Quinolinone compounds and uses thereof

Abstract

Provided herein are quinolinone compounds for modulating muscle myosin to treat obesity and related disorders such as cardiovascular diseases, type 2 diabetes, obstructive sleep apnea, cancer, and osteoarthritis.

Description

QUINOLINONE COMPOUNDS AND USES THEREOFCROSS-REFERENCE

[0001] This application claims the benefit of U.S. Provisional Application No. 63 / 570,076 filed March 26, 2024 and U.S. Provisional Application No. 63 / 702,565 filed October 2, 2024, each which is hereby incorporated by reference in its entirety herein.BACKGROUND OF THE INVENTION

[0002] Obesity is a medical condition involving excess body fat accumulated to such an extent that it can potentially have negative effects on health. Obesity is a major cause of disability and is correlated with various diseases and conditions, particularly cardiovascular diseases, type 2 diabetes, obstructive sleep apnea, certain types of cancer, and osteoarthritis. Obesity is a leading preventable cause of death worldwide, with increasing rates in adults and children. In 2022, over 1 billion people were obese worldwide. Excess body fat underlies 64% of cases of diabetes in men and 77% of cases in women.SUMMARY OF THE INVENTION

[0003] In an aspect, the present disclosure provides a compound represented by Formulas (I), (I-A), (II), (II-A), (III), (IV), or (V).

[0004] A compound represented by Formula (I-A)or a salt thereof, wherein:X1, X2, X3, and X4are independently selected from C(R°) and N; each R° is independently selected from: hydrogen, halogen, -NO2, -CN, -N3, -OR8, -SR8, -N(R8)2, -C(O)R8, -C(O)N(R8)2, -N(R8)C(O)R8, -N(R8)C(O)N(R8)2, -OC(O)N(R8)2, -N(R8)C(O)OR8, -C(O)OR8, - OC(O)R8, -S(O)R8, and -S(O)2R8;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8, -SR8, - N(R8)2, -C(O)R8, -C(O)N(R8)2, -N(R8)C(O)R8, -C(O)OR8, -OC(O)R8, - N(R8)C(O)N(R8)2, -OC(O)N(R8)2, -N(R8)C(O)OR8, -S(O)R8, -S(O)2R8, -NO2, =0, =s,=N(R8), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R7; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8, - SR8, -N(R8)2, -C(O)R8, -C(O)N(R8)2, -N(R8)C(O)R8-N(R8)C(O)N(R8)2, -OC(O)N(R8)2, -N(R8)C(O)OR8, -C(O)OR8, -OC(O)R8, -S(O)R8, -S(O)2R8, -NO2, =0, =S, =N(R8), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R7;R1is selected from: hydrogen;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8a, -SR8a, - N(R8a)2, -C(O)R8a, -C(O)N(R8a)2, -N(R8a)C(O)R8a, -C(O)OR8a, -OC(O)R8a, - N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, -N(R8a)C(O)OR8a, -S(O)R8a, -S(O)2R8a, -NO2, =0, =S, =N(R8a), -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3- 10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7a; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R8a, - SR8a, -N(R8a)2, -C(0)R8a, -C(O)N(R8a)2, -N(R8a)C(O)R8a, -N(R8a)C(O)N(R8a)2, - OC(O)N(R8a)2, -N(R8a)C(O)OR8a, -C(0)0R8a, -0C(0)R8a, -S(O)R8a, -S(O)2R8a, -N02, =0, =S, =N(R8a), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R7a; orR1together with R2form a C3-10 cycloalkyl, C5-10 cycloalkenyl, 3- to 10- membered heterocycloalkyl, or 5- to 10-membered heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R8a, -SR8a, -N(R8a)2, -C(0)R8a, -C(O)N(R8a)2, -N(R8a)C(O)R8a, - N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, -N(R8a)C(O)OR8a, -C(0)0R8a, -0C(0)R8a, - S(O)R8a, -S(O)2R8a, -N02, =0 , =S, =N(R8a), -CN, Ci-6alkyl, C2.6alkenyl, and C2.6alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R7a;R2is selected from: hydrogen;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8b, -SR8b, - N(R8b)2, -C(O)R8b, -C(O)N(R8b)2, -N(R8b)C(O)R8b-C(O)OR8b, -OC(O)R8b, - N(R8b)C(O)N(R8b)2, -OC(O)N(R8b)2, -N(R8b)C(O)OR8b, -S(O)R8b, -S(O)2R8b, -NO2, =0, =S, =N(R8b), -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3- 10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7b; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R8b, - SR8b, -N(R8b)2, -C(0)R8b, -C(O)N(R8b)2, -N(R8b)C(O)R8b-N(R8b)C(O)N(R8b)2, - OC(O)N(R8b)2, -N(R8b)C(O)OR8b, -C(0)0R8b, -0C(0)R8b, -S(O)R8b, -S(O)2R8b, -N02, =0, =S, =N(R8b), -CN, -N3, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7b; orR1together with R2form a C3-10 cycloalkyl, C5-10 cycloalkenyl, 3- to 10- membered heterocycloalkyl, or 5- to 10-membered heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R8a, -SR8a, -N(R8a)2, -C(0)R8a, -C(O)N(R8a)2, -N(R8a)C(O)R8a, - N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, -N(R8a)C(O)OR8a, -C(0)0R8a, -0C(0)R8a, - S(O)R8a, -S(O)2R8a, -NO2, =0 , =S, =N(R8a), -CN, Ci-6alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R7a; orR2together with R3form a 3- to 15-membered heterocycloalkyl or 5- to 15- membered heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R8a, -SR8a, -N(R8a)2, -C(0)R8a, - C(O)N(R8a)2, -N(R8a)C(O)R8a, -N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, - N(R8a)C(O)OR8a, -C(0)0R8a, -0C(0)R8a, -S(O)R8a, -S(O)2R8a, -N02, =0-, =S, =N(R8a), -CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10- membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7b;R3is selected from: hydrogen; andCi-6 alkyl optionally substituted with one or more substituents independently selected from R7c; orR2together with R3form a 3- to 15-membered heterocycloalkyl or 5- to 15- membered heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8a, -SR8a, -N(R8a)2, -C(O)R8a, - C(O)N(R8a)2, -N(R8a)C(O)R8a, -N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, - N(R8a)C(O)OR8a, -C(O)OR8a, -OC(O)R8a, -S(O)R8a, -S(O)2R8a, -NO2, =0-, =S, =N(R8a), -CN, Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10- membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7b;R4is selected from: halogen, -0R8d, -SR8d, -N(R8d)2, -N02, and -CN;C3-6 alkyl optionally substituted with one or more substituents independently selected from R7d; and-CH2F, -CHF2, and C2-6 alkyl optionally substituted with one or more -F;C1-6 alkyl substituted with one or more substituents independently selected from - Cl, -Br, -0R8d, -SR8d, -N(R8d)2, -N02, and -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycleis optionally substituted with one or more substituents independently selected from R7d; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from R7d; orR4and R4atogether form a C4-10 carbocycle, or 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, or 3- to 10-membered heterocycle, is optionally substituted with one or more substituents independently selected from R7e;R4ais selected from: hydrogen, halogen, -0R8e, -SR8e, -N(R8e)2, -N02, and -CN; and-CH2F, -CHF2, and C2-6 alkyl optionally substituted with one or more -F;C1-6 alkyl optionally substituted with one or more substituents independently selected from-Cl, -Br, -0R8e, -SR8e, -N(R8e)2, -N02, and -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-memberedheterocycle, are each optionally substituted with one or more substituents independently selected from R7e; or R4and R4atogether form a C4-10 carbocycle, or 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, or 3- to 10-membered heterocycle, is optionally substituted with one or more substituents independently selected from R7e;R5is selected from: hydrogen, halogen, -OR8f, -SR8f, -N(R8f)2, -NO2, -CN, C1-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C1-6 alkyl, C3-10 carbocycle, and 3- to 10- membered heterocycle are each optionally substituted with one or more substituents independently selected from R7f;R6is selected from: hydrogen; andC1-6 alkyl optionally substituted with one or more substituents independently selected from R7g; each R7, R7a, R7b, R7c, R7d, R7e, R7f, and R7gis independently selected from: hydrogen, halogen, -CN, -OH, -SH, -NO2, -NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, - N(CI-6 alkyl)2, and -NH(CI-6 alkyl); andC1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10- membered heterocycle, and Ci-e haloalkyl; each R8, R8a, R8b, R8c, R8d, R8e, and R8fis independently selected from: hydrogen, halogen, -CN, -OH, -SH, -NO2, -NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, - N(CI-6 alkyl)2, and -NH(CI-6 alkyl); andC1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-e alkynyl, C3-10 carbocycle, 3- to 10- membered heterocycle, and Ci-e haloalkyl.INCORPORATION BY REFERENCE

[0005] All publications, patents, and patent applications mentioned in this specification are herein incorporated by reference to the same extent as if each individual publication, patent, or patent application was specifically and individually indicated to be incorporated by reference.DETAILED DESCRIPTION OF THE INVENTION

[0006] While preferred embodiments of the present invention have been shown and described herein, it will be obvious to those skilled in the art that such embodiments are provided by way of example only. Numerous variations, changes, and substitutions will now occur to those skilled in the art without departing from the invention. It should be understood that various alternatives to the embodiments of the invention described herein may be employed in practicing the invention. It is intended that the following claims define the scope of the invention and that methods and structures within the scope of these claims and their equivalents be covered thereby.Definitions

[0007] Unless defined otherwise, all technical and scientific terms used herein have the same meaning as is commonly understood by one of skill in the art to which this invention belongs.

[0008] As used in the specification and claims, the singular form “a”, “an” and “the” includes plural references unless the context clearly dictates otherwise.

[0009] The term “Cx-y” or “Cx-Cy” (e.g., when used in conjunction with a chemical moiety, such as alkyl, alkenyl, or alkynyl) is meant to include groups that comprise a number of carbon atoms greater than or equal to x carbon atoms and less than or equal to y carbon atoms in the chemical moiety, subject to the following. The term “Cx.y” or “Cx-Cy” is not meant to limit the number of carbon atoms which may be attached to the chemical moiety when the chemical moiety is substituted with a second chemical moiety. For example, the term “C1-6 alkyl” or “Ci to Ce alkyl” refers to saturated, substituted or unsubstituted, hydrocarbon groups, including straight-chain alkyl groups (e.g., linear alkyl groups) and branched alkyl groups that contain 1, 2, 3, 4, 5, or 6 carbon atoms, plus however many carbon atoms may be present in any substituents of the C1-6 alkyl. For example, if a C1-6 alkyl is optionally substituted with a second chemical moiety comprising twocarbon atoms, then it will be understood that the Ci-6 alkyl can include between 1 and 8 carbon atoms.

[0010] The terms “Cx-yalkenyl” and “Cx-yalkynyl” refer to substituted or unsubstituted unsaturated aliphatic groups analogous in length and possible substitution to the alkyls described above, but that contain at least one double or triple bond, respectively.

[0011] " Amino" refers to the -NH2 moiety.

[0012] "Cyano" refers to the -CN moiety.

[0013] "Nitro" refers to the -NO2 moiety.

[0014] " Oxa" refers to the -O- moiety.

[0015] " Oxo" refers to the =0 moiety.

[0016] " Thioxo" refers to the =S moiety.

[0017] " Imino" refers to the =N-H moiety.

[0018] " Oximo" refers to the =N-0H moiety.

[0019] "Hydrazino" refers to the =N-NH2 moiety.

[0020] "Alkyl" refers to a straight (e.g., linear) or branched (e.g., nonlinear) hydrocarbon moiety consisting solely of carbon and hydrogen atoms, fully saturated. In certain embodiments, “alkyl” comprises one to fifteen carbon atoms (e.g., C1-C15 alkyl). In certain embodiments, an alkyl comprises one to thirteen carbon atoms (e.g., C1-C13 alkyl). In certain embodiments, an alkyl comprises one to eight carbon atoms (e.g., Ci-Cs alkyl). In certain embodiments, an alkyl comprises one to six carbon atoms (e.g., Ci-Ce alkyl). In other embodiments, an alkyl comprises one to five carbon atoms (e.g., C1-C5 alkyl). In other embodiments, an alkyl comprises one to four carbon atoms (e.g., C1-C4 alkyl). In other embodiments, an alkyl comprises one to three carbon atoms (e.g., C1-C3 alkyl). In other embodiments, an alkyl comprises one to two carbon atoms (e.g., C1-C2 alkyl). In other embodiments, an alkyl comprises one carbon atom (e.g., Ci alkyl, e.g., methyl). In other embodiments, an alkyl comprises five to fifteen carbon atoms (e.g., C5-C15 alkyl). In other embodiments, an alkyl comprises five to eight carbon atoms (e.g., Cs-Cs alkyl). In other embodiments, an alkyl comprises two to five carbon atoms (e.g., C2-C5 alkyl). In other embodiments, an alkyl comprises three to five carbon atoms (e.g., C3-C5 alkyl). In other embodiments, the alkyl group is selected from methyl, ethyl, 1 -propyl ( / / -propyl), 1 -methylethyl (2- propyl, / .w-propyl), 1 -butyl ( / / -butyl), 1 -methylpropyl (.scc-butyl), 2-methylpropyl ( / .w-butyl), 1,1 -dimethylethyl (tert-butyl), and 1 -pentyl ( / / -pentyl). The alkyl is attached to the rest of the molecule by a single bond.

[0021] “Aminoalkyl” refers to a moiety bonded through a nitrogen atom of the form -N(H)(alkyl) or N(alkyl)(alkyl), wherein when the moiety is N(alkyl)(alkyl), the two alkyl groups bonded to nitrogen can be the same alkyl groups or different alkyl groups.

[0022] "Alkoxy" refers to a moiety bonded through an oxygen atom of the formula -O-alkyl, where alkyl is an alkyl chain as defined above.

[0023] "Alkenyl" refers to a straight (e.g., linear) or branched (e.g., nonlinear) hydrocarbon moiety consisting solely of carbon and hydrogen atoms, the moiety comprising at least one carbon-carbon double bond. In certain embodiments, an alkenyl comprises two to twelve carbon atoms. In certain embodiments, an alkenyl comprises two to eight carbon atoms. In other embodiments, an alkenyl comprises two to four carbon atoms. The alkenyl is attached to the rest of the molecule by a single bond, for example, ethenyl (e.g., vinyl), prop-l-enyl (e.g., allyl), but-l-enyl, pent-l-enyl, penta- 1,4-dienyl, and the like.

[0024] "Alkynyl" refers to a straight (e.g., linear) or branched (e.g., nonlinear) hydrocarbon moiety consisting solely of carbon and hydrogen atoms, the moiety comprising at least one carbon-carbon triple bond. In some embodiments, an alkynyl comprises from two to twelve carbon atoms. In some embodiments, an alkynyl optionally further comprises at least one carbon-carbon double bond. In certain embodiments, an alkynyl comprises two to eight carbon atoms. In other embodiments, an alkynyl comprises two to six carbon atoms. In other embodiments, an alkynyl comprises two to four carbon atoms. The alkynyl is attached to the rest of the molecule by a single bond, for example, ethynyl, propynyl, butynyl, pentynyl, hexynyl, and the like.

[0025] “Alkylene” or “alkylene chain” refers to a linear (e.g., straight), or branched (e.g., nonlinear), divalent, hydrocarbon moiety. An “alkylene” or “alkylene chain” can link a portion of the molecule to a second moiety. An “alkylene” or “alkylene chain” consists solely of carbon and hydrogen atoms (substitution of an alkylene with one or more substituents comprising atoms other than hydrogen, such as N, O, and S, may be specified). An “alkylene” or “alkylene chain” can contain no unsaturation (notwithstanding the points of attachment of an alkylene to the rest of the molecule). In certain embodiments, the “alkylene” or “alkylene chain” comprises one to twelve carbon atoms, for example, methylene, ethylene, propylene, ^-butylene, and the like. The alkylene chain can be attached to the portion of the molecule through a single bond and to the second moiety through a single bond. The points of attachment of an alkylene chain to the rest of the molecule and to the second moiety can be through one carbon atom in the alkylene chain or can be through any two carbon atoms within the alkylene. In certain embodiments, an alkylene comprises one to eight carbon atoms (e.g., Ci-Cs alkylene). In other embodiments, an alkylene comprises one to five carbon atoms (e.g., C1-C5 alkylene). In other embodiments, an alkylene comprises one to fourcarbon atoms (e.g., C1-C4 alkylene). In other embodiments, an alkylene comprises one to three carbon atoms (e.g., C1-C3 alkylene). In other embodiments, an alkylene comprises one to two carbon atoms (e.g., C1-C2 alkylene). In other embodiments, an alkylene comprises one carbon atom (e.g., Ci alkylene). In other embodiments, an alkylene comprises five to eight carbon atoms (e.g., Cs-Cs alkylene). In other embodiments, an alkylene comprises two to five carbon atoms (e.g., C2- C5 alkylene). In other embodiments, an alkylene comprises three to five carbon atoms (e.g., C3-C5 alkylene).

[0026] "Alkenylene" or "alkenylene chain" refers to a linear (e.g., straight), or branched, divalent, hydrocarbon moiety. An "alkenylene" or "alkenylene chain" can link a portion of the molecule to a second moiety. An "alkenylene" or "alkenylene chain" consists solely of carbon and hydrogen atoms (substitution of an alkenylene with one or more substituents comprising atoms other than hydrogen, such as N, O, and S, may be specified). An "alkenylene" or "alkenylene chain" comprises at least one carbon-carbon double bond. In certain embodiments, an "alkenylene" or "alkenylene chain" comprises from two to twelve carbon atoms. The alkenylene chain can be attached to the portion of the molecule through a single bond and to the second moiety through a single bond. The points of attachment of an alkenylene chain to the rest of the molecule and to the second moiety can be through one carbon atom in the alkenylene chain or through any two carbon atoms within the alkenylene chain. In certain embodiments, an alkenylene comprises two to eight carbon atoms (e.g., C2-C8 alkenylene). In other embodiments, an alkenylene comprises two to five carbon atoms (e.g.,C2-C5 alkenylene). In other embodiments, an alkenylene comprises two to four carbon atoms (e.g.,C2-C4 alkenylene). In other embodiments, an alkenylene comprises two to three carbon atoms (e.g.,C2-C3 alkenylene). In other embodiments, an alkenylene comprises five to eight carbon atoms (e.g.,C5-C8 alkenylene). In other embodiments, an alkenylene comprises two to five carbon atoms (e.g.,C2-C5 alkenylene). In other embodiments, an alkenylene comprises three to five carbon atoms (e.g., C3-C5 alkenylene).

[0027] "Alkynylene" or "alkynylene chain" refers to a linear (e.g., straight), or branched, divalent, hydrocarbon moiety. An “alkynylene" or "alkynylene chain" can link a portion of the molecule to a second moiety. An “alkynylene" or "alkynylene chain" consists solely of carbon and hydrogen (substitution of an alkynylene with one or more substituents comprising atoms other than hydrogen, such as N, O, and S, may be specified). An “alkynylene" or "alkynylene chain" comprises at least one carbon-carbon triple bond. In certain embodiments, an “alkynylene" or "alkynylene chain" comprises from two to twelve carbon atoms. An alkynylene chain can be attached to the portion of the molecule through a single bond and to the second moiety through a single bond. The points of attachment of an alkynylene chain to the rest of the molecule and to the second moiety can bethrough one carbon atom in the alkynylene chain or through any two carbon atoms within the alkynylene chain. In certain embodiments, an alkynylene comprises two to eight carbon atoms (e.g., C2-C8 alkynylene). In other embodiments, an alkynylene comprises two to five carbon atoms (e.g., C2-C5 alkynylene). In other embodiments, an alkynylene comprises two to four carbon atoms (e.g., C2-C4 alkynylene). In other embodiments, an alkynylene comprises two to three carbon atoms e.g., C2-C3 alkynylene). In other embodiments, an alkynylene comprises two carbon atoms e.g., C2 alkynylene). In other embodiments, an alkynylene comprises five to eight carbon atoms e.g., Cs-Cs alkynylene). In other embodiments, an alkynylene comprises three to five carbon atoms e.g., C3- C5 alkynylene).

[0028] The term “carbocycle” as used herein refers to a saturated or unsaturated (e.g., aromatic or nonaromatic unsaturated) ring or ring system in which each atom of the ring is carbon. The term “carbocycle” comprises “aryls,” “cycloalkenyls,” and “cycloalkyls.” For example, the term “carbocycle” includes 3- to 12-membered monocyclic rings (e.g., 3- to 10- membered monocyclic rings) and 4- to 20-membered polycyclic ring systems (e.g., 5- to 15-membered spiro polycyclic ring systems, 5- to 15-membered bridged polycyclic ring systems, or 4- to 15-membered fused polycyclic ring systems). For example, carbocycle includes 4- to 15-membered bicyclic rings (e.g., 5- to 15-membered spiro bicycles, 5- to 15-membered bridged bicyclic ring systems, or 4- to 15- membered fused bicyclic ring systems). For example, carbocycle includes tricyclic ring systems, which may be bridged, fused, spiro, or a combination thereof. For example, carbocycle includes tetracyclic ring systems, which may be bridged, fused, spiro, or a combination thereof. For example, carbocycle includes ring systems that are both fused and bridged; ring systems that are both fused and spiro; ring systems that are both bridged and spiro; and ring systems that are both fused and bridged and are also spiro. Each ring of a polycyclic carbocycle may be selected from saturated and unsaturated (e.g., aromatic or nonaromatic unsaturated) rings. In an exemplary embodiment, an aromatic ring (e.g., phenyl) of a polycyclic carbocycle may be fused to a saturated or unsaturated ring (e.g., cyclohexane, cyclopentane, cyclohexene, or phenyl). A polycyclic carbocycle includes any combination of saturated and unsaturated (e.g., aromatic or nonaromatic unsaturated) rings, as valence permits. For example, polycyclic carbocycles can be spiro bicyclic rings, such as spiropentane. For example, a polycyclic carbocycle includes any combination of ring sizes such as 2-2 spiro ring systems (e.g., spiro[2.2]pentane), 3-3 spiro ring systems, 4-4 spiro ring systems, 4-5 fused ring systems (e.g., bicyclo[4.5.0] fused ring systems), 5-5 fused ring systems, 5-6 fused ring systems, 6-6 fused ring systems (e.g., naphthalene), 5-7 fused ring systems, 6-7 fused ring systems, 5-8 fused ring systems, and 6-8 fused ring systems. Exemplary carbocycles include cyclopentyl, cyclohexyl, cyclohexenyl, adamantyl, phenyl, indanyl, naphthyl, traw -bicyclo[4.4.0]decane, cis-bicylo[4.4.0]decane, spiro[3.4]octane, fluoranthene, and bicyclo[l. l.l]pentanyl. In some embodiments, a carbocycle may be bridged, fused, spiro, or any combination thereof. In some embodiments, a carbocycle is a bridged carbocycle. In some embodiments, a carbocycle is a fused carbocycle. In some embodiments, a carbocycle is a spiro carbocycle. In some embodiments, a carbocycle is a bridged and fused carbocycle. In some embodiments, a carbocycle is a bridged and spiro carbocycle. In some embodiments, a carbocycle is a fused and spiro carbocycle. In some embodiments, a carbocycle is a bridged, fused and spiro carbocycle.

[0029] The term “aryl” refers to an aromatic monocyclic or aromatic polycyclic hydrocarbon ring system comprising at least one cyclic, delocalized (4n+2) ^-electronic system, wherein n is an integer greater than or equal to 0, in accordance with Huckel theory. In some embodiments, the aromatic monocyclic or aromatic polycyclic hydrocarbon ring system comprises only hydrogen atoms and carbon atoms. In some embodiments, the aromatic monocyclic or polycyclic system contains from three to twenty carbon atoms. In some embodiments, at least one of the rings in the polycyclic aromatic ring system is aromatic. In some embodiments, the aromatic monocyclic or aromatic polycyclic hydrocarbon ring system comprises a cyclic, delocalized (4n+2) ^-electronic system in accordance with Huckel theory. In some embodiments, the ring system from which aryl groups are derived include, but are not limited to, groups such as benzene, fluorene, indane, indene, anthracene, tetralin, and naphthalene. In some embodiments, the aryl substituent is not charged (e.g., neutral). In some embodiments, the aryl substituent bears no charges. In some embodiments, the aryl substituent bears no net charge. In some embodiments, the aryl substituent bears no net charge and is not zwitterionic. In some embodiments, none of the carbon atoms of the aryl substituent are charged. In some embodiments, none of the carbon atoms of the aryl substituent are charged.

[0030] The term "cycloalkyl" refers to a saturated ring in which each atom of the ring is carbon. Cycloalkyl may include monocyclic and polycyclic rings such as 3- to 10-membered monocyclic rings, 5- to 12-membered bicyclic rings, 5- to 12-membered spiro bicycles, and 5- to 12-membered bridged rings. In certain embodiments, a cycloalkyl comprises three to ten carbon atoms. In other embodiments, a cycloalkyl comprises three to seven carbon atoms. In other embodiments, a cycloalkyl comprises five to seven carbon atoms. The cycloalkyl may be attached to the rest of the molecule by a single bond. Examples of monocyclic cycloalkyls include, e.g., cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, and cyclooctyl. Examples of polycyclic cycloalkyls include, but are not limited to, adamantyl, spiropentane, norbornyl (e.g., bicyclo[2.2.1]heptanyl), decalinyl, 7,7 dimethyl bicyclo[2.2.1]heptanyl, bicyclofl. l.l]pentanyl, spiropentane, and the like.

[0031] The term "cycloalkenyl" refers to a saturated ring in which each atom of the ring is carbon and there is at least one double bond between two ring carbon atoms. Cycloalkenyl may include monocyclic and polycyclic rings, such as 3- to 10-membered monocyclic rings and 4- to 12- membered bicyclic rings (e.g., 5- to 12-membered bridged bicyclic rings, fused 4- to 12-membered bicyclic rings, and spiro 5- to 12-membered bicyclic rings). In other embodiments, a cycloalkenyl comprises five to seven carbon atoms. The cycloalkenyl may be attached to the rest of the molecule by a single bond. Examples of monocyclic cycloalkenyls include, e.g., cyclopentenyl, cyclohexenyl, cycloheptenyl, and cyclooctenyl.

[0032] The term “halo” or, alternatively, “halogen” or “halide,” means fluoro, chloro, bromo or iodo. In some embodiments, a halo is fluoro, chloro, or bromo. In some embodiments, a halo is a fluoro or a chloro. In some embodiments, a halo is a fluoro. In some embodiments, a halo is a chloro.

[0033] The term “haloalkyl” refers to an alkyl, as defined above, that is substituted by one or more halogens, for example, trifluoromethyl, dichloromethyl, bromomethyl, 2,2,2-trifluoroethyl, l-chloromethyl-2-fluoroethyl, and the like. In some embodiments, the alkyl part of the haloalkyl is optionally further substituted as described herein.

[0034] The term “heterocycle” as used herein refers to a saturated or unsaturated (e.g., aromatic or nonaromatic unsaturated) ring or ring system in which one or more heteroatom(s) is(are) member(s) of the ring or ring system. Exemplary heteroatoms include N, O, Si, P, B, and S atoms. For example, heterocycles include 3- to 12-membered monocyclic rings (e.g., 3- to 10- membered monocyclic rings) and 4- to 20-membered polycyclic ring systems (e.g., 4- to 15-membered fused poly ring systems, 5- to 15-membered spiro polycyclic ring systems, and 5- to 15-membered bridged polycyclic ring systems). In some embodiments, a heterocycle may be bridged, fused, spiro, or any combination thereof. In some embodiments, a heterocycle is a bridged heterocycle. In some embodiments, a heterocycle is a fused heterocycle. In some embodiments, a heterocycle is a spiro heterocycle. In some embodiments, a heterocycle is a bridged and fused heterocycle. In some embodiments, a heterocycle is a bridged and spiro heterocycle. In some embodiments, a heterocycle is a fused and spiro heterocycle. In some embodiments, a heterocycle is a bridged, fused and spiro heterocycle. For example, heterocycles include 4- to 20-membered bicyclic ring systems (e.g., 4- to 15-membered fused bicyclic ring systems, 5- to 15-membered spiro bicyclic ring systems, and 5- to 15-membered bridged bicyclic ring systems). For example, heterocycle includes tricyclic ring systems, which may be bridged, fused, spiro, or a combination thereof. For example, heterocycle includes tetracyclic ring systems, which may be bridged, fused, spiro, or a combination thereof. For example, heterocycle includes ring systems that are both fused and bridged; ring systems that areboth fused and spiro; ring systems that are both bridged and spiro; and ring systems that are both fused and bridged and are also spiro. Each ring of a polycyclic heterocycle may be selected from saturated and unsaturated (e.g., aromatic or nonaromatic unsaturated) rings. A polycyclic heterocycle includes any combination of saturated, and unsaturated (e.g., aromatic or nonaromatic unsaturated) rings, as valence permits. In an exemplary embodiment, an aromatic ring, e.g., pyridyl or phenyl, may be fused to a saturated or unsaturated ring, e.g., cyclohexane, cyclopentane, morpholine, piperidine or cyclohexene, in a heterocycle, as long as at least one atom in the resulting fused ring system is a heteroatom. A polycyclic heterocycle includes any combination of ring sizes such as 3-3 spiro, 4-5 fused ring systems, 5-5 fused ring systems, 5-6 fused ring systems, 6-6 fused ring systems, 5-7 fused ring systems, 6-7 fused ring systems, 5-8 fused ring systems, and 6-8 fused ring systems. A bicyclic heterocycle further includes spiro bicyclic rings, e.g., 5 to 12-membered spiro bicycles, such as 2-oxa-6-azaspiro[3.3]heptane. In some embodiments, a heterocycle comprises multiple heteroatoms. In some embodiments, a heterocycle comprises an atom selected from nitrogen, oxygen, and sulfur. In some embodiments, a heterocycle comprises multiple atoms selected from nitrogen, oxygen, and sulfur. In some embodiments, a heterocycle comprises one or more atom(s) selected from nitrogen, oxygen, and sulfur. In some embodiments, a heterocycle comprises one or more atom(s) selected from nitrogen and oxygen. In some embodiments, a heterocycle comprises one or more atom(s) selected from nitrogen and sulfur. In some embodiments, a heterocycle comprises one or more atom(s) selected from oxygen and sulfur. In some embodiments, a heterocycle comprises one or more atom(s) selected from nitrogen. In some embodiments, a heterocycle comprises one or more atom(s) selected from oxygen. In some embodiments, a heterocycle comprises one or more atom(s) selected from sulfur. In some embodiments, a heterocycle does not comprise Boron in the ring. In some embodiments, a heterocycle does not comprise Phosphorus in the ring. In some embodiments, a heterocycle does not comprise Sulfur in the ring. In some embodiments, a heterocycle does not comprise Oxygen in the ring. In some embodiments, a heterocycle does not comprise Nitrogen in the ring. In some embodiments, a heterocycle comprises only heteroatoms selected from nitrogen, oxygen, and sulfur in the ring, and the heterocycle comprises no other heteroatoms in the ring. Nonlimiting examples of heterocycles include pyridine, pyrrole, indole, carbazole, piperidine, oxazole, morpholine, thiophene, benzothiophene, furan, tetrahydrofuran, and pyran. Nonlimiting examples of heterocycles include azepinyl, acridinyl, benzimidazolyl, benzindolyl, 1,3-benzodioxolyl, benzofuranyl, benzoxazolyl, benzo[d]thiazolyl, benzothiadiazolyl, benzo[Z>][l,4]dioxepinyl, benzo[b][l,4]oxazinyl, 1,4-benzodioxanyl, benzonaphthofuranyl, benzoxazolyl, benzodi oxolyl, benzodioxinyl, benzopyranyl, benzopyranonyl, benzofuranyl, benzofuranonyl, benzothienyl(benzothiophenyl), benzothieno[3,2-d]pyrimidinyl, benzotri azolyl, benzo[4,6]imidazo[l,2-a]pyridinyl, carbazolyl, cinnolinyl, cyclopenta[d]pyrimidinyl,6.7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidinyl, 5,6-dihydrobenzo[h]quinazolinyl, 5,6-dihydrobenzo[h]cinnolinyl, 6,7-dihydro-5H-benzo[6,7]cyclohepta[l,2-c]pyridazinyl, dibenzofuranyl, dibenzothiophenyl, furanyl, furan onyl, furo[3,2-c]pyridinyl,5.6.7.8.9.10-hexahydrocycloocta[d]pyrimidinyl, 5,6,7,8,9,10-hexahydrocycloocta[d]pyridazinyl,5.6.7.8.9.10-hexahydrocycloocta[d]pyridinyl, isothiazolyl, imidazolyl, indazolyl, indolyl, indazolyl, isoindolyl, indolinyl, isoindolinyl, isoquinolyl, indolizinyl, isoxazolyl,5.8-methano-5,6,7,8-tetrahydroquinazolinyl, naphthyridinyl, 1,6-naphthyri dinonyl, oxadiazolyl, 2-oxoazepinyl, oxazolyl, oxiranyl, 5,6,6a,7,8,9,10,10a-octahydrobenzo[h]quinazolinyl,1 -phenyl- 1 / 7-pyrrolyl, phenazinyl, phenothiazinyl, phenoxazinyl, phthalazinyl, pteridinyl, purinyl, pyrrolyl, pyrazolyl, pyrazolo[3,4-d]pyrimidinyl, pyridinyl, pyrido[3,2-d]pyrimidinyl, pyrido[3,4-d]pyrimidinyl, pyrazinyl, pyrimidinyl, pyridazinyl, pyrrolyl, quinazolinyl, quinoxalinyl, quinolinyl, isoquinolinyl, tetrahydroquinolinyl, 5,6,7,8-tetrahydroquinazolinyl,5.6.7.8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidinyl,6.7.8.9-tetrahydro-5H-cyclohepta[4,5]thieno[2,3-d]pyrimidinyl, 5,6,7,8-tetrahydropyrido[4,5-c]pyridazinyl, thiazolyl, thiadiazolyl, triazolyl, tetrazolyl, triazinyl, thieno[2,3-d]pyrimidinyl, thieno[3,2-d]pyrimidinyl, thieno[2,3-c]pyridinyl, and thiophenyl (e.g., thienyl).

[0035] In some embodiments, a heterocycle is attached to the molecule by a carbon atom. In some embodiments, the heterocycle is attached to the molecule by a nitrogen atom.

[0036] In some embodiments, a heterocycle comprises a moiety selected from a heteroaryl, a heterocycloalkyl, and a heterocycloalkenyl. In some embodiments, the heterocycle is a heteroaryl. In some embodiments, the heterocycle is a heterocycloalkyl. In some embodiments, the heterocycle is a heterocycloalkenyl.

[0037] In some embodiments, a heterocycle comprises an atom selected from nitrogen and oxygen. In some embodiments, a heterocycle comprises an atom selected from nitrogen and sulfur. In some embodiments, a heterocycle comprises an atom selected from oxygen and sulfur. In some embodiments, a heterocycle comprises an atom selected from nitrogen. In some embodiments, a heterocycle comprises an atom selected from oxygen. In some embodiments, a heterocycle comprises an atom selected from sulfur.

