Solubilizing composition for hydrophobic components in oral care and other water-based formulations

Abstract

The present disclosure provides a solubilizing composition comprising a first nonionic surfactant that is ethoxylated and a second nonionic surfactant that is an alkyl polyglycoside. At least 30wt% of the solubilizing composition is derived from one or more renewable sources. The solubilizing composition solubilizes and stabilizes one or more hydrophobic compounds. The first nonionic surfactant may be a fatty alcohol ethoxylate, such as ceteareth-25. The second nonionic surfactant may be decyl glucoside. The solubilizing composition may be used in personal care compositions such as mouthwashes to solubilize flavor compounds.

Description

SOLUBILIZING COMPOSITION FOR HYDROPHOBIC COMPONENTS IN ORAL CARE AND OTHER WATER-BASED FORMULATIONSTECHNICAL FIELD

[0001] The present disclosure relates to solubilizing compositions for hydrophobic compounds, and more particularly to a synergistic blend of nonionic surfactants for solubilization and stability of flavor compounds in oral care formulations.BACKGROUND

[0002] Hydrophobic compounds, whether of natural or synthetic origin, may be used in a variety of water-based formulations. These compounds can contribute to sensory and functional attributes, such as taste, aroma, and stability, which can enhance product performance and consumer satisfaction. However, the poor water solubility of hydrophobic compounds may present significant formulation challenges, particularly in aqueous systems. As such, effective solubilization and stabilization strategies may be required to incorporate these compounds uniformly into water-based formulations and maintain their consistent functionality.

[0003] Flavors, as an example of hydrophobic compounds, may be widely used in food, pharmaceutical, and personal care formulations to impart taste and olfactory characteristics. These flavors may improve user acceptance of products that might otherwise have an unpleasant or insufficient sensory profile. Such flavors could play a role in evoking sensations of freshness and hygiene, potentially making them integral to the success of various formulations.

[0004] In oral care formulations, such as mouthwashes, flavors may enhance hygiene and provide users with a heightened sense of cleanliness. The selection of a flavor for such applications may depend on criteria, including the absence of unpleasant sensations, the duration and rapid evolution of the flavor sensation, and the spontaneous identity of the flavor. These criteria are closely tied to the physicochemical properties of flavor molecules, which may include alcohols, aldehydes, esters, phenols, and hydrocarbons.

[0005] Many flavor molecules are hydrophobic, which may make their dispersion in aqueous formulations difficult. Vehicles such as humectants, hydrotropes, and other solubilizing aids may be used to facilitate the incorporation and stabilization of these molecules. While vehicles can assist in the incorporation of hydrophobic flavor molecules, they may temporarily alter flavor performance or impact the stability of the final product. As aresult, the selection of suitable vehicles must be approached carefully. Suitable vehicle(s) for oral care applications should be safe for oral use, compatible with other formulation ingredients, and capable of maintaining the stability and efficacy of the flavor compounds. Efficient solubilization may improve olfactory and taste perception and may ensure the uniform distribution of flavor compounds throughout the formulation.

[0006] Ethanol has traditionally been employed as a solubilizer for hydrophobic flavor compounds in oral care formulations. However, there is increasing consumer demand for alcohol-free alternatives, potentially due to concerns regarding oral irritation, religious restrictions, or regulatory considerations. This demand may drive the development of alternative solubilization systems that could effectively address these challenges while maintaining the efficacy and stability of hydrophobic flavor compounds.

[0007] The development of solubilization systems for hydrophobic compounds, including flavors, may provide opportunities to enhance product performance, align with sustainability goals, and meet evolving consumer expectations. These advancements may improve the incorporation of hydrophobic compounds into water-based formulations, expand formulation possibilities, and address challenges across diverse industries.

[0008] The challenges in developing effective solubilization systems for hydrophobic flavor compounds in oral care formulations include achieving sufficient solubilization capacity, maintaining long-term stability, ensuring compatibility with other formulation components, and meeting consumer expectations for product performance and sensory attributes. Additionally, there is a need for solubilization methods that are energy-efficient and environmentally friendly, aligning with broader sustainability goals in the personal care industry.

[0009] As the oral care market continues to evolve, there is an ongoing need for innovative approaches to address these challenges and improve the incorporation of hydrophobic flavor compounds in aqueous-based formulations. Such advancements have the potential to enhance product performance, expand formulation possibilities, and ultimately contribute to improved oral care experiences for consumers.SUMMARY

[0010] This summary is provided to introduce a selection of concepts in a simplified form that are further described below in the detailed description. This summary is not intended to identify key features or essential features of the claimed subject matter, nor is it intended to be used as an aid in determining the scope of the claimed subject matter.

[0011] According to an aspect of the present disclosure, a solubilizing composition is provided. The solubilizing composition includes a first nonionic surfactant, wherein the first nonionic surfactant is ethoxylated, and a second nonionic surfactant, wherein the second nonionic surfactant is an alkyl polyglycoside. At least 30wt% of the solubilizing composition is derived from one or more renewable sources and the solubilizing composition solubilizes and stabilizes one or more hydrophobic compounds.

[0012] According to other aspects of the present disclosure, the solubilizing composition may include one or more of the following features. The first nonionic surfactant may be a fatty alcohol ethoxylate. The first nonionic surfactant may be ceteareth-25. The alkyl polyglycoside may be decyl glucoside. The ratio of the first nonionic surfactant to the second nonionic surfactant may be between 0.2: 1 and 5: 1. The first nonionic surfactant may be a block copolymer of ethylene oxide and propylene oxide. At least 50wt% of the solubilizing composition may be derived from one or more renewable sources.

[0013] According to another aspect of the present disclosure, a composition for solubilizing a hydrophobic compound is provided. The composition includes one or more hydrophobic compounds and a solubilizing system. The solubilizing system includes a first nonionic surfactant, wherein the first nonionic surfactant is ethoxylated, and a second nonionic surfactant, wherein the second nonionic surfactant is an alkyl polyglycoside. At least 30wt% of the solubilizing system is derived from one or more renewable sources and the one or more hydrophobic compounds is solubilized and stabilized in the composition.

[0014] According to other aspects of the present disclosure, the composition for solubilizing a hydrophobic compound may include one or more of the following features. The hydrophobic compound may be a flavor compound. The hydrophobic compound may comprise at least one of menthol, methyl salicylate, peppermint oil, or eucalyptol. The first nonionic surfactant may be a fatty alcohol ethoxylate. The first nonionic surfactant may be ceteareth-25. The alkyl polyglycoside may be decyl glucoside. The ratio of the first nonionic surfactant to the second nonionic surfactant may be between 0.2: 1 and 5: 1.

[0015] According to another aspect of the present disclosure, a personal care composition is provided. The personal care composition includes a solubilizing system, one or more hydrophobic compounds, and water. The solubilizing system includes a first nonionic surfactant, wherein the first nonionic surfactant is ethoxylated, and a second nonionic surfactant, wherein the second nonionic surfactant is an alkyl polyglycoside. At least 30wt% of the solubilizing system is derived from one or more biorenewal sources and the one or more hydrophobic compounds is solubilized and stabilized in the composition.

[0016] According to other aspects of the present disclosure, the personal care composition may include one or more of the following features. The personal care composition may be a mouthwash. The hydrophobic compound may be a flavor compound. The first nonionic surfactant may be a fatty alcohol ethoxylate and the alkyl polyglycoside may be decyl glucoside. The first nonionic surfactant may be ceteareth-25. The personal care composition may further comprise at least one of cetylpyridinium chloride, sodium fluoride, or sodium saccharin.

