Method and device for phototherapy using a hybrid light source

Abstract

The present invention relates to a phototherapy device comprising a white light LED configured to emit homogenized light intensity at all wavelengths within the visible range, or a hybrid light source, and method of treatment of a disease, disorder or condition using the same.

Description

Method and Device for Phototherapy Using a Hybrid Light SourceCROSS REFERENCE TO RELATED APPLICATIONS

[0001] This application claims the benefit of U.S. Provisional Pat. App. Nos. 63 / 616,632, filed December 31, 2023, all of which are incorporated by reference in their entirety.TECHNICAL FIELD

[0002] The present invention relates to phototherapy using a white light LED or a hybrid light source, and in particular, to white light LED or a hybrid light source which is optimized in intensity and wavelength to promote wound healing and overall tissue health.BACKGROUND OF THE INVENTION

[0003] Extensive work by many investigators has demonstrated that light therapy (LT) using broadband visible and near infrared (NIR) light irradiation play two essential therapeutic roles: first, the killing of harmful bacteria through the formation of high amounts of reactive oxygen species (ROS) and second, the stimulation of wound healing following low amounts of ROS, by enhancing the production of fibroblasts which bind to the collagen matrix needed for the regeneration of connective tissue, especially skin. The light intensities and wavelengths that are most efficient in providing these therapies extend over the entire visible and near IR broadband spectrum, and vary according to the specific type of treatment required.

[0004] For example, US Patent no. 6,379,376 to R. Lubart, dated April 30, 2002, and entitled "Device for light irradiation onto tissue", discloses a method and device for inducing or promoting growth and proliferation of skin cells or tissue or for controlling bacterial skin infection. Skin cells are irradiated with a low- intensity broad spectrum light at a wavelength of between 340 and 3000 nm. The increase in rate of cultivated cells is useful for example to obtain skin-like tissue needed for skin grafts or for promoting healing of skin wounds or lesions. Light at a higher intensity induced skin bacterial control that is useful for example in the treatment of bacterial and fungal infections of the skin.

[0005] Low level light therapy (LLLT) has also been studied extensively for the treatment of diabetic or venous foot ulcers and other types of wounds. For example, a paper by Z. Landau et al., entitled "Visible Light-Induced Healing of Diabetic or Venous Foot Ulcers: A Placebo-Controlled DoubleBlind Study", published in Photomedicine and Laser Surgery, 29 (6): 2011.399-404, reports on astudy to evaluate the efficacy of a broadband (400-800 nm) visible light device in the treatment of leg or foot ulcers. In the study, a significant improvement in wound closure rates was obtained with broadband irradiation of 180 milliwatts per square centimeter (mW / crn2) applied for 4 minutes at a time, twice daily.

[0006] Two other examples indicate the need for significant light wavelengths at both ends of the broadband visible spectrum. First, at the high-wavelength end of the spectrum, the US Food and Drug Administration (FDA) has approved the use of NIR, typically at 823 nm. wavelength, for the treatment of cutaneous T-cell lymphoma and certain kinds of skin, lung, and esophageal cancer. Second, at the low-wavelength end of the spectrum, laboratory experiments reported in a paper by Beckmann, entitled “Low Level Laser Therapy for the Treatment of Diabetic Foot Ulcers: A Critical Survey”, appearing in Evidence-Based Complementary and Alternative Medicine, vol. 2014, have shown that irradiation with blue light, typically at 470 nm. wavelength, increases keratin expression and improves wound healing via a nitric oxide (NO)-mitochondrial pathway.

[0007] The above examples indicate that the ideal LT device must be able to provide irradiation over a broad range of wavelengths for biostimulation, in addition to specific wavelengths, such as blue light, for bacterial killing in wounded tissue. Several such devices have been proposed in the literature. For example, US patent number 11,471,696 to A. Godavarty et al., dated October 18, 2022, and entitled "Handheld devices for wound assessment using multi-modal imaging", provides devices and methods for tissue assessment. The devices can be used for virtual medicine (VM)-based wound management, such as VM-based diabetic foot triage (DFT) and management. The device can be used to take physiological measurements of temperature and / or tissue oxygenation of a wound to assess the wound, for example in a remote setting environment The device can also be used to provide therapy for tissue repair and / or wound healing, apart from the multi-modal imaging of the tissue surface of the patient. For example, light therapy, can be provided via one or more light emitting diodes (LEDs) and / or laser diodes.

[0008] Methods have also been developed for tuning mixtures of LED's to produce a desired spectral output. For example, US patent number 11,490,479 to W. R. McGrath et al., dated November 1, 2022, and entitled "Systems and Methods for Tunable LED Lighting", teaches a tunable lighting system which includes a first LED having a first spectral output, a second LED having a second spectral output, and a correction circuit including a correction LED. The correction circuit in thetunable lighting system controls the correction LED to emit light that, when combined with light output from the first and second LEDs, produces a selected spectral characteristic.SUMMARY OF THE INVENTION

[0009] According to one aspect of the invention there is disclosed a device comprising an at least one white light-emitting diode (LED), wherein the white LED emits homogenized light intensity at all wavelengths within the visible range, 400 to 800 nm.