[0038] In some embodiments, a heterocycle comprises 1 to 8 heteroatoms. In some embodiments, the heterocycle comprises 1 to 5 heteroatoms. In some embodiments, the heterocycle comprises 1 to 3 heteroatoms. In some embodiments, the heterocycle comprises 1 to 2 heteroatoms. In someembodiments, the heterocycle comprises 1 heteroatom. In some embodiments, the heterocycle comprises 2 heteroatoms. In some embodiments, the heterocycle comprises 3 heteroatoms. In some embodiments, the heterocycle comprises 4 heteroatoms. In some embodiments, the heterocycle comprises 5 heteroatoms. In some embodiments, the heterocycle comprises 6 heteroatoms.

[0039] In some embodiments, a heterocycle comprises a 3-memberd ring, 4-membered ring, 5- membered ring, 6-membered ring, 7-membered ring, 8-membered ring, 9-membered ring, 10- membered ring, 11 -membered ring, 12-membered ring, 13 -membered ring, 14-membered ring, or 15-20 membered ring. In some embodiments, a heterocycle is 3- to 10-membered. In some embodiments, a heterocycle is 3- to 6-membered. In some embodiments, a heterocycle is 5- to 6- membered. In some embodiments, a heterocycle is 9- to 10-membered. In some embodiments, a heterocycle is 9- to 11 -membered. In some embodiments, a heterocycle is 9- to 15-membered.

[0040] In some embodiments, the heterocycle is monosubstituted, di substituted, tri substituted, tetrasubstituted, or pentasubstituted (e.g., with further substituents in addition to the point of attachment). In some embodiments, the total number of substituents (e.g., atoms other than hydrogen) on the heterocycle (e.g., bonded to the ring of the heterocycle) is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more.

[0041] In some embodiments, in the molecule or moiety (e.g., in a heterocycle), one or more nitrogen atoms, if present, can be optionally quaternized. In some embodiments, the heterocycle substituent is positively charged, some embodiments, the heterocycle moiety is neutral. In some embodiments, the heterocycle substituent is zwitterionic. Alternatively, or in addition, in some embodiments, the heterocycle substituent is not charged. In some embodiments, the heterocycle substituent bears no charges. In some embodiments, the heterocycle substituent bears no net charge. In some embodiments, no atoms within the heterocycle substituent bear any net charge. In some embodiments, the heterocycle substituent bears no net charge and is not zwitterionic. The term "heteroaryl" refers to a moiety derived from an aromatic monocyclic or aromatic polycyclic ring system, in which one or more heteroatom(s) is(are) member(s) of the ring system, and the ring system comprises at least one cyclic, delocalized (4n+2) ^-electronic system, wherein n is an integer greater than or equal to 0, in accordance with Huckel theory. In some embodiments, one or more heteroatom(s) is(are) member(s) of the ring system comprising the cyclic, delocalized (4n+2) ^-electronic system (e.g., the ring with aromaticity). Exemplary heteroatoms include N, O, Si, P, B, and S atoms. In some embodiments, a heteroaryl comprises an aromatic ring, in which one or more heteroatom(s) is(are) member(s) of the ring system, to which one or more nonaromatic rings, each of which may or may not comprise one or more heteroatom(s), may be fused. In some embodiments, a heteroaryl includes one or more heteroatoms selected from nitrogen, oxygen, andsulfur. In some embodiments, a heteroaryl includes multiple heteroatoms selected from nitrogen, oxygen, and sulfur. In certain embodiments, “heteroaryl” includes rings and ring systems comprising 3 to 20 atoms. In some embodiments, “heteroaryl” includes rings and ring systems that comprise two to seventeen carbon atoms and from one to six heteroatoms selected from nitrogen, oxygen and sulfur. As used herein, the heteroaryl moiety is a monocyclic or polycyclic (e.g., bicyclic, tricyclic or tetracyclic) ring system, wherein at least one of the rings in the ring system is aromatic, e.g., it contains a cyclic, delocalized (4n+2) 7t-electron system in accordance with the Hiickel theory. Heteroaryl includes fused, bridged, and spiro ring systems. The heteroatom(s) in the heteroaryl moiety is(are) optionally oxidized. One or more nitrogen atom(s), if present, is(are) optionally quaternized. The heteroaryl is attached to the rest of the molecule through any atom of the ring(s). Examples of heteroaryls include, but are not limited to, acridinyl, benzimidazolyl, benzindolyl, 1,3-benzodioxolyl, benzofuranyl, benzoxazolyl, benzo[d]thiazolyl, benzothiadiazolyl, benzo[Z>][l,4]dioxepinyl, benzo[b][l,4]oxazinyl, 1,4-benzodioxanyl, benzonaphthofuranyl, benzoxazolyl, benzodioxolyl, benzodioxinyl, benzopyranyl, benzopyranonyl, benzofuranyl, benzofuranonyl, benzothienyl (benzothiophenyl), benzothieno[3,2-d]pyrimidinyl, benzotri azolyl, benzo[4,6]imidazo[l,2-a]pyridinyl, carbazolyl, cinnolinyl, cyclopenta[d]pyrimidinyl,6.7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidinyl, 5,6-dihydrobenzo[h]quinazolinyl, 5,6-dihydrobenzo[h]cinnolinyl, 6,7-dihydro-5H-benzo[6,7]cyclohepta[l,2-c]pyridazinyl, dibenzofuranyl, dibenzothiophenyl, furanyl, furo[3,2-c]pyridinyl,5.6.7.8.9.10-hexahydrocycloocta[d]pyrimidinyl, 5,6,7,8,9,10-hexahydrocycloocta[d]pyridazinyl,5.6.7.8.9.10-hexahydrocycloocta[d]pyridinyl, isothiazolyl, imidazolyl, indazolyl, indolyl, isoindolyl, indolinyl, isoindolinyl, isoquinolyl, indolizinyl, isoxazolyl,5.8-methano-5,6,7,8-tetrahydroquinazolinyl, naphthyridinyl, 1,6-naphthyri dinonyl, oxadiazolyl, oxazolyl, 5,6,6a,7,8,9,10,10a-octahydrobenzo[h]quinazolinyl, 1 -phenyl- 177-pyrrolyl, phenazinyl, phenothiazinyl, phenoxazinyl, phthalazinyl, pteridinyl, purinyl, pyrrolyl, pyrazolyl, pyrazolo[3,4-d]pyrimidinyl, pyridinyl, pyrido[3,2-d]pyrimidinyl, pyrido[3,4-d]pyrimidinyl, pyrazinyl, pyrimidinyl, pyridazinyl, pyrrolyl, quinazolinyl, quinoxalinyl, quinolinyl, isoquinolinyl, tetrahydroquinolinyl, 5,6,7,8-tetrahydroquinazolinyl,5.6.7.8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidinyl,6.7.8.9-tetrahydro-5H-cyclohepta[4,5]thieno[2,3-d]pyrimidinyl, 5,6,7,8-tetrahydropyrido[4,5-c]pyridazinyl, thiazolyl, thiadiazolyl, triazolyl, tetrazolyl, triazinyl, thieno[2,3-d]pyrimidinyl, thieno[3,2-d]pyrimidinyl, thieno[2,3-c]pyridinyl, and thiophenyl (e.g., thienyl). In some embodiments, further examples of “heteroaryl” include 5, 6,7,8- tetrahydroquinoline; l,2,3,4-tetrahydro-l,8-naphthyridine; 6,7-dihydro-5H-cyclopenta[b]pyridine;2,3-dihydro-lH-pyrrolo[2,3-b]pyridine; 4,5,6,7-tetrahydrobenzofuran; 4,5,6,7-tetrahydrofuro[2,3- b]pyridine; 5,6-dihydro-4H-cyclopenta[b]furan; 4,5-dihydrothieno[2,3-b]furan. In some embodiments, the heteroaryl substituent is positively or negatively charged. In some embodiments, the heteroaryl substituent is neutral. In some embodiments, the heteroaryl substituent is zwitterionic; alternatively, or in addition, in some embodiments, the heteroaryl substituent is not charged. In some embodiments, the heteroaryl substituent bears no charges. In some embodiments, the heteroaryl substituent bears no net charge. In some embodiments, the heteroaryl substituent bears no net charge and is not zwitterionic.

[0042] The term “heterocycle” comprises “heteroaryls,” “heterocycloalkenyls,” and “heterocycloalkyls.”

[0043] The term "heterocycloalkyl" refers to a moiety comprising a saturated ring (e.g., a ring with only single bonds connecting the members of the ring), wherein the saturated ring comprises carbon atom(s) and one or more heteroatom(s) as member(s) of the saturated ring, and wherein the saturated ring may be optionally fused, bridged with, or spiro to an additional ring, wherein the additional ring may comprise only carbon atoms as members of the additional ring or wherein the additional ring may comprise one or more heteroatom(s) as member(s) of the additional ring. In some embodiments, a heterocycloalkyl may be covalently bound to one or more carbocycle(s) or heterocycle(s). Exemplary heteroatoms include N, O, Si, P, B, and S atoms. Heterocycloalkyl may include monocyclic and polycyclic rings such as 3- to 10-membered monocyclic rings, 6- to 12- membered bicyclic rings, 5- to 12-membered spiro bicycles, or 5- to 12-membered bridged rings. The heteroatoms in the heterocycloalkyl radical are optionally oxidized. One or more nitrogen atoms, if present, are optionally quatemized. The heterocycloalkyl is attached to the rest of the molecule through any atom of the heterocycloalkyl, valence permitting, such as any carbon or nitrogen atoms of the heterocycloalkyl. Examples of heterocycloalkyl radicals include, but are not limited to, dioxolanyl, thienyl[l,3]dithianyl, decahydroisoquinolyl, imidazolinyl, imidazolidinyl, isothiazolidinyl, isoxazolidinyl, morpholinyl, octahydroindolyl, octahydroisoindolyl, 2-oxopiperazinyl, 2-oxopiperidinyl, 2-oxopyrrolidinyl, oxazolidinyl, piperidinyl, piperazinyl, 4-piperidonyl, pyrrolidinyl, pyrazolidinyl, quinuclidinyl, thiazolidinyl, tetrahydrofuryl, trithianyl, tetrahydropyranyl, thiomorpholinyl, thiamorpholinyl, 1-oxo-thiomorpholinyl, 2-oxa-6- azaspiro[3.3]heptane, and 1,1-dioxo-thiomorpholinyl. In some embodiments, a heterocycloalkyl comprises one heteroatom. In some embodiments, a heterocycloalkyl comprises one heteroatom selected from N, O, and S. In some embodiments, a heterocycloalkyl comprises multiple heteroatoms. In some embodiments, a heterocycloalkyl comprises multiple heteroatoms selected from N, O, and S.

[0044] The term "heterocycloalkenyl" refers to a moiety comprising an unsaturated ring (e.g., a ring with either single bonds or double bonds connecting the members of the ring): wherein the unsaturated ring comprises carbon atoms and one or more heteroatom(s); wherein the unsaturated ring may be optionally fused, bridged with, or spiro to an additional ring, wherein the additional ring may comprise only carbon atoms as members of the additional ring or wherein the additional ring may comprise one or more heteroatom(s) as member(s) of the additional ring; and wherein there is at least one double bond between two ringcarbon atoms (e.g., carbon atoms that are members of the unsaturated ring). Heterocycloalkenyl does not include heteroaryl rings. Exemplary heteroatoms include N, O, Si, P, B, and S atoms. Heterocycloalkenyl may include monocyclic and polycyclic rings such as 3- to 10-membered monocyclic rings, 6- to 12-membered bicyclic rings, and 5- to 12-membered bridged rings. In other embodiments, a heterocycloalkenyl comprises five to seven ring atoms. The heterocycloalkenyl may be attached to the rest of the molecule by a single bond. Examples of monocyclic cycloalkenyls include, e.g., pyrroline (dihydropyrrole), pyrazoline (dihydropyrazole), imidazoline (dihydroimidazole), triazoline (dihydrotriazole), dihydrofuran, dihydrothiophene, oxazoline (dihydrooxazole), isoxazoline (dihydroisoxazole), thiazoline (dihydrothiazole), isothiazoline (dihydroisothiazole), oxadiazoline (dihydrooxadiazole), thiadiazoline (dihydrothiadiazole), dihydropyridine, tetrahydropyridine, dihydropyridazine, tetrahydropyridazine, dihydropyrimidine, tetrahydropyrimidine, dihydropyrazine, tetrahydropyrazine, pyran, dihydropyran, thiopyran, dihydrothiopyran, dioxine, dihydrodioxine, oxazine, dihydrooxazine, thiazine, and dihydrothiazine.

[0045] A “spirocyclic” moiety (e.g., a “spiro” moiety) (e.g., a spirocyclic heterocycle, a spirocyclic heterocycloalkenyl, a spirocyclic carbocycle, a spirocyclic heterocycloalkyl, a spirocyclic cycloalkenyl, or a spirocyclic cycloalkyl) is a polycyclic system (e.g., bicyclic, tricyclic, tetracyclic) system wherein two rings share exactly one atom. Examples of spirocyclic moieties include, but are

[0046] A spirocyclic heterocycle comprises a spirocyclic moiety that comprises at least one heteroatom in the ring system of the spirocyclic moiety. Examples of spirocyclic heterocycles

[0047] A spirocyclic carbocycle comprises a spirocyclic moiety that comprises only carbon atoms in the ring system of the spirocyclic moiety. Examples of spirocyclic carbocycles include, but are

[0048] A “fused” moiety (e.g., a fused heterocycle, a fused carbocycle, a fused heterocycloalkyl, or a fused cycloalkyl) is a polycyclic system (e.g., bicyclic, tricyclic, tetracyclic) wherein two rings share exactly two atoms. Examples of fused moieties include, but are not limited to:

[0049] A “fused” heterocycle comprises a fused moiety that comprises at least one heteroatom in the ring system of the fused moiety. Examples of fused heterocycles include, but are not limited to:

[0050] A “fused” carbocycle comprises a fused moiety that comprises only carbon atoms in the ring system of the fused moiety. Examples of fused carbocycles include, but are not limited to:

[0051] A “bridged” moiety (e.g., a bridged heterocycle, a bridged carbocycle, a bridged heterocycloalkyl, a bridged heterocycloalkenyl, or a bridged cycloalkyl) is a polycyclic system (e.g., bicyclic, tricyclic, tetracyclic) which comprises two or more bridgeheads, wherein in at least one combination of two bridgeheads, each bridgehead in the combination of two bridgeheads is separated from the other bridgehead in the combination of two bridgeheads by three bridges, each bridge comprising at least one atom, wherein each of the three bridges does not contain any of the same atoms as either of the other two bridges.

[0052] In some embodiments, a “bridged” moiety (e.g., a bridged heterocycle, a bridged carbocycle, a bridged heterocycloalkyl, a bridged heterocycloalkenyl, or a bridged cycloalkyl) is a polycyclic system (e.g., bicyclic, tricyclic, tetracyclic) which comprises two or more bridgeheads, wherein in at least one pair of bridgeheads, each bridgehead in the pair is separated from the other bridgehead in the pair by three bridges, each bridge comprising at least one atom, wherein each of the three bridges does not contain any of the same atoms as either of the other two bridges.

[0053] In some embodiments, a bridgehead atom is a .s / hybridized carbon or nitrogen atom that forms a nexus between two or more rings. In some embodiments, a bridge comprises one or more atom(s) connecting two bridgehead atoms.

[0054] Examples of bridged moieties include, but are not limited to:(bicyclo[l. l.l]pentane),(bicyclo[2.1.1]hexane), norbornane (2-oxa-5-azabicyclo[2.2.1]heptanebicyclo[3.1.1 ]heptane, bicyclo[2.2.2]octane, twistanespiro[bicyclo[2.2.1]heptane-7,l'-cyclopropane],spiro[bicyclo[2.2. l]heptane-

[0055] A “bridged” carbocycle comprises a bridged moiety that comprises only carbon atoms in the ring system of the bridged moiety. Examples of bridged carbocycles include, but are not limited to:(bicyclof 1.1.1 ]pentane),(bicyclo[2.1.1]hexane), norbornane (y . . p bicyclo[2.2.2]octane, twistanespiro[bicyclo[2.2.1]heptane-7,l'-cyclopropane], andspiro[bicyclo[2.2.1]heptane-2,l'-cyclopropane].

[0056] A “bridged” heterocycle comprises a bridged moiety that comprises at least one heteroatom in the ring system of the bridged moiety. Examples of bridged heterocycles include, but are not

[0057] The term “substituted” refers to moieties having substituents replacing a hydrogen on one or more carbon atom(s) or substitutable heteroatoms, e.g., an NH or NH2 of a compound. It will be understood that “substitution” or “substituted with” includes the implicit proviso that such substitution is in accordance with permitted valence of the substituted atom and the substituent and further includes the proviso that the substitution results in a stable compound, e.g., a compound which does not rapidly undergo rearrangement, cyclization, elimination, etc. In certain embodiments, substituted refers to moieties having substituents replacing two hydrogen atoms on the same carbon atom, such as substituting the two hydrogen atoms on a single carbon atom with an oxo, imino, oxime, hydrazone, or thioxo group. As used herein, the term “substituted” is contemplated to include all permissible substituents of organic compounds. In a broad aspect, the permissible substituents include acyclic and cyclic, branched and unbranched, carbocyclic andheterocyclic, aromatic and non-aromatic substituents of organic compounds. The permissible substituents can be one or more and the same or different for appropriate organic compounds.

[0058] In some embodiments, the term “one or more substituents” may refer to one substituent, or two substituents, or three substituents, or four substituents, or five substituents, or six substituents, or more than six substituents. In some embodiments, the term “one or more substituents” may refer to one substituent. In some embodiments, the term “one or more substituents” may refer to two substituents. In some embodiments, the term “one or more substituents” may refer to three substituents. In some embodiments, the term “one or more substituents” may refer to four substituents. In some embodiments, the term “one or more substituents” may refer to five substituents. In some embodiments, the term “one or more substituents” may refer to more than five substituents. In some embodiments, the term “one or more substituents” may refer to 1 substituent to 10 substituents. In some embodiments, the term “one or more substituents” may refer to at least 1 substituent. In some embodiments, the term “one or more substituents” may refer to at most 10 substituents. In some embodiments, the term “one or more substituents” may refer to at most 5 substituents. In some embodiments, the term “one or more substituents” may refer to at most 2 substituents. In some embodiments, the term “one or more substituents” may refer to 1 substituent to 2 substituents. In some embodiments, the term “one or more substituents” may refer to 1 substituent to 1 substituent. 1 substituent to 3 substituents, 1 substituent to 4 substituents, 1 substituent to 5 substituents, 1 substituent to 6 substituents, 1 substituent to 7 substituents, 1 substituent to 10 substituents, 2 substituents to 3 substituents, 2 substituents to 4 substituents, 2 substituents to 5 substituents, 2 substituents to 6 substituents, 2 substituents to 7 substituents, 2 substituents to 10 substituents, 3 substituents to 4 substituents, 3 substituents to 5 substituents, 3 substituents to 6 substituents, 3 substituents to 7 substituents, 3 substituents to 10 substituents, 4 substituents to 5 substituents, 4 substituents to 6 substituents, 4 substituents to 7 substituents, 4 substituents to 10 substituents, 5 substituents to 6 substituents, 5 substituents to 7 substituents, 5 substituents to 10 substituents, 6 substituents to 7 substituents, 6 substituents to 10 substituents, or 7 substituents to 10 substituents. In some embodiments, the term “one or more substituents” may refer to 1 substituent, 2 substituents, 3 substituents, 4 substituents, 5 substituents, 6 substituents, 7 substituents, or 10 substituents.

[0059] In some embodiments, substituents may include any substituents described herein, for example: halogen, hydroxy, oxo (=0), thioxo (=S), cyano (-CN), nitro (-NO2), imino (=N-H), oximo (=N-0H), hydrazino (=N-NH2), -Rb-ORa, -Rb-OC(O)-Ra, -Rb-OC(O)-ORa, - Rb-OC(O)-N(Ra)2, -Rb-N(Ra)2, -Rb-C(O)Ra, -Rb-C(O)ORa, -Rb-C(O)N(Ra)2, -Rb-O-Rc-C(O)N(Ra)2, - Rb-N(Ra)C(O)ORa, -Rb-N(Ra)C(O)Ra, -Rb-N(Ra)S(O)tRa(where t is 1 or 2), -Rb-S(O)tRa(where t is1 or 2), -Rb-S(O)tORa(where t is 1 or 2), and -Rb-S(O)tN(Ra)2 (where t is 1 or 2); and alkyl, alkenyl, alkynyl, aryl, aralkyl, aralkenyl, aralkynyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, and heteroarylalkyl, any of which may be optionally substituted by alkyl, alkenyl, alkynyl, halogen, haloalkyl, haloalkenyl, haloalkynyl, oxo (=0), thioxo (=S), cyano (-CN), nitro (-NO2), imino (=N-H), oximo (=N-0H), hydrazine (=N-NH2), -Rb-0Ra, - Rb-0C(0)-Ra, -Rb-0C(0)-0Ra, -Rb-0C(0)-N(Ra)2, -Rb-N(Ra)2, -Rb-C(0)Ra, -Rb-C(0)0Ra, - Rb-C(0)N(Ra)2, -Rb-0-Rc-C(0)N(Ra)2, -Rb-N(Ra)C(0)0Ra, -Rb-N(Ra)C(0)Ra, -Rb-N(Ra)S(O)tRa(where t is 1 or 2), -Rb-S(O)tRa(where t is 1 or 2), -Rb-S(O)tORa(where t is 1 or 2) and - Rb-S(0)tN(Ra)2 (where t is 1 or 2); wherein each Rais independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, or heteroarylalkyl, wherein each Ra, valence permitting, may be optionally substituted with alkyl, alkenyl, alkynyl, halogen, haloalkyl, haloalkenyl, haloalkynyl, oxo (=0), thioxo (=S), cyano (-CN), nitro (-NO2), imino (=N-H), oximo (=N-0H), hydrazine (=N-NH2), -Rb-0Ra, -Rb-0C(0)-Ra, - Rb-0C(0)-0Ra, -Rb-0C(0)-N(Ra)2, -Rb-N(Ra)2, -Rb-C(0)Ra, -Rb-C(0)0Ra, -Rb-C(0)N(Ra)2, - Rb-0-Rc-C(0)N(Ra)2, -Rb-N(Ra)C(0)0Ra, -Rb-N(Ra)C(0)Ra, -Rb-N(Ra)S(O)tRa(where t is 1 or 2), - Rb-S(O)tRa(where t is 1 or 2), -Rb-S(O)tORa(where t is 1 or 2) and -Rb-S(0)tN(Ra)2 (where t is 1 or 2); and wherein each Rbis independently selected from a direct bond or a straight or branched alkylene, alkenylene, or alkynylene chain, and each Rcis a straight or branched alkylene, alkenylene or alkynylene chain. In some embodiments, substituents may include, for example, - N(Ra)C(0)N(Ra)2-.

[0060] Double bonds to oxygen atoms, such as oxo groups, are represented herein as both “=O” and “(O)”. Double bonds to nitrogen atoms are represented as both “=NR” and “(NR)”. Double bonds to sulfur atoms are represented as both “=S” and “(S)”.

[0061] The phrases “parenteral administration” and “administered parenterally” as used herein means modes of administration other than enteral and topical administration, usually by injection, and includes, without limitation, intravenous, intramuscular, intra-arterial, intrathecal, intracapsular, intraorbital, intracardiac, intradermal, intraperitoneal, transtracheal, subcutaneous, subcuticular, intraarticular, subcapsular, subarachnoid, intraspinal and intrastemal injection and infusion.

[0062] The phrase “pharmaceutically acceptable” is employed herein to refer to those compounds, materials, compositions, and / or dosage forms which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of human beings and animals without excessive toxicity, irritation, allergic response, or other problem or complication, commensurate with a reasonable benefit / risk ratio.

[0063] The phrase “pharmaceutically acceptable excipient” or “pharmaceutically acceptable carrier” as used herein means a pharmaceutically acceptable material, composition or vehicle, such as a liquid or solid filler, diluent, excipient, solvent or encapsulating material. Each carrier must be “acceptable” in the sense of being compatible with the other ingredients of the formulation and not injurious to the patient. Some examples of materials which can serve as pharmaceutically acceptable carriers include: (1) sugars, such as lactose, glucose and sucrose; (2) starches, such as com starch and potato starch; (3) cellulose, and its derivatives, such as sodium carboxymethyl cellulose, ethyl cellulose and cellulose acetate; (4) powdered tragacanth; (5) malt; (6) gelatin; (7) talc; (8) excipients, such as cocoa butter and suppository waxes; (9) oils, such as peanut oil, cottonseed oil, safflower oil, sesame oil, olive oil, corn oil and soybean oil; (10) glycols, such as propylene glycol; (11) polyols, such as glycerin, sorbitol, mannitol and polyethylene glycol; (12) esters, such as ethyl oleate and ethyl laurate; (13) agar; (14) buffering agents, such as magnesium hydroxide and aluminum hydroxide; (15) alginic acid; (16) pyrogen-free water; (17) isotonic saline; (18) Ringer's solution; (19) ethyl alcohol; (20) phosphate buffer solutions; and (21) other non-toxic compatible substances employed in pharmaceutical formulations.

[0064] The term “salt” or “pharmaceutically acceptable salt” refers to salts derived from a variety of organic and inorganic counter ions well known in the art. Pharmaceutically acceptable acid addition salts can be formed with inorganic acids and / or organic acids. Inorganic acids from which salts can be derived include, for example, hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid, and the like. Organic acids from which salts can be derived include, for example, acetic acid, propionic acid, glycolic acid, pyruvic acid, oxalic acid, maleic acid, malonic acid, succinic acid, fumaric acid, tartaric acid, citric acid, benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, -toluenesulfonic acid, salicylic acid, and the like. Pharmaceutically acceptable base addition salts can be formed with inorganic and / or organic bases. Inorganic bases from which salts can be derived include, for example, sodium, potassium, lithium, ammonium, calcium, magnesium, iron, zinc, copper, manganese, aluminum, and the like. Organic bases from which salts can be derived include, for example, primary, secondary, and tertiary amines, substituted amines including naturally occurring substituted amines, cyclic amines, basic ion exchange resins, and the like, specifically such as isopropylamine, trimethylamine, diethylamine, triethylamine, tripropylamine, and ethanolamine. In some embodiments, the pharmaceutically acceptable base addition salt is selected from ammonium, potassium, sodium, calcium, and magnesium salts.

[0065] As used herein, “treatment” or “treating” refers to an approach for obtaining beneficial or desired results with respect to a disease, disorder, or medical condition including but not limited to atherapeutic benefit and / or a prophylactic benefit. A therapeutic benefit can include, for example, the eradication or amelioration of the underlying disorder being treated. Also, a therapeutic benefit can include, for example, the eradication or amelioration of one or more of the physiological symptoms associated with the underlying disorder such that an improvement is observed in the subject, notwithstanding that the subject may still be afflicted with the underlying disorder. In certain embodiments, for prophylactic benefit, the compositions are administered to a subject at risk of developing a particular disease, or to a subject reporting one or more of the physiological symptoms of a disease, even though a diagnosis of this disease may not have been made. Treatment via administration of a compound described herein does not require the involvement of a medical professional.

[0066] Chemical entities having carbon-carbon double bonds or carbon-nitrogen double bonds may exist in Z- or E- form (or cis- or trans- form). Furthermore, some chemical entities may exist in various tautomeric forms. Unless otherwise specified, all structures described herein are intended to disclose, implicitly or explicitly, all Z-, A- and tautomeric forms as well.

[0067] A “tautomer” refers to a molecule wherein a proton shift from one atom of a molecule to another atom of the same molecule is possible. The compounds presented herein, in certain embodiments, exist as tautomers. In circumstances where tautomerization is possible, a chemical equilibrium of the tautomers will exist. The exact ratio of the tautomers depends on several factors, including physical state, temperature, solvent, and pH. Some examples of tautomeric equilibria include, but are not limited to:

[0068] The compounds disclosed herein, in some embodiments, are used in different enriched isotopic forms, e.g., enriched in the content of2H,3H,nC,13C and / or14C. In one particularembodiment, the compound is deuterated in at least one position. Such deuterated forms can be made by the procedure described in U.S. Patent Nos. 5,846,514 and 6,334,997. As described in U.S. Patent Nos. 5,846,514 and 6,334,997, deuteration can improve the metabolic stability and or efficacy of drugs, thus increasing the duration of action of drugs.

[0069] Unless otherwise stated, compounds described herein are intended to include compounds which differ only in the presence of one or more isotopically enriched atoms. For example, compounds having the present structures except for the replacement of one or more proton(s) by one or more deuterium(deuteria) or tritium(tritia), or combinations thereof, or except for the replacement of one or more12C atom(s) in the structure by one or more13C atom(s), one or more14C atom(s), or combinations thereof, in the structure are within the scope of the present disclosure.

[0070] The compounds of the present disclosure optionally comprise unnatural proportions of atomic isotopes at one or more atom(s) that constitute such compounds. For example, the compounds may be labeled with one or more isotope(s), such as for example, deuterium (2H), tritium (3H), iodine-125 (125I) or carbon-14 (14C). Isotopic substitution with2H,3H,nC,13C,14C,15C,12N,13N,15N,16N,17O,18O,14F,15F,16F,17F,18F,33S,34S,35S,36S,35C1,37C1,79Br,81Br, and125I are all contemplated. All isotopic variations of the compounds of the present invention, whether radioactive or not, are encompassed within the scope of the present invention.

[0071] In certain embodiments, the compounds disclosed herein have some or all of theJH atoms replaced with2H atoms. The methods of synthesis for deuterium-containing compounds are known in the art and include, by way of non-limiting example only, the following synthetic methods.

[0072] Deuterium-substituted compounds are synthesized using various methods such as described in: Dean, Dennis C.; Editor. Recent Advances in the Synthesis and Applications of Radiolabeled Compounds for Drug Discovery and Development. [In: Curr., Pharm. Des., 2000; 6(10)] 2000, 110 pp; George W.; Varma, Rajender S. The Synthesis of Radiolabeled Compounds via Organometallic Intermediates, Tetrahedron, 1989, 45(21), 6601-21; and Evans, E. Anthony. Synthesis of radiolabeled compounds, J. Radioanal. Chem., 1981, 64(1-2), 9-32.

[0073] Deuterated starting materials are readily available and are subjected to the synthetic methods described herein to provide for the synthesis of deuterium-containing compounds. Large numbers of deuterium-containing reagents and building blocks are available commercially from chemical vendors, such as MilliporeSigma.

[0074] Included in the present disclosure are salts, particularly pharmaceutically acceptable salts, of the compounds described herein. The compounds of the present disclosure that comprise one or more sufficiently acidic functional group(s), one or more sufficiently basic functional group(s), or both one or more sufficiently acidic functional group(s) and one or more sufficiently basicfunctional group(s) to form a salt (particularly a pharmaceutically acceptable salt), can react with any of a number of inorganic organic bases or inorganic or organic acids, to form a salt. ; combinations thereof); or combinations thereof. Alternatively, compounds that are inherently charged, such as those with a quaternary nitrogen, can form a salt with an appropriate counterion.

[0075] The compounds and salts described herein may in some cases exist as diastereomers, enantiomers, or other stereoisomeric forms. Unless otherwise specified (e.g., in tables of biological data), the structures disclosed herein are intended to include, explicitly or implicitly, disclosure of all diastereomeric (e.g., epimeric) and enantiomeric forms as well as mixtures thereof. Separation of stereoisomers may be performed by chromatography or by forming diastereomers and separating by recrystallization, or chromatography, or any combination thereof. (Jean Jacques, Andre Collet, Samuel H. Wilen, “Enantiomers, Racemates and Resolutions”, John Wiley And Sons, Inc., 1981, herein incorporated by reference for this disclosure). Stereoisomers may also be obtained by stereoselective synthesis.

[0076] In certain embodiments, the compounds or salts of the compounds may be prodrugs. For example, in some embodiments, a hydroxyl in the parent compound is presented as an ester or a carbonate, or carboxylic acid present in the parent compound is presented as an ester. The term “prodrug” is intended to encompass compounds which, under physiologic conditions, are converted into pharmaceutical agents of the present disclosure. One method for making a prodrug is to include one or more selected moi eties which are hydrolyzed under physiologic conditions to reveal the desired molecule. In other embodiments, the prodrug is converted by an enzymatic activity of the host animal such as specific target cells in the host animal. For example, esters or carbonates (e.g., esters or carbonates of alcohols or carboxylic acids and esters of phosphonic acids) may be prodrugs of the present disclosure. In some embodiments, a prodrug for an amine might rely on enzymatic activation. In some embodiments, a prodrug for an amine might rely on physiological chemical conditions for release of the drugs. In some embodiments, a prodrug for an amine may be selected from an amide, a carbonate, an N-acyloxy alkyl derivative, an N-acyloxy carbonyl derivative, a beta-aminoketone, an (oxodioxolenyl)methyl derivative, an N-Mannich base, an imine (e.g., a Schiff base), an enamine, an enaminone, an azo compound, a system capable of undergoing lactonization, a tetrahydrothiadiazine-2-thione, a redox system, or a PEG.

[0077] Prodrug forms of the herein described compounds, wherein the prodrug is metabolized in vivo to produce a compound as set forth herein are included within the scope of the claims. In some cases, some of the herein-described compounds may be a prodrug for another derivative or active compound.

[0078] Prodrugs are often useful because, in some situations, they may be easier to administer than the parent drug. They may, for instance, be bioavailable by oral administration whereas the parent is not. Prodrugs may help enhance the cell permeability of a compound relative to the parent drug. The prodrug may also have improved solubility in pharmaceutical compositions over the parent drug. Prodrugs may be designed as reversible drug derivatives, for use as modifiers to enhance drug transport to site-specific tissues or to increase drug residence inside of a cell.

[0079] In some embodiments, the design of a prodrug increases the lipophilicity of the pharmaceutical agent. In some embodiments, the design of a prodrug increases the effective water solubility. See, e.g., Fedorak et al., Am. J. Physiol., 269:G210-218 (1995); McLoed c / a / ., Gastroenterol, 106:405-413 (1994); Hochhaus et al., Biomed. Chrom., 6:283-286 (1992); J. Larsen and H. Bundgaard, Int. J. Pharmaceutics, 37, 87 (1987); J. Larsen et al., Int. J. Pharmaceutics, 47, 103 (1988); Sinkula et al., J. Pharm. Sci., 64: 181-210 (1975); T. Higuchi and V. Stella, Pro-drugs as Novel Delivery Systems, Vol. 14 of the A.C.S. Symposium Series; and Edward B. Roche, Bioreversible Carriers in Drug Design, American Pharmaceutical Association and Pergamon Press, 1987, all incorporated herein for such disclosure). According to another embodiment, the present disclosure provides methods of producing the above-defined compounds. The compounds may be synthesized using conventional techniques. Advantageously, these compounds are conveniently synthesized from readily available starting materials.

[0080] Synthetic chemistry transformations and methodologies useful in synthesizing the compounds described herein are known in the art and include, for example, those described in R. Larock, Comprehensive Organic Transformations (1989); T. W. Greene and P. G. M.Wuts, Protective Groups in Organic Synthesis, 2d. Ed. (1991); L. Fieser and M. Fieser, Fieser and Fieser ’s Reagents for Organic Synthesis (1994); and L. Paquette, ed., Encyclopedia of Reagents for Organic Synthesis (1995).Compounds

[0081] The following is a discussion of compounds and salts thereof that may be used in the methods of the disclosure. In certain embodiments, the compounds and salts are described in Formulas Formula (I-A), (I), (II), (II-A), (III), (IV), and (V).