[0017] The foregoing general description of the illustrative embodiments and the following detailed description thereof are merely exemplary aspects of the teachings of this disclosure and are not restrictive.BRIEF DESCRIPTION OF THE DRAWINGS

[0018] The disclosure can be understood in consideration of the following detailed description of various embodiments in connection with the accompanying drawings. Nonlimiting and non-exhaustive examples are described with reference to the following figures.

[0019] FIG. 1 illustrates a bar graph comparing initial and final foam volumes for different formulations, according to aspects of the present disclosure.

[0020] FIG. 2 depicts a bar graph comparing initial and final foam sizes for different formulations, according to an embodiment.DETAILED DESCRIPTION

[0021] For purposes of promoting an understanding of the principles of the disclosure, reference will now be made to the embodiments illustrated in the drawings, and specific language will be used to describe the same. It will nonetheless be understood that no limitation of the scope of the disclosure is intended by the illustration and description of certain embodiments of the disclosure. In addition, any alterations and / or modifications of the illustrated and / or described embodiment(s) are contemplated as being within the scope of the present disclosure. Further, any other applications of the principles of the disclosure, as illustrated and / or described herein, as would normally occur to one skilled in the art to which the disclosure pertains, are contemplated as being within the scope of the present disclosure.

[0022] The following description sets forth exemplary aspects of the present disclosure. It should be recognized, however, that such description is not intended as a limitation on the scope of the present disclosure. Rather, the description also encompasses combinations and modifications to those exemplary aspects described herein.

[0023] As used herein, the term “renewable source” refers to any resource that is naturally replenished or regenerated on a human timescale. Renewable sources may include biological materials derived from plants, algae, microorganisms, and their derivatives, as well as non- biological resources such as solar energy, wind energy, and hydropower. Renewable sources are distinct from nonrenewable resources, such as fossil fuels, which are finite and take millions of years to regenerate.

[0024] As used herein, the term “biorenewable source” refers to any renewable resource derived from biological processes, including plants, algae, microorganisms, and their derivatives. These materials are replenishable on a human timescale and are distinct from nonrenewable, petrochemical-based resources. Biorenewable sources may include plant-based fatty alcohols, sugars, cellulose, starches, and natural oils, which can serve as feedstocks for producing nonionic surfactants and other components.

[0025] As used herein, the term “biodegradability” refers to the ability of a substance to be broken down into smaller compounds, such as carbon dioxide, water, and biomass, through the action of microorganisms, enzymes, or other biological processes. Biodegradability may be assessed under standardized conditions, such as those specified in OECD Test Guidelines 301, and a material may be considered biodegradable if it achieves at least 60% mineralization within 28 days under aerobic conditions.

[0026] As used herein, the term “biocompatibility” refers to the ability of a material or substance to interact with biological systems without eliciting significant adverse effects, such as toxicity, irritation, or an immune response. Biocompatibility may be evaluated using in vitro or in vivo assays, including cytotoxicity testing, irritation studies, and allergenicity assessments, to confirm its suitability for use in personal care or medical applications.

[0027] As used herein, the term “bioavailability” refers to the extent to which a compound, such as a flavor or active ingredient, becomes available at its site of action or absorption in the intended biological system. Bioavailability may depend on factors such as solubility, stability, and the formulation matrix, and it may be assessed through pharmacokinetic studies or sensory evaluations, depending on the application.

[0028] As used herein, the term “nonionic surfactant” refers to a surfactant that does not possess a net electric charge in its hydrophilic head group. Nonionic surfactants derive their solubility in water from the presence of polar functional groups, such as ethylene oxide chains, rather than an ionic charge. These surfactants are generally mild and compatible with a wide range of ingredients, making them suitable for various formulations, including personal care and pharmaceutical applications.

[0029] As used herein, the term “anionic surfactant” refers to a surfactant that carries a negative electric charge in its hydrophilic head group when dissolved in water. Examples of anionic surfactants include those containing sulfate, sulfonate, phosphate, or carboxylate groups. Anionic surfactants are commonly used for their excellent cleaning, foaming, and emulsifying properties.

[0030] As used herein, the term “cationic surfactant” refers to a surfactant that carries a positive electric charge in its hydrophilic head group when dissolved in water. Cationic surfactants, such as quaternary ammonium compounds, are typically used for their antimicrobial, conditioning, and softening properties.

[0031] As used herein, the term “effective” or “effectively” refers to a property, function, or performance characteristic that is maintained, enhanced, or not diminished to an extent that would adversely impact the overall functionality, stability, or intended performance of the composition, system, or method.

[0032] Sensory compounds or sensory-active compounds, including flavors, aromas, and fragrances, may play a role in enhancing the sensory perception of food, pharmaceutical, and personal care formulations. These compounds, whether natural or synthetic, contribute to taste, smell, and overall product appeal. Sensory-active compounds may be volatile and hydrophobic, making their incorporation into water-based formulations challenging. To overcome these challenges, solubilization strategies must ensure consistent dispersion, stability, and performance to meet consumer expectations and enhance product acceptance.

[0033] Surfactants may serve as promising candidates for solubilizing hydrophobic compounds in aqueous environments. These amphiphilic molecules can reduce interfacial tension and promote the formation of micelles, which can encapsulate hydrophobic substances. Surfactants may promote homogeneous dispersion, mask odor and taste, and enhance foam formation, improving the sensory experience of products, such as oral care products. The selected surfactant(s) for oral care applications should be safe for oral use, compatible with other formulation ingredients, and capable of maintaining the stability and efficacy of the flavor compounds.

[0034] The choice of surfactants depends on their physicochemical properties, including chemical nature, molecular weight, hydrophilic-lipophilic balance (HLB), compatibility with other formulation ingredients, and critical micelle concentration (CMC). These properties can aid in forming stable oil-in-water micellar systems that facilitate solubilization. Efficient solubilization of flavor compounds can improve their olfactory and taste perception but depends on factors such as the hydrophobicity (Log P) and conformational organization of theactive ingredient. For instance, active ingredients with a Log P greater than 2 exhibit significant hydrophobicity, while those with a Log P above 10 often have high lipophilicity and complex sizes and structures, making their dispersion particularly challenging.

[0035] HLB (Hydrophilic-Lipophilic Balance) is a numerical scale (ranging from 0 to 20) used to describe the balance between the hydrophilic (water-loving) and lipophilic (oil-loving) portions of a surfactant molecule. The HLB value can help predict the surfactant's solubility and its suitability for specific applications, such as emulsification or solubilization. Low HLB values of 0-8 may indicate a lipophilic surfactant, suitable for stabilizing water-in-oil (W / O) emulsions. High HLB values of 12-20 may indicate a hydrophilic surfactant, suitable for stabilizing oil-in-water (O / W) emulsions or solubilizing hydrophobic compounds in water.

[0036] The conformational organization of hydrophobic compounds may influence their efficient solubilization in a formulation, particularly through their incorporation into micelles or similar structures. Micelles, which may form when the concentration of surfactants exceeds the critical micelle concentration (CMC), are characterized by a core of hydrophobic surfactant tails surrounded by hydrophilic surfactant heads. This arrangement may allow micelles to encapsulate hydrophobic compounds within their core, thereby facilitating solubilization and dispersion in aqueous formulations.

[0037] Hydrophobic compounds with compact or symmetrical molecular structures may more easily interact with the hydrophobic regions of surfactants, which may promote their incorporation into micelles. Conversely, hydrophobic compounds with larger, irregular, or highly branched conformations may experience steric hindrance, which may reduce their ability to integrate into micelles and, consequently, may affect solubilization efficiency. The compatibility between the hydrophobic and hydrophilic regions of the solubilizing agents and the hydrophobic compound may influence the stability and efficiency of micelle formation, which may contribute to improved solubilization within the formulation.

