Quinazolinone compounds and uses thereof

Abstract

Provided herein are quinazolinone compounds for modulating muscle myosin to treat obesity and related disorders such as cardiovascular diseases, type 2 diabetes, obstructive sleep apnea, cancer, and osteoarthritis.

Description

QUINAZOLINONE COMPOUNDS AND USES THEREOFCROSS-REFERENCE

[0001] This application claims the benefit of U.S. Provisional Patent Application No. 63 / 570,071, filed March 26, 2024, which is incorporated herein by reference in its entirety. This application claims the benefit of U.S. Provisional Patent Application No. 63 / 702,593, filed October 2, 2024, which is incorporated herein by reference in its entirety.BACKGROUND OF THE INVENTION

[0002] Obesity is a medical condition involving excess body fat accumulated to such an extent that it can potentially have negative effects on health. Obesity is a major cause of disability and is correlated with various diseases and conditions, particularly cardiovascular diseases, type 2 diabetes, obstructive sleep apnea, certain types of cancer, and osteoarthritis. Obesity is a leading preventable cause of death worldwide, with increasing rates in adults and children. In 2022, over 1 billion people were obese worldwide. Excess body fat underlies 64% of cases of diabetes in men and 77% of cases in women.SUMMARY OF THE INVENTIONThe disclosure provides compound and salts thereof for use in treating disease. In certain aspects, the disclosure provides compounds of Formulas (I), (I-A), (I-B), (I-C), (II), (II-A), (II-B), (III), (III-A), (III-C), (IV), (IV-A), (IV-C), and (V), pharmaceutical compositions thereof as well as methods of use in the treatment of disease.INCORPORATION BY REFERENCE

[0003] All publications, patents, and patent applications mentioned in this specification are herein incorporated by reference to the same extent as if each individual publication, patent, or patent application was specifically and individually indicated to be incorporated by reference.DETAILED DESCRIPTION OF THE INVENTION

[0004] In certain aspects, the disclosure provides methods for treating a cardiac disease in an individual in need thereof, the method comprising administering a therapeutically effective amount of a compound of Formula (I), (I-A), (I-B), (I-C), (II), (II-A), (II-B), (III), (III-A), (III-C), (IV), (IV- A), (IV-C), (V), or (V-A). In certain aspects, the disclosure provides methods for treating metabolic disease, diabetes, a neuromuscular condition, a skeletal muscular condition, sarcopenia, muscle wasting, muscle spasm, inducing weight loss, or of inducing muscle gain in an individual in need thereof, the method comprising administering a therapeutically effective amount of a compound ofFormula (I), (I-A). (II), (III), (III-A), (IV), (V), (V-A), (VI), or (VII). In certain aspects, the disclosure provides compounds of Formula (I), (I-A). (II), (in), (III-A), (IV), (V), (V-A), (VI), or (VII).Definitions

[0005] Unless defined otherwise, all technical and scientific terms used herein have the same meaning as is commonly understood by one of skill in the art to which this invention belongs.

[0006] As used in the specification and claims, the singular form “a”, “an” and “the” includes plural references unless the context clearly dictates otherwise.

[0007] The term “Cx-y” or “Cx-Cy” (e.g., when used in conjunction with a chemical moiety, such as alkyl, alkenyl, or alkynyl) is meant to include groups that comprise a number of carbon atoms greater than or equal to x carbon atoms and less than or equal to y carbon atoms in the chemical moiety, subject to the following. The term “Cx.y” or “Cx-Cy” is not meant to limit the number of carbon atoms which may be attached to the chemical moiety when the chemical moiety is substituted with a second chemical moiety. For example, the term “Ci-6 alkyl” or “Ci to G, alkyl” refers to saturated, substituted or unsubstituted, hydrocarbon groups, including straight-chain alkyl groups (e.g., linear alkyl groups) and branched alkyl groups that contain 1, 2, 3, 4, 5, or 6 carbon atoms, plus however many carbon atoms may be present in any substituents of the Ci-6 alkyl. For example, if a Ci-6 alkyl is optionally substituted with a second chemical moiety comprising two carbon atoms, then it will be understood that the Ci-6 alkyl can include between 1 and 8 carbon atoms.

[0008] The terms “Cx-yalkenyl” and “Cx.yalkynyl” refer to substituted or unsubstituted unsaturated aliphatic groups analogous in length and possible substitution to the alkyls described above, but that contain at least one double or triple bond, respectively.

[0009] " Amino" refers to the -NH2 moiety.

[0010] "Cyano" refers to the -CN moiety.

[0011] "Nitro" refers to the -NO2 moiety.

[0012] " Oxa" refers to the -O- moiety.

[0013] " Oxo" refers to the =0 moiety.

[0014] " Thioxo" refers to the =S moiety.

[0015] "Imino" refers to the =N-H moiety.

[0016] "Oximo" refers to the =N-0H moiety.

[0017] "Hydrazino" refers to the =N-NH2 moiety.

[0018] "Alkyl" refers to a straight (e g., linear) or branched (e g., nonlinear) hydrocarbon moiety consisting solely of carbon and hydrogen atoms, fully saturated. In certain embodiments, “alkyl” comprises one to fifteen carbon atoms (e.g., C1-C15 alkyl). In certain embodiments, an alkylcomprises one to thirteen carbon atoms (e.g., C1-C13 alkyl). In certain embodiments, an alkyl comprises one to eight carbon atoms (e.g., Ci-Cs alkyl). In certain embodiments, an alkyl comprises one to six carbon atoms e.g., Ci-Ce alkyl). In other embodiments, an alkyl comprises one to five carbon atoms (e.g., C1-C5 alkyl). In other embodiments, an alkyl comprises one to four carbon atoms (e.g., C1-C4 alkyl). In other embodiments, an alkyl comprises one to three carbon atoms (e.g., C1-C3 alkyl). In other embodiments, an alkyl comprises one to two carbon atoms (e.g., C1-C2 alkyl). In other embodiments, an alkyl comprises one carbon atom (e.g., Ci alkyl, e.g., methyl). In other embodiments, an alkyl comprises five to fifteen carbon atoms (e.g., C5-C15 alkyl). In other embodiments, an alkyl comprises five to eight carbon atoms (e.g., Cs-Cs alkyl) In other embodiments, an alkyl comprises two to five carbon atoms (e.g., C2-C5 alkyl). In other embodiments, an alkyl comprises three to five carbon atoms (e.g., C3-C5 alkyl). In other embodiments, the alkyl group is selected from methyl, ethyl, 1-propyl ( / / -propyl). 1-methylethyl (2-propyl, / .w-propyl). 1- butyl ( / / -butyl), 1 -methylpropyl (sec-butyl), 2-methylpropyl (z'.w-butyl), 1,1 -dimethylethyl (Ze / 'Z-butyl), and 1 -pentyl ( / / -pentyl). The alkyl is attached to the rest of the molecule by a single bond.

[0019] “Aminoalkyl” refers to a moiety bonded through a nitrogen atom of the form -N(H)(alkyl) or N(alkyl)(alkyl), wherein when the moiety is N(alkyl)(alkyl), the two alkyl groups bonded to nitrogen can be the same alkyl groups or different alkyl groups.

[0020] "Alkoxy" refers to a moiety bonded through an oxygen atom of the formula -O-alkyl, where alkyl is an alkyl chain as defined above.

[0021] "Alkenyl" refers to a straight (e.g., linear) or branched (e.g., nonlinear) hydrocarbon moiety consisting solely of carbon and hydrogen atoms, the moiety comprising at least one carbon-carbon double bond. In certain embodiments, an alkenyl comprises two to twelve carbon atoms. In certain embodiments, an alkenyl comprises two to eight carbon atoms. In other embodiments, an alkenyl comprises two to four carbon atoms. The alkenyl is attached to the rest of the molecule by a single bond, for example, ethenyl (e.g., vinyl), prop-l-enyl (e.g., allyl), but-l-enyl, pent-l-enyl, penta- 1,4-dienyl, and the like.

[0022] "Alkynyl" refers to a straight (e.g., linear) or branched (e.g., nonlinear) hydrocarbon moiety consisting solely of carbon and hydrogen atoms, the moiety comprising at least one carbon-carbon triple bond. In some embodiments, an alkynyl comprises from two to twelve carbon atoms. In some embodiments, an alkynyl optionally further comprises at least one carbon-carbon double bond. In certain embodiments, an alkynyl comprises two to eight carbon atoms. In other embodiments, an alkynyl comprises two to six carbon atoms. In other embodiments, an alkynyl comprises two to fourcarbon atoms. The alkynyl is attached to the rest of the molecule by a single bond, for example, ethynyl, propynyl, butynyl, pentynyl, hexynyl, and the like.

[0023] “Alkylene” or “alkylene chain” refers to a linear (e g., straight), or branched (e g., nonlinear), divalent, hydrocarbon moiety. An “alkylene” or “alkylene chain” can link a portion of the molecule to a second moiety. An “alkylene” or “alkylene chain” consists solely of carbon and hydrogen atoms (substitution of an alkylene with one or more substituents comprising atoms other than hydrogen, such as N, O, and S, may be specified). An “alkylene” or “alkylene chain” can contain no unsaturation (notwithstanding the points of attachment of an alkylene to the rest of the molecule). In certain embodiments, the “alkylene” or “alkylene chain” and comprises one to twelve carbon atoms, for example, methylene, ethylene, propylene, n-butylene, and the like. The alkylene chain can be attached to the portion of the molecule through a single bond and to the second moiety through a single bond. The points of attachment of an alkylene chain to the rest of the molecule and to the second moiety can be through one carbon atom in the alkylene chain or can be through any two carbon atoms within the alkylene. In certain embodiments, an alkylene comprises one to eight carbon atoms (e.g., Ci-Cs alkylene). In other embodiments, an alkylene comprises one to five carbon atoms (e.g., C1-C5 alkylene). In other embodiments, an alkylene comprises one to four carbon atoms (e.g., C1-C4 alkylene). In other embodiments, an alkylene comprises one to three carbon atoms (e.g., C1-C3 alkylene). In other embodiments, an alkylene comprises one to two carbon atoms (e.g., C1-C2 alkylene). In other embodiments, an alkylene comprises one carbon atom (e.g., Ci alkylene). In other embodiments, an alkylene comprises five to eight carbon atoms (e.g., Cs-Cs alkylene). In other embodiments, an alkylene comprises two to five carbon atoms (e.g., C2-C5 alkylene). In other embodiments, an alkylene comprises three to five carbon atoms (e.g., C3-C5 alkylene).

[0024] "Alkenylene" or "alkenylene chain" refers to a linear (e.g., straight), or branched, divalent, hydrocarbon moiety. An "alkenylene" or "alkenylene chain" can link a portion of the molecule to a second moiety. An "alkenylene" or "alkenylene chain" consists solely of carbon and hydrogen atoms (substitution of an alkenylene with one or more substituents comprising atoms other than hydrogen, such as N, O, and S, may be specified). An "alkenylene" or "alkenylene chain" comprises at least one carbon-carbon double bond. In certain embodiments, an "alkenylene" or "alkenylene chain" comprises from two to twelve carbon atoms. The alkenylene chain can be attached to the portion of the molecule through a single bond and to the second moiety through a single bond. The points of attachment of an alkenylene chain to the rest of the molecule and to the second moiety can be through one carbon atom in the alkenylene chain or through any two carbon atoms within the alkenylene chain. In certain embodiments, an alkenylene comprises two to eight carbon atoms (e.g, C2-C8 alkenylene). In other embodiments, an alkenylene comprises two to five carbon atoms (e. ,C2-C5 alkenylene). In other embodiments, an alkenylene comprises two to four carbon atoms (e.g.,C2-C4 alkenylene). In other embodiments, an alkenylene comprises two to three carbon atoms (e.g.,C2-C3 alkenylene). In other embodiments, an alkenylene comprises five to eight carbon atoms (e.g.,Cs-Cs alkenylene). In other embodiments, an alkenylene comprises two to five carbon atoms (e.g.,C2-C5 alkenylene). In other embodiments, an alkenylene comprises three to five carbon atoms (e.g., C3-C5 alkenylene).

[0025] "Alkynylene" or "alkynylene chain" refers to a linear (e.g., straight), or branched, divalent, hydrocarbon moiety. An “alkynylene" or "alkynylene chain" can link a portion of the molecule to a second moiety. An “alkynylene" or "alkynylene chain" consists solely of carbon and hydrogen (substitution of an alkynylene with one or more substituents comprising atoms other than hydrogen, such as N, O, and S, may be specified). An “alkynylene" or "alkynylene chain" comprises at least one carbon-carbon triple bond. In certain embodiments, an “alkynylene" or "alkynylene chain" comprises from two to twelve carbon atoms. An alkynylene chain can be attached to the portion of the molecule through a single bond and to the second moiety through a single bond. The points of attachment of an alkynylene chain to the rest of the molecule and to the second moiety can be through one carbon atom in the alkynylene chain or through any two carbon atoms within the alkynylene chain. In certain embodiments, an alkynylene comprises two to eight carbon atoms (e.g., C2-C8 alkynylene). In other embodiments, an alkynylene comprises two to five carbon atoms (e.g., C2-C5 alkynylene). In other embodiments, an alkynylene comprises two to four carbon atoms (e.g., C2-C4 alkynylene). In other embodiments, an alkynylene comprises two to three carbon atoms (e.g., C2-C3 alkynylene). In other embodiments, an alkynylene comprises two carbon atoms (e.g., C2 alkynylene). In other embodiments, an alkynylene comprises five to eight carbon atoms (e.g., Cs-Cs alkynylene). In other embodiments, an alkynylene comprises three to five carbon atoms (e.g., C3-C5 alkynylene).

[0026] The term “carbocycle” as used herein refers to a saturated or unsaturated (e g., aromatic or nonaromatic unsaturated) ring or ring system in which each atom of the ring is carbon. The term “carbocycle” comprises “aryls,” “cycloalkenyls,” and “cycloalkyls.” For example, the term “carbocycle” includes 3- to 12-membered monocyclic rings (e.g., 3- to 10- membered monocyclic rings) and 4- to 20-membered polycyclic ring systems (e.g., 5- to 15-membered spiro polycyclic ring systems, 5- to 15-membered bridged polycyclic ring systems, or 4- to 15-membered fused polycyclic ring systems). For example, carbocycle includes 4- to 15-membered bicyclic rings (e g., 5- to 15- membered spiro bicycles, 5- to 15-membered bridged bicyclic ring systems, or 4- to 15-membered fused bicyclic ring systems). For example, carbocycle includes tricyclic ring systems, which may be bridged, fused, spiro, or a combination thereof. For example, carbocycle includes tetracyclic ringsy stems, which may be bridged, fused, spiro, or a combination thereof. For example, carbocycle includes ring systems that are both fused and bridged; ring systems that are both fused and spiro; ring systems that are both bridged and spiro; and ring systems that are both fused and bridged and are also spiro. Each ring of a polycyclic carbocycle may be selected from saturated and unsaturated (e.g., aromatic or nonaromatic unsaturated) rings. In an exemplary embodiment, an aromatic ring (e.g., phenyl) of a polycyclic carbocycle may be fused to a saturated or unsaturated ring (e g., cyclohexane, cyclopentane, cyclohexene, or phenyl). A polycyclic carbocycle includes any combination of saturated and unsaturated (e.g., aromatic or nonaromatic unsaturated)rings, as valence permits. For example, polycyclic carbocycles can be spiro bicyclic rings, such as spiropentane. For example, a polycyclic carbocycle includes any combination of ring sizes such as 2-2 spiro ring systems (e.g., spiro[2.2]pentane), 3-3 spiro ring systems, 4-4 spiro ring systems, 4-5 fused ring systems (e.g., bicyclo[4.5.0] fused ring systems), 5-5 fused ring systems, 5-6 fused ring systems, 6-6 fused ring systems (e.g., naphthalene), 5-7 fused ring systems, 6-7 fused ring systems, 5-8 fused ring systems, and 6-8 fused ring systems. Exemplary carbocycles include cyclopentyl, cyclohexyl, cyclohexenyl, adamantyl, phenyl, indanyl, naphthyl, Zra / / .v-bicyclo[44.0]decane, cz -bicylo[4.4.0]decane, spiro[3.4]octane, fluoranthene, and bicyclo[l. l.l]pentanyl. In some embodiments, a carbocycle may be bridged, fused, spiro, or any combination thereof. In some embodiments, a carbocycle is a bridged carbocycle. In some embodiments, a carbocycle is a fused carbocycle. In some embodiments, a carbocycle is a spiro carbocycle. In some embodiments, a carbocycle is a bridged and fused carbocycle. In some embodiments, a carbocycle is a bridged and spiro carbocycle. In some embodiments, a carbocycle is a fused and spiro carbocycle. In some embodiments, a carbocycle is a bridged, fused and spiro carbocycle.

[0027] The term “aryl” refers to an aromatic monocyclic or aromatic polycyclic hydrocarbon ring system comprising at least one cyclic, delocalized (4n+2) ^-electronic system, wherein n is an integer greater than or equal to 0, in accordance with Hiickel theory. In some embodiments, the aromatic monocyclic or aromatic polycyclic hydrocarbon ring system comprises only hydrogen atoms and carbon atoms. In some embodiments, the aromatic monocyclic or polycyclic system contains from three to twenty carbon atoms. In some embodiments, at least one of the rings in the polycyclic aromatic ring system is aromatic. In some embodiments, the aromatic monocyclic or aromatic polycyclic hydrocarbon ring system comprises a cyclic, delocalized (4n+2) 7i-electronic system in accordance with Hiickel theory. In some embodiments, the ring system from which aryl groups are derived include, but are not limited to, groups such as benzene, fluorene, indane, indene, anthracene, tetralin, and naphthalene. In some embodiments, the aryl substituent is not charged (e.g., neutral). In some embodiments, the aryl substituent bears no charges. In some embodiments, the arylsubstituent bears no net charge. In some embodiments, the aryl substituent bears no net charge and is not zwitterionic. In some embodiments, none of the carbon atoms of the aryl substituent are charged. In some embodiments, none of the carbon atoms of the aryl substituent are charged.

[0028] The term "cycloalkyl" refers to a saturated ring in which each atom of the ring is carbon. Cycloalkyl may include monocyclic and polycyclic rings such as 3- to 10-membered monocyclic rings, 5- to 12-membered bicyclic rings, 5- to 12-membered spiro bicycles, and 5- to 12-membered bridged rings. In certain embodiments, a cycloalkyl comprises three to ten carbon atoms. In other embodiments, a cycloalkyl comprises three to seven carbon atoms. In other embodiments, a cycloalkyl comprises five to seven carbon atoms. The cycloalkyl may be attached to the rest of the molecule by a single bond. Examples of monocyclic cycloalkyls include, e.g., cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, and cyclooctyl. Examples of polycyclic cycloalkyls include, but are not limited to, adamantyl, spiropentane, norbomyl (e.g., bicyclo[2.2. l]heptanyl), decalinyl, 7,7 dimethyl bicyclo[2.2.1]heptanyl, bicyclo[I.l. l]pentanyl, spiropentane, and the like.

[0029] The term "cycloalkenyl" refers to a saturated ring in which each atom of the ring is carbon and there is at least one double bond between two ring carbon atoms. Cycloalkenyl may include monocyclic and polycyclic rings, such as 3- to 10-membered monocyclic rings and 4- to 12- membered bicyclic rings (e.g., 5- to 12-membered bridged bicyclic rings, fused 4- to 12-membered bicyclic rings, and spiro 5- to 12-membered bicyclic rings). In other embodiments, a cycloalkenyl comprises five to seven carbon atoms. The cycloalkenyl may be attached to the rest of the molecule by a single bond. Examples of monocyclic cycloalkenyls include, e.g., cyclopentenyl, cyclohexenyl, cycloheptenyl, and cyclooctenyl.

[0030] The term “halo” or, alternatively, “halogen” or “halide,” means fluoro, chloro, bromo or iodo. In some embodiments, a halo is fluoro, chloro, or bromo. In some embodiments, a halo is a fluoro or a chloro. In some embodiments, a halo is a fluoro. In some embodiments, a halo is a chloro.

[0031] The term “haloalkyl” refers to an alkyl, as defined above, that is substituted by one or more halogens, for example, trifluoromethyl, dichloromethyl, bromomethyl, 2,2,2-trifluoroethyl, l-chloromethyl-2-fluoroethyl, and the like. In some embodiments, the alkyl part of the haloalkyl is optionally further substituted as described herein.

