333, 336, 337, 340, 341, 344, 345, 348, 349, 352, 353, 356, 357, 360, 361, 364, 365, 368, 369, 372, 373, 376, 377, 380, 381, 384, 385, 388, 389, 392, 393, 396, 397, 400, 401, 404, 405, 408, 409, 412, 413, 416, 417, 420, 421, 424, 425, 428, 429, 432, 433, 436, 437, 440, 441, 444, 445, 448, 449, 452, 453, 456, 457, 460, 461, 464, 465, 468, 469, 472, 473, 476, 477, 480, 481, 484, 485, 488, 489, 492, 493, 496, 497, 500, 501, 504, 505, 508, 509, 512, 513, 516, 517, 520, 521, 524, 525, 528, 529, 532, 533, 536, 537, 540, 541, 544, 545, 548, 549, 552, 553, 556, 557, 560, 561, 564, 565, 568, 569, 572, 573, 576, 577, 580, 581, 584, 585, 588, 589, 592, 593, 596, 597, 600, 601, 604, 605, 608, 609, 612, 613, 616, 617, 620, 621, 624, 625, 628, 629, 632, 633, 636, 637, 640, 641, 644, 645, 648, 649, 652, 653, 656, 657, 660, 661, 664, 665, 668, 669, 672, 673, 676, 677, 680, 681, 684, 685, 688, 689, 692, 693, 696, 697, 700, 701, 704, 705, 708, 709, 712, 713, 716, 717, 720, 721, 724, 725, 728, 729, 732, 733, 736, 737, 740, 741, 744, 745, 748, 749, 752, 753, 756, 757, 760, 761, 764, 765, 768, 769, 772, 773, 776, 777, 780, 781, 784, 785, 788, 789, 792, 793, 796, 797, 800, 801, 804, 805, 808, 809, 812, 813, 816, 817, 820, 821, 824, 825, 828, 829, 832, 833, 836, 837, 840, 841, 844, 845, 848, 849, 852, 853, 856, 857, 860, 861, 864, 865, 868, 869, 872, 873, 876, 877, 880, 881, 884, 885, 888, 889, 892, 893, 896, 897, 900, 901, 904, 905, 908, 909, 912, 913, 916, 917, 920, 921, 924, 925, 928, 929, 932, 933, 936, 937, 940, 941, 944, 945, 948, 949, 952, 953, 956, 957, 960, 961, 964, 965, 968, 969, 972, 973, 976, 977, 980, 981, 984, 985, 988, 989, 992, 993, 996, 997, 1000, 1001, 1004, 1005, 1008, 1009, 1012, 1013, 1016, 1017, 1020, 1021, 1024, 1025, 1028, 1029, 1032, 1033, 1036, 1037, 1040, 1041, 1044, 1045, 1048, 1049, 1052, 1053, 1056, 1057, 1060, 1061, 1064, 1065, 1068, 1069, 1072, 1073, 1076, 1077, 1080, 1081, 1084, 1085, 1088, 1089, 1092, 1093, 1096, 1097, 1100, 1101, 1104, 1105, 1108, 1109, 1112, 1113, 1116, 1117, 1120, 1121, 1124, 1125, 1128, 1129, 1132, 1133, 1136, 1137, 1140, 1141, 1144, 1145, 1148, 1149, 1152, 1153, 1156, 1157, 1160, 1161, 1164, 1165, 1168, 1169, 1172, 1173, 1176, 1177, 1180, 1181, 1184, 1185, 1188, 1189, 1192, 1193, 1196, 1197, 1200, 1201, 1204, 1205, 1208, 1209, 1212, 1213, 1216, 1217, 1220, 1221, 1224, 1225, 1228, 1229, 1232, 1233, 1236, 1237, 1240, 1241, 1244, 1245, 1248, 1249, 1252, 1253, 1256, 1257, 1260, 1261, 1264, 1265, 1268, 1269, 1272, 1273, 1276, 1277, 1280, 1281, 1284, 1285, 1288, 1289, 1292, 1293, 1296, 1297, 1300, 1301, 1304, 1305, 1308, 1309, 1312, 1313, 1316, 1317, 1320, 1321, 1324, 1325, 1328, 1329, 1332, 1333, 1336, 1337, 1340, 1341, 1344, 1345, 1348, 1349, 1352, 1353, 1356, 1357, 1360, 1361, 1364, 1365, 1368, 1369, 1372, 1373, 1376, 1377, 1380, 1381, 1384, 1385, 1388, 1389, 1392, 1393, 1396, 1397, 1400, 1401, 1404, 1405, 1408, 1409, 1412, 1413, 1416, 1417, 1420, 1421, 1424, 1425, 1428, 1429, 1432, 1433, 1436, 1437, 1440, 1441, 1444, 1445, 1448, 1449, 1452, 1453, 1456, 1457, 1460, 1461, 1464, 1465, 1468, 1469, 1472, 1473, 1476, 1477, 1480, 1481, 1484, 1485, 1488, 1489, 1492, 1493, 1496, 1497, 1500, 1501, 1504, 1505, 1508, 1509, 1512, 1513, 1516, 1517, 1520, 1521, 1524, 1525, 1528, 1529, 1532, 1533, 1536, 1537, 1540, 1541, 1544, 1545, 1548, 1549, 1552, 1553, 1556, 1557, 1560, 1561, 1564, 1565, 1568, 1569, 1572, 1573, 1576, 1577, 1580, 1581, 1584, 1585, 1588, 1589, 1592, 1593, 1596, 1597, 1600, 1601, 1604, 1605, 1608, 1609, 1612, 1613, 1616, 1617, 1620, 1621, 1624, 1625, 1628, 1629, 1632, 1633, 1636, 1637, 1640, 1641, 1644, 1645, 1648, 1649, 1652, 1653, 1656, 1657, 1660, 1661, 1664, 1665, 1668, 1669, 1672, 1673, 1676, 1677, 1680, 1681, 1684, 1685, 1688, 1689, 1692, 1693, 1696, 1697, 1700, 1701, 1704, 1705, 1708, 1709, 1712, 1713, 1716, 1717, 1720, 1721, 1724, 1725, 1728, 1729, 1732, 1733, 1736, 1737, 1740, 1741, 1744, 1745, 1748, 1749, 1752, 1753, 1756, 1757, 1760, 1761, 1764, 1765, 1768, 1769, 1772, 1773, 1776, 1777, 1780, 1781, 1784, 1785, 1788, 1789, 1792, 1793, 1796, 1797, 1800, 1801, 1804, 1805, 1808, 1809, 1812, 1813, 1816, 1817, 1820, 1821, 1824, 1825, 1828, 1829, 1832, 1833, 1836, 1837, 1840, 1841, 1844, 1845, 1848, 1849, 1852, 1853, 1856, 1857, 1860, 1861, 1864, 1865, 1868, 1869, 1872, 1873, 1876, 1877, 1880, 1881, 1884, 1885, 1888, 1889, 1892, 1893, 1896, 1897, 1900, 1901, 1904, 1905, 1908, 1909, 1912, 1913, 1916, 1917, 1920 or 1921. The nucleobase sequence of the sense strand may comprise or consist of a nucleobase sequence that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% identical to any of SEQ ID NOs: 4, 8, 12, 16, 20, 24, 28, 32, 36, 40, 44, 48, 52, 56, 60, 64, 68, 72, 76, 80, 84, 88, 92, 96, 100, 104, 108, 112, 116, 120, 124, 128, 132, 136, 140, 144, 148, 152, 156, 160, 164, 168, 172, 176, 180, 184, 188, 192, 196, 200, 204, 208, 212, 216, 220, 224, 228, 232, 236, 240, 244, 248, 252, 256, 260, 264, 268, 272, 276, 280, 284, 288, 292, 296, 300, 304, 308, 312, 316, 320, 324, 328, 332, 336, 340, 344, 348, 352, 356, 360, 364, 368, 372, 376, 380, 384, 388, 392, 396, 400, 404, 408, 412, 416, 420, 424, 428, 432, 436, 440, 444, 448, 452, 456, 460, 464, 468, 472, 476, 480, 484, 488, 492, 496, 500, 504, 508, 512, 516, 520, 524, 528, 532, 536, 540, 544, 548, 552, 556, 560, 564, 568, 572, 576, 580, 584, 588, 592, 596, 600, 604, 608, 612, 616, 620, 624, 628, 632, 636, 640, 644, 648, 652, 656, 660, 664, 668, 672, 676, 680, 684, 688, 692, 696, 700, 704, 708, 712, 716, 720, 724, 728, 732, 736, 740, 744, 748, 752, 756, 760, 764, 768, 772, 776, 780, 784, 788, 792, 796, 800, 804, 808, 812, 816, 820, 824, 828, 832, 836, 840, 844, 848, 852, 856, 860, 864, 868, 872, 876, 880, 884, 888, 892, 896, 900, 904, 908, 912, 916, 920, 924, 928, 932, 936, 940, 944, 948, 952, 956, 960, 964, 968, 972, 976, 980, 984, 988, 992, 996, 1000, 1004, 1008, 1012, 1016, 1020, 1024, 1028, 1032, 1036, 1040, 1044, 1048, 1052, 1056, 1060, 1064, 1068, 1072, 1076, 1080, 1084, 1088, 1092, 1096, 1100, 1104, 1108, 1112, 1116, 1120, 1124, 1128, 1132, 1136, 1140, 1144, 1148, 1152, 1156, 1160, 1164, 1168, 1172, 1176, 1180, 1184, 1188, 1192, 1196, 1200, 1204, 1208, 1212, 1216, 1220, 1224, 1228, 1232, 1236, 1240, 1244, 1248, 1252, 1256, 1260, 1264, 1268, 1272, 1276, 1280, 1284, 1288, 1292, 1296, 1300, 1304, 1308, 1312, 1316, 1320, 1324, 1328, 1332, 1336, 1340, 1344, 1348, 1352, 1356, 1360, 1364, 1368, 1372, 1376, 1380, 1384, 1388, 1392, 1396, 1400, 1404, 1408, 1412, 1416, 1420, 1424, 1428, 1432, 1436, 1440, 1444, 1448, 1452, 1456, 1460, 1464, 1468, 1472, 1476, 1480, 1484, 1488, 1492, 1496, 1500, 1504, 1508, 1512, 1516, 1520, 1524, 1528, 1532, 1536, 1540, 1544, 1548, 1552, 1556, 1560, 1564, 1568, 1572, 1576, 1580, 1584, 1588, 1592, 1596, 1600, 1604, 1608, 1612, 1616, 1620, 1624, 1628, 1632, 1636, 1640, 1644, 1648, 1652, 1656, 1660, 1664, 1668, 1672, 1676, 1680, 1684, 1688, 1692, 1696, 1700, 1704, 1708, 1712, 1716, 1720, 1724, 1728, 1732, 1736, 1740, 1744, 1748, 1752, 1756, 1760, 1764, 1768, 1772, 1776, 1780, 1784, 1788, 1792, 1796, 1800, 1804, 1808, 1812, 1816, 1820, 1824, 1828, 1832, 1836, 1840, 1844, 1848, 1852, 1856, 1860, 1864, 1868, 1872, 1876, 1880, 1884, 1888, 1892, 1896, 1900, 1904, 1908, 1912, 1916 or 1920. The nucleobase sequence of the sense strand may comprise or consist of a nucleobase sequence that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% identical to any of SEQ ID NOs: 5, 9, 13, 17, 21, 25, 29, 33, 37, 41, 45, 49, 53, 57, 61, 65, 69, 73, 77, 81, 85, 89, 93, 97, 101, 105, 109, 113, 117, 121, 125, 129, 133, 137, 141, 145, 149, 153, 157, 161, 165, 169, 173, 177, 181, 185, 189, 193, 197, 201, 205, 209, 213, 217, 221, 225, 229, 233, 237, 241, 245, 249, 253, 257, 261, 265, 269, 273, 277, 281, 285, 289, 293, 297, 301, 305, 309, 313, 317, 321, 325, 329, 333, 337, 341, 345, 349, 353, 357, 361, 365, 369, 373, 377, 381, 385, 389, 393, 397, 401, 405, 409, 413, 417, 421, 425, 429, 433, 437, 441, 445, 449, 453, 457, 461, 465, 469, 473, 477, 481, 485, 489, 493, 497, 501, 505, 509, 513, 517, 521, 525, 529, 533, 537, 541, 545, 549, 553, 557, 561, 565, 569, 573, 577, 581, 585, 589, 593, 597, 601, 605, 609, 613, 617, 621, 625, 629, 633, 637, 641, 645, 649, 653, 657, 661, 665, 669, 673, 677, 681, 685, 689, 693, 697, 701, 705, 709, 713, 717, 721, 725, 729, 733, 737, 741, 745, 749, 753, 757, 761, 765, 769, 773, 777, 781, 785, 789, 793, 797, 801, 805, 809, 813, 817, 821, 825, 829, 833, 837, 841, 845, 849, 853, 857, 861, 865, 869, 873, 877, 881, 885, 889, 893, 897, 901, 905, 909, 913, 917, 921, 925, 929, 933, 937, 941, 945, 949, 953, 957, 961, 965, 969, 973, 977, 981, 985, 989, 993, 997, 1001, 1005, 1009, 1013, 1017, 1021, 1025, 1029, 1033, 1037, 1041, 1045, 1049, 1053, 1057, 1061, 1065, 1069, 1073, 1077, 1081, 1085, 1089, 1093, 1097, 1101, 1105, 1109, 1113, 1117, 1121, 1125, 1129, 1133, 1137, 1141, 1145, 1149, 1153, 1157, 1161, 1165, 1169, 1173, 1177, 1181, 1185, 1189, 1193, 1197, 1201, 1205, 1209, 1213, 1217, 1221, 1225, 1229, 1233, 1237, 1241, 1245, 1249, 1253, 1257, 1261, 1265, 1269, 1273, 1277, 1281, 1285, 1289, 1293, 1297, 1301, 1305, 1309, 1313, 1317, 1321, 1325, 1329, 1333, 1337, 1341, 1345, 1349, 1353, 1357, 1361, 1365, 1369, 1373, 1377, 1381, 1385, 1389, 1393, 1397, 1401, 1405, 1409, 1413, 1417, 1421, 1425, 1429, 1433, 1437, 1441, 1445, 1449, 1453, 1457, 1461, 1465, 1469, 1473, 1477, 1481, 1485, 1489, 1493, 1497, 1501, 1505, 1509, 1513, 1517, 1521, 1525, 1529, 1533, 1537, 1541, 1545, 1549, 1553, 1557, 1561, 1565, 1569, 1573, 1577, 1581, 1585, 1589, 1593, 1597, 1601, 1605, 1609, 1613, 1617, 1621, 1625, 1629, 1633, 1637, 1641, 1645, 1649, 1653, 1657, 1661, 1665, 1669, 1673, 1677, 1681, 1685, 1689, 1693, 1697, 1701, 1705, 1709, 1713, 1717, 1721, 1725, 1729, 1733, 1737, 1741, 1745, 1749, 1753, 1757, 1761, 1765, 1769, 1773, 1777, 1781, 1785, 1789, 1793, 1797, 1801, 1805, 1809, 1813, 1817, 1821, 1825, 1829, 1833, 1837, 1841, 1845, 1849, 1853, 1857, 1861, 1865, 1869, 1873, 1877, 1881, 1885, 1889, 1893, 1897, 1901, 1905, 1909, 1913, 1917 or 1921. The nucleobase sequence of the sense strand may comprise or consist of a nucleobase sequence that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% identical to any of SEQ ID NOs: 36, 37, 56, 57, 60, 61, 144, 145, 160, 161, 252, 253, 264, 265, 284, 285, 288, 289, 392, 393, 400, 401, 428, 429, 472, 473, 480, 481, 496, 497, 504, 505, 524, 525, 568, 569, 576, 577, 588, 589, 608, 609, 620, 621, 628, 629, 656, 657, 668, 669, 680, 681, 696, 697, 700, 701, 724, 725, 732, 733, 744, 745, 780, 781, 804, 805, 824, 825, 832, 833, 844, 845, 848, 849, 860, 861, 864, 865, 868, 869, 872, 873, 876, 877, 880, 881, 888, 889, 908, 909, 916, 917, 948, 949, 956, 957, 972, 973, 980, 981, 1008, 1009, 1020, 1021, 1024, 1025, 1028, 1029, 1036, 1037, 1040, 1041, 1044, 1045, 1060, 1061, 1084, 1085, 1088, 1089, 1104, 1105, 1120, 1121, 1128, 1129, 1144, 1145, 1148, 1149, 1152, 1153, 1156, 1157, 1160, 1161, 1184, 1185, 1188, 1189, 1192, 1193, 1212, 1213, 1216, 1217, 1256, 1257, 1272, 1273, 1276, 1277, 1280, 1281, 1284, 1285, 1296, 1297, 1300, 1301, 1304, 1305, 1312, 1313, 1332, 1333, 1336, 1337, 1348, 1349, 1356, 1357, 1360, 1361, 1364, 1365, 1368, 1369, 1604, 1605, 1616, 1617, 1620, 1621, 1628, 1629, 1632 or 1633. The nucleobase sequence of the sense strand may comprise or consist of a nucleobase sequence that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% identical to any of SEQ ID NOs: 36, 56, 60, 144, 160, 252, 264, 284, 288, 392, 400, 428, 472, 480, 496, 504, 524, 568, 576, 588, 608, 620, 628, 656, 668, 680, 696, 700, 724, 732, 744, 780, 804, 824, 832, 844, 848, 860, 864, 868, 872, 876, 880, 888, 908, 916, 948, 956, 972, 980, 1008, 1020, 1024, 1028, 1036, 1040, 1044, 1060, 1084, 1088, 1104, 1120, 1128, 1144, 1148, 1152, 1156, 1160, 1184, 1188, 1192, 1212, 1216, 1256, 1272, 1276, 1280, 1284, 1296, 1300, 1304, 1312, 1332, 1336, 1348, 1356, 1360, 1364, 1368, 1604, 1616, 1620, 1628 or 1632. The nucleobase sequence of the sense strand may comprise or consist of a nucleobase sequence that is at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, at least 99.9%, or more, up to 100% identical to any of SEQ ID NOs: 37, 57, 61, 145, 161, 253, 265, 285, 289, 393, 401, 429, 473, 481, 497, 505, 525, 569, 577, 589, 609, 621, 629, 657, 669, 681, 697, 701, 725, 733, 745, 781, 805, 825, 833, 845, 849, 861, 865, 869, 873, 877, 881, 889, 909, 917, 949, 957, 973, 981, 1009, 1021, 1025, 1029, 1037, 1041, 1045, 1061, 1085, 1089, 1105, 1121, 1129, 1145, 1149, 1153, 1157, 1161, 1185, 1189, 1193, 1213, 1217, 1257, 1273, 1277, 1281, 1285, 1297, 1301, 1305, 1313, 1333, 1337, 1349, 1357, 1361, 1365, 1369, 1605, 1617, 1621, 1629 or 1633. The nucleobase sequence of the sense strand may comprise or consist of a nucleobase sequence that is at least 90% identical to any of SEQ ID NOs: 4, 5, 8, 9, 12, 13, 16, 17, 20, 21, 24, 25, 28, 29, 32, 33, 36, 37, 40, 41, 44, 45, 48, 49, 52, 53, 56, 57, 60, 61, 64, 65, 68, 69, 72, 73, 76, 77, 80, 81, 84, 85, 88, 89, 92, 93, 96, 97, 100, 101, 104, 105, 108, 109, 112, 113, 116, 117, 120, 121, 124, 125, 128, 129, 132, 133, 136, 137, 140, 141, 144, 145, 148, 149, 152, 153, 156, 157, 160, 161, 164, 165, 168, 169, 172, 173, 176, 177, 180, 181, 184, 185, 188, 189, 192, 193, 196, 197, 200, 201, 204, 205, 208, 209, 212, 213, 216, 217, 220, 221, 224, 225, 228, 229, 232, 233, 236, 237, 240, 241, 244, 245, 248, 249, 252, 253, 256, 257, 260, 261, 264, 265, 268, 269, 272, 273, 276, 277, 280, 281, 284, 285, 288, 289, 292, 293, 296, 297, 300, 301, 304, 305, 308, 309, 312, 313, 316, 317, 320, 321, 324, 325, 328, 329, 332, 333, 336, 337, 340, 341, 344, 345, 348, 349, 352, 353, 356, 357, 360, 361, 364, 365, 368, 369, 372, 373, 376, 377, 380, 381, 384, 385, 388, 389, 392, 393, 396, 397, 400, 401, 404, 405, 408, 409, 412, 413, 416, 417, 420, 421, 424, 425, 428, 429, 432, 433, 436, 437, 440, 441, 444, 445, 448, 449, 452, 453, 456, 457, 460, 461, 464, 465, 468, 469, 472, 473, 476, 477, 480, 481, 484, 485, 488, 489, 492, 493, 496, 497, 500, 501, 504, 505, 508, 509, 512, 513, 516, 517, 520, 521, 524, 525, 528, 529, 532, 533, 536, 537, 540, 541, 544, 545, 548, 549, 552, 553, 556, 557, 560, 561, 564, 565, 568, 569, 572, 573, 576, 577, 580, 581, 584, 585, 588, 589, 592, 593, 596, 597, 600, 601, 604, 605, 608, 609, 612, 613, 616, 617, 620, 621, 624, 625, 628, 629, 632, 633, 636, 637, 640, 641, 644, 645, 648, 649, 652, 653, 656, 657, 660, 661, 664, 665, 668, 669, 672, 673, 676, 677, 680, 681, 684, 685, 688, 689, 692, 693, 696, 697, 700, 701, 704, 705, 708, 709, 712, 713, 716, 717, 720, 721, 724, 725, 728, 729, 732, 733, 736, 737, 740, 741, 744, 745, 748, 749, 752, 753, 756, 757, 760, 761, 764, 765, 768, 769, 772, 773, 776, 777, 780, 781, 784, 785, 788, 789, 792, 793, 796, 797, 800, 801, 804, 805, 808, 809, 812, 813, 816, 817, 820, 821, 824, 825, 828, 829, 832, 833, 836, 837, 840, 841, 844, 845, 848, 849, 852, 853, 856, 857, 860, 861, 864, 865, 868, 869, 872, 873, 876, 877, 880, 881, 884, 885, 888, 889, 892, 893, 896, 897, 900, 901, 904, 905, 908, 909, 912, 913, 916, 917, 920, 921, 924, 925, 928, 929, 932, 933, 936, 937, 940, 941, 944, 945, 948, 949, 952, 953, 956, 957, 960, 961, 964, 965, 968, 969, 972, 973, 976, 977, 980, 981, 984, 985, 988, 989, 992, 993, 996, 997, 1000, 1001, 1004, 1005, 1008, 1009, 1012, 1013, 1016, 1017, 1020, 1021, 1024, 1025, 1028, 1029, 1032, 1033, 1036, 1037, 1040, 1041, 1044, 1045, 1048, 1049, 1052, 1053, 1056, 1057, 1060, 1061, 1064, 1065, 1068, 1069, 1072, 1073, 1076, 1077, 1080, 1081, 1084, 1085, 1088, 1089, 1092, 1093, 1096, 1097, 1100, 1101, 1104, 1105, 1108, 1109, 1112, 1113, 1116, 1117, 1120, 1121, 1124, 1125, 1128, 1129, 1132, 1133, 1136, 1137, 1140, 1141, 1144, 1145, 1148, 1149, 1152, 1153, 1156, 1157, 1160, 1161, 1164, 1165, 1168, 1169, 1172, 1173, 1176, 1177, 1180, 1181, 1184, 1185, 1188, 1189, 1192, 1193, 1196, 1197, 1200, 1201, 1204, 1205, 1208, 1209, 1212, 1213, 1216, 1217, 1220, 1221, 1224, 1225, 1228, 1229, 1232, 1233, 1236, 1237, 1240, 1241, 1244, 1245, 1248, 1249, 1252, 1253, 1256, 1257, 1260, 1261, 1264, 1265, 1268, 1269, 1272, 1273, 1276, 1277, 1280, 1281, 1284, 1285, 1288, 1289, 1292, 1293, 1296, 1297, 1300, 1301, 1304, 1305, 1308, 1309, 1312, 1313, 1316, 1317, 1320, 1321, 1324, 1325, 1328, 1329, 1332, 1333, 1336, 1337, 1340, 1341, 1344, 1345, 1348, 1349, 1352, 1353, 1356, 1357, 1360, 1361, 1364, 1365, 1368, 1369, 1372, 1373, 1376, 1377, 1380, 1381, 1384, 1385, 1388, 1389, 1392, 1393, 1396, 1397, 1400, 1401, 1404, 1405, 1408, 1409, 1412, 1413, 1416, 1417, 1420, 1421, 1424, 1425, 1428, 1429, 1432, 1433, 1436, 1437, 1440, 1441, 1444, 1445, 1448, 1449, 1452, 1453, 1456, 1457, 1460, 1461, 1464, 1465, 1468, 1469, 1472, 1473, 1476, 1477, 1480, 1481, 1484, 1485, 1488, 1489, 1492, 1493, 1496, 1497, 1500, 1501, 1504, 1505, 1508, 1509, 1512, 1513, 