[0038] Technological strategies to overcome these barriers include the use of surfactant blends with different HLB values. In such systems, a hydrophobic surfactant can effectively interact with the solubilized active ingredient, while a hydrophilic surfactant enhances colloidal stability. Various surfactant blends may be employed, ranging from ethoxylated surfactants that reduce interfacial tension to surfactants derived from biorenewable sources, contributing to sustainability.

[0039] This disclosure highlights the use of blends of nonionic surfactants derived from renewable or biorenewable sources, such as alkyl polyglycosides and decyl polyglycosides, combined with fatty alcohols of varying levels of ethoxylation (e.g., ceteareth-25) and / or blockcopolymers (e.g., pol oxamer 407). One or more of the surfactants may be 100% plant-based and renewable. The chemical properties of the compositions may be varied by, for example, selecting the level of ethoxylation of the fatty alcohol or addition, reduction, or elimination of block copolymers (e.g., poloxamer 407). In some examples, the surfactant blend to solubilize the sensory compound (e.g., flavor, aroma) may be used to reduce or eliminate the amount of block copolymer (e.g., poloxamer 407) in the surfactant blend, which may reduce costs, increase in vegetalization index, and provide a more sustainable option since one or more of the surfactants may be renewable. Additionally, the disclosed formulations utilize a low-shear energy method and direct addition of flavor compounds. This approach reduces the carbon footprint by eliminating the need for organic solvents during solubilization while maintaining or improving the stability and efficacy of the active ingredients.

[0040] Nonionic surfactant may be suitable in oral care formulations due to their generally mild nature and compatibility with a wide range of ingredients. As sustainability becomes an increasingly important consideration in product development, nonionic surfactants can be derived from renewable or biorenewable sources.

[0041] The present disclosure relates to solubilizing compositions. In some cases, the solubilizing compositions may comprise a combination of nonionic surfactants that work synergistically to solubilize and stabilize hydrophobic compounds, such as flavor compounds, in aqueous formulations.

[0042] The solubilizing compositions may include a first nonionic surfactant that is ethoxylated and a second nonionic surfactant that is an alkyl polyglycoside. The combination of surfactants may maintain or provide improved solubilization and stabilization of hydrophobic compounds compared to conventional solubilizers, such as those derived from sources that are not renewable (e.g., biorenewable). In some cases, at least 30wt% of the solubilizing composition may be derived from one or more renewable or biorenewable sources, providing an environmentally friendly alternative to fully synthetic solubilizers.

[0043] The solubilizing compositions may be incorporated into personal care compositions, such as mouthwash formulations. These personal care compositions may comprise a solubilizing system, one or more hydrophobic compounds, and water. The hydrophobic compounds may include flavor compounds, which are commonly used in mouthwash formulations to provide a pleasant taste and sensory experience.

[0044] In some cases, the solubilizing compositions may be used to create a composition for solubilizing hydrophobic compounds. Such compositions may comprise one or more hydrophobic compounds and the solubilizing system. The solubilizing system may effectivelydisperse and stabilize the hydrophobic compounds in the aqueous environment of the personal care product.

[0045] The solubilizing compositions disclosed herein may offer several advantages over conventional solubilizers, such as maintaining or improving solubilization efficiency, maintaining or enhancing stability of hydrophobic compounds, and the use of more environmentally friendly ingredients. Additionally, the solubilizing compositions may be particularly well-suited for use in mouthwash formulations, where effective solubilization of flavor compounds may contribute to product performance and consumer acceptance.

[0046] The solubilizing composition may comprise a first nonionic surfactant that is ethoxylated. In some cases, the first nonionic surfactant may be a fatty alcohol ethoxylate. Fatty alcohol ethoxylates are nonionic surfactants produced by the ethoxylation of fatty alcohols. The ethoxylation process involves the addition of ethylene oxide units to the fatty alcohol molecule, resulting in a compound with both hydrophobic and hydrophilic properties.

[0047] In some cases, the fatty alcohol ethoxylate may be ceteareth-25. Ceteareth-25 may be derived from cetyl and stearyl alcohols (fatty alcohols) that are ethoxylated (reacted with ethylene oxide). Ceteareth-25 may be produced by the ethoxylation of cetearyl alcohol with an average of 25 moles of ethylene oxide per mole of alcohol. The “25” in the name indicates the average number of ethylene oxide (EO) units per molecule.

[0048] Ceteareth-25 may have the structure:R-O-(CH2CH2O)n-H where R is the fatty alcohol chain (typically 16-18 carbon atoms, from cetyl and stearyl alcohols) and n is the average number of ethylene oxide units (25 in this case).

[0049] Fatty alcohol ethoxylates, such as ceteareth-25, may function as emulsifiers and solubilizers, helping to disperse and stabilize hydrophobic compounds in aqueous solutions. Ceteareth-25 has an approximate HLV value of 16, which is considered relatively high. The hydrophobic fatty alcohol portion of the molecule may interact with hydrophobic compounds, such as flavor compounds, while the hydrophilic ethylene oxide chain may help maintain solubility in water.

[0050] Fatty alcohol ethoxylates can effectively contribute to the performance of the solubilizing system. The fatty alcohol ethoxylate may help solubilize hydrophobic compounds, such as flavor compounds, by forming micelles or other structures that encapsulate the hydrophobic molecules. The presence of fatty alcohol ethoxylates in the solubilizing system may enhance the stability of the solubilized hydrophobic compounds, preventing precipitation or separation over time. Fatty alcohol ethoxylates may reduce the interfacial tension betweenthe aqueous phase and the hydrophobic compounds, facilitating their dispersion and solubilization. When combined with other nonionic surfactants, such as alkyl polyglycosides, fatty alcohol ethoxylates may exhibit synergistic effects, potentially enhancing the overall solubilization capacity and stability of the system.

[0051] The use of fatty alcohol ethoxylates, such as ceteareth-25, in the solubilizing system may offer several advantages. Fatty alcohol ethoxylates may be effective solubilizers at relatively low concentrations, potentially allowing for more economical formulations. These compounds may be generally mild and well-tolerated in personal care applications, such as mouthwash formulations. Fatty alcohol ethoxylates may be compatible with a wide range of ingredients commonly used in personal care products, allowing for flexibility in formulation. In some cases, fatty alcohol ethoxylates may contribute to improved foam characteristics in the final product, which may be desirable in certain applications.

[0052] The specific choice of fatty alcohol ethoxylate and its concentration in the solubilizing system may depend on various factors, including the nature of the hydrophobic compounds to be solubilized, the desired performance characteristics of the final product, and compatibility with other ingredients in the formulation.

[0053] The solubilizing composition may comprise a second nonionic surfactant. In some examples, the second nonionic surfactant is an alkyl polyglycoside (APG). Alkyl polyglycoside may be derived from fatty alcohols (alkyl chains) and sugars (e.g., glucose). APG are characterized by having one or more sugar (glycoside) units attached to an alkyl chain. The alkyl chain length and the number of sugar units can vary, leading to a range of surfactants with different properties. In some cases, the alkyl polyglycoside may be derived from one or more renewable resources. The alkyl polyglycoside may be produced by the reaction of glucose from corn starch with fatty alcohols from coconut or palm kernel oil. Alkyl polyglycosides may have a hydrophilic sugar group (the glycoside) and a hydrophobic alkyl chain, giving them amphiphilic properties. APG may have an approximate HLB range of 10- 14, which may mean APG is suitable for oil-in-water (O / W) emulsions and solubilization of hydrophobic compounds in aqueous formulations.

