Intraocular lens delivery apparatus and preparation method therefor

Abstract

The present invention relates to an ophthalmic medical implant material, and disclosed are an intraocular lens delivery apparatus and a preparation method therefor. The surface of the delivery apparatus is provided with a lubrication coating. A monomer forming the lubrication coating comprises at least one double bond for triggering polymerization on the surface of the delivery apparatus, and comprises at least one lubrication group for endowing the delivery apparatus with good lubrication properties. In the present invention, the lubrication coating is covalently bonded to the surface of the intraocular lens delivery apparatus. The coating can tolerate common sterilization methods such as moist heat sterilization and ethylene oxide sterilization, endows the delivery apparatus with a good lubrication effect, and improves the smoothness of intraocular lens implantation.

Description

Artificial lens delivery device and preparation method thereof Technical Field

[0001] The present invention relates to the technical field of ophthalmic medical implant materials, in particular to an artificial lens delivery device and a preparation method thereof. Background Art

[0002] Intraocular lens (IOL) implantation is an effective treatment for a variety of ophthalmic conditions, including cataracts and refractive errors. Currently, IOL delivery devices are primarily made of materials such as polypropylene, polycarbonate, and cycloolefin copolymer. These materials create significant frictional resistance with the IOL during delivery, resulting in high injection forces, making it difficult to push, and potentially damaging the IOL or the delivery device, leading to implant failure. Lubricating the surface of IOL delivery device materials can effectively reduce IOL delivery resistance and improve the operability and safety of IOL implantation.

[0003] Chinese invention patent CN101455861A discloses a method for preparing a lubricating coating on the surface of a medical catheter polymer material. This patent pre-treats the surface of the medical catheter polymer material to form hydrophilic adsorption sites, then immerses the site in a lubricating coating precursor solution for adsorption. Finally, a grafting reaction produces a medical catheter with a lubricating coating. The lubricating coating precursor solution in this patent is a copolymer or hydrogel solution, which can only form limited binding sites with the substrate during the grafting reaction, resulting in limited adhesion of the final coating. Furthermore, additives such as castor oil, benzophenone, persulfate, and benzoyl peroxide are required, complicating the precursor solution formulation and increasing the risk of harmful residual substances in the coating. Summary of the Invention

[0004] In view of the deficiencies in the prior art, the present invention solves the problems of the lubricating coating prepared by the prior art having insufficient bonding strength with the substrate, resulting in easy detachment of the coating and introduction of harmful substances.

[0005] In view of the above technical problems, the object of the present invention is to provide an intraocular lens delivery device and a preparation method thereof.

[0006] The present invention induces a surface polymerization reaction through irradiation, and covalently bonds the lubricating coating to the surface of the intraocular lens delivery device, so that the device has good lubrication performance, reduces the resistance to intraocular lens implantation, and improves the operability and safety of implantation.

[0007] The specific contents are as follows:

[0008] First, the present invention provides an intraocular lens delivery device, the surface of which is provided with a lubricating coating;

[0009] The monomers forming the lubricating coating include a mixture of one or more of acrylic acid, methacrylic acid, acrylamide, methacrylamide, 2-methacryloyloxyethyl phosphorylcholine, methacryloylethyl sulfobetaine, hydroxyethyl methacrylate, hydroxyethyl acrylate, vinyl pyrrolidone, polyethylene glycol methacrylate, polyethylene glycol acrylate, 2-acrylamido-2-methylpropanesulfonic acid, N-hydroxymethyl acrylamide, dimethyl acrylamide, N-(2-hydroxyethyl) acrylamide, N-(hydroxymethyl) acrylamide, N-acryloyl(trihydroxymethyl)aminomethane, N-(2-amino-2-oxoethyl) acrylamide, N-(2-aminoethyl) methacrylamide hydrochloride, 2-aminoethyl ester hydrochloride, and N-(3-aminopropyl) methacrylamide hydrochloride.

[0010] Second, the present invention provides a method for preparing an intraocular lens delivery device, comprising the following steps:

[0011] (1) Pre-processing the material of the intraocular lens delivery device to obtain a first processed body;

[0012] (2) immersing the first treated body in a lubricating monomer solution to obtain a second treated body;

[0013] (3) The second treated body is irradiated to induce polymerization, thereby obtaining an intraocular lens delivery device with a lubricating coating on the surface.