1516, 1517, 1520, 1521, 1524, 1525, 1528, 1529, 1532, 1533, 1536, 1537, 1540, 1541, 1544, 1545, 1548, 1549, 1552, 1553, 1556, 1557, 1560, 1561, 1564, 1565, 1568, 1569, 1572, 1573, 1576, 1577, 1580, 1581, 1584, 1585, 1588, 1589, 1592, 1593, 1596, 1597, 1600, 1601, 1604, 1605, 1608, 1609, 1612, 1613, 1616, 1617, 1620, 1621, 1624, 1625, 1628, 1629, 1632, 1633, 1636, 1637, 1640, 1641, 1644, 1645, 1648, 1649, 1652, 1653, 1656, 1657, 1660, 1661, 1664, 1665, 1668, 1669, 1672, 1673, 1676, 1677, 1680, 1681, 1684, 1685, 1688, 1689, 1692, 1693, 1696, 1697, 1700, 1701, 1704, 1705, 1708, 1709, 1712, 1713, 1716, 1717, 1720, 1721, 1724, 1725, 1728, 1729, 1732, 1733, 1736, 1737, 1740, 1741, 1744, 1745, 1748, 1749, 1752, 1753, 1756, 1757, 1760, 1761, 1764, 1765, 1768, 1769, 1772, 1773, 1776, 1777, 1780, 1781, 1784, 1785, 1788, 1789, 1792, 1793, 1796, 1797, 1800, 1801, 1804, 1805, 1808, 1809, 1812, 1813, 1816, 1817, 1820, 1821, 1824, 1825, 1828, 1829, 1832, 1833, 1836, 1837, 1840, 1841, 1844, 1845, 1848, 1849, 1852, 1853, 1856, 1857, 1860, 1861, 1864, 1865, 1868, 1869, 1872, 1873, 1876, 1877, 1880, 1881, 1884, 1885, 1888, 1889, 1892, 1893, 1896, 1897, 1900, 1901, 1904, 1905, 1908, 1909, 1912, 1913, 1916, 1917, 1920 or 1921. The nucleobase sequence of the sense strand may comprise or consist of a nucleobase sequence that is at least 90% identical to any of SEQ ID NOs: 4, 8, 12, 16, 20, 24, 28, 32, 36, 40, 44, 48, 52, 56, 60, 64, 68, 72, 76, 80, 84, 88, 92, 96, 100, 104, 108, 112, 116, 120, 124, 128, 132, 136, 140, 144, 148, 152, 156, 160, 164, 168, 172, 176, 180, 184, 188, 192, 196, 200, 204, 208, 212, 216, 220, 224, 228, 232, 236, 240, 244, 248, 252, 256, 260, 264, 268, 272, 276, 280, 284, 288, 292, 296, 300, 304, 308, 312, 316, 320, 324, 328, 332, 336, 340, 344, 348, 352, 356, 360, 364, 368, 372, 376, 380, 384, 388, 392, 396, 400, 404, 408, 412, 416, 420, 424, 428, 432, 436, 440, 444, 448, 452, 456, 460, 464, 468, 472, 476, 480, 484, 488, 492, 496, 500, 504, 508, 512, 516, 520, 524, 528, 532, 536, 540, 544, 548, 552, 556, 560, 564, 568, 572, 576, 580, 584, 588, 592, 596, 600, 604, 608, 612, 616, 620, 624, 628, 632, 636, 640, 644, 648, 652, 656, 660, 664, 668, 672, 676, 680, 684, 688, 692, 696, 700, 704, 708, 712, 716, 720, 724, 728, 732, 736, 740, 744, 748, 752, 756, 760, 764, 768, 772, 776, 780, 784, 788, 792, 796, 800, 804, 808, 812, 816, 820, 824, 828, 832, 836, 840, 844, 848, 852, 856, 860, 864, 868, 872, 876, 880, 884, 888, 892, 896, 900, 904, 908, 912, 916, 920, 924, 928, 932, 936, 940, 944, 948, 952, 956, 960, 964, 968, 972, 976, 980, 984, 988, 992, 996, 1000, 1004, 1008, 1012, 1016, 1020, 1024, 1028, 1032, 1036, 1040, 1044, 1048, 1052, 1056, 1060, 1064, 1068, 1072, 1076, 1080, 1084, 1088, 1092, 1096, 1100, 1104, 1108, 1112, 1116, 1120, 1124, 1128, 1132, 1136, 1140, 1144, 1148, 1152, 1156, 1160, 1164, 1168, 1172, 1176, 1180, 1184, 1188, 1192, 1196, 1200, 1204, 1208, 1212, 1216, 1220, 1224, 1228, 1232, 1236, 1240, 1244, 1248, 1252, 1256, 1260, 1264, 1268, 1272, 1276, 1280, 1284, 1288, 1292, 1296, 1300, 1304, 1308, 1312, 1316, 1320, 1324, 1328, 1332, 1336, 1340, 1344, 1348, 1352, 1356, 1360, 1364, 1368, 1372, 1376, 1380, 1384, 1388, 1392, 1396, 1400, 1404, 1408, 1412, 1416, 1420, 1424, 1428, 1432, 1436, 1440, 1444, 1448, 1452, 1456, 1460, 1464, 1468, 1472, 1476, 1480, 1484, 1488, 1492, 1496, 1500, 1504, 1508, 1512, 1516, 1520, 1524, 1528, 1532, 1536, 1540, 1544, 1548, 1552, 1556, 1560, 1564, 1568, 1572, 1576, 1580, 1584, 1588, 1592, 1596, 1600, 1604, 1608, 1612, 1616, 1620, 1624, 1628, 1632, 1636, 1640, 1644, 1648, 1652, 1656, 1660, 1664, 1668, 1672, 1676, 1680, 1684, 1688, 1692, 1696, 1700, 1704, 1708, 1712, 1716, 1720, 1724, 1728, 1732, 1736, 1740, 1744, 1748, 1752, 1756, 1760, 1764, 1768, 1772, 1776, 1780, 1784, 1788, 1792, 1796, 1800, 1804, 1808, 1812, 1816, 1820, 1824, 1828, 1832, 1836, 1840, 1844, 1848, 1852, 1856, 1860, 1864, 1868, 1872, 1876, 1880, 1884, 1888, 1892, 1896, 1900, 1904, 1908, 1912, 1916 or 1920. The nucleobase sequence of the sense strand may comprise or consist of a nucleobase sequence that is at least 90% identical to any of SEQ ID NOs: 5, 9, 13, 17, 21, 25, 29, 33, 37, 41, 45, 49, 53, 57, 61, 65, 69, 73, 77, 81, 85, 89, 93, 97, 101, 105, 109, 113, 117, 121, 125, 129, 133, 137, 141, 145, 149, 153, 157, 161, 165, 169, 173, 177, 181, 185, 189, 193, 197, 201, 205, 209, 213, 217, 221, 225, 229, 233, 237, 241, 245, 249, 253, 257, 261, 265, 269, 273, 277, 281, 285, 289, 293, 297, 301, 305, 309, 313, 317, 321, 325, 329, 333, 337, 341, 345, 349, 353, 357, 361, 365, 369, 373, 377, 381, 385, 389, 393, 397, 401, 405, 409, 413, 417, 421, 425, 429, 433, 437, 441, 445, 449, 453, 457, 461, 465, 469, 473, 477, 481, 485, 489, 493, 497, 501, 505, 509, 513, 517, 521, 525, 529, 533, 537, 541, 545, 549, 553, 557, 561, 565, 569, 573, 577, 581, 585, 589, 593, 597, 601, 605, 609, 613, 617, 621, 625, 629, 633, 637, 641, 645, 649, 653, 657, 661, 665, 669, 673, 677, 681, 685, 689, 693, 697, 701, 705, 709, 713, 717, 721, 725, 729, 733, 737, 741, 745, 749, 753, 757, 761, 765, 769, 773, 777, 781, 785, 789, 793, 797, 801, 805, 809, 813, 817, 821, 825, 829, 833, 837, 841, 845, 849, 853, 857, 861, 865, 869, 873, 877, 881, 885, 889, 893, 897, 901, 905, 909, 913, 917, 921, 925, 929, 933, 937, 941, 945, 949, 953, 957, 961, 965, 969, 973, 977, 981, 985, 989, 993, 997, 1001, 1005, 1009, 1013, 1017, 1021, 1025, 1029, 1033, 1037, 1041, 1045, 1049, 1053, 1057, 1061, 1065, 1069, 1073, 1077, 1081, 1085, 1089, 1093, 1097, 1101, 1105, 1109, 1113, 1117, 1121, 1125, 1129, 1133, 1137, 1141, 1145, 1149, 1153, 1157, 1161, 1165, 1169, 1173, 1177, 1181, 1185, 1189, 1193, 1197, 1201, 1205, 1209, 1213, 1217, 1221, 1225, 1229, 1233, 1237, 1241, 1245, 1249, 1253, 1257, 1261, 1265, 1269, 1273, 1277, 1281, 1285, 1289, 1293, 1297, 1301, 1305, 1309, 1313, 1317, 1321, 1325, 1329, 1333, 1337, 1341, 1345, 1349, 1353, 1357, 1361, 1365, 1369, 1373, 1377, 1381, 1385, 1389, 1393, 1397, 1401, 1405, 1409, 1413, 1417, 1421, 1425, 1429, 1433, 1437, 1441, 1445, 1449, 1453, 1457, 1461, 1465, 1469, 1473, 1477, 1481, 1485, 1489, 1493, 1497, 1501, 1505, 1509, 1513, 1517, 1521, 1525, 1529, 1533, 1537, 1541, 1545, 1549, 1553, 1557, 1561, 1565, 1569, 1573, 1577, 1581, 1585, 1589, 1593, 1597, 1601, 1605, 1609, 1613, 1617, 1621, 1625, 1629, 1633, 1637, 1641, 1645, 1649, 1653, 1657, 1661, 1665, 1669, 1673, 1677, 1681, 1685, 1689, 1693, 1697, 1701, 1705, 1709, 1713, 1717, 1721, 1725, 1729, 1733, 1737, 1741, 1745, 1749, 1753, 1757, 1761, 1765, 1769, 1773, 1777, 1781, 1785, 1789, 1793, 1797, 1801, 1805, 1809, 1813, 1817, 1821, 1825, 1829, 1833, 1837, 1841, 1845, 1849, 1853, 1857, 1861, 1865, 1869, 1873, 1877, 1881, 1885, 1889, 1893, 1897, 1901, 1905, 1909, 1913, 1917 or 1921. The nucleobase sequence of the sense strand may comprise or consist of a nucleobase sequence that is at least 90% identical to any of SEQ ID NOs: 36, 37, 56, 57, 60, 61, 144, 145, 160, 161, 252, 253, 264, 265, 284, 285, 288, 289, 392, 393, 400, 401, 428, 429, 472, 473, 480, 481, 496, 497, 504, 505, 524, 525, 568, 569, 576, 577, 588, 589, 608, 609, 620, 621, 628, 629, 656, 657, 668, 669, 680, 681, 696, 697, 700, 701, 724, 725, 732, 733, 744, 745, 780, 781, 804, 805, 824, 825, 832, 833, 844, 845, 848, 849, 860, 861, 864, 865, 868, 869, 872, 873, 876, 877, 880, 881, 888, 889, 908, 909, 916, 917, 948, 949, 956, 957, 972, 973, 980, 981, 1008, 1009, 1020, 1021, 1024, 1025, 1028, 1029, 1036, 1037, 1040, 1041, 1044, 1045, 1060, 1061, 1084, 1085, 1088, 1089, 1104, 1105, 1120, 1121, 1128, 1129, 1144, 1145, 1148, 1149, 1152, 1153, 1156, 1157, 1160, 1161, 1184, 1185, 1188, 1189, 1192, 1193, 1212, 1213, 1216, 1217, 1256, 1257, 1272, 1273, 1276, 1277, 1280, 1281, 1284, 1285, 1296, 1297, 1300, 1301, 1304, 1305, 1312, 1313, 1332, 1333, 1336, 1337, 1348, 1349, 1356, 1357, 1360, 1361, 1364, 1365, 1368, 1369, 1604, 1605, 1616, 1617, 1620, 1621, 1628, 1629, 1632 or 1633. The nucleobase sequence of the sense strand may comprise or consist of a nucleobase sequence that is at least 90% identical to any of SEQ ID NOs: 36, 56, 60, 144, 160, 252, 264, 284, 288, 392, 400, 428, 472, 480, 496, 504, 524, 568, 576, 588, 608, 620, 628, 656, 668, 680, 696, 700, 724, 732, 744, 780, 804, 824, 832, 844, 848, 860, 864, 868, 872, 876, 880, 888, 908, 916, 948, 956, 972, 980, 1008, 1020, 1024, 1028, 1036, 1040, 1044, 1060, 1084, 1088, 1104, 1120, 1128, 1144, 1148, 1152, 1156, 1160, 1184, 1188, 1192, 1212, 1216, 1256, 1272, 1276, 1280, 1284, 1296, 1300, 1304, 1312, 1332, 1336, 1348, 1356, 1360, 1364, 1368, 1604, 1616, 1620, 1628 or 1632. The nucleobase sequence of the sense strand may comprise or consist of a nucleobase sequence that is at least 90% identical to any of SEQ ID NOs: 37, 57, 61, 145, 161, 253, 265, 285, 289, 393, 401, 429, 473, 481, 497, 505, 525, 569, 577, 589, 609, 621, 629, 657, 669, 681, 697, 701, 725, 733, 745, 781, 805, 825, 833, 845, 849, 861, 865, 869, 873, 877, 881, 889, 909, 917, 949, 957, 973, 981, 1009, 1021, 1025, 1029, 1037, 1041, 1045, 1061, 1085, 1089, 1105, 1121, 1129, 1145, 1149, 1153, 1157, 1161, 1185, 1189, 1193, 1213, 1217, 1257, 1273, 1277, 1281, 1285, 1297, 1301, 1305, 1313, 1333, 1337, 1349, 1357, 1361, 1365, 1369, 1605, 1617, 1621, 1629 or 1633. The nucleobase sequence of the sense strand may comprise or consist of a nucleobase sequence that is at least 95% identical to any of SEQ ID NOs: 4, 5, 8, 9, 12, 13, 16, 17, 20, 21, 24, 25, 28, 29, 32, 33, 36, 37, 40, 41, 44, 45, 48, 49, 52, 53, 56, 57, 60, 61, 64, 65, 68, 69, 72, 73, 76, 77, 80, 81, 84, 85, 88, 89, 92, 93, 96, 97, 100, 101, 104, 105, 108, 109, 112, 113, 116, 117, 120, 121, 124, 125, 128, 129, 132, 133, 136, 137, 140, 141, 144, 145, 148, 149, 152, 153, 156, 157, 160, 161, 164, 165, 168, 169, 172, 173, 176, 177, 180, 181, 184, 185, 188, 189, 192, 193, 196, 197, 200, 201, 204, 205, 208, 209, 212, 213, 216, 217, 220, 221, 224, 225, 228, 229, 232, 233, 236, 237, 240, 241, 244, 245, 248, 249, 252, 253, 256, 257, 260, 261, 264, 265, 268, 269, 272, 273, 276, 277, 280, 281, 284, 285, 288, 289, 292, 293, 296, 297, 300, 301, 304, 305, 308, 309, 312, 313, 316, 317, 320, 321, 324, 325, 328, 329, 332, 333, 336, 337, 340, 341, 344, 345, 348, 349, 352, 353, 356, 357, 360, 361, 364, 365, 368, 369, 372, 373, 376, 377, 380, 381, 384, 385, 388, 389, 392, 393, 396, 397, 400, 401, 404, 405, 408, 409, 412, 413, 416, 417, 420, 421, 424, 425, 428, 429, 432, 433, 436, 437, 440, 441, 444, 445, 448, 449, 452, 453, 456, 457, 460, 461, 464, 465, 468, 469, 472, 473, 476, 477, 480, 481, 484, 485, 488, 489, 492, 493, 496, 497, 500, 501, 504, 505, 508, 509, 512, 513, 516, 517, 520, 521, 524, 525, 528, 529, 532, 533, 536, 537, 540, 541, 544, 545, 548, 549, 552, 553, 556, 557, 560, 561, 564, 565, 568, 569, 572, 573, 576, 577, 580, 581, 584, 585, 588, 589, 592, 593, 596, 597, 600, 601, 604, 605, 608, 609, 612, 613, 616, 617, 620, 621, 624, 625, 628, 629, 632, 633, 636, 637, 640, 641, 644, 645, 648, 649, 652, 653, 656, 657, 660, 661, 664, 665, 668, 669, 672, 673, 676, 677, 680, 681, 684, 685, 688, 689, 692, 693, 696, 697, 700, 701, 704, 705, 708, 709, 712, 713, 716, 717, 720, 721, 724, 725, 728, 729, 732, 733, 736, 737, 740, 741, 744, 745, 748, 749, 752, 753, 756, 757, 760, 761, 764, 765, 768, 769, 772, 773, 776, 777, 780, 781, 784, 785, 788, 789, 792, 793, 796, 797, 800, 801, 804, 805, 808, 809, 812, 813, 816, 817, 820, 821, 824, 825, 828, 829, 832, 833, 836, 837, 840, 841, 844, 845, 848, 849, 852, 853, 856, 857, 860, 861, 864, 865, 868, 869, 872, 873, 876, 877, 880, 881, 884, 885, 888, 889, 892, 893, 896, 897, 900, 901, 904, 905, 908, 909, 912, 913, 916, 917, 920, 921, 924, 925, 928, 929, 932, 933, 936, 937, 940, 941, 944, 945, 948, 949, 952, 953, 956, 957, 960, 961, 964, 965, 968, 969, 972, 973, 976, 977, 980, 981, 984, 985, 988, 989, 992, 993, 996, 997, 1000, 1001, 1004, 1005, 1008, 1009, 1012, 1013, 1016, 1017, 1020, 1021, 1024, 1025, 1028, 1029, 1032, 1033, 1036, 1037, 1040, 1041, 1044, 1045, 1048, 1049, 1052, 1053, 1056, 1057, 1060, 1061, 1064, 1065, 1068, 1069, 1072, 1073, 1076, 1077, 1080, 1081, 1084, 1085, 1088, 1089, 1092, 1093, 1096, 1097, 1100, 1101, 1104, 1105, 1108, 1109, 1112, 1113, 1116, 1117, 1120, 1121, 1124, 1125, 1128, 1129, 1132, 1133, 1136, 1137, 1140, 1141, 1144, 1145, 1148, 1149, 1152, 1153, 1156, 1157, 1160, 1161, 1164, 1165, 1168, 1169, 1172, 1173, 1176, 1177, 1180, 1181, 1184, 1185, 1188, 1189, 1192, 1193, 1196, 1197, 1200, 1201, 1204, 1205, 1208, 1209, 1212, 1213, 1216, 1217, 1220, 1221, 1224, 1225, 1228, 1229, 1232, 1233, 1236, 1237, 1240, 1241, 1244, 1245, 1248, 1249, 1252, 1253, 1256, 1257, 1260, 1261, 1264, 1265, 1268, 1269, 1272, 1273, 1276, 1277, 1280, 1281, 1284, 1285, 1288, 1289, 1292, 1293, 1296, 1297, 1300, 1301, 1304, 1305, 1308, 1309, 1312, 1313, 1316, 1317, 1320, 1321, 1324, 1325, 1328, 1329, 1332, 1333, 1336, 1337, 1340, 1341, 1344, 1345, 1348, 1349, 1352, 1353, 1356, 1357, 1360, 1361, 1364, 1365, 1368, 1369, 1372, 1373, 1376, 1377, 1380, 1381, 1384, 1385, 1388, 1389, 1392, 1393, 1396, 1397, 1400, 1401, 1404, 1405, 1408, 1409, 1412, 1413, 1416, 1417, 1420, 1421, 1424, 1425, 1428, 1429, 1432, 1433, 1436, 1437, 1440, 1441, 1444, 1445, 1448, 1449, 1452, 1453, 1456, 1457, 1460, 1461, 1464, 1465, 1468, 1469, 1472, 1473, 1476, 1477, 1480, 1481, 1484, 1485, 1488, 1489, 1492, 1493, 1496, 1497, 1500, 1501, 1504, 1505, 1508, 1509, 1512, 1513, 1516, 1517, 1520, 1521, 1524, 1525, 1528, 1529, 1532, 1533, 1536, 1537, 1540, 1541, 1544, 1545, 1548, 1549, 1552, 1553, 1556, 1557, 1560, 1561, 1564, 1565, 1568, 1569, 1572, 1573, 1576, 1577, 1580, 1581, 1584, 1585, 1588, 1589, 1592, 1593, 1596, 1597, 1600, 1601, 1604, 1605, 1608, 1609, 1612, 1613, 1616, 1617, 1620, 1621, 1624, 1625, 1628, 1629, 1632, 1633, 1636, 1637, 1640, 1641, 1644, 1645, 1648, 1649, 1652, 1653, 1656, 1657, 1660, 1661, 1664, 1665, 1668, 1669, 1672, 1673, 1676, 1677, 1680, 1681, 1684, 1685, 1688, 1689, 1692, 1693, 1696, 1697, 1700, 1701, 1704, 1705, 1708, 1709, 1712, 1713, 1716, 1717, 1720, 1721, 1724, 1725, 1728, 1729, 1732, 1733, 1736, 1737, 1740, 1741, 1744, 1745, 1748, 1749, 1752, 1753, 1756, 1757, 1760, 1761, 1764, 1765, 1768, 1769, 1772, 1773, 1776, 1777, 1780, 1781, 1784, 1785, 1788, 1789, 1792, 1793, 1796, 1797, 1800, 1801, 1804, 1805, 1808, 1809, 1812, 1813, 1816, 1817, 1820, 1821, 1824, 1825, 1828, 1829, 1832, 1833, 1836, 1837, 1840, 1841, 1844, 1845, 1848, 1849, 1852, 1853, 1856, 1857, 1860, 1861, 1864, 1865, 1868, 1869, 1872, 1873, 1876, 1877, 1880, 1881, 1884, 1885, 1888, 1889, 1892, 1893, 1896, 1897, 1900, 1901, 1904, 1905, 1908, 1909, 1912, 1913, 1916, 1917, 1920 or 1921. The nucleobase sequence of the sense strand may comprise or consist of a nucleobase sequence that is at least 95% identical to any of SEQ ID NOs: 4, 8, 12, 16, 20, 24, 28, 32, 36, 40, 44, 48, 52, 56, 60, 64, 68, 72, 76, 80, 84, 88, 92, 96, 100, 104, 108, 112, 116, 120, 124, 128, 132, 136, 140, 144, 148, 152, 156, 160, 164, 168, 172, 176, 180, 184, 188, 192, 196, 200, 204, 208, 212, 216, 220, 224, 228, 232, 236, 240, 244, 248, 252, 256, 260, 264, 268, 272, 276, 280, 284, 288, 292, 296, 300, 304, 308, 312, 316, 320, 324, 328, 332, 336, 340, 344, 348, 352, 356, 360, 364, 368, 372, 376, 380, 384, 388, 392, 396, 400, 404, 408, 412, 416, 420, 424, 428, 432, 436, 440, 444, 448, 452, 456, 460, 464, 468, 472, 476, 480, 484, 488, 492, 496, 500, 504, 508, 512, 516, 520, 524, 528, 532, 536, 540, 544, 548, 552, 556, 560, 564, 568, 572, 576, 580, 584, 588, 592, 596, 600, 604, 608, 612, 616, 620, 624, 628, 632, 636, 640, 644, 648, 652, 656, 660, 664, 668, 672, 676, 680, 684, 688, 692, 696, 700, 704, 708, 712, 716, 720, 724, 728, 732, 736, 740, 744, 748, 752, 756, 760, 764, 768, 772, 776, 780, 784, 788, 792, 796, 800, 804, 808, 812, 816, 820, 824, 828, 832, 836, 840, 844, 848, 852, 856, 860, 864, 868, 872, 876, 880, 884, 888, 892, 896, 900, 904, 908, 912, 916, 920, 924, 928, 932, 936, 940, 944, 948, 952, 956, 960, 964, 968, 972, 976, 980, 984, 988, 992, 996, 1000, 1004, 1008, 1012, 1016, 1020, 1024, 1028, 1032, 1036, 1040, 1044, 1048, 1052, 1056, 1060, 1064, 1068, 1072, 1076, 1080, 1084, 1088, 1092, 1096, 1100, 1104, 1108, 1112, 1116, 1120, 1124, 1128, 1132, 1136, 1140, 1144, 1148, 1152, 1156, 1160, 1164, 1168, 1172, 1176, 1180, 1184, 1188, 1192, 1196, 1200, 1204, 1208, 1212, 1216, 1220, 1224, 1228, 1232, 1236, 1240, 1244, 1248, 1252, 1256, 1260, 1264, 1268, 1272, 1276, 1280, 1284, 1288, 1292, 1296, 1300, 1304, 1308, 1312, 1316, 1320, 1324, 1328, 1332, 1336, 1340, 1344, 1348, 1352, 1356, 1360, 1364, 1368, 1372, 1376, 1380, 1384, 1388, 1392, 1396, 1400, 1404, 1408, 1412, 1416, 1420, 1424, 1428, 1432, 1436, 1440, 1444, 1448, 1452, 1456, 1460, 1464, 1468, 1472, 1476, 1480, 1484, 1488, 1492, 1496, 1500, 1504, 1508, 1512, 1516, 1520, 1524, 1528, 1532, 1536, 1540, 1544, 1548, 1552, 1556, 1560, 156...