[0054] In some cases, the alkyl polyglycoside may be decyl glucoside. Decyl glucoside is a specific type of alkyl polyglycoside where the alkyl group is a 10-carbon chain (decyl) attached to one or more glucose units (e.g., one or small number of units). Decyl glucoside may be derived from coconut oil or palm kernel oil (for the alkyl chain) and glucose (from corn or other plant sources). The structure of decyl glucoside may provide a balance between hydrophilicity and lipophilicity, which may make it an effective surfactant and solubilizer.Decyl glucoside may have an approximate HLB range of 11-13, making it suitable for O / W emulsions and solubilization of hydrophobic compounds in aqueous formulations.

[0055] Alkyl polyglycosides, such as decyl glucoside, can effectively contribute to the performance of the solubilizing system. The amphiphilic nature of alkyl polyglycosides may allow them to interact with both hydrophobic compounds and water, facilitating the solubilization of flavor compounds in aqueous solutions. Alkyl polyglycosides may act as emulsifiers, helping to stabilize dispersions of hydrophobic compounds in water. In some cases, alkyl polyglycosides may contribute to improved foam characteristics in the final product, which may be desirable in certain applications such as mouthwash. When combined with other nonionic surfactants, such as fatty alcohol ethoxylates (e.g., ceteareth-25), alkyl polyglycosides may exhibit synergistic effects, potentially enhancing the overall solubilization capacity and stability of the system.

[0056] Alkyl polyglycosides can be considered mild and well-tolerated, which may be advantageous in personal care applications, such as oral care products. Nonionic surfactants, such as alkyl polyglycosides, may have a lower skin and mucosal irritation potential than other surfactants, such as anionic surfactants. Alkyl polyglycosides may not strip the skin of natural lipids as other surfactants. Alkyl polyglycosides derived from natural, plant-based sources (e.g., fatty alcohols and sugars) may exhibit biocompatibility, such as reduce the risk of allergic reactions or toxicity.

[0057] The use of alkyl polyglycosides, particularly decyl glucoside, in the solubilizing system may offer several advantages. Alkyl polyglycosides may be readily biodegradable, which may be beneficial for environmental considerations. Alkyl polyglycosides may not accumulate in the environment, which may help reduce indirect harm from product residues. These compounds can be derived from renewable or biorenewable resources, aligning with sustainability goals. Alkyl polyglycosides may be compatible with a wide range of ingredients commonly used in personal care products, allowing for flexibility in formulation. The mild nature of alkyl polyglycosides may make them suitable for use in sensitive applications such as oral care products.

[0058] The specific choice of alkyl polyglycoside and its concentration in the solubilizing system may depend on various factors, including the nature of the hydrophobic compounds to be solubilized, the desired performance characteristics of the final product, and compatibility with other ingredients in the formulation.

[0059] The solubilizing compositions disclosed herein may be particularly useful for solubilizing flavor compounds in personal care products, such as mouthwash formulations.Flavor compounds may be hydrophobic in nature, which can present challenges when incorporating them into aqueous formulations.

[0060] In some cases, the flavor compounds used in the invention may include menthol, methyl salicylate, peppermint oil, and eucalyptol. These compounds may be used in oral care products to provide a pleasant taste and sensory experience. However, their hydrophobic nature can make them difficult to solubilize and stabilize in aqueous formulations.

[0061] Menthol, for example, is a cyclic terpene alcohol that provides a cooling sensation and minty flavor. Methyl salicylate, also known as wintergreen oil, imparts a characteristic wintergreen flavor. Peppermint oil is a complex mixture of various compounds, including menthol, menthone, and menthyl acetate, which contribute to its refreshing minty flavor. Eucalyptol, also known as 1,8-cineole, is a cyclic ether that provides a fresh, camphoraceous aroma and taste.

[0062] The hydrophobic nature of these flavor compounds may present several challenges in formulating personal care products. These compounds can exhibit limited solubility in water, which can result in poor dispersion and potential separation within aqueous formulations. Even when initially solubilized, hydrophobic flavor compounds may exhibit stability problems with a tendency to separate or precipitate over time, leading to inconsistent flavor delivery and a reduced product shelf life. Poor solubilization of these compounds may decrease their bioavailability, potentially diminishing their sensory impact and effectiveness. Traditional methods of solubilizing hydrophobic compounds may be complex, often requiring high levels of surfactants or cosolvents, which may negatively affect other aspects of the formulation, such as mildness, compatibility, or overall performance.

[0063] The solubilizing compositions of the present invention may address these challenges through the synergistic combination of nonionic surfactants. The combination of an ethoxylated nonionic surfactant and an alkyl polyglycoside may create a solubilizing system that effectively encapsulates and disperses hydrophobic flavor compounds in aqueous formulations.

[0064] In some cases, the ethoxylated nonionic surfactant may interact with the hydrophobic portions of the flavor compounds, while the alkyl polyglycoside may help to stabilize the resulting structures in the aqueous environment. This synergistic interaction may result in improved solubilization efficiency, enhanced stability, and potentially increased bioavailability of the flavor compounds.

[0065] The solubilizing compositions may be particularly effective for solubilizing complex mixtures of flavor compounds, such as those found in essential oils like peppermintoil. The diverse chemical structures present in these natural extracts can often present additional challenges in solubilization, which may be overcome by the versatile nature of the disclosed solubilizing system.

[0066] Furthermore, the use of mild, biocompatible surfactants in the solubilizing compositions may allow for effective flavor compound solubilization without the need for high levels of harsh surfactants or cosolvents. This may result in formulations that are gentler on oral tissues while still delivering the desired sensory experience.

[0067] In some cases, the improved solubilization and stabilization of flavor compounds achieved by the disclosed compositions may lead to several benefits in personal care products. These compositions may enhance flavor intensity and longevity, delivering a more pronounced and lasting sensory experience. They may improve product stability and shelf life by maintaining the uniform dispersion of flavor compounds over time. The enhanced solubilization may allow for a reduction in the amount of flavor compounds required while still maintaining the desired sensory impact, potentially leading to more cost-effective formulations. The disclosed compositions may offer greater formulation flexibility and compatibility with other ingredients, enabling the development of more versatile and innovative personal care products.

[0068] By effectively addressing the challenges associated with solubilizing hydrophobic flavor compounds, the compositions of the present invention may enable the development of improved personal care products, particularly in the realm of oral care formulations such as mouthwashes.

[0069] The solubilizing compositions disclosed herein may exhibit synergistic interactions between the fatty alcohol ethoxylate and alkyl polyglycoside components, leading to enhanced flavor solubilization and stability. This synergistic effect may result in improved performance compared to the use of individual components alone.

[0070] In some cases, the ratio of the first nonionic surfactant (fatty alcohol ethoxylate) to the second nonionic surfactant (alkyl polyglycoside) may be between 0.2: 1 and 5: 1. This range of ratios may provide optimal synergistic effects for solubilizing and stabilizing hydrophobic compounds, such as flavor compounds, in aqueous formulations. In some examples, ceteareth- 25 may be 0.2-1% by weight of the total composition and decyl glucoside may be 0.2-1% by weight of the total composition.

[0071] The combination of fatty alcohol ethoxylate and alkyl polyglycoside may create a more effective solubilizing system through complementary mechanisms. The fatty alcohol ethoxylate may interact primarily with the hydrophobic portions of flavor compounds, whilethe alkyl polyglycoside may help stabilize the resulting structures in the aqueous environment. This synergistic interaction may lead to improved solubilization efficiency and enhanced stability of the solubilized hydrophobic compounds.

[0072] In some cases, at least 30wt% of the solubilizing system may be derived from one or more biorenewal sources. The use of alkyl polyglycosides, which can be derived from renewable resources, may contribute significantly to this aspect. In some cases, at least 50wt% of the solubilizing composition may be derived from one or more biorenewal sources, further enhancing the sustainability profile of the composition.