[0014] The present invention introduces appropriate surface pretreatment based on the material type of the delivery device; and uses irradiated surface to initiate free radical polymerization, and connects polymers with lubricating properties to the surface of the intraocular lens delivery device through covalent bonds, thereby obtaining an intraocular lens delivery device with good coating adhesion and compatible with sterilization methods such as wet heat and epoxy.

[0015] In the present invention, in step (1), the pretreatment includes one or more combinations of plasma treatment, alkali solution treatment, acid solution treatment, chromium pickling solution treatment, cleaning, sodium naphthalene treatment, and irradiation treatment.

[0016] In the present invention, in step (2), the solvent in the lubricating monomer solution includes one or more of water, acetone, ether, formic acid, acetic acid, N'N-dimethylformamide, dimethyl sulfoxide, N'N-dimethylacetamide, methanol, ethanol, isopropanol, n-butanol, dichloromethane, chloroform, tetrahydrofuran, dioxane, n-hexane, cyclohexane, hexafluoroisopropanol, toluene, petroleum ether, acetonitrile, and ethyl acetate.

[0017] In the present invention, in step (3), the irradiation method includes one or more combinations of light, X-rays, α-rays, β-rays, γ-rays, and electron beams.

[0018] In the present invention, the material of the intraocular lens delivery device includes a mixture or copolymer of one or more of polypropylene, polyethylene, polycarbonate, polyurethane, polyamide, polyethylene terephthalate, cycloolefin copolymer, polyvinyl chloride, polymethylpentene, polystyrene, polyetheretherketone, fluoropolymer or polyether block polyamide.

[0019] Further preferred intraocular lens delivery device materials also include pre-treated polypropylene intraocular lens delivery device materials.

[0020] The preparation method of the pretreated polypropylene intraocular lens delivery device material is as follows:

[0021] The polypropylene intraocular lens delivery device material is washed with acetone for 5 to 15 minutes, and then placed in a mixed solution at a weight ratio of 1:3 to 8 for thermal oxidation treatment at 90 to 98°C for 10 to 30 minutes. After the thermal oxidation treatment, it is washed with cold water for 3 to 7 times, and then washed with 50 to 70°C water until the pH value of the washing solution reaches neutral, and then dried until a constant weight is reached to obtain a pretreated polypropylene intraocular lens delivery device material.

[0022] The solvent of the mixed solution is water, and the solute is at least one of ammonium persulfate, nitric acid, ammonium dihydrogen phosphate, chromium trioxide, sulfuric acid, and phosphoric acid.

[0023] The functions of each substance are as follows:

[0024] Acetone was used to wash the polypropylene intraocular lens delivery device material, likely to remove impurities and dirt and prepare the surface for subsequent processing.

[0025] Mixed solution: A mixed solution containing ammonium persulfate, nitric acid, and ammonium dihydrogen phosphate in water is used for thermal oxidation of polypropylene intraocular lens delivery device materials. Ammonium persulfate may act as an oxidant, nitric acid may provide an acidic environment, and ammonium dihydrogen phosphate may provide phosphate ions. This thermal oxidation treatment may chemically alter the surface of the polypropylene intraocular lens delivery device material, such as introducing hydroxyl (-OH) and carbonyl (C=O) functional groups, improving its hydrophilicity and adhesion properties.

[0026] Cold water was used to wash the thermally oxidized polypropylene intraocular lens delivery device material to remove residual treatment agents and products.

[0027] A 2-methacryloyloxyethyl phosphorylcholine / water solution is used to soak the polypropylene intraocular lens delivery device material, which has been thermally oxidized and washed. The solution is cycled through a vacuum and nitrogen atmosphere multiple times, followed by electron beam irradiation polymerization. This step allows the 2-methacryloyloxyethyl phosphorylcholine / water solution monomer to polymerize on the material surface, forming covalent bonds that bind the lubricating coating to the intraocular lens delivery device material and improve the coating's adhesion.

[0028] Deionized water was used to wash the radiation-polymerized IOL delivery device material to remove residual monomers and other impurities.