[0010] In some embodiments, the at least one white LED characterized by an intensity from 10 mW / cm2, to 500 mW / cm2.[Oi l] In some embodiments, a plurality of the at least one white LED form an array emitter.

[0012] In some embodiments, the device further comprising an at least one narrow band emitter, configured to emit light in an overlapping wavelength range of 380 to 830 nm.

[0013] In some embodiments, the device further comprising a current regulator configured to adjust the emitters, intensity or both.

[0014] In some embodiments, the device further comprising a field-of-view (FOV) adaptor configured to distribute emitted light uniformly across a treatment area

[0015] In some embodiments the FOV adaptor comprises a light pipe for application in specialized treatment areas.

[0016] In some embodiments, the device further comprising a timer configured to control light exposure duration.

[0017] In some embodiments, the device further comprising a temperature sensor configured to adjust current inputs to maintain consistent intensity from the white LED.

[0018] In some embodiments, the device is for use in phototherapy of a disease, a disorder or condition in a subject in need thereof.

[0019] In some embodiments, the disease, the disorder or the condition is selected from the group consisting of skin condition, bilirubin reduction, seasonal affective disorder, circadian rhythm disorder, wound healing, muscle recovery, oral mucositis, chronic pain management, hair loss, anti-aging, allergies, including any combination thereof.

[0020] According to another aspect of the invention there is disclosed a method for photo-treating a disease, a disorder or condition in a subject in need thereof, the method comprising: (a) exposing subj ect tissue to the a phototherapy device; (b) selecting treatment parameters comprising duration, wavelength bands and intensity; and (c) irradiating the tissue with an at least one emitter at suitable condition; wherein the at least one emitter comprising a white light-emitting diode (LED) characterized by emitting homogenized light intensity at all wavelength within the visible range, range of 400 to 800 nm.

[0021] In some embodiments, the at least one white LED is characterized by an intensity from 10 mW / cm2to 500 mW / cm2.

[0022] In some embodiments, a plurality of the at least one emitter form an array emitter.

[0023] In some embodiments, the method further comprising an at least one narrow band emitter, configured to emit light in an overlapping wavelength range of 380 to 830 nm.

[0024] In some embodiments, the initiation is controlled manually, automatically, or both.

[0025] In some embodiments, the automatically controlled is by sensor feedback.

[0026] In some embodiments, the phototherapy device further comprises a correction circuit configured to refine spectral outputs.

[0027] In some embodiments, the phototherapy device further comprises and imaging sensor configured to assess tissue conditions in real time during irradiation.

[0028] According to another aspect there is disclosed a device comprising a hybrid light source (HLS) wherein HLS comprises an at least one white LED and an at least one narrow band emitter at an array of emitters.

[0029] In some embodiments, the at least one white LED is configured to emit light at a wavelength range of 400 to 800 nm.

[0030] In some embodiments, the at least one white LED characterized by an intensity from 10 mW / cm2to 500 mW / cm2.

[0031] In some embodiments, a plurality of the at least one white LED form an array emitter.

[0032] In some embodiments, the at least one narrow band emitter is configured to emit light in an overlapping wavelength range of 380 to 830 nm.

[0033] In some embodiments, the device further comprising a current regulator configured to adjust the emitters, intensity or both.

[0034] In some embodiments, the device further comprising a field-of-view (FOV) adaptor configured to distribute emitted light uniformly across a treatment area.

[0035] In some embodiments, the FOV adaptor comprises a light pipe for application in specialized treatment areas.

[0036] In some embodiments, the device further comprising a timer configured to control light exposure duration.

[0037] In some embodiments, the device further comprising a temperature sensor configured to adjust current inputs to maintain consistent intensity from the HLS.

[0038] In some embodiments, the device is for use in phototherapy of a disease, a disorder or condition in a subject in need thereof.

[0039] In some embodiments, the disease, the disorder or the condition is selected from the group consisting of skin condition, bilirubin reduction, seasonal affective disorder, circadian rhythm disorder, wound healing, muscle recovery, oral mucositis, chronic pain management, hair loss, anti-aging, allergies, including any combination thereof.

[0040] According to another aspect of the inventio there is provided a method for photo-treating a disease, a disorder or a condition in a subject in need thereof; comprising: (i) exposing subject tissue to the a phototherapy device; (ii) selecting treatment parameters comprising duration and wavelength bands; and irradiating the tissue with HLS at suitable condition; wherein, HLS comprises an at least one white LED and an at least one narrow band emitter.

[0041] In some embodiments, the white LED is configured to emit homogenized light intensity at all wavelengths within the visible range, 400 to 800 nm.