[0032] The term “heterocycle” as used herein refers to a saturated or unsaturated (e.g., aromatic or nonaromatic unsaturated) ring or ring system in which one or more heteroatom(s) is(are) member(s) of the ring or ring system. Exemplary heteroatoms include N, O, Si, P, B, and S atoms. For example, heterocycles include 3- to 12-membered monocyclic rings (e.g., 3- to 10- membered monocyclic rings) and 4- to 20-membered polycyclic ring systems (e.g., 4- to 15-membered fused poly ring systems, 5- to 15-membered spiro polycyclic ring systems, and 5- to 15-membered bridgedpolycyclic ring systems). In some embodiments, a heterocycle may be bridged, fused, spiro, or any combination thereof. In some embodiments, a heterocycle is a bridged heterocycle. In some embodiments, a heterocycle is a fused heterocycle. In some embodiments, a heterocycle is a spiro heterocycle. In some embodiments, a heterocycle is a bridged and fused heterocycle. In some embodiments, a heterocycle is a bridged and spiro heterocycle. In some embodiments, a heterocycle is a fused and spiro heterocycle. In some embodiments, a heterocycle is a bridged, fused and spiro heterocycle. For example, heterocycles include 4- to 20-membered bicyclic ring systems (e.g., 4- to 15-membered fused bicyclic ring systems, 5- to 15-membered spiro bicyclic ring systems, and 5- to 15-membered bridged bicyclic ring systems). For example, heterocycle includes tricyclic ring systems, which may be bridged, fused, spiro, or a combination thereof. For example, heterocycle includes tetracyclic ring systems, which may be bridged, fused, spiro, or a combination thereof. For example, heterocycle includes ring systems that are both fused and bridged; ring systems that are both fused and spiro; ring systems that are both bridged and spiro; and ring systems that are both fused and bridged and are also spiro. Each ring of a polycyclic heterocycle may be selected from saturated and unsaturated (e.g., aromatic or nonaromatic unsaturated) rings. A polycyclic heterocycle includes any combination of saturated, and unsaturated (e.g., aromatic or nonaromatic unsaturated) rings, as valence permits. In an exemplary embodiment, an aromatic ring, e.g., pyridyl or phenyl, may be fused to a saturated or unsaturated ring, e.g., cyclohexane, cyclopentane, morpholine, piperidine or cyclohexene, in a heterocycle, as long as at least one atom in the resulting fused ring system is a heteroatom. A polycyclic heterocycle includes any combination of ring sizes such as 3-3 spiro, 4-5 fused ring systems, 5-5 fused ring systems, 5-6 fused ring systems, 6-6 fused ring systems, 5-7 fused ring systems, 6-7 fused ring systems, 5-8 fused ring systems, and 6-8 fused ring systems. A bicyclic heterocycle further includes spiro bicyclic rings, e.g., 5 to 12-membered spiro bicycles, such as 2-oxa-6-azaspiro[3.3]heptane. In some embodiments, a heterocycle comprises multiple heteroatoms. In some embodiments, a heterocycle comprises an atom selected from nitrogen, oxygen, and sulfur. In some embodiments, a heterocycle comprises multiple atoms selected from nitrogen, oxygen, and sulfur. In some embodiments, a heterocycle comprises one or more atom(s) selected from nitrogen, oxygen, and sulfur. In some embodiments, a heterocycle comprises one or more atom(s) selected from nitrogen and oxygen. In some embodiments, a heterocycle comprises one or more atom(s) selected from nitrogen and sulfur. In some embodiments, a heterocycle comprises one or more atom(s) selected from oxygen and sulfur. In some embodiments, a heterocycle comprises one or more atom(s) selected from nitrogen. In some embodiments, a heterocycle comprises one or more atom(s) selected from oxygen. In some embodiments, a heterocycle comprises one or more atom(s) selected from sulfur. In some embodiments, aheterocycle does not comprise Boron in the ring. In some embodiments, a heterocycle does not comprise Phosphorus in the ring. In some embodiments, a heterocycle does not comprise Sulfur in the ring. In some embodiments, a heterocycle does not comprise Oxygen in the ring. In some embodiments, a heterocycle does not comprise Nitrogen in the ring. In some embodiments, a heterocycle comprises only heteroatoms selected from nitrogen, oxygen, and sulfur in the ring, and the heterocycle comprises no other heteroatoms in the ring. Nonlimiting examples of heterocycles include pyridine, pyrrole, indole, carbazole, piperidine, oxazole, morpholine, thiophene, benzothiophene, furan, tetrahydrofuran, and pyran. Nonlimiting examples of heterocycles include azepinyl, acridinyl, benzimidazolyl, benzindolyl, 1,3-benzodioxolyl, benzofuranyl, benzoxazolyl, benzo[d]thiazolyl, benzothiadiazolyl, benzo[ / >][l,4]dioxepinyl, benzo[b][l,4]oxazinyl, 1,4-benzodioxanyl, benzonaphthofuranyl, benzoxazolyl, benzodi oxolyl, benzodioxinyl, benzopyranyl, benzopyranonyl, benzofuranyl, benzofuranonyl, benzothienyl (benzothiophenyl), benzothieno[3,2-d]pyrimidinyl, benzotriazolyl, benzo[4,6]imidazo[l,2-a]pyridinyl, carbazolyl, cinnolinyl, cyclopenta[d]pyrimidinyl, 6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidinyl,5.6-dihydrobenzo[h]quinazolinyl, 5,6-dihydrobenzo[h]cinnolinyl, 6,7-dihydro-5H- benzo[6,7]cyclohepta[l,2-c]pyridazinyl, dibenzofuranyl, dibenzothiophenyl, furanyl, furanonyl, furo[3,2-c]pyridinyl, 5,6,7,8,9,10-hexahydrocycloocta[d]pyrimidinyl, 5,6,7,8,9,10-hexahydrocycloocta[d]pyridazinyl, 5,6,7,8,9,10-hexahydrocycloocta[d]pyridinyl, isothiazolyl, imidazolyl, indazolyl, indolyl, indazolyl, isoindolyl, indolinyl, isoindolinyl, isoquinolyl, indolizinyl, isoxazolyl, 5,8-methano-5,6,7,8-tetrahydroquinazolinyl, naphthyridinyl,1.6-naphthyri dinonyl, oxadiazolyl, 2-oxoazepinyl, oxazolyl, oxiranyl, 5,6,6a,7,8,9,10,10a-octahydrobenzo[h]quinazolinyl, 1 -phenyl- 1 / 7-pyrrolyl, phenazinyl, phenothiazinyl, phenoxazinyl, phthalazinyl, pteridinyl, purinyl, pyrrolyl, pyrazolyl, pyrazolo[3,4-d]pyrimidinyl, pyridinyl, pyrido[3,2-d]pyrimidinyl, pyrido[3,4-d]pyrimidinyl, pyrazinyl, pyrimidinyl, pyridazinyl, pyrrolyl, quinazolinyl, quinoxalinyl, quinolinyl, isoquinolinyl, tetrahydroquinolinyl, 5,6,7,8-tetrahydroquinazolinyl,5.6.7.8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidinyl,6.7.8.9-tetrahydro-5H-cyclohepta[4,5]thieno[2,3-d]pyrimidinyl, 5,6,7,8-tetrahydropyrido[4,5-c]pyridazinyl, thiazolyl, thiadiazolyl, triazolyl, tetrazolyl, triazinyl, thieno[2,3-d]pyrimidinyl, thieno[3,2-d]pyrimidinyl, thieno[2,3-c]pyridinyl, and thiophenyl (e.g., thienyl).

[0033] In some embodiments, a heterocycle is attached to the molecule by a carbon atom. In some embodiments, the heterocycle is attached to the molecule by a nitrogen atom.

[0034] In some embodiments, a heterocycle comprises a moiety selected from a heteroaryl, a heterocycloalkyl, and a heterocycloalkenyl. In some embodiments, the heterocycle is a heteroaryl. In some embodiments, the heterocycle is a heterocycloalkyl. In some embodiments, the heterocycle is a heterocycloalkenyl.

[0035] In some embodiments, a heterocycle comprises an atom selected from nitrogen and oxygen. In some embodiments, a heterocycle comprises an atom selected from nitrogen and sulfur In some embodiments, a heterocycle comprises an atom selected from oxygen and sulfur. In some embodiments, a heterocycle comprises an atom selected from nitrogen. In some embodiments, a heterocycle comprises an atom selected from oxygen In some embodiments, a heterocycle comprises an atom selected from sulfur.

[0036] In some embodiments, a heterocycle comprises 1 to 8 heteroatoms. In some embodiments, the heterocycle comprises 1 to 5 heteroatoms. In some embodiments, the heterocycle comprises 1 to 3 heteroatoms. In some embodiments, the heterocycle comprises 1 to 2 heteroatoms. In some embodiments, the heterocycle comprises 1 heteroatom. In some embodiments, the heterocycle comprises 2 heteroatoms. In some embodiments, the heterocycle comprises 3 heteroatoms. In some embodiments, the heterocycle comprises 4 heteroatoms. In some embodiments, the heterocycle comprises 5 heteroatoms. In some embodiments, the heterocycle comprises 6 heteroatoms.

[0037] In some embodiments, a heterocycle comprises a 3-memberd ring, 4-membered ring, 5- membered ring, 6-membered ring, 7-membered ring, 8-membered ring, 9-membered ring, 10- membered ring, 11 -membered ring, 12-membered ring, 13 -membered ring, 14-membered ring, or 15-20 membered ring. In some embodiments, a heterocycle is 3- to 10-membered. In some embodiments, a heterocycle is 3- to 6-membered. In some embodiments, a heterocycle is 5- to 6- membered. In some embodiments, a heterocycle is 9- to 10-membered. In some embodiments, a heterocycle is 9- to 11 -membered. In some embodiments, a heterocycle is 9- to 15-membered.

[0038] In some embodiments, the heterocycle is monosubstituted, di substituted, trisubstituted, tetrasubstituted, or pentasubstituted (e.g., with further substituents in addition to the point of attachment). In some embodiments, the total number of substituents (e.g., atoms other than hydrogen) on the heterocycle (e.g., bonded to the ring of the heterocycle) is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more.

[0039] In some embodiments, in the molecule or moiety (e.g., in a heterocycle), one or more nitrogen atoms, if present, can be optionally quaternized. In some embodiments, the heterocycle substituent is positively charged, some embodiments, the heterocycle moiety is neutral. In some embodiments, the heterocycle substituent is zwitterionic. Alternatively, or in addition, in some embodiments, the heterocycle substituent is not charged. In some embodiments, the heterocyclesubstituent bears no charges. In some embodiments, the heterocycle substituent bears no net charge. In some embodiments, no atoms within the heterocycle substituent bear any net charge. In some embodiments, the heterocycle substituent bears no net charge and is not zwitterionic. The term "heteroaryl" refers to a moiety derived from an aromatic monocyclic or aromatic polycyclic ring system, in which one or more heteroatom(s) is(are) member(s) of the ring system, and the ring system comprises at least one cyclic, delocalized (4n+2) -electronic system, wherein n is an integer greater than or equal to 0, in accordance with Huckel theory. In some embodiments, one or more heteroatom(s) is(are) member(s) of the ring system comprising the cyclic, delocalized (4n+2) 71- electronic system (e.g., the ring with aromaticity). Exemplary heteroatoms include N, O, Si, P, B, and S atoms. In some embodiments, a heteroaryl comprises an aromatic ring, in which one or more heteroatom(s) is(are) member(s) of the ring system, to which one or more nonaromatic rings, each of which may or may not comprise one or more heteroatom(s), may be fused. In some embodiments, a heteroaryl includes one or more heteroatoms selected from nitrogen, oxygen, and sulfur. In some embodiments, a heteroaryl includes multiple heteroatoms selected from nitrogen, oxygen, and sulfur. In certain embodiments, “heteroaryl” includes rings and ring systems comprising 3 to 20 atoms. In some embodiments, “heteroaryl” includes rings and ring systems that comprise two to seventeen carbon atoms and from one to six heteroatoms selected from nitrogen, oxygen and sulfur. As used herein, the heteroaryl moiety is a monocyclic or polycyclic (e.g., bicyclic, tricyclic or tetracyclic) ring system, wherein at least one of the rings in the ring system is aromatic, e.g., it contains a cyclic, delocalized (4n+2) 71-electron system in accordance with the Huckel theory. Heteroaryl includes fused, bridged, and spiro ring systems. The heteroatom(s) in the heteroaryl moiety is(are) optionally oxidized. One or more nitrogen atom(s), if present, is(are) optionally quaternized. The heteroaryl is attached to the rest of the molecule through any atom of the ring(s). Examples of heteroaryls include, but are not limited to, acridinyl, benzimidazolyl, benzindolyl, 1,3-benzodioxolyl, benzofuranyl, benzoxazolyl, benzo[d]thiazolyl, benzothiadiazolyl, benzo[Z>][l,4]dioxepinyl, benzo[b][l,4]oxazinyl, 1,4-benzodioxanyl, benzonaphthofuranyl, benzoxazolyl, benzodi oxolyl, benzodioxinyl, benzopyranyl, benzopyranonyl, benzofuranyl, benzofuranonyl, benzothienyl (benzothiophenyl), benzothieno[3,2-d]pyrimidinyl, benzotriazolyl, benzo[4,6]imidazo[l,2-a]pyridinyl, carbazolyl, cinnolinyl, cyclopenta[d]pyrimidinyl, 6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidinyl, 5,6-dihydrobenzo[h]quinazolinyl, 5,6-dihydrobenzo[h]cinnolinyl, 6,7-dihydro-5H- benzo[6,7]cyclohepta[l,2-c]pyridazinyl, dibenzofuranyl, dibenzothiophenyl, furanyl, furo[3,2-c]pyridinyl, 5,6,7,8,9,10-hexahydrocycloocta[d]pyrimidinyl, 5,6,7,8,9,10-hexahydrocycloocta[d]pyridazinyl, 5,6,7,8,9,10-hexahydrocycloocta[d]pyridinyl, isothiazolyl, imidazolyl, indazolyl, indolyl, isoindolyl, indolinyl, isoindolinyl, isoquinolyl,indolizinyl, isoxazolyl, 5,8-methano-5,6,7,8-tetrahydroquinazolinyl, naphthyridinyl, 1,6-naphthyri dinonyl, oxadiazolyl, oxazolyl, 5,6,6a,7,8,9,10,10a-octahydrobenzo[h]quinazolinyl, 1 -phenyl- 1 H-pyrrolyl, phenazinyl, phenothiazinyl, phenoxazinyl, phthalazinyl, pteridinyl, purinyl, pyrrolyl, pyrazolyl, pyrazolo[3,4-d]pyrimidinyl, pyridinyl, pyrido[3,2-d]pyrimidinyl, pyrido[3,4-d]pyrimidinyl, pyrazinyl, pyrimidinyl, pyridazinyl, pyrrolyl, quinazolinyl, quinoxalinyl, quinolinyl, isoquinolinyl, tetrahydroquinolinyl, 5,6,7,8-tetrahydroquinazolinyl,5.6.7.8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidinyl,6.7.8.9-tetrahydro-5H-cyclohepta[4,5]thieno[2,3-d]pyrimidinyl, 5,6,7,8-tetrahydropyrido[4,5-c]pyridazinyl, thiazolyl, thiadiazolyl, triazolyl, tetrazolyl, triazinyl, thieno[2,3-d]pyrimidinyl, thieno[3,2-d]pyrimidinyl, thieno[2,3-c]pyridinyl, and thiophenyl (e.g., thienyl). In some embodiments, further examples of “heteroaryl” include 5, 6,7,8- tetrahydroquinoline; l,2,3,4-tetrahydro-l,8-naphthyridine; 6,7-dihydro-5H-cyclopenta[b]pyridine; 2,3-dihydro-lH-pyrrolo[2,3-b]pyridine; 4,5,6,7-tetrahydrobenzofuran; 4,5,6,7-tetrahydrofuro[2,3- b]pyridine; 5,6-dihydro-4H-cyclopenta[b]furan; 4,5-dihydrothieno[2,3-b]furan. In some embodiments, the heteroaryl substituent is positively or negatively charged. In some embodiments, the heteroaryl substituent is neutral. In some embodiments, the heteroaryl substituent is zwitterionic; alternatively, or in addition, in some embodiments, the heteroaryl substituent is not charged. In some embodiments, the heteroaryl substituent bears no charges. In some embodiments, the heteroaryl substituent bears no net charge. In some embodiments, the heteroaryl substituent bears no net charge and is not zwitterionic.

[0040] The term “heterocycle” comprises “heteroaryls,” “heterocycloalkenyls,” and “heterocycloalkyls.”

[0041] The term "heterocycloalkyl" refers to a moiety comprising a saturated ring (e.g., a ring with only single bonds connecting the members of the ring), wherein the saturated ring comprises carbon atom(s) and one or more heteroatom(s) as member(s) of the saturated ring, and wherein the saturated ring may be optionally fused, bridged with, or spiro to an additional ring, wherein the additional ring may comprise only carbon atoms as members of the additional ring or wherein the additional ring may comprise one or more heteroatom(s) as member(s) of the additional ring. In some embodiments, a heterocycloalkyl may be covalently bound to one or more carbocycle(s) or heterocycle(s). Exemplary heteroatoms include N, O, Si, P, B, and S atoms. Heterocycloalkyl may include monocyclic and polycyclic rings such as 3- to 10-membered monocyclic rings, 6- to 12-membered bicyclic rings, 5- to 12-membered spiro bicycles, or 5- to 12-membered bridged rings. The heteroatoms in the heterocycloalkyl radical are optionally oxidized. One or more nitrogen atoms, if present, are optionally quatemized. The heterocycloalkyl is attached to the rest of the moleculethrough any atom of the heterocycloalkyl, valence permitting, such as any carbon or nitrogen atoms of the heterocycloalkyl. Examples of heterocycloalkyl radicals include, but are not limited to, dioxolanyl, thienyl[l,3]dithianyl, decahydroisoquinolyl, imidazolinyl, imidazolidinyl, isothiazolidinyl, isoxazolidinyl, morpholinyl, octahydroindolyl, octahydroisoindolyl, 2-oxopiperazinyl, 2-oxopiperidinyl, 2-oxopyrrolidinyl, oxazolidinyl, piperidinyl, piperazinyl, 4-piperidonyl, pyrrolidinyl, pyrazolidinyl, quinuclidinyl, thiazolidinyl, tetrahydrofuryl, trithianyl, tetrahydropyranyl, thiomorpholinyl, thiamorpholinyl, 1-oxo-thiomorpholinyl, 2-oxa-6- azaspiro[3.3]heptane, and 1,1-dioxo-thiomorpholinyl. In some embodiments, a heterocycloalkyl comprises one heteroatom. In some embodiments, a heterocycloalkyl comprises one heteroatom selected from N, O, and S. In some embodiments, a heterocycloalkyl comprises multiple heteroatoms. In some embodiments, a heterocycloalkyl comprises multiple heteroatoms selected from N, O, and S.

[0042] The term "heterocycloalkenyl" refers to a moiety comprising an unsaturated ring (e.g., a ring with either single bonds or double bonds connecting the members of the ring): wherein the unsaturated ring comprises carbon atoms and one or more heteroatom(s); wherein the unsaturated ring may be optionally fused, bridged with, or spiro to an additional ring, wherein the additional ring may comprise only carbon atoms as members of the additional ring or wherein the additional ring may comprise one or more heteroatom(s) as member(s) of the additional ring; and wherein there is at least one double bond between two ringcarbon atoms (e.g., carbon atoms that are members of the unsaturated ring). Heterocycloalkenyl does not include heteroaryl rings. Exemplary heteroatoms include N, O, Si, P, B, and S atoms. Heterocycloalkenyl may include monocyclic and polycyclic rings such as 3- to 10-membered monocyclic rings, 6- to 12-membered bicyclic rings, and 5- to 12- membered bridged rings. In other embodiments, a heterocycloalkenyl comprises five to seven ring atoms. The heterocycloalkenyl may be attached to the rest of the molecule by a single bond.Examples of monocyclic cycloalkenyls include, e.g., pyrroline (dihydropyrrole), pyrazoline (dihydropyrazole), imidazoline (dihydroimidazole), triazoline (dihydrotriazole), dihydrofuran, dihydrothiophene, oxazoline (dihydrooxazole), isoxazoline (dihydroisoxazole), thiazoline (dihydrothiazole), isothiazoline (dihydroisothiazole), oxadiazoline (dihydrooxadiazole), thiadiazoline (dihydrothiadiazole), dihydropyridine, tetrahydropyridine, dihydropyridazine, tetrahydropyridazine, dihydropyrimidine, tetrahydropyrimidine, dihydropyrazine, tetrahydropyrazine, pyran, dihydropyran, thiopyran, dihydrothiopyran, dioxine, dihydrodioxine, oxazine, dihydrooxazine, thiazine, and dihydrothiazine.

[0043] A “spirocyclic” moiety (e.g., a “spiro” moiety) (e g., a spirocyclic heterocycle, a spirocyclic heterocycloalkenyl, a spirocyclic carbocycle, a spirocyclic heterocycloalkyl, a spirocycliccycloalkenyl, or a spirocyclic cycloalkyl) is a polycyclic system (e.g., bicyclic, tricyclic, tetracyclic) system wherein two rings share exactly one atom. Examples of spirocyclic moieties include, but are

[0044] A spirocyclic heterocycle comprises a spirocyclic moiety that comprises at least one heteroatom in the ring system of the spirocyclic moiety. Examples of spirocyclic heterocycles

[0045] A spirocyclic carbocycle comprises a spirocyclic moiety that comprises only carbon atoms in the ring system of the spirocyclic moiety. Examples of spirocyclic carbocycles include, but are not

[0046] A “fused” moiety (e.g., a fused heterocycle, a fused carbocycle, a fused heterocycloalkyl, or a fused cycloalkyl) is a polycyclic system (e.g., bicyclic, tricyclic, tetracyclic) wherein two rings share exactly two atoms. Examples of fused moieties include, but are not limited to:

[0047] A “fused” heterocycle comprises a fused moiety that comprises at least one heteroatom in the ring system of the fused moiety. Examples of fused heterocycles include, but are not limited to:

[0048] A “fused” carbocycle comprises a fused moiety that comprises only carbon atoms in the ring system of the fused moiety. Examples of fused carbocycles include, but are not limited to:

[0049] A “bridged” moiety (e.g., a bridged heterocycle, a bridged carbocycle, a bridged heterocycloalkyl, a bridged heterocycloalkenyl, or a bridged cycloalkyl) is a polycyclic system (e g., bicyclic, tricyclic, tetracyclic) which comprises two or more bridgeheads, wherein in at least one combination of two bridgeheads, each bridgehead in the combination of two bridgeheads is separated from the other bridgehead in the combination of two bridgeheads by three bridges, each bridge comprising at least one atom, wherein each of the three bridges does not contain any of the same atoms as either of the other two bridges.

[0050] In some embodiments, a “bridged” moiety (e.g., a bridged heterocycle, a bridged carbocycle, a bridged heterocycloalkyl, a bridged heterocycloalkenyl, or a bridged cycloalkyl) is a polycyclic system (e.g., bicyclic, tricyclic, tetracyclic) which comprises two or more bridgeheads, wherein in at least one pair of bridgeheads, each bridgehead in the pair is separated from the other bridgehead in the pair by three bridges, each bridge comprising at least one atom, wherein each of the three bridges does not contain any of the same atoms as either of the other two bridges.

[0051] In some embodiments, a bridgehead atom is a sp -hybridized carbon or nitrogen atom that forms a nexus between two or more rings. In some embodiments, a bridge comprises one or more atom(s) connecting two bridgehead atoms.

[0052] Examples of bridged moi eties include, but are not limited to:(bicyclofl .1.1 ]pentane),(bicyclo[2.1.1]hexane), norbornane (2-oxa-5-azabicyclo[2.2.1]heptanebicyclo[3.1.1 ]heptane, bicyclo[2.2.2]octane, twistanespiro[bicyclo[2.2.1]heptane-7, l'-cyclopropane],

[0053] A “bridged” carbocycle comprises a bridged moiety that comprises only carbon atoms in the ring system of the bridged moiety. Examples of bridged carbocycles include, but are not limited to:(bicyclof 1.1.1 ]pentane),(bicyclo[2.1.1]hexane), norbomane (y . . p bicyclo[2.2.2]octane, twistaneisotwistanespiro[bicyclo[2.2.1]heptane-7, l'-cyclopropane], andspiro[bicyclo[2.2.1 ]heptane-2, l'-cyclopropane] .

[0054] A “bridged” heterocycle comprises a bridged moiety that comprises at least one heteroatom in the ring system of the bridged moiety. Examples of bridged heterocycles include, but are not

[0055] The term “substituted” refers to moieties having substituents replacing a hydrogen on one or more carbon atom(s) or substitutable heteroatoms, e g., an NH or NEE of a compound. It will be understood that “substitution” or “substituted with” includes the implicit proviso that such substitution is in accordance with permitted valence of the substituted atom and the substituent and further includes the proviso that the substitution results in a stable compound, e.g., a compound which does not rapidly undergo rearrangement, cyclization, elimination, etc. In certain embodiments, substituted refers to moieties having substituents replacing two hydrogen atoms on the same carbon atom, such as substituting the two hydrogen atoms on a single carbon atom with an oxo, imino, oxime, hydrazone, or thioxo group. As used herein, the term “substituted” is contemplated to include all permissible substituents of organic compounds. In a broad aspect, the permissible substituents include acyclic and cyclic, branched and unbranched, carbocyclic and heterocyclic, aromatic and non-aromatic substituents of organic compounds. The permissible substituents can be one or more and the same or different for appropriate organic compounds.

[0056] In some embodiments, the term “one or more substituents” may refer to one substituent, or two substituents, or three substituents, or four substituents, or five substituents, or six substituents, or more than six substituents. In some embodiments, the term “one or more substituents” may refer to one substituent. In some embodiments, the term “one or more substituents” may refer to two substituents. In some embodiments, the term “one or more substituents” may refer to three substituents. In some embodiments, the term “one or more substituents” may refer to four substituents. In some embodiments, the term “one or more substituents” may refer to five substituents. In some embodiments, the term “one or more substituents” may refer to more than five substituents. In some embodiments, the term “one or more substituents” may refer to 1 substituent to10 substituents. In some embodiments, the term “one or more substituents” may refer to at least 1 substituent. In some embodiments, the term “one or more substituents” may refer to at most 10 substituents. In some embodiments, the term “one or more substituents” may refer to at most 5 substituents. In some embodiments, the term “one or more substituents” may refer to at most 2 substituents. In some embodiments, the term “one or more substituents” may refer to 1 substituent to2 substituents. In some embodiments, the term “one or more substituents” may refer to 1 substituent to 1 substituent. 1 substituent to 3 substituents, 1 substituent to 4 substituents, 1 substituent to 5substituents, 1 substituent to 6 substituents, 1 substituent to 7 substituents, 1 substituent to 10 substituents, 2 substituents to 3 substituents, 2 substituents to 4 substituents, 2 substituents to 5 substituents, 2 substituents to 6 substituents, 2 substituents to 7 substituents, 2 substituents to 10 substituents, 3 substituents to 4 substituents, 3 substituents to 5 substituents, 3 substituents to 6 substituents, 3 substituents to 7 substituents, 3 substituents to 10 substituents, 4 substituents to 5 substituents, 4 substituents to 6 substituents, 4 substituents to 7 substituents, 4 substituents to 10 substituents, 5 substituents to 6 substituents, 5 substituents to 7 substituents, 5 substituents to 10 substituents, 6 substituents to 7 substituents, 6 substituents to 10 substituents, or 7 substituents to 10 substituents. In some embodiments, the term “one or more substituents” may refer to 1 substituent, 2 substituents, 3 substituents, 4 substituents, 5 substituents, 6 substituents, 7 substituents, or 10 substituents.