[0029] In summary, the combination of these substances and steps is used to improve the hydrophilicity and adhesion properties of the surface of the intraocular lens delivery device material and introduce a coating with a lubricating function, thereby achieving a good lubrication effect.

[0030] Compared with the prior art, the present invention has the following beneficial effects:

[0031] 1) The present invention uses radiation to initiate surface polymerization of monomers, and bonds the lubricating coating to the intraocular lens delivery device through covalent bonds, which can effectively improve the bonding strength between the coating and the substrate and prevent the coating from falling off during the delivery of the intraocular lens;

[0032] 2) The present invention introduces appropriate surface pretreatment based on the material type of the delivery device to further improve the bonding strength between the coating and the substrate, and at the same time will help improve the efficiency of monomer initiation polymerization;

[0033] 3) The present invention combines the lubricating coating with the intraocular lens delivery device via a covalent bond, which can effectively improve the coating's ability to withstand sterilization methods such as moist heat sterilization and epoxy sterilization, so that its lubricating effect remains essentially unchanged after sterilization;

[0034] 4) The lubricating monomer solution of the present invention comprises only monomers and solvents, which can effectively eliminate harmful substances in the reaction and improve the biocompatibility of the intraocular lens delivery device;

[0035] 5) The present invention utilizes cheap, clean, and safe surface irradiation-induced polymerization technology to covalently bond a lubricating coating to the surface of the intraocular lens delivery device. The method and technology used are safe, economical, and conducive to large-scale production. BRIEF DESCRIPTION OF THE DRAWINGS

[0036] FIG1 shows the water contact angles of the polypropylene intraocular lens delivery device material of Example 1 before and after lubrication treatment, after flushing with deionized water for 24 hours after lubrication treatment, and after flushing with deionized water for 24 hours after lubrication treatment and then wet heat sterilization at 120° C. for 30 minutes;

[0037] Figure 2 shows the injection force of the polypropylene intraocular lens delivery device of Example 1 before and after lubrication treatment, after flushing with deionized water for 24 hours after lubrication treatment, and after flushing with deionized water for 24 hours after lubrication treatment and then wet heat sterilization at 120°C for 30 minutes. DETAILED DESCRIPTION

[0038] To make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention are described clearly and completely below. Where specific conditions are not specified in the embodiments, conventional conditions or conditions recommended by the manufacturer are used. Where the manufacturer of the reagents or instruments is not specified, all are conventional products that can be purchased commercially.

[0039] Main sources of substances:

[0040] Polypropylene intraocular lens delivery device material: Polypropylene raw material was purchased from Yihongdi New Materials Technology (Shanghai) Co., Ltd., brand: SFC-750R, and was prepared using conventional injection molding process.

[0041] Polycarbonate intraocular lens delivery device material: Polycarbonate raw material was purchased from Ningbo Jiayi New Material Technology Co., Ltd., brand: PC-1220, and was prepared using conventional injection molding process.

[0042] Cyclic olefin copolymer intraocular lens delivery device material: Cyclic olefin copolymer was purchased from Dongguan Yiyuan Plastic Raw Materials Co., Ltd., brand: APL5514ML, and was prepared using conventional injection molding process.

[0043] Fluoropolymer intraocular lens delivery device material: Fluoropolymer was purchased from Dongguan Shuangbang Plastic Raw Materials Co., Ltd., brand: FFR 550, and was prepared using conventional injection molding process.

[0044] Sodium naphthalene treatment liquid: Zhenjiang Hongke Rubber & Plastic Co., Ltd., item number: 020.

[0045] Technical solution:

[0046] First, the present invention provides an intraocular lens delivery device, the surface of which is provided with a lubricating coating;

[0047] Monomers forming lubricating coatings, including

[0048] In the present invention, the monomers of the lubricating coating include acrylic acid, methacrylic acid, acrylamide, methacrylamide, 2-methacryloyloxyethyl phosphorylcholine, methacryloylethyl sulfobetaine, hydroxyethyl methacrylate, hydroxyethyl acrylate, vinyl pyrrolidone, polyethylene glycol methacrylate, polyethylene glycol acrylate, 2-acrylamido-2-methylpropanesulfonic acid, N-hydroxymethyl acrylamide, dimethyl acrylamide, N-(2-hydroxyethyl) acrylamide, N-(hydroxymethyl) acrylamide, N-acryloyl (trihydroxymethyl) aminomethane, N-(2-amino-2-oxoethyl) acrylamide, N-(2-aminoethyl) methacrylamide hydrochloride, 2-aminoethyl ester hydrochloride, and a mixture of one or more of N-(3-aminopropyl) methacrylamide hydrochloride.