[0042] In some embodiments, the at least one white LED is characterized by an intensity from 10 mW / cm2to 500 mW / cm2.

[0043] In some embodiments, the at least one narrow band emitter is narrow band configured to emit light in an overlapping wavelength range of 380 to 830 nm.

[0044] In some embodiments, HLS is in a form of an array.

[0045] In some embodiments, the initiation is controlled manually, automatically, or both.

[0046] In some embodiments, the automatically controlled is by sensor feedback.

[0047] In some embodiments, the phototherapy device further comprises a correction circuit configured to refine spectral outputs.

[0048] In some embodiments, the phototherapy device further comprises and imaging sensor configured to assess tissue conditions in real time during irradiation.BRIEF DESCRIPTION OF THE DRAWINGS

[0049] Some embodiments of the present invention are herein described, by way of example only, with reference to the accompanying drawings. With regard to the drawings in detail, it is stressed that the particulars shown are by way of example and for purposes of illustrative discussion of embodiments of the invention. In this regard, the description taken with the drawings makes apparent to those skilled in the art how embodiments of the invention may be practiced.

[0050] Dimensions of components and features shown in the figures are chosen for convenience or clarity of presentation and are not necessarily shown to scale. Wherever possible, the same reference numbers will be used throughout the drawings and the following description to refer to the same and like parts.

[0051] FIG. 1 : A graph of the wavelength bands of an exemplary HLS, according to the invention;

[0052] FIG. 2: An exemplary block diagram of an HLS device;

[0053] FIG. 3: An exemplary FOV adaptor which includes a light pipe;

[0054] FIG. 4: A block diagram of a method for using the HLS device in phototherapy;

[0055] FIGs. 5A-5B: images comparing a wound in a subject having diabetic (5A) before and after (5B) treatment with the phototherapy device according to some embodiments of the present invention;

[0056] FIGs. 6A-6B: images comparing a wrinkle fine line around the mouth and a chin fine line (6A) before and after (6B) treatment with the phototherapy device according to some embodiments of the present invention;

[0057] FIGs. 5A-5B: images comparing scaring of a face (7A) before and after (7B) treatment with the phototherapy device according to some embodiments of the present invention;.DETAILED DESCRIPTION OF THE INVENTION

[0058] As used herein, the term "white LED" refers to a white LED that emits light that appear homogenous due to the blending of wavelengths or the diffusion of light across a phosphor layer.

[0059] As used herein, the term "hybrid light source" (HLS) denotes an electro- optical device consisting of an at least one emitter selected from a group consisting of LEDs, laser diodes, multi -LED arrays, white LED with homogenized intensity in the visible range, fluorescent arrays, incandescent arrays, or halogen lamps, including any combination thereof, and a narrow band emitter. HLS source further comprises a current regulator for adjusting the brightness of the emitters, and a field- of-view (FOV) adaptor consisting of optical elements (e g., lenses, mirrors, and lightguides) to control the focusing and / or defocusing of the emitted light in order to provide approximately uniform irradiation over one or more desired FOVs. Non-limiting examples of light array emitters include but are not limited to linear LED, planer LED high-power LED, or halogen, including any combination thereof. In some embodiments, the at least one emitter comprises an array of emitters.

[0060] As used herein the terms "emitters" and "light array emitters" are used interchangeably.

[0061] As used herein, the term "light-induced cell growth acceleration" (LCGA) is used in this specification to denote the use of light irradiation to increase the rate of growth and proliferation of cells.

[0062] As used herein the term "light-induced bacterial control" (LBC) denotes the use of light irradiation to control bacterial and fungal infections.

[0063] As used herein, the term "light therapy" denotes the use of light irradiation to accelerate healing and anti-aging processes.

[0064] As used herein, the term "phototherapy" is used to include all of the above therapeutic applications, and also, the use of photosensitizer and / or photothermal materials applied to the skin in order to enhance the therapeutic benefits of the light irradiation.

[0065] As used herein, the term "narrow band" refers to a light source that emits energy within a very specific and narrow range of wavelengths or frequencies. These emitters are characterized by aprecise spectral output and minimized interference from other wavelengths or frequencies. Non limiting example of narrow band light source include but are not limited to lasers, monochromatic LEDS with filters, fluorescent lamps with narrowband phosphors, or gas discharge lamps with filters, including any combination thereof.

[0066] In some embodiments, the narrow band light source is characterized by a waveband of up to 50 nm, up to 40 nm, up to 30 nm, or up to 20 nm, including any combination thereof.

[0067] In some embodiments, the narrow band light source is characterized by a waveband of between 2 nm and 50 nm, between 2 nm and 40 nm, between 2 nm and 30 nm, between 2 nm and 20 nm, or between 2 nm and 10 nm, including any combination thereof.

