Cosmetic composition and uses thereof

Abstract

In some aspects, the techniques described herein relate to a cosmetic composition with improved oxygen delivery properties, the composition including: an extract of spirulina; a carrier; an optional texture agent; and an antioxidant.

Description

COSMETIC COMPOSITION AND USES THEREOFCLAIM OF PRIORITY

[0001] This patent application claims the benefit of priority to FR Application Serial No. 2310605, filed October 4, 2023, which is incorporated by reference herein in its entirety.BACKGROUND

[0002] Oxygen can be delivered to skin according to various methods. Enhancing the delivery of oxygen to skin is therefore desirable.SUMMARY OF THE INVENTION

[0003] In some aspects, the techniques described herein relate to a cosmetic composition with improved oxygen delivery properties, the composition including: an extract of spirulina; a carrier; an optional texture agent; and an antioxidant.BRIEF DESCRIPTION OF THE FIGURES

[0004] Figure 1 shows the partial O2 pressure in a liposome carrier composition. The liposome carrier composition is that of Table 1. Partial O2 concentration values are shown on the Y-axis and time is on the X-axis.

[0005] Figure 2 shows the partial O2 pressure in a stearalkonium hectorite carrier composition. The stearalkonium hectorite carrier composition is that of Table 2. Partial O2 pressure values are shown on the Y-axis and time is on the X-axis.

[0006] Figure 3 shows the oxygen increase in cells treated with the compositions according to Tablel and Table 2, respectively.DETAILED DESCRIPTION OF THE INVENTION

[0007] Reference will now be made in detail to certain aspects of the disclosed subject matter. While the disclosed subject matter will be described in conjunction with the enumerated claims, it will be understood that the exemplified subject matter is not intended to limit the claims to the disclosed subject matter.

[0008] Throughout this document, values expressed in a range format should be interpreted in a flexible manner to include not only the numerical values explicitly recited as the limits of the range, but also to include all the individual numerical values or sub-ranges encompassed within that range as if each numerical value and sub-range is explicitly recited. For example, a range of “about 0.1% to about 5%” or “about 0.1% to 5%” should be interpreted to include not just about 0.1% to about 5%, but also the individual values (e.g., 1%, 2%, 3%, and 4%) and the sub-ranges (e.g., 0.1% to 0.5%, 1.1% to 2.2%, 3.3% to 4.4%) within the indicated range. The statement “about X to Y” has the same meaning as “about Xto about Y,” unless indicated otherwise. Likewise, the statement “about X, Y, or about Z” has the same meaning as “about X, about Y, or about Z,” unless indicated otherwise.

[0009] In this document, the terms “a,” “an,” or “the” are used to include one or more than one unless the context clearly dictates otherwise. The term “or” is used to refer to a nonexclusive “or” unless otherwise indicated. The statement “at least one of A and B” or “at least one of A or B” has the same meaning as “A, B, or A and B.” In addition, it is to be understood that the phraseology or terminology employed herein, and not otherwise defined, is for the purpose of description only and not of limitation. Any use of section headings is intended to aid reading of the document and is not to be interpreted as limiting; information that is relevant to a section heading may occur within or outside of that particular section. A comma can be used as a delimiter or digit group separator to the left or right of a decimal mark; for example, “0.000,1” is equivalent to “0.0001.” All publications, patents, and patent documents referred to in this document are incorporated by reference herein in their entirety, as though individually incorporated by reference. In the event of inconsistent usages between this document and those documents so incorporated by reference, the usage in the incorporated reference should be considered supplementary to that of this document; for irreconcilable inconsistencies, the usage in this document controls.

[0010] When concentrations are given as % wt it is intended relative to the total weight of the compositions also where not specifically indicated.

[0011] In the methods described herein, the acts can be carried out in any order without departing from the principles of the invention, except when a temporal or operational sequence is explicitly recited. Furthermore, specified acts can be carried out concurrently unless explicit claim language recites that they be carried out separately. For example, a claimed act of doing X and a claimed act of doing Y can be conducted simultaneously within a single operation, and the resulting process will fall within the literal scope of the claimed process.