[0049] Second, the present invention provides a method for preparing an intraocular lens delivery device, comprising the following steps:

[0050] (1) Pre-processing the material of the intraocular lens delivery device to obtain a first processed body;

[0051] (2) immersing the first treated body in a lubricating monomer solution to obtain a second treated body;

[0052] (3) The second treated body is irradiated to induce polymerization, thereby obtaining an intraocular lens delivery device with a lubricating coating on the surface.

[0053] The present invention introduces appropriate surface pretreatment based on the material type of the delivery device; and uses irradiated surface to initiate free radical polymerization, and connects polymers with lubricating properties to the surface of the intraocular lens delivery device through covalent bonds, thereby obtaining an intraocular lens delivery device with good coating adhesion and compatible with sterilization methods such as wet heat and epoxy.

[0054] In the present invention, in step (1), the pretreatment includes one or more combinations of plasma treatment, alkali solution treatment, acid solution treatment, chromium pickling solution treatment, cleaning, sodium naphthalene treatment, and irradiation treatment.

[0055] In the present invention, in step (2), the solvent in the lubricating monomer solution includes one or more of water, acetone, ether, formic acid, acetic acid, N'N-dimethylformamide, dimethyl sulfoxide, N'N-dimethylacetamide, methanol, ethanol, isopropanol, n-butanol, dichloromethane, chloroform, tetrahydrofuran, dioxane, n-hexane, cyclohexane, hexafluoroisopropanol, toluene, petroleum ether, acetonitrile, and ethyl acetate.

[0056] In the present invention, in step (3), the irradiation method includes one or more combinations of light, X-rays, α-rays, β-rays, γ-rays, and electron beams.

[0057] In the present invention, the material of the intraocular lens delivery device includes a mixture or copolymer of one or more of polypropylene, polyethylene, polycarbonate, polyurethane, polyamide, polyethylene terephthalate, cycloolefin copolymer, polyvinyl chloride, polymethylpentene, polystyrene, polyetheretherketone, fluoropolymer or polyether block polyamide.

[0058] Third, the present invention provides an intraocular lens delivery device obtained by the aforementioned preparation method.

[0059] In the present invention, the surface contact angle of the lubricating coating of the obtained intraocular lens delivery device is 0-80 degrees.

[0060] Example 1

[0061] This embodiment provides a method for preparing an intraocular lens delivery device, comprising:

[0062] (1) subjecting the surface of the polypropylene intraocular lens delivery device material to low-temperature plasma treatment at a voltage of 70 V for 1.5 minutes to obtain a pretreated intraocular lens delivery device material;

[0063] (2) preparing a 10 wt% 2-methacryloyloxyethyl phosphorylcholine / water solution; placing the pretreated intraocular lens delivery device material obtained in step (1) in the 2-methacryloyloxyethyl phosphorylcholine / water solution at a weight ratio of 1:5, evacuating and then passing nitrogen, cycling for 3 times, and then placing under electron beam irradiation for polymerization for 3 hours, with an irradiation dose of 10 kGy;

[0064] (3) The intraocular lens delivery device material obtained in step (2) is taken out and washed with deionized water 5 times to obtain an intraocular lens delivery device with good lubrication effect.

[0065] Example 2

[0066] This embodiment provides a method for preparing an intraocular lens delivery device, comprising:

[0067] (1) soaking a polycarbonate intraocular lens delivery device material in a 10 wt % sodium hydroxide aqueous solution at a weight ratio of 1:5 for 1 hour to obtain a pretreated intraocular lens delivery device material;

[0068] (2) preparing a 15 wt % polyethylene glycol methyl ether methacrylate / water solution with a molecular weight of 2000; placing the pretreated intraocular lens delivery device material obtained in step (1) in the polyethylene glycol methyl ether methacrylate / water solution with a molecular weight of 2000 at a weight ratio of 1:5, bubbling with argon for 30 minutes, and then irradiating the solution under gamma rays for 1 hour with an irradiation dose of 10 kGy;

[0069] (3) The intraocular lens delivery device material obtained in step (2) is taken out and washed with deionized water 5 times to obtain an intraocular lens delivery device with good lubrication effect.