[0068] According to one aspect of the present invention, there is provided a device comprising an at least one white light-emitting diode (LED). In some embodiments, the white LED emits homogenized light intensity at all wavelengths within the visible range, 400 to 800 nm. As used herein, the term "homogenized light intensity" refers to a device that the light emitted appears homogenous due to blending of wavelengths or the diffusion of light across a phosphor layer.

[0069] In some embodiments, the at least one white LED characterized by an intensity from 10 mW / cm2, to 500 mW / cm2. In some embodiments, the at least one white LED is in a form of an array. A person skilled in the art would appreciate that Exposure of tissue or skin to light intensities exceeding 500 mW / cm2can cause thermal damage, including burns, redness, blistering, and potential scarring due to rapid heating. Photochemical effects, especially at UV or blue light wavelengths, may lead to DNA damage, oxidative stress, and increased cancer risk. High intensities can also dehydrate tissue, cause pigmentation changes, and affect deeper layers, potentially damaging subcutaneous structures like nerves or muscles. The severity depends on the light’s wavelength, exposure duration, and skin type, with longer exposure or deeper-penetrating wavelengths increasing the risk of harm.

[0070] In some embodiments, the device further comprises a narrowband light source characterized by overlapping wavelength bands between of 380 to 830 nm.

[0071] According to one aspect of the present invention, there is provided a device comprising a hybrid light source capable of delivering both broadband and narrowband light spectra; wherein the hybrid light source enhances the versatility of the device. In some embodiments, the device is foruse in phototherapy. In some embodiments, the device is configured to induce an at least one photochemical reaction, and at least one photothermal process, or both. Non-limiting examples of phototherapy include but are not limited to light-induced cell growth acceleration, light-induced bacterial control, or pain relief, including any combination thereof.

[0072] In some embodiment, the HLS comprises an at least one white LED. In some embodiments, the at least one white LED is characterized by emitting wavelengths at between 400 nm to 800 nm. In some embodiments, the HLS further comprises an at least one additional emitter characterized by wavelength bands between of 380 to 830 nm. In some embodiments, the at least one additional emitter is characterized by a narrowband wavelength. A person skilled in the art would appreciate that choosing the at least one additional emitter depends on desired phototherapy, for example, blue light typically at 470 nm wavelength, keratin expression increases and improves wound healing via a nitric oxide (NO)-mitochondrial pathway.

[0073] In some embodiment, the HLS comprises an at least one white LED within the wavelength range of 400 to 800 nm, complemented by a subset of emitters comprising narrowband wavelength. In some embodiments, non-limiting examples of narrowband wavelength include but are not limited to blue light 405 nm-480 nm, red light at 630 nm- 680 nm, including any combination thereof.

[0074] In some embodiment, the HLS comprises an at least one white LEDs within the wavelength range of 400 to 800 nm, complemented by a subset of emitters comprising narrowband blue LEDs at 450 nm, red laser diodes at 650 nm, or both. A person skilled in the would appreciate that this arrangement facilitates simultaneous application, for example, light, facilitates light-induced cell growth acceleration (LCGA) and light-induced bacterial control (LBC), leveraging both the blue and red spectra.

[0075] In some embodiments, irradiation in each of the wavelength bands is activated either serially or in parallel.

[0076] In some embodiments, the device of the present invention, provides precise control over light delivery.

[0077] In some embodiment, the HLS comprises a plurality of LEDs arranged in a matrix configuration to maximize coverage of the treatment area. In some embodiments, the matrix comprises a combination of white LEDs and an at least one narrowband light array emitter strategically placedto achieve a uniform spectral distribution across the treatment surface. In some embodiments, the matrix configuration facilitates blending various wavelengths, offering a comprehensive light therapy solution adaptable for diverse clinical applications. As used herein, the term "plurality" refers the state of being more than one or multiple. For example, the phrase FILS comprises a plurality of LEDs refers to at least two LEDs. As used herein, the term " matrix" refers to an ordered arrangement of elements (objects, numbers, components, etc.) organized in rows and columns, forming a grid-like structure. In the context of LEDs, it describes how the LEDs are systematically positioned for specific functionalities.

[0078] In some embodiments, the device of the present invention further comprises a field-of-view (FOV) adapter with optical elements that ensure uniform light distribution across the treatment area. A person skilled in the art would appreciate that this design is versatile, and it enables the use of specialized optical components for focused applications.

[0079] Non-limiting examples of specialized optical components include but are not limited to lenses, mirrors, filters, prisms, polarizers, gratings, optical fibers, waveguides, coating, beam modifiers, detectors, sensors, specialized laser, optical aperture, optical chopper, optical circulator, waveplates, or light pipe equipped, including ay combination thereof.

[0080] In some embodiment, the device of the present invention further comprises a removable light pipe equipped with angled optical facets that channel light efficiently in enclosed spaces. A person skilled in the art would appreciate that this feature is advantageous in specialized phototherapy applications, such as the treatment of internal tissue lesions, where precise light guidance and distribution are critical for achieving desired therapeutic outcomes.