[0012] The term “about” as used herein can allow for a degree of variability in a value or range, for example, within 10%, within 5%, or within 1% of a stated value or of a stated limit of a range, and includes the exact stated value or range. The term “substantially” as used herein refers to a majority of, or mostly, as in at least about 50%, 60%, 70%, 80%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5%, 99.9%, 99.99%, or at least about 99.999% or more, or 100%. The term “substantially free of’ as used herein can mean having none or having a trivial amount of, such that the amount of material present does not affect the material properties of the composition including the material, such that about 0 wt% to about 5 wt% ofthe composition is the material, or about 0 wt% to about 1 wt%, or about 5 wt% or less, or less than or equal to about 4.5 wt%, 4, 3.5, 3, 2.5, 2, 1.5, 1, 0.9, 0.8, 0.7, 0.6, 0.5, 0.4, 0.3, 0.2, 0.1, 0.01, or about 0.001 wt% or less, or about 0 wt%.

[0013] According to various aspects of the present disclosure a cosmetic composition is capable of delivering oxygen to a skin tissue. Delivering oxygen to skin tissue can be useful in many different applications. For example, the composition can be used as an antiaging composition, a reforming composition, an anti-wrinkle composition, an anti-dark spot composition, a skin barrier and repair treatment, a skin hydration composition, an antipollution & detoxifying composition, a skin-protecting & brightening topical preparation containing mineral and organic UV fdters, actives for pre-tanning actions or soothing agents for after sun treatments or possibly a combination thereof. The cosmetic composition is a topical-formulation: a O / W emulsion, W / O emulsion, micro- or multiple emulsions such as a cream, a lotion, a gel, a serum, a spray, a mask, a cleanser, a micellar water, a self-tan product, an oil (one or multiple phases), a sun protection product, all typical face care, body care and color treatments.

[0014] The cosmetic composition includes spirulina, which is the dried biomass of cyanobacteria of the species Arthrospira platensis, A.fusiformis and A. maxima. Specifically, spirulina platensis is the dried biomass of cyanobacteria of the species Arthrospira; more specifically it is Spirulina Platensis Powder (INCI), also known as Spirulina Platensis Extract (INCI), both CAS Nr 223751-80-2, the powder obtained from the dried ground of the algae Arthrospira platensis, Cyanophyceae. In addition to the spirulina, the extract can include glycerin. Spirulina platensis includes an active ingredient that ultimately delivers the oxygen. That active ingredient is thought to be phycocyanin, which is a protein belonging to the family of phycobiliproteins found in particular in seaweed. Phycocyanin can be isolated and purified from species such as Aphanizomenon flos-quae, Arthrospira platentis, Spirulina fusiformis, Phormidium Sp, Lyngbya Sp., Synechosystis Sp. nd Synechococcus Sp. It is a protein complex from the light-harvesting family, along phycoerythrin. It is an accessory pigment to chlorophyll. Each subunit is typically composed of eight a-helices. Monomers spontaneously aggregate to form ring-shaped trimers (aP)s, which have rotational symmetry and a central channel. Trimers aggregate in pairs to form hexamers (aP)6, sometimes assisted with additional linker proteins. Each phycobilisome rod generally has two or more phycocyanin hexamers. Despite the overall similarity in structure and assembly of phycobiliproteins, there is a large diversity in hexamer and rod conformations, even when only considering phycocyanins.

[0015] Relative to the total weight of the cosmetic composition, spirulina, in particular Spirulina Platensis Powder, can be in a range of from about 0.00001 wt% to about 10 wt%, about 0.00005 wt% to about 8 wt%, about 0.00008 wt% to about 0.012 wt%, less than, equal to, or greater than about 0.00001 wt%, 0.00005, 0.00010, 0.000050, 0.001, 0.005, 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.1, 0.11, 0.12, 0.13, 0.14, 0.15, 0.16, 0.17, 0.18, 0.19, 0.2, 0.3, 0.4, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5, or about 10 wt%.

[0016] The carrier of the cosmetic composition can be a clay or a liposome. Examples of suitable clays can include bentonite, hectorite, stearalkonium hectorite & propylene carbonate, rhassoul clay, French green clay, fuller’s earth clay, yellow clay, or a mixture thereof. Stearalkonium Hectorite in combination with propylene carbonate is preferred.