[0073] The solubilizing composition may further comprise a block copolymer of ethylene oxide and propylene oxide (EO / PO). In some cases, this copolymer may be poloxamer 407, a specific EO / PO copolymer surfactant. Poloxamer 407 is a synthetic, non-ionic triblock copolymer composed of a central hydrophobic block of polypropylene oxide (PPO) flanked by two hydrophilic blocks of polyethylene oxide (PEO). Its chemical structure can be represented as: PEO-PPO-PEO. The addition of an EO / PO copolymer to the solubilizing system may further enhance the solubilization and stabilization of hydrophobic compounds. Poloxamer 407 may have an approximate HLV range of 18-23, suggesting strong hydrophilic nature.

[0074] The synergistic interaction between the fatty alcohol ethoxylate, alkyl polyglycoside, and optional EO / PO copolymer may result in a solubilizing system that effectively solubilizes and stabilizes one or more hydrophobic compounds in the composition. The enhanced solubilization and stabilization may lead to improved performance in personal care products, such as mouthwash formulations. The combination of these components may offer several advantages. The synergistic interaction may allow for more effective solubilization of hydrophobic compounds at lower total surfactant concentrations or improved solubilization efficiency. The complementary mechanisms of the different surfactants may result in more stable solubilized structures, potentially improving the shelf life of the final product. The ability to adjust the ratio of components may allow for fine-tuning of the solubilizing system to accommodate different types of hydrophobic compounds or formulation requirements. The use of renewable-sourced or biorenewable-sourced components, such as alkyl polyglycosides, may contribute to a more environmentally friendly product profile. The synergistic effects may allow for effective solubilization at lower total surfactant concentrations, potentially reducing the risk of irritation in sensitive applications such as oral care products.

[0075] In some cases, the personal care composition may further comprise at least one of cetylpyridinium chloride, sodium fluoride, or sodium saccharin. These additional componentsmay contribute to the overall performance and efficacy of the formulation. For example, cetylpyridinium chloride may provide antimicrobial properties, sodium fluoride may offer anticaries benefits, and sodium saccharin may enhance the taste profile of the formulation.

[0076] In some cases, the synergistic interactions between the components of the solubilizing system may result in unexpected improvements in performance compared to what may be predicted based on the properties of the individual components. This synergistic effect may be particularly beneficial in challenging applications, such as the solubilization of complex flavor compounds in mouthwash formulations.

[0077] In some cases, the preparation method may involve the following steps:

[0078] 1. Preparing a premix: A premix containing oral care active ingredients may be prepared. The premix may include active ingredients and humectants. Active ingredients may include 1 -hexadecylpyridinium chloride (cetylpyridinium chloride, CPC) and sodium fluoride. CPC may be used as an antimicrobial active ingredient. Sodium fluoride may be used as an anticaries active ingredient. Humectants may be associated with antimicrobial and anticaries agents. Examples of humectants include glycerin, sodium saccharin, sorbitol, and polypropylene glycol. In some cases, the premix may include cetylpyridinium chloride, potassium sorbate, sodium fluoride, sodium saccharin, citric acid, propylene glycol, and glycerin. In some cases, the premix may include sorbitol. In some cases, the premix may include propylene glycol, polypropylene glycol, or both. In some cases, the propylene glycol may be replaced by polypropylene glycol. In some cases, the premix may include cetylpyridinium chloride, sodium fluoride, sodium saccharin, polypropylene glycol, glycerin, and sorbitol. The premix may comprise 18-22% by weight of the total composition. The ingredients of the premix may be combined and stirred until complete solubilization is achieved.

[0079] 2. Adding the solubilizing system or surfactant(s): The surfactant(s) may be added to the premix. The surfactants may be a flavor solubilizer and a foam booster. One or more of the surfactant(s) may be nonionic surfactants. The surfactant(s) should be compatible with an active ingredient, such as CPC. The surfactants may include one or more of a fatty alcohol ethoxylate, a block copolymer, and an alkyl polyglycoside. The surfactants may be 0.05-3%, 0.1-2.5%, 0.2-2%, 0.5-2%, 0.2-1%, or any percentage therebetween by weight of the total composition. The mixture may be stirred to achieve a homogeneous blend.

[0080] 3. Adding flavor compounds: The flavor compounds may be added directly to the surfactant-premix mixture. The surfactants may be 0.05-1%, 0.15-0.25% or any percentagetherebetween by weight of the total composition. This direct addition of flavor compounds may be possible due to the efficient solubilizing properties of the surfactant blend.

[0081] 4. Preparing the aqueous phase: In a separate vessel, deionized water may be prepared and placed under magnetic agitation.

[0082] 5. Combining phases: The surfactant-premix-flavor mixture may be slowly poured into the agitated water. The addition may be performed while maintaining constant agitation to ensure proper dispersion and solubilization.

[0083] 6. Final mixing: The combined formulation may be kept under agitation for approximately 20 minutes to ensure complete mixing and solubilization of all components.

[0084] 7. Resting period: After mixing, the formulation may be allowed to rest for 24 hours before evaluating its appearance and foam behavior.

[0085] The solubilizing compositions disclosed herein may be prepared using a low shear energy method (e.g., low-shear mixing), which allows for direct addition of flavor compounds to other components (e.g., pre-mix, surfactants). The low-shear method may be used to mix the individual components of the pre-mix, solubilizing system, or flavor(s). Additionally, the low- shear method may facilitate the combination of the pre-mix, solubilizing system, flavor, and water, ensuring distribution and incorporation through the composition.

[0086] The low shear energy method (e.g., low-shear mixing) is a manufacturing process that incorporates flavors into a composition while minimizing mechanical shear. The base components (e.g., pre-mix, surfactants) may be mixed using low-shear mixing by using low- speed agitators or other mixing equipment (e.g., paddle mixers, magnetic stirrers) to minimize shear forces. Low-shear mixing can ensure a uniform base composition (e.g., pre-mix) without over-aeration or emulsification that could destabilize the flavor. After the pre-mix has been homogenized or stabilized, the flavor compound can be added directly to the pre-mix. The flavor compound may be added while the pre-mix is still be stirred. Low-shear equipment may create a vortex or controlled turbulence to dispense the flavor evenly without excessive shear. High-shear homogenizers, ultrasonic emulsifiers, or rapid mixing equipment can break down sensitive flavor compounds and cause over-dispersion, aeration, or destabilization of the composition. The low-shear energy method may be used to preserve the integrity, stability, and sensor characteristics of the flavor compounds, which may be volatile or sensitive to high shear or heat. The low shear energy method may contribute to reducing the carbon footprint of the formulation by eliminating the need for organic solvents in the solubilization of active ingredients.

[0087] The low shear energy method employed in this preparation process may provide several advantages, including reduced energy consumption, the ability to add flavors directly, and simplified, gentle processing. The use of low shear mixing may require less energy compared to high-shear methods, potentially reducing the overall energy footprint of the production process. The ability to add flavor compounds directly to the formulation may eliminate the need for pre-solubilization steps or the use of organic solvents, further reducing the environmental impact of the production process. The straightforward mixing procedure may reduce the complexity of the manufacturing process, potentially leading to increased efficiency and reduced resource consumption. The low shear method may be less likely to cause degradation of sensitive ingredients, potentially improving the overall quality and stability of the final product.

[0088] In some cases, the low shear energy method may involve magnetic stirring at room temperature. This gentle mixing approach may be sufficient to achieve proper solubilization and dispersion of the flavor compounds due to the efficient solubilizing properties of the surfactant blend.