[0057] In some embodiments, substituents may include any substituents described herein, for example: halogen, hydroxy, oxo (=0), thioxo (=S), cyano (-CN), nitro (-NO2), imino (=N-H), oximo (-N-OH), hydrazino (=N-NH2), -Rb-0Ra, -Rb-OC(O)-Ra, -Rb-OC(O)-ORa, -Rb-0C(0)-N(Ra)2, - Rb-N(Ra)2, -Rb-C(O)Ra, -Rb-C(O)ORa, -Rb-C(0)N(Ra)2, -Rb-0-Rc-C(0)N(Ra)2, -Rb-N(Ra)C(O)ORa, - Rb-N(Ra)C(O)Ra, -Rb-N(Ra)S(O)tRa(where t is 1 or 2), -Rb-S(O)tRa(where t is 1 or 2), -Rb-S(O)tORa(where t is 1 or 2), and -Rb-S(O)tN(Ra)2(where t is 1 or 2); and alkyl, alkenyl, alkynyl, aryl, aralkyl, aralkenyl, aralkynyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, and heteroarylalkyl, any of which may be optionally substituted by alkyl, alkenyl, alkynyl, halogen, haloalkyl, haloalkenyl, haloalkynyl, oxo (=0), thioxo (=S), cyano (-CN), nitro (-NO2), imino (=N- H), oximo (=N-0H), hydrazine (=N-NH2), -Rb-0Ra, -Rb-OC(O)-Ra, -Rb-0C(0)-0Ra, - Rb-OC(O)-N(Ra)2, -Rb-N(Ra)2, -Rb-C(0)Ra, -Rh-C(O)ORa, -Rb-C(0)N(Ra)2, -Rb-0-Rc-C(0)N(Ra)2, - Rb-N(Ra)C(O)ORa, -Rb-N(Ra)C(O)Ra, -Rb-N(Ra)S(O)tRa(where t is 1 or 2), -Rb-S(O)tRa(where t is 1 or 2), -Rb-S(O)tORa(where t is 1 or 2) and -Rb-S(O)tN(Ra)2(where t is 1 or 2); wherein each Rais independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, or heteroarylalkyl, wherein each Ra, valence permitting, may be optionally substituted with alkyl, alkenyl, alkynyl, halogen, haloalkyl, haloalkenyl, haloalkynyl, oxo (=0), thioxo (=S), cyano (-CN), nitro (-NO2), imino (=N-H), oximo (=N-0H), hydrazine (=N-NH2), -Rb-0Ra, -Rb-OC(O)-Ra, -Rb-0C(0)-0Ra, -Rb-OC(O)-N(Ra)2, - Rb-N(Ra)2, -Rb-C(0)Ra, -Rb-C(O)ORa, -Rb-C(0)N(Ra)2, -Rb-0-Rc-C(0)N(Ra)2, -Rb-N(Ra)C(0)0Ra, - Rb-N(Ra)C(O)Ra, -Rb-N(Ra)S(O)tRa(where t is 1 or 2), -Rb-S(O)tRa(where t is 1 or 2), -Rb-S(O)tORa(where t is 1 or 2) and -Rb-S(O)tN(Ra)2(where t is 1 or 2); and wherein each Rbis independently selected from a direct bond or a straight or branched alkylene, alkenylene, or alkynylene chain, and each Rcis a straight or branched alkylene, alkenylene or alkynylene chain.

[0058] Double bonds to oxygen atoms, such as oxo groups, are represented herein as both “=O” and “(O)”. Double bonds to nitrogen atoms are represented as both “=NR” and “(NR)”. Double bonds to sulfur atoms are represented as both “=S” and “(S)”.

[0059] The phrases “parenteral administration” and “administered parenterally” as used herein means modes of administration other than enteral and topical administration, usually by injection, and includes, without limitation, intravenous, intramuscular, intra-arterial, intrathecal, intracapsular, intraorbital, intracardiac, intradermal, intraperitoneal, transtracheal, subcutaneous, subcuticular, intraarticular, subcapsular, subarachnoid, intraspinal and intrasternal injection and infusion.

[0060] The phrase “pharmaceutically acceptable” is employed herein to refer to those compounds, materials, compositions, and / or dosage forms which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of human beings and animals without excessive toxicity, irritation, allergic response, or other problem or complication, commensurate with a reasonable benefit / risk ratio.

[0061] The phrase “pharmaceutically acceptable excipient” or “pharmaceutically acceptable carrier” as used herein means a pharmaceutically acceptable material, composition or vehicle, such as a liquid or solid filler, diluent, excipient, solvent or encapsulating material. Each carrier must be “acceptable” in the sense of being compatible with the other ingredients of the formulation and not injurious to the patient. Some examples of materials which can serve as pharmaceutically acceptable carriers include: (1) sugars, such as lactose, glucose and sucrose; (2) starches, such as corn starch and potato starch; (3) cellulose, and its derivatives, such as sodium carboxymethyl cellulose, ethyl cellulose and cellulose acetate; (4) powdered tragacanth; (5) malt; (6) gelatin; (7) talc; (8) excipients, such as cocoa butter and suppository waxes; (9) oils, such as peanut oil, cottonseed oil, safflower oil, sesame oil, olive oil, com oil and soybean oil; (10) glycols, such as propylene glycol; (11) polyols, such as glycerin, sorbitol, mannitol and polyethylene glycol; (12) esters, such as ethyl oleate and ethyl laurate; (13) agar; (14) buffering agents, such as magnesium hydroxide and aluminum hydroxide; (15) alginic acid; (16) pyrogen-free water; (17) isotonic saline; (18) Ringer's solution;(19) ethyl alcohol; (20) phosphate buffer solutions; and (21) other non-toxic compatible substances employed in pharmaceutical formulations.

[0062] The term “salt” or “pharmaceutically acceptable salt” refers to salts derived from a variety of organic and inorganic counter ions well known in the art. Pharmaceutically acceptable acid addition salts can be formed with inorganic acids and / or organic acids. Inorganic acids from which salts can be derived include, for example, hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid, and the like. Organic acids from which salts can be derived include, for example, acetic acid, propionic acid, glycolic acid, pyruvic acid, oxalic acid, maleic acid, malonic acid,succinic acid, fumaric acid, tartaric acid, citric acid, benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid, salicylic acid, and the like. Pharmaceutically acceptable base addition salts can be formed with inorganic and / or organic bases Inorganic bases from which salts can be derived include, for example, sodium, potassium, lithium, ammonium, calcium, magnesium, iron, zinc, copper, manganese, aluminum, and the like. Organic bases from which salts can be derived include, for example, primary, secondary, and tertiary amines, substituted amines including naturally occurring substituted amines, cyclic amines, basic ion exchange resins, and the like, specifically such as isopropyl amine, trimethylamine, diethylamine, triethylamine, tripropylamine, and ethanolamine. In some embodiments, the pharmaceutically acceptable base addition salt is selected from ammonium, potassium, sodium, calcium, and magnesium salts.

[0063] As used herein, “treatment” or “treating” refers to an approach for obtaining beneficial or desired results with respect to a disease, disorder, or medical condition including but not limited to a therapeutic benefit and / or a prophylactic benefit. A therapeutic benefit can include, for example, the eradication or amelioration of the underlying disorder being treated. Also, a therapeutic benefit can include, for example, the eradication or amelioration of one or more of the physiological symptoms associated with the underlying disorder such that an improvement is observed in the subject, notwithstanding that the subject may still be afflicted with the underlying disorder. In certain embodiments, for prophylactic benefit, the compositions are administered to a subject at risk of developing a particular disease, or to a subject reporting one or more of the physiological symptoms of a disease, even though a diagnosis of this disease may not have been made. Treatment via administration of a compound described herein does not require the involvement of a medical professional.

[0064] Chemical entities having carbon-carbon double bonds or carbon-nitrogen double bonds may exist in Z- or E- form (or cis- or trans- form). Furthermore, some chemical entities may exist in various tautomeric forms. Unless otherwise specified, all structures described herein are intended to disclose, implicitly or explicitly, all Z-, E- and tautomeric forms as well.

[0065] A “tautomer” refers to a molecule wherein a proton shift from one atom of a molecule to another atom of the same molecule is possible. The compounds presented herein, in certain embodiments, exist as tautomers. In circumstances where tautomerization is possible, a chemical equilibrium of the tautomers will exist. The exact ratio of the tautomers depends on several factors, including physical state, temperature, solvent, and pH. Some examples of tautomeric equilibria include, but are not limited to:

[0066] The compounds disclosed herein, in some embodiments, are used in different enriched isotopic forms, e.g., enriched in the content of2H,3H, "C,13C and / or14C. In one particular embodiment, the compound is deuterated in at least one position. Such deuterated forms can be made by the procedure described in U.S. Patent Nos. 5,846,514 and 6,334,997. As described in U.S. Patent Nos. 5,846,514 and 6,334,997, deuteration can improve the metabolic stability and or efficacy of drugs, thus increasing the duration of action of drugs.

[0067] Unless otherwise stated, compounds described herein are intended to include compounds which differ only in the presence of one or more isotopically enriched atoms. For example, compounds having the present structures except for the replacement of one or more proton(s) by one or more deuterium(deuteria) or tritium(tritia), or combinations thereof, or except for the replacement of one or more12C atom(s) in the structure by one or more13C atom(s), one or more14C atom(s), or combinations thereof, in the structure are within the scope of the present disclosure.

[0068] The compounds of the present disclosure optionally comprise unnatural proportions of atomic isotopes at one or more atom(s) that constitute such compounds. For example, the compounds may be labeled with one or more isotope(s), such as for example, deuterium (2H), tritium (3H), iodine-125 (125I) or carbon-14 (14C). Isotopic substitution with2H,3H,nC,13C,14C,15C,12N,13N,15N,16N,17O,18O,14F,15F,16F,17F,18F,33S,34S,35S,36S,35C1,37C1,79Br,81Br, and125I are all contemplated. All isotopic variations of the compounds of the present invention, whether radioactive or not, are encompassed within the scope of the present invention.

[0069] In certain embodiments, the compounds disclosed herein have some or all of the1H atoms replaced with2H atoms. The methods of synthesis for deuterium-containing compounds are known in the art and include, by way of non-limiting example only, the following synthetic methods.

[0070] Deuterium-substituted compounds are synthesized using various methods such as described in: Dean, Dennis C.; Editor. Recent Advances in the Synthesis and Applications of Radiolabeled Compounds for Drug Discovery and Development. [In: Curr., Pharm. Des., 2000; 6(10)] 2000, 110 pp; George W.; Varma, Rajender S. The Synthesis of Radiolabeled Compounds via Organometallic Intermediates, Tetrahedron, 1989, 45(21), 6601-21; and Evans, E. Anthony. Synthesis of radiolabeled compounds, J. Radioanal Chem., 1981, 64(1-2), 9-32.

[0071] Deuterated starting materials are readily available and are subjected to the synthetic methods described herein to provide for the synthesis of deuterium-containing compounds. Large numbers of deuterium-containing reagents and building blocks are available commercially from chemical vendors, such as MilliporeSigma.

[0072] Included in the present disclosure are salts, particularly pharmaceutically acceptable salts, of the compounds described herein. The compounds of the present disclosure that comprise one or more sufficiently acidic functional group(s), one or more sufficiently basic functional group(s), or both one or more sufficiently acidic functional group(s) and one or more sufficiently basic functional group(s) to form a salt (particularly a pharmaceutically acceptable salt), can react with any of a number of inorganic organic bases or inorganic or organic acids, to form a salt. ; combinations thereof); or combinations thereof. Alternatively, compounds that are inherently charged, such as those with a quaternary nitrogen, can form a salt with an appropriate counterion.

[0073] The compounds and salts described herein may in some cases exist as diastereomers, enantiomers, or other stereoisomeric forms. Unless otherwise specified (e.g., in tables of biological data), the structures disclosed herein are intended to include, explicitly or implicitly, disclosure of all diastereomeric (e g., epimeric) and enantiomeric forms as well as mixtures thereof. Separation of stereoisomers may be performed by chromatography or by forming diastereomers and separating by recrystallization, or chromatography, or any combination thereof. (Jean Jacques, Andre Collet, Samuel H. Wilen, “Enantiomers, Racemates and Resolutions”, John Wiley And Sons, Inc., 1981, herein incorporated by reference for this disclosure). Stereoisomers may also be obtained by stereoselective synthesis.

[0074] In certain embodiments, the compounds or salts of the compounds may be prodrugs. For example, in some embodiments, a hydroxyl in the parent compound is presented as an ester or a carbonate, or carboxylic acid present in the parent compound is presented as an ester. The term “prodrug” is intended to encompass compounds which, under physiologic conditions, are converted into pharmaceutical agents of the present disclosure. One method for making a prodrug is to include one or more selected moieties which are hydrolyzed under physiologic conditions to reveal the desired molecule. In other embodiments, the prodrug is converted by an enzymatic activity of thehost animal such as specific target cells in the host animal. For example, esters or carbonates (e.g., esters or carbonates of alcohols or carboxylic acids and esters of phosphonic acids) may be prodrugs of the present disclosure. In some embodiments, a prodrug for an amine might rely on enzymatic activation. In some embodiments, a prodrug for an amine might rely on physiological chemical conditions for release of the drugs. In some embodiments, a prodrug for an amine may be selected from an amide, a carbonate, an N-acyloxy alkyl derivative, an N-acyloxy carbonyl derivative, a betaaminoketone, an (oxodioxolenyl)methyl derivative, an N-Mannich base, an imine (e.g., a Schiff base), an enamine, an enaminone, an azo compound, a system capable of undergoing lactonization, a tetrahydrothiadiazine-2-thione, a redox system, or a PEG.

[0075] Prodrug forms of the herein described compounds, wherein the prodrug is metabolized in vivo to produce a compound as set forth herein are included within the scope of the claims. In some cases, some of the herein-described compounds may be a prodrug for another derivative or active compound.

[0076] Prodrugs are often useful because, in some situations, they may be easier to administer than the parent drug. They may, for instance, be bioavailable by oral administration whereas the parent is not. Prodrugs may help enhance the cell permeability of a compound relative to the parent drug. The prodrug may also have improved solubility in pharmaceutical compositions over the parent drug. Prodrugs may be designed as reversible drug derivatives, for use as modifiers to enhance drug transport to site-specific tissues or to increase drug residence inside of a cell.

[0077] In some embodiments, the design of a prodrug increases the lipophilicity of the pharmaceutical agent. In some embodiments, the design of a prodrug increases the effective water solubility. See, e.g., Fedorak etal., Am. J. Physiol., 269:G210-218 (1995); McLoed etal., Gastroenterol, 106:405-413 (1994); Hochhaus et al., Biomed. Chrom., 6:283-286 (1992); J. Larsen and H. Bundgaard, Int. J. Pharmaceutics, 37, 87 (1987); I. Larsen et al., Int. J. Pharmaceutics, 47, 103 (1988); Sinkula et al., J. Pharm. Sci., 64:181-210 (1975); T. Higuchi and V. Stella, Pro-drugs as Novel Delivery Systems, Vol. 14 of the A.C.S. Symposium Series; and Edward B. Roche, Bioreversible Carriers in Drug Design, American Pharmaceutical Association and Pergamon Press, 1987, all incorporated herein for such disclosure). According to another embodiment, the present disclosure provides methods of producing the above-defined compounds. The compounds may be synthesized using conventional techniques. Advantageously, these compounds are conveniently synthesized from readily available starting materials.

[0078] Synthetic chemistry transformations and methodologies useful in synthesizing the compounds described herein are known in the art and include, for example, those described in R. Larock, Comprehensive Organic Transformations (1989); T. W. Greene and P. G. M.Wuts, Protective Groups in Organic Synthesis, 2d. Ed. (1991); L. Fieser and M. Fieser, Fieser and Fieser ’s Reagents for Organic Synthesis (1994); and L. Paquete, ed., Encyclopedia of Reagents for Organic Synthesis (1995).CompoundsThe following comprises a discussion of compounds and salts thereof that may be used in the methods of the disclosure. In some embodiments, the compounds and salts are described in Formulas (I), (I-A), (I-B), (I-C), (II), (II-A), (II-B), (III), (III-A), (III-C), (IV), (IV-A), (IV-C), (V), and (V-A).

[0079] In one aspect, disclosed herein is a compound represented by Formula (I-C):or a salt thereof, wherein:X1, X2, X3, and X4are each independently selected from C(RX), N, and N+(O );Ring A is a 5- to 15-membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, - N(R10b)C(O)R10b-C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =0, =S, =N(R10b), and -CN;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, - N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b-C(O)OR10b, -OC(O)R10b, - N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =0, =S, =N(R10b), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more R9b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, - SR10b, -N(R10h)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b-N(R10b)C(O)N(R10b)2, - OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, - NO2, =0, =S, =N(R10b), -CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, C3-io carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more R9b; each R1is independently selected from: hydrogen; halogen, -NO2, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, - N(R10a)C(O)R10a-N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, - N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, and -S(O)2R10a;Ci-6 alkyl, C4-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, - N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -C(O)OR10a, -OC(O)R10a, - N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -S(O)R10a, -S(O)2R10a, -NO2, =0, =S, =N(R10a), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9a; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, - SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, - OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, - NO2, =0, =S, =N(R10a), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R9a;R3and R4are each independently selected from: hydrogen, halogen, -OR10c, -SR10c, -N(R10c)2, -N02, and -CN; andCi-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, -N(R10c)2, -NO2, and -CN;R5and R6are each independently selected from: hydrogen, halogen, -OR10d, -SR10d, -N(R10d)2, -N02, and -CN;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, - N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d-C(O)OR10d, -OC(O)R10d, - N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -N02, =0, =S, =N(R10d), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9c; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, - SR10d, -N(R10d)2, -NO2, and -CN; orR5together with R6form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more R9c;R8is selected from: hydrogen; andC1.4 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -NO2, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle are optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -NO2, and -CN; each R9a, R9b, and R9cis independently selected from: halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g- N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, - S(O)R10g, -S(O)2R10g, -NO2, -O, =S, -N(RI Os), and -CN; andC1.3 alkyl, C2-3 alkenyl, and C2.3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, - N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g-N(R10g)C(O)N(R10g)2, - OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, - NO2, =0, =S, =N(R10g), and -CN; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-s haloalkyl; and each R10a, R10b, R10c, R10d, R10f, and R10gis independently selected from: hydrogen;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1.6 alkyl, -S-Ci-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-e haloalkyl; wherein when Ring A is a 5-membered heterocycle, then: R5and R6are each independently selected from: hydrogen, halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, and -CN;Ci-6 alkyl and C2-6 alkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, - N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d-C(O)OR10d, -OC(O)R10d, - N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, =0, =S, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9c; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, - SR10d, -N(R10d)2, -NO2, and -CN; orR5together with R6form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more R9c; and wherein when Ring A is a 6-membered heterocycle, and R8is optionally substituted Ci alkyl; then R8is selected from: Ci alkyl substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -NO2, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle are optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -NO2, and -CN.

[0080] In one aspect, disclosed herein is a compound represented by Formula (I):or a salt thereof, wherein:X1, X2, X3, and X4are each independently selected from C(RX) and N;Ring A is a 7- to 15-membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, - N(R10b)C(O)R10b-C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =0, =S, =N(R10b), and -CN;Ci-6 alkyl, C2.6 alkenyl, and C2.6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, - N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b-C(O)OR10b, -OC(O)R10b, - N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -N02, =0, =S, =N(R10b), -CN, C3-io carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -yl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R9b; each R1is independently selected from: hydrogen; halogen, -N02, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, - N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, - N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, and -S(O)2R10a;Ci-6 alkyl, C2-6 alkenyl, and C2.6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, - N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -C(O)OR10a, -OC(O)R10a, - N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -S(O)R10a, -S(O)2R10a, -N02, =0, =S, =N(R10a), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9a; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, - SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a-N(R10a)C(O)N(R10a)2, - OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -N02, =0, =S, =N(R10a), -CN, Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R9a; each R3and R4are independently selected from: hydrogen, halogen, -OR10c, -SR10c, -N(R10c)2, -NO2, and -CN; andCi-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, -N(R10c)2, -N02, and -CN; each R5and R6are independently selected from: hydrogen, halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, and -CN;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, - N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d-C(O)OR10d, -OC(O)R10d, - N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -N02, =0, =S, =N(R10d), -CN, C3-io carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9c; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, - SR10d, -N(R10d)2, -NO2, and -CN; orR5together with R6form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more R9c;R8is selected from: hydrogen; andCi-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -NO2, -CN, C3-io carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle are optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -NO2, and -CN; each R9a, R9b, and R9care independently selected from: halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g- N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, - S(O)R10g, -S(O)2R10g, -NO2, =0, =S, =N(R10g), and -CN; andC1.3 alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -eachhydrogen;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1.6 alkyl, -S-Ci-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-g haloalkyl.

[0081] In another aspect, disclosed herein is a compound of Formula (I) is represented by Formula (LA):or a salt thereof, wherein:X1, X2, X3, and X4are each independently selected from C(RX) and N;Ring A is a 7- to 15-membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, - N(R10b)C(O)R10b-C(O)OR10b, -OC(O)R10b, -NO2, =0, and -CN;Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, - N(R10b)C(O)R10b-C(O)OR10b, -OC(O)R10b, -N02, =0, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10h)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b-C(O)OR10b, -OC(O)R10b, - N02, =0, -CN; and Ci-6 alkyl optionally substituted with one or more R9b; each R1is independently selected from: hydrogen; halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N02, and -CN;Ci-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -N02, -CN, C3-10 carbocycle and 3- to 10- membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9a, andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, - SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N02, -CN; and Ci-6alkyl optionally substituted with one or more R9a; each R3and R4are independently selected from: hydrogen, halogen, -N02, -CN, Ci-6 alkyl and C1-6 haloalkyl; each R5and R6are independently selected from: hydrogen, halogen, -OR10d, -SR10d, -N(R10d)2, -N02, and -CN;Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N02, =0, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9c; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, - SR10d, -N(R10d)2, -N02, and -CN;R8is selected from: hydrogen; andCi-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -N02, and -CN; each R9a, R9b, and R9care independently selected from: halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, - N(R10g)C(O)R10g-C(O)OR10g, -OC(O)R10g, -N02, =0, and -CN;Ci-3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, - N(R10g)C(O)R10g-C(O)OR10g, -OC(O)R10g, -NO2, =0, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle; each R10a, R10b, R10c, R10d, R10f, and R10gare independently selected from: hydrogen, Ci-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the Ci-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, and -NH2

[0082] In another aspect, disclosed herein is a compound of Formula (I) is represented by Formulaor a salt thereof, wherein:X1, X2, X3, and X4are each independently selected from C(RX) and N;Ring A is a 7- to 15-membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10h)2, -NO2, =0, and -CN;Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -NO2, =0, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, - SR10b, -N(R10h)2, -C(0)Rlob, -C(O)N(R10b)2, -N02, =0, -CN; and Ci-6alkyl optionally substituted with one or more R9b; each R1is independently selected from: hydrogen; halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N02, and -CN;Ci-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -NO2, -CN, C3-10 carbocycle and 3- to 10- membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9a; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, N(R10a)2, -CN; and Ci-6 alkyl optionally substituted with one or more R9a; and each R3and R4are independently selected from: hydrogen, halogen, -NO2, -CN, Ci-6 alkyl and Ci-6 haloalkyl;R5is hydrogen; and R6is selected from:Ci-3 alkyl substituted with one or more substituents independently selected from C3-6 carbocycle and 3- to 6- membered heterocycle, wherein the C3-6 carbocycle and 3- to 6-membered heterocycle are each optionally substituted with halogen, -OR10d, -N(R10d)2, - CN, C1-3 alkyl, and C1-3 haloalkyl; andC4-6 alkyl optionally substituted with one or more substituents independently selected from C3-6 carbocycle and 3- to 6-membered heterocycle, wherein the C3-6 carbocycle and 3- to 6-membered heterocycle are each optionally substituted with halogen, -OR10d, -N(R10d)2, -CN, C1.3 alkyl, and C1.3 haloalkyl;R8is selected from: hydrogen; andCi-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10f, -N(R10f)2, and -CN; each R9a, R9b, and R9care independently selected from halogen, -OR10g, -CN, C1-3 alkyl, and C1-3 haloalkyl; each R10a, R10b, R10c, R10d, R10f, and R10gare independently selected from hydrogen, Ci-6 alkyl, and Ci-6 haloalkyl.