Claims

CLAIMS:

1. A double-stranded oligonucleotide comprising an antisense strand comprising a nucleobase sequence that is at least 80% complementary to an equal length portion of a PSD3 nucleic acid having the nucleobase sequence of SEQ ID NO: 1, and a sense strand.

2. The double-stranded oligonucleotide of claim 1, wherein the antisense strand comprises a nucleobase sequence that is at least 80% complementary to an equal length portion within a nucleobase sequence corresponding to nucleobases 1 to 8100, particularly 1 to 600, 1400 to 3500 or 7500 to 8100 of SEQ ID NO:

1.

3. The double-stranded oligonucleotide of claim 2, wherein the antisense strand comprises a nucleobase sequence that is at least 85%, at least 90%, at least 95%, or 100% complementary to said equal length portion within a nucleobase sequence corresponding to nucleobases 1 to 8100, particularly 1 to 600, 1400 to 3500 or 7500 to 8100 of SEQ ID NO:

1.

4. The double-stranded oligonucleotide of any one of the preceding claims, wherein the nucleobase sequence of the antisense strand comprises or consists of a nucleobase sequence that is at least 85%, at least 90%, at least 95%, or 100% identical to any of SEQ ID NOs: 2, 3, 6, 7, 10, 11, 14, 15, 18, 19, 22, 23, 26, 27, 30, 31, 34, 35, 38, 39, 42, 43, 46, 47, 50, 51, 54, 55, 58, 59, 62, 63, 66, 67, 70, 71, 74, 75, 78, 79, 82, 83, 86, 87, 90, 91, 94, 95, 98, 99, 102, 103, 106, 107, 110, 111, 114, 115, 118, 119, 122, 123, 126, 127, 130, 131, 134, 135, 138, 139, 142, 143, 146, 147, 150, 151, 154, 155, 158, 159, 162, 163, 166, 167, 170, 171, 174, 175, 178, 179, 182, 183, 186, 187, 190, 191, 194, 195, 198, 199, 202, 203, 206, 207, 210, 211, 214, 215, 218, 219, 222, 223, 226, 227, 230, 231, 234, 235, 238, 239, 242, 243, 246, 247, 250, 251, 254, 255, 258, 259, 262, 263, 266, 267, 270, 271, 274, 275, 278, 279, 282, 283, 286, 287, 290, 291, 294, 295, 298, 299, 302, 303, 306, 307, 310, 311, 314, 315, 318, 319, 322, 323, 326, 327, 330, 331, 334, 335, 338, 339, 342, 343, 346, 347, 350, 351, 354, 355, 358, 359, 362, 363, 366, 367, 370, 371, 374, 375, 378, 379, 382, 383, 386, 387, 390, 391, 394, 395, 398, 399, 402, 403, 406, 407, 410, 411, 414, 415, 418, 419, 422, 423, 426, 427, 430, 431, 434, 435, 438, 439, 442, 443, 446, 447, 450, 451, 454, 455, 458, 459, 462, 463, 466, 467, 470, 471, 474, 475, 478, 479, 482, 483, 486, 487, 490, 491, 494, 495, 498, 499, 502, 503, 506, 507, 510, 511, 514, 515, 518, 519, 522, 523, 526, 527, 530, 531, 534, 535, 538, 539, 542, 543, 546, 547, 550, 551, 554, 555, 558, 559, 562, 563, 566, 567, 570, 571, 574, 575, 578, 579, 582, 583, 586, 587, 590, 591, 594, 595, 598, 599, 602, 603, 606, 607, 610, 611, 614, 615, 618, 619, 622, 623, 626, 627, 630, 631, 634, 635, 638, 639, 642, 643, 646, 647, 650, 651, 654, 655, 658, 659, 662, 663, 666, 667, 670, 671, 674, 675, 678, 679, 682, 683, 686, 687, 690, 691, 694, 695, 698, 699, 702, 703, 706, 707, 710, 711, 714, 715, 718, 719, 722, 723, 726, 727, 730, 731, 734, 735, 738, 739, 742, 743, 746, 747, 750, 751, 754, 755, 758, 759, 762, 763, 766, 767, 770, 771, 774, 775, 778, 779, 782, 783, 786, 787, 790, 791, 794, 795, 798, 799, 802, 803, 806, 807, 810, 811, 814, 815, 818, 819, 822, 823, 826, 827, 830, 831, 834, 835, 838, 839, 842, 843, 846, 847, 850, 851, 854, 855, 858, 859, 862, 863, 866, 867, 870, 871, 874, 875, 878, 879, 882, 883, 886, 887, 890, 891, 894, 895, 898, 899, 902, 903, 906, 907, 910, 911, 914, 915, 918, 919, 922, 923, 926, 927, 930, 931, 934, 935, 938, 939, 942, 943, 946, 947, 950, 951, 954, 955, 958, 959, 962, 963, 966, 967, 970, 971, 974, 975, 978, 979, 982, 983, 986, 987, 990, 991, 994, 995, 998, 999, 1002, 1003, 1006,1007, 1010, 1011, 1014, 1015, 1018, 1019, 1022, 1023, 1026, 1027, 1030, 1031, 1034, 1035, 1038, 1039, 1042, 1043, 1046, 1047, 1050, 1051, 1054, 1055, 1058, 1059, 1062, 1063, 1066, 1067, 1070, 1071, 1074, 1075, 1078, 1079, 1082, 1083, 1086, 1087, 1090, 1091, 1094, 1095, 1098, 1099, 1102, 1103, 1106, 1107, 1110, 1111, 1114, 1115, 1118, 1119, 1122, 1123, 1126, 1127, 1130, 1131, 1134, 1135, 1138, 1139, 1142, 1143, 1146, 1147, 1150, 1151, 1154, 1155, 1158, 1159, 1162, 1163, 1166, 1167, 1170, 1171, 1174, 1175, 1178, 1179, 1182, 1183, 1186, 1187, 1190, 1191, 1194, 1195, 1198, 1199, 1202, 1203, 1206, 1207, 1210, 1211, 1214, 1215, 1218, 1219, 1222, 1223, 1226, 1227, 1230, 1231, 1234, 1235, 1238, 1239, 1242, 1243, 1246, 1247, 1250, 1251, 1254, 1255, 1258, 1259, 1262, 1263, 1266, 1267, 1270, 1271, 1274, 1275, 1278, 1279, 1282, 1283, 1286, 1287, 1290, 1291, 1294, 1295, 1298, 1299, 1302, 1303, 1306, 1307, 1310, 1311, 1314, 1315, 1318, 1319, 1322, 1323, 1326, 1327, 1330, 1331, 1334, 1335, 1338, 1339, 1342, 1343, 1346, 1347, 1350, 1351, 1354, 1355, 1358, 1359, 1362, 1363, 1366, 1367, 1370, 1371, 1374, 1375, 1378, 1379, 1382, 1383, 1386, 1387, 1390, 1391, 1394, 1395, 1398, 1399, 1402, 1403, 1406, 1407, 1410, 1411, 1414, 1415, 1418, 1419, 1422, 1423, 1426, 1427, 1430, 1431, 1434, 1435, 1438, 1439, 1442, 1443, 1446, 1447, 1450, 1451, 1454, 1455, 1458, 1459, 1462, 1463, 1466, 1467, 1470, 1471, 1474, 1475, 1478, 1479, 1482, 1483, 1486, 1487, 1490, 1491, 1494, 1495, 1498, 1499, 1502, 1503, 1506, 1507, 1510, 1511, 1514, 1515, 1518, 1519, 1522, 1523, 1526, 1527, 1530, 1531, 1534, 1535, 1538, 1539, 1542, 1543, 1546, 1547, 1550, 1551, 1554, 1555, 1558, 1559, 1562, 1563, 1566, 1567, 1570, 1571, 1574, 1575, 1578, 1579, 1582, 1583, 1586, 1587, 1590, 1591, 1594, 1595, 1598, 1599, 1602, 1603, 1606, 1607, 1610, 1611, 1614, 1615, 1618, 1619, 1622, 1623, 1626, 1627, 1630, 1631, 1634, 1635, 1638, 1639, 1642, 1643, 1646, 1647, 1650, 1651, 1654, 1655, 1658, 1659, 1662, 1663, 1666, 1667, 1670, 1671, 1674, 1675, 1678, 1679, 1682, 1683, 1686, 1687, 1690, 1691, 1694, 1695, 1698, 1699, 1702, 1703, 1706, 1707, 1710, 1711, 1714, 1715, 1718, 1719, 1722, 1723, 1726, 1727, 1730, 1731, 1734, 1735, 1738, 1739, 1742, 1743, 1746, 1747, 1750, 1751, 1754, 1755, 1758, 1759, 1762, 1763, 1766, 1767, 1770, 1771, 1774, 1775, 1778, 1779, 1782, 1783, 1786, 1787, 1790, 1791, 1794, 1795, 1798, 1799, 1802, 1803, 1806, 1807, 1810, 1811, 1814, 1815, 1818, 1819, 1822, 1823, 1826, 1827, 1830, 1831, 1834, 1835, 1838, 1839, 1842, 1843, 1846, 1847, 1850, 1851, 1854, 1855, 1858, 1859, 1862, 1863, 1866, 1867, 1870, 1871, 1874, 1875, 1878, 1879, 1882, 1883, 1886, 1887, 1890, 1891, 1894, 1895, 1898, 1899, 1902, 1903, 1906, 1907, 1910, 1911, 1914, 1915, 1918 or 1919, preferably any one of SEQ ID Nos: 34, 35, 54, 55, 58, 59, 142, 143, 158, 159, 250, 251, 262, 263, 282, 283, 286, 287, 390, 391, 398, 399, 426, 427, 470, 471, 478, 479, 494, 495, 502, 503, 522, 523, 566, 567, 574, 575, 586, 587, 606, 607, 618, 619, 626, 627, 654, 655, 666, 667, 678, 679, 694, 695, 698, 699, 722, 723, 730, 731, 742, 743, 778, 779, 802, 803, 822, 823, 830, 831, 842, 843, 846, 847, 858, 859, 862, 863, 866, 867, 870, 871, 874, 875, 878, 879, 886, 887, 906, 907, 914, 915, 946, 947, 954, 955, 970, 971, 978, 979, 1006, 1007, 1018, 1019, 1022, 1023, 1026, 1027, 1034, 1035, 1038, 1039, 1042, 1043, 1058, 1059, 1082, 1083, 1086, 1087, 1102, 1103, 1118, 1119, 1126, 1127, 1142, 1143, 1146, 1147, 1150, 1151, 1154, 1155, 1158, 1159, 1182, 1183, 1186, 1187, 1190, 1191, 1210, 1211, 1214, 1215, 1254, 1255, 1270, 1271, 1274, 1275, 1278, 1279, 1282, 1283, 1294, 1295, 1298, 1299, 1302, 1303, 1310, 1311, 1330, 1331, 1334, 1335, 1346, 1347, 1354, 1355, 1358, 1359, 1362, 1363, 1366, 1367, 1602, 1603, 1614, 1615, 1618, 1619, 1626, 1627, 1630 or 1631.