[0082] In an aspect, provided herein is compound represented by Formula (I-A)or a salt thereof, wherein:X1, X2, X3, and X4are independently selected from C(R°) and N; each R° is independently selected from: hydrogen, halogen, -NO2, -CN, -N3, -OR8, -SR8, -N(R8)2, -C(O)R8, -C(O)N(R8)2, -N(R8)C(O)R8, -N(R8)C(O)N(R8)2, -OC(O)N(R8)2, -N(R8)C(O)OR8, -C(O)OR8, - OC(O)R8, -S(O)R8, and -S(O)2R8;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8, -SR8, - N(R8)2, -C(O)R8, -C(O)N(R8)2, -N(R8)C(O)R8, -C(O)OR8, -OC(O)R8, - N(R8)C(O)N(R8)2, -OC(O)N(R8)2, -N(R8)C(O)OR8, -S(O)R8, -S(O)2R8, -NO2, =0, =s, =N(R8), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R7; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8, - SR8, -N(R8)2, -C(O)R8, -C(O)N(R8)2, -N(R8)C(O)R8-N(R8)C(O)N(R8)2, -OC(O)N(R8)2, -N(R8)C(O)OR8, -C(O)OR8, -OC(O)R8, -S(O)R8, -S(O)2R8, -NO2, =0, =S, =N(R8), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R7;R1is selected from: hydrogen;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R8a, -SR8a, - N(R8a)2, -C(0)R8a, -C(O)N(R8a)2, -N(R8a)C(O)R8a, -C(0)0R8a, -0C(0)R8a, - N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, -N(R8a)C(O)OR8a, -S(O)R8a, -S(O)2R8a, -N02, =0, =S, =N(R8a), -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3- 10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7a; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R8a, - SR8a, -N(R8a)2, -C(0)R8a, -C(O)N(R8a)2, -N(R8a)C(O)R8a, -N(R8a)C(O)N(R8a)2, - OC(O)N(R8a)2, -N(R8a)C(O)OR8a, -C(0)0R8a, -0C(0)R8a, -S(O)R8a, -S(O)2R8a, -N02, =0, =S, =N(R8a), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R7a; orR1together with R2form a C3-10 cycloalkyl, C5-10 cycloalkenyl, 3- to 10- membered heterocycloalkyl, or 5- to 10-membered heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8a, -SR8a, -N(R8a)2, -C(O)R8a, -C(O)N(R8a)2, -N(R8a)C(O)R8a, - N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, -N(R8a)C(O)OR8a, -C(O)OR8a, -OC(O)R8a, - S(O)R8a, -S(O)2R8a, -NO2, =0 , =S, =N(R8a), -CN, Ci-6alkyl, C2.6alkenyl, and C2.6alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R7a;R2is selected from: hydrogen;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8b, -SR8b, - N(R8b)2, -C(O)R8b, -C(O)N(R8b)2, -N(R8b)C(O)R8b-C(O)OR8b, -OC(O)R8b, - N(R8b)C(O)N(R8b)2, -OC(O)N(R8b)2, -N(R8b)C(O)OR8b, -S(O)R8b, -S(O)2R8b, -NO2, =0, =S, =N(R8b), -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3- 10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7b; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R8b, - SR8b, -N(R8b)2, -C(0)R8b, -C(O)N(R8b)2, -N(R8b)C(O)R8b-N(R8b)C(O)N(R8b)2, - OC(O)N(R8b)2, -N(R8b)C(O)OR8b, -C(0)0R8b, -0C(0)R8b, -S(O)R8b, -S(O)2R8b, -N02, =0, =S, =N(R8b), -CN, -N3, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7b; orR1together with R2form a C3-10 cycloalkyl, C5-10 cycloalkenyl, 3- to 10- membered heterocycloalkyl, or 5- to 10-membered heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R8a, -SR8a, -N(R8a)2, -C(0)R8a, -C(O)N(R8a)2, -N(R8a)C(O)R8a, - N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, -N(R8a)C(O)OR8a, -C(0)0R8a, -0C(0)R8a, - S(O)R8a, -S(O)2R8a, -N02, =0 , =S, =N(R8a), -CN, Ci-6alkyl, C2.6alkenyl, and C2.6alkynyl, wherein Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R7a; orR2together with R3form a 3- to 15-membered heterocycloalkyl or 5- to 15- membered heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8a, -SR8a, -N(R8a)2, -C(O)R8a, - C(O)N(R8a)2, -N(R8a)C(O)R8a, -N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, - N(R8a)C(O)OR8a, -C(O)OR8a, -OC(O)R8a, -S(O)R8a, -S(O)2R8a, -NO2, =0-, =S, =N(R8a), -CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10- membered heterocycle, are each optionally substituted with one or more substituents independently selected from R713;R3is selected from: hydrogen; andC1-6 alkyl optionally substituted with one or more substituents independently selected from R7c; orR2together with R3form a 3- to 15-membered heterocycloalkyl or 5- to 15- membered heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R8a, -SR8a, -N(R8a)2, -C(0)R8a, - C(O)N(R8a)2, -N(R8a)C(O)R8a, -N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, - N(R8a)C(O)OR8a, -C(0)0R8a, -0C(0)R8a, -S(O)R8a, -S(O)2R8a, -N02, =0-, =S, =N(R8a), -CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10- membered heterocycle, are each optionally substituted with one or more substituents independently selected from R713;R4is selected from: halogen, -0R8d, -SR8d, -N(R8d)2, -N02, and -CN;C3-6 alkyl optionally substituted with one or more substituents independently selected from R7d; and-CH2F, -CHF2, and C2-6 alkyl optionally substituted with one or more -F;C1-6 alkyl substituted with one or more substituents independently selected from -Cl, -Br, -0R8d, -SR8d, -N(R8d)2, -NO2, and -CN, C3-10 carbocycle, and 3- to 10- membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycleis optionally substituted with one or more substituents independently selected from R7d; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from R7d; orR4and R4atogether form a C4-10 carbocycle, or 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, or 3- to 10-membered heterocycle, is optionally substituted with one or more substituents independently selected from R7e;R4ais selected from: hydrogen, halogen, -OR8e, -SR8e, -N(R8e)2, -NO2, and -CN; and-CH2F, -CHF2, and C2-6 alkyl optionally substituted with one or more -F;C1-6 alkyl optionally substituted with one or more substituents independently selected from-Cl, -Br, -OR8e, -SR8e, -N(R8e)2, -NO2, and -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7e; or R4and R4atogether form a C4-10 carbocycle, or 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, or 3- to 10-membered heterocycle, is optionally substituted with one or more substituents independently selected from R7e;R5is selected from: hydrogen, halogen, -OR8f, -SR8f, -N(R8f)2, -NO2, -CN, C1-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C1-6 alkyl, C3-10 carbocycle, and 3- to 10- membered heterocycle are each optionally substituted with one or more substituents independently selected from R7f;R6is selected from: hydrogen; andC1-6 alkyl optionally substituted with one or more substituents independently selected from R7g; each R7, R7a, R7b, R7c, R7d, R7e, R7f, and R7gis independently selected from: hydrogen, halogen, -CN, -OH, -SH, -NO2, -NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, - N(CI-6 alkyl)2, and -NH(CI-6 alkyl); andC1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10- membered heterocycle, and Ci-e haloalkyl; each R8, R8a, R8b, R8c, R8d, R8e, and R8fis independently selected from: hydrogen, halogen, -CN, -OH, -SH, -NO2, -NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, - N(CI-6 alkyl)2, and -NH(CI-6 alkyl); andC1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10- membered heterocycle, and Ci-e haloalkyl.

[0083] In an aspect, provided herein is a compound represented by Formula (I)or a salt thereof, wherein:X1, X2, X3, and X4are independently selected from C(R°) and N; each R° is independently selected from: hydrogen, halogen, -NO2, -CN, -N3, -OR8, -SR8, -N(R8)2, -C(0)R8, -C(O)N(R8)2, -N(R8)C(O)R8, -N(R8)C(O)N(R8)2, -OC(O)N(R8)2, -N(R8)C(O)OR8, -C(0)0R8, - 0C(0)R8, -S(O)R8, and -S(O)2R8;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8, -SR8, - N(R8)2, -C(0)R8, -C(O)N(R8)2, -N(R8)C(O)R8, -C(0)0R8, -0C(0)R8, - N(R8)C(O)N(R8)2, -OC(O)N(R8)2, -N(R8)C(O)OR8, -S(O)R8, -S(O)2R8, -NO2, =0, =s, =N(R8), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R7; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8, - SR8, -N(R8)2, -C(O)R8, -C(O)N(R8)2, -N(R8)C(O)R8-N(R8)C(O)N(R8)2, -OC(O)N(R8)2, -N(R8)C(O)OR8, -C(O)OR8, -OC(O)R8, -S(O)R8, -S(O)2R8, -NO2, =0, =S, =N(R8), -CN, Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R7;R1is selected from: hydrogen;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R8a, -SR8a, - N(R8a)2, -C(0)R8a, -C(O)N(R8a)2, -N(R8a)C(O)R8a, -C(0)0R8a, -0C(0)R8a, - N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, -N(R8a)C(O)OR8a, -S(O)R8a, -S(O)2R8a, -N02, =0, =S, =N(R8a), -CN, C3-io carbocycle, and 3- to 10-membered heterocycle, wherein the C3. io carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7a; andC3-io carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8a, - SR8a, -N(R8a)2, -C(O)R8a, -C(O)N(R8a)2, -N(R8a)C(O)R8a, -N(R8a)C(O)N(R8a)2, - OC(O)N(R8a)2, -N(R8a)C(O)OR8a, -C(O)OR8a, -OC(O)R8a, -S(O)R8a, -S(O)2R8a, -NO2, =0, =S, =N(R8a), -CN, Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R7a; orR1together with R2form a C3-io cycloalkyl, C5-10 cycloalkenyl, 3- to 10- membered heterocycloalkyl, or 5- to 10-membered heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8a, -SR8a, -N(R8a)2, -C(0)R8a, -C(O)N(R8a)2, -N(R8a)C(O)R8a, - N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, -N(R8a)C(O)OR8a, -C(0)0R8a, -0C(0)R8a, - S(O)R8a, -S(O)2R8a, -NO2, =0 , =S, =N(R8a), -CN, Ci-6alkyl, C2.6alkenyl, and C2.6alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R7a;R2is selected from: hydrogen;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8b, -SR8b, - N(R8b)2, -C(O)R8b, -C(O)N(R8b)2, -N(R8b)C(O)R8b-C(O)OR8b, -OC(O)R8b, - N(R8b)C(O)N(R8b)2, -OC(O)N(R8b)2, -N(R8b)C(O)OR8b, -S(O)R8b, -S(O)2R8b, -NO2, =0, =S, =N(R8b), -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3- 10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7b; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R8b, - SR8b, -N(R8b)2, -C(0)R8b, -C(O)N(R8b)2, -N(R8b)C(O)R8b-N(R8b)C(O)N(R8b)2, - OC(O)N(R8b)2, -N(R8b)C(O)OR8b, -C(0)0R8b, -0C(0)R8b, -S(O)R8b, -S(O)2R8b, -N02, =0, =S, =N(R8b), -CN, -N3, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7b; orR1together with R2form a C3-10 cycloalkyl, C5-10 cycloalkenyl, 3- to 10- membered heterocycloalkyl, or 5- to 10-membered heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R8a, -SR8a, -N(R8a)2, -C(0)R8a, -C(O)N(R8a)2, -N(R8a)C(O)R8a, - N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, -N(R8a)C(O)OR8a, -C(0)0R8a, -0C(0)R8a, - S(O)R8a, -S(O)2R8a, -NO2, =0 , =S, =N(R8a), -CN, Ci-6alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R7a; orR2together with R3form a 3- to 15-membered heterocycloalkyl or 5- to 15- membered heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R8a, -SR8a, -N(R8a)2, -C(0)R8a, - C(O)N(R8a)2, -N(R8a)C(O)R8a, -N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, - N(R8a)C(O)OR8a, -C(0)0R8a, -0C(0)R8a, -S(O)R8a, -S(O)2R8a, -N02, =0-, =S, =N(R8a), -CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10- membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7b;R3is selected from: hydrogen; andCi-6 alkyl optionally substituted with one or more substituents independently selected from R7c; orR2together with R3form a 3- to 15-membered heterocycloalkyl or 5- to 15- membered heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8a, -SR8a, -N(R8a)2, -C(O)R8a, - C(O)N(R8a)2, -N(R8a)C(O)R8a, -N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, - N(R8a)C(O)OR8a, -C(O)OR8a, -OC(O)R8a, -S(O)R8a, -S(O)2R8a, -NO2, =0-, =S, =N(R8a), -CN, Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10- membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7b;R4is selected from:C3-6 alkyl optionally substituted with one or more substituents independently selected from R7d; and-CH2F, -CHF2, and C2-6 alkyl optionally substituted with one or more -F;C1-6 alkyl substituted with one or more substituents independently selected from - Cl, -Br, -0R8d, -SR8d, -N(R8d)2, -N02, and -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7d; or R4and R4atogether form a C4-10 carbocycle, or 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, or 3- to 10-membered heterocycle, is optionally substituted with one or more substituents independently selected from R7e;R4ais selected from: hydrogen, halogen, -0R8e, -SR8e, -N(R8e)2, -N02, and -CN; and-CH2F, -CHF2, and C2-6 alkyl optionally substituted with one or more -F;C1-6 alkyl optionally substituted with one or more substituents independently selected from -Cl, -Br, -0R8e, -SR8e, -N(R8e)2, -N02, and -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7e; or R4and R4atogether form a C4-10 carbocycle, or 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, or 3- to 10-membered heterocycle, is optionally substituted with one or more substituents independently selected from R7e;R5is selected from: hydrogen, halogen, -OR8f, -SR8f, -N(R8f)2, -NO2, -CN, C1-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C1-6 alkyl, C3-10 carbocycle, and 3- to 10- membered heterocycle are each optionally substituted with one or more substituents independently selected from R7f;R6is selected from: hydrogen; andC1-6 alkyl optionally substituted with one or more substituents independently selected from R7g; each R7, R7a, R7b, R7c, R7d, R7e, R7f, and R7gis independently selected from: hydrogen, halogen, -CN, -OH, -SH, -NO2, -NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, - N(CI-6 alkyl)2, and -NH(CI-6 alkyl); andC1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10- membered heterocycle, and Ci-e haloalkyl; each R8, R8a, R8b, R8c, R8d, R8e, and R8fis independently selected from: hydrogen, halogen, -CN, -OH, -SH, -NO2, -NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, - N(CI-6 alkyl)2, and -NH(CI-6 alkyl); andC1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl.

[0084] In some embodiments, for a compound or salt of Formula (I), or Formula (I- A), X1, X2, X3, and X4are each independently selected from C(R°). In some embodiments, X1, X2, X3, and X4areindependently selected from C(R°) and N. In some embodiments, X1is selected from C(R°) and N. In some embodiments, X2is selected from C(R°) and N. In some embodiments, X3is selected from C(R°) and N. In some embodiments, X4is selected from C(R°) and N. In some embodiments, X1is selected from C(R°) and N. In some embodiments, X3is selected from C(R°) and N. In some embodiments, X4is selected from C(R°) and N. In some embodiments, X1is selected from C(H), C(halogen) and N. In some embodiments, X2is selected from C(H), C(halogen) and N. In some embodiments, X3is selected from C(H), C(halogen) and N. In some embodiments, X4is selected from C(H), C(halogen) and N. In some embodiments, X1is selected from C(H) and C(halogen). In some embodiments, X2is selected from C(H) and C(halogen). In some embodiments, X3is selected from C(H) and C(halogen). In some embodiments, X4is selected from C(H) and C(halogen). In some embodiments, X1is selected from C(H) and C(F). In some embodiments, X2is selected from C(H) and C(F). In some embodiments, X3is selected from C(H) and C(F). In some embodiments, X4is selected from C(H) and C(F). In some embodiments, X1is selected from C(H) and N. In some embodiments, X2is selected from C(H) and N. In some embodiments, X3is selected from C(H) and N. In some embodiments, X4is selected from C(H) and N. In some embodiments, X1is selected from C(H). In some embodiments, X2is selected from C(H). In some embodiments, X3is selected from C(H). In some embodiments, X4is selected from C(H). In some embodiments, X1is selected from N. In some embodiments, X2is selected from N. In some embodiments, X3is selected from N. In some embodiments, X4is selected from N. In some embodiments, X1is selected from C(F). In some embodiments, X2is selected from C(F). In some embodiments, X3is selected from C(F). In some embodiments, X4is selected from C(F). In some embodiments, X3is selected from C(H), and X4is selected from C(H). In some embodiments, X1is selected from C(F), and X2is selected from C(F). In some embodiments, X1is selected from C(H), and X2is selected from C(H). In some embodiments, X1is selected from C(F), and X2is selected from C(H). In some embodiments, X1is selected from C(H), and X2is selected from C(F). In some embodiments, X1is selected from N, and X2is selected from C(H). In some embodiments, X1is selected from C(H), and X2is selected from N. In some embodiments, X1is selected from C(F), and X2is selected from N. In some embodiments, at least one of X1, X2, X3, and X4need not be N.

[0085] In some embodiments, for a compound or salt of Formula (I), or Formula (I- A), X1, X2, X3, and X4are each independently selected from C(R°) and N. In some embodiments, at least one of X1, X2, X3, and X4is N. In some embodiments, at least two of X1, X2, X3, and X4are N. In some embodiments, X1is N. In some embodiments, X2is N. In some embodiments, X3is N. In some embodiments, X4is N. In some embodiments, X1, X2, X3, and X4are each independently selected from: C(H), C(halogen), and N. In some embodiments, X1, X2, X3, and X4are each independentlyselected from: C(H), C(F), and N. In some embodiments, X1, X2, X3, and X4are each independently selected from: C(H) and C(F).

[0086] In some embodiments, for a compound or salt of Formula (I) or Formula (I-A), each R° is independently selected from: hydrogen, halogen, -NO2, -CN, -N3, -OR8, -SR8, -N(R8)2, -C(O)R8, -C(O)N(R8)2, -N(R8)C(O)R8, -N(R8)C(O)N(R8)2, -OC(O)N(R8)2, -N(R8)C(O)OR8, -C(O)OR8, -OC(O)R8, -S(O)R8, and - S(O)2R8;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8, -SR8, -N(R8)2, -C(O)R8, - C(O)N(R8)2, -N(R8)C(O)R8, -C(O)OR8, -OC(O)R8, -N(R8)C(O)N(R8)2, -OC(O)N(R8)2, - N(R8)C(O)OR8, -S(O)R8, -S(O)2R8, -NO2, =0, =S, =N(R8), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R7; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8, -SR8, - N(R8)2, -C(O)R8, -C(O)N(R8)2, -N(R8)C(O)R8, -N(R8)C(O)N(R8)2, -OC(O)N(R8)2, - N(R8)C(O)OR8, -C(O)OR8, -OC(O)R8, -S(O)R8, -S(O)2R8, -NO2, =0, =S, =N(R8), -CN, Ci-6alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R7.

[0087] In some embodiments, for a compound or salt of Formula (I) or Formula (I-A), each R° is independently selected from: hydrogen, halogen, -NO2, -CN, -N3, -OR8, -SR8, -N(R8)2, -C(O)R8, -C(O)N(R8)2, -N(R8)C(O)R8, -OC(O)N(R8)2, -C(O)OR8, -OC(O)R8, and -S(O)2R8;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8, -SR8, -N(R8)2, -C(O)R8, - C(O)N(R8)2, -N(R8)C(O)R8, -C(O)OR8, -OC(O)R8, -N(R8)C(O)N(R8)2, -OC(O)N(R8)2, - N(R8)C(O)OR8, -S(O)R8, -S(O)2R8, =0, =S, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8, -SR8, - N(R8)2, -C(O)R8, -C(O)N(R8)2, -N(R8)C(O)R8, -C(O)OR8, -OC(O)R8, -N(R8)C(O)N(R8)2, - OC(O)N(R8)2, -N(R8)C(O)OR8, -S(O)R8, -S(O)2R8, =0, =S, -CN, C1-6 alkyl, C2.6alkenyl,and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R7.

[0088] In some embodiments, for a compound or salt of Formula (I) or Formula (I-A), each R° is independently selected from: hydrogen, halogen, -NO2, -CN, -N3, -OR8, -SR8, and -N(R8)2;C1-6 alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8, -SR8, -N(R8)2, =0, -CN, C3-10 carbocycle and 3- to 10- membered heterocycle; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8, -SR8, -N(R8)2, =0, -CN, C1-6 alkyl, wherein C1-6 alkyl, optionally substituted with one or more substituents independently selected from R7.

[0089] In some embodiments, for a compound or salt of Formula (I), or Formula (I-A) each R° is independently selected from: hydrogen, -F, -Cl, -Br, -I, -NO2, -CN, -N3, -OR8, -SR8, -N(R8)2, -C(O)R8, -C(O)N(R8)2, -N(R8)C(O)R8, -OC(O)N(R8)2, -C(O)OR8, -OC(O)R8, and -S(O)2R8.

[0090] In some embodiments, each R° is independently selected from: hydrogen, -F, -Cl, -Br, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl. In some embodiments, each R° is independently selected from: methyl, ethyl, w-propyl, and isopropyl. In some embodiments, each R° is hydrogen. In some embodiments, each R° is selected from -H and halogen. In some embodiments, each R° is selected from -H and -F.In some embodiments, for a compound or salt of Formula (I), or Formula (I-A) R1is selected from: hydrogen;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8a, -SR8a, -N(R8a)2, -C(O)R8a, - C(O)N(R8a)2, -N(R8a)C(O)R8a, -C(O)OR8a, -OC(O)R8a, -N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, -N(R8a)C(O)OR8a, -S(O)R8a, -S(O)2R8a, -NO2, =O, =S, =N(R8a), -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7a; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8a, -SR8a, - N(R8a)2, -C(O)R8a, -C(O)N(R8a)2, -N(R8a)C(O)R8a, -N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, - N(R8a)C(O)OR8a, -C(O)OR8a, -OC(O)R8a, -S(O)R8a, -S(O)2R8a, -NO2, =O, =S, =N(R8a), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl areeach optionally substituted with one or more substituents independently selected from R7a; orR1together with R2form a C3-10 cycloalkyl, or 3- to 10-membered heterocycloalkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8a, -SR8a, -N(R8a)2, -C(O)R8a, -C(O)N(R8a)2, -N(R8a)C(O)R8a, - N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, -N(R8a)C(O)OR8a, -C(O)OR8a, -OC(O)R8a, -S(O)R8a, - S(O)2R8a, -NO2, =0 , =S, =N(R8a), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R7a.

[0091] In some embodiments, for a compound or salt of Formula (I), or Formula (I-A) R1is selected from: hydrogen;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8a, - N(R8a)2, -C(O)R8a, -C(O)N(R8a)2, -N(R8a)C(O)R8a, -C(O)OR8a, -OC(O)R8a, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7a; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8a, - N(R8a)2, -C(O)R8a, -C(O)N(R8a)2, -N(R8a)C(O)R8a, -C(O)OR8a, -OC(O)R8a, -CN, Ci-6alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R7a; orR1together with R2form a C3-10 carbocycle, or 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8a, -N(R8a)2, -C(O)R8a, -C(O)N(R8a)2, - N(R8a)C(O)R8a, -C(O)OR8a, -OC(O)R8a, -CN, Ci-6alkyl, C2.6alkenyl, and C2.6alkynyl, wherein Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R7a.

[0092] In some embodiments, for a compound or salt of Formula (I), or Formula (I-A) R1is selected from: hydrogen;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8a, - N(R8a)2, -C(O)R8a, -C(O)N(R8a)2, -N(R8a)C(O)R8a, -C(O)OR8a, -OC(O)R8a, -CN, C3-6 carbocycle, and 3- to 6-membered heterocycle, wherein the C3-6 carbocycle, and 3- to 6- membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7a; andC3-6 carbocycle, and 3- to 6-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8a, - N(R8a)2, -C(O)R8a, -C(O)N(R8a)2, -N(R8a)C(O)R8a, -C(O)OR8a, -OC(O)R8a, -CN, Ci-6alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R7a.

[0093] In some embodiments, for a compound or salt of Formula (I), or Formula (I- A) R1together with R2form a C3-6 carbocycle, or 3- to 6-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8a, -N(R8a)2, -C(O)R8a, -C(O)N(R8a)2, -N(R8a)C(O)R8a, -C(O)OR8a, -OC(O)R8a, -CN, Ci-6alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R7a.

[0094] In some embodiments, for a compound or salt of Formula (I), or Formula (I-A) R1is selected from: methyl, ethyl, w-propyl, and isopropyl. In some embodiments, R1is hydrogen. In some embodiments, R1is methyl. In some embodiments, for a compound or salt of Formula (I), or Formula (I-A) R2is selected from: hydrogen;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8b, -SR8b, - N(R8b)2, -C(O)R8b, -C(O)N(R8b)2, -N(R8b)C(O)R8b-C(O)OR8b, -OC(O)R8b, - N(R8b)C(O)N(R8b)2, -OC(O)N(R8b)2, -N(R8b)C(O)OR8b, -S(O)R8b, -S(O)2R8b, -NO2, =0, =S, =N(R8b), -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3- 10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7b; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8b, - SR8b, -N(R8b)2, -C(O)R8b, -C(O)N(R8b)2, -N(R8b)C(O)R8b-N(R8b)C(O)N(R8b)2, - OC(O)N(R8b)2, -N(R8b)C(O)OR8b, -C(O)OR8b, -OC(O)R8b, -S(O)R8b, -S(O)2R8b, -NO2, =0, =S, =N(R8b), -CN, -N3, Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3-to 10-membered heterocycle, wherein Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7b; orR2together with R3form a C3-10 cycloalkyl, or 3- to 15-membered heterocycloalkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8a, -SR8a, -N(R8a)2, -C(O)R8a, -C(O)N(R8a)2, - N(R8a)C(O)R8a, -N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, -N(R8a)C(O)OR8a, -C(O)OR8a, - OC(O)R8a, -S(O)R8a, -S(O)2R8a, -NO2, =0-, =S, =N(R8a), -CN, Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein C1-6 alkyl, C2- 6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7b;

[0095] In some embodiments, for a compound or salt of Formula (I), or Formula (I-A) R2is selected from: hydrogen;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8b, - N(R8b)2, -C(O)R8b, -C(O)N(R8b)2, -N(R8b)C(O)R8b-C(O)OR8b, -OC(O)R8b, -S(O)2R8b, - NO2, =0, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7b; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8b, - N(R8b)2, -C(O)R8b, -C(O)N(R8b)2, -N(R8b)C(O)R8b-C(O)OR8b, -OC(O)R8b, -S(O)2R8b, - NO2, =0, -CN, -N3, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10- membered heterocycle, wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7b; orR2together with R3form a C3-10 carbocycle, or 3- to 15-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8b, -N(R8b)2, -C(0)R8b, -C(O)N(R8b)2, - N(R8b)C(O)R8b-C(0)0R8b, -0C(0)R8b, -S(O)2R8b, -NO2, =0, -CN, Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, areeach optionally substituted with one or more substituents independently selected from R7b.

[0096] In some embodiments, for a compound or salt of Formula (I), or Formula (I-A) R2is selected from: Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8b, -N(R8b)2, -C(O)R8b, - C(O)N(R8b)2, -N(R8b)C(O)R8b-C(O)OR8b, -OC(O)R8b, -S(O)2R8b, -NO2, =0, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7b.

[0097] In some embodiments, for a compound or salt of Formula (I), or Formula (I-A) R2together with R3form a C3-12 carbocycle, or 3- to 12-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8b, - N(R8b)2, -C(O)R8b, -C(O)N(R8b)2, =0, -CN, Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 6-membered heterocycle, wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 6-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7b.

[0098] In some embodiments, for a compound or salt of Formula (I), or Formula (I-A) R2is selected from: C3-6 carbocycle, and 3- to 6-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8b, - N(R8b)2, -C(O)R8b, -C(O)N(R8b)2, -N(R8b)C(O)R8b-C(O)OR8b, -OC(O)R8b, -S(O)2R8b, -NO2, =0, -CN, -N3, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, R2is selected from: phenyl, pyridyl, pyrimidyl, pyridazinyl, pyrimidinyl, and pyrazinyl, wherein each phenyl, pyridyl, pyrimidyl, pyridazinyl, pyrimidinyl, and pyrazinyl is optionally substituted with one or more substituents independently selected from halogen, -CN, and C1-6 alkyl, wherein C1-6 alkyl is optionally substituted with one or more R8b. In some embodiments, R2is selected from: phenyl, pyridyl, and pyrimidinyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, and C1-6 alkyl, wherein C1-6 alkyl is optionally substituted with one or more R8b. In some embodiments, R2is selected from: phenyl, pyridyl, and pyrimidinyl, each of which is optionally substituted with one or more substituents independently selected from fluoro and -CN. In some embodiments for a compound or salt of Formula (I), or Formula (I-A) R2is selected from:is selected from: hydrogen; and Ci-6 alkyl optionally substituted with one or more substituents independently selected from R7c. In some embodiments, R3is selected from hydrogen, methyl, ethyl, w-propyl, and isopropyl. In some embodiments, R3is hydrogen.

[0099] In some embodiments, for a compound or salt of Formula (I), or Formula (I- A), R2together with R3form a C3-10 carbocycle, or 3- to 15-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8a, -SR8a, - N(R8a)2, -C(O)R8a, -C(O)N(R8a)2, -N(R8a)C(O)R8a, -N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, - N(R8a)C(O)OR8a, -C(O)OR8a, -OC(O)R8a, -S(O)R8a, -S(O)2R8a, -NO2, =0-, =S, =N(R8a), -CN, Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7b. In some embodiments, R2together with R3form a C3-10 carbocycle, or 3- to 15-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8a, -SR8a, -N(R8a)2, - -NO2, =0-, -CN, Ci-6alkyl, C2.6alkenyl, C2.6alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7b. In some embodiments, R2together with R3form a C3- 10 cycloalkyl, or 3- to 15-membered heterocycloalkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8a, -SR8a, -N(R8a)2, -C(O)R8a, -C(O)N(R8a)2, -N(R8a)C(O)R8a, -N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, -N(R8a)C(O)OR8a, -C(O)OR8a, -OC(O)R8a, -S(O)R8a, -S(O)2R8a, -N02, =0- =S, =N(R8a), -CN, Ci-6alkyl, C2.6alkenyl, C2.6alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7b. In some embodiments, R2together with R3form an optionally substituted 3- to 15-membered heterocycle. In some embodiments, R2together with R3form an optionally substituted bridged 3- to 15-membered heterocycle. In some embodiments, the carbocycle or heterocycle formed from R2together with R3is bridged. In some embodiments, the carbocycle or heterocycle formed from R2together with R3is fused. In some embodiments, the carbocycle or heterocycle formed from R2together with R3is fused bridged. In some embodiments, R2together with R3form a heterocycle optionally substituted with one or more substituents independently selected from: halogen, -CN, -N02, -OH, -0(Ci-6 alkyl), -0(Ci-6 haloalkyl), -SH, - S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, C1-6 alkyl, and C1-6 haloalkyl. In some embodiments, R2together with R3form a heterocycle optionally substituted with one or more substituents independently selected from: -CN, -F, -Cl, -OH, -0(CH , -0(CF3), -NH2, -NH(CH , - N(CH3)2, -SH, -S(CH3), -CH3, and -CF3.

[0100] In some embodiments, for a compound or salt of Formula (I- A), or Formula (I), R2together with R3form a heterocycle selected from:that is optionally substituted (e.g., optionally substituted with one or more substituents independently selected from: halogen, -CN, -NO2, -OH, - O(Ci-6alkyl), -O(Ci-6haloalkyl), -SH, -S(Ci-6alkyl), -NH2, -NH(CI-6alkyl), -N(CI-6alkyl)2, Ci-6alkyl, and Ci-6 haloalkyl; or optionally substituted with one or more substituents independently selected from: -CN, -F, -Cl, -OH, -O(CH3), -O(CF3), -NH2, -NH(CH3), -N(CH3)2, -SH, -S(CH3), - CH3, and -CF3). In some embodiments, for a compound or salt of Formula (I), or Formula (I-A), R4is selected from: halogen, -OR8d, -SR8d, -N(R8d)2, -NO2, and -CN;Ci alkyl, C2alkyl, C3 alkyl, C4 alkyl, C5 alkyl, and Ce alkyl, wherein each Ci alkyl, C2alkyl, C3 alkyl, C4 alkyl, C5 alkyl, and Ce alkyl is optionally substituted with one or more substituents independently selected from R7d; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from R7d; orR4and R4atogether form a C4-10 carbocycle, or 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, or 3- to 10-membered heterocycle, is optionally substituted with one or more substituents independently selected from R7e.

[0101] In some embodiments, for a compound or salt of Formula (I), or Formula (I- A), R4is selected from: halogen, -OR8d, -SR8d, -N(R8d)2, -NO2, and -CN;C3-6 alkyl optionally substituted with one or more substituents independently selected from R7d; andC1-6 alkyl substituted with one or more substituents independently selected from halogen, -OR8d, -N(R8d)2, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7d; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from R7d; orR4and R4atogether form a C4-10 carbocycle, or 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, or 3- to 10-membered heterocycle, is optionally substituted with one or more substituents independently selected from R7e.

[0102] In some embodiments, for a compound or salt of Formula (I) or Formula (I-A), R4is selected from halogen, -OR8d, -SR8d, -N(R8d)2, -NO2, and -CN. In some embodiments, R4is -OR8d. In some embodiments, R4is -N(R8d)2.In some embodiments, for a compound or salt of Formula (I), or Formula (I-A), R4is selected from: C4-6 alkyl optionally substituted with one or more substituents independently selected from R7d. In some embodiments, R4is C4 alkyl. In some embodiments, R4is C5 alkyl. In some embodiments, R4is Ce alkyl. In some embodiments, R4is selected from: / / -butyl, ec-butyl, and isobutyl. In some embodiments, R4is isobutyl.

[0103] In some embodiments, for a compound or salt of Formula (I), or Formula (I-A), R4is selected from: C1-6 alkyl substituted with one or more substituents independently selected from C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R4is selected from C1-6 alkyl substituted with phenyl, pyridyl, pyrimidyl, pyridazinyl, pyrimidinyl, pyrazinyl, and [l.l.l]bicyclopentyl, wherein each phenyl, pyridyl, pyrimidyl, pyridazinyl, pyrimidinyl, pyrazinyl, and [l.l. l]bicyclopentyl is optionally substituted (e.g., with one or more substituents independently selected from halogen, -CN, and C1-6 alkyl). In some embodiments, R4is selected from C1-6 alkyl substituted with phenyl, pyridyl, pyrimidyl, pyridazinyl, pyrimidinyl, and pyrazinyl, wherein each phenyl, pyridyl, pyrimidyl, pyridazinyl, pyrimidinyl, and pyrazinyl is optionally substituted withone or more substituents independently selected from halogen, -CN, and C1-6 alkyl. In some embodiments, R4is selected from C1-6 alkyl substituted with phenyl.