[0083] In another aspect, disclosed herein is a compound represented by Formula (II):or a salt thereof, wherein:X1, X2, X3, and X4are each independently selected from C(RX) and N;Ring A is a 5- to 15-membered bridged or spirocyclic heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, - N(R10b)C(O)R10b-C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =0, =S, =N(R10b), and -CN;Ci-6 alkyl, C2.6 alkenyl, and C2.6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, - N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b-C(O)OR10b, -OC(O)R10b, - N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -N02, =0, =S, =N(R10b), -CN, C3-io carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -yl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R9b; each R1is independently selected from: hydrogen; halogen, -N02, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, - N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, - N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, and -S(O)2R10a;Ci-6 alkyl, C2-6 alkenyl, and C2.6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, - N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -C(O)OR10a, -OC(O)R10a, - N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -S(O)R10a, -S(O)2R10a, -N02, =0, =S, =N(R10a), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9a; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, - SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a-N(R10a)C(O)N(R10a)2, - OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -N02, =0, =S, =N(R10a), -CN, Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R9a; each R3and R4are independently selected from: hydrogen, halogen, -OR10c, -SR10c, -N(R10c)2, -NO2, and -CN; andCi-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, -N(R10c)2, -N02, and -CN; each R5and R6are independently selected from: hydrogen, halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, and -CN;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, - N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d-C(O)OR10d, -OC(O)R10d, - N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -N02, =0, =S, =N(R10d), -CN, C3-io carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9c; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, - SR10d, -N(R10d)2, -NO2, and -CN; orR5together with R6form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more R9c;R8is selected from: hydrogen; andCi-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -NO2, -CN, C3-io carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle are optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -NO2, and -CN; each R9a, R9b, and R9care independently selected from: halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g- N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, - S(O)R10g, -S(O)2R10g, -NO2, =0, =S, =N(R10g), and -CN; andC1.3 alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -eachhydrogen;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1.6 alkyl, -S-Ci-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-g haloalkyl.

[0084] In another aspect, disclosed herein is a compound of Formula (II) is represented by Formula (ILA):or a salt thereof, wherein:X1, X2, X3, and X4are each independently selected from C(RX) and N;Ring A is a 5- to 15-membered bridged or spirocyclic heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, - N(R10b)C(O)R10b-C(O)OR10b, -OC(O)R10b, -NO2, =0, and -CN;Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, - N(R10b)C(O)R10b-C(O)OR10b, -OC(O)R10b, -N02, =0, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10h)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b-C(O)OR10b, -OC(O)R10b, - N02, =0, -CN; and Ci-6 alkyl optionally substituted with one or more R9b; each R1is independently selected from: hydrogen; halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N02, and -CN;Ci-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -N02, -CN, C3-10 carbocycle and 3- to 10- membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9a, andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, - SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N02, -CN; and Ci-6alkyl optionally substituted with one or more R9a; each R3and R4are independently selected from: hydrogen, halogen, -N02, -CN, Ci-6 alkyl and C1-6 haloalkyl; each R5and R6are independently selected from: hydrogen, halogen, -OR10d, -SR10d, -N(R10d)2, -N02, and -CN;Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N02, =0, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9c; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, - SR10d, -N(R10d)2, -N02, and -CN;R8is selected from: hydrogen; andCi-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -N02, and -CN; each R9a, R9b, and R9care independently selected from: halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, - N(R10g)C(O)R10g-C(O)OR10g, -OC(O)R10g, -N02, =0, and -CN;Ci-3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, - N(R10g)C(O)R10g-C(O)OR10g, -OC(O)R10g, -NO2, =0, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle; each R10a, R10b, R10c, R10d, R10f, and R10gare independently selected from: hydrogen, Ci-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the Ci-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, and -NH2

[0085] In another aspect, disclosed herein is a compound of Formula (II) is represented by Formulaor a salt thereof, wherein:X1, X2, X3, and X4are each independently selected from C(RX) and N;Ring A is a 5- to 15-membered bridged or spirocyclic heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -NO2, =0, and -CN;Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -NO2, =0, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, - SR10b, -N(R10h)2, -C(0)Rlob, -C(O)N(R10b)2, -N02, =0, -CN; and Ci-6alkyl optionally substituted with one or more R9b; each R1is independently selected from: hydrogen; halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N02, and -CN;Ci-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -NO2, -CN, C3-10 carbocycle and 3- to 10- membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9a; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, N(R10a)2, and -CN; and Ci-6 alkyl optionally substituted with one or more R9a; and each R3and R4are independently selected from: hydrogen, halogen, -NO2, -CN, Ci-6 alkyl and Ci-6 haloalkyl;R5is hydrogen; and R6is selected from:Ci-3 alkyl substituted with one or more substituents independently selected from C3-6 carbocycle and 3- to 6- membered heterocycle, wherein the C3-6 carbocycle and 3- to 6-membered heterocycle are each optionally substituted with halogen, -OR10d, -N(R10d)2, - CN, C1-3 alkyl, and C1-3 haloalkyl; andC4-6 alkyl optionally substituted with one or more substituents independently selected from C3-6 carbocycle and 3- to 6-membered heterocycle, wherein the C3-6 carbocycle and 3- to 6-membered heterocycle are each optionally substituted with halogen, -OR10d, -N(R10d)2, -CN, C1.3 alkyl, and C1.3 haloalkyl;R8is selected from: hydrogen; andCi-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10f, -N(R10f)2, and -CN; each R9a, R9b, and R9care independently selected from halogen, -OR10g, -CN, C1-3 alkyl, and C1-3 haloalkyl; each R10a, R10b, R10c, R10d, R10f, and R10gare independently selected from hydrogen, Ci-6 alkyl, and C1-6 haloalkyl.

[0086] In some embodiments, for a compound or salt of Formula (I), (I- A), (I-B), (I-C), (II), (II- A), or (II-B), Ring A is not. In some embodiments, for a compound or salt of Formula (I), (I-A), (I-B), (I-C), (II),

[0087] In some embodiments, for a compound or salt of Formula (I), (I- A), (I-B), (I-C), (II), (II- A), or (II-B)„ at least one of X1, X2, X3, or X4is N. In some embodiments, at least two of X1, X2, X3, or X4is N. In some embodiments, X1, X2, X3, and X4are each independently selected from C(R3), N, and N+(-O ). In some embodiments, X1, X2, X3, and X4are each independently selected from C(R3) and N. In some embodiments, X1, X2, X3, and X4are each independently selected from C(R3). In some embodiments, X1, X2, X3, and X4are each independently selected from C(H), C(halogen), and N. In some embodiments, X1, X2, X3, and X4are each independently selected from C(H) and C(halogen). In some embodiments, X1, is C(halogen); X2is C(halogen); X3is C(H), and X4is C(H). In some embodiments, X1, is C(H); X2is C(halogen); X3is C(H), and X4is C(H). In some embodiments, X1, is C(halogen); X2is C(H); X3is C(H), and X4is C(H). In some embodiments, X1, is C(H); X2is C(H); X3is C(halogen), and X4is C(H). In some embodiments, X3is C(H), and X4is C(H). In some embodiments, X1is selected from C(H) and C(halogen). In some embodiments, X2is selected from C(H) and C(halogen). In some embodiments, X3is selected from C(H) and C(halogen). In some embodiments, X4is selected from C(H) and C(halogen). In some embodiments, X1, X2, X3, and X4are each independently selected from C(H), C(F), and N. In some embodiments, X1, X2, X3, and X4are each independently selected from C(H) and C(F). In some embodiments, X1, is C(F); X2is C(F); X3is C(H), and X4is C(H). In some embodiments, X1, is C(H); X2is C(F); X3is C(H), and X4is C(H). In some embodiments, X1, is C(F); X2is C(H); X3is C(H), and X4is C(H). In some embodiments, X1, is C(H); X2is C(H); X3is C(F), and X4is C(H). In some embodiments, X3is C(H), and X4is C(H). In some embodiments, X1is selected from C(H) and C(F). In someembodiments, X2is selected from C(H) and C(F). In some embodiments, X3is selected from C(H) and C(F). In some embodiments, X4is selected from C(H) and C(F). In some embodiments, X4is C(H). In some embodiments, X3is C(H). In some embodiments, X2is C(H). In some embodiments, X1is C(H). In some embodiments, X4is not N. In some embodiments, at least one of X1, X2, X3, or X4is N, and no more than two of X1, X2, X3, and X4are N. In some embodiments, X1, X2, X3, and X4are each C(R'). In some embodiments, one of X1, X2, X3, or X4is N. In some embodiments, two of X1, X2, X3, and X4are N. In some embodiments, three of X1, X2, X3, and X4are N. In some embodiments, at least one of X1, X2, X3, or X4is C(R3). In some embodiments, at least two of X1, X2, X3, and X4are ClR1). In some embodiments, at least three of X1, X2, X3, and X4are C(R'). In some embodiments, three of X1, X2, X3, and X4are N. In some embodiments, one of X1, X2, X3, or X4is C(R1). In some embodiments, two of X1, X2, X3, and X4are C(R3). In some embodiments, three of X1, X2, X3, and X4are C(R1). In some embodiments, four of X1, X2, X3, and X4are C(R3). In some embodiments, X1is N. In some embodiments, X2is N. In some embodiments, X3is N. In some embodiments, X4is N. In some embodiments, X1is C(R3). In some embodiments, X2is C(R'). In some embodiments, X3is C(R3). In some embodiments, X4is C(R3). In some embodiments, X1is C(H). In some embodiments, X2is C(H). In some embodiments, X3is C(H). In some embodiments, X4is C(H). In some embodiments, X1is N, and X2, X3, and X4are C(R3). In some embodiments, X2is N, and X1, X3, and X4are C(R3). In some embodiments, X3is N, and X1, X2, and X4are C(R3). In some embodiments, X4is N, and X1, X2, and X3are C(R'). In some embodiments, X1is N, and X2, X3, and X4are C(H). In some embodiments, X2is N, and X1, X3, and X4are C(H). In some embodiments, X3is N, and X1, X2, and X4are C(H). In some embodiments, X4is N, and X1, X2, and X3are C(H).

[0088] In certain embodiments, for a compound or salt of Formula (I), (I-A), (I-B), (I-C), (II), (II- A), or (II-B), each R1is independently selected from: hydrogen; halogen, -NO2, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, - N(R10a)C(O)R10a-N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, - OC(O)R10a, -S(O)R10a, and -S(O)2R10a;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, - N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a-C(O)OR10a, -OC(O)R10a, - N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -S(O)R10a, -S(O)2R10a, -NO2, =0, =S, =N(R10a), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9a; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, - SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a-N(R10a)C(O)N(R10a)2, - OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =0, =S, =N(R10a), -CN, Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R9a.In some embodiments, for a compound or salt of Formula (I), (I- A), (I-B), (I-C), (II), (II- A), or (II- B), e.g., for a compound or salt of (I) or Formula (II), each R1is independently selected from: hydrogen; halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N02, and -CN; Ci-6alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10a, - SR10a, -N(R10a)2, -C(O)R10a, -N02, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9a; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, - SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N02, -CN; and Ci-g alkyl optionally substituted with one or more R9a. In some embodiments, each R1is independently selected from: hydrogen; halogen, - OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N02, and -CN; Ci-6alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, and -N(R10a)2; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, and -N(R10a)2. In some embodiments, each R1is independently selected from: hydrogen, halogen, -OR10a, -SR10a, - N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N02, and -CN; Ci-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10a, -N(R10a)2, and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -N(R10a)2, and -CN. In some embodiments, each R1is independently selected from: hydrogen, halogen, -OR10a, -SR10a, - N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -NO2, and -CN; and Ci-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, - C(O)N(R10a)2, -N02, and -CN. In some embodiments, each R1is independently selected from: hydrogen, halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N02, and -CN; and Ci-6alkyl, optionally substituted with one or more substituents independently selected from halogen, - OR10a, -N(R10a)2, and -CN. In some embodiments, each R1is independently selected from each R1isindependently selected from: hydrogen, halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, - C(O)N(R10a)2, -NO2, -CN, C1-6 alkyl, and Ci-6 haloalkyl. In some embodiments, each R1is independently selected from hydrogen, halogen, -OR10a, -N(R10a)2, -CN, C1-6 alkyl, and Ci-6 haloalkyl. In some embodiments, each R1is independently selected from hydrogen, F, -Cl, -OH, - NH2, -CN, -OMe, and -OCF3; and C1-3 alkyl optionally substituted with one or more substituents independently selected from -F and -Cl. In some embodiments, each R1is independently selected from hydrogen, -F, -Cl, -OH, -NH2, and CN; and C1.3 alkyl optionally substituted with one or more substituents independently selected from -F and -Cl. In some embodiments, each R1is independently selected from hydrogen, halogen, -CN, methyl, and -CF3. In some embodiments, each R1is independently selected from hydrogen, -F, -Cl, -CN, methyl, and -CF3. In some embodiments, each R1is independently selected from: hydrogen, halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, - C(O)N(R10a)2, -NO2, and -CN. In some embodiments, each R1is independently selected from hydrogen, halogen, -OR10a, -N(R10a)2, and -CN. In some embodiments, each R1is independently selected from hydrogen, F, -Cl, -OH, -NH2, -CN, -OMe, and -OCF3. In some embodiments, each R1is independently selected from hydrogen, -F, -Cl, -OH, -NH2, and CN. In some embodiments, each R1is independently selected from hydrogen, halogen, and -CN. In some embodiments, each R1is independently selected from hydrogen, -F, -Cl, and CN. In some embodiments, each R1is independently selected from hydrogen and -CN. In some embodiments, each R1is independently selected from hydrogen and halogen. In some embodiments, each R1is independently selected from hydrogen, -F, and -Cl. In some embodiments, each R1is independently selected from hydrogen and - F. In some embodiments, each R1is hydrogen. In some embodiments, each R1is independently selected from hydrogen and Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10a, -N(R10a)2, -NO2, and -CN. In some embodiments, each R1is independently selected from hydrogen and Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10a, -N(R10a)2, and -CN. In some embodiments, each R1is independently selected from hydrogen, Ci-6 alkyl, and Ci-6 haloalkyl. In some embodiments, each R1is independently selected from hydrogen, C1-3 alkyl, and C1-3 haloalkyl. In some embodiments, each R1is independently selected from hydrogen and C1-3 alkyl optionally substituted with -F and -Cl. In some embodiments, each R1is independently selected from hydrogen, halogen, and methyl. In some embodiments, each R1is independently selected from hydrogen, fluoro, and methyl. In some embodiments, each R1is independently selected from hydrogen and methyl. In some embodiments, a compound or salt of each R1is inddependently selected from hydrogen, C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -N(R10a)2, -CN, Ci-6 alkyl, and Ci-6 haloalkyl. In some embodiments, each R1is inddependently selected from hydrogen, C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, Ci-6 alkyl, and Ci-6 haloalkyl. In some embodiments, each R1is inddependently selected from hydrogen, C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, and C1.3 alkyl optionally substituted with one or more substituents independently selected from -F and -Cl.

[0089] In some embodiments, for a compound or salt of Formula (I), (I- A), (I-B), (I-C), (II), (II- A), or (II-B), Ring A is a 3 - to 25-membered heterocycle, 5- to 20-membered heterocycle, 6- to 20- membered heterocycle, 7- to 20-membered heterocycle, 5- to 15-membered heterocycle, 6- to 15- membered heterocycle, 7- to 15-membered heterocycle, 5- to 20-membered heterocycloalkyl, 6- to 20-membered heterocycloalkyl, 7- to 20-membered heterocycloalkyl, 5- to 15-membered heterocycloalkyl, 6- to 15-membered heterocycloalkyl, 7- to 15-membered heterocycloalkyl, 5- to 20-membered heterocycloalkenyl, 6- to 20-membered heterocycloalkenyl, 5- to 20-membered bridged heterocycloalkyl, 7- to 20-membered heterocycloalkenyl, 5- to 15-membered heterocycloalkenyl, 6- to 15-membered heterocycloalkenyl, 7- to 15-membered heterocycloalkenyl, a 6- to 20-membered bridged heterocycloalkyl, a 7- to 20-membered bridged heterocycloalkyl, 5- to 15-membered bridged heterocycloalkyl, a 6- to 15-membered bridged heterocycloalkyl, a 7- to 15- membered bridged heterocycloalkyl, 5- to 20-membered bridged heterocycloalkenyl, 6- to 20- membered bridged heterocycloalkenyl, 7- to 20-membered bridged heterocycloalkenyl, 6- to 15- membered bridged heterocycloalkenyl, 7- to 15-membered bridged heterocycloalkenyl, 5- to 15- membered bridged heterocycloalkenyl, 7- to 14-membered bridged heterocycloalkenyl, 7- to 13- membered bridged heterocycloalkenyl, 7- to 12-membered bridged heterocycloalkenyl, 7- to 11- membered bridged heterocycloalkenyl, 7- to 10-membered bridged heterocycloalkenyl, 7- to 9- membered bridged heterocycloalkenyl, 7- to 8-membered bridged heterocycloalkenyl, 7-membered bridged heterocycloalkenyl, 6- to 12-membered bridged heterocycloalkenyl, a 6- to 10-membered bridged heterocycloalkenyl, 6- to 8-membered bridged heterocycloalkenyl, 5- to 20-membered spiro heterocycloalkyl, 6- to 20-membered spiro heterocycloalkyl, 7- to 20-membered spiro heterocycloalkyl, 5- to 15-membered spiro heterocycloalkyl, 6- to 15-membered spiro heterocycloalkyl, 7- to 15-membered spiro heterocycloalkyl, 7- to 12-membered spiro heterocycloalkyl, 6- to 10-membered spiro heterocycloalkyl, 7- to 20-membered spiro heterocycloalkenyl, 5- to 15-membered spiro heterocycloalkenyl, 5- to 20-membered spiro heterocycloalkenyl, a 6- to 20-membered spiro heterocycloalkenyl, 7- to 15 -membered spiroheterocycloalkenyl, or 6- to 15-membered spiro heterocycloalkenyl, each of which is optionally substituted.

[0090] In some embodiments, Ring A is comprises only 1 nitrogen atom as a member of the ring and no other heteroatoms as members of the ring (e.g., all other atoms that are members of the ring are carbon). In some embodiments, Ring A is comprises only 2 nitrogen atoms as a member of the ring and no other heteroatoms as members of the ring.

[0091] In some embodiments, for a compound or salt of Formula (I), (I- A), (I-B), (I-C), (II), (II- A), or (II-B), Ring A is a 3 - to 20-membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, - N(R10b)C(O)R10b-C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =0, =S, =N(R10b), and -CN;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, - N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b-C(O)OR10b, -OC(O)R10b, - N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, O, =S, =N(R10b), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more R9b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, - SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b-N(R10b)C(O)N(R10b)2, - OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10h, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, - NO2, =0, =S, =N(R10b), -CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, C3- 10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more R9b.