[0089] The preparation method described herein may result in a clear, homogeneous formulation with effectively solubilized flavor compounds. The method may be particularly well-suited for preparing mouthwash formulations, where efficient flavor solubilization and stability are crucial for product performance and consumer acceptance.

[0090] The performance characteristics of the flavor solubilizer composition may be evaluated to assess its effectiveness in personal care formulations, particularly in mouthwash applications. In some cases, the composition may demonstrate improved foam volume, stability, and creaminess compared to traditional formulations.

[0091] Foam volume and creaminess may be evaluated using a Kruss DFA 100 foam analyzer. This instrument allows for precise measurement of foam characteristics, providing quantitative data on the performance of different formulations.

[0092] EXAMPLE

[0093] Different compositions of mouthwash were prepared and subjected to visual evaluation and foam characterization. As shown in TABLE 1, compositions Fl, F2, F3, and F4 included the following components: pre-mix, surfactant(s), flavor(s), and deionized water. The pre-mix included cetylpyridinium chloride, potassium sorbate, sodium fluoride, sodium saccharin, citric acid, propylene glycol, glycerin, and water and was present at 18-22% by weight of the composition. The surfactant(s) (e.g. solubilizing system) were present at 0.2-2% by weight of the composition. The flavor(s) were present at 0.15-0.25% by weight of thecomposition. The deionized water was Q.S.P. (quantity sufficient to prepare the composition), bringing the total to 100% by weight.TABLE 1

[0094] Steps and addition order: (1) The premix ingredients were weighed in a vessel (A) and stirred for complete solubilization. (2) The surfactants were added to the premix ingredients in vessel (A) while maintaining stirring agitation to achieve a homogeneous mixture. (3) The flavor(s) were added to premix ingredients and surfactants in vessel (A). (4) Water was weighed in a different vessel (B) and magnetically agitated or stirred. (5) The contents (e.g., premix, surfactants, flavor(s)) of vessel (A) were slowly poured over the water in vessel (B) while maintaining agitation during transfer time. (6) The contents of vessel (B) was agitated for 20 minutes. (7) Agitation was discontinued, and the mixture of vessel (B) was allowed to rest for 24 hours before evaluation of appearance and foam behavior were made.

[0095] Visual appearance and behavior were evaluated for each composition. The foam profile of each undiluted composition was determined using a Kruss DFA 100 foam analyzer. The foam profile included foam volume and foam creaminess.

[0096] Appearance Observations:

[0097] The F3 composition containing only decyl glucoside without any other surfactant, did not exhibit good performance. The F3 composition was not clear. Small drops of insoluble flavor compounds were observed on the surface of the liquid, indicated instability. Due to this instability, the composition was not evaluated using a foam analyzer.

[0098] Compositions Fl (Pol oxamer 407), F2 (Ceteareth-25), and F4 (a combination of Ceteareth-25 and Decyl Glucoside) resulted in a final mixture with a very good appearance. All formulations were completely clear and homogeneous.

[0099] Foam results:

[0100] FIG. 1 illustrates the foam volume characteristics of various compositions. The graph compares the initial foam volume and final foam volume across three different compositions. As shown in FIG. 1, the composition containing a combination of fatty alcohol ethoxylate and alkyl polyglycoside (F4) demonstrates significantly higher initial and final foam volumes compared to formulations containing only a single surfactant (Fl and F2). This increased foam volume may contribute to an enhanced sensory experience for users of the personal care product.

[0101] FIG. 2 presents data on foam size, which may be indicative of foam creaminess. The graph compares initial and final foam sizes for the same three compositions. As illustrated in FIG. 2, the composition containing the combination of fatty alcohol ethoxylate and alkyl polyglycoside (F4) exhibits a smaller final foam size compared to the other compositions. This smaller foam size may translate to a creamier foam texture, potentially improving the overall sensory experience of the product.

[0102] Compositions developed with Ceteareth-25 (F2) and Poloxamer 407 (Fl) exhibited very similar foam profiles with no significant differences observed between them. Composition F4 combining Ceteareth-25 with Decyl Glucoside demonstrated an excellent foam profile, characterized by higher foam volume and creaminess (smaller bubble size) compared to formulations containing only a single surfactant.

[0103] The chemical stability and solubilization properties of the disclosed formulation may be enhanced compared to previous formulations. For example, formulations that include surfactant blends, such as fatty alcohol ethoxylates and alkylpolyglycosides, may provide improved clarity, foam volume, and creaminess compared to formulations containing single surfactants.

[0104] Composition F4 was measured against compositions Fl, F2, and F3. The data suggests that blends, such as fatty alcohol ethoxylates and alkylpolyglycosides, significantly improved clarity, foam volume, and creaminess, addressing issues of flavor insolubility and instability seen in F3. The clear, homogenous nature of Fl, F2, and F4 formulations demonstrates enhanced solubilization compared to the instability and flavor separation in F3.

[0105] The enhancement of chemical stability and solubilization of the disclosed formulation compared to previous formulations may be defined through specific metrics, including:

[0106] Foam Behavior: Higher volume and smaller bubble size (creaminess) were achieved in F4 due to synergistic interactions of surfactants.

[0107] Visual Clarity: F4 had improved solubilization. The final composition of F4 was homogenous and clear with no insoluble flavor droplets on the surface.

[0108] Efficiency: Lower surfactant concentration in blends yielded comparable or superior results compared to fully synthetic surfactants.

[0109] Key Parameters:

[0110] The hydrophilic-lipophilic balance (HLB) of the chosen surfactants in blends optimized their interaction with both hydrophobic and hydrophilic phases.[oni] The low-shear energy method maintained the structural integrity of the actives and flavors, further stabilizing the final product.

[0112] Theoretical Postulation for Enhancement:

[0113] Without being bound by theory, the enhancement in stability and solubilization properties may result from the synergistic interaction between the components of the solubilizing system:

[0114] Sy nergi sm of Surfactants :

[0115] The interaction between fatty alcohol ethoxylates and alkylpolyglycosides creates a dual-role system. The combination of fatty alcohol ethoxylates and alkylpolyglycosides may form micelles or similar structures, where the hydrophobic surfactants interact or aligns with the nonpolar regions of the flavor molecules, while the hydrophilic surfactants stabilize these interactions in an aqueous environment.

[0116] This synergy may reduce interfacial tension, promote micelle formation, and ensure homogenous dispersion, improving the incorporation and stability of hydrophobic compounds in the aqueous formulation.

[0117] Micelle Formation and Stability:

[0118] The solubilizing system may promote the formation of micelles or other structures capable of encapsulating hydrophobic flavor molecules. The compatibility of the hydrophobic and hydrophilic regions of the surfactants and the flavor compounds may contribute to the efficient and stable incorporation of these molecules. Efficient solubilization depends on the formation of stable micelles capable of encapsulating hydrophobic flavor molecules. Compact or symmetrical molecular structures are better integrated into these micelles, while irregular molecules might require higher surfactant concentrations or blends.

[0119] Foam Characteristics:

[0120] The synergistic interaction of surfactants may enhance foam characteristics, including volume and bubble size, which may improve sensory perception. These benefits may be particularly advantageous in applications such as oral care products. Smaller bubble sizesand higher foam volume in F4 formulations suggest that surfactant blends influence interfacial dynamics, promoting foam stability and consumer sensory experience.

[0121] Low- Shear Energy Method:

[0122] The disclosed low-shear energy method may preserve the structural integrity of the actives and flavors, thereby reducing the potential for degradation and improving the overall stability and efficacy of the formulation. Additionally, this method may reduce the carbon footprint by eliminating the need for organic solvents during solubilization.

[0123] These enhancements may collectively contribute to a formulation with improved performance, stability, and sensory attributes, addressing challenges commonly associated with the solubilization of hydrophobic compounds.