[0070] Example 3

[0071] This embodiment provides a method for preparing an intraocular lens delivery device, comprising:

[0072] (1) The polypropylene intraocular lens delivery device material was immersed in a 10 wt% benzophenone / ethanol solution at a weight ratio of 1:5 and bubbled with argon for 30 min. The solution was then placed under an intensity of 20 mW / cm 2 , irradiated under ultraviolet light with a wavelength of 365 nm for 20 min, and washed with ethanol three times to obtain the pretreated intraocular lens delivery device material;

[0073] (2) preparing a 20 wt% N-vinyl pyrrolidone / ethanol solution; placing the pretreated intraocular lens delivery device material obtained in step (1) in the N-vinyl pyrrolidone / ethanol solution at a weight ratio of 1:5, bubbling argon for 30 minutes, and then placing the solution at an intensity of 15 mW / cm 2 , irradiate under ultraviolet light with a wavelength of 365nm for 20min;

[0074] (3) The intraocular lens delivery device material obtained in step (2) is taken out and washed with ethanol five times to obtain an intraocular lens delivery device with good lubrication effect.

[0075] Example 4

[0076] This embodiment provides a method for preparing an intraocular lens delivery device, comprising:

[0077] (1) ultrasonically cleaning the cyclic olefin copolymer intraocular lens delivery device material with ethanol and acetone three times in sequence to obtain a pretreated intraocular lens delivery device material;

[0078] (2) preparing a 15% acrylamide / butanol solution; placing the pretreated intraocular lens delivery device material obtained in step (1) in the acrylamide / butanol solution at a weight ratio of 1:5, evacuating the solution and then passing nitrogen gas for three cycles, and then subjecting the solution to X-ray irradiation for polymerization for 10 minutes at a dose of 50 kGy;

[0079] (3) The intraocular lens delivery device material obtained in step (2) was taken out, washed with butanol three times, and then washed with ethanol three times to obtain an intraocular lens delivery device with good lubrication effect.

[0080] Example 5

[0081] This embodiment provides a method for preparing an intraocular lens delivery device, comprising:

[0082] (1) Soaking the fluoropolymer intraocular lens delivery device material in a sodium naphthalene treatment solution for 1 minute to obtain a pretreated intraocular lens delivery device material;

[0083] (2) preparing a hexafluoroisopropanol mixed solution containing 7 wt% of hydroxyethyl methacrylate and 7 wt% of acrylic acid; placing the pretreated intraocular lens delivery device material obtained in step (1) in the hydroxyethyl methacrylate / acrylic acid / hexafluoroisopropanol mixed solution at a weight ratio of 1:5, bubbling nitrogen for 30 minutes, and then placing it under electron beam irradiation for polymerization for 3 hours at an irradiation dose of 15 kGy;

[0084] (3) The intraocular lens delivery device material obtained in step (2) was taken out, washed with ethanol three times, then soaked in a 10% sodium carbonate aqueous solution overnight, and washed with deionized water three times to obtain an intraocular lens delivery device with good lubrication effect.

[0085] Example 6

[0086] This embodiment provides a method for preparing an intraocular lens delivery device, comprising:

[0087] (1) subjecting the surface of the pretreated polypropylene intraocular lens delivery device material to low-temperature plasma treatment at a voltage of 70 V for 1.5 minutes to obtain a pretreated intraocular lens delivery device material;

[0088] (2) preparing a 10 wt% 2-methacryloyloxyethyl phosphorylcholine / water solution; placing the pretreated intraocular lens delivery device material obtained in step (1) in the 2-methacryloyloxyethyl phosphorylcholine / water solution at a weight ratio of 1:5, evacuating and then passing nitrogen, the cycle was repeated three times, and then irradiated under an electron beam for 3 hours with an irradiation dose of 10 kGy;

[0089] (3) The intraocular lens delivery device material obtained in step (2) is taken out and washed with deionized water 5 times to obtain an intraocular lens delivery device with good lubrication effect.