[0017] Liposomes are considered the most commonly used nanocarriers for various potentially active hydrophobic and hydrophilic molecules due to their high biocompatibility, biodegradability, and low immunogenicity. Liposomes have also been proven to enhance drug solubility and controlled distribution, as well as their capacity for surface modifications for targeted delivery into skin, prolonged, and sustained release. Based on the composition, liposomes can be considered to have evolved from conventional, long-circulating, targeted, and immune-liposomes to stimuli-responsive and actively targeted liposomes. Many liposomal-based drug delivery systems are currently clinically approved to treat several diseases, such as cancer, fungal and viral infections; more liposomes have reached advanced phases in clinical trials. According to the liposomes structures, they are classified into four categories based on size and number of bilayers: small unilamellar vesicles (SUV), large unilamellar vesicles (LUV), multilamellar vesicle (MLV), and multivesicular vesicles (MW). Liposomes have mono phospholipid bilayer in a unilamellar structure, while they have an onion-like structure in a multilamellar structure. MW form a multilamellar arrangement with concentric phospholipid spheres as many unilamellar vesicles are produced within larger liposomes. The size of the vesicles is an important factor that controls the circulation half-life of liposomes. Both the size and number of bilayers influence the amount of the encapsulated active ingredient(s). Liposomes interaction with the cell membrane is represented by various theories: specific (modified with receptor-mediated) or nonspecific endocytosis, local fusion (adhesion), phagocytosis, and absorption into the cell membrane. Liposome-cell interactions are influenced by a variety of factors, including composition, the diameters of liposomes, surface charge, targeting ligand on the liposome surface, and biological environment.

[0018] Relative to the total weight of the cosmetic composition, the carrier is in a range of from about 0.01 wt% to about 70 wt%, about 20 wt% to about 50 wt%, less than, equal to, or greater than about 0.01 wt%, 0.5, 1, 1.5, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, or about 70 wt%.

[0019] The texture agent emollient can include a mixture of dicaprylyl carbonate & tocopherol, a mixture of caprylic / capric triglyceride, a mixture of caprylic / capric triglyceride & castor oil / ipdi copolymer, or a combination thereof. Additional examples of emollients include mono-, di-, and tri-glycerides and butters and hydrogenated versions of seed and nut oils including but not limited to; palm oil, coconut oil, vegetable oil, avocado oil, canola oil, com oil, soy bean oil, sunflower oil, safflower oil, meadowfoam seed oil, bilberry sead oil, watermelon seed oil, olive oil, cranberry, macadamia nut oil, argan oil, pomegranate oil, argan Moroccan oil, blue berry oil, raspberry oil, walnut oil, pecan oil, peanut oil, bayberry oil, mango seed oil, Manila oil, castor oil, Shea butter, jojoba oil, hydrolyzed jojoba oil, Carnauba butter, Carnauba wax, castor isostearate succinate, stearyl heptanoate, cetyl ricinoleate, oleyl frucate, sucrose monostearate, sucrose distearate, sucrose tristearate, sucrose tetrastearate, candelilla wax, soybean wax, Rapeseed wax, palm wax, bees wax, petrolatum, myristyl myristate, Oleyl Erucate, squalane, stearyl alcohol, Cetearyl isononanoate, polyisobutene, glyceryl stearate, glyceryl distearate, cetyl alcohol, lanolin, lanolin ethoxylate, low molecular weight polyethylene waxes, lower molecular weight polypropylene waxes, PEG-30 glyceryl cocoate, PEG-80 Glyceryl cocoate, Glyceryl stearate, PEG-8 Ricinoleate, PEG-8 Raspberriate, Linear (otherwise known as bis) and pendent versions of including hydroxyl terminated and methyl ether terminated; PEG- 3 to PEG-32 Dimethicone (including but not limited to: PEG-3 Dimethicone, Dimethicone, PEG-9 Dimethicone, PEG- 10 Dimethicone, PEG- 11 Methyl ether dimethicone, PEG- 12 Dimethicone, PEG- 14 Dimethicone, PEG- 17 Dimethicone, PEG-Dimethicone), bis- PEG / PPG-20 / 20 Dimethicone, PEG / PPG 20 / 23 Dimethicone, PEG / PPG 20 / 22 Butyl Ether Dimethicone, PEG / PPG 23 / 6 Dimethicone, PEG / PPG 20 / 15 Dimethicone. Alkyl modified dimethicone (stearoxy dimethicone, behenoxy dimethicone, cetyl dimethicone, cetearyl methicone; C30-45 Alkyl cetearyl dimethicone copolymer, Alkyl dimethicone, caprylyl methicone, PEG-8 dimethicone / dimer dilinoleic acid copolymer, Bis-PEG-10 Dimethicone / Dimer Dilinoleate Copolymer, Stearoxymethicone / Dimethicone Copolymer, Diphenyl dimethicone, Lauryl polyglycerol-3 polydimethylsiloxyethyl dimethicone, LaurylPEG-9 polydimethylsiloxyethyl dimethicone, Dimethicone fluids(>20cst), quatemized ammonia silicone polymers, Amino silicones, silicone quatemium-18, Amodimethicone, phenyltrimethicone, amino silicone polyethers, Polyglycerol-3 Disiloxane dimethicone, Polyglycerol-3 polydimethylsiloxyethyl dimethicone, silica dimethyl silylate, bambusa arundinacea, and PEG-9 polydimethylsiloxyethyl dimethicone.