[0104] In some embodiments, for a compound or salt of Formula (I), or Formula (I-A), R4is selected from: propyl, isopropyl, / / -butyl, sec-butyl, zso-butyl, tert-butyl, benzyl,embodiments, for a compound or salt of Formula (I), or Formula (I-A), R4is selected from: propyl, isopropyl, / / -butyl, sec-butyl, zso-butyl, tert-butyl, benzyl,some embodiments, R4is selected from: propyl, isopropyl, / / -butyl, sec-butyl, zso-butyl, and tertbutyl. In some embodiments, R4is zso-butyl. In some embodiments, R4is benzyl. In someembodiments, R4is. In some embodiments, R4is. In some embodiments, R4is, some embodiments,embodiments,some embodiments,embodiments, R4is not -CF3. In some embodiments, R4is not -CFRIn some embodiments, for a compound or salt of Formula (I), or Formula (I-A), R4ais selected from: hydrogen; halogen, -OR8e, -N(R8e)2, and -CN; andCi alkyl, C2 alkyl, C3 alkyl, C4 alkyl, C5 alkyl, and Ce alkyl, wherein each Ci alkyl, C2 alkyl, C3 alkyl, C4 alkyl, C5 alkyl, and Ce alkyl is optionally substituted with one or more substituents independently selected from halogen, -OR8e, -N(R8e)2, and -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7e.or R4and R4atogether form a C4-10 carbocycle, or 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, or 3- to 10-membered heterocycle, is optionally substituted with one or more substituents independently selected from R7e.

[0105] In some embodiments, R4ais selected from: CH2F, -CHF2, and C2-6 alkyl optionally substituted with one or more -F. In some embodiments, R4ais not -CF3, In some embodiments, R4ais not -CH3.

[0106] In some embodiments, for a compound or salt of Formula (I), or Formula (I-A) R4ais selected from: hydrogen, halogen, -OR8e, -N(R8e)2, and -CN; andC1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR8e, -N(R8e)2, and -CN, C3-10 carbocycle, and 3- to 10- membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7e. or R4and R4atogether form a C4-10 carbocycle, or 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, or 3- to 10-membered heterocycle, is optionally substituted with one or more substituents independently selected from R7e.

[0107] In some embodiments, for a compound or salt of Formula (I-A), or Formula (I), R4ais hydrogen, fluoro, -OH, -CN, or C1-6 alkyl. In some embodiments, R4ais hydrogen. In some embodiments, for a compound or salt of Formula (I), or Formula (I-A) R4and R4atogether form a C4-6 carbocycle, or 3- to 6-membered heterocycle, wherein the C3-6 carbocycle, or 3- to 6-membered heterocycle, is optionally substituted with one or more substituents independently selected from R7e. In some embodiments, R4and R4atogether form a C4 carbocycle optionally substituted. In some embodiments, R4and R4atogether form a C5 carbocycle optionally substituted. In some embodiments, R4and R4atogether form a Ce carbocycle optionally substituted. In some embodiments, for a compound or salt of Formula (I), Formula (I-A) R5is selected from: hydrogen, halogen, -OR8f, -N(R8f)2, C1-6 alkyl, C3-10 carbocycle, and 3- to 10- membered heterocycle, wherein the C1-6 alkyl, C3-10 carbocycle, and 3- to 10- membered heterocycle are each optionally substituted with one or more substituents independently selected from R7f. In some embodiments, R5is selected from: hydrogen, halogen, -OR8f, C1-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R5is selected from: hydrogen, halogen, C1-6 alkyl, C3-10 carbocycle, and 3- to 10- membered heterocycle. In some embodiments, R5is selected from: methyl, ethyl, n- propyl, and isopropyl. In some embodiments, R5is selected from: -OH and -O(Ci-6alkyl). In some embodiments, R5is -OH. In some embodiments, R5is -O(Ci-6 alkyl). In some embodiments, R5is -OCH3. In some embodiments, R5is hydrogen. In some embodiments, R5is halogen. In some embodiments, R5is -F, or -Cl. In some embodiments, R5is -F. In some embodiments, for a compound or salt of Formula (I) or Formula (I-A), R6is selected from: hydrogen; and C1-6 alkyl optionally substituted with one or more substituents independently selected from R7g. In some embodiments, R6is C1-6 alkyl. In some embodiments, R6is C1-6 alkyl substituted with one or more substituents selected from: -F, -Cl, -Br, -I, -CN, -OH, -NO2, -O-C1-6 alkyl, -N(CI-6 alkyl)2, and -NH(CI-6 alkyl). In some embodiments, R6is selected from: hydrogen, methyl, ethyl, w-propyl, and isopropyl. In some embodiments, R6is hydrogen. In some embodiments, for a compound or salt of Formula (I) or Formula (I-A), each R7is independently selected from: hydrogen, -F, -Cl, -Br, -I, -CN, -OH, -NO2, -O-C1-6 alkyl, - N(CI-6 alkyl)2, -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, -CN, -OH, =0, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, -CN, -OH, =0, =S, -O-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R7is independently selected from halogen, -CN, - N02, -OH, -O(Ci-6alkyl), -O(Ci-6haloalkyl), -SH, -S(Ci-6alkyl), -NH2, -NH(CI-6alkyl), -N(CI-6 alkyl)2, C1-6 alkyl, C1-6 haloalkyl, C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, each R7is independently selected from halogen, - CN, -NO2, -OH, -O(Ci-6alkyl), -O(Ci-6haloalkyl), -SH, -S(Ci-6alkyl), -NH2, -NH(CI-6alkyl), -N(CI-6 alkyl)2, C1-6 alkyl, and C1-6 haloalkyl. In some embodiments, each R7is independently selected from -F, -Cl, -CN, -NO2, -OH, -0(Ci-6 alkyl), -0(Ci-6 haloalkyl), -SH, -S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), and -N(CI-6 alkyl)2. In some embodiments, each R7is independently selected from -CN, -F, -Cl, -OH, -0(CH3), -0(CF3), -NH2, - NH(CH3), -N(CH3)2, -SH, -S(CH3), -CH3, and -CF3.

[0108] In some embodiments, for a compound or salt of Formula (I) or Formula (I-A), each R7ais independently selected from: hydrogen, -F, -Cl, -Br, -I, -CN, -OH, -NO2, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, -CN, -OH, =0, -O-Ci-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10- membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, - CN, -OH, =0, =S, -O-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R7ais independently selected from halogen, -CN, -NO2, -OH, -0(Ci-6 alkyl), - 0(Ci-6 haloalkyl), -SH, -S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, C1-6 alkyl, C1-6 haloalkyl, C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, each R7ais independently selected from halogen, -CN, -NO2, -OH, -0(Ci-6 alkyl), -0(Ci-6 haloalkyl), -SH, - S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, C1-6 alkyl, and C1-6 haloalkyl. In some embodiments, each R7ais independently selected from -F, -Cl, -CN, -NO2, -OH, -0(Ci-6 alkyl), - 0(Ci-6 haloalkyl), -SH, -S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), and -N(CI-6 alkyl)2. In some embodiments, each R7ais independently selected from -CN, -F, -Cl, -OH, -0(CH3), -0(CF3), -NH2, -NH(CH3), -N(CH3)2, -SH, -S(CH3), -CH3, and -CF3.

[0109] In some embodiments, for a compound or salt of Formula (I) or Formula (I-A), each R7bis independently selected from: hydrogen, -F, -Cl, -Br, -I, -CN, -OH, -NO2, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, - Br, -I, -CN, -OH, =0, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10- membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, - CN, -OH, =0, =S, -O-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-6 haloalkyl. In some embodiments, each R7bis independently selected from halogen, -CN, -NO2, -OH, -0(Ci-6 alkyl), - 0(Ci-6 haloalkyl), -SH, -S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, Ci-6 alkyl, Ci-6 haloalkyl, C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, each R7bis independently selected from halogen, -CN, -NO2, -OH, -0(Ci-6 alkyl), -0(Ci-6 haloalkyl), -SH, - S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, Ci-6 alkyl, and Ci-6 haloalkyl. In some embodiments, each R7bis independently selected from -F, -Cl, -CN, -NO2, -OH, -0(Ci-6 alkyl), - 0(Ci-6 haloalkyl), -SH, -S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), and -N(CI-6 alkyl)2. In some embodiments, each R7bis independently selected from -CN, -F, -Cl, -OH, -0(CH , -0(CF3), -NH2, -NH(CH3), -N(CH3)2, -SH, -S(CH3), -CH3, and -CF3.

[0110] In some embodiments, for a compound or salt of Formula (I) or Formula (I-A), each R7cis independently selected from: hydrogen, -F, -Cl, -Br, -I, -CN, -OH, -NO2, -O-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl); and Ci-6 alkyl, C2-6 alkenyl, C 2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, - Br, -I, -CN, -OH, =0, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10- membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, - CN, -OH, =0, =S, -O-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R7cis independently selected from halogen, -CN, -NO2, -OH, -0(Ci-6 alkyl), - 0(Ci-6 haloalkyl), -SH, -S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, C1-6 alkyl, C1-6 haloalkyl, C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, each R7cis independently selected from halogen, -CN, -NO2, -OH, -0(Ci-6 alkyl), -0(Ci-6 haloalkyl), -SH, - S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, C1-6 alkyl, and C1-6 haloalkyl. In some embodiments, each R7cis independently selected from -F, -Cl, -CN, -NO2, -OH, -0(Ci-6 alkyl), - 0(Ci-6 haloalkyl), -SH, -S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), and -N(CI-6 alkyl)2. In some embodiments, each R7cis independently selected from -CN, -F, -Cl, -OH, -0(CH3), -0(CF3), -NH2, -NH(CH3), -N(CH3)2, -SH, -S(CH3), -CH3, and -CF3.

[0111] In some embodiments, for a compound or salt of Formula (I) or Formula (I-A), each R7dis independently selected from: hydrogen, -F, -Cl, -Br, -I, -CN, -OH, -NO2, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, - Br, -I, -CN, -OH, =0, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10- membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, - CN, -OH, =0, =S, -O-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-6 haloalkyl. In some embodiments, each R7dis independently selected from halogen, -CN, -NO2, -OH, -0(Ci-6 alkyl), - 0(Ci-6 haloalkyl), -SH, -S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, Ci-6 alkyl, Ci-6 haloalkyl, C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, each R7dis independently selected from halogen, -CN, -NO2, -OH, -0(Ci-6 alkyl), -0(Ci-6 haloalkyl), -SH, - S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, Ci-6 alkyl, and Ci-6 haloalkyl. In some embodiments, each R7dis independently selected from -F, -Cl, -CN, -NO2, -OH, -0(Ci-6 alkyl), - 0(Ci-6 haloalkyl), -SH, -S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), and -N(CI-6 alkyl)2. In some embodiments, each R7dis independently selected from -CN, -F, -Cl, -OH, -0(CH , -0(CF3), -NH2, -NH(CH3), -N(CH3)2, -SH, -S(CH3), -CH3, and -CF3.

[0112] In some embodiments, for a compound or salt of Formula (I) or Formula (I-A), each R7eis independently selected from: hydrogen, -F, -Cl, -Br, -I, -CN, -OH, -NO2, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C 2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, - Br, -I, -CN, -OH, =0, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10- membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, - CN, -OH, =0, =S, -O-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R7eis independently selected from halogen, -CN, -NO2, -OH, -0(Ci-6 alkyl), - 0(Ci-6 haloalkyl), -SH, -S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, C1-6 alkyl, C1-6 haloalkyl, C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, each R7eis independently selected from halogen, -CN, -NO2, -OH, -0(Ci-6 alkyl), -0(Ci-6 haloalkyl), -SH, - S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, C1-6 alkyl, and C1-6 haloalkyl. In some embodiments, each R7eis independently selected from -F, -Cl, -CN, -NO2, -OH, -0(Ci-6 alkyl), - 0(Ci-6 haloalkyl), -SH, -S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), and -N(CI-6 alkyl)2. In some embodiments, each R7eis independently selected from -CN, -F, -Cl, -OH, -0(CH3), -0(CF3), -NH2, -NH(CH3), -N(CH3)2, -SH, -S(CH3), -CH3, and -CF3.

[0113] In some embodiments, for a compound or salt of Formula (I) or Formula (I-A), each R7fis independently selected from: hydrogen, -F, -Cl, -Br, -I, -CN, -OH, -NO2, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, - Br, -I, -CN, -OH, =0, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10- membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, - CN, -OH, =0, =S, -O-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-6 haloalkyl. In some embodiments, each R7fis independently selected from halogen, -CN, -NO2, -OH, -0(Ci-6 alkyl), - 0(Ci-6 haloalkyl), -SH, -S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, Ci-6 alkyl, Ci-6 haloalkyl, C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, each R7fis independently selected from halogen, -CN, -NO2, -OH, -0(Ci-6 alkyl), -0(Ci-6 haloalkyl), -SH, - S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, Ci-6 alkyl, and Ci-6 haloalkyl. In some embodiments, each R7fis independently selected from -F, -Cl, -CN, -NO2, -OH, -0(Ci-6 alkyl), - 0(Ci-6 haloalkyl), -SH, -S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), and -N(CI-6 alkyl)2. In someembodiments, each R7fis independently selected from -CN, -F, -Cl, -OH, -O(CH3), -O(CF3), -NH2, -NH(CH3), -N(CH3)2, -SH, -S(CH3), -CH3, and -CF3.

[0114] In some embodiments, for a compound or salt of Formula (I) or Formula (I-A), each R7gis independently selected from: hydrogen, -F, -Cl, -Br, -I, -CN, -OH, -NO2, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C 2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, - Br, -I, -CN, -OH, =0, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10- membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, - CN, -OH, =0, =S, -O-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R7gis independently selected from halogen, -CN, -N02, -OH, -0(Ci-6 alkyl), - 0(Ci-6 haloalkyl), -SH, -S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, C1-6 alkyl, C1-6 haloalkyl, C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, each R7gis independently selected from halogen, -CN, -N02, -OH, -0(Ci-6 alkyl), -0(Ci-6 haloalkyl), -SH, - S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, C1-6 alkyl, and C1-6 haloalkyl. In some embodiments, each R7gis independently selected from -F, -Cl, -CN, -N02, -OH, -0(Ci-6 alkyl), - 0(Ci-6 haloalkyl), -SH, -S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), and -N(CI-6 alkyl)2. In some embodiments, each R7gis independently selected from -CN, -F, -Cl, -OH, -0(CH , -0(CF3), -NH2, -NH(CH3), -N(CH3)2, -SH, -S(CH3), -CH3, and -CF3.

[0115] In some embodiments, for a compound or salt of Formula (I) or Formula (I-A), each R8is independently selected from: hydrogen, -F, -Cl, -Br, -I, -CN, -OH, -NO2, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, - Br, -I, -CN, -OH, =0, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10- membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, - CN, -OH, =0, =S, -O-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-6 haloalkyl. In some embodiments, each R8is independently selected from: hydrogen, halogen, -CN, -OH, -SH, -N02, - NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, and -NH(CI-6 alkyl); and Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-memberedheterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R8is independently selected from: hydrogen; C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R8is independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R8is independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, - CN, -NO2, -OH, -O(Ci-6alkyl), -O(Ci-6haloalkyl), -SH, -S(Ci-6alkyl), -NH2, -NH(CI-6alkyl), - N(CI-6 alkyl)2, C3-10 carbocycle and 3-10 membered heterocycle; and C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -N02, -OH, -0(Ci-6 alkyl), -0(Ci-6 haloalkyl), -SH, - S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, C1-6 alkyl, and C1-6 haloalkyl. In some embodiments, each R8is independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from -CN, -F, -Cl, -OH, -0(CH , -0(CF3), - NH2, -NH(CH3), -N(CH3)2, -SH, -S(CH3), -CH3, and -CF3; and C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -CN, -F, -Cl, -OH, -0(CH3), -O(CF3), -NH2, -NH(CH3), -N(CH3)2, - SH, -S(CH3), -CH3, and -CF3. In some embodiments, each R8is independently selected from: hydrogen; C1-6 alkyl; C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, each R8is independently selected from: hydrogen; C1-6 alkyl; and C1-6haloalkyl (e.g., fluoroalkyl). In some embodiments, each R8is independently selected from: hydrogen; and Ci-6 alkyl. In some embodiments, each R8is independently selected from: hydrogen; and Ci-6 alkyl; and C3-10 carbocycle. In some embodiments, each R8is independently selected from: hydrogen; and C1-6 alkyl; and C3-10 carbocycle, wherein the C3-10 carbocycle is [l.l. l]bicyclopentyl or cyclobutyl. In some embodiments, each R8is independently selected from: hydrogen; and C1-5 alkyl. In some embodiments, each R8is independently selected from: hydrogen; and C1-4 alkyl. In some embodiments, each R8is independently selected from: hydrogen; and C1-3 alkyl. In some embodiments, each R8is independently selected from: hydrogen; and C1-2 alkyl. In some embodiments, each R8is independently selected from: hydrogen; and Ci alkyl. In some embodiments, each R8is independently selected from: hydrogen. In some embodiments, each R8is independently selected from: Ci alkyl.

[0116] In some embodiments, for a compound or salt of Formula (I) or Formula (I-A), each R8ais independently selected from: hydrogen, -F, -Cl, -Br, -I, -CN, -OH, -NO2, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C 2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, - Br, -I, -CN, -OH, =0, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10- membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, - CN, -OH, =0, =S, -O-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R8ais independently selected from: hydrogen, halogen, -CN, -OH, -SH, -NO2, - NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, and -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R8ais independently selected from: hydrogen; C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionallysubstituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R8ais independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R8ais independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, - CN, -NO2, -OH, -O(Ci-6alkyl), -O(Ci-6haloalkyl), -SH, -S(Ci-6alkyl), -NH2, -NH(CI-6alkyl), - N(CI-6 alkyl)2, C3-10 carbocycle and 3-10 membered heterocycle; and C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -N02, -OH, -0(Ci-6 alkyl), -0(Ci-6 haloalkyl), -SH, - S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, C1-6 alkyl, and C1-6 haloalkyl. In some embodiments, each R8ais independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from -CN, -F, -Cl, -OH, -0(CH , -0(CF3), - NH2, -NH(CH3), -N(CH3)2, -SH, -S(CH3), -CH3, and -CF3; and C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -CN, -F, -Cl, -OH, -0(CH3), -O(CF3), -NH2, -NH(CH3), -N(CH3)2, - SH, -S(CH3), -CH3, and -CF3. In some embodiments, each R8ais independently selected from: hydrogen; C1-6 alkyl; C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, each R8ais independently selected from: hydrogen; C1-6 alkyl; and C1-6 haloalkyl (e.g., fluoroalkyl). In some embodiments, each R8ais independently selected from: hydrogen; and C1-6 alkyl. In some embodiments, each R8ais independently selected from: hydrogen; and C1-6 alkyl; and C3-10 carbocycle. In some embodiments, each R8ais independently selected from: hydrogen; and C1-6 alkyl; and C3-10 carbocycle, wherein the C3-10 carbocycle is [l. l.l]bicyclopentyl or cyclobutyl. In some embodiments, each R8ais independently selected from: hydrogen; and C1-5 alkyl. In some embodiments, each R8ais independently selected from: hydrogen; and C1-4 alkyl. In some embodiments, each R8ais independently selected from: hydrogen; and C1-3 alkyl. In some embodiments, each R8ais independently selected from: hydrogen; and C1-2 alkyl. In some embodiments, each R8ais independently selected from: hydrogen; and Ci alkyl. In someembodiments, each R8ais independently selected from: hydrogen. In some embodiments, each R8ais independently selected from: Ci alkyl.

[0117] In some embodiments, for a compound or salt of Formula (I) or Formula (I-A), each R8bis independently selected from: hydrogen, -F, -Cl, -Br, -I, -CN, -OH, -NO2, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C 2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, - Br, -I, -CN, -OH, =0, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10- membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, - CN, -OH, =0, =S, -O-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. . In some embodiments, each R8bis independently selected from: hydrogen, halogen, -CN, -OH, -SH, -NO2, - NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, and -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R8bis independently selected from: hydrogen; C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R8bis independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), Ci-6 alkyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R8bis independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, - CN, -NO2, -OH, -O(Ci-6 alkyl), -O(Ci-6haloalkyl), -SH, -S(Ci-6alkyl), -NH2, -NH(CI-6alkyl), - N(CI-6 alkyl)2, C3-10 carbocycle and 3-10 membered heterocycle; and C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -O(Ci-6 alkyl), -O(Ci-6 haloalkyl), -SH, - S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, C1-6 alkyl, and C1-6 haloalkyl. In some embodiments, each R8bis independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from -CN, -F, -Cl, -OH, -O(CH , -O(CF3), - NH2, -NH(CH3), -N(CH3)2, -SH, -S(CH3), -CH3, and -CF3; and C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -CN, -F, -Cl, -OH, -O(CH3), -O(CF3), -NH2, -NH(CH3), -N(CH3)2, - SH, -S(CH3), -CH3, and -CF3. In some embodiments, each R8bis independently selected from: hydrogen; C1-6 alkyl; C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, each R8bis independently selected from: hydrogen; C1-6 alkyl; and C1-6 haloalkyl (e.g., fluoroalkyl). In some embodiments, each R8bis independently selected from: hydrogen; and C1-6 alkyl. In some embodiments, each R8bis independently selected from: hydrogen; and C1-6 alkyl; and C3-10 carbocycle. In some embodiments, each R8bis independently selected from: hydrogen; and C1-6 alkyl; and C3-10 carbocycle, wherein the C3-10 carbocycle is [l.l. l]bicyclopentyl or cyclobutyl. In some embodiments, each R8bis independently selected from: hydrogen; and C1-5 alkyl. In some embodiments, each R8bis independently selected from: hydrogen; and C1-4 alkyl. In some embodiments, each R8bis independently selected from: hydrogen; and C1-3 alkyl. In some embodiments, each R8bis independently selected from: hydrogen; and C1-2 alkyl. In some embodiments, each R8bis independently selected from: hydrogen; and Ci alkyl. In some embodiments, each R8bis independently selected from: hydrogen. In some embodiments, each R8bis independently selected from: Ci alkyl.

[0118] In some embodiments, for a compound or salt of Formula (I) or Formula (I-A), each R8cis independently selected from: hydrogen, -F, -Cl, -Br, -I, -CN, -OH, -NO2, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C2-e alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, - Br, -I, -CN, -OH, =0, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10- membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, -CN, -OH, =0, =S, -O-Ci-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R8cis independently selected from: hydrogen, halogen, -CN, -OH, -SH, -NO2, - NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, and -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R8cis independently selected from: hydrogen; C1-6 alkyl, C2- 6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O- C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R8cis independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R8cis independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, - CN, -NO2, -OH, -O(Ci-6alkyl), -O(Ci-6haloalkyl), -SH, -S(Ci-6alkyl), -NH2, -NH(CI-6alkyl), - N(CI-6 alkyl)2, C3-10 carbocycle and 3-10 membered heterocycle; and C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -0(Ci-6 alkyl), -0(Ci-6 haloalkyl), -SH, - S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, C1-6 alkyl, and C1-6 haloalkyl. In some embodiments, each R8cis independently selected from: hydrogen; C1-6 alkyl, optionally substitutedwith one or more substituents independently selected from -CN, -F, -Cl, -OH, -O(CH3), -O(CF3), -NH2, -NH(CH3), -N(CH3)2, -SH, -S(CH3), -CH3, and -CF3; and C3-io carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -CN, -F, -Cl, -OH, -O(CH3), -O(CF3), -NH2, -NH(CH3), -N(CH3)2, - SH, -S(CH3), -CH3, and -CF3. In some embodiments, each R8cis independently selected from: hydrogen; C1-6 alkyl; C1-6 haloalkyl; and C3-io carbocycle and 3- to 10-membered heterocycle. In some embodiments, each R8cis independently selected from: hydrogen; C1-6 alkyl; and C1-6 haloalkyl (e.g., fluoroalkyl). In some embodiments, each R8cis independently selected from: hydrogen; and C1-6 alkyl. In some embodiments, each R8cis independently selected from: hydrogen; and C1-6 alkyl; and C3-io carbocycle. In some embodiments, each R8cis independently selected from: hydrogen; and Ci-6 alkyl; and C3-io carbocycle, wherein the C3-io carbocycle is [l.l. l]bicyclopentyl or cyclobutyl. In some embodiments, each R8cis independently selected from: hydrogen; and C1-5 alkyl. In some embodiments, each R8cis independently selected from hydrogen; and C1-4 alkyl. In some embodiments, each R8cis independently selected from hydrogen; and Ci-3alkyl. In some embodiments, each R8cis independently selected from hydrogen; and C1-2 alkyl. In some embodiments, each R8cis independently selected from hydrogen; and Ci alkyl. In some embodiments, each R8cis independently selected from: hydrogen.In some embodiments, each R8cis independently selected from: Ci alkyl.

[0119] In some embodiments, for a compound or salt of Formula (I) or Formula (I-A), each R8dis independently selected from: hydrogen, -F, -Cl, -Br, -I, -CN, -OH, -NO2, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-io carbocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, - Br, -I, -CN, -OH, =0, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-io carbocycle, 3- to 10- membered heterocycle; and C3-io carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, - CN, -OH, =0, =S, -O-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6alkyl, C2.6alkenyl, C2-6 alkynyl, C3-io carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R8dis independently selected from: hydrogen, halogen, -CN, -OH, -SH, -NO2, - NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, and -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-io carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-io carbocycle, 3- to 10-membered heterocycle; and C3-io carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -N02, -NH2, =0, =S, -O-Ci-6 alkyl, -S-Ci-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R8dis independently selected from: hydrogen; C1-6 alkyl, C2. 6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -N02, -NH2, =0, =S, -O- C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R8dis independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-Ci-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R8dis independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, - CN, -N02, -OH, -O(CI-6alkyl), -O(Ci-6haloalkyl), -SH, -S(Ci-6alkyl), -NH2, -NH(CI-6alkyl), - N(CI-6 alkyl)2, C3-10 carbocycle and 3-10 membered heterocycle; and C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -N02, -OH, -0(Ci-6 alkyl), -0(Ci-6 haloalkyl), -SH, - S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, C1-6 alkyl, and C1-6 haloalkyl. In some embodiments, each R8dis independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from -CN, -F, -Cl, -OH, -0(CH , -0(CF3), - NH2, -NH(CH3), -N(CH3)2, -SH, -S(CH3), -CH3, and -CF3; and C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -CN, -F, -Cl, -OH, -0(CH3), -O(CF3), -NH2, -NH(CH3), -N(CH3)2, - SH, -S(CH3), -CH3, and -CF3. In some embodiments, each R8dis independently selected from: hydrogen; C1-6 alkyl; C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, each R8dis independently selected from: hydrogen; C1-6 alkyl; and C1-6 haloalkyl (e.g., fluoroalkyl). In some embodiments, each R8dis independently selected from: hydrogen; and C1-6 alkyl. In some embodiments, each R8dis independently selected from:hydrogen; and C1-6 alkyl; and C3-10 carbocycle. In some embodiments, each R8dis independently selected from: hydrogen; and Ci-6 alkyl; and C3-10 carbocycle, wherein the C3-10 carbocycle is[l.l. l]bicyclopentyl or cyclobutyl. In some embodiments, each R8dis independently selected from: hydrogen; and C1-5 alkyl. In some embodiments, each R8dis independently selected from hydrogen; and C1-4 alkyl. In some embodiments, each R8dis independently selected from hydrogen; and C1-3 alkyl. In some embodiments, each R8dis independently selected from hydrogen; and C1-2 alkyl. In some embodiments, each R8dis independently selected from hydrogen; and Ci alkyl. In some embodiments, each R8dis independently selected from: hydrogen.In some embodiments, each R8dis independently selected from: Ci alkyl.

[0120] In some embodiments, for a compound or salt of Formula (I) or Formula (I-A), each R8eis independently selected from: hydrogen, -F, -Cl, -Br, -I, -CN, -OH, -NO2, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, - Br, -I, -CN, -OH, =0, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10- membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, - CN, -OH, =0, =S, -O-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R8eis independently selected from: hydrogen, halogen, -CN, -OH, -SH, -NO2, - NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, and -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R8eis independently selected from: hydrogen; C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O- C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl),Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R8eis independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R8eis independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, - CN, -NO2, -OH, -O(Ci-6alkyl), -O(Ci-6haloalkyl), -SH, -S(Ci-6alkyl), -NH2, -NH(CI-6alkyl), - N(CI-6 alkyl)2, C3-10 carbocycle and 3-10 membered heterocycle; and C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -0(Ci-6 alkyl), -0(Ci-6 haloalkyl), -SH, - S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, C1-6 alkyl, and C1-6 haloalkyl. In some embodiments, each R8eis independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from -CN, -F, -Cl, -OH, -0(CH , -0(CF3), - NH2, -NH(CH3), -N(CH3)2, -SH, -S(CH3), -CH3, and -CF3; and C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -CN, -F, -Cl, -OH, -0(CH3), -O(CF3), -NH2, -NH(CH3), -N(CH3)2, - SH, -S(CH3), -CH3, and -CF3. In some embodiments, each R8eis independently selected from: hydrogen; C1-6 alkyl; C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, each R8eis independently selected from: hydrogen; C1-6 alkyl; and C1-6 haloalkyl (e.g., fluoroalkyl). In some embodiments, each R8eis independently selected from: hydrogen; and C1-6 alkyl. In some embodiments, each R8eis independently selected from: hydrogen; and C1-6 alkyl; and C3-10 carbocycle. In some embodiments, each R8eis independently selected from: hydrogen; and C1-6 alkyl; and C3-10 carbocycle, wherein the C3-10 carbocycle is [1.1. l]bicyclopentyl or cyclobutyl. In some embodiments, each R8eis independently selected from: hydrogen; and C1-5 alkyl. In some embodiments, each R8eis independently selected from: hydrogen; and C1-4 alkyl. In some embodiments, each R8eis independently selected from: hydrogen; and C1-3 alkyl. In some embodiments, each R8eis independently selected from: hydrogen; and C1-2 alkyl. In some embodiments, each R8eis independently selected from: hydrogen; and Ci alkyl. In some embodiments, each R8eis independently selected from: hydrogen. In some embodiments, each R8eis independently selected from: Ci alkyl.

[0121] In some embodiments, for a compound or salt of Formula (I) or Formula (I-A), each R8fis independently selected from: hydrogen, -F, -Cl, -Br, -I, -CN, -OH, -NO2, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C 2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, - Br, -I, -CN, -OH, =0, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10- membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, - CN, -OH, =0, =S, -O-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R8fis independently selected from: hydrogen, halogen, -CN, -OH, -SH, -NO2, - NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, and -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R8fis independently selected from: hydrogen; C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O- C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R8fis independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R8fis independently selected from: hydrogen; C1-6alkyl, optionally substituted with one or more substituents independently selected from halogen, - CN, -NO2, -OH, -O(Ci-6alkyl), -O(Ci-6haloalkyl), -SH, -S(Ci-6alkyl), -NH2, -NH(CI-6alkyl), - N(CI-6 alkyl)2, C3-io carbocycle and 3-10 membered heterocycle; and C3-io carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -O(Ci-6 alkyl), -O(Ci-6 haloalkyl), -SH, - S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, C1-6 alkyl, and C1-6 haloalkyl. In some embodiments, each R8fis independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from -CN, -F, -Cl, -OH, -O(CH3), -O(CF3), - NH2, -NH(CH3), -N(CH3)2, -SH, -S(CH3), -CH3, and -CF3; and C3-io carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -CN, -F, -Cl, -OH, -O(CH3), -O(CF3), -NH2, -NH(CH3), -N(CH3)2, - SH, -S(CH3), -CH3, and -CF3. In some embodiments, each R8fis independently selected from: hydrogen; C1-6 alkyl; C1-6 haloalkyl; and C3-io carbocycle and 3- to 10-membered heterocycle. In some embodiments, each R8fis independently selected from: hydrogen; C1-6 alkyl; and C1-6 haloalkyl (e.g., fluoroalkyl). In some embodiments, each R8fis independently selected from: hydrogen; and C1-6 alkyl. In some embodiments, each R8fis independently selected from: hydrogen; and C1-6 alkyl; and C3-io carbocycle. In some embodiments, each R8fis independently selected from: hydrogen; and C1-6 alkyl; and C3-io carbocycle, wherein the C3-io carbocycle is [1.1. l]bicyclopentyl or cyclobutyl. In some embodiments, each R8fis independently selected from: hydrogen; and C1-5 alkyl. In some embodiments, each R8fis independently selected from: hydrogen; and C1-4 alkyl. In some embodiments, each R8fis independently selected from: hydrogen; and Ci-3alkyl. In some embodiments, each R8fis independently selected from: hydrogen; and C1-2 alkyl. In some embodiments, each R8fis independently selected from: hydrogen; and Ci alkyl. In some embodiments, each R8fis independently selected from: hydrogen. In some embodiments, each R8fis independently selected from: Ci alkyl.

[0122] In some embodiments, for a compound or salt of Formula (I) or Formula (I-A), each R8gis independently selected from: hydrogen, -F, -Cl, -Br, -I, -CN, -OH, -NO2, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C2-e alkynyl, and C3-io carbocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, - Br, -I, -CN, -OH, =0, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-io carbocycle, 3- to 10- membered heterocycle; and C3-io carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, - CN, -OH, =0, =S, -O-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-io carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In someembodiments, each R8gis independently selected from: hydrogen, halogen, -CN, -OH, -SH, -NO2, - NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, and -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R8gis independently selected from: hydrogen; C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O- C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R8gis independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R8gis independently selected from: hydrogen; Cn 6 alkyl, optionally substituted with one or more substituents independently selected from halogen, - CN, -NO2, -OH, -O(Ci-6alkyl), -O(Ci-6haloalkyl), -SH, -S(Ci-6alkyl), -NH2, -NH(CI-6alkyl), - N(CI-6 alkyl)2, C3-10 carbocycle and 3-10 membered heterocycle; and C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -0(Ci-6 alkyl), -0(Ci-6 haloalkyl), -SH, - S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, C1-6 alkyl, and C1-6 haloalkyl. In some embodiments, each R8gis independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from -CN, -F, -Cl, -OH, -0(CH , -O(CF3), -NH2, -NH(CH3), -N(CH3)2, -SH, -S(CH3), -CH3, and -CF3; and C3-10 carbocycle and 3- to10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -CN, -F, -Cl, -OH, -O(CH3), -O(CF3), -NH2, -NH(CH3), -N(CH3)2, - SH, -S(CH3), -CH3, and -CF3. In some embodiments, each R8gis independently selected from: hydrogen; Ci-6 alkyl; Ci-6 haloalkyl; and C3-io carbocycle and 3- to 10-membered heterocycle. In some embodiments, each R8gis independently selected from: hydrogen; Ci-6 alkyl; and Ci-6 haloalkyl (e.g., fluoroalkyl). In some embodiments, each R8gis independently selected from: hydrogen; and Ci-6 alkyl. In some embodiments, each R8gis independently selected from: hydrogen; and Ci-6 alkyl; and C3-io carbocycle. In some embodiments, each R8gis independently selected from: hydrogen; and Ci-6 alkyl; and C3-io carbocycle, wherein the C3-io carbocycle is [l.l. l]bicyclopentyl or cyclobutyl. In some embodiments, each R8gis independently selected from: hydrogen; and C1-5 alkyl. In some embodiments, each R8gis independently selected from: hydrogen; and C1-4 alkyl. In some embodiments, each R8gis independently selected from: hydrogen; and Ci-3alkyl. In some embodiments, each R8gis independently selected from: hydrogen; and Ci-2alkyl. In some embodiments, each R8gis independently selected from: hydrogen; and Ci alkyl. In some embodiments, each R8gis independently selected from: hydrogen. In some embodiments, each R8gis independently selected from: Ci alkyl.