[0092] In some embodiments, Ring A is a 5 - to 20-membered heterocycle (e.g. 6- to 20-membered heterocycle, e.g. 7- to 20-membered heterocycle, e.g., 5- to 15-membered heterocycle, e.g., 6- to 15- membered heterocycle, e.g. 7- to 15-membered heterocycle) optionally substituted with one or more substituents independen-tly selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, - C(O)N(R10b)2, -N(R10b)C(O)R10b-C(O)OR10b, -OC(O)R10b, -NO2, =0, and -CN; Ci-6alkyl, C2.6alkenyl, and C2.6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b-C(O)OR10b, -OC(O)R10b, -N02, =0, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more R9b; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b-C(O)OR10b, -OC(O)R10b, - S(O)R10b, -S(O)2R10b, -N02, =0, -CN, Ci-6 alkyl, C2.6 alkenyl, C2.6 alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more R9b. In some embodiments, Ring A is a 5- to 20-membered heterocycle (e.g. 6- to 20-membered heterocycle, e g. 7- to 20-membered heterocycle, e.g., 5- to 15-membered heterocycle, e.g., 6- to 15-membered heterocycle, e.g. 7- to 15-membered heterocycle) optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -N02, =0, and -CN; Ci-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -N02, O, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more R9b; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10b, -SR10b, -N(R10b)2, -N02, =0, -CN, Ci-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each Ci-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more R9b. In some embodiments, Ring A is a 5- to 20-membered heterocycle (e.g. 6- to 20-membered heterocycle, e.g. 7- to 20-membered heterocycle, e g., 5- to 15- membered heterocycle, e.g., 6- to 15-membered heterocycle, e.g. 7- to 15-membered heterocycle) optionally substituted with one or more substituents independently selected from: halogen, -OR10b, - SR10b, -N(R10b)2, -C(O)R10b, -N02, =0, and -CN; Ci-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -N02, =0, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10- membered heterocycle is optionally substituted with one or more R9b; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -N02, =0, -CN, Ci-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each Ci-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more R9b. In some embodiments, Ring A is a 5- to 20-membered heterocycle (e.g. 6- to 20-membered heterocycle, e.g. 7- to 20- membered heterocycle, e.g., 5- to 15-membered heterocycle, e.g., 6- to 15-membered heterocycle, e.g. 7- to 15-membered heterocycle) optionally substituted with one or more substituentsindependently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, =0, and -CN; Ci-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10b, - SR10b, -N(R10b)2, =0, -CN, C3-io carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more R9b; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, =0, -CN, Ci-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each Ci-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more R9b. In some embodiments, Ring A is a 5- to 20-membered heterocycle (e g. 6- to 20-membered heterocycle, e.g. 7- to 20-membered heterocycle, e.g., 5- to 15-membered heterocycle, e.g., 6- to 15-membered heterocycle, e.g. 7- to 15-membered heterocycle) optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -N(R10b)2, -C(O)R10b, =0, and -CN; Ci-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, - OR10b, -N(R10b)2, 0, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more R9b; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -N(R10b)2, O, -CN, Ci-6 alkyl, C3- 10 carbocycle, and 3- to 10-membered heterocycle, wherein each Ci-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more R9b. In some embodiments, Ring A is a 5- to 20-membered heterocycle (e.g. 6- to 20-membered heterocycle, e.g. 7- to 20- membered heterocycle, e.g., 5- to 15-membered heterocycle, e.g., 6- to 15-membered heterocycle, e.g. 7- to 15-membered heterocycle) optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -N(R10b)2, -C(0)Rlob, =0, and -CN; Ci-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, =0, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10- membered heterocycle is optionally substituted with one or more substituents independently selected from halogen; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -N(R10b)2, =0, -CN, Ci-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each Ci-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more R9b. In some embodiments, Ring A is a 5- to 20-membered heterocycle (e.g. 6- to 20-membered heterocycle, e.g. 7- to 20-membered heterocycle, e.g., 5- to 15-membered heterocycle, e.g., 6- to 15- membered heterocycle, e.g. 7- to 15-membered heterocycle) optionally substituted with one or more substituents independently selected from: halogen, -CN, -OH, -0(Ci-6 alkyl), -0(Ci-6 haloalkyl), -SH, -S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, -C(O)R10b, and =0; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -0(Ci-6 alkyl), -0(Ci-6 haloalkyl), -SH, -S(Ci-6 alkyl), -NH2, -NH(Ci-6 alkyl), -N(Ci-6 alkyl)2, =0, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10- membered heterocycle is optionally substituted with one or more R9b; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -0(Ci-6 alkyl), -0(Ci-6 haloalkyl), -SH, -S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, =0, C1-6 alkyl, C3-10 carbocycle, and 3- to 10- membered heterocycle, wherein each C1-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more R9b. In some embodiments, Ring A is a 5- to 20-membered heterocycle (e.g. 6- to 20-membered heterocycle, e.g. 7- to 20-membered heterocycle, e.g., 5- to 15- membered heterocycle, e.g., 6- to 15-membered heterocycle, e.g. 7- to 15-membered heterocycle) optionally substituted with one or more substituents independently selected from: halogen, -CN, - OH, -O(Ci-6alkyl), -O(Ci-6haloalkyl), -NH2, -NH(CI-6alkyl), -N(CI-6alkyl)2, -C(O)R10b, and =0; Ci-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -O(Ci-6alkyl), -O(Ci-6haloalkyl), -NH2, -NH(CI-6alkyl), -N(CI-6alkyl)2, =0, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10- membered heterocycle is optionally substituted with one or more R9b; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -0(Ci-6 alkyl), -0(Ci-6 haloalkyl), -SH, -S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, =0, C1-6 alkyl, C3-10 carbocycle, and 3- to 10- membered heterocycle, wherein each C1-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more R9b. In some embodiments, Ring A is a 5- to 20-membered heterocycle (e.g. 6- to 20-membered heterocycle, e.g. 7- to 20-membered heterocycle, e g., 5- to 15- membered heterocycle, e.g., 6- to 15-membered heterocycle, e.g. 7- to 15-membered heterocycle) optionally substituted with one or more substituents independently selected from: halogen, -CN, - OH, -NH2, -C(O)(Ph), and =0; Ci-6 alkyl, optionally substituted with one or more substituents independently selected from =0, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more R9b; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -0(Ci-6 alkyl), -0(Ci-6 haloalkyl), -SH, -S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, =0, Ci-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, Ring A is a 5- to 20- membered (e.g. 6- to 20-membered heterocycle, e.g. 7- to 20-membered heterocycle, e g., 5- to 15-membered heterocycle, e.g., 6- to 15-membered heterocycle, e.g. 7- to 15-membered heterocycle) optionally substituted with one or more substituents independently selected from: halogen, -CN, - OH, -O(Ci.6 alkyl), -O(Ci_6haloalkyl), -SH, -S(Ci-6alkyl), -NH2, -NH(CI_6alkyl), -N(CI-6alkyl)2, -C(O)R10b, and =0. In some embodiments, Ring A is a 5- to 20-membered heterocycle (e.g. 6- to 20-membered heterocycle, e.g. 7- to 20-membered heterocycle, e.g., 5- to 15-membered heterocycle, e g., 6- to 15-membered heterocycle, e.g. 7- to 15-membered heterocycle) optionally substituted with one or more substituents independently selected from Ci-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -0(Ci-6 alkyl), -0(Ci-6 haloalkyl), -SH, -S(Ci-6 alkyl), -NH2, -NH(Ci-6 alkyl), -N(Ci-6 alkyl)2, =0, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10- membered heterocycle is optionally substituted with one or more R9b. In some embodiments, Ring A is a 5- to 20-membered heterocycle, (e.g. 6- to 20-membered heterocycle, e.g. 7- to 20-membered heterocycle, e.g., 5- to 15-membered heterocycle, e.g., 6- to 15-membered heterocycle, e.g. 7- to 15- membered heterocycle) optionally substituted with one or more substituents independently selected from Ci alkyl, optionally substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10- membered heterocycle is optionally substituted with one or more R9b. In some embodiments, Ring A is a 5- to 20-membered heterocycle, (e.g. 6- to 20-membered heterocycle, e.g. 7- to 20-membered heterocycle, e.g., 5- to 15-membered heterocycle, e.g., 6- to 15-membered heterocycle, e g. 7- to 15- membered heterocycle) optionally substituted with one or more substituents independently selected from Ci alkyl. In some embodiments, Ring A is a 5- to 20-membered heterocycle (e.g. 6- to 20- membered heterocycle, e.g. 7- to 20-membered heterocycle, e.g., 5- to 15-membered heterocycle, e.g., 6- to 15-membered heterocycle, e.g. 7- to 15-membered heterocycle) optionally substituted with one or more substituents independently selected from -F; -CH?; and C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -0(Ci-6 alkyl), -0(Ci-6 haloalkyl), -SH, -S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, =0, C1-6 alkyl, C3-10 carbocycle, and 3- to 10- membered heterocycle, wherein each C1-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more R9b. n some embodiments, Ring A is a 5- to 20-membered heterocycle (e.g. 6- to 20-membered heterocycle, e.g. 7- to 20-membered heterocycle, e g., 5- to 15- membered heterocycle, e.g., 6- to 15-membered heterocycle, e.g. 7- to 15-membered heterocycle) optionally substituted with one or more substituents independently selected from: -F and -CH?; and 2-pyridonyl, phenyl, pyridinyl, pyrimidinyl, pyridazinyl, and thiazolyl, each of which is optionally substituted with one or more substituents independently selected from -CH?, isopropyl, -CF3, -F, -CN, -OH, -0(CH3), -O(CF3), -O(zPr), =0,In some embodiments, Ring A is a 5- to 20-membered heterocycle (e.g. 6- to 20-membered heterocycle, e.g. 7- to 20-membered heterocycle, e.g., 5- to 15-membered heterocycle, e.g., 6- to 15-membered heterocycle, e.g. 7- to 15- membered heterocycle) optionally substituted with one or more substituents independently selected from: -NH2, -C(O)(Ph), and =0; Ci-6 alkyl, optionally substituted with one or more substituents independently selected from =0, C3-10 carbocycle, wherein each C3-10 carbocycle is optionally substituted with one or more R9b; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - CN, -OH, -O(Ci-6alkyl), -0(Ci-6 haloalkyl), =0, Ci-6 alkyl, Ci-e haloalkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, Ring A is a 5 - to 20-membered heterocycle (e.g.6- to 20-membered heterocycle, e.g. 7- to 20-membered heterocycle, e.g., 5- to 15-membered heterocycle, e.g., 6- to 15-membered heterocycle, e.g. 7- to 15-membered heterocycle) optionally substituted with one or more substituents independently selected from: -NH2, -C(O)(Ph), =0,, ; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -CH3, isopropyl,.

[0093] In some embodiments, Ring A is a 7- to 15-membered heterocycle optionally substituted with C3-10 carbocycle or 3- to 15-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, - C(O)N(R10b)2, -N(R10b)C(O)R10b-N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =0, =S, =N(R10b), -CN, Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more R9b. In some embodiments, Ring A is a 7- to 15-membered heterocycle optionally substituted with C3-10 carbocycle or 3- to 15-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b- N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =0, -CN, Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle isoptionally substituted with one or more R9b. In some embodiments, Ring A is a 7- to 15-membered heterocycle optionally substituted with C3-10 carbocycle or 3- to 15-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OH, -O(C 1-6 alkyl), -O(Ci-6 haloalkyl), -0(C3-io carbocycle), 0(3- to 10-membered heterocycle), - NH2, -N(Ci-6 alkyl)2, -N(C3-IO carbocycle)2, -NH(CI-6 alkyl), -NH(C3-IO carbocycle), -NH(3- to 10- membered heterocycle), -C(0)(Ci-6 alkyl), -C(0)( C3-10 carbocycle), -C(0)(3- to 10-membered heterocycle), -C(O)NH2, -C(O)NH(Ci-6 alkyl), -C(0)NH(C3-IO carbocycle), -C(O)NH(3- to 10- membered heterocycle), -C(O)N(Ci-6 alkyl)2, -C(0)N(C3-IO carbocycle)2, -NHC(0)(CI-6 alkyl), -N(Ci- 6 alkyl)C(0)(Ci-6 alkyl), -NHC(0)(C3-io carbocycle), -N(Ci-6 alkyl)C(0)(C3-io carbocycle), -N(CI-6 alkyl)C(O)N(Ci-6alkyl)2, -NHC(0)N(Ci-6alkyl)2, -N(CI-6alkyl)C(O)NH(Ci-6alkyl), - NHC(0)NH(CI-6alkyl), -NHC(0)NH(C3-io carbocycle), -0C(0)NH(Ci-6alkyl), -OC(0)NH(C3-IO carbocycle), -N(Ci-6 lkyl)C(O)O(Ci-6 alkyl), -N(Ci-6 lkyl)C(0)0(C3-io carbocycle), -N(C3-io carbocycle)C(O)O(Ci-6alkyl), -NHC(0)0(Ci-6alkyl), -NHC(0)0(C3-io carbocycle), -S(0)(C3-io carbocycle), -S(0)(Ci-6 alkyl), -S(O)2(Ci-6 alkyl), -8(0)2(63-10 carbocycle), -NO2, =0, -CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more R9b. In some embodiments, Ring A is a 7- to 15-membered heterocycle optionally substituted with C3-10 carbocycle or 3- to 15-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OH, -0(C 1-6 alkyl), -O(Ci-6haloalkyl), -NH2, -S(O)2(Ci-6alkyl), =0, -CN, Ci-6alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each Ci-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more R9b. In some embodiments, Ring A is a 7- to 15-membered heterocycle optionally substituted with C3-10 carbocycle optionally substituted with one or more substituents independently selected from halogen, -OH, -0(Ci-6 alkyl), - 0(C 1-6 haloalkyl), -NH2, -S(O)2(Ci-6 alkyl), =0, -CN, Ci-6 alkyl, C3-10 carbocycle, and 3- to 10- membered heterocycle, wherein each Ci-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more R9b. In some embodiments, Ring A is a 7- to 15-membered heterocycle optionally substituted with 3- to 15-membered heterocycle optionally substituted with one or more substituents independently selected from halogen, -OH, -0(Ci-6 alkyl), -0(Ci-6 haloalkyl), -NH2, -S(O)2(Ci-6 alkyl), =0, -CN, Ci-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each Ci-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more R9b. In some embodiments, Ring A is a 7- to 15-membered heterocycle optionally substituted with C3-10 carbocycle or 3- to 15-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from fluoro,chloro, bromo, iodo, -OH, -O(Ci-6 alkyl), -O(Ci-6 haloalkyl), -NH2, -S(O)2(C 1-6 alkyl), =0, -CN, Ci-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each Ci-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more R9b. In some embodiments, Ring A is a 7- to 15-membered heterocycle optionally substituted with C3-10 carbocycle or 3- to 15-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from fluoro, chloro, bromo, -OH, -0(Ci-3 alkyl), -0(Ci-3 haloalkyl), -NH2, -S(O)2(Ci-3 alkyl), =0, -CN, Ci-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each Ci-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more R9b. In some embodiments, Ring A is a 7- to 15-membered heterocycle optionally substituted with C3-10 carbocycle or 3- to 15-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from fluoro, chloro, bromo, -OH, -0(CH , -0(CF3), -NH2, -S(O)2(CH3), =0, -CN, Ci-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each Ci-6 alkyl, C3-10 carbocycle, and 3- to 10- membered heterocycle is optionally substituted with one or more R9b. In some embodiments, Ring A is a 7- to 15-membered heterocycle optionally substituted with C3-10 carbocycle or 3- to 15- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from fluoro, chloro, bromo, -OH, -©(CH?), -0(CF3), -NH2, -S(O)2(CH3), =0, -CN, Ci-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each Ci-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more halogen, Ci-3 alkyl, Ci-3 haloalkyl, -OH, -0(Ci-3 alkyl), -0(C 1-3 haloalkyl), C3-10 carbocycle, or 3- to 10- membered heterocycle. In some embodiments, Ring A is a 7- to 15-membered heterocycle optionally substituted with C3-10 carbocycle or 3- to 15-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -S(O)2(R10b). In some embodiments, Ring A is a 7- to 15-membered heterocycle optionally substituted with C3-10 carbocycle or 3- to 15-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -S(O)2(CH3).

[0094] In some embodiments, Ring A is, wherein w and x are each integers independently selected from 1, 2, 3, and 4; and Ring A is optionally substituted with one or more substituents independently selected from: -F; Ci-6 alkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10h, -C(O)N(R10b)2, -N(R10b)C(O)R10b-C(O)OR10b, - OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, - NO2, =0, =S, =N(R10b), and -CN; Ci-6 alkyl, C2-6 alkenyl, and C2-e alkynyl, each of which isoptionally substituted with one or more substituents independently selected from halogen, -OR10b, - SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b-C(O)OR10b, -OC(O)R10b, - N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =0, =S, =N(R10b), -CN, C3-io carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more R9b; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one orCi-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more R9b. In some embodiments, Ring A isvs0 , which is optionally substituted with one or more substituents independently selected from: -F; C1-6 alkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -CH3, isopropyl, -CF3, -F, -CN, -OH, -0(CH3), -optionally substituted with one or more substituents independently selected from R9b; and Ring A is optionally further substituted.

[0095] In some embodiments, (e.g., for a compound or salt of Formula (I), (I-A), (I-B), or (I-C),some embodiments, Ring A is a 7 to 15-membered bridged or spirocyclic heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, - N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b-C(O)OR10b, -OC(O)R10b, -NO2, =0, and -CN; Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10h, -C(O)N(R10b)2, -N(R10b)C(O)R10b-C(O)OR10b, - OC(O)R10b, -N02, =0, -CN, C3-io carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b-C(O)OR10b, -OC(O)R10b, -NO2, =0, -CN; and Ci-6alkyl optionally substituted with one or more R9b. In some embodiments, Ring A is a 7- to 15-membered bridged or spirocyclic heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N02, =0, and -CN; Ci-6alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10b, - SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N02, =0, and -CN; and C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(0)Rlob, -C(O)N(R10b)2, -N02, =0, -CN, Ci-6 alkyl, and Ci-6 haloalkyl. In some embodiments, a compound or salt Ring A is a 5- to 15-membered bridged or spirocyclic heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, - N(Rlob)C(0)Rlob-C(O)OR10b, -OC(O)R10b, -N02, =0, and -CN; Ci-6alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b,to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b-C(O)OR10b, -OC(O)R10b, -N02, =0, -CN; and Ci-6alkyl optionally substituted with one or more R9b. In some embodiments, Ring A is a 5- to 15-membered bridged or spirocyclic heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N02, =0, and -CN; Ci-6alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10b, -membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N02, =0, -CN, Ci-6 alkyl, and Ci-6 haloalkyl. In some embodiments, Ring A is a 7 to 12-membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N02, O, and -CN; Ci-6alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10b, - SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N02, =0, and -CN; and C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N02, =0, -CN, Ci-6 alkyl, and Ci-6 haloalkyl. In some embodiments, Ring A is a 7 to 12-membered bridged or spirocyclic heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N02, =0, and -CN; Ci- 6 alkyl optionally substituted with one or more substituents independently selected from halogen, - OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N02, =0, and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N02, =0, -CN, Ci-6 alkyl, and Ci-6 haloalkyl. In some embodiments, Ring A is a 7- to 12-membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -N(R10b)2, =0, and -CN; Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10b, -N(R10b)2, and -CN; and C3-6 carbocycle and 3- to 6-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -N(R10b)2, =0, -CN, Ci-6 alkyl, and Ci-6 haloalkyl. In some embodiments, Ring A is a 7- to 12-membered bridged or spirocyclic heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OR10b, - N(R10b)2, =0, and -CN; Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10b, -N(R10b)2, and -CN; and C3-6 carbocycle and 3- to 6-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -N(R10b)2, =0, -CN, Ci-6 alkyl, and Ci-6 haloalkyl. In someembodiments, Ring A is a 7- to 12-membered heterocycle optionally substituted with one or more substituents independently selected from halogen, -OR10b, -N(R10b)2, =0, -CN, Ci-6 alkyl, and Ci-6 haloalkyl, and C3-6 carbocycle and 3- to 6-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen -OR10b, -N(R10b)2, =0, -CN, Ci-6 alkyl, and Ci-6 haloalkyl. In some embodiments, Ring A is a 7- to 12-membered bridged or spirocyclic heterocycle optionally substituted with one or more substituents independently selected from halogen, -OR10b, -N(R10b)2, =0, -CN, Ci-6 alkyl, and Ci-6 haloalkyl; and C3-6 carbocycle and 3- to 6-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen -OR10b, -N(R10b)2, =0, -CN, Ci-6 alkyl, and Ci-6 haloalkyl. In some embodiments, Ring A is a 7- to 12-membered bridged or spirocyclic heterocycle optionally substituted with one or more substituents independently selected from: -F, - OH, -N(H)2, =0, -CN; and C1-3 alkyl optionally substituted with one or more substituents independently selected from -F and -Cl; and C3-6 carbocycle and 3- to 6-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -OH, - N(H)2, =0, and -CN; and C1-3 alkyl optionally substituted with one or more substituents independently selected from -F and -Cl. In some embodiments, Ring A is a 7- to 12-membered bridged or spirocyclic heterocycle optionally substituted with one or more substituents independently selected from: -OH, -NH2, =0, methyl, C3-6 carbocycle and 3- to 6-membered heterocycle, wherein the C3-6 carbocycle and 3- to 6-membered heterocycle are each optionally substituted with one or more substituents independently selected from -OH, -NH2, =0, and methyl. In some embodiments,

[0096] In some embodiments, for a compound or salt of Formula (I), (I- A), (I-B), (I-C), (II), (II- A), or (II-B), e.g., for a compound or salt of Formula (I) or Formula (II), R3and R4are each independently selected from hydrogen, halogen, -OR10c, -SR10c, -N(R10c)2, -NO2, and -CN; and Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, - OR10c, -SR10c, -N(R10C)2, -NO2, and -CN. In some embodiments, R3and R4are each independently selected from hydrogen, halogen, -OR10c, -N(R10c)2, -NO2, and -CN; and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10c, -N(R10c)2, - NO2, and -CN. In some embodiments, R3and R4are each independently selected from: hydrogen, halogen, -NO2, -CN, C1-6 alkyl and Ci-6 haloalkyl. In some embodiments, R3and R4are each independently selected from: hydrogen, halogen, Ci-6 alkyl and Ci-6 haloalkyl. In some embodiments, R3and R4are each independently selected from: hydrogen, Ci-6 alkyl and Ci-6 haloalkyl. In some embodiments, R3and R4are each independently selected from hydrogen and Ci-6 alkyl. In some embodiments, R3and R4are each independently selected from: hydrogen and methyl. In some embodiments, R3and R4are each hydrogen. In some embodiments, R3is hydrogen. In some embodiments, R4is hydrogen. In some embodiments, R3is -OH, and R4is -H.

[0097] In some embodiments, for a compound or salt of Formula (I), (I- A), (I-B), (I-C), (II), (II- A), or (II-B), e.g., for a compound or salt of Formula (I) or Formula (II), R5and R6are each independently selected from: hydrogen, halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, and -CN;Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -NO2, =0, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10- membered heterocycle are each optionally substituted with one or more R9c; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, - SR10d, -N(R10d)2, -NO2, and -CN; or R5together with R6form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more R9c.

[0098] In some embodiments, for a compound or salt of Formula (I), (I- A), (I-B), (I-C), (II), (II- A), or (II-B), e.g., for a compound or salt of Formula (I) or Formula (II), wherein R5and R6are each independently selected from: hydrogen, halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, and -CN; Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10d, - SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -NO2, =O, -CN, C3-10 carbocycle and 3- to 10-memberedheterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9c; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10d, -SR10d, -N(R10d)2, -NO2, and -CN. In some embodiments, for a compound or salt of Formula (I), (I- A), (I-B), (I-C), (II), (II- A), or (II-B), , e.g., for a compound or salt of Formula (I) or (II), R5and R6are each independently selected from: hydrogen, halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, and -CN;C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle are optionally substituted with one or more substituents independently selected from halogen, -OR10d, - SR10d, -N(R10d)2, -NO2, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, - SR10d, -N(R10d)2, -NO2, and -CN.

[0099] In some embodiments, for a compound or salt of Formula (I), (I- A), (I-B), (I-C), (II), (II- A), or (II-B), e.g., for a compound or salt of Formula (I) or (II), R5and R6are each independently selected from hydrogen, halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, and -CN; and C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, - N(R10d)2, -NO2, -CN, C3-io carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle are optionally substituted with one or more substituents independently selected from halogen, -OR10d, -N(R10d)2, -NO2, and -CN. In some embodiments, each R5and R6are each independently selected from: hydrogen, halogen, -OR10d, - N(R10d)2, -NO2, -CN, Ci-6 alkyl, and C1-6 haloalkyl. In some embodiments, each R5and R6are each independently selected from: hydrogen, halogen, -OR10d, -CN, C1-3 alkyl, and C1.3 haloalkyl. In some embodiments, each R5and R6are each independently selected from: hydrogen, -F, -Cl, -OH, and - CN; and C1-3 alkyl optionally substituted with one or more substituents independently selected from - F and -Cl. In some embodiments, each R5and R6are each independently selected from: hydrogen, - F, -Cl, -OH, -CN, and methyl. In some embodiments, R5and R6are hydrogen. In some embodiments, R5is hydrogen. In some embodiments, R6is hydrogen. In some embodiments, R5is selected from hydrogen, halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, and -CN; and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, - N(R10d)2, -NO2, =0, and -CN; and R6is selected from: C1-3 alkyl substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle,wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9c; and C4-6 alkyl optionally substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9c. In some embodiments, R5is hydrogen; and R6is selected from: C1.3 alkyl substituted with one or more substituents independently selected from C3-6 carbocycle and 3- to 6- membered heterocycle, wherein the C3-6 carbocycle and 3- to 6-membered heterocycle are each optionally substituted with halogen, -OR10d, -N(R10d)2, -CN, C1-3 alkyl, and C1.3 haloalkyl; and C4-6 alkyl optionally substituted with one or more substituents independently selected from C3-6 carbocycle and 3- to 6-membered heterocycle, wherein the C3-6 carbocycle and 3- to 6-membered heterocycle are each optionally substituted with halogen, -OR10d, -N(R10d)2, -CN, C1-3 alkyl, and C1-3 haloalkyl. In some embodiments, R5is hydrogen; and R6is selected from: C1.3 alkyl substituted with one or more substituents independently selected from C3-6 carbocycle and 3- to 6- membered heterocycle, wherein the C3-6 carbocycle and 3- to 6-membered heterocycle are each optionally substituted with - F, -Cl, -OH, -NH2, -CN; and C1-3 alkyl optionally substituted with one or more substituents independently selected from -F and -Cl; and C4-6 alkyl optionally substituted with one or more substituents independently selected from C3-6 carbocycle and 3- to 6-membered heterocycle, wherein the C3-6 carbocycle and 3- to 6-membered heterocycle are each optionally substituted with -F, -Cl, - OH, -NH2, -CN; and C1-3 alkyl optionally substituted with one or more substituents independently selected from -F and -Cl. In some embodiments, R5is hydrogen; and R6is selected from C4-6 alkyl; and Ci alkyl substituted with C3-6 carbocycle or 3- to 6-membered heterocycle. In some embodiments, R5is hydrogen, and R6is selected from C4 alkyl and Ci alkyl substituted with C3-61 Q carbocycle. In some embodiments, R5is hydrogen; and R6is selected from —I— and -J—