[0090] The preparation method of the pretreated polypropylene intraocular lens delivery device material is as follows:

[0091] The polypropylene intraocular lens delivery device material was washed with acetone for 10 minutes, and then placed in a mixed solution at a weight ratio of 1:5 for thermal oxidation treatment at 95°C for 20 minutes. The mixed solution solvent was water, containing 0.4 mol / L ammonium persulfate, 7 mol / L nitric acid, and 6.5 mol / L ammonium dihydrogen phosphate. After the thermal oxidation treatment, it was washed with cold water 5 times and then washed with 60°C water until the pH value of the washing solution reached 7. It was then dried until a constant weight was reached to obtain a pretreated polypropylene intraocular lens delivery device material.

[0092] Comparative Example 1

[0093] The preparation method of an intraocular lens delivery device is basically the same as that of Example 6, the only difference being the preparation method of the pretreated polypropylene intraocular lens delivery device material.

[0094] The preparation method of the pretreated polypropylene intraocular lens delivery device material is as follows:

[0095] The polypropylene intraocular lens delivery device material was washed with acetone for 10 minutes, and then placed in a mixed solution with a weight ratio of 1:5 for thermal oxidation treatment at 95°C for 20 minutes. The mixed solution solvent was water, containing 0.4 mol / L chromium trioxide, 7 mol / L nitric acid, and 6.5 mol / L ammonium dihydrogen phosphate. After the thermal oxidation treatment, it was washed with cold water 5 times and then washed with 60°C water until the pH value of the washing solution reached 7. It was then dried until a constant weight was reached to obtain a pretreated polypropylene intraocular lens delivery device material.

[0096] Comparative Example 2

[0097] The preparation method of an intraocular lens delivery device is basically the same as that of Example 6, the only difference being the preparation method of the pretreated polypropylene intraocular lens delivery device material.

[0098] The preparation method of the pretreated polypropylene intraocular lens delivery device material is as follows:

[0099] The polypropylene intraocular lens delivery device material was washed with acetone for 10 minutes, and then placed in a mixed solution with a weight ratio of 1:5 for thermal oxidation treatment at 95°C for 20 minutes. The mixed solution solvent was water, containing 0.4 mol / L ammonium persulfate, 7 mol / L sulfuric acid, and 6.5 mol / L ammonium dihydrogen phosphate. After the thermal oxidation treatment, it was washed with cold water 5 times and then washed with 60°C water until the pH value of the washing solution reached 7. It was then dried until a constant weight was reached to obtain a pretreated polypropylene intraocular lens delivery device material.

[0100] Comparative Example 3

[0101] The preparation method of an intraocular lens delivery device is basically the same as that of Example 6, the only difference being the preparation method of the pretreated polypropylene intraocular lens delivery device material.

[0102] The preparation method of the pretreated polypropylene intraocular lens delivery device material is as follows:

[0103] The polypropylene intraocular lens delivery device material was washed with acetone for 10 minutes, and then placed in a mixed solution with a weight ratio of 1:5 for thermal oxidation treatment at 95°C for 20 minutes. The mixed solution solvent was water, containing 0.4 mol / L ammonium persulfate, 7 mol / L nitric acid, and 6.5 mol / L phosphoric acid. After the thermal oxidation treatment, it was washed with cold water 5 times and then washed with 60°C water until the pH value of the washing solution reached 7. It was then dried until a constant weight was reached to obtain a pretreated polypropylene intraocular lens delivery device material.

[0104] Comparative Example 4

[0105] The preparation method of an intraocular lens delivery device is basically the same as that of Example 6, the only difference being the preparation method of the pretreated polypropylene intraocular lens delivery device material.