[0020] Relative to the total weight of the cosmetic composition, the texture agent is in a range of from about 10 wt% to about 60 wt%, about 20 wt% to about 40 wt%, less than, equal to, or greater than about 10 wt%, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, or about 60 wt%.

[0021] Antioxidants slow, protect against, and help repair the adverse effects of oxidative degradation. The antioxidant can include a mixture of diethylhexyl syringylidenemalonate & caprylic / capric triglyceride, or a combination thereof. Other antioxidants include vitamin C and its derivates, niacinamide, resveratrol, vitamin E and its derivates, retinol and its derivates, coenzyme Q10, and polyphenols and diethylhexyl syringylidenemalonate. Relative to the total concentration of the cosmetic composition, the antioxidant is in a range of from about 0.05 wt% to about 20 wt%, about 5 wt% to about 15 wt%, less than, equal to, or greater than about 2 wt%, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or about 20 wt%

[0022] A specific example of a cosmetic composition in which the spirulina platensis is present in a liposome carrier includes the composition shown in Tables 1 and 2.Table 1Table 2A specific example of a cosmetic composition in which the spirulina platensis is present in a clay carrier includes the composition shown in Table 3.Table 3:

[0023] In addition to the aforementioned components, the cosmetic composition can include any compound generally accepted in the cosmetic and dermatological field. The invention makes it possible to achieve a multitude of compositions.

[0024] The cosmetic composition can include anti-aging and / or anti-wrinkle compounds, alone or as a mixture, chosen from the group comprising adenosine, hyaluronic acid, cocoa leaf extract and tocopheryl acetate. It is particularly advantageous to combine spirulina, in particular spirulina platensis, and a compound exhibiting anti-wrinkle, anti-aging or antioxidant activity so as to result in compositions exhibiting increased anti-aging activity.

[0025] The cosmetic composition can include a moisturizing and soothing compound such as mineral water and glycerin. The cosmetic composition can include gelling and texturizing compounds, alone or as a mixture, chosen from the group consisting of polyacrylate crosspolymer; polymethylcrosspolymer; polymethyl methacrylate; talc; boron nitride; isocetyl stearate; xanthan gum; Hydroxypropyl Methylcellulose; Hydroxyethyl Cellulose; hydroxyethyl Acrylate / Sodium Acryloyldimethyl Taurate Copolymer & Water &Squalane & Polysorbate 60 & Sorbitan Isostearate; Acrylates / C 10-30 Alkyl Acrylate Crosspolymer; Water & Acrylates / Vinyl Neodecanoate Crosspolymer; Hydroxyethyl Aery late / S odium Acryloyldimethyl Taurate Copolymer & Polysorbate 60 & Sorbitan Isosteararate & Water; Magnesium Aluminium Silicate; Carrageenan; Alginate; Calcium Alginate; Sodium Polyacrylate Starch; Hydroxypropyl Starch; Starch Powders (Rice, Com, Cassava or Tapioca); Hydroxypropyl Starch Phosphate & Water; Pectin; Gelatin; Agar Agar; Gellan Gum; Sclerotium Gum; Tragacanth; Tapioca Starch; Guar Gum; Carob Gum; Acacia Gum; Arabic Gum.

[0026] The cosmetic composition can include preservatives, alone or as a mixture, chosen from the group consisting of chlorphenesin, o-cymen-5-ol and 1 ,2-Hexanediol; Benzyl Alcohol; Benzoic Acid; Dehydroacetic Acid; Musa Sapientum (Banana) Extract; Sodium Benzoate & Potassium Sorbate, Ethylhexylglycerin; or a mixture thereof.