[0081] In another embodiment, the FOV adaptor utilizes a coupling mechanism that allows interchangeable optical elements, such as Fresnel lenses or parabolic reflectors, to be fitted according to specific clinical applications. A person skilled in the art would appreciate that this design enables the device to modify the spatial distribution of light, optimizing light delivery for concave or irregular treatment areas.

[0082] In another embodiment, the FOV adaptor incorporates a modular design comprising interchangeable optical elements, including but not limited to converging and diverging lenses. A person skilled in the art would appreciate that the interchangeable optical elements are selectedand swapped to modify focus and intensity profile of the emitted light, providing flexibility in delivering tailored therapy based on specific treatment protocols or patient needs.

[0083] In some embodiments, HLS irradiance is adjustable, and is between 10 mW / cm2and 500 mW / cm2In some embodiments, irradiance adjustment is made by varying electrical current inputs to each individual emitters, by varying the size of the irradiated area using the FOV adaptor, or both.

[0084] In some embodiments, the device, further comprises a current regulator designed to maintain a constant current through a load, regardless of changes in input voltage or load resistance, and enables precise control over light delivery. In some embodiments, the current regulator adjusts brightness and power of the emitters, allowing for a range of irradiance levels suitable for different treatment needs.

[0085] In another embodiment, the device further comprises a timer configured to regulate light exposure duration, enhance ability to manage treatment time and optimize therapeutic outcomes. In some embodiments, the timer is configured to limit the time duration and total incident power of the irradiation. In some embodiments, the device further comprises a temperature sensor, configured to work in conjunction with the current regulator to maintain consistent light intensity despite temperature changes.

[0086] In some embodiment, the timer is integrated with a programmable microcontroller that interfaces with the current regulator to automatically adjust light intensities according to pre-set treatment protocols. In some embodiments, the timer is configured to calibrate exposure durations, interpolates output power settings based on historical usage data, or ensure consistent therapeutic effectiveness across multiple sessions, including any combination thereof.

[0087] In some embodiments, the device of the present invention further comprises a correction circuit configured refine intensity outputs, thereby enhances the device functionality and adaptability. As used herein, the term "correction circuit" refers to electronic circuit designed to adjust, modify, or correct certain properties or characteristics of a signal or device to achieve the desired performance.

[0088] In some embodiment, the device of the present invention further comprises a temperature sensor near the HLS, configured to activate an alert upon detection of temperature deviations beyond a user-defined threshold. In some embodiments, activation of the alert, temporarily pauses orreduces output intensity, safeguarding the device's operational integrity, maintaining stability in therapeutic irradiation levels, or both.

[0089] In some embodiments, the device of the present invention further comprises a detachable power management module, configured to enhance the device adaptability, efficiency, and longevity, making it a highly versatile and future-proof solution for medical and therapeutic applications. A person skilled in the art would appreciate that if a device currently uses red and blue light for its treatment, but a newer treatment requires the addition of green emitters, the detachable power management module could be adjusted to deliver the correct voltage and current for the green emitters, thereby avoiding replacing or redesigning the entire device, ensuring a seamless upgrade.

[0090] In some embodiments, the device of the present invention further comprises a wireless interface configured to control remotely the device via a mobile application, a designated remote controller, or both. In some embodiments, the wireless interface enables practitioners to modify treatment parameters such as irradiance levels, treatment duration, and wavelength selection without direct contact with the device, thereby enhancing operational convenience and hygiene in clinical environments.

[0091] In an embodiment, the device of the present invention comprises a real-time feedback mechanism wherein tissue response is continuously monitored using integrated imaging sensors. In some embodiments collected data is processed to dynamically adjust irradiation parameters, ensuring optimal therapeutic outcomes while preventing tissue overexposure. In some embodiments, the real-time feedback is or comprises a machine learning algorithm configured to enhance the decision-making process for adaptive therapy management.

[0092] Reference is now made to FIG. 1 presenting a graph of the wavelength bands of an exemplary HLS, according to the invention. The horizontal axis denotes wavelength, in nm., and the vertical axis denotes intensity in arbitrary units (a.u ). In the embodiment of FIG 1, the band labelled W is typical of a white LED spectrum, which closely resembles the spectra of "true color" LEDs, generic LEDs, solar spectrum LEDs and halogen lamps with UV and IR filters. The drop-off in intensity below 400 nm. is sharp enough to avoid overexposure to ultraviolet (UV) irradiation which may be harmful at the power levels used for phototherapy.

[0093] One illumination source which may provide the broadband white spectrum of FIG. 1 is manufactured by PhosphorTech Corporation and is described in the web sitehttps: / / phosphortech.com / artificial-sun-by-solid-state-lighting / , entitled “Artificial Sun by Solid- State Lighting”. Using low-cost blue, violet, or ultraviolet (UV) LEDs, in conjunction with RadiantFlex™ phosphor sheets, PhosphorTech is able to produce custom LED’s that meet a range of broadband white spectrum specifications.