5. The double-stranded oligonucleotide of any one of the preceding claims, wherein the antisense strand has a nucleobase sequence comprising at least 15, at least 16, at least 17, at least 18, at least 19, at least 20, at least 21,at least 22, or at least 23 contiguous nucleobases, particularly 19, 20, 21, 22 or 23 contiguous nucleobases of any of the nucleobase sequences of any of SEQ ID NOs: 2, 3, 6, 7, 10, 11, 14, 15, 18, 19, 22, 23, 26, 27, 30, 31, 34, 35, 38, 39, 42, 43, 46, 47, 50, 51, 54, 55, 58, 59, 62, 63, 66, 67, 70, 71, 74, 75, 78, 79, 82, 83,86, 87, 90, 91, 94, 95, 98, 99, 102, 103, 106, 107, 110, 111, 114, 115, 118, 119, 122, 123, 126, 127, 130, 131, 134, 135, 138, 139, 142, 143, 146, 147, 150, 151, 154, 155, 158, 159, 162, 163, 166, 167, 170, 171, 174, 175, 178, 179, 182, 183, 186, 187, 190, 191, 194, 195, 198, 199, 202, 203, 206, 207, 210, 211, 214, 215, 218, 219, 222, 223, 226, 227, 230, 231, 234, 235, 238, 239, 242, 243, 246, 247, 250, 251, 254, 255, 258, 259, 262, 263, 266, 267, 270, 271, 274, 275, 278, 279, 282, 283, 286, 287, 290, 291, 294, 295, 298, 299, 302, 303, 306, 307, 310, 311, 314, 315, 318, 319, 322, 323, 326, 327, 330, 331, 334, 335, 338, 339, 342, 343, 346, 347, 350, 351, 354, 355, 358, 359, 362, 363, 366, 367, 370, 371, 374, 375, 378, 379, 382, 383, 386, 387, 390, 391, 394, 395, 398, 399, 402, 403, 406, 407, 410, 411, 414, 415, 418, 419, 422, 423, 426, 427, 430, 431, 434, 435, 438, 439, 442, 443, 446, 447, 450, 451, 454, 455, 458, 459, 462, 463, 466, 467, 470, 471, 474, 475, 478, 479, 482, 483, 486, 487, 490, 491, 494, 495, 498, 499, 502, 503, 506, 507, 510, 511, 514, 515, 518, 519, 522, 523, 526, 527, 530, 531, 534, 535, 538, 539, 542, 543, 546, 547, 550, 551, 554, 555, 558, 559, 562, 563, 566, 567, 570, 571, 574, 575, 578, 579, 582, 583, 586, 587, 590, 591, 594, 595, 598, 599, 602, 603, 606, 607, 610, 611, 614, 615, 618, 619, 622, 623, 626, 627, 630, 631, 634, 635, 638, 639, 642, 643, 646, 647, 650, 651, 654, 655, 658, 659, 662, 663, 666, 667, 670, 671, 674, 675, 678, 679, 682, 683, 686, 687, 690, 691, 694, 695, 698, 699, 702, 703, 706, 707, 710, 711, 714, 715, 718, 719, 722, 723, 726, 727, 730, 731, 734, 735, 738, 739, 742, 743, 746, 747, 750, 751, 754, 755, 758, 759, 762, 763, 766, 767, 770, 771, 774, 775, 778, 779, 782, 783, 786, 787, 790, 791, 794, 795, 798, 799, 802, 803, 806, 807, 810, 811, 814, 815, 818, 819, 822, 823, 826, 827, 830, 831, 834, 835, 838, 839, 842, 843, 846, 847, 850, 851, 854, 855, 858, 859, 862, 863, 866, 867, 870, 871, 874, 875, 878, 879, 882, 883, 886, 887, 890, 891, 894, 895, 898, 899, 902, 903, 906, 907, 910, 911, 914, 915, 918, 919, 922, 923, 926, 927, 930, 931, 934, 935, 938, 939, 942, 943, 946, 947, 950, 951, 954, 955, 958, 959, 962, 963, 966, 967, 970, 971, 974, 975, 978, 979, 982, 983, 986, 987, 990, 991, 994, 995, 998, 999, 1002, 1003, 1006, 1007, 1010, 1011, 1014, 1015, 1018, 1019, 1022, 1023, 1026, 1027, 1030, 1031, 1034, 1035, 1038, 1039, 1042, 1043, 1046, 1047, 1050, 1051, 1054, 1055, 1058, 1059, 1062, 1063, 1066, 1067, 1070, 1071, 1074, 1075, 1078, 1079, 1082, 1083, 1086, 1087, 1090, 1091, 1094, 1095, 1098, 1099, 1102, 1103, 1106, 1107, 1110, 1111, 1114, 1115, 1118, 1119, 1122, 1123, 1126, 1127, 1130, 1131, 1134, 1135, 1138, 1139, 1142, 1143, 1146, 1147, 1150, 1151, 1154, 1155, 1158, 1159, 1162, 1163, 1166, 1167, 1170, 1171, 1174, 1175, 1178, 1179, 1182, 1183, 1186, 1187, 1190, 1191, 1194, 1195, 1198, 1199, 1202, 1203, 1206, 1207, 1210, 1211, 1214, 1215, 1218, 1219, 1222, 1223, 1226, 1227, 1230, 1231, 1234, 1235, 1238, 1239, 1242, 1243, 1246, 1247, 1250, 1251, 1254, 1255, 1258, 1259, 1262, 1263, 1266, 1267, 1270, 1271, 1274, 1275, 1278, 1279, 1282, 1283, 1286, 1287, 1290, 1291, 1294, 1295, 1298, 1299, 1302, 1303, 1306, 1307, 1310, 1311, 1314, 1315, 1318, 1319, 1322, 1323, 1326, 1327, 1330, 1331, 1334, 1335, 1338, 1339, 1342, 1343, 1346, 1347, 1350, 1351, 1354, 1355, 1358, 1359, 1362, 1363, 1366, 1367, 1370, 1371, 1374, 1375, 1378, 1379, 1382, 1383, 1386, 1387, 1390, 1391, 1394, 1395, 1398, 1399, 1402, 1403, 1406, 1407, 1410, 1411, 1414, 1415, 1418, 1419, 1422, 1423, 1426, 1427, 1430, 1431, 1434, 1435, 1438, 1439, 1442, 1443, 1446, 1447, 1450, 1451, 1454, 1455, 1458, 1459, 1462, 1463, 1466, 1467, 1470, 1471, 1474, 1475, 1478, 1479, 1482, 1483, 1486, 1487, 1490, 1491, 1494, 1495, 1498, 1499, 1502, 1503, 1506, 1507, 1510, 1511, 1514, 1515, 1518, 1519, 1522, 1523, 1526, 1527, 1530, 1531, 1534, 1535, 1538, 1539, 1542, 1543, 1546, 1547, 1550, 1551, 1554, 1555, 1558, 1559, 1562, 1563, 1566, 1567, 1570, 1571, 1574, 1575, 1578, 1579, 1582, 1583, 1586, 1587, 1590, 1591, 1594, 1595, 1598, 1599, 1602, 1603, 1606, 1607, 1610, 1611, 1614, 1615, 1618, 1619, 1622, 1623, 1626, 1627, 1630, 1631, 1634, 1635, 1638, 1639, 1642, 1643, 1646, 1647, 1650, 1651, 1654, 1655, 1658, 1659, 1662, 1663, 1666, 1667, 1670, 1671, 1674, 1675, 1678, 1679, 1682, 1683, 1686, 1687, 1690, 1691, 1694, 1695, 1698, 1699, 1702, 1703, 1706, 1707, 1710, 1711, 1714, 1715, 1718, 1719, 1722, 1723, 1726,1727, 1730, 1731, 1734, 1735, 1738, 1739, 1742, 1743, 1746, 1747, 1750, 1751, 1754, 1755, 1758, 1759, 1762, 1763, 1766, 1767, 1770, 1771, 1774, 1775, 1778, 1779, 1782, 1783, 1786, 1787, 1790, 1791, 1794, 1795, 1798, 1799, 1802, 1803, 1806, 1807, 1810, 1811, 1814, 1815, 1818, 1819, 1822, 1823, 1826, 1827, 1830, 1831, 1834, 1835, 1838, 1839, 1842, 1843, 1846, 1847, 1850, 1851, 1854, 1855, 1858, 1859, 1862, 1863, 1866, 1867, 1870, 1871, 1874, 1875, 1878, 1879, 1882, 1883, 1886, 1887, 1890, 1891, 1894, 1895, 1898, 1899, 1902, 1903, 1906, 1907, 1910, 1911, 1914, 1915, 1918 or 1919, preferably any one of SEQ ID Nos: 34, 35, 54, 55, 58, 59, 142, 143, 158, 159, 250, 251, 262, 263, 282, 283, 286, 287, 390, 391, 398, 399, 426, 427, 470, 471, 478, 479, 494, 495, 502, 503, 522, 523, 566, 567, 574, 575, 586, 587, 606, 607, 618, 619, 626, 627, 654, 655, 666, 667, 678, 679, 694, 695, 698, 699, 722, 723, 730, 731, 742, 743, 778, 779, 802, 803, 822, 823, 830, 831, 842, 843, 846, 847, 858, 859, 862, 863, 866, 867, 870, 871, 874, 875, 878, 879, 886, 887, 906, 907, 914, 915, 946, 947, 954, 955, 970, 971, 978, 979, 1006, 1007, 1018, 1019, 1022, 1023, 1026, 1027, 1034, 1035, 1038, 1039, 1042, 1043, 1058, 1059, 1082, 1083, 1086, 1087, 1102, 1103, 1118, 1119, 1126, 1127, 1142, 1143, 1146, 1147, 1150, 1151, 1154, 1155, 1158, 1159, 1182, 1183, 1186, 1187, 1190, 1191, 1210, 1211, 1214, 1215, 1254, 1255, 1270, 1271, 1274, 1275, 1278, 1279, 1282, 1283, 1294, 1295, 1298, 1299, 1302, 1303, 1310, 1311, 1330, 1331, 1334, 1335, 1346, 1347, 1354, 1355, 1358, 1359, 1362, 1363, 1366, 1367, 1602, 1603, 1614, 1615, 1618, 1619, 1626, 1627, 1630 or 1631.

6. The double-stranded oligonucleotide of any one of the preceding claims, wherein the nucleobase sequence of the antisense strand comprises the nucleobase sequence of any of SEQ ID NOs: 2, 3, 6, 7, 10, 11, 14, 15, 18, 19, 22, 23, 26, 27, 30, 31, 34, 35, 38, 39, 42, 43, 46, 47, 50, 51, 54, 55, 58, 59, 62, 63, 66, 67, 70, 71, 74, 75, 78, 79, 82, 83, 86, 87, 90, 91, 94, 95, 98, 99, 102, 103, 106, 107, 110, 111, 114, 115, 118, 119, 122, 123, 126, 127, 130, 131, 134, 135, 138, 139, 142, 143, 146, 147, 150, 151, 154, 155, 158, 159, 162, 163, 166, 167, 170, 171, 174, 175, 178, 179, 182, 183, 186, 187, 190, 191, 194, 195, 198, 199, 202, 203, 206, 207, 210, 211, 214, 215, 218, 219, 222, 223, 226, 227, 230, 231, 234, 235, 238, 239, 242, 243, 246, 247, 250, 251, 254, 255, 258, 259, 262, 263, 266, 267, 270, 271, 274, 275, 278, 279, 282, 283, 286, 287, 290, 291, 294, 295, 298, 299, 302, 303, 306, 307, 310, 311, 314, 315, 318, 319, 322, 323, 326, 327, 330, 331, 334, 335, 338, 339, 342, 343, 346, 347, 350, 351, 354, 355, 358, 359, 362, 363, 366, 367, 370, 371, 374, 375, 378, 379, 382, 383, 386, 387, 390, 391, 394, 395, 398, 399, 402, 403, 406, 407, 410, 411, 414, 415, 418, 419, 422, 423, 426, 427, 430, 431, 434, 435, 438, 439, 442, 443, 446, 447, 450, 451, 454, 455, 458, 459, 462, 463, 466, 467, 470, 471, 474, 475, 478, 479, 482, 483, 486, 487, 490, 491, 494, 495, 498, 499, 502, 503, 506, 507, 510, 511, 514, 515, 518, 519, 522, 523, 526, 527, 530, 531, 534, 535, 538, 539, 542, 543, 546, 547, 550, 551, 554, 555, 558, 559, 562, 563, 566, 567, 570, 571, 574, 575, 578, 579, 582, 583, 586, 587, 590, 591, 594, 595, 598, 599, 602, 603, 606, 607, 610, 611, 614, 615, 618, 619, 622, 623, 626, 627, 630, 631, 634, 635, 638, 639, 642, 643, 646, 647, 650, 651, 654, 655, 658, 659, 662, 663, 666, 667, 670, 671, 674, 675, 678, 679, 682, 683, 686, 687, 690, 691, 694, 695, 698, 699, 702, 703, 706, 707, 710, 711, 714, 715, 718, 719, 722, 723, 726, 727, 730, 731, 734, 735, 738, 739, 742, 743, 746, 747, 750, 751, 754, 755, 758, 759, 762, 763, 766, 767, 770, 771, 774, 775, 778, 779, 782, 783, 786, 787, 790, 791, 794, 795, 798, 799, 802, 803, 806, 807, 810, 811, 814, 815, 818, 819, 822, 823, 826, 827, 830, 831, 834, 835, 838, 839, 842, 843, 846, 847, 850, 851, 854, 855, 858, 859, 862, 863, 866, 867, 870, 871, 874, 875, 878, 879, 882, 883, 886, 887, 890, 891, 894, 895, 898, 899, 902, 903, 906, 907, 910, 911, 914, 915, 918, 919, 922, 923, 926, 927, 930, 931, 934, 935, 938, 939, 942, 943, 946, 947, 950, 951, 954, 955, 958, 959, 962, 963, 966, 967, 970, 971, 974, 975, 978, 979, 982, 983, 986, 987, 990, 991, 994, 995, 998, 999, 1002, 1003, 1006, 1007, 1010, 1011, 1014, 1015, 1018, 1019, 1022, 1023, 1026, 1027, 1030, 1031,1034, 1035, 1038, 1039, 1042, 1043, 1046, 1047, 1050, 1051, 1054, 1055, 1058, 1059, 1062, 1063, 1066, 1067, 1070, 1071, 1074, 1075, 1078, 1079, 1082, 1083, 1086, 1087, 1090, 1091, 1094, 1095, 1098, 1099, 1102, 1103, 1106, 1107, 1110, 1111, 1114, 1115, 1118, 1119, 1122, 1123, 1126, 1127, 1130, 1131, 1134, 1135, 1138, 1139, 1142, 1143, 1146, 1147, 1150, 1151, 1154, 1155, 1158, 1159, 1162, 1163, 1166, 1167, 1170, 1171, 1174, 1175, 1178, 1179, 1182, 1183, 1186, 1187, 1190, 1191, 1194, 1195, 1198, 1199, 1202, 1203, 1206, 1207, 1210, 1211, 1214, 1215, 1218, 1219, 1222, 1223, 1226, 1227, 1230, 1231, 1234, 1235, 1238, 1239, 1242, 1243, 1246, 1247, 1250, 1251, 1254, 1255, 1258, 1259, 1262, 1263, 1266, 1267, 1270, 1271, 1274, 1275, 1278, 1279, 1282, 1283, 1286, 1287, 1290, 1291, 1294, 1295, 1298, 1299, 1302, 1303, 1306, 1307, 1310, 1311, 1314, 1315, 1318, 1319, 1322, 1323, 1326, 1327, 1330, 1331, 1334, 1335, 1338, 1339, 1342, 1343, 1346, 1347, 1350, 1351, 1354, 1355, 1358, 1359, 1362, 1363, 1366, 1367, 1370, 1371, 1374, 1375, 1378, 1379, 1382, 1383, 1386, 1387, 1390, 1391, 1394, 1395, 1398, 1399, 1402, 1403, 1406, 1407, 1410, 1411, 1414, 1415, 1418, 1419, 1422, 1423, 1426, 1427, 1430, 1431, 1434, 1435, 1438, 1439, 1442, 1443, 1446, 1447, 1450, 1451, 1454, 1455, 1458, 1459, 1462, 1463, 1466, 1467, 1470, 1471, 1474, 1475, 1478, 1479, 1482, 1483, 1486, 1487, 1490, 1491, 1494, 1495, 1498, 1499, 1502, 1503, 1506, 1507, 1510, 1511, 1514, 1515, 1518, 1519, 1522, 1523, 1526, 1527, 1530, 1531, 1534, 1535, 1538, 1539, 1542, 1543, 1546, 1547, 1550, 1551, 1554, 1555, 1558, 1559, 1562, 1563, 1566, 1567, 1570, 1571, 1574, 1575, 1578, 1579, 1582, 1583, 1586, 1587, 1590, 1591, 1594, 1595, 1598, 1599, 1602, 1603, 1606, 1607, 1610, 1611, 1614, 1615, 1618, 1619, 1622, 1623, 1626, 1627, 1630, 1631, 1634, 1635, 1638, 1639, 1642, 1643, 1646, 1647, 1650, 1651, 1654, 1655, 1658, 1659, 1662, 1663, 1666, 1667, 1670, 1671, 1674, 1675, 1678, 1679, 1682, 1683, 1686, 1687, 1690, 1691, 1694, 1695, 1698, 1699, 1702, 1703, 1706, 1707, 1710, 1711, 1714, 1715, 1718, 1719, 1722, 1723, 1726, 1727, 1730, 1731, 1734, 1735, 1738, 1739, 1742, 1743, 1746, 1747, 1750, 1751, 1754, 1755, 1758, 1759, 1762, 1763, 1766, 1767, 1770, 1771, 1774, 1775, 1778, 1779, 1782, 1783, 1786, 1787, 1790, 1791, 1794, 1795, 1798, 1799, 1802, 1803, 1806, 1807, 1810, 1811, 1814, 1815, 1818, 1819, 1822, 1823, 1826, 1827, 1830, 1831, 1834, 1835, 1838, 1839, 1842, 1843, 1846, 1847, 1850, 1851, 1854, 1855, 1858, 1859, 1862, 1863, 1866, 1867, 1870, 1871, 1874, 1875, 1878, 1879, 1882, 1883, 1886, 1887, 1890, 1891, 1894, 1895, 1898, 1899, 1902, 1903, 1906, 1907, 1910, 1911, 1914, 1915, 1918 or 1919, preferably any one of SEQ ID Nos: 34, 35, 54, 55, 58, 59, 142, 143, 158, 159, 250, 251, 262, 263, 282, 283, 286, 287, 390, 391, 398, 399, 426, 427, 470, 471, 478, 479, 494, 495, 502, 503, 522, 523, 566, 567, 574, 575, 586, 587, 606, 607, 618, 619, 626, 627, 654, 655, 666, 667, 678, 679, 694, 695, 698, 699, 722, 723, 730, 731, 742, 743, 778, 779, 802, 803, 822, 823, 830, 831, 842, 843, 846, 847, 858, 859, 862, 863, 866, 867, 870, 871, 874, 875, 878, 879, 886, 887, 906, 907, 914, 915, 946, 947, 954, 955, 970, 971, 978, 979, 1006, 1007, 1018, 1019, 1022, 1023, 1026, 1027, 1034, 1035, 1038, 1039, 1042, 1043, 1058, 1059, 1082, 1083, 1086, 1087, 1102, 1103, 1118, 1119, 1126, 1127, 1142, 1143, 1146, 1147, 1150, 1151, 1154, 1155, 1158, 1159, 1182, 1183, 1186, 1187, 1190, 1191, 1210, 1211, 1214, 1215, 1254, 1255, 1270, 1271, 1274, 1275, 1278, 1279, 1282, 1283, 1294, 1295, 1298, 1299, 1302, 1303, 1310, 1311, 1330, 1331, 1334, 1335, 1346, 1347, 1354, 1355, 1358, 1359, 1362, 1363, 1366, 1367, 1602, 1603, 1614, 1615, 1618, 1619, 1626, 1627, 1630 or 1631.