[0100] In some embodiments, R5is selected from: hydrogen; halogen, -C(O)R10d, - C(O)N(R10d)2, -C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, -N3, and -CN; Cn6alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, - N(R10d)C(O)R10d-C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, - N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, =0, =S, =N(R10d), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9c; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d-N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, - S(O)2R10d, -N02, =0, =S, =N(R10d), -N3, -CN, Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein Ci-6 alkyl, C2.6 alkenyl, and C2.6 alkynyl are each optionally substituted with one or more R9c. In some embodiments, R5is selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, - N(R10d)C(O)R10d-C(O)OR10d, -OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, - N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -N02, -N3, and -CN; Cn6alkyl, C2.6alkenyl, and C2.6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d-C(O)OR10d, - OC(O)R10d, -N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, - N02, =0, =S, =N(R10d), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9c; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d- N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, - S(O)2R10d, -N02, =0, =S, =N(R10d), -N3, -CN, Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each Ci-6 alkyl, C2-6 alkenyl, and C2.g alkynyl is optionally substituted with one or more substituents independently selected from R9c; or R5together with R6form a 3 - to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9c. In some embodiments, R5is selected from: Ci alkyl, substituted with one or more substituents independently selected from: C3- 10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10- membered heterocycle is optionally substituted with one or more substituents independently selected from fluoro, -OH, -O( / Bu), Ci alkyl, C4 alkyl (e.g., -tBu), and -CF3. In some embodiments, R5is selected from: Ci alkyl, substituted with one substituent selected from: C3-10 carbocycle and 3- to 10- membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from fluoro, -OH, - O( / Bu), Ci alkyl, -tBu, and -CF3. In some embodiments, R5is selected from: Ci alkyl, substituted with one or more substituents independently selected from: phenyl, pyridyl (e.g., 2-pyridyl, 3- pyridyl, or 4-pyridyl), cyclopropyl, cyclobutyl, tetrahydropyranyl (e.g., 4- tetrahydropyranyl),mopholino (e.g., JV-morpholino), and [l. l . l]-bicyclopentyl (e g., 1-[1. 1.1]- bicyclopentyl), imidazolyl (e.g., 5-imidazolyl), thiophenyl (e.g., 2-thiophenyl), thiazolyl (e.g., 4- thiazolyl), indolyl (e.g., 2-indolyl, 3-indolyl), bicyclo[2.2.1]heptyl (e.g., 1- bicyclo[2.2.1]heptyl), azabicyclo[2.2.1]heptanyl (e.g., 7-azabicyclo[2.2.1]heptanyl, e.g., 1- 7-azabicyclo[2.2.1]heptanyl),azabicyclo[2.2.2]octanyl (e.g., 2-azabicyclo[2.2.2]octanyl, e.g., 4-2-azabicyclo[2.2.2]octanyl), oxabicyclo[2.2.1]heptanyl (e.g., 7-oxabicyclo[2.2.1]heptanyl. e.g., 13-7-oxabicyclo[2.2.1]heptanyl), oxabicyclo[2.2.2]octanyl, (e g., 2-oxabicyclo[2.2 2]octanyl, e g., 13-2-oxabicyclo[2.2.2]octanyl), oxa-azabicyclo[3.2.1]octanyl (e.g., 8-oxa-3-azabicyclo[3.2.1]octanyl, e.g., 13-8-oxa-3- azabicyclo[3.2.1]octanyl, e.g., 3-oxa-8-azabicyclo[3.2.1]octanyl), any of which is optionally substituted (e g , optionally substituted with one or more R9c. In some embodiments, R5is selectedfurther substituted) (e.g., optionally substituted with, e.g., optionally further substituted with, one or more substituents independently selected from R9c). In some embodiments, R5is selected from:Ci-io alkyl, optionally substituted with one or more substituents independently selected from halogen, - OR10d, -SR10d, -N(R10d)2, =0, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9c. In some embodiments, R5is a methyl, ethyl, n-propyl, i-propyl, n-butyl, s-butyl, i-butyl, t-butyl, n-pentyl, tert-pentyl, neopentyl, isopentyl, sec-pentyl, 3- pentyl, sec-isopentyl, or 2-methylbutyl moiety, each of which is optionally substituted, e.g., with one or more substituents independently selected from R9c. In some embodiments, R5is selected from: C3- 10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one orCN, Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9c. In some embodiments, R5is selected from: C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10d, -SR10d, -N(R10d)2, =0, -CN, and Ci-6 alkyl, wherein each Ci-6 alkyl is optionally substituted with one or more substituents independently selected from R9c. In some embodiments, R5is [1.1.1]- bicyclopentyl (e.g., l-[l . l .l]bicyclopentyl), cyclopentyl, cyclohexyl, tetrahydropyranyl (e.g., 4- tetrahydropyranyl), bicyclo[2.2.1]heptyl (e.g., 1- bicyclo[2.2.1]heptyl), 7-azabicyclo[2.2.1]heptanyl (e.g., 1- 7-azabicyclo[2.2.1]heptanyl), 2-azabicyclo[2.2.2]octanyl (e g., 4-2- azabicyclo[2.2.2]octanyl), or 2-oxabicyclo[2.2.2]octanyl (e.g., 13-2-oxabicyclo[2.2.2]octanyl). In some embodiments, R5is selected from:, , each of which is optionally substituted(e.g. optionally further substituted) (e.g., optionally substituted with, e.g., optionally further substituted with, one or more substituents independently selected from R9c). In some embodiments,is optionally substituted (e.g., optionally substituted with one or more substituents independently selected from: R9c).

[0101] In some embodiments, for a compound or salt of Formula (I), (I-A), (I-B), (I-C), (II), (II- A), or (II-B), R6is selected from: hydrogen; Ci alkyl substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle; and C4-6 alkyl. In some embodiments, R6is selected from: hydrogen.

[0102] In some embodiments, for a compound or salt of Formula (I), (I-A), (I-B), (I-C), (II), (II- A), or (II-B), R5together with R6form a 3- to 12- membered heterocycle or C3-12 carbocycle, wherein the 3- to 12- membered heterocycle or C3-12 carbocycle is optionally substituted with one or more substituents independently selected from R9c. In some embodiments, R5together with R6form a C4-6 carbocycle. In some embodiments, R5together with R6form a 4- to 6- membered heterocycle. In some embodiments, R5together with R6form a C5 carbocycle. In some embodiments, R5together with R6form a 5- membered heterocycle.

[0103] In some embodiments, for a compound or salt of Formula (I), (I-A), (I-B), (I-C), (II), (II- A), or (II-B), , e.g., for a compound or salt of Formula (I) or (II), R8is selected from: hydrogen; andC1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -NO2, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle are optionally substituted with one or more substituents independently selected from halogen, -OR10f, - SR10f, -N(R10f)2, -NO2, and -CN.

[0104] In some embodiments, for a compound or salt of Formula (I), (I-A), (I-B), (I-C), (II), (II- A), or (II-B), e.g., for a compound or salt of Formula (I) or (II), R8is selected from hydrogen; and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, - OR10f, -SR10f, -N(R10f)2, -NO2, and -CN. In some embodiments, R8is selected from hydrogen and Ci. 6 alkyl optionally substituted with one or more substituents independently selected from halogen, CN, C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R8is selected from hydrogen and Ci-6 alkyl optionally substituted with one or more substituents independently selectedfrom halogen and CN. In some embodiments, R8is selected from hydrogen and Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen. In some embodiments, R8is selected from hydrogen, Ci-6 alkyl, and Ci- haloalkyl. In some embodiments, R8is selected from hydrogen and Ci-6 alkyl. In some embodiments, R8is selected from hydrogen; and Ci-4 alkyl optionally substituted with one or more substituents independently selected from halogen, - OR10f, -SR10f, -N(R10f)2, -NO2, and -CN. In some embodiments, R8is selected from hydrogen and Ci. 4 alkyl optionally substituted with one or more substituents independently selected from halogen, CN, C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R8is selected from hydrogen and Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen and CN. In some embodiments, R8is selected from hydrogen and C1.4 alkyl optionally substituted with one or more substituents independently selected from halogen. In some embodiments, R8is selected from hydrogen, C1-4 alkyl, and Ci- haloalkyl. In some embodiments, R8is selected from hydrogen and C1.4 alkyl. In some embodiments, R8is selected from hydrogen; and Ci alkyl optionally substituted with one or more substituents independently selected from halogen, - OR10f, -SR10f, -N(R10f)2, -NO2, and -CN. In some embodiments, R8is selected from hydrogen and Ci alkyl optionally substituted with one or more substituents independently selected from halogen, CN, C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R8is selected from hydrogen and Ci alkyl optionally substituted with one or more substituents independently selected from halogen and CN. In some embodiments, R8is selected from hydrogen and Ci alkyl optionally substituted with one or more substituents independently selected from halogen. In some embodiments, R8is selected from hydrogen, Ci alkyl, and Ci- haloalkyl. In some embodiments, R8is selected from hydrogen and Ci alkyl. In some embodiments, R8is selected from -CH3. In some embodiments, R8is selected from hydrogen. In some embodiments, when Ring A is a 5 -membered heterocycle, then: R8is selected from: hydrogen; and C1-4 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -NO2, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10- membered heterocycle are optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -NO2, and -CN.

[0105] In some embodiments, for a compound or salt of Formula (I), (I- A), (I-B), (I-C), (II), (II- A), or (II-B), e.g., for a compound or salt of Formula (I) or Formula (II), each R9a, R9h, and R9cis independently selected from: halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g- N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, - S(O)R10g, -S(O)2R10g, -NO2, =0, =S, =N(R10g), and -CN; andCi-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, - N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g-N(R10g)C(O)N(R10g)2, - OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =0, =S, =N(R10g), and -CN.

[0106] In some embodiments, each R9a, R9b, and R9care independently selected from: halogen, - OR10g, -SR10g, -N(R10g)2, -C(O)R10§, -C(O)N(R10g)2, -N(R10g)C(O)R10g-C(O)OR10g, -OC(O)R10g, - NO2, =0, and -CN; C1-3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, - N(R10g)C(O)R10g-C(O)OR10g, -OC(O)R10g, -NO2, =0, and -CN; and C3-10 carbocycle and 3- to 10- membered heterocycle. In some embodiments, each R9a, R9b, and R9care independently selected from: each R9a, R9b, and R9care independently selected from: halogen, -OR10g, -SR10g, - N(R10g)2, -C(O)R10g, -NO2, =0, and -CN; and C1-3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -NO2, =0, and -CN. In some embodiments, each R9a, R9b, and R9care independently selected from: F, Cl, Br, - OR10g, -N(R10g)2, -NO2, =0, and -CN; and C1-3 alkyl optionally substituted with one or more substituents independently selected from F, Cl, Br, -OR10g, -N(R10g)2, -NO2, =0, and -CN. In some embodiments, each R9a, R9b, and R9care independently selected from: halogen, -OR10g, -CN, C1.3 alkyl, and C1-3 haloalkyl. In some embodiments, each R9a, R9b, and R9care independently selected from: halogen, -OH, -CN, C1-3 alkyl, and C1.3 haloalkyl. In some embodiments, each R9a, R9b, and R9Care independently selected from: F, Cl, and -CN; and C1.3 alkyl optionally substituted with one or more substituents independently selected from F, Cl, and -CN. In some embodiments, each R9a, R9b, and R9Care independently selected from: F, Cl, -CN, and C1.3 alkyl. In some embodiments, each R9a, R9b, and R9care independently selected from: F, Cl, -CN; and methyl. In some embodiments, each R9a, R9b, and R9care independently selected from: F and -CN. In some embodiments, each R9a, R9b, and R9Care F. In some embodiments, each R9a, R9b, and R9care -CN.

[0107] In some embodiments, for a compound or salt of Formula (I), (I- A), (I-B), (I-C), (II), (II- A), or (II-B), e.g., for a compound or salt of Formula (I) or Formula (II), each R9ais independently selected from: halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g- N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, - S(O)R10g, -S(O)2R10g, -NO2, =0, =S, =N(R10g), and -CN; andC1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -

[0108] In some embodiments, each R9ais independently selected from: halogen, -OR10g, -SR10g, - N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g-C(O)OR10g, -OC(O)R10g, -NO2, =0, and - CN; C1.3 alkyl and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, - N(R10g)C(O)R10g-C(O)OR10g, -OC(O)R10g, -NO2, =0, and -CN; and C3-10 carbocycle and 3- to 10- membered heterocycle. In some embodiments, each R9ais independently selected from: each R9ais independently selected from: halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -NO2, =0, and -CN; and Ci-3 alkyl optionally substituted with one or more substituents independently selected from halogen, - OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -NO2, =0, and -CN. In some embodiments, each R9ais independently selected from: F, Cl, Br, -OR10g, -N(R10g)2, -NO2, =0, and -CN; and C1.3 alkyl optionally substituted with one or more substituents independently selected from F, Cl, Br, -OR10g, - N(R10g)2, -NO2, =0, and -CN. In some embodiments, each R9ais independently selected from: halogen, -OR10g, -CN, C1.3 alkyl, and C1.3 haloalkyl. In some embodiments, each R9ais independently selected from: halogen, —OH, -CN, C1-3 alkyl, and C 1-3 haloalkyl. In some embodiments, each R9ais independently selected from: F, Cl, and -CN; and C1-3 alkyl optionally substituted with one or more substituents independently selected from F, Cl, and -CN. In some embodiments, each R9ais independently selected from: F, Cl, -CN, and C1.3 alkyl. In some embodiments, each R9ais independently selected from: F, Cl, -CN; and methyl. In some embodiments, each R9ais independently selected from: F and -CN. In some embodiments, each R9ais independently selected from: F. In some embodiments, each R9ais independently selected from: -CN.

[0109] In some embodiments, for a compound or salt of Formula (I), (I- A), (I-B), (I-C), (II), (II- A), or (II-B), e.g., for a compound or salt of Formula (I) or Formula (II), each R9bis independently selected from: halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g- N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, - S(O)R10g, -S(O)2R10g, -NO2, =0, =S, =N(R10g), and -CN; andC1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, - N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g-N(R10g)C(O)N(R10g)2, - OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -NO2, =0, =S, =N(R10g), and -CN.

[0110] In some embodiments, each R9bis independently selected from: halogen, -OR10g, -SR10g, - N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g-C(O)OR10g, -OC(O)R10g, -NO2, =0, and - CN; Ci-3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g-C(O)OR10g, - OC(O)R10g, -NO2, =0, and -CN; and C3-io carbocycle and 3- to 10-membered heterocycle. In some embodiments, each R9bis independently selected from: each R9bis independently selected from: halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -NO2, =0, and -CN; and Ci-3alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, - N(R10g)2, -C(O)R10g, -NO2, =0, and -CN. In some embodiments, each R9bis independently selected from: F, Cl, Br, -OR10g, -N(R10g)2, -NO2, =0, and -CN; and C1-3 alkyl optionally substituted with one or more substituents independently selected from F, Cl, Br, -OR10g, -N(R10g)2, -N02, =0, and -CN. In some embodiments, each R9bis independently selected from: halogen, -OR10g, -CN, C1-3 alkyl, and C1-3 haloalkyl. In some embodiments, each R9bis independently selected from: halogen, —OH, -CN, C1-3 alkyl, and C1-3 haloalkyl. In some embodiments, each R9bis independently selected from: F, Cl, and -CN; and C1-3 alkyl optionally substituted with one or more substituents independently selected from F, Cl, and -CN. In some embodiments, each R9bis independently selected from: F, Cl, -CN, and C1-3 alkyl. In some embodiments, each R9bis independently selected from: F, Cl, -CN; and methyl. In some embodiments, each R9bis independently selected from: F and -CN. In some embodiments, each R9bis F. In some embodiments, each R9bis -CN.[OlH] In some embodiments, for a compound or salt of Formula (I), (I- A), (I-B), (I-C), (II), (II- A), or (II-B), e.g., for a compound or salt of Formula (I) or Formula (II), each R9cis independently selected from: halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g- N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, - S(O)R10g, -S(O)2R10g, -N02, =0, =S, =N(R10g), and -CN; andCi-3alkyl, C2.3alkenyl, and C2.3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, - N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g-N(R10g)C(O)N(R10g)2, - OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, -N02, =0, =S, =N(R10g), and -CN.

[0112] In some embodiments, for a compound or salt of Formula (I) or Formula (II), each R9cis independently selected from: halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, - N(R10g)C(O)R10g-C(O)OR10g, -OC(O)R10g, -N02, =0, and -CN; C1.3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g-C(O)OR10g, -OC(O)R10g, -N02, =0, and - CN; and C3 -10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, each R9cis independently selected from: each R9cis independently selected from: halogen, -OR10g, -SR10g, - N(R10g)2, -C(O)R10g, -NO2, =0, and -CN; and C1-3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -NO2, =0, and -CN. In some embodiments, each R9cis independently selected from: F, Cl, Br, -OR10g, - N(R10g)2, -NO2, =0, and -CN; and C1-3 alkyl optionally substituted with one or more substituents independently selected from F, Cl, Br, -OR10g, -N(R10g)2, -NO2, =0, and -CN. In some embodiments, each R9Cis independently selected from: halogen, -OR10g, -CN, C1-3 alkyl, and C1-3 haloalkyl. In some embodiments, each R9cis independently selected from: halogen, -OH, -CN, C1-3 alkyl, and Ci- 3 haloalkyl. In some embodiments, each R9cis independently selected from: F, Cl, and -CN; and C1-3 alkyl optionally substituted with one or more substituents independently selected from F, Cl, and - CN. In some embodiments, each R9cis independently selected from: F, Cl, -CN, and C1.3 alkyl. In some embodiments, each R9cis independently selected from: F, Cl, -CN; and methyl. In some embodiments, each R9cis independently selected from: F and -CN. In some embodiments, each R9cis independently selected from: F. In some embodiments, each R9cis independently selected from: - CN.

[0113] In some embodiments, for a compound or salt of Formula (I), (I- A), (I-B), (I-C), (II), (II- A), or (II-B), e.g., for a compound or salt of Formula (I) or Formula (II), each R10a, R10b, R10c, R10d, R10f, and R10gis independently selected from: hydrogen;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(Ci-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, - SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl.

[0114] In some embodiments, for a compound or salt of Formula (I), (I- A), (I-B), (I-C), (II), (II- A), or (II-B), e.g., for a compound or salt of Formula (I) or (II), each R10a, R10b, R10c, R10d, R10f, and R10gis independently selected from hydrogen, C1-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C1-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle are eachoptionally substituted with one or more substituents independently selected from halogen, -CN, -OH, and -NH2. In some embodiments, each R10a, R10b, R10c, R10d, R10f, and R10gis independently selected from hydrogen; and Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, and -NH2. In some embodiments, each R10a, R10b, R10c, R10d, R10f, and R10gis independently selected from hydrogen, C1-3 alkyl, and C1-3 haloalkyl.

[0115] In some embodiments, for a compound or salt of Formula (I), (I- A), (I-B), (I-C), (II), (II- A), or (II-B), e.g., for a compound or salt of Formula (I) or (II), each R10ais independently selected from: hydrogen; and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(Ci-6 alkyl)2, - NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl. In some embodiments, each R10ais independently selected from hydrogen; and Ci-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2,and =0; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, - Ci-6 alkyl, and Ci-6 haloalkyl. In some embodiments, R10ais independently selected from hydrogen; and Ci-6 alkyl optionally substituted with one or more substituents independently selected from fluorine and chlorine; and C3-10 carbocycle, and 3- to 10- membered heterocycle. In some embodiments, R10ais independently selected from hydrogen; and Ci- 6 alkyl optionally substituted with fluorine; and C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R10ais hydrogen. In some embodiments, R10ais methyl.

[0116] In some embodiments, for a compound or salt of Formula (I), (I- A), (I-B), (I-C), (II), (II- A), or (II-B), e.g., for a compound or salt of Formula (I) or (II), each R10bis independently selected from: hydrogen; and Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, - NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), Ci-6 alkyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C 1-6 haloalkyl. In some embodiments, each R10bis independently selected from hydrogen; and Ci-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2,and =0; and C3-10 carbocycle, and 3- to 10-membered heterocycle, eachof which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, - Ci-6 alkyl, and Ci-e haloalkyl. In some embodiments, R10bis independently selected from hydrogen; and Ci-6 alkyl optionally substituted with one or more substituents independently selected from fluorine and chlorine; and C3-10 carbocycle, and 3- to 10- membered heterocycle. In some embodiments, R10bis independently selected from hydrogen; and Ci- 6 alkyl optionally substituted with fluorine, and C3-10 carbocycle, and 3- to 10-membered heterocycle In some embodiments, R10bis hydrogen. In some embodiments, R10bis methyl.

[0117] In some embodiments, for a compound or salt of Formula (I), (I- A), (I-B), (I-C), (II), (II- A), or (II-B), e g., for a compound or salt of Formula (I) or (II), each R10cis independently selected from: hydrogen; and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, - NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, O, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(Ci-6 alkyl), C1-6 alkyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-e haloalkyl. In some embodiments, each R10cis independently selected from hydrogen; and Ci-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2,and =0; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, - Ci-6 alkyl, and Ci-e haloalkyl. In some embodiments, R10cis independently selected from hydrogen; and Ci-6 alkyl optionally substituted with one or more substituents independently selected from fluorine and chlorine; and C3-10 carbocycle, and 3- to 10- membered heterocycle. In some embodiments, R10cis independently selected from hydrogen; and Ci- 6 alkyl optionally substituted with fluorine; and C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R10cis hydrogen. In some embodiments, R10cis methyl.

[0118] In some embodiments, for a compound or salt of Formula (I), (I- A), (I-B), (I-C), (II), (II- A), or (II-B), e.g., for a compound or salt of Formula (I) or (II), each R10dis independently selected from: hydrogen; and Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, - NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(Ci-6 alkyl), Ci-6 alkyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-e haloalkyl. In some embodiments, each R10dis independently selected from hydrogen; andCi-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2,and =0; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, - Ci-6 alkyl, and Ci-g haloalkyl. In some embodiments, R10dis independently selected from hydrogen; and C1-6 alkyl optionally substituted with one or more substituents independently selected from fluorine and chlorine; and C3-10 carbocycle, and 3- to 10- membered heterocycle. In some embodiments, R10dis independently selected from hydrogen; and Ci- 6 alkyl optionally substituted with fluorine; and C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R10dis hydrogen. In some embodiments, R10dis methyl.

[0119] In some embodiments, for a compound or salt of Formula (I), (I- A), (I-B), (I-C), (II), (II- A), or (II-B), e.g., for a compound or salt of Formula (I) or (II), each R10fis independently selected from: hydrogen; and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, - NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(Ci-6 alkyl), C1-6 alkyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-e haloalkyl. In some embodiments, each R10fis independently selected from hydrogen; and Ci- 6 alkyl, optionally substituted with one or more substituents independently selected from halogen, - CN, -OH, -SH, -NO2, - H2,and =0; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, - Ci-6 alkyl, and Ci-g haloalkyl. In some embodiments, R10fis independently selected from hydrogen; and Ci-6 alkyl optionally substituted with one or more substituents independently selected from fluorine and chlorine; and C3-10 carbocycle, and 3- to 10- membered heterocycle. In some embodiments, R10fis independently selected from hydrogen; and Ci- 6 alkyl optionally substituted with fluorine; and C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R10fis hydrogen. In some embodiments, R10fis methyl.

[0120] In some embodiments, for a compound or salt of Formula (I), (I- A), (I-B), (I-C), (II), (II- A), or (II-B), e.g., for a compound or salt of Formula (I) or (II), each R10gis independently selected from: hydrogen; and Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, - NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C1-6 alkyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-e haloalkyl. In some embodiments, each R10gis independently selected from hydrogen; and Ci-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -N02, -NH2,and =0; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -N02, -NH2, =0, - Ci-6 alkyl, and Ci-e haloalkyl. In some embodiments, R10gis independently selected from hydrogen; and Ci-6 alkyl optionally substituted with one or more substituents independently selected from fluorine and chlorine; and C3-10 carbocycle, and 3- to 10- membered heterocycle. In some embodiments, R10gis independently selected from hydrogen; and Ci- 6 alkyl optionally substituted with fluorine; and C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R10gis hydrogen. In some embodiments, R10gis methyl.

[0121] In some embodiments, for a compound or salt of Formula (I), (I- A), (I-B), (I-C), (II), (II- A), or (II-B), e.g., for a compound or salt of Formula (I) or (II), the compound or salt is selected from: a compound of Table 1, or a salt thereof.