[0094] In the embodiment of FIG. 1, there are two additional narrow band emitters. One is a blue LED having an emission spectrum labelled B extending from 400 to 500 nm, with a peak intensity at about 450 nm. The other is a red LED having an emission spectrum labelled R extending from 600 to 700 nm., with a peak intensity at about 650 nm.

[0095] It is preferable that the currents into the red and blue emitters be regulated separately, so that the irradiation may consist of only blue light, only red light, or a mixture of both red and blue light. The precise mixture is regulated by the current regulator, in accordance with the type of phototherapy desired, e.g. LCGA, LBC, or light therapy to accelerate healing and anti-aging.

[0096] Reference is now made to FIG. 2 showing a block diagram of an HLS device 200, according to the invention. A power supply, which may be an AC or DC voltage supply, may be switched on or off by a timer, which is either manual or automatic. In FIG. 2, the time is shown as being controlled by a controller 205, which receives user input. A current regulator 210 transforms voltage to current, according to predetermined values needed by the emitter array 220. The emitters may be, for example, LDs or LEDs having the same or different central wavelengths. The bundle of electrical leads 215 provides a separate current for each emitter in array 220. The currents may be continuous or pulsed.

[0097] The light emitted by array 220 enters a FOV adaptor 230, which typically consists of optical lenses or mirrors that change the numerical aperture of the incident light. The emitted light irradiation enters a FOV which defines the spatial dimensions of the treatment area. As shown in FIG. 2, both the current regulator 210 and the FOV adaptor 230 are under the control of controller 205.

[0098] For better regulation of the irradiation intensity, an optional temperature sensor is provided to measure the ambient temperature in the proximity of emitter array 220. The measurements are fed back to current regulator 210, which adjusts the currents sent to the emitter array, in response to fluctuations in ambient temperature. This is especially important for white LEDs whose intensities are known to vary by as much as 2% for a 1 °C change in temperature.

[0099] In some embodiments, the HLS device includes a correction circuit and a correction LED, such as those disclosed in the abovementioned US patent number 11,490,479, in order to produce a selected spectral characteristic.

[0100] Reference is now made to FIG. 3 presenting an alternative FOV adaptor 330, which includes collimating optics and a light pipe 340, which may be either rigid or flexible. FOV adaptor 330 is especially suited for irradiating vaginal or oral lesions or wounds.

[0101] Reference is now made to FIG. 4 a block diagram of a method 400 of using the HLS device for phototherapy. The method consists of the following steps:410: Application of photosensitizer, nano- photosensitizer or photothermal material to a treatment area (if needed);420: Selection of treatment parameters, such as time duration, wavelength bands, emission intensities, and FOV;430: Inputting of the treatment parameters to the HLS controller;440: Activation of the irradiation (by the HLS controller or manually); and450: Termination of the irradiation (by the HLS controller or manually).

[0102] In some embodiments, the HLS device include an imaging sensor for tissue assessment, such as that disclosed in the abovementioned US patent number 11,471,696. In such embodiments, the termination of the irradiation in step 450 may be triggered by a signal from the imaging sensor, indicating that a desired condition of the tissue surface has been reached.

[0103] According to another aspect of the present invention there is provided a method for photo-treating a disease, a disorder or a condition in a subject in need thereof; comprising: (i) exposing subject tissue to the a phototherapy device; (ii) selecting treatment parameters comprising duration and wavelength bands; (iii) irradiating the tissue with a light source at suitable condition; and (iv) concluding irradiation at the end of the treatment session wherein the light source comprises an at least one white light-emitting diode (LED). In some embodiments, the white LED is configured to emit homogenized light intensity at all wavelengths within the visible range, 400 to 800 nm.

[0104] In some embodiments, the light source further comprises an at least one narrow band emitter. In some embodiments, the at least one narrow band emitter is narrow band configured to emit light in an overlapping wavelength range of 380 to 830 nm.

[0105] In some embodiments, the light source comprises an array of emitters.

[0106] According to another aspect of the present invention there is provided a method for photo-treating a disease, a disorder or a condition in a subject in need thereof; comprising: (i) exposing subject tissue to the a phototherapy device; (ii) selecting treatment parameters comprising duration and wavelength bands; and (iii) irradiating the tissue with a hybrid light source (HLS) at suitable condition; wherein the, HLS comprises an at least one white light-emitting diode (LED) and an at least one narrow band emitter. In some embodiments, the white LED is configured to emit homogenized light intensity at all wavelengths within the visible range, 400 to 800 nm. In some embodiments, the at least one narrow band emitter is narrow band configured to emit light in an overlapping wavelength range of 380 to 830 nm.