7. The double-stranded oligonucleotide of any one of the preceding claims, wherein the nucleobase sequence of the antisense strand consists of the nucleobase sequence of any of SEQ ID NOs: 2, 3, 6, 7, 10, 11, 14, 15, 18, 19, 22, 23, 26, 27, 30, 31, 34, 35, 38, 39, 42, 43, 46, 47, 50, 51, 54, 55, 58, 59, 62, 63, 66, 67, 70, 71, 74, 75, 78, 79, 82, 83, 86, 87, 90, 91, 94, 95, 98, 99, 102, 103, 106, 107, 110, 111, 114, 115, 118, 119,122, 123, 126, 127, 130, 131, 134, 135, 138, 139, 142, 143, 146, 147, 150, 151, 154, 155, 158, 159, 162, 163, 166, 167, 170, 171, 174, 175, 178, 179, 182, 183, 186, 187, 190, 191, 194, 195, 198, 199, 202, 203, 206, 207, 210, 211, 214, 215, 218, 219, 222, 223, 226, 227, 230, 231, 234, 235, 238, 239, 242, 243, 246, 247, 250, 251, 254, 255, 258, 259, 262, 263, 266, 267, 270, 271, 274, 275, 278, 279, 282, 283, 286, 287, 290, 291, 294, 295, 298, 299, 302, 303, 306, 307, 310, 311, 314, 315, 318, 319, 322, 323, 326, 327, 330, 331, 334, 335, 338, 339, 342, 343, 346, 347, 350, 351, 354, 355, 358, 359, 362, 363, 366, 367, 370, 371, 374, 375, 378, 379, 382, 383, 386, 387, 390, 391, 394, 395, 398, 399, 402, 403, 406, 407, 410, 411, 414, 415, 418, 419, 422, 423, 426, 427, 430, 431, 434, 435, 438, 439, 442, 443, 446, 447, 450, 451, 454, 455, 458, 459, 462, 463, 466, 467, 470, 471, 474, 475, 478, 479, 482, 483, 486, 487, 490, 491, 494, 495, 498, 499, 502, 503, 506, 507, 510, 511, 514, 515, 518, 519, 522, 523, 526, 527, 530, 531, 534, 535, 538, 539, 542, 543, 546, 547, 550, 551, 554, 555, 558, 559, 562, 563, 566, 567, 570, 571, 574, 575, 578, 579, 582, 583, 586, 587, 590, 591, 594, 595, 598, 599, 602, 603, 606, 607, 610, 611, 614, 615, 618, 619, 622, 623, 626, 627, 630, 631, 634, 635, 638, 639, 642, 643, 646, 647, 650, 651, 654, 655, 658, 659, 662, 663, 666, 667, 670, 671, 674, 675, 678, 679, 682, 683, 686, 687, 690, 691, 694, 695, 698, 699, 702, 703, 706, 707, 710, 711, 714, 715, 718, 719, 722, 723, 726, 727, 730, 731, 734, 735, 738, 739, 742, 743, 746, 747, 750, 751, 754, 755, 758, 759, 762, 763, 766, 767, 770, 771, 774, 775, 778, 779, 782, 783, 786, 787, 790, 791, 794, 795, 798, 799, 802, 803, 806, 807, 810, 811, 814, 815, 818, 819, 822, 823, 826, 827, 830, 831, 834, 835, 838, 839, 842, 843, 846, 847, 850, 851, 854, 855, 858, 859, 862, 863, 866, 867, 870, 871, 874, 875, 878, 879, 882, 883, 886, 887, 890, 891, 894, 895, 898, 899, 902, 903, 906, 907, 910, 911, 914, 915, 918, 919, 922, 923, 926, 927, 930, 931, 934, 935, 938, 939, 942, 943, 946, 947, 950, 951, 954, 955, 958, 959, 962, 963, 966, 967, 970, 971, 974, 975, 978, 979, 982, 983, 986, 987, 990, 991, 994, 995, 998, 999, 1002, 1003, 1006, 1007, 1010, 1011, 1014, 1015, 1018, 1019, 1022, 1023, 1026, 1027, 1030, 1031, 1034, 1035, 1038, 1039, 1042, 1043, 1046, 1047, 1050, 1051, 1054, 1055, 1058, 1059, 1062, 1063, 1066, 1067, 1070, 1071, 1074, 1075, 1078, 1079, 1082, 1083, 1086, 1087, 1090, 1091, 1094, 1095, 1098, 1099, 1102, 1103, 1106, 1107, 1110, 1111, 1114, 1115, 1118, 1119, 1122, 1123, 1126, 1127, 1130, 1131, 1134, 1135, 1138, 1139, 1142, 1143, 1146, 1147, 1150, 1151, 1154, 1155, 1158, 1159, 1162, 1163, 1166, 1167, 1170, 1171, 1174, 1175, 1178, 1179, 1182, 1183, 1186, 1187, 1190, 1191, 1194, 1195, 1198, 1199, 1202, 1203, 1206, 1207, 1210, 1211, 1214, 1215, 1218, 1219, 1222, 1223, 1226, 1227, 1230, 1231, 1234, 1235, 1238, 1239, 1242, 1243, 1246, 1247, 1250, 1251, 1254, 1255, 1258, 1259, 1262, 1263, 1266, 1267, 1270, 1271, 1274, 1275, 1278, 1279, 1282, 1283, 1286, 1287, 1290, 1291, 1294, 1295, 1298, 1299, 1302, 1303, 1306, 1307, 1310, 1311, 1314, 1315, 1318, 1319, 1322, 1323, 1326, 1327, 1330, 1331, 1334, 1335, 1338, 1339, 1342, 1343, 1346, 1347, 1350, 1351, 1354, 1355, 1358, 1359, 1362, 1363, 1366, 1367, 1370, 1371, 1374, 1375, 1378, 1379, 1382, 1383, 1386, 1387, 1390, 1391, 1394, 1395, 1398, 1399, 1402, 1403, 1406, 1407, 1410, 1411, 1414, 1415, 1418, 1419, 1422, 1423, 1426, 1427, 1430, 1431, 1434, 1435, 1438, 1439, 1442, 1443, 1446, 1447, 1450, 1451, 1454, 1455, 1458, 1459, 1462, 1463, 1466, 1467, 1470, 1471, 1474, 1475, 1478, 1479, 1482, 1483, 1486, 1487, 1490, 1491, 1494, 1495, 1498, 1499, 1502, 1503, 1506, 1507, 1510, 1511, 1514, 1515, 1518, 1519, 1522, 1523, 1526, 1527, 1530, 1531, 1534, 1535, 1538, 1539, 1542, 1543, 1546, 1547, 1550, 1551, 1554, 1555, 1558, 1559, 1562, 1563, 1566, 1567, 1570, 1571, 1574, 1575, 1578, 1579, 1582, 1583, 1586, 1587, 1590, 1591, 1594, 1595, 1598, 1599, 1602, 1603, 1606, 1607, 1610, 1611, 1614, 1615, 1618, 1619, 1622, 1623, 1626, 1627, 1630, 1631, 1634, 1635, 1638, 1639, 1642, 1643, 1646, 1647, 1650, 1651, 1654, 1655, 1658, 1659, 1662, 1663, 1666, 1667, 1670, 1671, 1674, 1675, 1678, 1679, 1682, 1683, 1686, 1687, 1690, 1691, 1694, 1695, 1698, 1699, 1702, 1703, 1706, 1707, 1710, 1711, 1714, 1715, 1718, 1719, 1722, 1723, 1726, 1727, 1730, 1731, 1734, 1735, 1738, 1739, 1742, 1743, 1746, 1747, 1750, 1751,1754, 1755, 1758, 1759, 1762, 1763, 1766, 1767, 1770, 1771, 1774, 1775, 1778, 1779, 1782, 1783, 1786, 1787, 1790, 1791, 1794, 1795, 1798, 1799, 1802, 1803, 1806, 1807, 1810, 1811, 1814, 1815, 1818, 1819, 1822, 1823, 1826, 1827, 1830, 1831, 1834, 1835, 1838, 1839, 1842, 1843, 1846, 1847, 1850, 1851, 1854, 1855, 1858, 1859, 1862, 1863, 1866, 1867, 1870, 1871, 1874, 1875, 1878, 1879, 1882, 1883, 1886, 1887, 1890, 1891, 1894, 1895, 1898, 1899, 1902, 1903, 1906, 1907, 1910, 1911, 1914, 1915, 1918 or 1919, preferably any one of SEQ ID Nos: 34, 35, 54, 55, 58, 59, 142, 143, 158, 159, 250, 251, 262, 263, 282, 283, 286, 287, 390, 391, 398, 399, 426, 427, 470, 471, 478, 479, 494, 495, 502, 503, 522, 523, 566, 567, 574, 575, 586, 587, 606, 607, 618, 619, 626, 627, 654, 655, 666, 667, 678, 679, 694, 695, 698, 699, 722, 723, 730, 731, 742, 743, 778, 779, 802, 803, 822, 823, 830, 831, 842, 843, 846, 847, 858, 859, 862, 863, 866, 867, 870, 871, 874, 875, 878, 879, 886, 887, 906, 907, 914, 915, 946, 947, 954, 955, 970, 971, 978, 979, 1006, 1007, 1018, 1019, 1022, 1023, 1026, 1027, 1034, 1035, 1038, 1039, 1042, 1043, 1058, 1059, 1082, 1083, 1086, 1087, 1102, 1103, 1118, 1119, 1126, 1127, 1142, 1143, 1146, 1147, 1150, 1151, 1154, 1155, 1158, 1159, 1182, 1183, 1186, 1187, 1190, 1191, 1210, 1211, 1214, 1215, 1254, 1255, 1270, 1271, 1274, 1275, 1278, 1279, 1282, 1283, 1294, 1295, 1298, 1299, 1302, 1303, 1310, 1311, 1330, 1331, 1334, 1335, 1346, 1347, 1354, 1355, 1358, 1359, 1362, 1363, 1366, 1367, 1602, 1603, 1614, 1615, 1618, 1619, 1626, 1627, 1630 or 1631.

8. The double-stranded oligonucleotide of any one of the preceding claims, wherein the sense strand comprises a nucleobase sequence that is at least 80% identical to said equal length portion within a nucleobase sequence corresponding to nucleobases 1 to 8100, particularly 1 to 600, 1400 to 3500 or 7500 to 8100 of SEQ ID NO:

1.

9. The double-stranded oligonucleotide of any one of the preceding claims, wherein the sense strand comprises a nucleobase sequence that is at least 85%, at least 90%, at least 95%, or 100% identical to said equal length portion within a nucleobase sequence corresponding to nucleobases 1 to 8100, particularly 1 to 600, 1400 to 3500 or 7500 to 8100 of SEQ ID NO:

1.