[0122] In another aspect, disclosed herein is a compound represented by Formula (III-C):or a salt thereof, wherein:X11, X12, X13, and X14are each independently selected from C(R" ), and N; each R11is independently selected from: hydrogen; halogen, -NO2, -CN, -OR20a, -SR20a, -N(R20a)2, -C(O)R20a, -C(O)N(R20a)2, - N(R20a)C(O)R20a-N(R20a)C(O)N(R20a)2, -OC(O)N(R20a)2, -N(R20a)C(O)OR20a, -C(O)OR20a, -OC(O)R20a, -S(O)R20a, and -S(O)2R20a;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20a, -SR20a, - N(R20a)2, -C(O)R20a, -C(O)N(R20a)2, -N(R20a)C(O)R20a, -C(O)OR20a, -OC(O)R20a, - N(R20a)C(O)N(R20a)2, -OC(O)N(R20a)2, -N(R20a)C(O)OR20a, -S(O)R20a, -S(O)2R20a, -NO2, =0, =S, =N(R20a), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19a; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20a, - SR20a, -N(R20a)2, -C(O)R20a, -C(O)N(R20a)2, -N(R20a)C(O)R20a, -N(R20a)C(O)N(R20a)2, - OC(O)N(R20a)2, -N(R20a)C(O)OR20a, -C(O)OR20a, -OC(O)R20a, -S(O)R20a, -S(O)2R20a, - NO2, =0, =S, =N(R20a), -CN, Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein Ci-6 alkyl, C2.6 alkenyl, and C2.6 alkynyl are each optionally substituted with one or more R19a;R12is selected from:Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20b, -SR20b, - N(R20b)2, -C(O)R20b, -C(O)N(R20b)2, -N(R20b)C(O)R20b-OC(O)R20b, - N(R20b)C(O)N(R20b)2, -OC(O)N(R20b)2, -N(R20b)C(O)OR20b, -S(O)R20b, -S(O)2R20b, -N02, =S, =N(R20b), -CN, C3-io carbocycle and 3- to 10-membered heterocycle, wherein the C3. io carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19b; andC3-io carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20b, - SR20b, -N(R20h)2, -C(O)R20b, -C(O)N(R20b)2, -N(R20b)C(O)R20b-N(R20b)C(O)N(R20b)2, - OC(O)N(R20b)2, -N(R20b)C(O)OR20b, -C(O)OR20h, -OC(O)R20b, -S(O)R20b, -S(O)2R20b, - NO2, =0, =S, =N(R20h), -CN, Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R19b; and R13and R14are each independently selected from: hydrogen, halogen, -OR2011, -SR20c, -N(R20c)2, -NO2, and -CN; andCi-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR20c, -SR20c, -N(R20c)2, -NO2, and -CN;R15is independently selected from: hydrogen, halogen, -OR20d, -SR20d, -N(R20d)2, -NO2, and -CN;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20d, -SR20d, - N(R20d)2, -C(O)R20d, -C(O)N(R20d)2, -N(R20d)C(O)R20d-C(O)OR20d, -OC(O)R20d, - N(R20d)C(O)N(R20d)2, -OC(O)N(R20d)2, -N(R20d)C(O)OR20d, -S(O)R20d, -S(O)2R20d, -NO2, =0, =S, =N(R20d), and -CN; orR15together with R16form a 3 - to 10- membered heterocycle or C3-io carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more R19c;R16is independently selected from:Ci-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19c; andC4-6 alkyl, C4-6 alkenyl, and C4-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10- membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19c; orR15together with R16form a 3 - to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more R19c;R17is selected from: hydrogen and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR20e, -SR20e, -N(R20e)2, -NO2, and -CN;R18is selected from: hydrogen; andCi-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR20f, -SR20f, -N(R20f)2, -NO2, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle are optionally substituted with one or more substituents independently selected from halogen, -OR20f, -SR20f, -N(R20f)2, -NO2, and -CN; each R19a, R19b, R19c, are independently selected from: halogen, -OR20g, -SR20g, -N(R20g)2, -C(O)R20g, -C(O)N(R20g)2, -N(R20g)C(O)R20g- N(R20g)C(O)N(R20g)2, -OC(O)N(R20g)2, -N(R20g)C(O)OR20g, -C(O)OR20g, -OC(O)R20g, - S(O)R20g, -S(O)2R20g, -NO2, =0, =S, =N(R20g), and -CN; andC1.3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20g, -SR20g, - N(R20g)2, -C(O)R20g, -C(O)N(R20g)2, -N(R20g)C(O)R20g-N(R20g)C(O)N(R20g)2, - OC(O)N(R20g)2, -N(R20g)C(O)OR20g, -C(O)OR20g, -OC(O)R20g, -S(O)R20g, -S(O)2R20g, - NO2, =0, =S, =N(R20g), and -CN; each R20a, R20b, R20c, R20dR20e, R20f, and R20gis independently selected from: hydrogen;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - NO2, -NH2, =0, =S, -O-C1.6 alkyl, -S-Ci-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-g haloalkyl; andR20his independently selected from: hydrogen;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - NO2, -NH2, -O, =S, -O-C1-6 alkyl, -S-Ci-6 alkyl, -N(CI-6alkyl)2, -NH(Ci-e alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-Ci-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-s haloalkyl.

[0123] In another aspect, disclosed herein is a compound represented by Formula (III):or a salt thereof, wherein:X11, X12, X13, and X14are each independently selected from C(Rn), and N; each R11is independently selected from: hydrogen; halogen, -N02, -CN, -OR20a, -SR20a, -N(R20a)2, -C(O)R20a, -C(O)N(R20a)2, -N(R20a)C(O)R20a, -N(R20a)C(O)N(R20a)2, -OC(O)N(R20a)2, -N(R20a)C(O)OR20a, -C(O)OR20a, -OC(O)R20a, -S(O)R20a, and -S(O)2R20a;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20a, -SR20a, - N(R20a)2, -C(O)R20a, -C(O)N(R20a)2, -N(R20a)C(O)R20a, -C(O)OR20a, -OC(O)R20a, - N(R20a)C(O)N(R20a)2, -OC(O)N(R20a)2, -N(R20a)C(O)OR20a, -S(O)R20a, -S(O)2R20a, -NO2, =0, =S, =N(R20a), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19a; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20a, - SR20a, -N(R20a)2, -C(O)R20a, -C(O)N(R20a)2, -N(R20a)C(O)R20a, -N(R20a)C(O)N(R20a)2, - OC(O)N(R20a)2, -N(R20a)C(O)OR20a, -C(O)OR20a, -OC(O)R20a, -S(O)R20a, -S(O)2R20a, - NO2, =0, =S, =N(R20a), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R19a;R12is selected from:Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20b, -SR20b, - N(R20b)2, -C(O)R20b, -C(O)N(R20b)2, -N(R20b)C(O)R20b. -C(O)OR20b, -OC(O)R20b, - N(R20b)C(O)N(R20b)2, -OC(O)N(R20b)2, -N(R20b)C(O)OR20b, -S(O)R20b, -S(O)2R20b, -NO2, =0, =S, =N(R20b), -CN, C3-io carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20b, - SR20b, -N(R20h)2, -C(O)R20b, -C(O)N(R20b)2, -N(R20b)C(O)R20b-N(R20b)C(O)N(R20b)2, - OC(O)N(R20b)2, -N(R20b)C(O)OR20b, -C(O)OR20h, -OC(O)R20b, -S(O)R20b, -S(O)2R20b, - NO2, =0, =S, =N(R20h), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R19b; andR13and R14are each independently selected from: hydrogen, halogen, -OR2011, -SR20c, -N(R20c)2, -NO2, and -CN; andCi-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR20c, -SR20c, -N(R20c)2, -NO2, and -CN;R15is independently selected from: hydrogen, halogen, -OR20d, -SR20d, -N(R20d)2, -NO2, and -CN;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20d, -SR20d, - N(R20d)2, -C(O)R20d, -C(O)N(R20d)2, -N(R20d)C(O)R20d-C(O)OR20d, -OC(O)R20d, - N(R20d)C(O)N(R20d)2, -OC(O)N(R20d)2, -N(R20d)C(O)OR20d, -S(O)R20d, -S(O)2R20d, -NO2, =0, =S, =N(R20d), and -CN; andR16is independently selected from:Ci-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19c; andC4-6 alkyl, C4-6 alkenyl, and C4-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10- membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19c; orR15together with R16form a 3 - to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more R19c;R17is selected from: hydrogen and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR20e, -SR20e, -N(R20e)2, -NO2, and -CN;R18is selected from: hydrogen; andCi-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR20f, -SR20f, -N(R20f)2, -NO2, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle are optionally substituted with one or more substituents independently selected from halogen, -OR20f, -SR20f, -N(R20f)2, -NO2, and -CN; each R19a, R19b, R19c, are independently selected from: halogen, -OR20g, -SR20g, -N(R20g)2, -C(O)R20g, -C(O)N(R20g)2, -N(R20g)C(O)R20g- N(R20g)C(O)N(R20g)2, -OC(O)N(R20g)2, -N(R20g)C(O)OR20g, -C(O)OR20g, -OC(O)R20g, - S(O)R20g, -S(O)2R20g, -NO2, =0, =S, =N(R20g), and -CN; andCi-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20g, -SR20g, - N(R20g)2, -C(O)R20g, -C(O)N(R20g)2, -N(R20g)C(O)R20g-N(R20g)C(O)N(R20g)2, -OC(O)N(R20g)2, -N(R20g)C(O)OR20g, -C(O)OR20g, -OC(O)R20g, -S(O)R20g, -S(O)2R20g- N02, =0, =S, =N(R20g), and -CN; each R20a, R20b, R20c, R20dR20e, R20f, and R20gis independently selected from: hydrogen;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, 0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-e haloalkyl; andR20his independently selected from:Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - NO2, -NH2, 0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-Ci-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-s haloalkyl.

[0124] In another aspect, disclosed herein is a compound of Formula (III) is represented by Formula (III-A):or a salt thereof, wherein:X11, X12, X13, and X14are each independently selected from C(Rn), and N; each R11is independently selected from:hydrogen; halogen, -OR20a, -SR20a, -N(R20a)2, -C(O)R20a, -C(O)N(R20a)2, -N02, and -CN;Ci-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR20a, -SR20a, -N(R20a)2, -C(O)R20a, -NO2, -CN, C3-10 carbocycle and 3- to 10- membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9a, andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20a, - SR20a, -N(R20a)2, -C(O)R20a, -C(O)N(R20a)2, -NO2, -CN; and Ci-6alkyl optionally substituted with one or more R19a;R12is selected from:C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR20b, -SR20h, -N(R20b)2, -C(O)R20b, -C(O)N(R20b)2, -NO2, =0, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10- membered heterocycle are each optionally substituted with one or more R19b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20b, - SR20b, -N(R20h)2, -NO2, =0, -CN, C1-6 alkyl, wherein Ci-6 alkyl is optionally substituted with one or more R19b;R13and R14are each independently selected from: hydrogen, halogen, -OR2011, -N(R20c)2, and -CN; andCi-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR20c, -N(R20c)2, and -CN;R15is independently selected from hydrogen, halogen, -OR20d, -SR20d, -N(R20d)2, -NO2, and -CN; and Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR20d, -SR20d, -N(R20d)2, -N02, =0, and -CN;R16is selected from:C1-3 alkyl substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19c; andC4-6 alkyl optionally substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19c;R17is selected from: hydrogen and Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR20e, -N(R20e)2, and -CN;R18is selected from: hydrogen; and Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR20f, -N(R20f)2, and -CN; each R19a, R19b, R19c, are independently selected from halogen, -OR20g, -N(R20g)2, C1-3 alkyl, and C1-3 haloalkyl; each R20a, R20b, R20c, R20dR20e, R20f, and R20gis independently selected from: hydrogen, Ci-6alkyl, and Ci-6 haloalkyl; andR20his independently selected from Ci-6 alkyl and C 1-6 haloalkyl.

[0125] In some embodiments, for a salt or compound of Formula (III), wherein the compound is not

[0126] In some embodiments, for a compound or salt of Formula (III), (III- A), (III-C), e.g., for a compound or salt of Formula (III), at least one of X11, X12, X13, or X14is N. In some embodiments, at least two of X11, X12, X13, or X14is N. In some embodiments, at least one of X11, X12, X13, or X14is N, and no more than two of X11, X12, X13, and X14are N. In some embodiments, X11, X12, X13, and X14are each C(Rn). In some embodiments, one of X11, X12, X13, or X14is N. In some embodiments, two of X11, X12, X13, and X14are N In some embodiments, three of X11, X12, X13, and X14are N. In some embodiments, at least one of X11, X12, X13, or X14is C(Rn). In some embodiments, at least two of X11, X12, X13, and X14are C(Rn). In some embodiments, at least three of X11, X12, X13, and X14are C(Rn). In some embodiments, three of X11, X12, X13, and X14are N. In some embodiments, one of X11, X12, X13, or X14is C(Rn). In some embodiments, two of X11, X12, X13, and X14are C(Rn). In some embodiments, three of X11, X12, X13, and X14are CfR11). In some embodiments, four of X11, X12, X13, and X14are C(Rn). In some embodiments, X11is N. In some embodiments, X12is N. In some embodiments, X13is N. In some embodiments, X14is N. In some embodiments, X11is C(Rn). In some embodiments, X12is C(Rn). In some embodiments, X13is C(Rn). In some embodiments, X14is C(Rn). In some embodiments, X11is C(H). In some embodiments, X12is C(H). In some embodiments, X13is C(H). In some embodiments, X14is C(H). In some embodiments, X11is N, and X12, X13, and X14are C(Rn). In some embodiments, X12is N, and X11, X13, and X14are C(Rn). In some embodiments, X13is N, and X11, X12, and X14are C(Rn). In some embodiments, X14is N, and X11, X12, and X13are C(Rn). In some embodiments, X11is N, and X12, X13, and X14are C(H). In some embodiments, X12is N, and X11, X13, and X14are C(H). In some embodiments, X13is N, and X11, X12, and X14are C(H). In some embodiments, X14is N, and X11, X12, and X13are C(H).

[0127] In certain embodiments, for a compound or salt of Formula (III), (III-A), (III-C), e.g., for a compound or salt of Formula (III), each R11is independently selected from: hydrogen; halogen, -NO2, -CN, -OR20a, -SR20a, -N(R20a)2, -C(O)R20a, -C(O)N(R20a)2, - N(R20a)C(O)R20a-N(R20a)C(O)N(R20a)2, -OC(O)N(R20a)2, -N(R20a)C(O)OR20a, -C(O)OR20a, - OC(O)R20a, -S(O)R20a, and -S(O)2R20a;Ci-6 alkyl, C2-6 alkenyl, and C2.6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20a, -SR20a, - N(R20a)2, -C(O)R20a, -C(O)N(R20a)2, -N(R20a)C(O)R20a, -C(O)OR20a, -OC(O)R20a, - N(R20a)C(O)N(R20a)2, -OC(O)N(R20a)2, -N(R20a)C(O)OR20a, -S(O)R20a, -S(O)2R20a, -NO2, =0, =S, =N(R20a), -CN, C3-io carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19a; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20a, - SR20a, -N(R20a)2, -C(O)R20a, -C(O)N(R20a)2, -N(R20a)C(O)R20a-N(R20a)C(O)N(R20a)2, - OC(O)N(R20a)2, -N(R20a)C(O)OR20a, -C(O)OR20a, -OC(O)R20a, -S(O)R20a, -S(O)2R20a, -NO2, =0, =S, =N(R20a), -CN, Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein Ci-6 alkyl, C2-6 alkenyl, and C2.6 alkynyl are each optionally substituted with one or more R19a

[0128] In some embodiments, for a compound or salt of Formula (III), (III- A), (III-C), e.g., for a compound or salt of Formula (III), each R11is independently selected from: hydrogen; halogen, -OR20a, -SR20a, -N(R20a)2, -C(O)R20a, -C(O)N(R20a)2, -NO2, and - CN;Ci-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR20a, -SR20a, -N(R20a)2, -C(O)R20a, -NO2, -CN, C3-10 carbocycle and 3- to 10- membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19a; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20a, - SR20a, -N(R20a)2, -C(O)R20a, -C(O)N(R20a)2, -NO2, -CN; and Ci-6alkyl optionally substituted with one or more R19a.

[0129] In some embodiments, for a compound or salt of Formula (III), (III- A), (III-C), e.g., for a compound or salt of Formula (III), each R11is independently selected from: hydrogen; halogen, -OR20a, -SR20a, -N(R20a)2, -C(O)R20a, -C(O)N(R20a)2, -NO2, and - CN;Ci-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR20a, -SR20a, and -N(R20a)2; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20a, - SR20a, and -N(R20a)2.

[0130] In some embodiments, for a compound or salt of Formula (III), (III- A), (III-C), e.g., for a compound or salt of Formula (III), each R11is independently selected from: hydrogen, halogen, -OR20a, -SR20a, -N(R20a)2, -C(O)R20a, -C(O)N(R20a)2, -NO2, and - CN;Ci-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR20a, -N(R20a)2, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20a, - N(R20a)2, and -CN.

[0131] In some embodiments, for a compound or salt of Formula (III), (III- A), (III-C), e.g., for a compound or salt of Formula (III), each R11is independently selected from: hydrogen, halogen, - OR20a, -SR20a, -N(R20a)2, -C(O)R20a, -C(O)N(R20a)2, -NO2, and -CN; and Ci-6alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR20a, -SR20a, - N(R20a)2, -C(O)R20a, -C(O)N(R20a)2, -NO2, and -CN. In some embodiments, each R11is independently selected from: hydrogen, halogen, -OR20a, -SR20a, -N(R20a)2, -C(O)R20a, - C(O)N(R20a)2, -NO2, and -CN; and Ci-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR20a, -N(R20a)2, and -CN. In some embodiments, R11is independently selected from each R11is independently selected from: hydrogen, halogen, -OR20a, - SR20a, -N(R20a)2, -C(O)R20a, -C(O)N(R20a)2, -NO2, -CN, Ci-6alkyl, and Ci-6haloalkyl. In some embodiments, each R11is independently selected from hydrogen, halogen, -OR20a, -N(R20a)2, -CN, Ci-6 alkyl, and Ci-6 haloalkyl. In some embodiments, each R11is independently selected from hydrogen, F, -Cl, -OH, -NH2, -CN, -OMe, and -OCF3; and C1-3 alkyl optionally substituted with one or more substituents independently selected from -F and -Cl. In some embodiments, each R11is independently selected from hydrogen, -F, -Cl, -OH, -NH2, and CN; and C1-3 alkyl optionally substituted with one or more substituents independently selected from -F and -Cl. In some embodiments, each R11is independently selected from hydrogen, halogen, -CN, methyl, and -CF3. In some embodiments, each R11is independently selected from hydrogen, -F, -Cl, -CN, methyl, and - CF3.

[0132] In some embodiments, for a compound or salt of Formula (III), (III- A), (III-C), e.g., for a compound or salt of Formula (III), each R11is independently selected from: hydrogen, halogen, - OR20a, -SR20a, -N(R20a)2, -C(O)R20a, -C(O)N(R20a)2, -NO2, and -CN. In some embodiments, each R11is independently selected from hydrogen, halogen, -OR20a, -N(R20a)2, and -CN. In some embodiments, each R11is independently selected from hydrogen, F, -Cl, -OH, -NH2, -CN, -OMe, and -OCF3. In some embodiments, each R11is independently selected from hydrogen, -F, -Cl, -OH, - NH2, and CN. In some embodiments, each R11is independently selected from hydrogen, halogen, and -CN. In some embodiments, each R11is independently selected from hydrogen, -F, -Cl, and CN. In some embodiments, each R11is independently selected from hydrogen, -Cl, and -CN. In some embodiments, each R11is independently selected from hydrogen and -CN. In some embodiments, each R11is independently selected from hydrogen and halogen. In some embodiments, each R11is independently selected from hydrogen, -F, and -Cl. In some embodiments, each R11is independentlyselected from hydrogen and -F. In some embodiments, each R11is independently selected from hydrogen.

[0133] In some embodiments, for a compound or salt of Formula (III), (III- A), (III-C), e g., for a compound or salt of Formula (III), each R11is independently selected from hydrogen and Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR20a, - N(R20a)2, -NO2, and -CN. In some embodiments, each R11is independently selected from hydrogen and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR20a, -N(R20a)2, and -CN. In some embodiments, each R11is independently selected from hydrogen, Ci-6 alkyl, and Ci-6 haloalkyl. In some embodiments, each R11is independently selected from hydrogen, C1-3 alkyl, and C1-3 haloalkyl. In some embodiments, each R11is independently selected from hydrogen and C1.3 alkyl optionally substituted with -F and -Cl. In some embodiments, each R11is independently selected from hydrogen and methyl.

[0134] In some embodiments, for a compound or salt of Formula (III), (III- A), (III-C), e.g.,for a compound or salt of Formula (III), each R11is selected from hydrogen, C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20a, -N(R20a)2, -CN, Ci-6 alkyl, and Ci-6 haloalkyl. In some embodiments, each R11is selected from hydrogen, C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, Ci-6 alkyl, and Ci-6 haloalkyl. In some embodiments, each R11is selected from hydrogen, C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, and C1-3 alkyl optionally substituted with one or more substituents independently selected from -F and -Cl.

[0135] In some embodiments, for a compound or salt of Formula (III), (III- A), (III-C), e.g.,for a salt or compound of Formula (III), R12is selected from:Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20b, -SR20b, - N(R20b)2, -C(O)R20b, -C(O)N(R20b)2, -N(R20b)C(O)R20b-C(O)OR20b, -OC(O)R20b, -NO2, =0, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20b, - SR20b, -N(R20b)2, -C(O)R20b, -C(O)N(R20b)2, -N(R20b)C(O)R20b-C(O)OR20b, -OC(O)R20b, -N02, =0, -CN, Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R19b.

[0136] In some embodiments, for a compound or salt of Formula (III), (III- A), (III-C), e g., for a salt or compound of Formula (III), R12is selected fromC1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR20b, -SR20b, -N(R20b)2, -C(O)R20b, -N02, =0, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20b, - SR20b, -N(R20b)2, -NO2, =0, -CN, Ci-6 alkyl, wherein C1-6 alkyl is optionally substituted with one or more R19b.

[0137] In some embodiments, for a compound or salt of Formula (III), (III- A), (III-C), e.g.,for a salt or compound of Formula (III), wherein R12is selected from:C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR20b, -N(R20b)2, -CN, =0, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, -OH, -NH2, and - CN.

[0138] In some embodiments, for a compound or salt of Formula (III), (III- A), (III-C), e.g.,for a salt or compound of Formula (III), R12is C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR20b, -SR20b, -N(R20b)2, -C(O)R20b, -C(O)N(R20b)2, - N(R20b)C(O)R20b-C(O)OR20b, -OC(O)R20b, NO2, =0, =S, =N(R20b), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19b. In some embodiments, R12is C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR20b, -SR20b, - N(R20b)2, -C(O)R20b, -NO2, =0, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19b. In some embodiments, R12is C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR20b, -SR20b, -N(R20b)2, -NO2, =0, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19b. In some embodiments, R12is C1-6alkyl, optionally substituted with one or more substituents independently selected from halogen, - OR20b, -N(R20b)2, -NO2, =0, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19b. In some embodiments, R12is selected from C1-6 alkyl, optionally substituted with one or more substituents independently selected from -F, Cl, -OH, -NH2, -CN, and C3-10 carbocycle and 3- to 10- membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19b. In some embodiments, R12is C1-6 alkyl, optionally substituted with one or more substituents independently selected from OH, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19b. In some embodiments, R12is selected from C2 alkyl, optionally substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from -F, -Cl, - OH, -NH2, and -CN. In some embodiments, R12is selected from C2 alkyl, optionally substituted with one or more substituents independently selected from C3-6 carbocycle and 3- to 6-membered heterocycle, wherein the C3-6 carbocycle and 3- to 6-membered heterocycle are each optionally substituted with one or more substituents independently selected from -F, -Cl, -OH, -NH2, and -CN.

[0139] In some embodiments, for a compound or salt of Formula (III), (III- A), (III-C), e.g., for a salt or compound of Formula (III), R12is C1-6 alkyl, optionally substituted with one or more substituents independently selected from OH, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is independently selected from phenyl and pyridyl, and each phenyl and pyridyl is optionally substituted with one or more R19b. In some embodiments, R12is C2 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR20b, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3- 10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19b. In some embodiments, R12is C2 alkyl, optionally substituted with one or more substituents independently selected from OH, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19b. In some embodiments, R12is C2 alkyl, optionally substituted with one or more substituents independently selected from OH, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is independently selected from phenyl and pyridyl, and each phenyl and pyridyl is optionally substituted with one or more R19b.

[0140] In some embodiments, for a compound or salt of Formula (III), (III- A), (III-C), e.g., for a salt or compound of Formula (III), R12is selected from C2 alkyl, optionally substituted with one or moresubstituents independently selected from -OR20b, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is independently selected from phenyl and pyridyl, and each phenyl and pyridyl is optionally substituted with one or more substituents independently selected from -F, -Cl, -OH, -NH2, and -CN. In some embodiments, R12is selected from C2 alkyl, optionally substituted with one or more substituents independently selected from -OH, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle; and wherein each C3-10 carbocycle and 3- to 10- membered heterocycle is independently selected from phenyl and pyridyl, and each phenyl and pyridyl is optionally substituted with one or more substituents independently selected from -F, -Cl, - OH, -NH2, and -CN.