[0107] In some embodiments, HLS comprises an array of emitters, the emitters.

[0108] In some embodiments, the phototherapy device further comprises a sensor feedback and real-time tissue condition assessments thereby automatic initiation and / or cessation of therapy is obtained.

[0109] In some embodiments, the disease, disorder or condition is selected from the group consisting of skin condition, bilirubin reduction, seasonal affective disorder, major depressive disorder, circadian rhythm disorder, wound healing, muscle recovery, chronic pain management, dry eye syndrome, hair loss, anti-aging, allergies, or sleep disorder, including any combination thereof.

[0110] In some embodiments, skin condition is selected from the group consisting of psoriasis, eczema, vitiligo, acne, or pre-cancerous lesions, blisters, ulcers, including any combination thereof.

[0111] In some embodiments, suitable condition refers to irradiation time, intensity (W / cm2), and wavelength. In some embodiments, irradiation is between 1 min to 20 min, between 1 mm to 1 Omin, between 1 min to 5 min, or between 1 min and 15 min, including any value or range in between. In some embodiments, irradiation is conducted at least once a week, every five days, every four days, every three days, every two days, once a day, twice a day, or three times a day, including any range or combination thereof.

[0112] In some embodiments, irradiation is adjustable. In some embodiments, irradiation intensity is between 10 mW / cm2and 500 mW / cm2. In some embodiments, irradiation occurs at a wave length between 380 nm and 830 nm. A person skilled in the art that the exact parameters used in each treatment depends on the condition, disorder or disease treated, and its severity.

[0113] As used herein, the term “subject” refers to any subject, including a mammalian subject, for whom therapy is desired, for example, a human.

[0114] In some embodiments, the subject is a human subject.EXAMPLE

[0115] A phototherapy device comprising a white light-emitting diode configured to emit a homogenized wave length between 400 nm to 800 nm, according to some embodiments of the present invention was used to treat subjects with different skin conditions.Example 1 - Wound healing

[0116] The inventors examined the healing of a wound 500 in a subject having diabetic. The subject had wound 500 for over a month, after treating wound 500 with the device of the present invention, by exposing wound 500 to an intensity of 100 mW / cm2, for 10 minutes twice a day for 10 days, a scab was formed 510. It is clearly seen from FIG. 5A and 5B that the wound has been closed after 10 days of treatment.Example 2 - Anti-aging and scaring

[0117] The inventors examined the effect the treatment has on the skin: the effect of treatment has on (a) the face firmness, and wrinkles; and (b) post acne scaring. a. Anti- Aging

[0118] The wrinkle lines around the mouth and chin were evaluated after subjecting them to the device of the invention according to some embodiments of the invention. FIG. 6A demonstrates a wrinkle fine line around the mouth, 600A and the chin fine line 610A, and FIG. 6B shows the wrinkled fine line around the mouth and chin fine line after treatment, 600B and 610B, respectively. The skin was exposed to an intensity of 100 mW / cm2, once a day, for 10 minutes, for a week. The wrinkle line near the mouth has visibly faded by at least 50% following the treatment, indicatingan improvement in skin texture and reduction in wrinkle depth. In addition, the chin fine line seems firmer as if it was lifted. b. Post acne scaring

[0119] The skin was exposed to an intensity of 100 mW / cm2, once every two days, for 10 minutes, for a week, and the reduction of scaring was examined before (FIG. 7A) and after (FIG. 7B) treatment. Surprisingly, only after three treatments a reeducation in the scaring depth has been observed after treatment, in area 700, when it was compared (700A before treatment, 700B after treatment).

[0120] The descriptions of the various embodiments of the present disclosure have been presented for purposes of illustration but are not intended to be exhaustive. Many other modifications and variations will be apparent to those of ordinary skill in the art without departing from the scope and spirit of the described embodiments. The terminology used herein was chosen to best explain the principles of the embodiments, the practical application or technical improvement over technologies found in the marketplace, or to enable others of ordinary skill in the art to understand the embodiments disclosed herein.

Claims

ClaimsWhat is claimed is:

1. A device comprising an at least one white light-emitting diode (LED), wherein said white LED emits homogenized light intensity at all wavelengths within the visible range 400 to 800 nm.

2. The device of claim 1 , wherein said at least one white LED characterized by an intensity from 10 mW / cm2to 500 mW / cm23. The device of claim 1, wherein a plurality of said at least one white LED form an array emitter.

4. The device of any of claims 1 to 3, further comprising an at least one narrow band emitter, configured to emit light in an overlapping wavelength range of 380 to 830 nm.

5. The device of any of claims 1 to 4, further comprising a current regulator configured to adjust said emitters, intensity or both.

6. The device of any of claims 1 to 5, further comprising a field-of-view (FOV) adaptor configured to distribute emitted light uniformly across a treatment area.

7. The device of claim 6, wherein said FOV adaptor comprises a light pipe for application in specialized treatment areas.