[0106] The preparation method of the pretreated polypropylene intraocular lens delivery device material is as follows:

[0107] The polypropylene intraocular lens delivery device material was washed with acetone for 10 minutes, and then placed in a mixed solution at a weight ratio of 1:5 for thermal oxidation treatment at 95°C for 20 minutes. The mixed solution solvent was water, containing 0.4 mol / L chromium trioxide, 7 mol / L sulfuric acid, and 6.5 mol / L phosphoric acid. After the thermal oxidation treatment, the material was washed with cold water 5 times and then washed with 60°C water until the pH value of the washing solution reached 7. It was then dried until a constant weight was reached to obtain a pretreated polypropylene intraocular lens delivery device material.

[0108] Test Example 1

[0109] Contact angle tests were performed on the intraocular lens delivery device materials prepared in the embodiments of the present invention and the comparative examples before and after lubrication treatment, after flushing with deionized water for 24 hours after lubrication treatment, and after flushing with deionized water for 24 hours after lubrication treatment and then wet heat sterilization at 120°C for 30 minutes; the test results are shown in Table 1.

[0110] Table 1 Water contact angle test results

[0111] Test Example 2

[0112] Experiments were conducted on samples of the intraocular lens delivery device materials prepared in the embodiments of the present invention and the comparative examples. The obtained delivery device materials were rinsed with deionized water for 24 hours and sterilized with wet heat at 120°C for 30 minutes. Then, the injection force test of the intraocular lens with a delivery optical power of 28.0 was performed. The test results are shown in Table 2.

[0113] Table 2 Injection force test results

[0114] Example 6 of the present invention has a lower water contact angle and a lower injection force, which may be due to the pretreatment method used in this embodiment including subjecting the polypropylene intraocular lens delivery device material to thermal oxidation treatment, and the mixed solution used contains ammonium persulfate, nitric acid and ammonium dihydrogen phosphate. It can improve the surface hydrophilicity, and the thermal oxidation acid treatment using ammonium persulfate, nitric acid and ammonium dihydrogen phosphate can significantly improve the hydrophilicity of the surface of the polypropylene intraocular lens delivery device material film. This means that the material surface is more likely to contact and wet with water, which helps to improve the lubrication effect. Improve the adhesion performance, and the thermal oxidation acid treatment can improve the adhesion performance of the surface of the polypropylene intraocular lens delivery device material film. This means that the material is more likely to adhere to and combine with other substances, which helps to improve the lubrication effect, and can effectively improve the bonding strength between the coating and the substrate, avoiding the coating from falling off when the intraocular lens is delivered.

Claims

1. A method for preparing an intraocular lens delivery device, characterized in that: The surface of the IOL delivery device has a lubricating coating; A method for preparing an intraocular lens delivery device is as follows: (1) subjecting the surface of the pretreated polypropylene intraocular lens delivery device material to low-temperature plasma treatment at a voltage of 70 V for 1.5 minutes to obtain a pretreated intraocular lens delivery device material; (2) preparing a 10 wt% 2-methacryloyloxyethyl phosphorylcholine / water solution; placing the pretreated intraocular lens delivery device material obtained in step (1) in the 2-methacryloyloxyethyl phosphorylcholine / water solution at a weight ratio of 1:5, evacuating and then passing nitrogen, cycling for 3 times, and then placing under electron beam irradiation for polymerization for 3 hours, with an irradiation dose of 10 kGy; (3) taking out the intraocular lens delivery device material obtained in step (2) and washing it with deionized water 5 times to obtain an intraocular lens delivery device with good lubrication effect; The preparation method of the pretreated polypropylene intraocular lens delivery device material is as follows: The polypropylene intraocular lens delivery device material is washed with acetone for 5 to 15 minutes, and then the polypropylene intraocular lens delivery device material is placed in a mixed solution at a weight ratio of 1:3 to 8 and subjected to a thermal oxidation treatment at 90 to 98° C. for 10 to 30 minutes. After the thermal oxidation treatment, the material is washed with cold water 3 to 7 times, and then washed with water at 50 to 70° C. until the pH value of the washing solution reaches neutral, and then dried until a constant weight is reached, thereby obtaining a pretreated polypropylene intraocular lens delivery device material. The mixed solution solvent is water, and contains 0.4 mol / L ammonium persulfate, 7 mol / L nitric acid, and 6.5 mol / L ammonium dihydrogen phosphate.

2. An intraocular lens delivery device, characterized in that: The method according to claim 1 is used for preparation.

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