[0027] The cosmetic composition can include emulsifying agents, alone or as a mixture, chosen from the group consisting of potassium cetyl phosphate, C20-22 alkyl phosphate & C20-22 alcohols, glyceryl stearate, PEG- 100 stearate, polysorbate 60, Cetyl Alcohol, Stearyl Alcohol, Stearic Acid & Palmitic Acid, Polyglyceryl-6-Stearate & Polyglyceryl-6 Behenate, Tribehin PEG-20 Esters, Cetearyl Alcohol & Cetearyl Glucoside, Hydrogenated Coco Glycerides, PEG-40 Hydrogenated Castor Oil, Glyceryl Stearate (SE), PEG- 100 Stearate & Glyceryl Stearate, or a mixture thereof

[0028] The cosmetic composition can include thickening agents, alone or as a mixture, chosen from the group consisting of cetyl alcohol, vegetable waxes such as jojoba ester & acacia decurrensflower wax, acacia decurrens flower wax & heliantuus annuus seed wax, bees wax (cera alba), carnauba wax, and mixtures thereof.

[0029] The cosmetic composition can include fdm-forming agents, alone or as a mixture, chosen from the group consisting of isononyl isononanoate, dimethicone and plant gels such as tara fruit extract, Kappaphycus Alvarrezii extract, Konjac mannan, chitosan, and add Biosaccharide-Gum, Capryloyl Glycerin / Sebacic acid Copolymer, other biobased polymers made from tung or rapeseed or other vegetal oils, Ethylcellulose & Diisopropyl Adipate, or a mixture thereof.

[0030] The cosmetic composition can include solvents, alone or as a mixture, chosen from the group consisting of water, dicaprylyl carbonate, propylene glycol, dipropylene glycol, ethanol, butylene glycol, or a mixture thereof.

[0031] The cosmetic composition can include pH adjusters, alone or as a mixture, chosen from the group consisting of citric acid, sodium hydroxide, Triethanolamine and Tromethamine.

[0032] The cosmetic composition can include lipid-replenishing agents, alone or as a mixture, chosen from the group consisting of squalane and shea butter, as well as butters from mango seed, olive, almond, cocoa, coconut, macadamia, or babassu.

[0033] The cosmetic composition can include stabilizing agents, alone or as a mixture, as well as emulsifiers chosen from the previously mentioned functional ingredients.

[0034] The cosmetic composition can include hydrogenated vegetable oil, Cocamidopropyl Betaine & Glyceryl Oleate, mica, tin oxide and titanium dioxide or other pigments and pearl powders.

[0035] The cosmetic composition can include UV Light Absorbers or Reflectors as well as SPF booster agents, alone or as a mixture, chosen from the group consisting of for example butylmethoxydibenzoylmethane, octocrylene, ethylhexyl methoxycinnamate, octyl salicylate, ethylhexyltriazone, bis ethylhexyloxyphenol methoxyphenyl triazine, Ethylhexyl Triazone, Phenylbenzimidazole Sulfonic Acid, Methylene Bis-Benzotriazolyl Tetramethylbutylphenol, Diethylamino Hydroxybenzoyl Hexyl Benzoate and others.

[0036] The cosmetic composition can also include Caffeine, Niacinamide, Vitamins from E, A, C and F Group and its derivates, Creatin Palmitoyl Tripeptide-5, Panthenol, or mixtures thereof.EXAMPLES

[0037] Compositions of those listed in Table 1 and Table 2 were studied for the oxygen loading capabilities. To do the oxygen loading, a CAIRE inc, Us, VisionAire 5 oxygen concentrator device is used. With the oxygen concentrator, air is drawn into the device through its air intakes, where the air passes through a molecular sieve. Oxygen is separated from nitrogen and allows only the pure oxygen to pass out of the device. This produces a flow of high concentration of pure (medical) quality. A specific connected tubing transports the pure oxygen to its destination into the carriers which are prepared as following described.

[0038] The flow rate of the air was 1 - 5L / min. A chosen volume of one of the spirulina platensis Carrier Systems (the composition of Table 1, Table 2 or Table 3) is filled into a beaker (covered by a plastic film) under slow to middle speed stirring with a typicaladapted device mixer from the type Raynerie Turbotest (VMI, France) or IKA RW 20 Digital Mixer (IKA Werke Germany). The freshly produced O2 flows from the O2 concentrator passing a specific silicon tubing (Westmed Inc. US) into the carrier. Loading time and flow rate depends on the volumes to be loaded from 100 ml to 5L. The protocol is optimized by choosing from 1 to 30 minutes loading time by a flow rate from 1 to 5 L / min.