[0123] In some embodiments, for a compound or salt of Formula (I) or Formula (I-A), the compound is selected from:

[0124] In some embodiments, for a compound or salt of Formula (I-A), or Formula (I), the compound is not:

[0125] In an aspect, the present disclosure provides a compound represented by Formula (II):or a salt thereof, wherein:X11, X12, X13, and X14are independently selected from C(R10) and N; each R10is independently selected from: hydrogen, halogen, -NO2, -CN, -N3, -OR18, -SR18, -N(R18)2, -C(O)R18, - C(O)N(R18)2, -N(R18)C(O)R18, -N(R18)C(O)N(R18)2, -OC(O)N(R18)2, - N(R18)C(O)OR18, -C(O)OR18, -OC(O)R18, -S(O)R18, and -S(O)2R18;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR18, -SR18, - N(R18)2, -C(O)R18, -C(O)N(R18)2, -N(R18)C(O)R18-C(O)OR18, -OC(O)R18, - N(R18)C(O)N(R18)2, -OC(O)N(R18)2, -N(R18)C(O)OR18, -S(O)R18, -S(O)2R18, -NO2, =0, =S, =N(R18), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3- 10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R17; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR18, - SR18, -N(R18)2, -C(O)R18, -C(O)N(R18)2, -N(R18)C(O)R18, -N(R18)C(O)N(R18)2, - OC(O)N(R18)2, -N(R18)C(O)OR18, -C(O)OR18, -OC(O)R18, -S(O)R18, -S(O)2R18, -NO2, =0, =S, =N(R18), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R17;R11is selected from: hydrogen;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R18a, -SR18a, -N(R18a)2, -C(O)R18a, -C(O)N(R18a)2, -N(R18a)C(O)R18a, -C(O)OR18a, -OC(O)R18a, - N(R18a)C(O)N(R18a)2, -OC(O)N(R18a)2, -N(R18a)C(O)OR18a, -S(O)R18a, -S(O)2R18a, -N02, =0, =S, =N(R18a), -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17a; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R18a, - SR18a, -N(R18a)2, -C(0)R18a, -C(O)N(R18a)2, -N(R18a)C(O)R18a, -N(R18a)C(O)N(R18a)2, - OC(O)N(R18a)2, -N(R18a)C(O)OR18a, -C(0)0R18a, -0C(0)R18a, -S(O)R18a, -S(O)2R18a, - N02, =0, =S, =N(R18a), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R17a; orR11together with R12form a C3-10 carbocycle, or 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R18a, -SR18a, -N(R18a)2, -C(0)R18a, -C(O)N(R18a)2, - N(R18a)C(O)R18a, -N(R18a)C(O)N(R18a)2, -OC(O)N(R18a)2, - N(R18a)C(O)OR18a, -C(0)0R18a, -0C(0)R18a, -S(O)R18a, -S(O)2R18a, -N02, =0 , =S, =N(R18a), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R17a;R12is selected from: hydrogen;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R18b, -SR18b, - N(R18b)2, -C(0)R18b, -C(O)N(R18b)2, -N(R18b)C(O)R18b-C(0)0R18b, -0C(0)R18b, - N(R18b)C(O)N(R18b)2, -OC(O)N(R18b)2, -N(R18b)C(O)OR18b, -S(O)R18b, -S(O)2R18b, - N02, =0, =S, =N(R18b), -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17b; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R18b, - SR18b, -N(R18b)2, -C(0)R18b, -C(O)N(R18b)2, -N(R18b)C(O)R18b-N(R18b)C(O)N(R18b)2, - OC(O)N(R18b)2, -N(R18b)C(O)OR18b, -C(0)0R18b, -0C(0)R18b, -S(O)R18b, -S(O)2R18b, - N02, =0, =S, =N(R18b), -CN, -N3, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, C3-10carbocycle and 3- to 10-membered heterocycle, wherein Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17b; orR12together with R13form a C3-10 carbocycle, or 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8a, -SR8a, -N(R8a)2, -C(O)R8a, -C(O)N(R8a)2, -N(R8a)C(O)R8a, -N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, -N(R8a)C(O)OR8a, -C(O)OR8a, -OC(O)R8a, - S(O)R8a, -S(O)2R8a, -NO2, =0-, =S, =N(R8a), -CN, Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein C1-6 alkyl, C2-6 alkenyl, C2- 6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17b;R13is selected from: hydrogen; andC1-6 alkyl optionally substituted with one or more substituents independently selected from R17c;R14is selected from: hydrogen; andC1-6 alkyl substituted with one or more substituents independently selected from halogen, -0R18d, -SR18d, -N(R18d)2, -NO2, and -CN, C3-10 carbocycle, and 3- to 10- membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17d; andR14ais selected from: hydrogen; andC1-6 alkyl substituted with one or more substituents independently selected from halogen, -0R18d, -SR18d, -N(R18d)2, -NO2, and -CN, C3-10 carbocycle, and 3- to 10- membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17d; and or R4and R4atogether form a C3-10 carbocycle, or 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, or 3- to 10-membered heterocycle, is optionally substituted with one or more substituents independently selected from R17d;R15is selected from:C4-6 alkyl, C3-10 heterocycloalkyl, and 4- to 10-membered heterocycle, wherein the C4-6 alkyl, C3-10 heterocycloalkyl, and 4- to 10- membered heterocycle are each optionally substituted with one or more substituents independently selected from R17e;R16is selected from: hydrogen; andC1-6 alkyl optionally substituted with one or more substituents independently selected from R17f; each R17, R17a, R17b, R17c, R17d, R17e, and R17fis independently selected from: hydrogen, halogen, -CN, -OH, -SH, -NO2, -NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, - N(CI-6 alkyl)2, and -NH(CI-6 alkyl); andC1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10- membered heterocycle, and Ci-e haloalkyl; each R18, R18a, R18b, R18c, and R18dis independently selected from: hydrogen, halogen, -CN, -OH, -SH, -NO2, -NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, - N(CI-6 alkyl)2, and -NH(CI-6 alkyl); andC1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10- membered heterocycle, and Ci-e haloalkyl.

[0126] In an aspect, the present disclosure provides a compound represented by Formula (II-A):or a salt thereof, wherein:X11, X12, X13, and X14are independently selected from C(R10), and N; wherein no more than two of X11, X12, X13, and X14are N; wherein no more than three of X11, X12, X13, and X14are C(H); each R10is independently selected from: hydrogen, halogen, -NO2, -CN, -N3, -OR18, -SR18, -N(R18)2, -C(O)R18, - C(O)N(R18)2, -N(R18)C(O)R18, -N(R18)C(O)N(R18)2, -OC(O)N(R18)2, - N(R18)C(O)OR18, -C(O)OR18, -OC(O)R18, -S(O)R18, and -S(O)2R18;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR18, -SR18, - N(R18)2, -C(O)R18, -C(O)N(R18)2, -N(R18)C(O)R18-C(O)OR18, -OC(O)R18, - N(R18)C(O)N(R18)2, -OC(O)N(R18)2, -N(R18)C(O)OR18, -S(O)R18, -S(O)2R18, -NO2, =0, =S, =N(R18), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3- 10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R17; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR18, - SR18, -N(R18)2, -C(0)R18, -C(O)N(R18)2, -N(R18)C(O)R18, -N(R18)C(O)N(R18)2, - OC(O)N(R18)2, -N(R18)C(O)OR18, -C(0)0R18, -0C(0)R18, -S(O)R18, -S(O)2R18, -NO2, =0, =S, =N(R18), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R17;R11is selected from: hydrogen;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R18a, -SR18a, - N(R18a)2, -C(0)R18a, -C(O)N(R18a)2, -N(R18a)C(O)R18a, -C(0)0R18a, -0C(0)R18a, - N(R18a)C(O)N(R18a)2, -OC(O)N(R18a)2, -N(R18a)C(O)OR18a, -S(O)R18a, -S(O)2R18a, -N02, =0, =S, =N(R18a), -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, whereinthe C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17a; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR18a, - SR18a, -N(R18a)2, -C(O)R18a, -C(O)N(R18a)2, -N(R18a)C(O)R18a, -N(R18a)C(O)N(R18a)2, - OC(O)N(R18a)2, -N(R18a)C(O)OR18a, -C(O)OR18a, -OC(O)R18a, -S(O)R18a, -S(O)2R18a, - NO2, =0, =S, =N(R18a), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R17a; orR11together with R12form a C3-10 carbocycle, or 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R18a, -SR18a, -N(R18a)2, -C(0)R18a, -C(O)N(R18a)2, - N(R18a)C(O)R18a, -N(R18a)C(O)N(R18a)2, -OC(O)N(R18a)2, - N(R18a)C(O)OR18a, -C(0)0R18a, -0C(0)R18a, -S(O)R18a, -S(O)2R18a, -N02, =0 , =S, =N(R18a), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R17a;R12is selected from:C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R18b, - SR18b, -N(R18b)2, -C(0)R18b, -C(O)N(R18b)2, -N(R18b)C(O)R18b-N(R18b)C(O)N(R18b)2, - OC(O)N(R18b)2, -N(R18b)C(O)OR18b, -C(0)0R18b, -0C(0)R18b, -S(O)R18b, -S(O)2R18b, - N02, =0, =S, =N(R18b), -CN, -N3, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17b; orR12together with R13form a 3- to 20-membered heterocycloalkyl or a 5-to 20- membered heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R18a, -SR18a, -N(R18a)2, -C(0)R18a, - C(O)N(R18a)2, -N(R18a)C(O)R18a, -N(R18a)C(O)N(R18a)2, -OC(O)N(R18a)2, - N(R18a)C(O)OR18a, -C(0)0R18a, -0C(0)R18a, -S(O)R18a, -S(O)2R18a, -N02, =0, =S, =N(R18a), -CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10- membered heterocycle, wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycleand 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R17b;R13is selected from: hydrogen; andCi-6 alkyl optionally substituted with one or more substituents independently selected from R17c;R14is selected from: hydrogen; andCi-6 alkyl substituted with one or more substituents independently selected from halogen, -OR18d, -SR18d, -N(R18d)2, -NO2, and -CN, C3-10 carbocycle, and 3- to 10- membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17d; andR14ais selected from: hydrogen, halogen, -OR18e, -SR18e, -N(R18e)2, -NO2, and -CN; andC1-6 alkyl substituted with one or more substituents independently selected from halogen, -OR18d, -SR18d, -N(R18d)2, -NO2, and -CN, C3-10 carbocycle, and 3- to 10- membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17d; and or R14and R14atogether form a C3-10 carbocycle, or 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, or 3- to 10-membered heterocycle, is optionally substituted with one or more substituents independently selected from R17d;R15is selected from: halogen, -OR18e, -SR18e, -N(R18e)2, -NO2, and -CN;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from R17e;C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from R17e;R16is selected from: hydrogen; andC1-6 alkyl optionally substituted with one or more substituents independently selected from R17f; each R17, R17a, R17b, R17c, R17d, R17e, and R17fis independently selected from:hydrogen, halogen, -CN, -OH, -SH, -NO2, -NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, - N(CI-6 alkyl)2, and -NH(CI-6 alkyl); andC1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10- membered heterocycle, and Ci-e haloalkyl; each R18, R18a, R18b, R18c, R18d, and R18eis independently selected from: hydrogen, halogen, -CN, -OH, -SH, -NO2, -NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, - N(CI-6 alkyl)2, and -NH(CI-6 alkyl); andC1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10- membered heterocycle, and Ci-e haloalkyl.

[0127] In some embodiments, for a compound or salt of Formula (II), or Formula (II-A), X11, X12, X13, and X14are each independently selected from C(R10). In some embodiments, at least one of X11, X12, X13, and X14need not be N.

[0128] In some embodiments, for a compound or salt of Formula (II), or Formula (II-A), X11, X12, X13, and X14are each independently selected from C(R10) and N. In some embodiments, at least one of X11, X12, X13, and X14is N. In some embodiments, at least two of X11, X12, X13, and X14are N. In some embodiments, X11is N. In some embodiments, X12is N. In some embodiments, X13is N. In some embodiments, X14is N. In some embodiments, X11, X12, X13, and X14are independently selected from C(R°) and N. In some embodiments, X11is selected from C(R°) and N. In some embodiments, X12is selected from C(R°) and N. In some embodiments, X13is selected from C(R°) and N. In some embodiments, X14is selected from C(R°) and N. In some embodiments, X11isselected from C(R°) and N. In some embodiments, X13is selected from C(R°) and N. In some embodiments, X14is selected from C(R°) and N. In some embodiments, X11is selected from C(H), C(halogen) and N. In some embodiments, X12is selected from C(H), C(halogen) and N. In some embodiments, X13is selected from C(H), C(halogen) and N. In some embodiments, X14is selected from C(H), C(halogen) and N. In some embodiments, X11is selected from C(H) and C(halogen). In some embodiments, X12is selected from C(H) and C(halogen). In some embodiments, X13is selected from C(H) and C(halogen). In some embodiments, X14is selected from C(H) and C(halogen). In some embodiments, X11is selected from C(H) and C(F). In some embodiments, X12is selected from C(H) and C(F). In some embodiments, X13is selected from C(H) and C(F). In some embodiments, X14is selected from C(H) and C(F). In some embodiments, X11is selected from C(H). In some embodiments, X12is selected from C(H). In some embodiments, X13is selected from C(H). In some embodiments, X14is selected from C(H). In some embodiments, X11is selected from C(F). In some embodiments, X12is selected from C(F). In some embodiments, X13is selected from C(F). In some embodiments, X14is selected from C(F). In some embodiments, X13is selected from C(H), and X14is selected from C(H). In some embodiments, X11is selected from C(F), and X12is selected from C(F). In some embodiments, X11is selected from C(H), and X12is selected from C(H). In some embodiments, X11is selected from C(F), and X12is selected from C(H). In some embodiments, X11is selected from C(H), and X12is selected from C(F)In some embodiments, for a compound or salt of Formula (II), or Formula (II-A), each R10is independently selected from: hydrogen, halogen, -NO2, -CN, -N3, -OR18, -SR18, -N(R18)2, -C(O)R18, -C(O)N(R18)2, - N(R18)C(O)R18, -OC(O)N(R18)2, -C(O)OR18, -OC(O)R18, and -S(O)2R18;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR18, -SR18, - N(R18)2, -C(O)R18, -C(O)N(R18)2, -N(R18)C(O)R18-C(O)OR18, -OC(O)R18, - N(R18)C(O)N(R18)2, -OC(O)N(R18)2, -N(R18)C(O)OR18, -S(O)R18, -S(O)2R18, =0, =S, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle; and

[0129] C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR18, -SR18, -N(R18)2, -C(O)R18, -C(O)N(R18)2, -N(R18)C(O)R18-C(O)OR18, -OC(O)R18, -N(R18)C(O)N(R18)2, - OC(O)N(R18)2, -N(R18)C(O)OR18, -S(O)R18, -S(O)2R18, =O, =S, -CN, C1-6 alkyl, C2.6alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R17. In some embodiments, for a compound or salt of Formula (II), or Formula (II-A), each R10is independently selected from:hydrogen, halogen, -NO2, -CN, -N3, -OR18, -SR18, -N(R18)2, -C(O)R18, -C(O)N(R18)2, - N(R18)C(O)R18, -N(R18)C(O)N(R18)2, -OC(O)N(R18)2, -N(R18)C(O)OR18, -C(O)OR18, - OC(O)R18, -S(O)R18, and -S(O)2R18;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR18, -SR18, -N(R18)2, -C(O)R18, - C(O)N(R18)2, -N(R18)C(O)R18, -C(O)OR18, -OC(O)R18, -N(R18)C(O)N(R18)2, - OC(O)N(R18)2, -N(R18)C(O)OR18, -S(O)R18, -S(O)2R18, -NO2, =0, =S, =N(R18), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10- membered heterocycle are each optionally substituted with one or more substituents independently selected from R17; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR18, -SR18, - N(R18)2, -C(0)R18, -C(O)N(R18)2, -N(R18)C(O)R18-N(R18)C(O)N(R18)2, -OC(O)N(R18)2, - N(R18)C(O)OR18, -C(0)0R18, -0C(0)R18, -S(O)R18, -S(O)2R18, -N02, =0, =S, =N(R18), - CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R17.

[0130] In some embodiments, for a compound or salt of Formula (II), or Formula (II-A), each R10is independently selected from: hydrogen, -F, -Cl, -Br, -I, -NO2, -CN, -N3, -OR18, -SR18, -N(R18)2, -C(O)R18, -C(O)N(R18)2, -N(R18)C(O)R18-OC(O)N(R18)2, -C(O)OR18, -OC(O)R18, and - S(O)2R18. In some embodiments, each R10is independently selected from: hydrogen, halogen, - NO2, -CN, -OR18, and -SR18; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR18, -SR18, -N(R18)2, -NO2, =0, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R17; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR18, -SR18, -N(R18)2, -NO2, =0, -CN, C1-6 alkyl, wherein each C1-6 alkyl is optionally substituted with one or more substituents independently selected from R17. In some embodiments, each R10is independently selected from: hydrogen, halogen, -CN, -N02, -OH, -O(Ci-6alkyl), -O(Ci-6haloalkyl), -SH, -S(Ci-6alkyl), -NH2, -NH(CI-6alkyl), and -N(CI-6 alkyl)2; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, -N02, -OH, -0(Ci-6 alkyl), -0(Ci-6 haloalkyl), -SH, - S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionallysubstituted with one or more substituents independently selected from R17; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -O(Ci-6 alkyl), -O(Ci-6 haloalkyl), -SH, -S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, C1-6 alkyl, and C 1-6 haloalkyl, wherein each C1-6 alkyl is optionally substituted with one or more substituents independently selected from R17. In some embodiments, each R10is independently selected from: hydrogen, halogen, -CN, -NO2, -OH, -O(Ci-6alkyl), -O(Ci-6haloalkyl), -SH, -S(Ci-6alkyl), -NH2, -NH(CI-6alkyl), and -N(CI-6 alkyl)2; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -O(Ci-6 alkyl), -O(Ci-6 haloalkyl), -SH, - S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, - O(Ci-6 alkyl), -O(Ci-6 haloalkyl), -SH, -S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, and Ci- 6 alkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, - O(Ci-6alkyl), -O(Ci-6haloalkyl), -SH, -S(Ci-6alkyl), -NH2, -NH(CI-6alkyl), -N(CI-6alkyl)2, Ci-6alkyl, and C1-6 haloalkyl. In some embodiments, each R10is independently selected from: hydrogen, halogen, -CN, -NO2, -OH, -O(Ci-6alkyl), -O(Ci-6haloalkyl), -SH, -S(Ci-6alkyl), -NH2, -NH(CI-6alkyl), and -N(CI-6 alkyl)2; C1-6 alkyl, optionally substituted with one or more substituents independently selected from -CN, -NO2, -OH, -O(Ci-6 alkyl), -O(Ci-6 haloalkyl), -SH, -S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, C3-10 carbocycle and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -O(Ci-6 alkyl), -O(Ci-6 haloalkyl), -SH, -S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, C1-6 alkyl, and Ci -6 haloalkyl. In some embodiments, each R10is independently selected from: hydrogen, halogen, - CN, -NO2, -OH, -O(Ci-6alkyl), -O(Ci-6haloalkyl), -SH, -S(Ci-6alkyl), -NH2, -NH(CI-6alkyl), and - N(CI-6 alkyl)2; C1-6 alkyl, and C1-6 haloalkyl each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -OH, -0(CH , -O(CF3), -NH2, -NH(CH3), - N(CHs)2, -SH, -S(CH3), -CH3, and -CF3; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from - F, -Cl, -OH, -O(CH3), -O(CF3), -NH2, -NH(CH3), -N(CH3)2, -SH, -S(CH3), -CH3, and -CF3. In some embodiments, each R10is independently selected from: hydrogen, halogen, -CN, -NO2, -OH, -O(Cn 6 alkyl), -O(Ci-6 haloalkyl), -SH, -S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), and -N(CI-6 alkyl)2; C1-6 alkyl, and C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle. In someembodiments, each R10is independently selected from: hydrogen, halogen, -CN, -NO2, -OH, -O(Ci- 6 alkyl), -O(Ci-6 haloalkyl), -SH, -S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), and -N(CI-6 alkyl)2; C1-6 alkyl, and C1-6 haloalkyl. In some embodiments, each R10is independently selected from: hydrogen, -CN, -F, -Cl, -OH, -O(CH3), -O(CF3), -NH2, -NH(CH3), -N(CH3)2, -SH, -S(CH3), -CH3, and -CF3. In some embodiments, each R10is independently selected from: hydrogen, -CN, -F, -Cl, -OH, - O(CH3), and -O(CF3). In some embodiments, each R10is independently selected from: hydrogen, - CN, -F, and -Cl. In some embodiments, each R10is independently selected from: hydrogen, -CN, and -F. In some embodiments, each R10is independently selected from: hydrogen, and -F. In some embodiments, each R10is independently selected from: hydrogen.

[0131] In some embodiments, for a compound or salt of Formula (II), or Formula (II-A), each R10is independently selected from: hydrogen, -F, -Cl, -Br, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl. In some embodiments, R10is selected from: methyl, ethyl, w-propyl, and isopropyl. In some embodiments, each R10is independently selected from hydrogen. In some embodiments, each R10is independently selected from -H and halogen. In some embodiments, each R10is independently selected from -H and -F. In some embodiments, each R10is independently selected from -F.In some embodiments, for a compound or salt of Formula (II), or Formula (II-A), R11is independently selected from: hydrogen;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR18a, -N(R18a)2, -C(O)R18a, - C(O)N(R18a)2, -N(R18a)C(O)R18a, -C(O)OR18a, -OC(O)R18a, -CN, C3-no carbocycle, and 3- to 110-membered heterocycle, wherein the C3-no carbocycle, and 3- to 110-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17a; andC3-io carbocycle, and 3- to 110-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR18a, - N(R18a)2, -C(O)R18a, -C(O)N(R18a)2, -N(R18a)C(O)R18a, -C(O)OR18a, -OC(O)R18a, -CN, Cn-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein Cn-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R17a; orR11together with R12form a C3-no carbocycle, or 3- to 110-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR18a, -N(R18a)2, -C(O)R18a, -C(O)N(R18a)2, -N(R18a)C(O)R18a, -C(O)OR18a, - OC(O)R18a, -CN, Cn-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein Cn-6 alkyl, C2-6 alkenyl,and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R17a.

[0132] In some embodiments, for a compound or salt of Formula (II), or Formula (II-A), R11is independently selected from: hydrogen;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR18a, -N(R18a)2, -C(O)R18a, - C(O)N(R18a)2, -N(R18a)C(O)R18a, -C(O)OR18a, -OC(O)R18a, -CN, C3-6 carbocycle, and 3- to 6-membered heterocycle, wherein the C3-6 carbocycle, and 3- to 6-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17a; andC3-6 carbocycle, and 3- to 6-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR18a, -N(R18a)2, -C(O)R18a, -C(O)N(R18a)2, -N(R18a)C(O)R18a, -C(O)OR18a, -OC(O)R18a, -CN, Cn-6alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein Cn-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R17a.

[0133] In some embodiments, for a compound or salt of Formula (II), or Formula (II-A), R11together with R12form a C3-6 carbocycle, or 3- to 6-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR18a, - N(R18a)2, -C(O)R18a, -C(O)N(R18a)2, -N(R18a)C(O)R18a, -C(O)OR18a, -OC(O)R18a, -CN, Cn-6alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein Cn-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R17a.

[0134] In some embodiments, for a compound or salt of Formula (II), or Formula (II-A), R11is independently selected from: methyl, ethyl, w-propyl, and isopropyl. In some embodiments, R11is hydrogen. In some embodiments, R11is methyl. In some embodiments, for a compound or salt of Formula (II-A), R12is selected from:C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR18b, -SR18b, - N(R18b)2, -C(O)R18b, -C(O)N(R18b)2, -N(R18b)C(O)R18b-N(R18b)C(O)N(R18b)2, - OC(O)N(R18b)2, -N(R18b)C(O)OR18b, -C(O)OR18b, -OC(O)R18b, -S(O)R18b, -S(O)2R18b, -NO2, =0, =S, =N(R18b), -CN, -N3, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17b; orR12together with R13form a 5- to 20-membered heterocycloalkenyl or 3- to 20-membered heterocycloalkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8a, -SR8a, -N(R8a)2, -C(O)R8a, -C(O)N(R8a)2, - N(R8a)C(O)R8a, -N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, -N(R8a)C(O)OR8a, -C(O)OR8a, - OC(O)R8a, -S(O)R8a, -S(O)2R8a, -NO2, =0, =S, =N(R8a), -CN, Ci-6alkyl, C2-6alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R17b.

[0135] In some embodiments, for a compound or salt of Formula (II-A), R12is selected from:C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR18b, -SR18b, - N(R18b)2, -C(0)R18b, -C(O)N(R18b)2, -N(R18b)C(O)R18b-N(R18b)C(O)N(R18b)2, - OC(O)N(R18b)2, -N(R18b)C(O)OR18b, -C(0)0R18b, -0C(0)R18b, -S(O)R18b, -S(O)2R18b, -NO2, =0, =S, =N(R18b), -CN, -N3, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17b; orR12together with R13form a 3- to 20-membered heterocycloalkyl (e.g., 3- to 10-membered heterocycloalkyl), each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8a, -SR8a, -N(R8a)2, -C(0)R8a, -C(O)N(R8a)2, - N(R8a)C(O)R8a, -N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, -N(R8a)C(O)OR8a, -C(0)0R8a, - 0C(0)R8a, -S(O)R8a, -S(O)2R8a, -NO2, =0, =S, =N(R8a), -CN, Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R17b.

[0136] In some embodiments, for a compound or salt of Formula (II, R12is selected from: hydrogen;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR18b, -SR18b, -N(R18b)2, -C(0)R18b, -C(O)N(R18b)2, -C(0)0R18b, -S(O)2R18b, =0, =S, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17b; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR18b, -SR18b, - N(R18b)2, -C(O)R18b, -C(O)N(R18b)2, -C(O)OR18b, -S(O)2R18b, =0, =S, -CN, -N3, Ci-6alkyl, C2-6 alkenyl, and C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17b; or

[0137] R12together with R13form a C3-10 carbocycle, or 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR18b, -SR18b, -N(R18b)2, -C(O)R18b, -C(O)N(R18b)2, -C(O)OR18b, -S(O)2R18b, =0, =S, -CN, Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17b.In some embodiments, for a compound or salt of Formula (II), or Formula (II-A), R12is selected from: C3-6 carbocycle, and 3- to 6-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -NH2, =0, Ci-6 alkyl, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle, and - C(O)N(R18b)2. In some embodiments, R12is selected from: phenyl, pyridyl, pyrimidyl, pyridazinyl, pyrimidinyl, and pyrazinyl, wherein each phenyl, pyridyl, pyrimidyl, pyridazinyl, pyrimidinyl, and pyrazinyl is optionally substituted with one or more substituents independently selected from halogen, -CN, -C(O)N(R18b)2, and Ci-6 alkyl. In some embodiments, R12is pyridyl. In some embodiments, R12is phenyl. In some embodiments,some embodiments,, .In some embodiments, for a compound or salt of Formula (II), or Formula (II-A), R13is selected from: hydrogen; and Ci-6 alkyl optionally substituted with one or more substituents independently selected from R17c. In some embodiments, R13is selected from hydrogen, methyl, ethyl, w-propyl, and isopropyl. In some embodiments, R13is -CH3. In some embodiments, R13is -F. In some embodiments, R13is hydrogen.

[0138] In some embodiments, for a compound or salt of Formula (II), or Formula (II-A), R12together with R13form a 3- to 20-membered heterocycloalkyl or 3- to 20-membered heterocycloalkenyl, each of which is optionally substituted with one or more substituentsindependently selected from halogen, -OR8a, -SR8a, -N(R8a)2, -C(O)R8a, -C(O)N(R8a)2, - N(R8a)C(O)R8a, -N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, -N(R8a)C(O)OR8a, -C(O)OR8a, -OC(O)R8a, - S(O)R8a, -S(O)2R8a, -NO2, =0, =S, =N(R8a), -CN, Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R17b. In some embodiments, R12together with R13form a 3- to 20-membered heterocycloalkyl or 5- to 20-membered heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R8a, - SR8a, -N(R8a)2, -C(0)R8a, -C(O)N(R8a)2, -N(R8a)C(O)R8a, -N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, - N(R8a)C(O)OR8a, -C(0)0R8a, -0C(0)R8a, -S(O)R8a, -S(O)2R8a, -N02, =0, =S, =N(R8a), -CN, Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R17b. In some embodiments, R12together with R13form a 3- to 20-membered heterocycloalkyl or 5- to 20- membered heterocycloalkenyl, optionally substituted with one or more substituents independently selected from halogen, -0R8a, -SR8a, -N(R8a)2, -C(0)R8a, -C(O)N(R8a)2, -N(R8a)C(O)R8a, - N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, -N(R8a)C(O)OR8a, -C(0)0R8a, -0C(0)R8a, -S(O)R8a, - S(O)2R8a, -NO2, =0, =S, =N(R8a), -CN, Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R17b. In some embodiments, R12together with R13form a 3- to 20- membered heterocycloalkyl (e.g., 5- to 20-membered heterocycle) or 5- to 20-membered heterocycloalkenyl (e.g., 5- to 10-membered heterocycloalkenyl), each of which is optionally substituted with one or more substituents independently selected from =0, Ci-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein Ci-6 alkyl, C3-10 carbocycle and 3- to 10- membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17b. In some embodiments, R12together with R13form a 3- to 20-membered heterocycloalkyl or a 5- to 20-membered heterocycloalkenyl , each of which is optionally substituted with one or more substituents independently selected from =0, Ci-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein Ci-6 alkyl, C3-10 carbocycle and 3- to 10- membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17b. In some embodiments, R12together with R13form a 3- to 20-membered heterocycloalkyl or a 5- to 20-membered heterocycloalkenyl, each of which is optionally substituted with =0. In some embodiments, R12together with R13form a 3- to 20-memberedheterocycloalkyl or a 5- to 20-membered heterocycloalkenyl , each of which is optionally substituted with Ci-6 alkyl optionally substituted with one or more substituents independently selected from R17b. In some embodiments, R12together with R13form a 3- to 20-membered heterocycloalkyl or a 5- to 20-membered heterocycloalkenyl , each of which is optionally substituted with C3-10 carbocycle optionally substituted with one or more substituents independently selected from R17b. In some embodiments, R12together with R13form a 3- to 20-membered heterocycloalkyl or a 5- to 20-membered heterocycloalkenyl, each of which is optionally substituted with a C3-10 carbocycle or 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from R17b. In some embodiments, R12together with R13form a 3- to 20-membered heterocycloalkyl or a 5- to 20-membered heterocycloalkenyl, each of which is optionally substituted with a C3-10 carbocycle or 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -O(Ci-6alkyl), -O(Ci-6haloalkyl), -SH, -S(Ci-6alkyl), -NH2, -NH(CI-6alkyl), -N(CI-6 alkyl)2, C1-6 alkyl and C1-6 haloalkyl. In some embodiments, R12together with R13form a 3- to 20-membered heterocycloalkyl or a 5- to 20-membered heterocycloalkenyl, each of which is optionally substituted with a C3-10 carbocycle or 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -CN, -F, - Cl, -OH, -O(CH3), -O(CF3), -NH2, -NH(CH3), -N(CH3)2, -SH, -S(CH3), -CH3, and -CF3. In some embodiments, R12together with R13form a 3- to 20-membered heterocycloalkyl or a 5- to 20- membered heterocycloalkenyl, each of which is optionally substituted with a C3-10 carbocycle or 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -CN, -F, -Cl, -OH, -O(CH3), -O(CF3), -NH2, -NH(CH3), -N(CH3)2, - SH, -S(CH3), -CH3, and -CF3. In some embodiments, R12together with R13form a 3- to 20- membered heterocycloalkyl or a 5- to 20-membered heterocycloalkenyl optionally substituted with a C3-10 carbocycle or 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from - -F, -0(CH , =0, -CH3, and N-morpholino. In some embodiments, R12together with R13form a 3- to 20-membered heterocycloalkyl or a 5- to 20-membered heterocycloalkenyl, each of which is optionally substituted with a C3-10 carbocycle or 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from - -F, -0(CH , =0, and -CH3. In some embodiments, R12together with R13form a 3- to 20-membered heterocycloalkyl or a 5- to 20-membered heterocycloalkenyl, each of which is optionally substituted with a C3-10 carbocycle or 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, and -CH3. In some embodiments, R12together with R13form a 3- to20-membered heterocycloalkyl or a 5- to 20-membered heterocycloalkenyl, each of which is optionally substituted with a C3-10 carbocycle or 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F. In some embodiments, R12together with R13form a 3- to 20-membered heterocycloalkyl or a 5- to 20- membered heterocycloalkenyl, each of which is optionally substituted with a C3-10 carbocycle or 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -CH3. In some embodiments, R12together with R13form a 3- to 20- membered heterocycloalkyl or a 5- to 20-membered heterocycloalkenyl, each of which is optionally substituted with a C3-10 carbocycle or 3- to 10-membered heterocycle, each of which is optionally substituted. In some embodiments, R12together with R13form a 3- to 20-membered heterocycloalkyl or a 5- to 20-membered heterocycloalkenyl, each of which is optionally substituted with a C3-10 carbocycle or 3- to 10-membered heterocycle.

[0139] In some embodiments, for a compound or salt of Formula (II), or Formula (II-A), R12together with R13form an optionally substituted 3- to 20-membered heterocycloalkyl or a 5- to 20- membered heterocycloalkenyl. In some embodiments, R12together with R13form an optionally substituted 3- to 20-membered heterocycloalkyl or a 5- to 20-membered heterocycloalkenyl

[0140] In some embodiments, for a compound or salt of Formula (II), or Formula (II-A), R14is selected from: hydrogen; and Ci alkyl, C2 alkyl, C3 alkyl, C4 alkyl, C5 alkyl, and Ce alkyl, wherein each Ci alkyl, C2 alkyl, C3 alkyl, C4 alkyl, C5 alkyl, and Ce alkyl is optionally substituted with one or more substituents independently selected from halogen, -OR18d, -SR18d, -N(R18d)2, -NO2, and -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle, and 3- to 10- membered heterocycle is optionally substituted with one or more substituents independently selected from R17d; and C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle, and 3- to 10-membered heterocycle, is optionally substituted with one or more substituents independently selected from R17d; or R14and R14atogether form a C3-10 carbocycle, or 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, or 3- to 10-membered heterocycle, is optionally substituted with one or more substituents independently selected from R17d. In some embodiments, R14is selected from: hydrogen; and Ci alkyl, C2 alkyl, C3 alkyl, C4 alkyl, C5 alkyl, and Ce alkyl, wherein each Ci alkyl, C2 alkyl, C3 alkyl, C4 alkyl, C5 alkyl, and Ce alkyl is substituted with one or more substituents independently selected from halogen, -OR18d, -SR18d, -N(R18d)2, -NO2, and -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R17d; and C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle, and 3- to 10-membered heterocycle, is optionally substituted with one or more substituents independently selected from R17d; or R14and R14atogether form a C3-10 carbocycle, or 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, or 3- to 10-membered heterocycle, is optionally substituted with one or more substituents independently selected from R17d. In some embodiments, R14is selected from: hydrogen; and C1-6 alkyl substituted with one or more substituents independently selected from halogen, -OR18d, -SR18d, -N(R18d)2, -NO2, and -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17d.