10. The double-stranded oligonucleotide of any one of the preceding claims, wherein the nucleobase sequence of the sense strand comprises or consists of a nucleobase sequence that is at least 85%, at least 90%, at least 95%, or 100% identical to any of SEQ ID NOs: 4, 5, 8, 9, 12, 13, 16, 17, 20, 21, 24, 25, 28, 29, 32, 33, 36, 37, 40, 41, 44, 45, 48, 49, 52, 53, 56, 57, 60, 61, 64, 65, 68, 69, 72, 73, 76, 77, 80, 81, 84, 85, 88, 89, 92, 93, 96, 97, 100, 101, 104, 105, 108, 109, 112, 113, 116, 117, 120, 121, 124, 125, 128, 129, 132, 133, 136, 137, 140, 141, 144, 145, 148, 149, 152, 153, 156, 157, 160, 161, 164, 165, 168, 169, 172, 173, 176, 177, 180, 181, 184, 185, 188, 189, 192, 193, 196, 197, 200, 201, 204, 205, 208, 209, 212, 213, 216, 217, 220, 221, 224, 225, 228, 229, 232, 233, 236, 237, 240, 241, 244, 245, 248, 249, 252, 253, 256, 257, 260, 261, 264, 265, 268, 269, 272, 273, 276, 277, 280, 281, 284, 285, 288, 289, 292, 293, 296, 297, 300, 301, 304, 305, 308, 309, 312, 313, 316, 317, 320, 321, 324, 325, 328, 329, 332, 333, 336, 337, 340, 341, 344, 345, 348, 349, 352, 353, 356, 357, 360, 361, 364, 365, 368, 369, 372, 373, 376, 377, 380, 381, 384, 385, 388, 389, 392, 393, 396, 397, 400, 401, 404, 405, 408, 409, 412, 413, 416, 417, 420, 421, 424, 425, 428, 429, 432, 433, 436, 437, 440, 441, 444, 445, 448, 449, 452, 453, 456, 457, 460, 461, 464, 465, 468, 469, 472, 473, 476, 477, 480, 481, 484, 485, 488, 489, 492, 493, 496, 497, 500, 501, 504, 505, 508, 509, 512, 513, 516, 517, 520, 521, 524, 525, 528, 529, 532, 533, 536, 537, 540, 541, 544, 545, 548, 549, 552, 553, 556, 557, 560, 561, 564, 565, 568, 569, 572, 573, 576, 577, 580, 581, 584, 585, 588, 589, 592, 593, 596, 597,600, 601, 604, 605, 608, 609, 612, 613, 616, 617, 620, 621, 624, 625, 628, 629, 632, 633, 636, 637, 640, 641, 644, 645, 648, 649, 652, 653, 656, 657, 660, 661, 664, 665, 668, 669, 672, 673, 676, 677, 680, 681, 684, 685, 688, 689, 692, 693, 696, 697, 700, 701, 704, 705, 708, 709, 712, 713, 716, 717, 720, 721, 724, 725, 728, 729, 732, 733, 736, 737, 740, 741, 744, 745, 748, 749, 752, 753, 756, 757, 760, 761, 764, 765, 768, 769, 772, 773, 776, 777, 780, 781, 784, 785, 788, 789, 792, 793, 796, 797, 800, 801, 804, 805, 808, 809, 812, 813, 816, 817, 820, 821, 824, 825, 828, 829, 832, 833, 836, 837, 840, 841, 844, 845, 848, 849, 852, 853, 856, 857, 860, 861, 864, 865, 868, 869, 872, 873, 876, 877, 880, 881, 884, 885, 888, 889, 892, 893, 896, 897, 900, 901, 904, 905, 908, 909, 912, 913, 916, 917, 920, 921, 924, 925, 928, 929, 932, 933, 936, 937, 940, 941, 944, 945, 948, 949, 952, 953, 956, 957, 960, 961, 964, 965, 968, 969, 972, 973, 976, 977, 980, 981, 984, 985, 988, 989, 992, 993, 996, 997, 1000, 1001, 1004, 1005, 1008, 1009, 1012, 1013, 1016, 1017, 1020, 1021, 1024, 1025, 1028, 1029, 1032, 1033, 1036, 1037, 1040, 1041, 1044, 1045, 1048, 1049, 1052, 1053, 1056, 1057, 1060, 1061, 1064, 1065, 1068, 1069, 1072, 1073, 1076, 1077, 1080, 1081, 1084, 1085, 1088, 1089, 1092, 1093, 1096, 1097, 1100, 1101, 1104, 1105, 1108, 1109, 1112, 1113, 1116, 1117, 1120, 1121, 1124, 1125, 1128, 1129, 1132, 1133, 1136, 1137, 1140, 1141, 1144, 1145, 1148, 1149, 1152, 1153, 1156, 1157, 1160, 1161, 1164, 1165, 1168, 1169, 1172, 1173, 1176, 1177, 1180, 1181, 1184, 1185, 1188, 1189, 1192, 1193, 1196, 1197, 1200, 1201, 1204, 1205, 1208, 1209, 1212, 1213, 1216, 1217, 1220, 1221, 1224, 1225, 1228, 1229, 1232, 1233, 1236, 1237, 1240, 1241, 1244, 1245, 1248, 1249, 1252, 1253, 1256, 1257, 1260, 1261, 1264, 1265, 1268, 1269, 1272, 1273, 1276, 1277, 1280, 1281, 1284, 1285, 1288, 1289, 1292, 1293, 1296, 1297, 1300, 1301, 1304, 1305, 1308, 1309, 1312, 1313, 1316, 1317, 1320, 1321, 1324, 1325, 1328, 1329, 1332, 1333, 1336, 1337, 1340, 1341, 1344, 1345, 1348, 1349, 1352, 1353, 1356, 1357, 1360, 1361, 1364, 1365, 1368, 1369, 1372, 1373, 1376, 1377, 1380, 1381, 1384, 1385, 1388, 1389, 1392, 1393, 1396, 1397, 1400, 1401, 1404, 1405, 1408, 1409, 1412, 1413, 1416, 1417, 1420, 1421, 1424, 1425, 1428, 1429, 1432, 1433, 1436, 1437, 1440, 1441, 1444, 1445, 1448, 1449, 1452, 1453, 1456, 1457, 1460, 1461, 1464, 1465, 1468, 1469, 1472, 1473, 1476, 1477, 1480, 1481, 1484, 1485, 1488, 1489, 1492, 1493, 1496, 1497, 1500, 1501, 1504, 1505, 1508, 1509, 1512, 1513, 1516, 1517, 1520, 1521, 1524, 1525, 1528, 1529, 1532, 1533, 1536, 1537, 1540, 1541, 1544, 1545, 1548, 1549, 1552, 1553, 1556, 1557, 1560, 1561, 1564, 1565, 1568, 1569, 1572, 1573, 1576, 1577, 1580, 1581, 1584, 1585, 1588, 1589, 1592, 1593, 1596, 1597, 1600, 1601, 1604, 1605, 1608, 1609, 1612, 1613, 1616, 1617, 1620, 1621, 1624, 1625, 1628, 1629, 1632, 1633, 1636, 1637, 1640, 1641, 1644, 1645, 1648, 1649, 1652, 1653, 1656, 1657, 1660, 1661, 1664, 1665, 1668, 1669, 1672, 1673, 1676, 1677, 1680, 1681, 1684, 1685, 1688, 1689, 1692, 1693, 1696, 1697, 1700, 1701, 1704, 1705, 1708, 1709, 1712, 1713, 1716, 1717, 1720, 1721, 1724, 1725, 1728, 1729, 1732, 1733, 1736, 1737, 1740, 1741, 1744, 1745, 1748, 1749, 1752, 1753, 1756, 1757, 1760, 1761, 1764, 1765, 1768, 1769, 1772, 1773, 1776, 1777, 1780, 1781, 1784, 1785, 1788, 1789, 1792, 1793, 1796, 1797, 1800, 1801, 1804, 1805, 1808, 1809, 1812, 1813, 1816, 1817, 1820, 1821, 1824, 1825, 1828, 1829, 1832, 1833, 1836, 1837, 1840, 1841, 1844, 1845, 1848, 1849, 1852, 1853, 1856, 1857, 1860, 1861, 1864, 1865, 1868, 1869, 1872, 1873, 1876, 1877, 1880, 1881, 1884, 1885, 1888, 1889, 1892, 1893, 1896, 1897, 1900, 1901, 1904, 1905, 1908, 1909, 1912, 1913, 1916, 1917, 1920 or 1921, preferably any one of SEQ ID Nos: 36, 37, 56, 57, 60, 61, 144, 145, 160, 161, 252, 253, 264, 265, 284, 285, 288, 289, 392, 393, 400, 401, 428, 429, 472, 473, 480, 481, 496, 497, 504, 505, 524, 525, 568, 569, 576, 577, 588, 589, 608, 609, 620, 621, 628, 629, 656, 657, 668, 669, 680, 681, 696, 697, 700, 701, 724, 725, 732, 733, 744, 745, 780, 781, 804, 805, 824, 825, 832, 833, 844, 845, 848, 849, 860, 861, 864, 865, 868, 869, 872, 873, 876, 877, 880, 881, 888, 889, 908, 909, 916, 917, 948, 949, 956, 957, 972, 973, 980, 981, 1008, 1009, 1020, 1021, 1024, 1025, 1028, 1029, 1036, 1037, 1040, 1041, 1044, 1045, 1060, 1061, 1084, 1085,1088, 1089, 1104, 1105, 1120, 1121, 1128, 1129, 1144, 1145, 1148, 1149, 1152, 1153, 1156, 1157, 1160, 1161, 1184, 1185, 1188, 1189, 1192, 1193, 1212, 1213, 1216, 1217, 1256, 1257, 1272, 1273, 1276, 1277, 1280, 1281, 1284, 1285, 1296, 1297, 1300, 1301, 1304, 1305, 1312, 1313, 1332, 1333, 1336, 1337, 1348, 1349, 1356, 1357, 1360, 1361, 1364, 1365, 1368, 1369, 1604, 1605, 1616, 1617, 1620, 1621, 1628, 1629, 1632 or 1633.

11. The double-stranded oligonucleotide of any one of the preceding claims, wherein the sense strand has a nucleobase sequence comprising at least 15, at least 16, at least 17, at least 18, at least 19, at least 20 or at least 21 contiguous nucleobases, particularly 19, 20 or 21 contiguous nucleobases of any of the nucleobase sequences of any of SEQ ID NOs: 4, 5, 8, 9, 12, 13, 16, 17, 20, 21, 24, 25, 28, 29, 32, 33, 36, 37, 40, 41, 44, 45, 48, 49, 52, 53, 56, 57, 60, 61, 64, 65, 68, 69, 72, 73, 76, 77, 80, 81, 84, 85, 88, 89, 92, 93, 96, 97, 100, 101, 104, 105, 108, 109, 112, 113, 116, 117, 120, 121, 124, 125, 128, 129, 132, 133, 136, 137, 140, 141, 144, 145, 148, 149, 152, 153, 156, 157, 160, 161, 164, 165, 168, 169, 172, 173, 176, 177, 180, 181, 184, 185, 188, 189, 192, 193, 196, 197, 200, 201, 204, 205, 208, 209, 212, 213, 216, 217, 220, 221, 224, 225, 228, 229, 232, 233, 236, 237, 240, 241, 244, 245, 248, 249, 252, 253, 256, 257, 260, 261, 264, 265, 268, 269, 272, 273, 276, 277, 280, 281, 284, 285, 288, 289, 292, 293, 296, 297, 300, 301, 304, 305, 308, 309, 312, 313, 316, 317, 320, 321, 324, 325, 328, 329, 332, 333, 336, 337, 340, 341, 344, 345, 348, 349, 352, 353, 356, 357, 360, 361, 364, 365, 368, 369, 372, 373, 376, 377, 380, 381, 384, 385, 388, 389, 392, 393, 396, 397, 400, 401, 404, 405, 408, 409, 412, 413, 416, 417, 420, 421, 424, 425, 428, 429, 432, 433, 436, 437, 440, 441, 444, 445, 448, 449, 452, 453, 456, 457, 460, 461, 464, 465, 468, 469, 472, 473, 476, 477, 480, 481, 484, 485, 488, 489, 492, 493, 496, 497, 500, 501, 504, 505, 508, 509, 512, 513, 516, 517, 520, 521, 524, 525, 528, 529, 532, 533, 536, 537, 540, 541, 544, 545, 548, 549, 552, 553, 556, 557, 560, 561, 564, 565, 568, 569, 572, 573, 576, 577, 580, 581, 584, 585, 588, 589, 592, 593, 596, 597, 600, 601, 604, 605, 608, 609, 612, 613, 616, 617, 620, 621, 624, 625, 628, 629, 632, 633, 636, 637, 640, 641, 644, 645, 648, 649, 652, 653, 656, 657, 660, 661, 664, 665, 668, 669, 672, 673, 676, 677, 680, 681, 684, 685, 688, 689, 692, 693, 696, 697, 700, 701, 704, 705, 708, 709, 712, 713, 716, 717, 720, 721, 724, 725, 728, 729, 732, 733, 736, 737, 740, 741, 744, 745, 748, 749, 752, 753, 756, 757, 760, 761, 764, 765, 768, 769, 772, 773, 776, 777, 780, 781, 784, 785, 788, 789, 792, 793, 796, 797, 800, 801, 804, 805, 808, 809, 812, 813, 816, 817, 820, 821, 824, 825, 828, 829, 832, 833, 836, 837, 840, 841, 844, 845, 848, 849, 852, 853, 856, 857, 860, 861, 864, 865, 868, 869, 872, 873, 876, 877, 880, 881, 884, 885, 888, 889, 892, 893, 896, 897, 900, 901, 904, 905, 908, 909, 912, 913, 916, 917, 920, 921, 924, 925, 928, 929, 932, 933, 936, 937, 940, 941, 944, 945, 948, 949, 952, 953, 956, 957, 960, 961, 964, 965, 968, 969, 972, 973, 976, 977, 980, 981, 984, 985, 988, 989, 992, 993, 996, 997, 1000, 1001, 1004, 1005, 1008, 1009, 1012, 1013, 1016, 1017, 1020, 1021, 1024, 1025, 1028, 1029, 1032, 1033, 1036, 1037, 1040, 1041, 1044, 1045, 1048, 1049, 1052, 1053, 1056, 1057, 1060, 1061, 1064, 1065, 1068, 1069, 1072, 1073, 1076, 1077, 1080, 1081, 1084, 1085, 1088, 1089, 1092, 1093, 1096, 1097, 1100, 1101, 1104, 1105, 1108, 1109, 1112, 1113, 1116, 1117, 1120, 1121, 1124, 1125, 1128, 1129, 1132, 1133, 1136, 1137, 1140, 1141, 1144, 1145, 1148, 1149, 1152, 1153, 1156, 1157, 1160, 1161, 1164, 1165, 1168, 1169, 1172, 1173, 1176, 1177, 1180, 1181, 1184, 1185, 1188, 1189, 1192, 1193, 1196, 1197, 1200, 1201, 1204, 1205, 1208, 1209, 1212, 1213, 1216, 1217, 1220, 1221, 1224, 1225, 1228, 1229, 1232, 1233, 1236, 1237, 1240, 1241, 1244, 1245, 1248, 1249, 1252, 1253, 1256, 1257, 1260, 1261, 1264, 1265, 1268, 1269, 1272, 1273, 1276, 1277, 1280, 1281, 1284, 1285, 1288, 1289, 1292, 1293, 1296, 1297, 1300, 1301, 1304, 1305, 1308, 1309, 1312, 1313, 1316, 1317, 1320, 1321, 1324, 1325, 1328, 1329, 1332, 1333, 1336, 1337, 1340, 1341, 1344, 1345, 1348, 1349, 1352, 1353, 1356, 1357, 1360, 1361, 1364, 1365, 1368, 1369, 1372, 1373, 1376, 1377, 1380, 1381, 1384, 1385, 1388, 1389, 1392, 1393, 1396, 1397, 1400, 1401, 1404, 1405, 1408, 1409, 1412, 1413,1416, 1417, 1420, 1421, 1424, 1425, 1428, 1429, 1432, 1433, 1436, 1437, 1440, 1441, 1444, 1445, 1448, 1449, 1452, 1453, 1456, 1457, 1460, 1461, 1464, 1465, 1468, 1469, 1472, 1473, 1476, 1477, 1480, 1481, 1484, 1485, 1488, 1489, 1492, 1493, 1496, 1497, 1500, 1501, 1504, 1505, 1508, 1509, 1512, 1513, 1516, 1517, 1520, 1521, 1524, 1525, 1528, 1529, 1532, 1533, 1536, 1537, 1540, 1541, 1544, 1545, 1548, 1549, 1552, 1553, 1556, 1557, 1560, 1561, 1564, 1565, 1568, 1569, 1572, 1573, 1576, 1577, 1580, 1581, 1584, 1585, 1588, 1589, 1592, 1593, 1596, 1597, 1600, 1601, 1604, 1605, 1608, 1609, 1612, 1613, 1616, 1617, 1620, 1621, 1624, 1625, 1628, 1629, 1632, 1633, 1636, 1637, 1640, 1641, 1644, 1645, 1648, 1649, 1652, 1653, 1656, 1657, 1660, 1661, 1664, 1665, 1668, 1669, 1672, 1673, 1676, 1677, 1680, 1681, 1684, 1685, 1688, 1689, 1692, 1693, 1696, 1697, 1700, 1701, 1704, 1705, 1708, 1709, 1712, 1713, 1716, 1717, 1720, 1721, 1724, 1725, 1728, 1729, 1732, 1733, 1736, 1737, 1740, 1741, 1744, 1745, 1748, 1749, 1752, 1753, 1756, 1757, 1760, 1761, 1764, 1765, 1768, 1769, 1772, 1773, 1776, 1777, 1780, 1781, 1784, 1785, 1788, 1789, 1792, 1793, 1796, 1797, 1800, 1801, 1804, 1805, 1808, 1809, 1812, 1813, 1816, 1817, 1820, 1821, 1824, 1825, 1828, 1829, 1832, 1833, 1836, 1837, 1840, 1841, 1844, 1845, 1848, 1849, 1852, 1853, 1856, 1857, 1860, 1861, 1864, 1865, 1868, 1869, 1872, 1873, 1876, 1877, 1880, 1881, 1884, 1885, 1888, 1889, 1892, 1893, 1896, 1897, 1900, 1901, 1904, 1905, 1908, 1909, 1912, 1913, 1916, 1917, 1920 or 1921, preferably any one of SEQ ID Nos: 36, 37, 56, 57, 60, 61, 144, 145, 160, 161, 252, 253, 264, 265, 284, 285, 288, 289, 392, 393, 400, 401, 428, 429, 472, 473, 480, 481, 496, 497, 504, 505, 524, 525, 568, 569, 576, 577, 588, 589, 608, 609, 620, 621, 628, 629, 656, 657, 668, 669, 680, 681, 696, 697, 700, 701, 724, 725, 732, 733, 744, 745, 780, 781, 804, 805, 824, 825, 832, 833, 844, 845, 848, 849, 860, 861, 864, 865, 868, 869, 872, 873, 876, 877, 880, 881, 888, 889, 908, 909, 916, 917, 948, 949, 956, 957, 972, 973, 980, 981, 1008, 1009, 1020, 1021, 1024, 1025, 1028, 1029, 1036, 1037, 1040, 1041, 1044, 1045, 1060, 1061, 1084, 1085, 1088, 1089, 1104, 1105, 1120, 1121, 1128, 1129, 1144, 1145, 1148, 1149, 1152, 1153, 1156, 1157, 1160, 1161, 1184, 1185, 1188, 1189, 1192, 1193, 1212, 1213, 1216, 1217, 1256, 1257, 1272, 1273, 1276, 1277, 1280, 1281, 1284, 1285, 1296, 1297, 1300, 1301, 1304, 1305, 1312, 1313, 1332, 1333, 1336, 1337, 1348, 1349, 1356, 1357, 1360, 1361, 1364, 1365, 1368, 1369, 1604, 1605, 1616, 1617, 1620, 1621, 1628, 1629, 1632 or 1633.