[0124] The combination of improved foam characteristics and the inclusion of additional functional ingredients may result in a personal care composition with enhanced performance compared to traditional formulations. The synergistic interaction between the fatty alcohol ethoxylate and alkyl polyglycoside in the flavor solubilizer composition may contribute to these improved characteristics, potentially allowing for more effective delivery of flavors and active ingredients in the final product.

[0125] The present disclosure confirms the advantages of utilizing a mixture of surfactants to enhance flavor solubilization, foam boosting, and formulation stability in personal care compositions, such as mouthwash formulations.

[0126] The synergistic interaction between fatty alcohol ethoxylates and alkyl polyglycosides enables the replacement of entirely synthetic surfactants with surfactants derived from renewable sources. This substitution not only maintains a high level of performance but also allows for the use of lower surfactant concentrations, which may reduce the overall cost of the final formulation.

[0127] The association of different nonionic surfactants has been demonstrated to provide multiple benefits for mouthwash formulations. Notably, the foam volume generated by the mixture is positively impacted, and the smaller bubble size contributes to a creamy texture, which may enhance the sensory experience for the end user during application.

[0128] Furthermore, the formulation process employs a low shear energy method combined with the direct addition of flavor. This approach minimizes the carbon footprint of the formulation by eliminating the need for organic solvents in the solubilization of the active ingredient, thereby aligning with sustainable and environmentally friendly practices.

[0129] The following clauses illustrated example subject matter described herein.

[0130] Clause 1. A flavor solubilizer composition for mouthwash, comprising: a fatty alcohol ethoxylate; an alkyl polyglycoside; and a flavor compound, wherein the fatty alcohol ethoxylate and alkyl polyglycoside are present in a synergistic ratio that enhances solubilization and stability of the flavor compound.

[0131] Clause 2. The flavor solubilizer composition of Clause 1, wherein the fatty alcohol ethoxylate is ceteareth-25.

[0132] Clause 3. The flavor solubilizer composition of any one of Clauses 1 through 2, wherein the alkyl polyglycoside is decyl glucoside.

[0133] Clause 4. The flavor solubilizer composition of any one of Clauses 1 through 3, wherein the synergistic ratio of fatty alcohol ethoxylate to alkyl polyglycoside is between 0.2: 1 and 5: 1.

[0134] Clause 5. The flavor solubilizer composition of any one of Clauses 1 through 4, further comprising a block copolymer of ethylene oxide and propylene oxide.

[0135] Clause 6. The flavor solubilizer composition of any one of Clauses 1 through 5, wherein the flavor compound comprises at least one of menthol, methyl salicylate, peppermint oil, or eucalyptol.

[0136] Clause 7. The flavor solubilizer composition of any one of Clauses 1 through 6, wherein the composition is prepared using a low shear energy method allowing direct addition of the flavor compound.

[0137] Clause 8. A method of preparing a flavor-solubilized mouthwash composition, comprising: combining a premix containing oral care active ingredients with a surfactant blend comprising a fatty alcohol ethoxylate and an alkyl polyglycoside; adding a flavor compound to the combination; and mixing the combination with water using a low shear energy method.

[0138] Clause 9. The method of Clause 8, wherein the fatty alcohol ethoxylate is ceteareth- 25 and the alkyl polyglycoside is decyl glucoside.

[0139] Clause 10. The method of any one of Clauses 8 through 9, wherein the surfactant blend comprises the fatty alcohol ethoxylate and the alkyl polyglycoside in a ratio between 0.2: 1 and 5: 1.

[0140] Clause 11. The method of any one of Clauses 8 through 10, wherein the premix comprises at least one of cetylpyridinium chloride, sodium fluoride, or sodium saccharin.

[0141] Clause 12. The method of any one of Clauses 8 through 11, wherein the flavor compound comprises at least one of menthol, methyl salicylate, peppermint oil, or eucalyptol.

[0142] Clause 13. The method of any one of Clauses 8 through 12, further comprising adding a block copolymer of ethylene oxide and propylene oxide to the combination.

[0143] Clause 14. The method of any one of Clauses 8 through 13, wherein the low shear energy method comprises magnetic stirring at room temperature for about 20 minutes.

[0144] Clause 15. A mouthwash composition, comprising: a premix containing oral care active ingredients; a surfactant blend comprising a fatty alcohol ethoxylate and an alkyl polyglycoside; a flavor compound; and water, wherein the surfactant blend is present in an amount effective to solubilize the flavor compound and enhance foam volume and stability.

[0145] Clause 16. The mouthwash composition of Clause 15, wherein the fatty alcohol ethoxylate is ceteareth-25 and the alkyl polyglycoside is decyl glucoside.

[0146] Clause 17. The mouthwash composition of any one of Clauses 15 through 16, wherein the surfactant blend comprises the fatty alcohol ethoxylate and the alkyl polyglycoside in a ratio between 0.2: 1 and 5: 1.

[0147] Clause 18. The mouthwash composition of any one of Clauses 15 through 17, wherein the premix comprises at least one of cetylpyridinium chloride, sodium fluoride, or sodium saccharin.

[0148] Clause 19. The mouthwash composition of any one of Clauses 15 through 18, wherein the flavor compound comprises at least one of menthol, methyl salicylate, peppermint oil, or eucalyptol.

[0149] Clause 20. The mouthwash composition of any one of Clauses 15 through 19, further comprising a block copolymer of ethylene oxide and propylene oxide.

[0150] Clause 21. A method of preparing a composition for solubilizing a hydrophobic compound, comprising: (a) combining a first nonionic surfactant, wherein the first nonionic surfactant is ethoxylated, with a second nonionic surfactant, wherein the second nonionic surfactant is an alkyl polyglycoside, to form a solubilizing system; (b) mixing the solubilizing system at a shear rate of below 100 s '; and (c) adding one or more hydrophobic compounds to the solubilizing system; and wherein at least 30wt% of the solubilizing system is derived from one or more biorenewal sources and the one or more hydrophobic compounds is solubilized and stabilized in the composition.

[0151] Clause 22. The method of Clause 21, wherein the hydrophobic compound is a flavor compound.

[0152] Clause 23. The method of Clauses 21 or 22, wherein the hydrophobic compound is a flavor compound comprising at least one of menthol, methyl salicylate, peppermint oil, or eucalyptol.

[0153] Clause 24. The method of any one of Clauses 21 through 23, wherein the first nonionic surfactant is a fatty alcohol ethoxylate and the alkyl polyglycoside is decyl glucoside.

[0154] Clause 25. The method of any one of Clauses 21 through 24, wherein the fatty alcohol ethoxylate is ceteareth-25.

[0155] Clause 26. The method of any one of Clauses 21 through 25, wherein the alkyl polyglycoside is decyl glucoside.

[0156] Clause 27. A method of preparing a composition for solubilizing a hydrophobic compound, comprising: (a) combining a solubility system comprising a first nonionic surfactant and a second nonionic surfactant, wherein the first nonionic surfactant is ethoxylated, and the second nonionic surfactant is an alkyl polyglycoside, with a premix containing personal care active ingredients; (b) mixing the solubilizing system and the premix at a shear rate of below 100 s'1; and (c) adding one or more hydrophobic compounds to the solubilizing system; wherein at least 30wt% of the solubilizing system is derived from one or more biorenewal sources and the one or more hydrophobic compounds is solubilized and stabilized in the composition.

[0157] Clause 28. The method of Clause 27, wherein the first nonionic surfactant is a fatty alcohol ethoxylate and the second nonionic surfactant is decyl glucoside.