[0141] In some embodiments, R14is selected from: hydrogen; and Ci-6 alkyl substituted with one or more substituents independently selected from halogen, -OR18d, -SR18d, -N(R18d)2, -NO2, and -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10- membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17d. In some embodiments, R14is hydrogen. In some embodiments, for a compound or salt of Formula (II), or Formula (II-A), R14ais selected from: hydrogen, halogen, -OR18e, -SR8e, -N(R18e)2, -NO2, and -CN; andCi alkyl, C2 alkyl, C3 alkyl, C4 alkyl, C5 alkyl, and Ce alkyl, wherein each Ci alkyl, C2 alkyl, C3 alkyl, C4 alkyl, C5 alkyl, and Ce alkyl is optionally substituted with one or more substituents independently selected from halogen, -OR18d, -SR18d, -N(R18d)2, -NO2, and -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10- membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17d; orR14and R14atogether form a C3-10 carbocycle, or 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, or 3- to 10-membered heterocycle, is optionally substituted with one or more substituents independently selected from R17d.

[0142] In some embodiments, R14ais selected from: hydrogen, halogen, -OR18e, -SR8e, -N(R18e)2, -NO2, and -CN; andC1-6 alkyl substituted with one or more substituents independently selected from halogen, - OR18d, -SR18d, -N(R18d)2, -NO2, and -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17d; or R14and R14atogether form a C3-10 carbocycle, or 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, or 3- to 10-membered heterocycle, is optionally substituted with one or more substituents independently selected from R17d.

[0143] In some embodiments, R14ais selected from: hydrogen, halogen, -OR18e, -SR8e, -N(R18e)2; and C1-6 alkyl substituted with one or more substituents independently selected from halogen, - OR18d, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17d. In some embodiments, R14ais selected from: hydrogen, , -OR18e, - N(R18e)2; and C1-6 alkyl substituted with one or more substituents independently selected from halogen, -OR18d, C3 -10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17d. In some embodiments, R14ais selected from: hydrogen, , -OR18e, -N(R18e)2; and Ci-6 alkyl substituted with one or more substituents independently selected from halogen, -OR18d, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R14ais selected from: hydrogen, , -OR18e, -N(R18e)2; and C1-6 alkyl. In some embodiments, R14ais selected from: hydrogen and C1-6 alkyl. In some embodiments, R14ais selected from: hydrogen and Ci alkyl. In some embodiments, R14ais selected from: hydrogen. In some embodiments, R14ais selected from: hydrogen, C1-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R14ais selected from: methyl, ethyl, w-propyl, and isopropyl. In some embodiments, R14ais hydrogen. In some embodiments, for a compound or salt of Formula (II), or Formula (II-A), R15is selected from: halogen, -OR18e, -SR8e, -N(R18e)2, -NO2, and -CN;Ci alkyl, C2 alkyl, C3 alkyl, C4 alkyl, C5 alkyl, and Ce alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each Ci alkyl, C2 alkyl, C3 alkyl, C4 alkyl, C5 alkyl, Ce alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R17e; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from R17e.

[0144] In some embodiments, R15is selected from: halogen, -OR18e, -SR8e, -N(R18e)2, -NO2, and -CN;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from R17e;C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from R17e. In some embodiments, R15is selected from: C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from R17e; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from R17e.

[0145] In some embodiments, R15is selected from: C1-6 alkyl, optionally substituted with one or more substituents independently selected from R17e; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from R17e. In some embodiments, R15is selected from: Ci alkyl substituted with one or more substituents independently selected from R17e; C2-6 alkyl, optionally substituted with one ormore substituents independently selected from R17e; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from R17e. In some embodiments, R15is selected from: C1-2 alkyl substituted with one or more substituents independently selected from R17e; C3-6 alkyl, optionally substituted with one or more substituents independently selected from R17e; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from R17e. In some embodiments, R15is selected from: C1-3 alkyl substituted with one or more substituents independently selected from R17e; C4-6 alkyl, optionally substituted with one or more substituents independently selected from R17e; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from R17e. In some embodiments, R15is selected from: C1-4 alkyl substituted with one or more substituents independently selected from R17e; C5-6 alkyl, optionally substituted with one or more substituents independently selected from R17e; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from R17e. In some embodiments, R15is selected from: C3-10 carbocycle, and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from R17e. In some embodiments, R15is selected from C3-10 carbocycle, optionally substituted with one or more substituents independently selected from R17e. In some embodiments, R15is selected from 3- to 10-membered heterocycle, optionally substituted with one or more substituents independently selected from R17e. In some embodiments, R15is selected from 3- to 6-membered heterocycle, optionally substituted with one or more substituents independently selected from R17e. In some embodiments, R15is selected from azetidine and oxetane, optionally substituted with one or more substituents independently selected from R17e. In some embodiments, R15is selected from methyl. In some embodiments, R15is selected from -F.

[0146] In some embodiments, for a compound or salt of Formula (II), or Formula (II-A), R15is,

[0147] In some embodiments, for a compound or salt of Formula (II) or (II-A), R14and R14atogether form a C3-10 carbocycle, or 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, or 3- to 10-membered heterocycle, is optionally substituted with one or more substituents independently selected from R17d. In some embodiments, R14and R14atogether form a C3-10 carbocycle, or 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, or 3- to 10-membered heterocycle, is optionally substituted with one or more substituents independently selected fromhalogen, -CN, -NO2, -OH, -O(Ci-6alkyl), -O(Ci-6haloalkyl), -SH, -S(Ci-6alkyl), -NH2, -NH(CI-6alkyl), -N(CI-6 alkyl)2, C1-6 allkyl and C1-6 haloalkyl. In some embodiments, R14and R14atogether form a C3-10 carbocycle, or 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, or 3- to 10-membered heterocycle, is optionally substituted with one or more substituents independently selected from -CN, -F, -Cl, -OH, -O(CH3), -O(CF3), -NH2, -NH(CH3), -N(CH3)2, -SH, -S(CH3), - CH3, and -CF3.

[0148] In some embodiments, for a compound or salt of Formula (II), or Formula (II-A), R16is selected from: hydrogen; and C1-6 alkyl optionally substituted with one or more substituents independently selected from R17f. In some embodiments, R16is selected from hydrogen, methyl, ethyl, w-propyl, and isopropyl. In some embodiments, R16is hydrogen. In some embodiments, for a compound or salt of Formula (II), or Formula (II-A)„ each R17is independently selected from: hydrogen, -F, -Cl, -Br, -I, -CN, -OH, -NO2, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, -CN, -OH, =0, -O-C1-6 alkyl, - N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, -CN, -OH, =0, =S, -O-C1-6 alkyl, - SO2-Ci-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C 1-6 haloalkyl.

[0149] In some embodiments, for a compound or salt of Formula (II), or Formula (II-A)„ each R17ais independently selected from: hydrogen, -F, -Cl, -Br, -I, -CN, -OH, -NO2, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, - Br, -I, -CN, -OH, =0, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10- membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, - CN, -OH, =0, =S, -O-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6alkyl, C2.6alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl.

[0150] In some embodiments, for a compound or salt of Formula (II), or Formula (II-A)„ each R17bis independently selected from: hydrogen, -F, -Cl, -Br, -I, -CN, -OH, -NO2, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, - Br, -I, -CN, -OH, =0, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10- membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which isoptionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, - CN, -OH, =0, =S, -O-Ci-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R17bis independently selected from: hydrogen, -F, -O-C1-6 alkyl; and C1-6 alkyl optionally substituted with one or more substituents independently selected from C3-10 carbocycle, and 3- to 10-membered heterocycle.

[0151] In some embodiments, for a compound or salt of Formula (II), or Formula (II-A)„ each R17cis independently selected from: hydrogen, -F, -Cl, -Br, -I, -CN, -OH, -NO2, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, - Br, -I, -CN, -OH, =0, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10- membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, - CN, -OH, =0, =S, -O-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-6 haloalkyl. In some embodiments, each R17cis independently selected from: hydrogen, -F, -O-C1-6 alkyl; and Ci-6 alkyl optionally substituted with one or more substituents independently selected from C3-10 carbocycle, and 3- to 10-membered heterocycle.

[0152] In some embodiments, for a compound or salt of Formula (II), or Formula (II-A)„ each R17dis independently selected from: hydrogen, -F, -Cl, -Br, -I, -CN, -OH, -NO2, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl); and Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, - Br, -I, -CN, -OH, =0, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10- membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, - CN, -OH, =0, =S, -O-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-6 haloalkyl. In some embodiments, each R17dis independently selected from: hydrogen, -F, -O-C1-6 alkyl; and Ci-6 alkyl optionally substituted with one or more substituents independently selected from C3-10 carbocycle, and 3- to 10-membered heterocycle.

[0153] In some embodiments, for a compound or salt of Formula (II), or Formula (II-A), each R17eis independently selected from: hydrogen, -F, -Cl, -Br, -I, -CN, -OH, -NO2, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl); and Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, -CN, -OH, =0, -O-Ci-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10- membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, - CN, -OH, =0, =S, -O-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R17eis independently selected from: hydrogen, -F, -O-C1-6 alkyl; and C1-6 alkyl optionally substituted with one or more substituents independently selected from C3-10 carbocycle, and 3- to 10-membered heterocycle.

[0154] In some embodiments, for a compound or salt of Formula (II) or Formula (II-A), each R17fis independently selected from: hydrogen, -F, -Cl, -Br, -I, -CN, -OH, -NO2, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, - Br, -I, -CN, -OH, =0, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10- membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, - CN, -OH, =0, =S, -O-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-6 haloalkyl. In some embodiments, each R17fis independently selected from: hydrogen, -F, -O-C1-6 alkyl; and Ci-6 alkyl optionally substituted with one or more substituents independently selected from C3-10 carbocycle, and 3- to 10-membered heterocycle.

[0155] In some embodiments, for a compound or salt of Formula (II), or Formula (II-A), each R17gis independently selected from: hydrogen, -F, -Cl, -Br, -I, -CN, -OH, -NO2, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl); and Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, - Br, -I, -CN, -OH, =0, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10- membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, - CN, -OH, =0, =S, -O-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-6 haloalkyl. In some embodiments, each R17gis independently selected from: hydrogen, -F, -O-C1-6 alkyl; and Ci-6 alkyl optionally substituted with one or more substituents independently selected from C3-10 carbocycle, and 3- to 10-membered heterocycle.

[0156] In some embodiments, for a compound or salt of Formula (II), or Formula (II-A), each R18is independently selected from: hydrogen, -F, -Cl, -Br, -I, -CN, -OH, -NO2, -O-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl); and Ci-6 alkyl, C2-6 alkenyl, C 2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, - Br, -I, -CN, -OH, =0, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10- membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, - CN, -OH, =0, =S, -O-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, for a compound or salt of Formula (II), or Formula (II- A), each R18ais independently selected from: hydrogen, -F, -Cl, -Br, -I, -CN, -OH, -NO2, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, -CN, -OH, =0, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, -CN, -OH, =0, =S, -O-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R18ais independently selected from: hydrogen, halogen, -CN, -OH, -SH, -NO2, -NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, and -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O- C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2- 6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R18ais independently selected from: hydrogen; C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O- C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2- 6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R18ais independently selected from: hydrogen; C1-6 alkyl, optionally substitutedwith one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10- membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, - NH(CI-6 alkyl), C1-6 alkyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R18ais independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, - O(Ci-6alkyl), -O(Ci-6haloalkyl), -SH, -S(Ci-6alkyl), -NH2, -NH(CI-6alkyl), -N(CI-6alkyl)2, C3-10 carbocycle and 3-10 membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -0(Ci-6 alkyl), -0(Ci-6 haloalkyl), -SH, -S(Ci-6 alkyl), - NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, C1-6 alkyl, and C1-6 haloalkyl. In some embodiments, each R18ais independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from -CN, -F, -Cl, -OH, -0(CH , -0(CF3), -NH2, -NH(CH3), - N(CHs)2, -SH, -S(CH3), -CH3, and -CF3; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from - CN, -F, -Cl, -OH, -0(CH3), -O(CF3), -NH2, -NH(CH3), -N(CH3)2, -SH, -S(CH3), -CH3, and -CF3. In some embodiments, each R18ais independently selected from: hydrogen; C1-6 alkyl; C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, each R18ais independently selected from: hydrogen; C1-6 alkyl; and C1-6 haloalkyl (e.g., fluoroalkyl). In some embodiments, each R18ais independently selected from: hydrogen; and C1-6 alkyl. In some embodiments, each R18ais independently selected from: hydrogen; and C1-6 alkyl; and C3-10 carbocycle. In some embodiments, each R18ais independently selected from: hydrogen; and C1-6 alkyl; and C3-10 carbocycle, wherein the C3-10 carbocycle is [l. l.l]bicyclopentyl or cyclobutyl. In some embodiments, each R18ais independently selected from: hydrogen; and C1-5 alkyl. In some embodiments, each R18ais independently selected from: hydrogen; and C1-4 alkyl. In some embodiments, each R18ais independently selected from: hydrogen; and C1-3 alkyl. In some embodiments, each R18ais independently selected from: hydrogen; and C1-2 alkyl. In some embodiments, each R18ais independently selected from: hydrogen; and Ci alkyl. In some embodiments, each R18ais independently selected from: hydrogen. In some embodiments, each R18ais independently selected from: Ci alkyl.

[0157] In some embodiments, for a compound or salt of Formula (II), or Formula (II-A), each R18bis independently selected from: hydrogen, -F, -Cl, -Br, -I, -CN, -OH, -NO2, -O-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl); and Ci-6 alkyl, C2-6 alkenyl, C 2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, - Br, -I, -CN, -OH, =0, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10- membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, - CN, -OH, =0, =S, -O-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R18bis independently selected from: hydrogen, halogen, -CN, -OH, -SH, -NO2, - NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, and -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R18bis independently selected from: hydrogen; C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R18bis independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R18bis independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, - CN, -NO2, -OH, -O(Ci-6alkyl), -O(Ci-6haloalkyl), -SH, -S(Ci-6alkyl), -NH2, -NH(CI-6alkyl), -N(CI-6 alkyl)2, C3-10 carbocycle and 3-10 membered heterocycle; and C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -O(Ci-6 alkyl), -O(Ci-6 haloalkyl), -SH, - S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, C1-6 alkyl, and C1-6 haloalkyl. In some embodiments, each R18bis independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from -CN, -F, -Cl, -OH, -O(CH , -O(CF3), - NH2, -NH(CH3), -N(CH3)2, -SH, -S(CH3), -CH3, and -CF3; and C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -CN, -F, -Cl, -OH, -O(CH3), -O(CF3), -NH2, -NH(CH3), -N(CH3)2, - SH, -S(CH3), -CH3, and -CF3. In some embodiments, each R18bis independently selected from: hydrogen; C1-6 alkyl; C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, each R18bis independently selected from: hydrogen; C1-6 alkyl; and C1-6 haloalkyl (e.g., fluoroalkyl). In some embodiments, each R18bis independently selected from: hydrogen; and C1-6 alkyl. In some embodiments, each R18bis independently selected from: hydrogen; and C1-6 alkyl; and C3-10 carbocycle. In some embodiments, each R18bis independently selected from: hydrogen; and C1-6 alkyl; and C3-10 carbocycle, wherein the C3-10 carbocycle is [l.l. l]bicyclopentyl or cyclobutyl. In some embodiments, each R18bis independently selected from: hydrogen; and C1-5 alkyl. In some embodiments, each R18bis independently selected from: hydrogen; and C1-4 alkyl. In some embodiments, each R18bis independently selected from: hydrogen; and C1-3 alkyl. In some embodiments, each R18bis independently selected from: hydrogen; and C1-2 alkyl. In some embodiments, each R18bis independently selected from: hydrogen; and Ci alkyl. In some embodiments, each R18bis independently selected from: hydrogen. In some embodiments, each R18bis independently selected from: Ci alkyl.

[0158] In some embodiments, for a compound or salt of Formula (II), or Formula (II-A), each R18cis independently selected from: hydrogen, -F, -Cl, -Br, -I, -CN, -OH, -NO2, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C2-e alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, - Br, -I, -CN, -OH, =0, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10- membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, - CN, -OH, =0, =S, -O-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R18cis independently selected from: hydrogen, halogen, -CN, -OH, -SH, -NO2, - NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, and -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl,C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R18bis independently selected from: hydrogen; C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R18cis independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R18cis independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, - CN, -NO2, -OH, -O(Ci-6alkyl), -O(Ci-6haloalkyl), -SH, -S(Ci-6alkyl), -NH2, -NH(CI-6alkyl), - N(CI-6 alkyl)2, C3-10 carbocycle and 3-10 membered heterocycle; and C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -0(Ci-6 alkyl), -0(Ci-6 haloalkyl), -SH, - S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, C1-6 alkyl, and C1-6 haloalkyl. In some embodiments, each R18cis independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from -CN, -F, -Cl, -OH, -0(CH , -0(CF3), - NH2, -NH(CH3), -N(CH3)2, -SH, -S(CH3), -CH3, and -CF3; and C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -CN, -F, -Cl, -OH, -0(CH3), -O(CF3), -NH2, -NH(CH3), -N(CH3)2, -SH, -S(CH3), -CH3, and -CF3. In some embodiments, each R18cis independently selected from: hydrogen; C1-6 alkyl; C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, each R18cis independently selected from: hydrogen; C1-6 alkyl; and C1-6 haloalkyl (e.g., fluoroalkyl). In some embodiments, each R18cis independently selected from: hydrogen; and C1-6 alkyl. In some embodiments, each R18cis independently selected from: hydrogen; and C1-6 alkyl; and C3-10 carbocycle. In some embodiments, each R18cis independently selected from: hydrogen; and C1-6 alkyl; and C3-10 carbocycle, wherein the C3-10 carbocycle is [l.l. l]bicyclopentyl or cyclobutyl. In some embodiments, each R18cis independently selected from: hydrogen; and C1-5 alkyl. In some embodiments, each R18cis independently selected from: hydrogen; and C1-4 alkyl. In some embodiments, each R18cis independently selected from: hydrogen; and C1-3 alkyl. In some embodiments, each R18cis independently selected from: hydrogen; and C1-2 alkyl. In some embodiments, each R18cis independently selected from: hydrogen; and Ci alkyl. In some embodiments, each R18cis independently selected from: hydrogen. In some embodiments, each R18cis independently selected from: Ci alkyl.

[0159] In some embodiments, for a compound or salt of Formula (II), or Formula (II-A), each R18dis independently selected from: hydrogen, -F, -Cl, -Br, -I, -CN, -OH, -NO2, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C 2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, - Br, -I, -CN, -OH, =0, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10- membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, - CN, -OH, =0, =S, -O-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R18dis independently selected from: hydrogen, halogen, -CN, -OH, -SH, -NO2, - NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, and -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R18bis independently selected from: hydrogen; C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or moresubstituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R18dis independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R18dis independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, - CN, -NO2, -OH, -O(Ci-6alkyl), -O(Ci-6haloalkyl), -SH, -S(Ci-6alkyl), -NH2, -NH(CI-6alkyl), - N(CI-6 alkyl)2, C3-10 carbocycle and 3-10 membered heterocycle; and C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -0(Ci-6 alkyl), -0(Ci-6 haloalkyl), -SH, - S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, C1-6 alkyl, and C1-6 haloalkyl. In some embodiments, each R18dis independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from -CN, -F, -Cl, -OH, -0(CH , -0(CF3), - NH2, -NH(CH3), -N(CH3)2, -SH, -S(CH3), -CH3, and -CF3; and C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -CN, -F, -Cl, -OH, -0(CH3), -O(CF3), -NH2, -NH(CH3), -N(CH3)2, - SH, -S(CH3), -CH3, and -CF3. In some embodiments, each R18dis independently selected from: hydrogen; C1-6 alkyl; C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, each R18dis independently selected from: hydrogen; C1-6 alkyl; and C1-6 haloalkyl (e.g., fluoroalkyl). In some embodiments, each R18dis independently selected from: hydrogen; and C1-6 alkyl. In some embodiments, each R18dis independently selected from: hydrogen; and C1-6 alkyl; and C3-10 carbocycle. In some embodiments, each R18dis independently selected from: hydrogen; and C1-6 alkyl; and C3-10 carbocycle, wherein the C3-10 carbocycle is [l.l. l]bicyclopentyl or cyclobutyl. In some embodiments, each R18dis independently selected from: hydrogen; and C1-5 alkyl. In some embodiments, each R18dis independently selected from:hydrogen; and C1-4 alkyl. In some embodiments, each R18dis independently selected from: hydrogen; and C1-3 alkyl. In some embodiments, each R18dis independently selected from: hydrogen; and C1-2 alkyl. In some embodiments, each R18dis independently selected from: hydrogen; and Ci alkyl. In some embodiments, each R18dis independently selected from: hydrogen. In some embodiments, each R18dis independently selected from: Ci alkyl.

[0160] In some embodiments, for a compound or salt of Formula (II), or Formula (II-A), each R18eis independently selected from: hydrogen, -F, -Cl, -Br, -I, -CN, -OH, -NO2, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C 2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, - Br, -I, -CN, -OH, =0, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10- membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, - CN, -OH, =0, =S, -O-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R18eis independently selected from: hydrogen, halogen, -CN, -OH, -SH, -NO2, - NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, and -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R18eis independently selected from: hydrogen; C1-6 alkyl, C2- 6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O- C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R18eis independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R18eis independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, - CN, -NO2, -OH, -O(Ci-6alkyl), -O(Ci-6haloalkyl), -SH, -S(Ci-6alkyl), -NH2, -NH(CI-6alkyl), - N(CI-6 alkyl)2, C3-10 carbocycle and 3-10 membered heterocycle; and C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -O(Ci-6 alkyl), -O(Ci-6 haloalkyl), -SH, - S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, C1-6 alkyl, and C1-6 haloalkyl. In some embodiments, each R18eis independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from -CN, -F, -Cl, -OH, -0(CH , -O(CF3), - NH2, -NH(CH3), -N(CH3)2, -SH, -S(CH3), -CH3, and -CF3; and C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -CN, -F, -Cl, -OH, -O(CH3), -O(CF3), -NH2, -NH(CH3), -N(CH3)2, - SH, -S(CH3), -CH3, and -CF3. In some embodiments, each R18eis independently selected from: hydrogen; C1-6 alkyl; C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, each R18eis independently selected from: hydrogen; C1-6 alkyl; and C1-6 haloalkyl (e.g., fluoroalkyl). In some embodiments, each R18eis independently selected from: hydrogen; and C1-6 alkyl. In some embodiments, each R18eis independently selected from: hydrogen; and C1-6 alkyl; and C3-10 carbocycle. In some embodiments, each R18eis independently selected from: hydrogen; and C1-6 alkyl; and C3-10 carbocycle, wherein the C3-10 carbocycle is [l.l. l]bicyclopentyl or cyclobutyl. In some embodiments, each R18eis independently selected from: hydrogen; and C1-5 alkyl. In some embodiments, each R18eis independently selected from: hydrogen; and C1-4 alkyl. In some embodiments, each R18eis independently selected from: hydrogen; and C1-3 alkyl. In some embodiments, each R18eis independently selected from: hydrogen; and C1-2 alkyl. In some embodiments, each R18eis independently selected from: hydrogen; and Ci alkyl. In some embodiments, each R18eis independently selected from: hydrogen. In some embodiments, each R18eis independently selected from: Ci alkyl.

[0161] In some embodiments, for a compound or salt of Formula (II), or Formula (II-A), each R18fis independently selected from: hydrogen, -F, -Cl, -Br, -I, -CN, -OH, -NO2, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C2-e alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, -CN, -OH, =0, -O-Ci-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10- membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, - CN, -OH, =0, =S, -O-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R18fis independently selected from: hydrogen, halogen, -CN, -OH, -SH, -NO2, - NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, and -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R18bis independently selected from: hydrogen; C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R18fis independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R18fis independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, - CN, -NO2, -OH, -O(Ci-6alkyl), -O(Ci-6haloalkyl), -SH, -S(Ci-6alkyl), -NH2, -NH(CI-6alkyl), - N(CI-6 alkyl)2, C3-10 carbocycle and 3-10 membered heterocycle; and C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituentsindependently selected from halogen, -CN, -NO2, -OH, -O(Ci-6 alkyl), -O(Ci-6 haloalkyl), -SH, - S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, C1-6 alkyl, and C1-6 haloalkyl. In some embodiments, each R18fis independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from -CN, -F, -Cl, -OH, -O(CH3), -O(CF3), - NH2, -NH(CH3), -N(CH3)2, -SH, -S(CH3), -CH3, and -CF3; and C3-io carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -CN, -F, -Cl, -OH, -O(CH3), -O(CF3), -NH2, -NH(CH3), -N(CH3)2, - SH, -S(CH3), -CH3, and -CF3. In some embodiments, each R18fis independently selected from: hydrogen; C1-6 alkyl; C1-6 haloalkyl; and C3-io carbocycle and 3- to 10-membered heterocycle. In some embodiments, each R18fis independently selected from: hydrogen; C1-6 alkyl; and C1-6 haloalkyl (e.g., fluoroalkyl). In some embodiments, each R18fis independently selected from: hydrogen; and C1-6 alkyl. In some embodiments, each R18fis independently selected from: hydrogen; and C1-6 alkyl; and C3-io carbocycle. In some embodiments, each R18fis independently selected from: hydrogen; and C1-6 alkyl; and C3-io carbocycle, wherein the C3-io carbocycle is [l.l. l]bicyclopentyl or cyclobutyl. In some embodiments, each R18fis independently selected from: hydrogen; and C1-5 alkyl. In some embodiments, each R18fis independently selected from: hydrogen; and C1-4 alkyl. In some embodiments, each R18fis independently selected from: hydrogen; and Ci-3alkyl. In some embodiments, each R18fis independently selected from: hydrogen; and C1-2 alkyl. In some embodiments, each R18fis independently selected from: hydrogen; and Ci alkyl. In some embodiments, each R18fis independently selected from: hydrogen. In some embodiments, each R18fis independently selected from: Ci alkyl.

[0162] In some embodiments, for a compound or salt of Formula (II), or Formula (II-A), each R18gis independently selected from: hydrogen, -F, -Cl, -Br, -I, -CN, -OH, -NO2, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C 2-6 alkynyl, and C3-io carbocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, - Br, -I, -CN, -OH, =0, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-io carbocycle, 3- to 10- membered heterocycle; and C3-io carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -Br, -I, - CN, -OH, =0, =S, -O-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-io carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R18gis independently selected from: hydrogen, halogen, -CN, -OH, -SH, -NO2, - NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, and -NH(CI-6 alkyl); and C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-io carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6alkyl, -S-Ci-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R18gis independently selected from: hydrogen; C1-6 alkyl, C2- 6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O- C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R18gis independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R18gis independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, - CN, -NO2, -OH, -O(Ci-6alkyl), -O(Ci-6haloalkyl), -SH, -S(Ci-6alkyl), -NH2, -NH(CI-6alkyl), - N(CI-6 alkyl)2, C3-10 carbocycle and 3-10 membered heterocycle; and C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -0(Ci-6 alkyl), -0(Ci-6 haloalkyl), -SH, - S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, C1-6 alkyl, and C1-6 haloalkyl. In some embodiments, each R18gis independently selected from: hydrogen; C1-6 alkyl, optionally substituted with one or more substituents independently selected from -CN, -F, -Cl, -OH, -0(CH , -0(CF3), - NH2, -NH(CH3), -N(CH3)2, -SH, -S(CH3), -CH3, and -CF3; and C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -CN, -F, -Cl, -OH, -0(CH3), -O(CF3), -NH2, -NH(CH3), -N(CH3)2, - SH, -S(CH3), -CH3, and -CF3. In some embodiments, each R18gis independently selected from: hydrogen; C1-6 alkyl; C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle. Insome embodiments, each R18gis independently selected from: hydrogen; Ci-6 alkyl; and Ci-6 haloalkyl (e.g., fluoroalkyl). In some embodiments, each R18gis independently selected from: hydrogen; and Ci-6 alkyl. In some embodiments, each R18gis independently selected from: hydrogen; and Ci-6 alkyl; and C3-10 carbocycle. In some embodiments, each R18gis independently selected from: hydrogen; and C1-6 alkyl; and C3-10 carbocycle, wherein the C3-10 carbocycle is [l.l. l]bicyclopentyl or cyclobutyl. In some embodiments, each R18gis independently selected from: hydrogen; and C1-5 alkyl. In some embodiments, each R18gis independently selected from: hydrogen; and C1-4 alkyl. In some embodiments, each R18gis independently selected from: hydrogen; and C1-3 alkyl. In some embodiments, each R18gis independently selected from: hydrogen; and C1-2 alkyl. In some embodiments, each R18gis independently selected from: hydrogen; and Ci alkyl. In some embodiments, each R18gis independently selected from: hydrogen. In some embodiments, each R18gis independently selected from: Ci alkyl.

[0163] In some embodiments, for a compound or salt of Formula (II), or Formula (II-A), the compound is selected from:ʼnllor a salt thereof, wherein: n is independently selected from: 0, 1, and 2; each R20is independently selected from: hydrogen;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR28, -SR28, - N(R28)2, -C(O)R28, -C(O)N(R28)2, -N(R28)C(O)R28-C(O)OR28, -OC(O)R28, - N(R28)C(O)N(R28)2, -OC(O)N(R28)2, -N(R28)C(O)OR28, -S(O)R28, -S(O)2R28, -NO2, =0, =S, =N(R28), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3- 10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R27; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR28, - SR28, -N(R28)2, -C(O)R28, -C(O)N(R28)2, -N(R28)C(O)R28, -N(R28)C(O)N(R28)2, - OC(O)N(R28)2, -N(R28)C(O)OR28, -C(O)OR28, -OC(O)R28, -S(O)R28, -S(O)2R28, -NO2, =0, =S, =N(R28), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R27;R21is selected from: hydrogen;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR28a, -SR28a, - N(R28a)2, -C(O)R28a, -C(O)N(R28a)2, -N(R28a)C(O)R28a, -C(O)OR28a, -OC(O)R28a, - N(R28a)C(O)N(R28a)2, -OC(O)N(R28a)2, -N(R28a)C(O)OR28a, -S(O)R28a, -S(O)2R28a, -NO2, =0, =S, =N(R28a), -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R27a; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR28a, - SR28a, -N(R28a)2, -C(O)R28a, -C(O)N(R28a)2, -N(R28a)C(O)R28a, -N(R28a)C(O)N(R28a)2, - OC(O)N(R28a)2, -N(R28a)C(O)OR28a, -C(O)OR28a, -OC(O)R28a, -S(O)R28a, -S(O)2R28a, - NO2, =0, =S, =N(R28a), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R27a; orR21together with R22form a C3-10 cycloalkyl, C5-10 cycloalkenyl, 3- to 10- membered heterocycloalkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR28a, -SR28a, -N(R28a)2, -C(O)R28a, - C(O)N(R28a)2, -N(R28a)C(O)R28a, -N(R28a)C(O)N(R28a)2, -OC(O)N(R28a)2, - N(R28a)C(O)OR28a, -OC(O)R28a, -S(O)R28a, -S(O)2R28a, -N02, =0 , =S, =N(R28a), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R27a;R22is selected from: hydrogen;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR28b, -SR28b, - N(R28b)2, -C(O)R28b, -C(O)N(R28b)2, -N(R28b)C(O)R28b-C(O)OR28b, -OC(O)R28b, - N(R28b)C(O)N(R28b)2, -OC(O)N(R28b)2, -N(R28b)C(O)OR28b, -S(O)R28b, -S(O)2R28b, - NO2, =0, =S, =N(R28b), -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R27b; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR28b, - SR28b, -N(R28b)2, -C(O)R28b, -C(O)N(R28b)2, -N(R28b)C(O)R28b-N(R28b)C(O)N(R28b)2, -OC(O)N(R28b)2, -N(R28b)C(O)OR28b, -C(O)OR28b, -OC(O)R28b, -S(O)R28b, -S(O)2R28b, - N02, =0, =S, =N(R28b), -CN, -N3, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R27b; orR21together with R22form a C3-10 cycloalkyl, C5-10 cycloalkenyl, 3- to 10- membered heterocycloalkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR28a, -SR28a, -N(R28a)2, -C(O)R28a, - C(O)N(R28a)2, -N(R28a)C(O)R28a, -N(R28a)C(O)N(R28a)2, -OC(O)N(R28a)2, - N(R28a)C(O)OR28a, -OC(O)R28a, -S(O)R28a, -S(O)2R28a, -N02, =0 , =S, =N(R28a), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R27a; orR22together with R23form a 3- to 15-membered heterocycloalkyl or 5- to 15- membered heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR28a, -SR28a, -N(R28a)2, -C(O)R28a, - C(O)N(R28a)2, -N(R28a)C(O)R28a, -N(R28a)C(O)N(R28a)2, -OC(O)N(R28a)2, - N(R28a)C(O)OR28a, -C(O)OR28a, -OC(O)R28a, -S(O)R28a, -S(O)2R28a, -N02, =0-, =S, =N(R28a), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R27b;R23is selected from: hydrogen; andC1-6 alkyl optionally substituted with one or more substituents independently selected from R27c; orR22together with R23form a 3- to 15-membered heterocycloalkyl or 5- to 15- membered heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR28a, -SR28a, -N(R28a)2, -C(O)R28a, - C(O)N(R28a)2, -N(R28a)C(O)R28a, -N(R28a)C(O)N(R28a)2, -OC(O)N(R28a)2, - N(R28a)C(O)OR28a, -C(O)OR28a, -OC(O)R28a, -S(O)R28a, -S(O)2R28a, -N02, =0-, =S, =N(R28a), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R27b;R24is independently selected from: hydrogen, halogen, -OR28d, -SR28d, -N(R28d)2, -N02, and -CN; andCi-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR28d, -SR28d, -N(R28d)2, -NO2, and -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more R27d; orR24together with R24aform a C3-10 carbocycle, or 3- to 10-membered heterocycloalkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR28e, -SR28e, -N(R28e)2, -C(O)R28e, - C(O)N(R28e)2, -N(R28e)C(O)R28e, -N(R28e)C(O)N(R28e)2, -OC(O)N(R28e)2, - N(R28e)C(O)OR28e, -C(O)OR28e, -OC(O)R28e, -S(O)R28e, -S(O)2R28e, -NO2, =0-, =S, =N(R28e), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R27e;R24ais independently selected from: hydrogen, halogen, -OR28e, -SR28e, -N(R28e)2, -NO2, and -CN; andC1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR28e, -SR28e, -N(R28e)2, -NO2, and -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more R27e; orR24together with R24aform a C3-10 carbocycle, or 3- to 10-membered heterocycloalkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR28e, -SR28e, -N(R28e)2, -C(O)R28e, - C(O)N(R28e)2, -N(R28e)C(O)R28e, -N(R28e)C(O)N(R28e)2, -OC(O)N(R28e)2, - N(R28e)C(O)OR28e, -C(O)OR28e, -OC(O)R28e, -S(O)R28e, -S(O)2R28e, -N02, =0-, =S, =N(R28e), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R27e;R25is selected from: hydrogen, halogen, -OR28f, -SR28f, -N(R28f)2, -NO2, and -CN;Ci alkyl, optionally substituted with one or more substituents independently selected from -OH, -Cl, -Br, -CN, -OH, -SH, -N02, -NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, - N(CI-6 alkyl)2, and -NH(CI-6 alkyl), and C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-e haloalkyl; andC2-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C2-6 alkyl, C3-10 carbocycle, and 3- to 10- membered heterocycle are each optionally substituted with one or more substituents independently selected from R27f;R26is selected from: hydrogen; andC1-6 alkyl optionally substituted with one or more substituents independently selected from R27g; each R27, R27a, R27b, R27c, R27d, R27e, R27f, R27gis independently selected from: hydrogen, halogen, -CN, -OH, -SH, -NO2, -NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, - N(CI-6 alkyl)2, and -NH(CI-6 alkyl); andC1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10- membered heterocycle, and Ci-e haloalkyl; each R28, R28a, R28b, R28c, R28d, R28e, and R28fis independently selected from: hydrogen, halogen, -CN, -OH, -SH, -NO2, -NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, - N(CI-6 alkyl)2, and -NH(CI-6 alkyl); andC1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10- membered heterocycle, and Ci-e haloalkyl.