12. The double-stranded oligonucleotide of any one of the preceding claims, wherein the nucleobase sequence of the sense strand comprises the nucleobase sequence of any of SEQ ID NOs: 4, 5, 8, 9, 12, 13, 16, 17, 20, 21, 24, 25, 28, 29, 32, 33, 36, 37, 40, 41, 44, 45, 48, 49, 52, 53, 56, 57, 60, 61, 64, 65, 68, 69, 72, 73, 76, 77, 80, 81, 84, 85, 88, 89, 92, 93, 96, 97, 100, 101, 104, 105, 108, 109, 112, 113, 116, 117, 120, 121, 124, 125, 128, 129, 132, 133, 136, 137, 140, 141, 144, 145, 148, 149, 152, 153, 156, 157, 160, 161, 164, 165, 168, 169, 172, 173, 176, 177, 180, 181, 184, 185, 188, 189, 192, 193, 196, 197, 200, 201, 204, 205, 208, 209, 212, 213, 216, 217, 220, 221, 224, 225, 228, 229, 232, 233, 236, 237, 240, 241, 244, 245, 248, 249, 252, 253, 256, 257, 260, 261, 264, 265, 268, 269, 272, 273, 276, 277, 280, 281, 284, 285, 288, 289, 292, 293, 296, 297, 300, 301, 304, 305, 308, 309, 312, 313, 316, 317, 320, 321, 324, 325, 328, 329, 332, 333, 336, 337, 340, 341, 344, 345, 348, 349, 352, 353, 356, 357, 360, 361, 364, 365, 368, 369, 372, 373, 376, 377, 380, 381, 384, 385, 388, 389, 392, 393, 396, 397, 400, 401, 404, 405, 408, 409, 412, 413, 416, 417, 420, 421, 424, 425, 428, 429, 432, 433, 436, 437, 440, 441, 444, 445, 448, 449, 452, 453, 456, 457, 460, 461, 464, 465, 468, 469, 472, 473, 476, 477, 480, 481, 484, 485, 488, 489, 492, 493, 496, 497, 500, 501, 504, 505, 508, 509, 512, 513, 516, 517, 520, 521, 524, 525, 528, 529, 532, 533, 536, 537, 540, 541, 544, 545, 548, 549, 552, 553, 556, 557, 560, 561, 564, 565, 568, 569, 572, 573, 576, 577, 580, 581, 584, 585, 588, 589, 592, 593, 596, 597, 600, 601, 604, 605, 608, 609, 612, 613, 616, 617, 620, 621, 624, 625, 628, 629, 632, 633, 636, 637, 640, 641, 644, 645, 648, 649, 652, 653, 656, 657, 660, 661, 664, 665, 668, 669, 672, 673, 676,677, 680, 681, 684, 685, 688, 689, 692, 693, 696, 697, 700, 701, 704, 705, 708, 709, 712, 713, 716, 717, 720, 721, 724, 725, 728, 729, 732, 733, 736, 737, 740, 741, 744, 745, 748, 749, 752, 753, 756, 757, 760, 761, 764, 765, 768, 769, 772, 773, 776, 777, 780, 781, 784, 785, 788, 789, 792, 793, 796, 797, 800, 801, 804, 805, 808, 809, 812, 813, 816, 817, 820, 821, 824, 825, 828, 829, 832, 833, 836, 837, 840, 841, 844, 845, 848, 849, 852, 853, 856, 857, 860, 861, 864, 865, 868, 869, 872, 873, 876, 877, 880, 881, 884, 885, 888, 889, 892, 893, 896, 897, 900, 901, 904, 905, 908, 909, 912, 913, 916, 917, 920, 921, 924, 925, 928, 929, 932, 933, 936, 937, 940, 941, 944, 945, 948, 949, 952, 953, 956, 957, 960, 961, 964, 965, 968, 969, 972, 973, 976, 977, 980, 981, 984, 985, 988, 989, 992, 993, 996, 997, 1000, 1001, 1004, 1005, 1008, 1009, 1012, 1013, 1016, 1017, 1020, 1021, 1024, 1025, 1028, 1029, 1032, 1033, 1036, 1037, 1040, 1041, 1044, 1045, 1048, 1049, 1052, 1053, 1056, 1057, 1060, 1061, 1064, 1065, 1068, 1069, 1072, 1073, 1076, 1077, 1080, 1081, 1084, 1085, 1088, 1089, 1092, 1093, 1096, 1097, 1100, 1101, 1104, 1105, 1108, 1109, 1112, 1113, 1116, 1117, 1120, 1121, 1124, 1125, 1128, 1129, 1132, 1133, 1136, 1137, 1140, 1141, 1144, 1145, 1148, 1149, 1152, 1153, 1156, 1157, 1160, 1161, 1164, 1165, 1168, 1169, 1172, 1173, 1176, 1177, 1180, 1181, 1184, 1185, 1188, 1189, 1192, 1193, 1196, 1197, 1200, 1201, 1204, 1205, 1208, 1209, 1212, 1213, 1216, 1217, 1220, 1221, 1224, 1225, 1228, 1229, 1232, 1233, 1236, 1237, 1240, 1241, 1244, 1245, 1248, 1249, 1252, 1253, 1256, 1257, 1260, 1261, 1264, 1265, 1268, 1269, 1272, 1273, 1276, 1277, 1280, 1281, 1284, 1285, 1288, 1289, 1292, 1293, 1296, 1297, 1300, 1301, 1304, 1305, 1308, 1309, 1312, 1313, 1316, 1317, 1320, 1321, 1324, 1325, 1328, 1329, 1332, 1333, 1336, 1337, 1340, 1341, 1344, 1345, 1348, 1349, 1352, 1353, 1356, 1357, 1360, 1361, 1364, 1365, 1368, 1369, 1372, 1373, 1376, 1377, 1380, 1381, 1384, 1385, 1388, 1389, 1392, 1393, 1396, 1397, 1400, 1401, 1404, 1405, 1408, 1409, 1412, 1413, 1416, 1417, 1420, 1421, 1424, 1425, 1428, 1429, 1432, 1433, 1436, 1437, 1440, 1441, 1444, 1445, 1448, 1449, 1452, 1453, 1456, 1457, 1460, 1461, 1464, 1465, 1468, 1469, 1472, 1473, 1476, 1477, 1480, 1481, 1484, 1485, 1488, 1489, 1492, 1493, 1496, 1497, 1500, 1501, 1504, 1505, 1508, 1509, 1512, 1513, 1516, 1517, 1520, 1521, 1524, 1525, 1528, 1529, 1532, 1533, 1536, 1537, 1540, 1541, 1544, 1545, 1548, 1549, 1552, 1553, 1556, 1557, 1560, 1561, 1564, 1565, 1568, 1569, 1572, 1573, 1576, 1577, 1580, 1581, 1584, 1585, 1588, 1589, 1592, 1593, 1596, 1597, 1600, 1601, 1604, 1605, 1608, 1609, 1612, 1613, 1616, 1617, 1620, 1621, 1624, 1625, 1628, 1629, 1632, 1633, 1636, 1637, 1640, 1641, 1644, 1645, 1648, 1649, 1652, 1653, 1656, 1657, 1660, 1661, 1664, 1665, 1668, 1669, 1672, 1673, 1676, 1677, 1680, 1681, 1684, 1685, 1688, 1689, 1692, 1693, 1696, 1697, 1700, 1701, 1704, 1705, 1708, 1709, 1712, 1713, 1716, 1717, 1720, 1721, 1724, 1725, 1728, 1729, 1732, 1733, 1736, 1737, 1740, 1741, 1744, 1745, 1748, 1749, 1752, 1753, 1756, 1757, 1760, 1761, 1764, 1765, 1768, 1769, 1772, 1773, 1776, 1777, 1780, 1781, 1784, 1785, 1788, 1789, 1792, 1793, 1796, 1797, 1800, 1801, 1804, 1805, 1808, 1809, 1812, 1813, 1816, 1817, 1820, 1821, 1824, 1825, 1828, 1829, 1832, 1833, 1836, 1837, 1840, 1841, 1844, 1845, 1848, 1849, 1852, 1853, 1856, 1857, 1860, 1861, 1864, 1865, 1868, 1869, 1872, 1873, 1876, 1877, 1880, 1881, 1884, 1885, 1888, 1889, 1892, 1893, 1896, 1897, 1900, 1901, 1904, 1905, 1908, 1909, 1912, 1913, 1916, 1917, 1920 or 1921, preferably any one of SEQ ID Nos: 36, 37, 56, 57, 60, 61, 144, 145, 160, 161, 252, 253, 264, 265, 284, 285, 288, 289, 392, 393, 400, 401, 428, 429, 472, 473, 480, 481, 496, 497, 504, 505, 524, 525, 568, 569, 576, 577, 588, 589, 608, 609, 620, 621, 628, 629, 656, 657, 668, 669, 680, 681, 696, 697, 700, 701, 724, 725, 732, 733, 744, 745, 780, 781, 804, 805, 824, 825, 832, 833, 844, 845, 848, 849, 860, 861, 864, 865, 868, 869, 872, 873, 876, 877, 880, 881, 888, 889, 908, 909, 916, 917, 948, 949, 956, 957, 972, 973, 980, 981, 1008, 1009, 1020, 1021, 1024, 1025, 1028, 1029, 1036, 1037, 1040, 1041, 1044, 1045, 1060, 1061, 1084, 1085, 1088, 1089, 1104, 1105, 1120, 1121, 1128, 1129, 1144, 1145, 1148, 1149, 1152, 1153, 1156, 1157, 1160, 1161, 1184, 1185, 1188, 1189, 1192, 1193, 1212, 1213, 1216, 1217, 1256, 1257,1272, 1273, 1276, 1277, 1280, 1281, 1284, 1285, 1296, 1297, 1300, 1301, 1304, 1305, 1312, 1313, 1332, 1333, 1336, 1337, 1348, 1349, 1356, 1357, 1360, 1361, 1364, 1365, 1368, 1369, 1604, 1605, 1616, 1617, 1620, 1621, 1628, 1629, 1632 or 1633.

13. The double-stranded oligonucleotide of any one of the preceding claims, wherein the nucleobase sequence of the sense strand consists of the nucleobase sequence of any of SEQ ID NOs: 4, 5, 8, 9, 12, 13, 16, 17, 20, 21, 24, 25, 28, 29, 32, 33, 36, 37, 40, 41, 44, 45, 48, 49, 52, 53, 56, 57, 60, 61, 64, 65, 68, 69, 72, 73, 76, 77, 80, 81, 84, 85, 88, 89, 92, 93, 96, 97, 100, 101, 104, 105, 108, 109, 112, 113, 116, 117, 120, 121, 124, 125, 128, 129, 132, 133, 136, 137, 140, 141, 144, 145, 148, 149, 152, 153, 156, 157, 160, 161, 164, 165, 168, 169, 172, 173, 176, 177, 180, 181, 184, 185, 188, 189, 192, 193, 196, 197, 200, 201, 204, 205, 208, 209, 212, 213, 216, 217, 220, 221, 224, 225, 228, 229, 232, 233, 236, 237, 240, 241, 244, 245, 248, 249, 252, 253, 256, 257, 260, 261, 264, 265, 268, 269, 272, 273, 276, 277, 280, 281, 284, 285, 288, 289, 292, 293, 296, 297, 300, 301, 304, 305, 308, 309, 312, 313, 316, 317, 320, 321, 324, 325, 328, 329, 332, 333, 336, 337, 340, 341, 344, 345, 348, 349, 352, 353, 356, 357, 360, 361, 364, 365, 368, 369, 372, 373, 376, 377, 380, 381, 384, 385, 388, 389, 392, 393, 396, 397, 400, 401, 404, 405, 408, 409, 412, 413, 416, 417, 420, 421, 424, 425, 428, 429, 432, 433, 436, 437, 440, 441, 444, 445, 448, 449, 452, 453, 456, 457, 460, 461, 464, 465, 468, 469, 472, 473, 476, 477, 480, 481, 484, 485, 488, 489, 492, 493, 496, 497, 500, 501, 504, 505, 508, 509, 512, 513, 516, 517, 520, 521, 524, 525, 528, 529, 532, 533, 536, 537, 540, 541, 544, 545, 548, 549, 552, 553, 556, 557, 560, 561, 564, 565, 568, 569, 572, 573, 576, 577, 580, 581, 584, 585, 588, 589, 592, 593, 596, 597, 600, 601, 604, 605, 608, 609, 612, 613, 616, 617, 620, 621, 624, 625, 628, 629, 632, 633, 636, 637, 640, 641, 644, 645, 648, 649, 652, 653, 656, 657, 660, 661, 664, 665, 668, 669, 672, 673, 676, 677, 680, 681, 684, 685, 688, 689, 692, 693, 696, 697, 700, 701, 704, 705, 708, 709, 712, 713, 716, 717, 720, 721, 724, 725, 728, 729, 732, 733, 736, 737, 740, 741, 744, 745, 748, 749, 752, 753, 756, 757, 760, 761, 764, 765, 768, 769, 772, 773, 776, 777, 780, 781, 784, 785, 788, 789, 792, 793, 796, 797, 800, 801, 804, 805, 808, 809, 812, 813, 816, 817, 820, 821, 824, 825, 828, 829, 832, 833, 836, 837, 840, 841, 844, 845, 848, 849, 852, 853, 856, 857, 860, 861, 864, 865, 868, 869, 872, 873, 876, 877, 880, 881, 884, 885, 888, 889, 892, 893, 896, 897, 900, 901, 904, 905, 908, 909, 912, 913, 916, 917, 920, 921, 924, 925, 928, 929, 932, 933, 936, 937, 940, 941, 944, 945, 948, 949, 952, 953, 956, 957, 960, 961, 964, 965, 968, 969, 972, 973, 976, 977, 980, 981, 984, 985, 988, 989, 992, 993, 996, 997, 1000, 1001, 1004, 1005, 1008, 1009, 1012, 1013, 1016, 1017, 1020, 1021, 1024, 1025, 1028, 1029, 1032, 1033, 1036, 1037, 1040, 1041, 1044, 1045, 1048, 1049, 1052, 1053, 1056, 1057, 1060, 1061, 1064, 1065, 1068, 1069, 1072, 1073, 1076, 1077, 1080, 1081, 1084, 1085, 1088, 1089, 1092, 1093, 1096, 1097, 1100, 1101, 1104, 1105, 1108, 1109, 1112, 1113, 1116, 1117, 1120, 1121, 1124, 1125, 1128, 1129, 1132, 1133, 1136, 1137, 1140, 1141, 1144, 1145, 1148, 1149, 1152, 1153, 1156, 1157, 1160, 1161, 1164, 1165, 1168, 1169, 1172, 1173, 1176, 1177, 1180, 1181, 1184, 1185, 1188, 1189, 1192, 1193, 1196, 1197, 1200, 1201, 1204, 1205, 1208, 1209, 1212, 1213, 1216, 1217, 1220, 1221, 1224, 1225, 1228, 1229, 1232, 1233, 1236, 1237, 1240, 1241, 1244, 1245, 1248, 1249, 1252, 1253, 1256, 1257, 1260, 1261, 1264, 1265, 1268, 1269, 1272, 1273, 1276, 1277, 1280, 1281, 1284, 1285, 1288, 1289, 1292, 1293, 1296, 1297, 1300, 1301, 1304, 1305, 1308, 1309, 1312, 1313, 1316, 1317, 1320, 1321, 1324, 1325, 1328, 1329, 1332, 1333, 1336, 1337, 1340, 1341, 1344, 1345, 1348, 1349, 1352, 1353, 1356, 1357, 1360, 1361, 1364, 1365, 1368, 1369, 1372, 1373, 1376, 1377, 1380, 1381, 1384, 1385, 1388, 1389, 1392, 1393, 1396, 1397, 1400, 1401, 1404, 1405, 1408, 1409, 1412, 1413, 1416, 1417, 1420, 1421, 1424, 1425, 1428, 1429, 1432, 1433, 1436, 1437, 1440, 1441, 1444, 1445, 1448, 1449, 1452, 1453, 1456, 1457, 1460, 1461, 1464,1465, 1468, 1469, 1472, 1473, 1476, 1477, 1480, 1481, 1484, 1485, 1488, 1489, 1492, 1493, 1496, 1497, 1500, 1501, 1504, 1505, 1508, 1509, 1512, 1513, 1516, 1517, 1520, 1521, 1524, 1525, 1528, 1529, 1532, 1533, 1536, 1537, 1540, 1541, 1544, 1545, 1548, 1549, 1552, 1553, 1556, 1557, 1560, 1561, 1564, 1565, 1568, 1569, 1572, 1573, 1576, 1577, 1580, 1581, 1584, 1585, 1588, 1589, 1592, 1593, 1596, 1597, 1600, 1601, 1604, 1605, 1608, 1609, 1612, 1613, 1616, 1617, 1620, 1621, 1624, 1625, 1628, 1629, 1632, 1633, 1636, 1637, 1640, 1641, 1644, 1645, 1648, 1649, 1652, 1653, 1656, 1657, 1660, 1661, 1664, 1665, 1668, 1669, 1672, 1673, 1676, 1677, 1680, 1681, 1684, 1685, 1688, 1689, 1692, 1693, 1696, 1697, 1700, 1701, 1704, 1705, 1708, 1709, 1712, 1713, 1716, 1717, 1720, 1721, 1724, 1725, 1728, 1729, 1732, 1733, 1736, 1737, 1740, 1741, 1744, 1745, 1748, 1749, 1752, 1753, 1756, 1757, 1760, 1761, 1764, 1765, 1768, 1769, 1772, 1773, 1776, 1777, 1780, 1781, 1784, 1785, 1788, 1789, 1792, 1793, 1796, 1797, 1800, 1801, 1804, 1805, 1808, 1809, 1812, 1813, 1816, 1817, 1820, 1821, 1824, 1825, 1828, 1829, 1832, 1833, 1836, 1837, 1840, 1841, 1844, 1845, 1848, 1849, 1852, 1853, 1856, 1857, 1860, 1861, 1864, 1865, 1868, 1869, 1872, 1873, 1876, 1877, 1880, 1881, 1884, 1885, 1888, 1889, 1892, 1893, 1896, 1897, 1900, 1901, 1904, 1905, 1908, 1909, 1912, 1913, 1916, 1917, 1920 or 1921, preferably any one of SEQ ID Nos: 36, 37, 56, 57, 60, 61, 144, 145, 160, 161, 252, 253, 264, 265, 284, 285, 288, 289, 392, 393, 400, 401, 428, 429, 472, 473, 480, 481, 496, 497, 504, 505, 524, 525, 568, 569, 576, 577, 588, 589, 608, 609, 620, 621, 628, 629, 656, 657, 668, 669, 680, 681, 696, 697, 700, 701, 724, 725, 732, 733, 744, 745, 780, 781, 804, 805, 824, 825, 832, 833, 844, 845, 848, 849, 860, 861, 864, 865, 868, 869, 872, 873, 876, 877, 880, 881, 888, 889, 908, 909, 916, 917, 948, 949, 956, 957, 972, 973, 980, 981, 1008, 1009, 1020, 1021, 1024, 1025, 1028, 1029, 1036, 1037, 1040, 1041, 1044, 1045, 1060, 1061, 1084, 1085, 1088, 1089, 1104, 1105, 1120, 1121, 1128, 1129, 1144, 1145, 1148, 1149, 1152, 1153, 1156, 1157, 1160, 1161, 1184, 1185, 1188, 1189, 1192, 1193, 1212, 1213, 1216, 1217, 1256, 1257, 1272, 1273, 1276, 1277, 1280, 1281, 1284, 1285, 1296, 1297, 1300, 1301, 1304, 1305, 1312, 1313, 1332, 1333, 1336, 1337, 1348, 1349, 1356, 1357, 1360, 1361, 1364, 1365, 1368, 1369, 1604, 1605, 1616, 1617, 1620, 1621, 1628, 1629, 1632 or 1633.

14. The double-stranded oligonucleotide of any one of the preceding claims, wherein: (a) the nucleobase sequence of the antisense strand consists of between 10 to 25, 10 to 30, 12 to 25, 13 to 25, 14 to 25, 15 to 25, 16 to 25, 17 to 25, 18 to 25, 19 to 25, 20 to 25, 21 to 25, 22 to 25, 23 to 25, 19 to 24, 20 to 24, 21 to 24, 22 to 24, 19 to 23, 20 to 23, 21 to 23, 19 to 22, 20 to 22 or 19 to 21 linked nucleosides, preferably of between 19 to 23 linked nucleosides; and / or (b) the nucleobase sequence of the sense strand consists of between 10 to 25, 10 to 30, 12 to 25, 13 to 25, 14 to 25, 15 to 25, 16 to 25, 17 to 25, 18 to 25, 19 to 25, 20 to 25, 21 to 25, 22 to 25, 23 to 25, 19 to 24, 20 to 24, 21 to 24, 22 to 24, 19 to 23, 20 to 23, 21 to 23, 19 to 22, 20 to 22 or 19 to 21 linked nucleosides, preferably of between 19 to 23 linked nucleosides.

15. The double-stranded oligonucleotide of any one of the preceding claims, wherein the nucleobase sequence of the antisense strand consists of between 19 to 23 linked nucleosides and the nucleobase sequence of the sense strand consists of between 19 to 23 linked nucleosides, preferably wherein the nucleobase sequence of the antisense strand consists of between 19 to 23 linked nucleosides and the nucleobase sequence of the sense strand consists of between 19 to 21 linked nucleosides.

16. The double-stranded oligonucleotide of any one of the preceding claims, wherein the 3’ end of the antisense strand overhangs the sense strand by between about 0 to about 6 nucleosides, preferably by about 2 nucleosides.

17. The double-stranded oligonucleotide of any one of the preceding claims, wherein the antisense strand and / or the sense strand, preferably both the antisense strand and the sense strand, comprise at least one modification optionally selected from a modified sugar moiety and / or a modified internucleoside linkage.

18. The double-stranded oligonucleotide of claim 17, wherein the antisense strand and / or the sense, preferably both the antisense strand and the sense strand, comprise comprises at least one modified sugar moiety.

19. The double-stranded oligonucleotide of claim 17 or 18, wherein the modified sugar moiety comprises a non-bicyclic sugar moiety.

20. The double-stranded oligonucleotide of claim 19, wherein the non-bicyclic modified sugar moiety is a 2’-OMe modified sugar moiety and / or a 2’-fluoro modified sugar moiety.