[0158] Clause 29. The method of any one of Clauses 27 or 28, wherein the fatty alcohol ethoxylate is ceteareth-25.

[0159] Clause 30. The method of any one of Clauses 27 through 29, wherein the premix comprises at least one of cetylpyridinium chloride, sodium fluoride, or sodium saccharin.

[0160] Clause 31. The method of any one of Clauses 27 through 30, wherein the hydrophobic compound is a flavor compound comprising at least one of menthol, methyl salicylate, peppermint oil, or eucalyptol.

[0161] Clause 32. The method of any one of Clauses 27 through 31, wherein the first nonionic surfactant is a block copolymer of ethylene oxide and propylene oxide.

[0162] Clause 33. The method of any one of Clauses 27 through 32, wherein the shear rate is between 10 s'1and 50 s'1.

[0163] Clause 34. A composition for flavor solubilization comprising a premix and a synergistic combination of non-ionic surfactants, wherein the synergistic combination of nonionic surfactants comprises at least one of a fatty alcohol ethoxylate and a block copolymer, wherein the composition achieves solubilization efficiency and stability of one or more flavor compounds.

[0164] Clause 35. The composition of Clause 34, wherein at least one of the non-ionic surfactants is derived from one or more biorenewable sources.

[0165] Clause 36. The composition of Clauses 34 or 35, wherein the synergistic combination of non-ionic surfactants further comprises an alkyl polyglycoside.

[0166] Clause 37. The composition of any one of Clauses 34 through 36, wherein the synergistic combination of non-ionic surfactants further comprises a decyl polyglycoside.

[0167] Clause 38. The composition of any one of Clauses 34 through 37, wherein the synergistic combination of non-ionic surfactants comprises a fatty alcohol ethoxylate.

[0168] Clause 39. The composition of any one of Clauses 34 through 38, wherein the synergistic combination of non-ionic surfactants comprises a block copolymer.

[0169] Clause 40. The composition of any one of Clauses 34 through 39, wherein the synergistic combination of non-ionic surfactants comprises a block copolymer, the block copolymer being an ethylene oxide / propylene oxide (EO / PO) copolymer.

[0170] Clause 41. The composition of any one of Clauses 34 through 40, wherein the premix is 18-22 wt% of the composition, the synergistic combination of non-ionic surfactants is 0.2-2 wt% of the composition.

[0171] Clause 42. The composition of any one of Clauses 34 through 41, further comprising one or more flavor compounds, wherein the one or more flavor compounds is 0.15- 0.25 wt% of the composition.

[0172] Clause 43. The composition of any one of Clauses 34 through 42, further comprising water.

[0173] Clause 44. The composition of any one of Clauses 34 through 43, further comprising one or more flavor compounds and water, wherein the premix is 18-22 wt% of the composition, the synergistic combination of non-ionic surfactants is 0.2-2 wt% of the composition, the one or more flavor compounds is 0.15-0.25 wt% of the composition, and water q.s.p.

[0174] Clause 45. A method for preparing a composition for flavor solubilization comprising mixing a premix and a synergistic combination of non-ionic surfactants using a shear rate of not more than 100 s'1, wherein the synergistic combination of non-ionic surfactants comprises at least one of a fatty alcohol ethoxylate and a block copolymer, wherein the composition achieves solubilization efficiency and stability of one or more flavor compounds.

[0175] While the disclosure has been described in connection with what is presently considered to be the most practical and preferred embodiments, it is to be understood that the disclosure is not to be limited to the disclosed embodiments, but on the contrary, is intended to cover various modifications and equivalent arrangements included within the spirit and scope of the appended claims, which scope is to be accorded the broadest interpretation so as to encompass all such modifications and equivalent structures as permitted under the law. Furthermore, it should be understood that while the use of the word preferable, preferably, or preferred in the description above indicates that feature so described may be more desirable, it nonetheless may not be necessary and any embodiment lacking the same may be contemplated as within the scope of the disclosure, that scope being defined by the claims that follow. In reading the claims it is intended that when words such as “a,” “an,” “at least one” and “at least a portion” are used, there is no intention to limit the claim to only one item unless specifically stated to the contrary in the claim. Further, when the language “at least a portion” and / or “a portion” is used the item may include a portion and / or the entire item unless specifically stated to the contrary.

[0176] A number of implementations have been described. Nevertheless, it will be understood that various modifications may be made without departing from the spirit and scope of the disclosure. Accordingly, other implementations are within the scope of the following claims.

Claims

CLAIMSWhat is claimed is:

1. A solubilizing composition, comprising:(a) a first nonionic surfactant, wherein the first nonionic surfactant is ethoxylated; and(b) a second nonionic surfactant, wherein the second nonionic surfactant is an alkyl polyglycoside; wherein at least 30wt% of the solubilizing composition is derived from one or more renewable sources and the solubilizing composition solubilizes and stabilizes one or more hydrophobic compounds.

2. The solubilizing composition of claim 1, wherein the first nonionic surfactant is a fatty alcohol ethoxylate.

3. The solubilizing composition of claim 1, wherein the first nonionic surfactant is ceteareth-25.

4. The solubilizing composition of claim 1, wherein the alkyl polyglycoside is decyl glucoside.

5. The solubilizing composition of claim 1, wherein the ratio of the first nonionic surfactant to the second nonionic surfactant is between 0.2: 1 and 5: 1.

6. The solubilizing composition of claim 1, wherein the first nonionic surfactant is a block copolymer of ethylene oxide and propylene oxide.

7. The solubilizing composition of claim 1, wherein at least 50wt% of the solubilizing composition is derived from one or more renewal sources.

8. A composition for solubilizing a hydrophobic compound, comprising:(a) one or more hydrophobic compounds; and(b) a solubilizing system, comprising:(i) a first nonionic surfactant, wherein the first nonionic surfactant is ethoxylated; and(ii) a second nonionic surfactant, wherein the second nonionic surfactant is an alkyl polyglycoside; and wherein at least 30wt% of the solubilizing system is derived from one or more renewable sources and the one or more hydrophobic compounds is solubilized and stabilized in the composition.

9. The composition of claim 8, wherein the hydrophobic compound is a flavor compound.

10. The composition of claim 8, wherein the hydrophobic compound comprises at least one of menthol, methyl salicylate, peppermint oil, or eucalyptol.

11. The composition of claim 8, wherein the first nonionic surfactant is a fatty alcohol ethoxylate.

12. The composition of claim 8, wherein the first nonionic surfactant is ceteareth-25.

13. The composition of claim 8, wherein the alkyl polyglycoside is decyl glucoside.

14. The composition of claim 8, wherein the ratio of the first nonionic surfactant to the second nonionic surfactant is between 0.2: 1 and 5: 1.

15. A personal care composition, comprising:(a) a solubilizing system, comprising:(i) a first nonionic surfactant, wherein the first nonionic surfactant is ethoxylated; and(ii) a second nonionic surfactant, wherein the second nonionic surfactant is an alkyl polyglycoside;(b) one or more hydrophobic compounds; and(c) water; wherein at least 30wt% of the solubilizing system is derived from one or more renewable sources and the one or more hydrophobic compounds is solubilized and stabilized in the composition.

16. The personal care composition of claim 15, wherein the personal care composition is a mouthwash.

17. The personal care composition of claim 15, wherein the hydrophobic compound is a flavor compound.

18. The personal care composition of claim 15, wherein the first nonionic surfactant is a fatty alcohol ethoxylate and the alkyl polyglycoside is decyl glucoside.

19. The personal care composition of claim 15, wherein the first nonionic surfactant is ceteareth-25.

20. The personal care composition of claim 15, further comprising at least one of cetylpyridinium chloride, sodium fluoride, or sodium saccharin.

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