[0165] In some embodiments, for a compound or salt of Formula (III), n is selected from: 0, 1, and 2. In some embodiments, n is selected from 0 and 1. In ...

Claims

CLAIMSWHAT IS CLAIMED IS:

1. A compound represented by Formula (LA)or a salt thereof, wherein:X1, X2, X3, and X4are independently selected from C(R°) and N; each R° is independently selected from: hydrogen, halogen, -NO2, -CN, -N3, -OR8, -SR8, -N(R8)2, -C(O)R8, -C(O)N(R8)2, -N(R8)C(O)R8, -N(R8)C(O)N(R8)2, -OC(O)N(R8)2, -N(R8)C(O)OR8, -C(O)OR8, - OC(O)R8, -S(O)R8, and -S(O)2R8;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8, -SR8, - N(R8)2, -C(O)R8, -C(O)N(R8)2, -N(R8)C(O)R8, -C(O)OR8, -OC(O)R8, - N(R8)C(O)N(R8)2, -OC(O)N(R8)2, -N(R8)C(O)OR8, -S(O)R8, -S(O)2R8, -NO2, =0, =s, =N(R8), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R7; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8, - SR8, -N(R8)2, -C(O)R8, -C(O)N(R8)2, -N(R8)C(O)R8-N(R8)C(O)N(R8)2, -OC(O)N(R8)2, -N(R8)C(O)OR8, -C(O)OR8, -OC(O)R8, -S(O)R8, -S(O)2R8, -NO2, =0, =S, =N(R8), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R7; 1 is selected from: hydrogen;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R8a, -SR8a, - N(R8a)2, -C(0)R8a, -C(O)N(R8a)2, -N(R8a)C(O)R8a, -C(0)0R8a, -0C(0)R8a, - N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, -N(R8a)C(O)OR8a, -S(O)R8a, -S(O)2R8a, -N02, =0,=S, =N(R8a), -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3. io carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7a; andC3-io carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8a, - SR8a, -N(R8a)2, -C(O)R8a, -C(O)N(R8a)2, -N(R8a)C(O)R8a, -N(R8a)C(O)N(R8a)2, - OC(O)N(R8a)2, -N(R8a)C(O)OR8a, -C(O)OR8a, -OC(O)R8a, -S(O)R8a, -S(O)2R8a, -NO2, =0, =S, =N(R8a), -CN, Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R7a; orR1together with R2form a C3-io cycloalkyl, C5-10 cycloalkenyl, 3- to 10- membered heterocycloalkyl, or 5- to 10-membered heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8a, -SR8a, -N(R8a)2, -C(O)R8a, -C(O)N(R8a)2, -N(R8a)C(O)R8a, - N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, -N(R8a)C(O)OR8a, -C(O)OR8a, -OC(O)R8a, - S(O)R8a, -S(O)2R8a, -NO2, =0 , =S, =N(R8a), -CN, Ci-6alkyl, C2.6alkenyl, and C2.6alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R7a; ed from: hydrogen;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8b, -SR8b, - N(R8b)2, -C(O)R8b, -C(O)N(R8b)2, -N(R8b)C(O)R8b-C(O)OR8b, -OC(O)R8b, - N(R8b)C(O)N(R8b)2, -OC(O)N(R8b)2, -N(R8b)C(O)OR8b, -S(O)R8b, -S(O)2R8b, -NO2, =0, =S, =N(R8b), -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3. 10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7b; andC3-io carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8b, - SR8b, -N(R8b)2, -C(0)R8b, -C(O)N(R8b)2, -N(R8b)C(O)R8b-N(R8b)C(O)N(R8b)2, - OC(O)N(R8b)2, -N(R8b)C(O)OR8b, -C(0)0R8b, -0C(0)R8b, -S(O)R8b, -S(O)2R8b, -NO2, =0, =S, =N(R8b), -CN, -N3, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-io carbocycle and 3- to 10-membered heterocycle, wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-iocarbocycle and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7b; orR1together with R2form a C3-10 cycloalkyl, C5-10 cycloalkenyl, 3- to 10- membered heterocycloalkyl, or 5- to 10-membered heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8a, -SR8a, -N(R8a)2, -C(O)R8a, -C(O)N(R8a)2, -N(R8a)C(O)R8a, - N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, -N(R8a)C(O)OR8a, -C(O)OR8a, -OC(O)R8a, - S(O)R8a, -S(O)2R8a, -NO2, =0 , =S, =N(R8a), -CN, Ci-6alkyl, C2.6alkenyl, and C2.6alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R7a; orR2together with R3form a 3- to 15-membered heterocycloalkyl or 5- to 15- membered heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8a, -SR8a, -N(R8a)2, -C(0)R8a, - C(O)N(R8a)2, -N(R8a)C(O)R8a, -N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, - N(R8a)C(O)OR8a, -C(0)0R8a, -0C(0)R8a, -S(O)R8a, -S(O)2R8a, -NO2, =0-, =S, =N(R8a), -CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10- membered heterocycle, are each optionally substituted with one or more substituents independently selected from R713; ed from: hydrogen; andC1-6 alkyl optionally substituted with one or more substituents independently selected from R7c; orR2together with R3form a 3- to 15-membered heterocycloalkyl or 5- to 15- membered heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8a, -SR8a, -N(R8a)2, -C(0)R8a, - C(O)N(R8a)2, -N(R8a)C(O)R8a, -N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, - N(R8a)C(O)OR8a, -C(0)0R8a, -0C(0)R8a, -S(O)R8a, -S(O)2R8a, -NO2, =0-, =S, =N(R8a), -CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10- membered heterocycle, are each optionally substituted with one or more substituents independently selected from R713; ed from: halogen, -0R8d, -SR8d, -N(R8d)2, -N02, and -CN;C3-6 alkyl optionally substituted with one or more substituents independently selected from R7d; and-CH2F, -CHF2, and C2-6 alkyl optionally substituted with one or more -F;C1-6 alkyl substituted with one or more substituents independently selected from - Cl, -Br, -OR8d, -SR8d, -N(R8d)2, -NO2, and -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycleis optionally substituted with one or more substituents independently selected from R7d; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from R7d; orR4and R4atogether form a C4-10 carbocycle, or 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, or 3- to 10-membered heterocycle, is optionally substituted with one or more substituents independently selected from R7e;R4ais selected from: hydrogen, halogen, -OR8e, -SR8e, -N(R8e)2, -NO2, and -CN; and-CH2F, -CHF2, and C2-6 alkyl optionally substituted with one or more -F;C1-6 alkyl optionally substituted with one or more substituents independently selected from-Cl, -Br, -OR8e, -SR8e, -N(R8e)2, -NO2, and -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7e; or R4and R4atogether form a C4-10 carbocycle, or 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, or 3- to 10-membered heterocycle, is optionally substituted with one or more substituents independently selected from R7e;R5is selected from: hydrogen, halogen, -OR8f, -SR8f, -N(R8f)2, -NO2, -CN, C1-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C1-6 alkyl, C3-10 carbocycle, and 3- to 10- membered heterocycle are each optionally substituted with one or more substituents independently selected from R7f;R6is selected from: hydrogen; andC1-6 alkyl optionally substituted with one or more substituents independently selected from R7g; each R7, R7a, R7b, R7c, R7d, R7e, R7f, and R7gis independently selected from:hydrogen, halogen, -CN, -OH, -SH, -NO2, -NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, - N(CI-6 alkyl)2, and -NH(CI-6 alkyl); andC1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10- membered heterocycle, and Ci-e haloalkyl; each R8, R8a, R8b, R8c, R8d, R8e, and R8fis independently selected from: hydrogen, halogen, -CN, -OH, -SH, -NO2, -NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, - N(CI-6 alkyl)2, and -NH(CI-6 alkyl); andC1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10- membered heterocycle, and Ci-e haloalkyl.2 A compound represented by Formula (I)or a salt thereof, wherein:X1X2, X3, and X4are independently selected from C(R°) and N; each R° is independently selected from:hydrogen, halogen, -NO2, -CN, -N3, -OR8, -SR8, -N(R8)2, -C(O)R8, -C(O)N(R8)2, -N(R8)C(O)R8, -N(R8)C(O)N(R8)2, -OC(O)N(R8)2, -N(R8)C(O)OR8, -C(O)OR8, - OC(O)R8, -S(O)R8, and -S(O)2R8;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8, -SR8, - N(R8)2, -C(O)R8, -C(O)N(R8)2, -N(R8)C(O)R8, -C(O)OR8, -OC(O)R8, - N(R8)C(O)N(R8)2, -OC(O)N(R8)2, -N(R8)C(O)OR8, -S(O)R8, -S(O)2R8, -NO2, =0, =s, =N(R8), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R7; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8, - SR8, -N(R8)2, -C(O)R8, -C(O)N(R8)2, -N(R8)C(O)R8-N(R8)C(O)N(R8)2, -OC(O)N(R8)2, -N(R8)C(O)OR8, -C(O)OR8, -OC(O)R8, -S(O)R8, -S(O)2R8, -NO2, =0, =S, =N(R8), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R7; ed from: hydrogen;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R8a, -SR8a, - N(R8a)2, -C(0)R8a, -C(O)N(R8a)2, -N(R8a)C(O)R8a, -C(0)0R8a, -0C(0)R8a, - N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, -N(R8a)C(O)OR8a, -S(O)R8a, -S(O)2R8a, -N02, =0, =S, =N(R8a), -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3- 10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7a; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R8a, - SR8a, -N(R8a)2, -C(0)R8a, -C(O)N(R8a)2, -N(R8a)C(O)R8a, -N(R8a)C(O)N(R8a)2, - OC(O)N(R8a)2, -N(R8a)C(O)OR8a, -C(0)0R8a, -0C(0)R8a, -S(O)R8a, -S(O)2R8a, -N02, =0, =S, =N(R8a), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R7a; orR1together with R2form a C3-10 cycloalkyl, C5-10 cycloalkenyl, 3- to 10- membered heterocycloalkyl, or 5- to 10-membered heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8a, -SR8a, -N(R8a)2, -C(O)R8a, -C(O)N(R8a)2, -N(R8a)C(O)R8a, - N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, -N(R8a)C(O)OR8a, -C(O)OR8a, -OC(O)R8a, - S(O)R8a, -S(O)2R8a, -NO2, =0 , =S, =N(R8a), -CN, Ci-6alkyl, C2.6alkenyl, and C2.6alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R7a; ed from: hydrogen;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R8b, -SR8b, - N(R8b)2, -C(0)R8b, -C(O)N(R8b)2, -N(R8b)C(O)R8b-C(0)0R8b, -0C(0)R8b, - N(R8b)C(O)N(R8b)2, -OC(O)N(R8b)2, -N(R8b)C(O)OR8b, -S(O)R8b, -S(O)2R8b, -N02, =0, =S, =N(R8b), -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3- 10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7b; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R8b, - SR8b, -N(R8b)2, -C(0)R8b, -C(O)N(R8b)2, -N(R8b)C(O)R8b-N(R8b)C(O)N(R8b)2, - OC(O)N(R8b)2, -N(R8b)C(O)OR8b, -C(0)0R8b, -0C(0)R8b, -S(O)R8b, -S(O)2R8b, -N02, =0, =S, =N(R8b), -CN, -N3, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7b; orR1together with R2form a C3-10 cycloalkyl, C5-10 cycloalkenyl, 3- to 10- membered heterocycloalkyl, or 5- to 10-membered heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R8a, -SR8a, -N(R8a)2, -C(0)R8a, -C(O)N(R8a)2, -N(R8a)C(O)R8a, - N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, -N(R8a)C(O)OR8a, -C(0)0R8a, -0C(0)R8a, - S(O)R8a, -S(O)2R8a, -N02, =0 , =S, =N(R8a), -CN, Ci-6alkyl, C2.6alkenyl, and C2.6alkynyl, wherein Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R7a; orR2together with R3form a 3- to 15-membered heterocycloalkyl or 5- to 15- membered heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8a, -SR8a, -N(R8a)2, -C(O)R8a, - C(O)N(R8a)2, -N(R8a)C(O)R8a, -N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, - N(R8a)C(O)OR8a, -C(O)OR8a, -OC(O)R8a, -S(O)R8a, -S(O)2R8a, -NO2, =0-, =S, =N(R8a), -CN, Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10- membered heterocycle, are each optionally substituted with one or more substituents independently selected from R713; ed from: hydrogen; andC1-6 alkyl optionally substituted with one or more substituents independently selected from R7c; orR2together with R3form a 3- to 15-membered heterocycloalkyl or 5- to 15- membered heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R8a, -SR8a, -N(R8a)2, -C(0)R8a, - C(O)N(R8a)2, -N(R8a)C(O)R8a, -N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, - N(R8a)C(O)OR8a, -C(0)0R8a, -0C(0)R8a, -S(O)R8a, -S(O)2R8a, -N02, =0-, =S, =N(R8a), -CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10- membered heterocycle, are each optionally substituted with one or more substituents independently selected from R713; ed from:C3-6 alkyl optionally substituted with one or more substituents independently selected from R7d; and-CH2F, -CHF2, and C2-6 alkyl optionally substituted with one or more -F;C1-6 alkyl substituted with one or more substituents independently selected from - Cl, -Br, -0R8d, -SR8d, -N(R8d)2, -N02, and -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7d; or R4and R4atogether form a C4-10 carbocycle, or 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, or 3- to 10-membered heterocycle, is optionally substituted with one or more substituents independently selected from R7e;R4ais selected from: hydrogen, halogen, -OR8e, -SR8e, -N(R8e)2, -NO2, and -CN; and-CH2F, -CHF2, and C2-6 alkyl optionally substituted with one or more -F;C1-6 alkyl optionally substituted with one or more substituents independently selected from -Cl, -Br, -OR8e, -SR8e, -N(R8e)2, -NO2, and -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7e; or R4and R4atogether form a C4-10 carbocycle, or 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, or 3- to 10-membered heterocycle, is optionally substituted with one or more substituents independently selected from R7e;R5is selected from: hydrogen, halogen, -OR8f, -SR8f, -N(R8f)2, -NO2, -CN, C1-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C1-6 alkyl, C3-10 carbocycle, and 3- to 10- membered heterocycle are each optionally substituted with one or more substituents independently selected from R7f;R6is selected from: hydrogen; andC1-6 alkyl optionally substituted with one or more substituents independently selected from R7g; each R7, R7a, R7b, R7c, R7d, R7e, R7f, and R7gis independently selected from: hydrogen, halogen, -CN, -OH, -SH, -NO2, -NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, - N(CI-6 alkyl)2, and -NH(CI-6 alkyl); andC1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10- membered heterocycle, and Ci-e haloalkyl; each R8, R8a, R8b, R8c, R8d, R8e, and R8fis independently selected from:hydrogen, halogen, -CN, -OH, -SH, -NO2, -NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, - N(CI-6 alkyl)2, and -NH(CI-6 alkyl); andC1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10- membered heterocycle, and Ci-e haloalkyl. The compound or salt of claim 1 or claim 2, wherein the compound is not:The compound or salt of any one of claims 1 to 3, wherein the compound or salt is not a compound of List 1, or a salt thereof. The compound or salt of any one of claims 1 to 4, wherein one of X1or X2is N. The compound or salt of any one of claims 1 to 4, wherein X1, X2, X3, and X4are each independently selected from C(R°). The compound or salt of any one of claims 1 to 6, wherein each R° is independently selected from: hydrogen, halogen, -NO2, -CN, -N3, -OR8, -SR8, -N(R8)2, C1-6 alkyl, C1-6 haloalkyl, C3-10 carbocycle and 3- to 10-membered heterocycle. The compound or salt of any one of claims 1 to 7, wherein each R° is independently selected from: hydrogen and fluoro. The compound or salt of any one of claims 1 to 8, wherein R2is selected from: C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R8b, -SR8b, -N(R8b)2, -C(0)R8b, - C(O)N(R8b)2, -N(R8b)C(O)R8b-N(R8b)C(O)N(R8b)2, -OC(O)N(R8b)2, - N(R8b)C(O)OR8b, -C(0)0R8b, -0C(0)R8b, -S(O)R8b, -S(O)2R8b, -N02, =0, =S, =N(R8b), -CN, - N3, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-memberedheterocycle, are each optionally substituted with one or more substituents independently selected from R7b.

10. The compound or salt of any one of claims 1 to 9, wherein R2is selected from: C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8b, -SR8b, -N(R8b)2, -NO2, =0, -CN, C1-6 alkyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C1-6 alkyl, C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R7b.

11. The compound or salt of any one of claims 1 to 10, wherein R2is selected from: C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -O(Ci-6 alkyl), N(CI-6 alkyl)2, C3- 10 carbocycle, 3- to 10-membered heterocycle, -OH, and -CN.

12. The compound or salt of claim 10, wherein R2is selected from:

13. The compound or salt of any one of claims 1 to 12, wherein R4is C1-6 alkyl substituted with one substituent selected from: C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3- 10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted.

14. The compound or salt of any one of claims 1 to 12, wherein R4is selected from: C3-6 alkyl; and Ci alkyl optionally substituted with one or more substituents independently selected from: C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10- membered heterocycle is optionally substituted with one or more substituents independently selected from R7d.

15. The compound or salt of claim 1 or any one of claims 3 to 12, wherein R4is selected from:

16. The compound or salt of claim 1 to 12, wherein R4is selected from: propyl, isopropyl, / / -butyl, ec-butyl, zso-butyl, tert-butyl, benzyl,17. The compound or salt of any one of claims 1 to 12, wherein R4is C1-6 alkyl substituted with one or more substituents independently selected from -Cl, -Br, -CN, -OH, -NH2, =0, -O-C1-6 alkyl, - N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle.

18. The compound or salt of any one of claims 1 to 17, wherein R4ais hydrogen, fluoro, -OH, -CN, or C1-6 alkyl.

19. The compound or salt of any one of claims 1 to 17, wherein R4ais hydrogen.

20. The compound or salt of any one of claims 1 to 17, wherein R4and R4atogether form a C4-6 carbocycle, or 3- to 6-membered heterocycle, each of which is optionally substituted.

21. The compound or salt of any one of claims 1 to 7 or any one of claims 13 to 20, wherein R2together with R3form an optionally substituted 3- to 15-membered heterocycle.

22. The compound or salt of any one of claims 1 to 7 or any one of claims 13 to 21, wherein R2together with R3form an optionally substituted bridged 3- to 15-membered heterocycle.

23. The compound or salt of any one of claims 1 to 7 or any one of claims 13 to 22, wherein R2O together with R3form a heterocycle selected from: ' that is optionally substituted.

24. The compound or salt of claim 1 to 23, wherein R5is selected from hydrogen, halogen, -OR8f, - N(R8f)2, C1-6 alkyl.

25. The compound or salt of claim 1 to 24, wherein R5is selected from hydrogen, -OH, -OMe, -F, and -CH3.

26. The compound or salt of claim 1 to 25, wherein R3is selected from hydrogen and C1-6 alkyl.

27. The compound or salt of claim 1 to 26, wherein R3is selected from hydrogen.

28. The compound or salt of claim 1 to 27, wherein R6is selected from hydrogen and C1-6 alkyl.

29. The compound or salt of claim 1 to 28, wherein R6is selected from hydrogen.

30. The compound or salt of claim 1, selected from:

31. A compound represented by Formula (II)or a salt thereof, wherein:X11, X12, X13, and X14are independently selected from C(R10), and N; each R10is independently selected from: hydrogen, halogen, -NO2, -CN, -N3, -OR18, -SR18, -N(R18)2, -C(O)R18, - C(O)N(R18)2, -N(R18)C(O)R18, -N(R18)C(O)N(R18)2, -OC(O)N(R18)2, - N(R18)C(O)OR18, -C(O)OR18, -OC(O)R18, -S(O)R18, and -S(O)2R18;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR18, -SR18, -N(R18)2, -C(O)R18, -C(O)N(R18)2, -N(R18)C(O)R18-C(O)OR18, -OC(O)R18, - N(R18)C(O)N(R18)2, -OC(O)N(R18)2, -N(R18)C(O)OR18, -S(O)R18, -S(O)2R18, -NO2, =0, =S, =N(R18), -CN, C3-io carbocycle and 3- to 10-membered heterocycle, wherein the C3. io carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R17; andC3-io carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR18, - SR18, -N(R18)2, -C(O)R18, -C(O)N(R18)2, -N(R18)C(O)R18, -N(R18)C(O)N(R18)2, - OC(O)N(R18)2, -N(R18)C(O)OR18, -C(O)OR18, -OC(O)R18, -S(O)R18, -S(O)2R18, -NO2, =0, =S, =N(R18), -CN, Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R17; ted from: hydrogen;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR18a, -SR18a, - N(R18a)2, -C(O)R18a, -C(O)N(R18a)2, -N(R18a)C(O)R18a, -C(O)OR18a, -OC(O)R18a, - N(R18a)C(O)N(R18a)2, -OC(O)N(R18a)2, -N(R18a)C(O)OR18a, -S(O)R18a, -S(O)2R18a, -NO2, =0, =S, =N(R18a), -CN, C3-io carbocycle, and 3- to 10-membered heterocycle, wherein the C3-io carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17a; andC3-io carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR18a, - SR18a, -N(R18a)2, -C(O)R18a, -C(O)N(R18a)2, -N(R18a)C(O)R18a, -N(R18a)C(O)N(R18a)2, - OC(O)N(R18a)2, -N(R18a)C(O)OR18a, -C(O)OR18a, -OC(O)R18a, -S(O)R18a, -S(O)2R18a, - NO2, =0, =S, =N(R18a), -CN, Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R17a; orR11together with R12form a C3-io cycloalkyl, C5-10 cycloalkenyl, 3- to 10- membered heterocycloalkyl, or 5- to 10-membered heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR18a, -SR18a, -N(R18a)2, -C(0)R18a, -C(O)N(R18a)2, -N(R18a)C(O)R18a, - N(R18a)C(O)N(R18a)2, -OC(O)N(R18a)2, -N(R18a)C(O)OR18a, -C(0)0R18a, -0C(0)R18a, - S(O)R18a, -S(O)2R18a, -NO2, =0 , =S, =N(R18a), -CN, Ci-6alkyl, C2.6alkenyl, and C2.6alkynyl, wherein Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R17a;R12is selected from: hydrogen;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR18b, -SR18b, - N(R18b)2, -C(O)R18b, -C(O)N(R18b)2, -N(R18b)C(O)R18b-C(O)OR18b, -OC(O)R18b, - N(R18b)C(O)N(R18b)2, -OC(O)N(R18b)2, -N(R18b)C(O)OR18b, -S(O)R18b, -S(O)2R18b, - NO2, =0, =S, =N(R18b), -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17b; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR18b, - SR18b, -N(R18b)2, -C(O)R18b, -C(O)N(R18b)2, -N(R18b)C(O)R18b-N(R18b)C(O)N(R18b)2, - OC(O)N(R18b)2, -N(R18b)C(O)OR18b, -C(O)OR18b, -OC(O)R18b, -S(O)R18b, -S(O)2R18b, - NO2, =0, =S, =N(R18b), -CN, -N3, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17b; orR11together with R12form a C3-10 cycloalkyl, C3-10 cycloalkenyl, 3- to 10- membered heterocycloalkyl, or 3- to 10-membered heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R18a, -SR18a, -N(R18a)2, -C(0)R18a, -C(O)N(R18a)2, -N(R18a)C(O)R18a, - N(R18a)C(O)N(R18a)2, -OC(O)N(R18a)2, -N(R18a)C(O)OR18a, -C(0)0R18a, -0C(0)R18a, - S(O)R18a, -S(O)2R18a, -NO2, =0 , =S, =N(R18a), -CN, Ci-6alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents; orR12together with R13form a 3- to 15-membered heterocycloalkyl or 5- to 15- membered heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R8a, -SR8a, -N(R8a)2, -C(0)R8a, - C(O)N(R8a)2, -N(R8a)C(O)R8a, -N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, - N(R8a)C(O)OR8a, -C(0)0R8a, -0C(0)R8a, -S(O)R8a, -S(O)2R8a, -N02, =0-, =S, =N(R8a), -CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R17b;R13is selected from: hydrogen; andCi-6 alkyl optionally substituted with one or more substituents independently selected from R17c; orR12together with R13form a 3- to 15-membered heterocycloalkyl or 5- to 15- membered heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8a, -SR8a, -N(R8a)2, -C(O)R8a, - C(O)N(R8a)2, -N(R8a)C(O)R8a, -N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, - N(R8a)C(O)OR8a, -C(O)OR8a, -OC(O)R8a, -S(O)R8a, -S(O)2R8a, -NO2, =0-, =S, =N(R8a), -CN, Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10- membered heterocycle are each optionally substituted with one or more substituents independently selected from R17b;R14is selected from: hydrogen; andC1-6 alkyl substituted with one or more substituents independently selected from halogen, -OR18d, -SR18d, -N(R18d)2, -NO2, and -CN, C3-10 carbocycle, and 3- to 10- membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17d; or R4and R4atogether form a C3-10 carbocycle, or 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, or 3- to 10-membered heterocycle, is optionally substituted with one or more substituents independently selected from R17d; R14ais selected from: hydrogen; andC1-6 alkyl substituted with one or more substituents independently selected from halogen, -OR18d, -SR18d, -N(R18d)2, -NO2, and -CN, C3-10 carbocycle, and 3- to 10- membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17d; andor R4and R4atogether form a C3-10 carbocycle, or 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, or 3- to 10-membered heterocycle, is optionally substituted with one or more substituents independently selected from R17d;R15is selected from:C4-6 alkyl, C3 heterocycloalkyl, and 4- to 10-membered heterocycle, wherein the C4-6 alkyl, C3 heterocycloalkyl, and 4- to 10- membered heterocycle are each optionally substituted with one or more substituents independently selected from R17e; 16is selected from: hydrogen; andC1-6 alkyl optionally substituted with one or more substituents independently selected from R17f; each R17, R17a, R17b, R17c, R17d, R17e, and R17fis independently selected from: hydrogen, halogen, -CN, -OH, -SH, -NO2, -NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, - N(CI-6 alkyl)2, and -NH(CI-6 alkyl); andC1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10- membered heterocycle, and Ci-e haloalkyl; each R18, R18a, R18b, R18c, and R18dis independently selected from: hydrogen, halogen, -CN, -OH, -SH, -NO2, -NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, - N(CI-6 alkyl)2, and -NH(CI-6 alkyl); andC1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10- membered heterocycle, and Ci-e haloalkyl.

32. The compound or salt of claim 31, wherein R12is selected from:C3-6 carbocycle, and 3- to 6-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -NH2, =0, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10- membered heterocycle.

33. The compound or salt of claim 32, wherein34. The compound or salt of any one of claims 31 to 33, wherein R15is selected from:C3-6 heterocycloalkyl and 4- to 6-membered heterocycle, wherein the C3-6 heterocycloalkyl and 4- to 6-membered heterocycle are each optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -NH2, =0, - C(O)Ci-6alkyl, -N(0)CI-6alkyl, -O-C1-6 alkyl, -N(CI-6alkyl)2, and -NH(CI-6alkyl).

35. The compound or salt of any one of claims 31 to 34, wherein R15is selected from:

36. The compound or salt of claim 31, selected from:

37. A compound represented by Formula (III)or a salt thereof, wherein: n is independently selected from: 0, 1, and 2; each R20is independently selected from: hydrogen;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR28, -SR28, - N(R28)2, -C(O)R28, -C(O)N(R28)2, -N(R28)C(O)R28-C(O)OR28, -OC(O)R28, - N(R28)C(O)N(R28)2, -OC(O)N(R28)2, -N(R28)C(O)OR28, -S(O)R28, -S(O)2R28, -NO2, =0, =S, =N(R28), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3- 10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R27; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR28, - SR28, -N(R28)2, -C(O)R28, -C(O)N(R28)2, -N(R28)C(O)R28, -N(R28)C(O)N(R28)2, - OC(O)N(R28)2, -N(R28)C(O)OR28, -C(O)OR28, -OC(O)R28, -S(O)R28, -S(O)2R28, -NO2, =0, =S, =N(R28), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R27; 21is selected from: hydrogen;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR28a, -SR28a, - N(R28a)2, -C(O)R28a, -C(O)N(R28a)2, -N(R28a)C(O)R28a, -C(O)OR28a, -OC(O)R28a, - N(R28a)C(O)N(R28a)2, -OC(O)N(R28a)2, -N(R28a)C(O)OR28a, -S(O)R28a, -S(O)2R28a, -NO2, =0, =S, =N(R28a), -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R27a; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR28a, -SR28a, -N(R28a)2, -C(O)R28a, -C(O)N(R28a)2, -N(R28a)C(O)R28a, -N(R28a)C(O)N(R28a)2, - OC(O)N(R28a)2, -N(R28a)C(O)OR28a, -C(O)OR28a, -OC(O)R28a, -S(O)R28a, -S(O)2R28a, - NO2, =0, =S, =N(R28a), -CN, Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R27a; orR21together with R22form a C3-10 cycloalkyl, C5-10 cycloalkenyl, 3- to 10- membered heterocycloalkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR28a, -SR28a, -N(R28a)2, -C(O)R28a, - C(O)N(R28a)2, -N(R28a)C(O)R28a, -N(R28a)C(O)N(R28a)2, -OC(O)N(R28a)2, - N(R28a)C(O)OR28a, -OC(O)R28a, -S(O)R28a, -S(O)2R28a, -NO2, =0 , =S, =N(R28a), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R27a; ted from: hydrogen;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR28b, -SR28b, - N(R28b)2, -C(O)R28b, -C(O)N(R28b)2, -N(R28b)C(O)R28b-C(O)OR28b, -OC(O)R28b, - N(R28b)C(O)N(R28b)2, -OC(O)N(R28b)2, -N(R28b)C(O)OR28b, -S(O)R28b, -S(O)2R28b, - N02, =0, =S, =N(R28b), -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R27b; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR28b, - SR28b, -N(R28b)2, -C(O)R28b, -C(O)N(R28b)2, -N(R28b)C(O)R28b-N(R28b)C(O)N(R28b)2, - OC(O)N(R28b)2, -N(R28b)C(O)OR28b, -C(O)OR28b, -OC(O)R28b, -S(O)R28b, -S(O)2R28b, - N02, =0, =S, =N(R28b), -CN, -N3, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R27b; orR21together with R22form a C3-10 cycloalkyl, C5-10 cycloalkenyl, 3- to 10- membered heterocycloalkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR28a, -SR28a, -N(R28a)2, -C(O)R28a, - C(O)N(R28a)2, -N(R28a)C(O)R28a, -N(R28a)C(O)N(R28a)2, -OC(O)N(R28a)2, - N(R28a)C(O)OR28a, -OC(O)R28a, -S(O)R28a, -S(O)2R28a, -N02, =0 , =S, =N(R28a), -CN,Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R27a; orR22together with R23form a 3- to 15-membered heterocycloalkyl or 5- to 15- membered heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR28a, -SR28a, -N(R28a)2, -C(O)R28a, - C(O)N(R28a)2, -N(R28a)C(O)R28a, -N(R28a)C(O)N(R28a)2, -OC(O)N(R28a)2, - N(R28a)C(O)OR28a, -C(O)OR28a, -OC(O)R28a, -S(O)R28a, -S(O)2R28a, -NO2, =0-, =S, =N(R28a), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R27b; ted from: hydrogen; andC1-6 alkyl optionally substituted with one or more substituents independently selected from R27c; orR22together with R23form a 3- to 15-membered heterocycloalkyl or 5- to 15- membered heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR28a, -SR28a, -N(R28a)2, -C(O)R28a, - C(O)N(R28a)2, -N(R28a)C(O)R28a, -N(R28a)C(O)N(R28a)2, -OC(O)N(R28a)2, - N(R28a)C(O)OR28a, -C(O)OR28a, -OC(O)R28a, -S(O)R28a, -S(O)2R28a, -N02, =0-, =S, =N(R28a), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R27b; endently selected from: hydrogen, halogen, -OR28d, -SR28d, -N(R28d)2, -NO2, and -CN; andC1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR28d, -SR28d, -N(R28d)2, -NO2, and -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more R27d; orR24together with R24aform a C3-10 carbocycle, or 3- to 10-membered heterocycloalkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR28e, -SR28e, -N(R28e)2, -C(O)R28e, - C(O)N(R28e)2, -N(R28e)C(O)R28e, -N(R28e)C(O)N(R28e)2, -OC(O)N(R28e)2, - N(R28e)C(O)OR28e, -C(O)OR28e, -OC(O)R28e, -S(O)R28e, -S(O)2R28e, -N02, =0-, =S,=N(R28e), -CN, Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R27e;R24ais independently selected from: hydrogen, halogen, -OR28e, -SR28e, -N(R28e)2, -NO2, and -CN; andC1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR28e, -SR28e, -N(R28e)2, -NO2, and -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more R27e; orR24together with R24aform a C3-10 carbocycle, or 3- to 10-membered heterocycloalkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR28e, -SR28e, -N(R28e)2, -C(O)R28e, - C(O)N(R28e)2, -N(R28e)C(O)R28e, -N(R28e)C(O)N(R28e)2, -OC(O)N(R28e)2, - N(R28e)C(O)OR28e, -C(O)OR28e, -OC(O)R28e, -S(O)R28e, -S(O)2R28e, -NO2, =0-, =S, =N(R28e), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R27e;R25is selected from: hydrogen, halogen, -OR28f, -SR28f, -N(R28f)2, -NO2, and -CN;Ci alkyl, optionally substituted with one or more substituents independently selected from -OH, -Cl, -Br, -CN, -OH, -SH, -N02, -NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, - N(CI-6 alkyl)2, and -NH(CI-6 alkyl), and C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-e haloalkyl; andC2-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C2-6 alkyl, C3-10 carbocycle, and 3- to 10- membered heterocycle are each optionally substituted with one or more substituents independently selected from R27f;R26is selected from: hydrogen; andC1-6 alkyl optionally substituted with one or more substituents independently selected from R27g; each R27, R27a, R27b, R27c, R27d, R27e, R27f, R27gis independently selected from:hydrogen, halogen, -CN, -OH, -SH, -NO2, -NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, - N(CI-6 alkyl)2, and -NH(CI-6 alkyl); andC1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10- membered heterocycle, and Ci-e haloalkyl; each R28, R28a, R28b, R28c, R28d, R28e, and R28fis independently selected from: hydrogen, halogen, -CN, -OH, -SH, -NO2, -NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, - N(CI-6 alkyl)2, and -NH(CI-6 alkyl); andC1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10- membered heterocycle, and Ci-e haloalkyl.