21. The double-stranded oligonucleotide of any one of the preceding claims, wherein the antisense strand and / or the sense strand, preferably both the antisense strand and the sense strand, comprises at least one modified internucleoside linkage.

22. The double-stranded oligonucleotide of claim 22, wherein the at least one modified internucleoside linkage is a phosphorothioate internucleoside linkage.

23. The double-stranded oligonucleotide of any one of the preceding claims, the antisense strand and / or the sense strand, preferably both the antisense strand and the sense strand, comprise at least one phosphodiester internucleoside linkage.

24. The double-stranded oligonucleotide of any one of the preceding claims, wherein each internucleoside linkage of the antisense strand and / or the sense strand, preferably both the antisense strand and the sense strand, is independently selected from a phosphodiester or a phosphorothioate internucleoside linkage.

25. The double-stranded oligonucleotide of any one of the preceding claims, wherein: (a) at least 1, at least 2, at least 3, at least 4, at least 5 or more of the internucleoside linkages of the antisense strand are phosphorothioate internucleoside linkages, preferably wherein 4 of the internucleoside linkages of the antisense are phosphorothioate internucleoside linkages; and / or (b) at least 1, at least 2, at least 3, at least 4, at least 5 or more of the internucleoside linkages of the sense strand are phosphorothioate internucleoside linkages, preferably wherein 4 of the internucleoside linkages of the sense strand are phosphorothioate internucleoside linkages; wherein preferably 4 of the internucleoside linkages of the sense strand and 4 of the internucleoside linkages of the antisense strand are phosphorothioate internucleoside linkages.

26. The double-stranded oligonucleotide of any one of claims 21-25, wherein: (a) the antisense strand comprises at least two consecutive modified internucleoside linkages at the 5’ end; and / or (b) the antisense strand comprises at least two consecutive modified internucleoside linkages at the 3’ end.

27. The double-stranded oligonucleotide of any one of claims 21-26, wherein: (a) the sense strand comprises at least two consecutive modified internucleoside linkages at the 5’ end; and / or (b) the sense strand comprises at least two consecutive modified internucleoside linkages at the 3’ end.

28. The double-stranded oligonucleotide of any one of the preceding claims, wherein the antisense strand comprises: (a) 5’[mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mR N][fRN][mRN][fRN][mRN]3’; (b) 5’[mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][mRN][mRN][fRN][mR N][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN]3’; (c) 5’[mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][mRN][mRN][fRN][mR N][fRN][mRN][fRN][mRN][fRN][mRN][mRN][mRN]3’; (d) 5’[mRN][fRN][mRN][mRN][mRN][fRN][mRN][fRN][fRN][mRN][mRN][mRN][mRN][fRN][m RN][fRN][mRN][mRN][mRN][mRN][mRN][mRN][mRN]3’; (e) 5’[mRN][fRN][mRN][mRN][mRN][fRN][mRN][mRN][mRN][mRN][mRN][mRN][mRN][fRN][ mRN][fRN][mRN][mRN][mRN][mRN][mRN][mRN][mRN]3’; or (f) 5’[mRN][fRN][mRN][mRN][mRN][modN][modN][modN][fRN][mRN][mRN][mRN][mRN][fR N][mRN][fRN][mRN][mRN][mRN][mRN][mRN][mRN][mRN]3’; wherein [mRN] stands for a 2’-O-methyl modified nucleotide, [fRN] stands for a 2’-fluoro modified nucleotide and [modN] stands for a modified nucleotide; wherein each [modN] may be independently selected from any xeno nucleic acid (XNA) a 2’-O-methyl modified nucleotide or a 2’-fluoro modified nucleotide; and wherein preferably the [modR] at position 7 is modified, more preferably wherein the [modR] at position 7 is an XNA.

29. The double-stranded oligonucleotide of claim 28, wherein in the antisense strand the two 5’ most internucleoside linkages are phosphorothioate internucleoside linkages and the two 3’ most internucleoside linkages are phosphorothioate internucleoside linkages.

30. The double-stranded oligonucleotide of any one of the preceding claims, wherein the sense strand comprises: (a) 5’[mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mR N][fRN][mRN][fRN][mRN]3’; (b) 5’[fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][fRN][fRN][mRN][fRN][mRN][fRN][ mRN][fRN][mRN][fRN][mRN][fRN]3’; (c) 5’[mRN][mRN][mRN][mRN][mRN][mRN][fRN][fRN][fRN][mRN][mRN][mRN][mRN][mRN][ mRN][mRN][mRN][mRN][mRN]3’; or (d) 5’[mRN][mRN][mRN][mRN][mRN][mRN][fRN][mRN][fRN][fRN][fRN][mRN][mRN][mRN][ mRN][mRN][mRN][mRN][mRN][mRN][mRN]3’; wherein [mRN] stands for a 2’-O-methyl modified nucleotide and [fRN] stands for a 2’-fluoro modified nucleotide.

31. The double-stranded oligonucleotide of claim 30, wherein in the sense strand the two 5’ most internucleoside linkages are phosphorothioate internucleoside linkages and the two 3’ most internucleoside linkages are phosphorothioate internucleoside linkages.

32. The double-stranded oligonucleotide of any one of the preceding claims, wherein: (a) the antisense strand comprises 5’[mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mR N][fRN][mRN][fRN][mRN]3’; and (b) the sense strand comprises 5’[mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mR N][fRN][mRN][fRN][mRN]3’; wherein [mRN] stands for a 2’-O-methyl modified nucleotide and [fRN] stands for a 2’-fluoro modified nucleotide.

33. The double-stranded oligonucleotide of claim 32, wherein in both the antisense strand and the sense strand the two 5’ most internucleoside linkages are phosphorothioate internucleoside linkages and the two 3’ most internucleoside linkages are phosphorothioate internucleoside linkages.

34. The double-stranded oligonucleotide of any one of claims 1-31, wherein:(a) the antisense strand comprises 5’[mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][mRN][mRN][fRN][mR N][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN]3’; and (b) the sense strand comprises 5’[fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][fRN][fRN][mRN][fRN][mRN][fRN][ mRN][fRN][mRN][fRN][mRN][fRN]3’; wherein [mRN] stands for a 2’-O-methyl modified nucleotide and [fRN] stands for a 2’-fluoro modified nucleotide.

35. The double-stranded oligonucleotide of claim 34, wherein in both the antisense strand and the sense strand the two 5’ most internucleoside linkages are phosphorothioate internucleoside linkages and the two 3’ most internucleoside linkages are phosphorothioate internucleoside linkages.

36. The double-stranded oligonucleotide of any one of claims 1-31, wherein: (c) the antisense strand comprises 5’mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN ][fRN][mRN][fRN][mRN]3’; and (d) the sense strand comprises 5’[mRN][mRN][mRN][mRN][mRN][mRN][fRN][fRN][fRN][mRN][mRN][mRN][mRN][mRN][ mRN][mRN][mRN][mRN][mRN]3’; wherein [mRN] stands for a 2’-O-methyl modified nucleotide and [fRN] stands for a 2’-fluoro modified nucleotide.

37. The double-stranded oligonucleotide of claim 36, wherein in both the antisense strand and the sense strand the two 5’ most internucleoside linkages are phosphorothioate internucleoside linkages and the two 3’ most internucleoside linkages are phosphorothioate internucleoside linkages.

38. The double-stranded oligonucleotide of any one of claims 1-31, wherein: (a) the antisense strand comprises 5’[mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][fRN][mRN][mRN][mRN][fRN][mR N][fRN][mRN][fRN][mRN][fRN][mRN][mRN][mRN]3’; and (e) the sense strand comprises 5’[mRN][mRN][mRN][mRN][mRN][mRN][fRN][mRN][fRN][fRN][fRN][mRN][mRN][mRN][ mRN][mRN][mRN][mRN][mRN][mRN][mRN]3’;wherein [mRN] stands for a 2’-O-methyl modified nucleotide and [fRN] stands for a 2’-fluoro modified nucleotide.

39. The double-stranded oligonucleotide of claim 38, wherein in both the antisense strand and the sense strand the two 5’ most internucleoside linkages are phosphorothioate internucleoside linkages and the two 3’ most internucleoside linkages are phosphorothioate internucleoside linkages.

40. The double-stranded oligonucleotide of any one of claims 1-31, wherein: (a) the antisense strand comprises 5’[mRN][fRN][mRN][mRN][mRN][fRN][mRN][fRN][fRN][mRN][mRN][mRN][mRN][fRN][m RN][fRN][mRN][mRN][mRN][mRN][mRN][mRN][mRN]3’; and (b) the sense strand comprises 5’[mRN][mRN][mRN][mRN][mRN][mRN][fRN][mRN][fRN][fRN][fRN][mRN][mRN][mRN][ mRN][mRN][mRN][mRN][mRN][mRN][mRN]3’; wherein [mRN] stands for a 2’-O-methyl modified nucleotide and [fRN] stands for a 2’-fluoro modified nucleotide.

41. The double-stranded oligonucleotide of claim 40, wherein in both the antisense strand and the sense strand the two 5’ most internucleoside linkages are phosphorothioate internucleoside linkages and the two 3’ most internucleoside linkages are phosphorothioate internucleoside linkages.

42. The double-stranded oligonucleotide of any one of claims 1-31, wherein: (a) the antisense strand comprises 5’[mRN][fRN][mRN][mRN][mRN][fRN][mRN][mRN][mRN][mRN][mRN][mRN][mRN][fRN][ mRN][fRN][mRN][mRN][mRN][mRN][mRN][mRN][mRN]3’; and (b) the sense strand comprises 5’[mRN][mRN][mRN][mRN][mRN][mRN][fRN][mRN][fRN][fRN][fRN][mRN][mRN][mRN][ mRN][mRN][mRN][mRN][mRN][mRN][mRN]3’; wherein [mRN] stands for a 2’-O-methyl modified nucleotide and [fRN] stands for a 2’-fluoro modified nucleotide.

43. The double-stranded oligonucleotide of claim 42, wherein in both the antisense strand and the sense strand the two 5’ most internucleoside linkages are phosphorothioate internucleoside linkages and the two 3’ most internucleoside linkages are phosphorothioate internucleoside linkages.

44. The double-stranded oligonucleotide of claim any one of the preceding claims, wherein the antisense strand comprises a 5’ 5-vinylphosphonate (5VP) modification.

45. The double-stranded oligonucleotide of any one of the preceding claims, wherein the antisense strand and / or the sense strand comprises at least one modified nucleobase, optionally selected from 5- methylcytosine or methyl-uracil.

46. A polynucleotide conjugate comprising a double-stranded oligonucleotide of any one of the preceding claims and a conjugate group.

47. The polynucleotide conjugate of claim 46, wherein the conjugate group comprises a conjugate linker and a conjugate moiety.

48. The polynucleotide conjugate of claim 46 or 47, wherein the conjugate linker consists of a single bond.

49. The polynucleotide conjugate of any of claims 46-48, wherein the conjugate linker is cleavable.

50. The polynucleotide conjugate of any of claims 46-49, wherein the conjugate linker comprises 1-3 linker-nucleosides.

51. The polynucleotide conjugate of any of claims 46-50, wherein the conjugate linker is a phosphate.

52. The polynucleotide conjugate of any of claims 46-51, wherein the conjugate group is attached to the modified oligonucleotide at the 5’-end of the modified oligonucleotide.

53. The polynucleotide conjugate of any of claims 46-52, wherein the conjugate group is attached to the modified oligonucleotide at the 3’-end of the modified oligonucleotide.

54. The polynucleotide conjugate of any of claims 46-53, wherein the conjugate group comprises N-acetyl galactosamine (GalNAc).

55. The polynucleotide conjugate of claim 54, wherein the GalNAc is present at the 5’ and / or the 3’ of (i) the antisense strand and / or (ii) the sense strand, wherein preferably the GalNAc is present at the 5’ and / or 3’ end of the sense strand, more preferably at the 3’ end of the sense strand.

56. The polynucleotide conjugate of claim 54 or 55, wherein the conjugate group has the following structure:.

57. A double-stranded oligonucleotide conjugate wherein the conjugate group has the following structure:wherein the conjugate group is present at the 5’ and / or the 3’ of (i) the antisense strand and / or (ii) the sense strand, wherein preferably the conjugate group is present at the 5’ and / or 3’ end of the sense strand, more preferably at the 3’ end of the sense strand, and wherein the double-stranded oligonucleotide is selected from Compound 98 (SEQ ID NO 391; SEQ ID NO 393), 126 (SEQ ID NO 503; SEQ ID NO 505), 195 (SEQ ID NO 779; SEQ ID NO 781), 211 (SEQ ID NO 843; SEQ ID NO 845), 219 (SEQ ID NO 875; SEQ ID NO 877), 271 (SEQ ID NO 1083; SEQ ID NO 1085), 297 (SEQ ID NO 1187; SEQ ID NO 1189) or 324 (SEQ ID NO 1295; SEQ ID NO 1297).

58. The polynucleotide conjugate of any of claims 46-56, wherein the conjugate group comprises a cell-targeting moiety.

59. The polynucleotide conjugate of any of claims 46-56, or 58, which comprises a terminal group.

60. The polynucleotide conjugate of claim 59, wherein the terminal group is an abasic sugar moiety.

61. A chirally enriched population of double-stranded oligonucleotide as defined in any one of claims 1-45, or the polynucleotide conjugates as defined in any of claims 46-60, wherein the population is enriched for double-stranded oligonucleotides comprising at least one particular phosphorothioate internucleoside linkage having a particular stereochemical configuration, or polynucleotide conjugates comprising said double-stranded oligonucleotides.

62. The chirally enriched population of claim 61, wherein the population is enriched for double- stranded oligonucleotides comprising at least one particular phosphorothioate internucleoside linkage having the (Sp) or (Rp) configuration, or polynucleotide conjugates comprising said double-stranded oligonucleotides.

63. The chirally enriched population of claim 61, wherein the population is enriched for double- stranded oligonucleotides having a particular, independently selected stereochemical configuration at each phosphorothioate internucleoside linkage, or polynucleotide conjugates comprising said double-stranded oligonucleotides.

64. The chirally enriched population of claim 61, wherein the population is enriched for double- stranded oligonucleotides having the (Rp) configuration at one particular phosphorothioate internucleoside linkage and the (Sp) configuration at each of the remaining phosphorothioate internucleoside linkages, or polynucleotide conjugates comprising said double-stranded oligonucleotides.

65. The chirally enriched population of claim 61, wherein the population is enriched for double- stranded oligonucleotides having at least 2 or at least 3 contiguous phosphorothioate internucleoside linkages in the Sp, Sp, and Rp configurations, in the 5’ to 3’ direction, or polynucleotide conjugates comprising said double- stranded oligonucleotides.

66. A population of double-stranded oligonucleotides comprising double-stranded oligonucleotides as defined in any one of claims 1-45, or the polynucleotide conjugates as defined in any of claims 46-60, wherein all of the phosphorothioate internucleoside linkages of the double-stranded oligonucleotides are stereorandom.

67. A pharmaceutical composition comprising a double-stranded oligonucleotide as defined in any one of claims 1-45, a polynucleotide conjugate as defined in any of claims 46-60, or a population as defined in any one of claims 61-66, and a pharmaceutically acceptable diluent or carrier.

68. The pharmaceutical composition of claim 67, wherein the pharmaceutically acceptable diluent is water or phosphate-buffered saline.

69. The pharmaceutical composition of claim 68, wherein the pharmaceutical composition consists essentially of a double-stranded oligonucleotide as defined in any one of claims 1-45, a polynucleotide conjugate as defined in any of claims 46-60, or a population as defined in any one of claims 61-66, and water or phosphate- buffered saline.

70. A method comprising administering to a subject a double-stranded oligonucleotide as defined in any one of claims 1-45, a polynucleotide conjugate as defined in any of claims 46-60, a population as defined in any one of claims 60-65, or a pharmaceutical composition as defined in any one of claims 66-68.

71. A method of treating a disease associated with PSD3 comprising administering to a subject having a disease associated with PSD3 a therapeutically effective amount of a double-stranded oligonucleotide as defined in any one of claims 1-45, a polynucleotide conjugate as defined in any of claims 46-59, a population as defined in any one of claims 61-66, or a pharmaceutical composition as defined in any one of claims 67-69; thereby treating the disease associated with PSD3.

72. The method of claim 70, wherein the disease associated with PSD3 is liver disease, fatty liver disease (FLD), nonalcoholic fatty liver disease (NAFLD), hepatic steatosis, non-alcoholic steatohepatitis (NASH), liver cirrhosis, hepatocellular carcinoma, alcoholic liver disease, alcoholic steatohepatitis (ASH), HCV hepatitis, chronic hepatitis, hereditary hemochromatosis, or primary sclerosing cholangitis.

73. The method of claim 72, wherein administering a double-stranded oligonucleotide as defined in any one of claims 1-45, a polynucleotide conjugate as defined in any of claims 46-60, a population as definedin any one of claims 61-66, or a pharmaceutical composition as defined in any one of claims 67-69 reduces liver damage, steatosis, liver fibrosis, liver inflammation, liver scarring or cirrhosis, liver failure, liver enlargement, elevated transaminases, or hepatic fat accumulation in the subject.

74. A method of reducing expression of PSD3 in a cell comprising contacting the cell with a double- stranded oligonucleotide as defined in any one of claims 1-45, a polynucleotide conjugate as defined in any of claims 46-60, a population as defined in any one of claims 61-66, or a pharmaceutical composition as defined in any one of claims 66-68.

75. The method of claim 74, wherein the cell is a liver cell.

76. Use of a double-stranded oligonucleotide as defined in any one of claims 1-45, a polynucleotide conjugate as defined in any of claims 46-60, a population as defined in any one of claims 61-66, or a pharmaceutical composition as defined in any one of claims 67-69 for treating a disease associated with PSD3.

77. Use of a double-stranded oligonucleotide as defined in any one of claims 1-45, a polynucleotide conjugate as defined in any of claims 46-60, a population as defined in any one of claims 61-66, or a pharmaceutical composition as defined in any one of claims 67-69 in the manufacture of a medicament for treating a disease associated with PSD3.

78. The use of claim 76 or 77, wherein the disease associated with PSD3 is liver disease, fatty liver disease (FLD), nonalcoholic fatty liver disease (NAFLD), hepatic steatosis, non-alcoholic steatohepatitis (NASH), liver cirrhosis, hepatocellular carcinoma, alcoholic liver disease, alcoholic steatohepatitis (ASH), HCV hepatitis, chronic hepatitis, hereditary hemochromatosis, or primary sclerosing cholangitis.

79. A double-stranded oligonucleotide as defined in any one of claims 1-45, a polynucleotide conjugate as defined in any of claims 46-60, a population as defined in any one of claims 61-66, or a pharmaceutical composition as defined in any one of claims 67-69 for use in a method of treating a disease associated with PSD3.

80. The double-stranded oligonucleotide, polynucleotide conjugate, population, or pharmaceutical composition for use of claim 79, wherein the disease associated with PSD3 is liver disease, fatty liver disease (FLD), nonalcoholic fatty liver disease (NAFLD), hepatic steatosis, non-alcoholic steatohepatitis (NASH), liver cirrhosis, hepatocellular carcinoma, alcoholic liver disease, alcoholic steatohepatitis (ASH), HCV hepatitis, chronic hepatitis, hereditary hemochromatosis, or primary sclerosing cholangitis.

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