8. The device of any of claims 1 to 7, further comprising a timer configured to control light exposure duration.

9. The device of any of claims 1 to 8, further comprising a temperature sensor configured to adjust current inputs to maintain consistent intensity from said white LED.

10. The device of any of claims 1 to 9, is for use in phototherapy of a disease, a disorder or condition in a subject in need thereof.

11. The device of claim 10, wherein said disease, said disorder or said condition is selected from the group consisting of skin condition, bilirubin reduction, seasonal affective disorder, circadian rhythm disorder, wound healing, muscle recovery, oral mucositis, chronic pam management, hair loss, anti-aging, allergies, including any combination thereof.

12. A method for photo-treating a disease, a disorder or condition in a subject in need thereof, said method comprising:a. exposing subject tissue to said phototherapy device; b. selecting treatment parameters comprising duration, wavelength bands and intensity; and c. irradiating said tissue with an at least one emitter at suitable condition; wherein said at least one emitter comprising a white light- emitting diode (LED) characterized by emitting homogenised light intensity at a all wavelength within the visible range, range of 400 to 800 nm.

13. The method of claim 12, wherein said at least one white LED is characterized by an intensity from 10 mW / cm2, to 500 mW / cm2.

14. The method of claim 12 or 13, wherein a plurality of said at least one emitter form an array emitter.

15. The method of any of claims 12 to 14, further comprising an at least one narrow band emitter, configured to emit light in an overlapping wavelength range of 380 to 830 nm.

16. The method of any of claims 12 to 15, wherein said initiation is controlled manually, automatically, or both.

17. The method of claim 16, wherein said automatically controlled is by sensor feedback.

18. The method of any of claims 12 to 17, wherein said phototherapy device further comprises a correction circuit configured to refine spectral outputs.

19. The method of any of claims 12 to 18, wherein said phototherapy device further comprises and imaging sensor configured to assess tissue conditions in real time during irradiation.

20. A device comprising a hybrid light source (HLS) wherein said HLS comprises an at least one white light-emitting diode (LED) and an at least one narrow band emitter at an array of emitters.

21. The device of claim 20, wherein said at least one white LED is configured to emit light at a wavelength range of 400 to 800 nm.

22. The device of claims 20 or 21, wherein said at least one white LED characterized by an intensity from 10 mW / cm2to 500 mW / cm2.

23. The device of any of claims 20 to 22, wherein a plurality of said at least one white LED form an array emitter.

24. The device of claim 20, wherein said at least one narrow band emitter is configured to emit light in an overlapping wavelength range of 380 to 830 nm.

25. The device of any of claims 20 to 24, further comprising a current regulator configured to adjust said emitters, intensity or both.

26. The device of any of claims 20 to 25, further comprising a field-of-view (FOV) adaptor configured to distribute emitted light uniformly across a treatment area.

27. The device of claim 26, wherein said FOV adaptor comprises a light pipe for application in specialized treatment areas.

28. The device of any of claims 20 to 27, further comprising a timer configured to control light exposure duration.

29. The device of any of claims 20 to 28, further comprising a temperature sensor configured to adjust current inputs to maintain consistent intensity from said HLS.

30. The device of any of claims 20 to 29, is for use in phototherapy of a disease, a disorder or condition in a subject in need thereof.

31. The device of claim 30, wherein said disease, said disorder or said condition is selected from the group consisting of skin condition, bilirubin reduction, seasonal affective disorder, circadian rhythm disorder, wound healing, muscle recovery, oral mucositis, chronic pain management, hair loss, anti-aging, allergies, including any combination thereof.

32. A method for photo-treating a disease, a disorder or a condition in a subject in need thereof; comprising:(i) exposing subject tissue to said phototherapy device;(ii) selecting treatment parameters comprising duration and wavelength bands; and(iii) irradiating said tissue with HLS at suitable condition; wherein said HLS comprises an at least one white LED and an at least one narrow band emitter.

33. The method of claim 32, wherein said white LED is configured to emit homogenized light intensity at all wavelengths within the visible range, 400 to 800 nm.

34. The method of claim 32 or 33, wherein said an at least one white LED is characterized by an intensity from 10 mW / cm2, to 500 mW / cm2.

35. The method of claim 32, wherein said at least one narrow band emitter is narrow band configured to emit light in an overlapping wavelength range of 380 to 830 nm.

36. The method of claim 32, wherein HLS is in a form of an array.

37. The method of any of claims 32 to 36, wherein said initiation is controlled manually, automatically, or both.

38. The method of claim 37, wherein said automatically controlled is by sensor feedback.

39. The method of any of claims 32 to 38, wherein said phototherapy device further comprises a correction circuit configured to refine spectral outputs.

40. The method of any of claims 32 to 39, wherein said phototherapy device further comprises and imaging sensor configured to assess tissue conditions in real time during irradiation.

Images