[0039] Results are shown below in Figures 1, 2 and 3.

[0040] To generate the data, hypoxia conditions were induced on normal human fibroblasts by using dimethyloxalylglycine treatment. Once hypoxia was generated, cells were then incubated with the respective compositions. Intracellular oxygen content was quantified by using the Winkler method. The Winkler method generally involves filling a sample bottle completely with water (no air is left to bias the test). The dissolved oxygen is then "fixed" using a series of reagents that form an acid compound that is titrated. Titration involves the drop-by-drop addition of a reagent that neutralizes the acid compound and causes a change in the color of the solution. The point at which the color changes is the "endpoint" and is equivalent to the amount of oxygen dissolved in the sample. The sample is usually fixed and titrated in the field at the sample site. It is possible, however, to prepare the sample in the field and deliver it to a lab for titration. Oxygen content was compared to the non- treated cells.Exemplary Aspects.

[0041] The following exemplary aspects are provided, the numbering of which is not to be construed as designating levels of importance:Aspect 1 provides a cosmetic composition with improved oxygen delivery properties, the composition comprising: spirulina; a carrier; an texture agent; and an antioxidant.

[0042] Aspect 2 provides the cosmetic composition of Aspect 1, wherein spirulina is spirulina platensis.

[0043] Aspect 3 provides the cosmetic composition of Aspect 2, wherein spirulina platensis is an aqueous extract and preferably further comprises glycerin.

[0044] Aspect 4 provides the cosmetic composition of any of Aspects 1-3, wherein the extract of spirulina platensis is in a range of from about 1 wt% to about 10 wt%.

[0045] Aspect 5 provides the cosmetic composition of any of Aspects 1-4, wherein the extract of spirulina platensis is in a range of from about 3 wt% to about 8 wt%.

[0046] Aspect 6 provides the cosmetic composition of any of Aspects 1-5, wherein the extract of spirulina platensis comprises an active ingredient.

[0047] Aspect 7 provides the cosmetic composition of Aspect 6, wherein the active ingredient comprises phycocyanin.

[0048] Aspect 8 provides the cosmetic composition of any of Aspects 1-7, wherein the carrier comprises a clay or a liposome and the liposome optionally comprises a cationic charge, and an EGF ligand.

[0049] Aspect 9 provides the cosmetic composition of Aspect 8, wherein the clay comprises bentonite hectorite.

[0050] Aspect 10 provides the cosmetic composition of any of Aspects 1-9, wherein the carrier is in a range of from about 1 wt% to about 60 wt%.

[0051] Aspect 11 provides the cosmetic composition of any of Aspects 1-10, wherein the carrier is in a range of from about 20 wt% to about 50 wt%.

[0052] Aspect 12 provides the cosmetic composition of any of Aspects 1-11, wherein the texture agent comprises a mixture of, or a combination thereof.

[0053] Aspect 13 provides the cosmetic composition of any of Aspects 1-12, wherein the texture agent is in a range of from about 10 wt% to about 60 wt%.

[0054] Aspect 14 provides the cosmetic composition of any of Aspects 1-13, wherein the texture agent is in a range of from about 20 wt% to about 40 wt%.

[0055] Aspect 15 provides the cosmetic composition of any of Aspects 1-14, wherein the antioxidant comprises a mixture of diethylhexyl syringylidenemalonate & caprylic / capric triglyceride, or a combination thereof.

[0056] Aspect 16 provides the cosmetic composition of any of Aspects 1-15, wherein the antioxidant is in a range of from about 2 wt% to about 20 wt% of the composition.

[0057] Aspect 17 provides the cosmetic composition of any of Aspects 1-16, wherein the antioxidant is in a range of from about 5 wt% to about 15 wt% of the composition.

[0058] Aspect 18 provides a cosmetic composition comprising:

[0059] Aspect 19 provides a cosmetic composition comprising:

[0060] Aspect 20 provides the cosmetic composition of any of Aspects 1-19, wherein the composition as an anti-aging composition, a reforming composition, an anti-wrinkle composition, an anti-dark spot composition, a skin barrier and repair treatment, a skinhydration composition, an anti-pollution & detoxifying composition, a skin-protecting & brightening topical preparation containing mineral and organic UV fdters, actives for pretanning actions or soothing agents for After Sun treatments or possibly a combination thereof. The cosmetic composition is a topical-formulation: a O / W emulsion, W / O emulsion, micro- or multiple emulsions such as a cream, a lotion, a gel, a serum, a spray, a mask, a cleanser, a micellar water, a self-tan product, an Oil (One or multiple phases), a Sun Protection product, all typical Face, Body Care and Color treatments.