38. The compound or salt of claim 37, wherein each R20is independently selected from: hydrogen; C1-6 alkyl; C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle, optionally substituted with one or more substituents independently selected from halogen, -OR28, -SR28, - N(R28)2, -C(O)R28, -C(O)N(R28)2, -N(R28)C(O)R28-N(R28)C(O)N(R28)2, -OC(O)N(R28)2, - N(R28)C(O)OR28, -C(O)OR28, -OC(O)R28, -NO2, =0, =S, =N(R28), -CN, and Ci-6alkyl.

39. The compound or salt of claim 37, wherein R22is selected from:C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -NH2, =0, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10- membered heterocycle.

40. The compound or salt of claim 38, wherein R22is selected from:

41. The compound or salt of any one of claims 37 to 40, wherein n is 0.

42. The compound or salt of any one of claims 37 to 41, wherein n is 1.

43. The compound or salt of claim 37, selected from:

44. A compound represented by Formula (IV)or a salt thereof, wherein:X31, X32, X33, and X34are independently selected from C(R30) and N;Y is independently selected from O, N(R30a), and N-O(R30b); ing A is independently selected from:C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR38, - SR38, -N(R38)2, -C(O)R38, -C(O)N(R38)2, -N(R38)C(O)R38, -N(R38)C(O)N(R38)2, - OC(O)N(R38)2, -N(R38)C(O)OR38, -C(O)OR38, -OC(O)R38, -S(O)R38, -S(O)2R38, -NO2, =0, =S, =N(R38), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R37; orRing A is absent;each R30, R30a, and R30bis independently selected from: hydrogen, halogen, -NO2, -CN, -N3, -OR38, -SR38, -N(R38)2, -C(O)R38, - C(O)N(R38)2, -N(R38)C(O)R38, -N(R38)C(O)N(R38)2, -OC(O)N(R38)2, - N(R38)C(O)OR38, -C(O)OR38, -OC(O)R38, -S(O)R38, and -S(O)2R38;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR38, -SR38, - N(R38)2, -C(O)R38, -C(O)N(R38)2, -N(R38)C(O)R38-C(O)OR38, -OC(O)R38, - N(R38)C(O)N(R38)2, -OC(O)N(R38)2, -N(R38)C(O)OR38, -S(O)R38, -S(O)2R38, -NO2, =0, =S, =N(R38), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3- 10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R37; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR38, - SR38, -N(R38)2, -C(O)R38, -C(O)N(R38)2, -N(R38)C(O)R38, -N(R38)C(O)N(R38)2, - OC(O)N(R38)2, -N(R38)C(O)OR38, -C(O)OR38, -OC(O)R38, -S(O)R38, -S(O)2R38, -NO2, =0, =S, =N(R38), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R37;31is selected from: hydrogen;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR38a, -SR38a, - N(R38a)2, -C(O)R38a, -C(O)N(R38a)2, -N(R38a)C(O)R38a, -C(O)OR38a, -OC(O)R38a, - N(R38a)C(O)N(R38a)2, -OC(O)N(R38a)2, -N(R38a)C(O)OR38a, -S(O)R38a, -S(O)2R38a, -N02, =0, =S, =N(R38a), -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R37a; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR38a, - SR38a, -N(R38a)2, -C(O)R38a, -C(O)N(R38a)2, -N(R38a)C(O)R38a, -N(R38a)C(O)N(R38a)2, - OC(O)N(R38a)2, -N(R38a)C(O)OR38a, -C(O)OR38a, -OC(O)R38a, -S(O)R38a, -S(O)2R38a, - N02, =0, =S, =N(R38a), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R37a; orR31together with R32form a C3-10 cycloalkyl, C5-10 cycloalkenyl, 3- to 10- membered heterocycloalkyl, or 5- to 10-membered heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR38a, -SR38a, -N(R38a)2, -C(O)R38a, -C(O)N(R38a)2, -N(R38a)C(O)R38a, - N(R38a)C(O)N(R38a)2, -OC(O)N(R38a)2, -N(R38a)C(O)OR38a, -C(O)OR38a, -OC(O)R38a, - S(O)R38a, -S(O)2R38a, -NO2, =0 , =S, =N(R38a), -CN, Ci-6alkyl, C2.6alkenyl, and C2.6alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R37a; ted from: hydrogen;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR38b, -SR38b, - N(R38b)2, -C(O)R38b, -C(O)N(R38b)2, -N(R38b)C(O)R38b-C(O)OR38b, -OC(O)R38b, - N(R38b)C(O)N(R38b)2, -OC(O)N(R38b)2, -N(R38b)C(O)OR38b, -S(O)R38b, -S(O)2R38b, - N02, =0, =S, =N(R38b), -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R37b; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR38b, - SR38b, -N(R38b)2, -C(O)R38b, -C(O)N(R38b)2, -N(R38b)C(O)R38b-N(R38b)C(O)N(R38b)2, - OC(O)N(R38b)2, -N(R38b)C(O)OR38b, -C(O)OR38b, -OC(O)R38b, -S(O)R38b, -S(O)2R38b, - N02, =0, =S, =N(R38b), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R37b; orR31together with R32form a C3-10 cycloalkyl, C5-10 cycloalkenyl, 3- to 10- membered heterocycloalkyl, or 5- to 10-membered heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR38a, -SR38a, -N(R38a)2, -C(O)R38a, -C(O)N(R38a)2, -N(R38a)C(O)R38a, - N(R38a)C(O)N(R38a)2, -OC(O)N(R38a)2, -N(R38a)C(O)OR38a, -C(O)OR38a, -OC(O)R38a, - S(O)R38a, -S(O)2R38a, -N02, =0 , =S, =N(R38a), -CN, Ci-6alkyl, C2.6alkenyl, and C2.6alkynyl, wherein Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R37a; ted from: hydrogen;and Ci-6 alkyl optionally substituted with one or more R37c;R34is independently selected from: hydrogen, halogen, -OR38c, -SR38c, -N(R38c)2, -NO2, and -CN; andC1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR38c, -SR38c, -N(R38c)2, -NO2, and -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more R37d; orR34together with R34aform a C3-10 carbocycle, or 3- to 10-membered heterocycloalkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR38d, -SR38d, -N(R38d)2, -C(O)R38d, - C(O)N(R38d)2, -N(R38d)C(O)R38d-N(R38d)C(O)N(R38d)2, -OC(O)N(R38d)2, - N(R38d)C(O)OR38d, -C(O)OR38d, -OC(O)R38d, -S(O)R38d, -S(O)2R38d, -NO2, =0-, =S, =N(R38d), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R37e;R34ais independently selected from: hydrogen, halogen, -OR38d, -SR38d, -N(R38d)2, -NO2, and -CN; andC1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR38d, -SR38d, -N(R38d)2, -NO2, and -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more R37e; orR34together with R34aform a C3-10 carbocycle, or 3- to 10-membered heterocycloalkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR38d, -SR38d, -N(R38d)2, -C(O)R38d, - C(O)N(R38d)2, -N(R38d)C(O)R38d-N(R38d)C(O)N(R38d)2, -OC(O)N(R38d)2, - N(R38d)C(O)OR38d, -C(O)OR38d, -OC(O)R38d, -S(O)R38d, -S(O)2R38d, -N02, =0-, =S, =N(R38d), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R37e;R35is independently selected from: hydrogen, halogen, -OR38e, -SR38e, -N(R38e)2, -N02, -CN, Ci-6alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C1-6 alkyl, C3-10 carbocycle, and 3- to 10- membered heterocycle are each optionally substituted with one or more R37f; orR36is independently selected from: hydrogen;and Ci-6 alkyl optionally substituted with one or more R37g; each R37, R37a, R37b, R37c, R37d, R37e, R37f, and R37gis independently selected from: hydrogen, halogen, -CN, -OH, -SH, -NO2, -NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, - N(CI-6 alkyl)2, and -NH(CI-6 alkyl); andC1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10- membered heterocycle, and Ci-e haloalkyl; each R38, R38a, R38b, R38c, R38d, and R38eis independently selected from: hydrogen, halogen, -CN, -OH, -SH, -NO2, -NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, - N(CI-6 alkyl)2, and -NH(CI-6 alkyl); andC1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10- membered heterocycle, and Ci-e haloalkyl.

45. The compound or salt of claim 27, wherein Y is N(R30a).

46. The compound or salt of claim 28, wherein Y is NH.

47. The compound or salt of claim 26, wherein Ring A is absent.

48. The compound or salt of claim 26, wherein Ring A is selected from C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-Ci- 6 alkyl, -SO2-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl.

49. The compound or salt of claim 26, wherein Ring A is50. The compound or salt of any one of claims 26 to 32, wherein Y is O.

51. The compound or salt of any one of claims 26 to 32, wherein Y is NH.

52. The compound or salt of claim 27, selected from:

53. A compound represented by Formula (V)or a salt thereof, wherein:X1is independently selected from C(ROa), N, and N+(-O );X2is independently selected from C(Rob), N, and N+(-O );X3is independently selected from C(ROc), N, and N+(-O );X4is independently selected from C(Rod), N, and N+(-O ); herein no more than three of X1, X2, X3, and X4are C(H); y is selected from: 3- to 20-membered heterocycle, optionally substituted with one or more substituents independently selected from: halogen, -OR8a, -SR8a, -N(R8a)2, -C(O)R8a, -C(O)N(R8a)2, -N(R8a)C(O)R8a, -N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, -N(R8a)C(O)OR8a, -C(O)OR8a, -OC(O)R8a, -S(O)R8a, -S(O)2R8a, -NO2, =0, =S, =N(R8a), -CN;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R7a; andC3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from: halogen, -OR8a, -SR8a, -N(R8a)2, -C(O)R8a, -C(O)N(R8a)2, -N(R8a)C(O)R8a, - N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, -N(R8a)C(O)OR8a, -C(O)OR8a, - OC(O)R8a, -S(O)R8a, -S(O)2R8a, -NO2, =0, =S, =N(R8a), -CN;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R7a; andC3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R7a;Oais independently selected from: hydrogen, halogen, -NO2, -CN, -N3, -OR8, -SR8, -N(R8)2, -C(O)R8, -C(O)N(R8)2, -N(R8)C(O)R8, -N(R8)C(O)N(R8)2, -OC(O)N(R8)2, -N(R8)C(O)OR8, -C(O)OR8, -OC(O)R8, -S(O)R8, and -S(O)2R8;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8, -SR8, -N(R8)2, -C(O)R8, - C(O)N(R8)2, -N(R8)C(O)R8, -C(O)OR8, -OC(O)R8, -N(R8)C(O)N(R8)2, -OC(O)N(R8)2, - N(R8)C(O)OR8, -S(O)R8, -S(O)2R8, -NO2, =0, =S, =N(R8), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R7; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8, -SR8, - N(R8)2, -C(0)R8, -C(O)N(R8)2, -N(R8)C(O)R8, -N(R8)C(O)N(R8)2, -OC(O)N(R8)2, - N(R8)C(O)OR8, -C(0)0R8, -0C(0)R8, -S(O)R8, -S(O)2R8, -N02, =0, =S, =N(R8), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R7;obis independently selected from: hydrogen, halogen, -N02, -CN, -N3, -OR8, -SR8, -N(R8)2, -C(0)R8, -C(O)N(R8)2, -N(R8)C(O)R8, -N(R8)C(O)N(R8)2, -OC(O)N(R8)2, -N(R8)C(O)OR8, -C(0)0R8, -0C(0)R8, -S(O)R8, and -S(O)2R8;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8, -SR8, -N(R8)2, -C(O)R8, - C(O)N(R8)2, -N(R8)C(O)R8;-C(O)OR8, -OC(O)R8, -N(R8)C(O)N(R8)2, -OC(O)N(R8)2, - N(R8)C(O)OR8, -S(O)R8, -S(O)2R8, -NO2, =0, =S, =N(R8), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R7; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8, -SR8, - N(R8)2, -C(0)R8, -C(O)N(R8)2, -N(R8)C(O)R8, -N(R8)C(O)N(R8)2, -OC(O)N(R8)2, - N(R8)C(O)OR8, -C(0)0R8, -0C(0)R8, -S(O)R8, -S(O)2R8, -NO2, =0, =S, =N(R8), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R7;Ocis independently selected from: hydrogen, halogen, -NO2, -CN, -N3, -OH, -0(Ci-6 haloalkyl), -SR8, -N(R8)2, -C(0)R8, - C(O)N(R8)2, -N(R8)C(O)R8, -N(R8)C(O)N(R8)2, -OC(O)N(R8)2, - N(R8)C(O)OR8, -C(0)0R8, -0C(0)R8, -S(O)R8, and -S(O)2R8;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8, -SR8, -N(R8)2, -C(0)R8, - C(O)N(R8)2, -N(R8)C(O)R8;-C(O)OR8, -0C(0)R8, -N(R8)C(O)N(R8)2, -OC(O)N(R8)2, - N(R8)C(O)OR8, -S(O)R8, -S(O)2R8, -NO2, =0, =S, =N(R8), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R7; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8, -SR8, - N(R8)2, -C(0)R8, -C(O)N(R8)2, -N(R8)C(O)R8, -N(R8)C(O)N(R8)2, -OC(O)N(R8)2, - N(R8)C(O)OR8, -C(0)0R8, -0C(0)R8, -S(O)R8, -S(O)2R8, -NO2, =0, =S, =N(R8), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R7;odis independently selected from:hydrogen, halogen, -NO2, -CN, -N3, -OR8, -SR8, -N(R8)2, -C(O)R8, -C(O)N(R8)2, -N(R8)C(O)R8, -N(R8)C(O)N(R8)2, -OC(O)N(R8)2, -N(R8)C(O)OR8, -C(O)OR8, -OC(O)R8, -S(O)R8, and -S(O)2R8;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8, -SR8, -N(R8)2, -C(O)R8, - C(O)N(R8)2, -N(R8)C(O)R8, -C(O)OR8, -OC(O)R8, -N(R8)C(O)N(R8)2, -OC(O)N(R8)2, - N(R8)C(O)OR8, -S(O)R8, -S(O)2R8, -NO2, =0, =S, =N(R8), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R7; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8, -SR8, - N(R8)2, -C(0)R8, -C(O)N(R8)2, -N(R8)C(O)R8, -N(R8)C(O)N(R8)2, -OC(O)N(R8)2, - N(R8)C(O)OR8, -C(0)0R8, -0C(0)R8, -S(O)R8, -S(O)2R8, -N02, =0, =S, =N(R8), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R7; is selected from: hydrogen, halogen, -0R8d, -SR8d, -N(R8d)2, -N02, and -CN; andC1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -0R8d, -SR8d, -N(R8d)2, -N02, and -CN, C3-10 carbocycle, and 3- to 10- membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7d; orR4and R4atogether form a C4-10 carbocycle, or 3- to 10-membered heterocycle, wherein the C3- 10 carbocycle, or 3- to 10-membered heterocycle, is optionally substituted with one or more substituents independently selected from R7e;ais selected from: hydrogen, halogen, -0R8e, -SR8e, -N(R8e)2, -N02, and -CN; andC1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -0R8e, -SR8e, -N(R8e)2, -N02, and -CN, C3-10 carbocycle, and 3- to 10- membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7e; orR4and R4atogether form a C4-10 carbocycle, or 3- to 10-membered heterocycle, wherein the C3- 10 carbocycle, or 3- to 10-membered heterocycle, is optionally substituted with one or more substituents independently selected from R7e;R5is selected from: hydrogen, halogen, -OR8f, -SR8f, -N(R8f)2, -NO2, -CN, C1-6 alkyl, C3-10 carbocycle, and 3- to 10- membered heterocycle, wherein the C1-6 alkyl, C3-10 carbocycle, and 3- to 10- membered heterocycle are each optionally substituted with one or more substituents independently selected from R7f; 6 is selected from: hydrogen; andC1-6 alkyl optionally substituted with one or more substituents independently selected from R7g; each R7, R7a, R7b, R7c, R7d, R7e, R7f, and R7gis independently selected from: halogen, -CN, -OH, -SH, -NO2, -NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, and -NH(CI-6alkyl); andC1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, - NH(CI-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-e haloalkyl; each R8, R8a, R8b, R8c, R8d, R8e, and R8fis independently selected from: hydrogen; andC1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, - NH(CI-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-e haloalkyl.

54. The compound or salt of claim 53, wherein X1is C(ROa); X2is C(Rob); X3is C(ROc); and X4is C(Rod).

55. The compound or salt of claim 53 or 54 , wherein X3is C(H), and X4is C(H).

56. The compound or salt of any one of claims 53 to 55, wherein X1is C(F) or C(H); X2is C(F); X3is C(H); and X4is C(H).

57. The compound or salt of claim 53 to 56, wherein ROa, Rob, ROc, and Rodare each independently selected from: hydrogen, halogen, -NO2, -CN, -SR8, and -N(R8)2;C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR8, -SR8, -N(R8)2, =0, and -CN.

58. The compound or salt of any one of claims 53 to 57, wherein ROa, Rob, ROc, and Rodare each independently selected from: hydrogen and fluoro.

59. The compound or salt of any one of claims 53 to 58, wherein R4is selected from: hydrogen, halogen, and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen and C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3- 10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R7d.

60. The compound or salt of any one of claims 53 to 59, wherein R4is selected from: hydrogen.

61. The compound or salt of any one of claims 53 to 60, wherein R4ais hydrogen.

62. The compound or salt of any one of claims 53 to 61, wherein R4and R4atogether form a C4-6 carbocycle, or 3- to 6-membered heterocycle.

63. The compound or salt of any one of claims 53 to 62, wherein R5is selected from hydrogen, - OR8f, and -CH3.

64. The compound or salt of any one of claims 53 to 63, wherein R6is selected from hydrogen.

65. The compound or salt of any one of claims 53 to 64, wherein each R7, R7a, R713, R7c, R7d, R7e, R7f, and R7gis independently selected from: halogen, -CN, -OH, -SH, -NO2, -NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, and -NH(CI-6 alkyl), C1-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle.

66. The compound or salt of any one of claims 53 to 65, wherein each R7, R7a, R713, R7c, R7d, R7e, R7f, and R7gis independently selected from: halogen, -CN, -OH, -NH2, and -CH3.

67. The compound or salt of any one of claims 53 to 66, wherein each R8, R8a, R8b, R8c, R8d, R8e, and R8fis independently selected from: hydrogen, C1-6 alkyl, C3-10 carbocycle, and 3- to 10- membered heterocycle.

68. The compound or salt of any one of claims 53 to 67, wherein each R8, R8a, R8b, R8c, R8d, R8e, and R8fis independently selected from: hydrogen and Ci alkyl.

69. The compound or salt of any one of claims 53 to 68, wherein Hy is a 3- to 20-membered heterocycle, optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(Ci-6haloalkyl), -NH2, -NH(CI-6alkyl), -N(CI-6alkyl)2, =0, -CN, -CH3, and -CF3;Ci-6 alkyl, wherein each Ci-6 alkyl is optionally substituted with one or more substituents independently selected from halogen, -OH, -0(CH3), -0(Ci-6 haloalkyl), -NH2, - NH(CI-6 alkyl), -N(CI-6 alkyl)2, =0, -CN, -CH3, -CF3, 3- to 10-membered carbocycle; andC3-io carbocycle and 3- to 10-membered heterocycle, wherein each C3-io carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from: halogen, -OH, -0(CH3), -0(Ci-6 haloalkyl), -NH2, - NH(CI-6 alkyl), -N(CI-6 alkyl)2, =0, -CN, -CH3, -CF3, and 3- to 10-membered heterocycle.

70. The compound or salt of any one of claims 53 to 69, wherein Hy is a 3- to 20-membered heterocycle, optionally substituted with one or more substituents independently selected from: halogen, -OH, -0(CH3), -O(Ci-6haloalkyl), -NH2, -NH(CI-6alkyl), -N(CI-6alkyl)2, =0, -CN, -CH3, and -CF3;Ci-6 alkyl, wherein each Ci-6 alkyl is optionally substituted with one or more substituents independently selected from halogen, -OH, -0(CH3), -0(Ci-6 haloalkyl), -NH2, - NH(CI-6 alkyl), -N(CI-6 alkyl)2, =0, -CN, -CH3, -CF3, and 3- to 10-membered carbocycle; andC3-io carbocycle and 3- to 10-membered heterocycle, wherein each C3-io carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from: halogen, -OH, -0(CH3), -0(Ci-6 haloalkyl), -NH2, - NH(CI-6 alkyl), -N(CI-6 alkyl)2, =0, -CN, -CH3, -CF3, and 3- to 10-membered heterocycle.

71. The compound or salt of any one of claims 53 to 70, wherein Hy is a 3- to 20-membered heterocycle, optionally substituted with one or more substituents independently selected from: halogen, -OH, -0(CH3), -NH2, -NH(CI-6alkyl), -N(CI-6alkyl)2, -SH, -S(CH3), =0, and -CN; C3-io carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -0(CH3), -O(Ci-6haloalkyl), -NH2, -NH(CI-6alkyl), -N(CI-6alkyl)2, =0, -CN, -CH3, -CF3, C3.10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from: halogen, -OH, -0(CH , -O(Ci-6 haloalkyl), -NH2, -NH(CI-6alkyl), -N(CI-6alkyl)2, =0, -CN, -CH3, and -CF3.

72. The compound or salt of any one of claims 53 to 60, wherein Hy is a 3- to 20-membered heterocycle, optionally substituted with one or more substituents independently selected from:=0;C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -0(CH3), -CH3, and 3- to 10-membered heterocycle.

73. The compound or salt of any one of claims 53 to 72, wherein Hy is a 3- to 20-membered heterocycle, optionally substituted with one or more substituents independently selected from: C3-10 carbocycle and 3- to 10-membered heterocycle, optionally substituted with one or more substituents independently selected from: =0.

74. The compound or salt of any one of claims 53 to 73, wherein Hy is an optionally substituted 3- to 17-membered heterocycle.

75. The compound or salt of any one of claims 53 to 74, wherein Hy is an optionally substituted 3- to 15-membered heterocycle.

76. The compound or salt of any one of claims 53 to 75, wherein Hy is an optionally substituted 3- to 12-membered heterocycle.

77. The compound or salt of any one of claims 53 to 76, wherein Hy is a bridged heterocycle.

78. The compound or salt of any one of claims 53 to 77, wherein Hy is a fused heterocycle.

79. The compound or salt of any one of claims 53 to 78, wherein Hy is a bridged and fused heterocycle.

80. The compound or salt of any one of claims 53 to 79, wherein Hy is selected from a heterocycloalkenyl which is optionally substituted.

81. The compound or salt of any one of claims 53 to 80, wherein Hy is selected fromwhich is optionally substituted.

82. The compound or salt of any one of claims 53 to 81, wherein Hy is selected fromis optionally substituted.

83. The compound or salt of any one of claims 53 to 68 wherein Hy is selected from85. A compound represented by Formula (II-A)or a salt thereof, wherein:X11, X12, X13, and X14are independently selected from C(R10), and N; wherein no more than two of X11, X12, X13, and X14are N; wherein no more than three of X11, X12, X13, and X14are C(H); each R10is independently selected from: hydrogen, halogen, -NO2, -CN, -N3, -OR18, -SR18, -N(R18)2, -C(O)R18, - C(O)N(R18)2, -N(R18)C(O)R18, -N(R18)C(O)N(R18)2, -OC(O)N(R18)2, - N(R18)C(O)OR18, -C(O)OR18, -OC(O)R18, -S(O)R18, and -S(O)2R18;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR18, -SR18, - N(R18)2, -C(O)R18, -C(O)N(R18)2, -N(R18)C(O)R18-C(O)OR18, -OC(O)R18, - N(R18)C(O)N(R18)2, -OC(O)N(R18)2, -N(R18)C(O)OR18, -S(O)R18, -S(O)2R18, -NO2, =0, =S, =N(R18), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3- 10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R17; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR18, - SR18, -N(R18)2, -C(0)R18, -C(O)N(R18)2, -N(R18)C(O)R18, -N(R18)C(O)N(R18)2, - OC(O)N(R18)2, -N(R18)C(O)OR18, -C(0)0R18, -0C(0)R18, -S(O)R18, -S(O)2R18, -NO2, =0, =S, =N(R18), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R17;R11is selected from: hydrogen;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R18a, -SR18a, - N(R18a)2, -C(0)R18a, -C(O)N(R18a)2, -N(R18a)C(O)R18a, -C(0)0R18a, -0C(0)R18a, - N(R18a)C(O)N(R18a)2, -OC(O)N(R18a)2, -N(R18a)C(O)OR18a, -S(O)R18a, -S(O)2R18a, -N02, =0, =S, =N(R18a), -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17a; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R18a, - SR18a, -N(R18a)2, -C(0)R18a, -C(O)N(R18a)2, -N(R18a)C(O)R18a, -N(R18a)C(O)N(R18a)2, - OC(O)N(R18a)2, -N(R18a)C(O)OR18a, -C(0)0R18a, -0C(0)R18a, -S(O)R18a, -S(O)2R18a, -N02, =0, =S, =N(R18a), -CN, Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R17a; orR11together with R12form a C3-10 cycloalkyl, C5-10 cycloalkenyl, 3- to 10- membered heterocycloalkyl, or 5- to 10-membered heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R18a, -SR18a, -N(R18a)2, -C(0)R18a, -C(O)N(R18a)2, -N(R18a)C(O)R18a, - N(R18a)C(O)N(R18a)2, -OC(O)N(R18a)2, -N(R18a)C(O)OR18a, -C(0)0R18a, -0C(0)R18a, - S(O)R18a, -S(O)2R18a, -N02, =0 , =S, =N(R18a), -CN, Ci-6alkyl, C2.6alkenyl, and C2.6alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R17a; ted from:C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R18b, - SR18b, -N(R18b)2, -C(0)R18b, -C(O)N(R18b)2, -N(R18b)C(O)R18b-N(R18b)C(O)N(R18b)2, - OC(O)N(R18b)2, -N(R18b)C(O)OR18b, -C(0)0R18b, -0C(0)R18b, -S(O)R18b, -S(O)2R18b, - N02, =0, =S, =N(R18b), -CN, -N3, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17b; orR11together with R12form a C3-10 cycloalkyl, C5-10 cycloalkenyl, 3- to 10- membered heterocycloalkyl, or 5- to 10-membered heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R18a, -SR18a, -N(R18a)2, -C(0)R18a, -C(O)N(R18a)2, -N(R18a)C(O)R18a, - N(R18a)C(O)N(R18a)2, -OC(O)N(R18a)2, -N(R18a)C(O)OR18a, -C(0)0R18a, -0C(0)R18a, - S(O)R18a, -S(O)2R18a, -N02, =0 , =S, =N(R18a), -CN, Ci-6alkyl, C2.6alkenyl, and C2.6alkynyl, wherein Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R17a; orR12together with R13form a 3- to 20-membered heterocycloalkyl or a 5-to 20- membered heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R18a, -SR18a, -N(R18a)2, -C(0)R18a, - C(O)N(R18a)2, -N(R18a)C(O)R18a, -N(R18a)C(O)N(R18a)2, -OC(O)N(R18a)2, - N(R18a)C(O)OR18a, -C(0)0R18a, -0C(0)R18a, -S(O)R18a, -S(O)2R18a, -N02, =0, =S, =N(R18a), -CN, Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R17b;R13is selected from: hydrogen; andC1-6 alkyl optionally substituted with one or more substituents independently selected from R17c; orR12together with R13form a 3- to 20-membered heterocycloalkyl or a 5-to 20- membered heterocycloalkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8a, -SR8a, -N(R8a)2, -C(O)R8a, - C(O)N(R8a)2, -N(R8a)C(O)R8a, -N(R8a)C(O)N(R8a)2, -OC(O)N(R8a)2, - N(R8a)C(O)OR8a, -C(O)OR8a, -OC(O)R8a, -S(O)R8a, -S(O)2R8a, -NO2, =0, =S, =N(R8a), - CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle and 3- to 10- membered heterocycle are each optionally substituted with one or more substituents independently selected from R17b;R14is selected from: hydrogen; andC1-6 alkyl substituted with one or more substituents independently selected from halogen, -0R18d, -SR18d, -N(R18d)2, -NO2, and -CN, C3-10 carbocycle, and 3- to 10- membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17d; orR14and R14atogether form a C3-10 carbocycle, or 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, or 3- to 10-membered heterocycle, is optionally substituted with one or more substituents independently selected from R17d;R14ais selected from: hydrogen, halogen, -0R18e, -SR18e, -N(R18e)2, -NO2, and -CN; andC1-6 alkyl substituted with one or more substituents independently selected from halogen, -0R18d, -SR18d, -N(R18d)2, -NO2, and -CN, C3-10 carbocycle, and 3- to 10- membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17d; orR14and R14atogether form a C3-10 carbocycle, or 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, or 3- to 10-membered heterocycle, is optionally substituted with one or more substituents independently selected from R17d;R15is selected from: halogen, -OR18e, -SR18e, -N(R18e)2, -NO2, and -CN;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from R17e; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from R17e; 16is selected from: hydrogen; andC1-6 alkyl optionally substituted with one or more substituents independently selected from R17f; each R17, R17a, R17b, R17c, R17d, R17e, and R17fis independently selected from: hydrogen, halogen, -CN, -OH, -SH, -NO2, -NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, - N(CI-6 alkyl)2, and -NH(CI-6 alkyl); andC1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10- membered heterocycle, and Ci-e haloalkyl; each R18, R18a, R18b, R18c, R18d, and R18eis independently selected from: hydrogen, halogen, -CN, -OH, -SH, -N02, -NH2, -O-C1-6 alkyl, -S-C1-6 alkyl, - N(CI-6 alkyl)2, and -NH(CI-6 alkyl); andC1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-10 carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -SO2-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10- membered heterocycle, and Ci-e haloalkyl.

86. The compound or salt of claim 85, wherein R10is selected from: hydrogen, halogen;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR18, -N(R18)2;C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR18, - N(R18)2, -C(O)N(R18)2, -N(R18)C(O)R18, -N(R18)C(O)N(R18)2, -S(O)2R18, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R17.

87. The compound or salt of claim 85 or 86, wherein R11is selected from: hydrogen;C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -0R18a, -N(R18a)2, -C(O)N(R18a)2, -S(O)2R18a, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10- membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17a; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R18a, - N(R18a)2, -C(O)N(R18a)2, -S(O)2R18a, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10-membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17a; orR11together with R12form a C3-10 carbocycle, or 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -0R18a, -N(R18a)2, -C(O)N(R18a)2, -S(O)2R18a, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle, and 3- to 10- membered heterocycle, are each optionally substituted with one or more substituents independently selected from R17a.

88. The compound or salt of any one of claims 85 to 87, wherein R12is selected from:C3-6 carbocycle, and 3- to 6-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -NH2, =0, -O-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle, and -C(O)N(R18b)2, wherein each C3-10 carbocycle and 3- to 10- membered heterocycle is optionally substituted with one or more substituents independently selected from R17b.

89. The compound or salt of any one of claims 85 to 88, wherein90. The compound or salt of any one of claims 85 to 89, wherein R12together with R13form an optionally substituted 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR8a, -SR8a, -N(R8a)2, -C(O)R8a, -C(O)N(R8a)2, -S(O)2R8a, =0, Ci-6alkyl, C3-10 carbocycle and 3- to 10- membered heterocycle, wherein C1-6 alkyl, C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R17b.

91. The compound or salt of any one of claims 85 to 90, wherein R12together with R13form a heterocycle selected from:

92. The compound or salt of any one of claims 85 to 91, wherein R15is selected from: halogen, -OR18e, -N(R18e)2, and -CN;Ci-6 alkyl, optionally substituted with one or more substituents independently selected from R17e;C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from R17e93. The compound or salt of any one of claims 85 to 92, wherein R15is selected from: fluoro, -CH3,94. The compound or salt of claim 85, selected from:

95. A pharmaceutical composition comprising a compound or salt of any one of claims 1 to 94 and a pharmaceutically acceptable excipient.

96. A method of treating a metabolic disease, diabetes, a neuromuscular condition, a skeletal muscular condition, sarcopenia, muscle wasting, muscle spasm, inducing weight loss, or of inducing muscle gain, the method comprising administering to a patient in need thereof a compound or salt of any one of claims 1 to 94 or the pharmaceutical composition of claim 95.

97. The method of claim 96, wherein the metabolic disease is selected from obesity, morbid obesity, super morbid obesity, pre-diabetes, diabetes, or a metabolic syndrome.

98. The method of claim 96 or 97, wherein the metabolic disease is selected from obesity, morbid obesity, super morbid obesity, pre-diabetes, or diabetes.

99. The method of claim 98, wherein metabolic disease is obesity.

100. The method of claim 98, wherein diabetes is selected from type 1 diabetes and type 2 diabetes.

101. The method of claim 97, wherein the metabolic syndrome comprises high blood pressure, high blood sugar, excess body fat around the waist, or irregular cholesterol levels.

102. The method of any one of claims 96 to 101, further comprising the administration of a second therapeutic agent.

103. The method of claim 102, wherein the second therapeutic agent comprises a GLP-1 modulator or SGLT2 modulator, GIP modulator, a secretagogue, or alpha-glucosidase modulator.

104. The method of claim 102, wherein the second therapeutic agent comprises Dulaglutide, Exenatide, Semaglutide, Liraglutide, Lixisenatide, or Tirzepatide.

105. A method of extending the amount of time muscle fibers reside in a DRX state or increasing the population of muscle fibers residing in the DRX state, the method comprising administering to a patient in need thereof a compound or salt of any one of claims 1 to 94 or the pharmaceutical composition of claim 95.

106. A method of extending the amount of time muscle fibers reside in a DRX state or increasing the population of muscle fibers residing in the DRX state, the method comprising administering to a patient in need thereof a compound of any one of claims 1 to94 or the pharmaceutical composition of claim 95.

107. The method of claim 105 or 106, wherein the amount of time muscle fibers reside in a DRX state is increased by 5% or more.

108. The method of claim 105 or 106, wherein the population of muscle fibers residing in the DRX state is increased by 5% or more.

109. The method of claim 105 or 106, wherein the resting energy consumption rate of the subject is increased 5% or more.

110. A method of modulating myosin, the method comprising administering a therapeutically effective amount of a compound or salt of any one of claims 1 to 94 or the pharmaceutical composition of claim 95.

111. The method of claim 110, wherein the myosin is skeletal myosin or cardiac myosin.

112. The method of claim 111, wherein the myosin is skeletal myosin, and the modulation is activation or inhibition.

113. The method of claim 112, wherein the myosin is skeletal myosin, and the modulation is activation.

114. The method of claim 112, wherein the myosin is skeletal myosin, and the modulation is inhibition.

115. The method of claim 111, wherein the myosin is cardiac myosin, and the modulation is activation or inhibition.

116. The method of claim 115, wherein the myosin is cardiac myosin, and the modulation is activation.

117. The method of claim 115, wherein the myosin is cardiac myosin, and the modulation is inhibition.

118. The method of claim 113, wherein the modulation is skeletal activation, and the method is for inducing weight loss; inducing muscle gain; extending the amount of time muscle fibersreside in a DRX state; increasing the population of muscle fibers residing in the DRX state; or treating a condition selected from: a metabolic disease, activity-induced muscle damage, a neuromuscular condition, a skeletal muscular condition, sarcopenia, muscle wasting, and muscle spasm.

119. The method of claim 118, wherein the method is for treating obesity.

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