[0061] Aspect 21 provides a method of making the cosmetic composition of any ofAspects 1-20, the method comprising mixing the extract of spirulina; the carrier; the optional texture agent; and the antioxidant.

[0062] Aspect 22 provides a cosmetic carrier comprising: a carrier comprising a clay or a liposome; and optionally a supply of oxygen bubbled into the carrier.

[0063] Aspect 23 provides a method of using the composition of any of Aspects 1-22, the method comprising applying the composition to a skin tissue.

Claims

CLAIMSWhat is claimed is:

1. A cosmetic composition for oxygen delivery to dermal cells, the composition comprising: spirulina; a carrier, the carrier being a clay or a liposome; an optional texture agent; an antioxidant; and a supply of oxygen bubbled into the carrier.

2. The cosmetic composition of claim 1, wherein spirulina is spirulina platensis extract (INCI, CAS 223751-80-2), preferably further comprising glycerin.

3. The cosmetic composition of any of claims 1 or 2, wherein the spirulina platensis extract is in a range of from 1 wt% to 10 wt%, preferably in a range of from 3 wt% to 8 wt% relative to the weight of the composition.

4. Cosmetic composition according to any of claims 1-3, wherein the liposome comprises a optional cationic charge and an EGF ligand.

5. The cosmetic composition of any of claims 1-4, wherein the clay comprises stearalkonium hectorite.

6. The cosmetic composition of any of claims 1-5, wherein the carrier is in a range of from 1 wt% to 70 wt%, preferably in a range of from 20 wt% to 50 wt%.

7. The cosmetic composition of any of claims 1-6, wherein the texture agent comprises a mixture of dicaprylyl carbonate & tocopherol, a mixture of caprylic / capric triglyceride, a mixture of caprylic / capric triglyceride & castor oil / ipdi copolymer, or a combination thereof.

8. The cosmetic composition of any of claims 1-7, wherein the texture agent is in a range of from 10 wt% to 60 wt%, preferably in a range of from 20 wt% to 40 wt%.

9. The cosmetic composition of any of claims 1-8, wherein the antioxidant comprises a mixture of diethylhexyl syringylidenemalonate & caprylic / capric triglyceride, tocopheryl acetate, or a combination thereof.

10. The use of any of claims 1-9, wherein the antioxidant is in a range of from 2 wt% to 20 wt% of the composition, preferably in a range of from 5 wt% to 15 wt% of the composition.

11. A cosmetic composition according to claim 1 comprising:

12. A cosmetic composition according to claim 1 comprising:WATER & GLYCERIN & SPIRULINA PLATENSIS POWDER13. The cosmetic composition of any of claims 1-12, wherein the composition is used as an anti -aging composition, a reforming composition, an anti-wrinkle composition, an antidark spot composition, a skin barrier and repair treatment, a skin hydration composition, an anti-pollution & detoxifying composition, a skin-protecting & brightening topical preparation containing mineral and organic UV filters, actives for pre-tanning actions or soothing agents for After Sun treatments or possibly a combination thereof. The cosmetic composition is a topical-formulation: a O / W emulsion, W / O emulsion, micro- or multiple emulsions such as a cream, a lotion, a gel, a serum, a spray, a mask, a cleanser, a micellar water, a self-tan product, an Oil (One or multiple phases), a Sun Protection product, all typical Face, Body Care and Color treatments.

14. Use of a cosmetic composition comprising: spirulina; a carrier, the carrier being a clay or a liposome; an optional texture agent; an antioxidant to improve oxygen delivery to dermal cells, preferably wherein spirulina is spirulina platensis extract (INCI, CAS 223751-80-2).

15. A method for improved oxygen delivery to dermal cells, the method comprising the steps of a) providing a cosmetic composition comprising: spirulina; a carrier, the carrier being a clay or a liposome; an optional texture agent; and an antioxidantb) bubbling a supply of oxygen into the carrier, preferably wherein spirulina is spirulina platensis extract (INCI, CAS 223751-80-2).

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