[0141] In some embodiments, for a compound or salt of Formula (III), (IILA), (IILC), e.g., for a salt or compound of Formula (III), R12is selected from

[0142] In some embodiments, for a compound or salt of Formula (III), (III- A), (III-C), e.g., for a compound or salt of Formula (III), R13and R14are each independently selected from hydrogen, halogen, -OR2011, -SR20c, -N(R20c)2, -NO2, and -CN; and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR2011, -SR20c, -N(R20c)2, -NO2, and -CN. In some embodiments, R13and R14are each independently selected from hydrogen, halogen, -OR20h, - N(R20C)2, -NO2, and -CN; and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR20h, -N(R20c)2, -NO2, and -CN. In some embodiments, R13and R14are each independently selected from: hydrogen, halogen, -NO2, -CN, C1-6 alkyl and C1-6 haloalkyl. In some embodiments, R13and R14are each independently selected from: hydrogen, halogen, Ci-6 alkyl and C1-6 haloalkyl. In some embodiments, R13and R14are each independently selected from: hydrogen, Ci-6 alkyl and Ci-6 haloalkyl. In some embodiments, R13and R14are each independently selected from hydrogen and Ci-6 alkyl. In some embodiments, R13and R14are each independently selected from: hydrogen and methyl. In some embodiments, R13and R14are each hydrogen. In some embodiments, R13is hydrogen. In some embodiments, R14is hydrogen. In some embodiments, R13is -OH, and R14is -H.

[0143] In some embodiments, for a compound or salt of Formula (III), (III- A), (III-C), e.g., for a compound or salt of Formula (III), R12and R13form a ring selected from any Ring A of any of Formulas (I), (LA), (LB), (LC), (II), (ILA), and (ILB).

[0144] In some embodiments, for a compound or salt of Formula (III), (IILA), (IILC), e.g., for a compound or salt of Formula (III), R15is selected from hydrogen, halogen, -OR20d, -SR20d, -N(R20d)2, -NO2, and -CN; and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR20d, -SR20d, -N(R20d)2, -NO2, =0, and -CN; and R16is selected from:Ci-3 alkyl substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19c; and C4-6 alkyl optionally substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19c.

[0145] In some embodiments, for a compound or salt of Formula (III), (III- A), (III-C), e.g., for a compound or salt of Formula (III), R15is hydrogen; and R16is selected from: C1-3 alkyl substituted with one or more substituents independently selected from C3-6 carbocycle and 3- to 6- membered heterocycle, wherein the C3-6 carbocycle and 3- to 6-membered heterocycle are each optionally substituted with halogen, -OR20d, -N(R20d)2, -CN, C1-3 alkyl, and C1-3 haloalkyl; and C4-6 alkyl optionally substituted with one or more substituents independently selected from C3-6 carbocycle and 3- to 6-membered heterocycle, wherein the C3-6 carbocycle and 3- to 6-membered heterocycle are each optionally substituted with halogen, -OR20d, -N(R20d)2, -CN, C1-3 alkyl, and C1-3 haloalkyl. In some embodiments, R15is hydrogen; and R16is selected from: C1-3 alkyl substituted with one or more substituents independently selected from C3-6 carbocycle and 3- to 6- membered heterocycle, wherein the C3-6 carbocycle and 3- to 6-membered heterocycle are each optionally substituted with - F, -Cl, -OH, -NH2, -CN; and C1-3 alkyl optionally substituted with one or more substituents independently selected from -F and -Cl; and C4-6 alkyl optionally substituted with one or more substituents independently selected from C3-6 carbocycle and 3- to 6-membered heterocycle, wherein the C3-6 carbocycle and 3- to 6-membered heterocycle are each optionally substituted with -F, -Cl, - OH, -NH2, -CN; and C1-3 alkyl optionally substituted with one or more substituents independently selected from -F and -Cl. In some embodiments, R15is hydrogen; and R16is selected from C4-6 alkyl; and Ci alkyl substituted with C3-6 carbocycle or 3- to 6-membered heterocycle. In some embodiments, R15is hydrogen, and R16is selected from C4 alkyl and Ci alkyl substituted with C3-6carbocycle. In some embodiments, R15is hydrogen; and R16is selected from A ~ ~ and -J-™

[0146] In some embodiments, R16is selected from: hydrogen; halogen, -C(O)R20d, -C(O)N(R20d)2, -C(O)OR20d, -S(O)R20d, -S(O)2R20d, -NO2, -N3, and -CN; Ci-6alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independentlyrbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19c; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20d, -SR20d, -N(R20d)2, -C(O)R20d, -C(O)N(R20d)2, -N(R20d)C(O)R20d- N(R20d)C(O)N(R20d)2, -OC(O)N(R20d)2, -N(R20d)C(O)OR20d, -C(O)OR20d, -OC(O)R20d, -S(O)R20d, - S(O)2R20d, -N02, =0, =S, =N(R20d), -N3, -CN, Ci-6 alkyl, C2.6 alkenyl, and C2.6 alkynyl, wherein Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R19c. In some embodiments, R16is selected from: halogen, -OR20d, -SR20d, -N(R20d)2, -C(O)R20d, -C(O)N(R20d)2, - N(R20d)C(O)R20d-C(O)OR20d, -OC(O)R20d, -N(R20d)C(O)N(R20d)2, -OC(O)N(R20d)2, - N(R20d)C(O)OR20d, -S(O)R20d, -S(O)2R20d, -N02, -N3, and -CN; Ci-6alkyl, C2.6alkenyl, and C2.6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20d, -SR20d, -N(R20d)2, -C(O)R20d, -C(O)N(R20d)2, -N(R20d)C(O)R20d-C(O)OR20d, - OC(O)R20d, -N(R20d)C(O)N(R20d)2, -OC(O)N(R20d)2, -N(R20d)C(O)OR20d, -S(O)R20d, -S(O)2R20d, - N02, =0, =S, =N(R20d), -N3, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R19c; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20d, -SR20d, -N(R20d)2, -C(O)R20d, -C(O)N(R20d)2, -N(R20d)C(O)R20d- N(R20d)C(O)N(R20d)2, -OC(O)N(R20d)2, -N(R20d)C(O)OR20d, -C(O)OR20d, -OC(O)R20d, -S(O)R20d, - S(O)2R20d, -N02, =0, =S, =N(R20d), -N3, -CN, Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R19c; or R16together with R15form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R19c. In some embodiments, R16is selected from: Ci alkyl, substituted with one or more substituents independently selected from: C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10- membered heterocycle is optionally substituted with one or more substituents independently selected from fluoro, -OH, -O( / Bu), Ci alkyl, C4 alkyl (e.g., -tBu), and -CF3. In some embodiments, R16is selected from: Ci alkyl, substituted with one substituent selected from: C3-10 carbocycle and 3- to 10- membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from fluoro, -OH, -O( / Bu), Ci alkyl, -tBu, and -CF3. In some embodiments, R16is selected from: Ci alkyl, substituted with one or more substituents independently selected from: phenyl, pyridyl (e.g., 2-pyridyl, 3- pyridyl, or 4-pyridyl), cyclopropyl, cyclobutyl, tetrahydropyranyl (e g , 4- tetrahydropyranyl),mopholino (e.g., JV-morpholino), and [l.l. l]-bicyclopentyl (e g., 1-[1.1.1]- bicyclopentyl), imidazolyl (e.g., 5-imidazolyl), thiophenyl (e.g., 2-thiophenyl), thiazolyl (e.g., 4- thiazolyl), indolyl (e.g., 2-indolyl, 3-indolyl), bicyclo[2.2. l]heptyl (e g., 1- bicyclo[2.2.1]heptyl), azabicyclo[2.2.1]heptanyl (e.g., 7-azabicyclo[2.2.1]heptanyl, e.g., 1- 7-azabicyclo[2.2.1]heptanyl), azabicyclo[2.2.2]octanyl (e.g., 2-azabicyclo[2.2.2]octanyl, e.g., 4-2-azabicyclo[2.2.2]octanyl), oxabicyclo[2.2.1]heptanyl (e g., 7-oxabicyclo[2.2.1]heptanyl e g., 13-7-oxabicyclo[2.2.1]heptanyl), oxabicyclo[2.2.2]octanyl, (e g., 2-oxabicyclo[2.2.2]octanyl, e.g., 13-2-oxabicyclo[2.2.2]octanyl), oxa-azabicyclo[3.2.1]octanyl (e.g., 8-oxa-3-azabicyclo[3.2.1]octanyl, e.g., 13-8-oxa-3- azabicyclo[3.2.1]octanyl, e.g., 3-oxa-8-azabicyclo[3.2.1]octanyl), any of which is optionally substituted (e.g., optionally substituted with one or more R19c. In some embodiments, R16is selectedfurther substituted) (e.g., optionally substituted with, e.g., optionally further substituted with, one or more substituents independently selected from R19c). In some embodiments, R16is selected from:Ci- 10 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR20d, -SR20d, -N(R20d)2, =0, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R19c. In some embodiments, R16is a methyl, ethyl, n- propyl, i-propyl, n-butyl, s-butyl, i-butyl, t-butyl, n-pentyl, tert-pentyl, neopentyl, isopentyl, secpentyl, 3-pentyl, sec-isopentyl, or 2-methylbutyl moiety, each of which is optionally substituted, e.g., with one or more substituents independently selected from R19c. In some embodiments, R16is selected from: C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20d, -SR20d, - N(R20d)2, -C(O)R20d, -C(O)N(R20d)2, -N(R20d)C(O)R20d-N(R20d)C(O)N(R20d)2, -OC(O)N(R20d)2, - N(R20d)C(O)OR20d, -C(O)OR20d, -OC(O)R20d, -S(O)R20d, -S(O)2R20d, -N02, =0, =S, =N(R20d), -N3, - CN, Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R19c. In some embodiments, R16is selected from: C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR20d, -SR20d, -N(R20d)2, =0, -CN, and Ci-6 alkyl, wherein each Ci-6 alkyl is optionally substituted with one or more substituents independently selected from R19c. In some embodiments, R16is [l .l . l]-bicyclopentyl (e.g., l-[l.l. l]bicyclopentyl), cyclopentyl, cyclohexyl, tetrahydropyranyl (e.g., 4-tetrahydropyranyl), bicyclo[2.2. I]heptyl (e.g., 1- bicyclo[2.2.1]heptyl), 7- azabicyclo[2.2.1]heptanyl (e.g., 1- 7-azabicyclo[2.2.1]heptanyl), 2-azabicyclo[2.2.2]octanyl (e.g., 4- 2-azabicyclo[2.2.2]octanyl), or 2-oxabicyclo[2.2.2]octanyl (e.g., 13-2-oxabicyclo[2.2.2]octanyl). In(e.g. optionally further substituted) (e.g., optionally substituted with, e.g., optionally further substituted with, one or more substituents independently selected from R19c). In some embodiments,is optionally substituted (e.g., optionally substituted with one or more substituents independently selected from: R19c).

[0147] In some embodiments, for a compound or salt of Formula (III), (III- A), or (III-C), R15is selected from: hydrogen; Ci alkyl substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle; and C4-6 alkyl. In some embodiments, R15is selected from: hydrogen.

[0148] In some embodiments, for a compound or salt of Formula (III), (III- A), or (III-C), R16together with R15form a 3- to 12- membered heterocycle or C3-12 carbocycle, wherein the 3- to 12- membered heterocycle or C3-12 carbocycle is optionally substituted with one or more substituents independently selected from R19c. In some embodiments, R16together with R15form a C4-6 carbocycle. In some embodiments, R16together with R15form a 4- to 6- membered heterocycle. In some embodiments, R16together with R15form a C5 carbocycle. In some embodiments, R16together with R15form a 5- membered heterocycle.

[0149] In some embodiments, for a compound or salt of Formula (III), (III- A), or (III-C), R17is selected from: hydrogen and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR20e, -SR20e, -N(R20e)2, -NO2, and -CN. In some embodiments, R17is selected from: hydrogen and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR20e, -N(R20e)2, and -CN. In some embodiments,R17is selected from hydrogen and Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, CN, C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R17is selected from hydrogen and Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen and CN. In some embodiments, R17is selected from hydrogen, Ci-6 alkyl, and Ci-6 haloalkyl. In some embodiments, R17is selected from hydrogen and Ci-6 alkyl. In some embodiments, R17is selected from hydrogen, methyl, and -CF3. In some embodiments, R17is selected from hydrogen and methyl. In some embodiments, R17is hydrogen.

[0150] In some embodiments, for a compound or salt of Formula (III), (III- A), (III-C), e g., for a compound or salt of Formula (III), R18is selected from: hydrogen; andCi-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR20f, -SR20f, -N(R20f)2, -NO2, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle are optionally substituted with one or more substituents independently selected from halogen, -OR20f, -SR20f, -N(R20f)2, -NO2, and -CN.

[0151] In some embodiments, for a compound or salt of Formula (III), (III- A), (III-C), e.g., for a compound or salt of Formula (III), R18is selected from hydrogen; and Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR20f, -SR20f, - N(R20f)2, -NO2, and -CN. In some embodiments, R18is selected from hydrogen and Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, CN, C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R18is selected from hydrogen and Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen and CN. In some embodiments, R18is selected from hydrogen and Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen. In some embodiments, R18is selected from hydrogen, Ci-6 alkyl, and Ci- haloalkyl. In some embodiments, R18is selected from hydrogen and Ci-6 alkyl. In some embodiments, R18is selected from hydrogen.

[0152] In some embodiments, for a compound or salt of Formula (III) each R19a, R19b, and R19care is independently selected from: halogen, -OR20g, -SR20g, -N(R20g)2, -C(O)R20g, -C(O)N(R20g)2, -N(R20g)C(O)R20g- N(R20g)C(O)N(R20g)2, -OC(O)N(R20g)2, -N(R20g)C(O)OR20g, -C(O)OR20g, -OC(O)R20g, - S(O)R20g, -S(O)2R2°S, -NO2, =0, =S, =N(R20g), and -CN; andC1.3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20g, -SR20g, -

[0153] In some embodiments, for a compound or salt of Formula (III), (III- A), (III-C), e.g., for a compound or salt of Formula (III), each R19a, R19b, and R19care independently selected from: halogen, -OR20g, -SR20g, -N(R20g)2, -C(O)R20g, -C(O)N(R20g)2, -N(R20g)C(O)R20g-C(O)OR20g, - OC(O)R20g, -NO2, =0, and -CN; C1-3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR20g, -SR20g, -N(R20g)2, -C(O)R20g, -C(O)N(R20g)2, - N(R20g)C(O)R20g-C(O)OR20g, -OC(O)R20g, -N02, =0, and -CN; and C3-10 carbocycle and 3- to 10- membered heterocycle. In some embodiments, each R19a, R19b, and R19care independently selected from: each R19a, R19b, and R19care independently selected from: halogen, -OR20g, -SR20g, - N(R20g)2, -C(O)R20g, -NO2, =0, and -CN; and C1-3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR20g, -SR20g, -N(R20g)2, -C(O)R20g, -NO2, =0, and -CN. In some embodiments, each R19a, R19b, and R19care independently selected from: F, Cl, Br, -OR20g, -N(R20g)2, -NO2, =0, and -CN; and C1.3 alkyl optionally substituted with one or more substituents independently selected from F, Cl, Br, -OR20g, -N(R20g)2, -NO2, =0, and -CN. In some embodiments, each R19a, R19b, and R19care independently selected from: halogen, -OR20g, -CN, C1-3 alkyl, and C1-3 haloalkyl. In some embodiments, each R19a, R19b, and R19care independently selected from: halogen, -OH, -CN, C1-3 alkyl, and C1.3 haloalkyl. In some embodiments, each R19a, R19b, and R19Care independently selected from: F, Cl, and -CN; and C1.3 alkyl optionally substituted with one or more substituents independently selected from F, Cl, and -CN. In some embodiments, each R19a, R19b, and R19care independently selected from: F, Cl, -CN, and C1-3 alkyl. In some embodiments, each R19a, R19b, and R19care independently selected from: F, Cl, -CN; and methyl. In some embodiments, each R19a, R19b, and R19care independently selected from: F and -CN. In some embodiments, each R19a, R19b, and R19care F. In some embodiments, each R19a, R19b, and R19care - CN.

[0154] In some embodiments, for a compound or salt of Formula (III), (III- A), (III-C), e.g., for a compound or salt of Formula (III), each R19ais independently selected from: halogen, -OR20g, -SR20g, -N(R20g)2, -C(O)R20g, -C(O)N(R20g)2, -N(R20g)C(O)R20g- N(R20g)C(O)N(R20g)2, -OC(O)N(R20g)2, -N(R20g)C(O)OR20g, -C(O)OR20g, -OC(O)R20g, - S(O)R20g, -S(O)2R20g, -NO2, =0, =S, =N(R20g), and -CN; andCi-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20g, -SR20g, - N(R20g)2, -C(O)R20g, -C(O)N(R20g)2, -N(R20g)C(O)R20g-N(R20g)C(O)N(R20g)2, -OC(O)N(R20S)2, -N(R20g)C(O)OR20g, -C(O)OR20g, -OC(O)R20g, -S(O)R20g, -S(O)2R20g- N02, =0, =S, =N(R20g), and -CN.

[0155] In some embodiments, each R19ais independently selected from: halogen, -OR20g, -SR20g, - N(R20§)2, -C(O)R20g, -C(O)N(R20g)2, -N(R20g)C(O)R20g-C(O)OR20g, -OC(O)R20g, -NO2, =0, and - CN; Ci-3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR20g, -SR20g, -N(R20g)2, -C(O)R20g, -C(O)N(R20g)2, -N(R20g)C(O)R20g-C(O)OR20g, - OC(O)R20g, -NO2, =0, and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, each R19ais independently selected from: each R19ais independently selected from: halogen, -OR20g, -SR20g, -N(R20g)2, -C(O)R20g, -N02, =0, and -CN; and C1.3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR20g, -SR20g, - N(R20g)2, -C(O)R20g, -NO2, =0, and -CN. In some embodiments, each R19ais independently selected from: F, Cl, Br, -OR20g, -N(R20g)2, -NO2, =0, and -CN; and C1-3 alkyl optionally substituted with one or more substituents independently selected from F, Cl, Br, -OR20g, -N(R20g)2, -NO2, =0, and -CN. In some embodiments, each R19ais independently selected from: halogen, -OR20g, -CN, C1.3 alkyl, and C1.3 haloalkyl. In some embodiments, each R19ais independently selected from: halogen, --0H, -CN, Ci-3 alkyl, and C1-3 haloalkyl. In some embodiments, each R19ais independently selected from: F, Cl, and -CN; and C1-3 alkyl optionally substituted with one or more substituents independently selected from F, Cl, and -CN. In some embodiments, each R19ais independently selected from: F, Cl, -CN, and C1-3 alkyl. In some embodiments, each R19ais independently selected from: F, Cl, -CN; and methyl. In some embodiments, each R19ais independently selected from: F and -CN. In some embodiments, each R19ais independently selected from: F. In some embodiments, each R19ais independently selected from: -CN.

[0156] In some embodiments, for a compound or salt of Formula (III), (III- A), (III-C), e.g., for a compound or salt of Formula (III), each R19his independently selected from: halogen, -OR20g, -SR20g, -N(R20g)2, -C(O)R20g, -C(O)N(R20g)2, -N(R20g)C(O)R20g- N(R20g)C(O)N(R20g)2, -OC(O)N(R20g)2, -N(R20g)C(O)OR20g, -C(O)OR20g, -OC(O)R20g, - S(O)R20g, -S(O)2R20g, -NO2, =0, =S, =N(R20g), and -CN; andC1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20g, -SR20g, - N(R20g)2, -C(O)R20g, -C(O)N(R20g)2, -N(R20g)C(O)R20g-N(R20g)C(O)N(R20g)2, - OC(O)N(R20g)2, -N(R20g)C(O)OR20g, -C(O)OR20g, -OC(O)R20g, -S(O)R20g, -S(O)2R20g, - NO2, =0, =S, =N(R20g), and -CN.

[0157] In some embodiments, each R19bis independently selected from: halogen, -OR20g, -SR20g, - N(R20g)2, -C(O)R20g, -C(O)N(R20g)2, -N(R20g)C(O)R20g-C(O)OR20g, -OC(O)R20g, -N02, =0, and -CN; Ci-3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR20g, -SR20g, -N(R20g)2, -C(O)R20g, -C(O)N(R20g)2, -N(R20g)C(O)R20g-C(O)OR20g, - OC(O)R20g, -NO2, =0, and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, each R19bis independently selected from: each R19bis independently selected from: halogen, -OR20g, -SR20g, -N(R20g)2, -C(O)R20g, -NO2, =0, and -CN; and C1.3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR20g, -SR20g, - N(R20g)2, -C(O)R20g, -NO2, =0, and -CN. In some embodiments, each R19bis independently selected from: F, Cl, Br, -OR20g, -N(R20g)2, -NO2, =0, and -CN; and C1-3 alkyl optionally substituted with one or more substituents independently selected from F, Cl, Br, -OR20g, -N(R20g)2, -NO2, =0, and -CN. In some embodiments, each R19bis independently selected from: halogen, -OR20g, -CN, C1-3 alkyl, and C1-3 haloalkyl. In some embodiments, each R19bis independently selected from: halogen, —OH, -CN, C1-3 alkyl, and C1-3 haloalkyl. In some embodiments, each R19bis independently selected from: F, Cl, and -CN; and C1-3 alkyl optionally substituted with one or more substituents independently selected from F, Cl, and -CN. In some embodiments, each R19bis independently selected from: F, Cl, -CN, and C1-3 alkyl. In some embodiments, each R19bis independently selected from: F, Cl, -CN; and methyl. In some embodiments, each R19bis independently selected from: F and -CN. In some embodiments, each R19bis F. In some embodiments, each R19bis -CN.

[0158] In some embodiments, for a compound or salt of Formula (III), (III- A), (III-C), e.g., for a compound or salt of Formula (III), each R19cis independently selected from: halogen, -OR20g, -SR20g, -N(R20g)2, -C(O)R20g, -C(O)N(R20g)2, -N(R20g)C(O)R20g- N(R20g)C(O)N(R20g)2, -OC(O)N(R20g)2, -N(R20g)C(O)OR20g, -C(O)OR20g, -OC(O)R20g, - S(O)R20g, -S(O)2R20g, -N02, =0, =S, =N(R20g), and -CN; andC1-3 alkyl, C2.3alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20g, -SR20g, - N(R20g)2, -C(O)R20g, -C(O)N(R20g)2, -N(R20g)C(O)R20g-N(R20g)C(O)N(R20g)2, - OC(O)N(R20g)2, -N(R20g)C(O)OR20g, -C(O)OR20g, -OC(O)R20g, -S(O)R20g, -S(O)2R20g, - N02, =0, =S, =N(R20g), and -CN.

[0159] In some embodiments, each R19cis independently selected from: halogen, -OR20g, -SR20g, - N(R20g)2, -C(O)R20g, -C(O)N(R20g)2, -N(R20g)C(O)R20g-C(O)OR20g, -OC(O)R20g, -N02, =0, and - CN; C1-3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR20g, -SR20g, -N(R20g)2, -C(O)R20g, -C(O)N(R20g)2, -N(R20g)C(O)R20g-C(O)OR20g, - OC(O)R20g, -N02, =0, and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle.

[0160] In some embodiments, each R19cis independently selected from: each R19cis independently selected from: halogen, -OR20g, -SR20g, -N(R20g)2, -C(O)R20g, -NO2, =0, and -CN; and C1-3 alkyloptionally substituted with one or more substituents independently selected from halogen, -OR20g, - SR20g, -N(R20g)2, -C(O)R20g, -NO2, =0, and -CN. In some embodiments, each R19cis independently selected from: F, Cl, Br, -OR20g, -N(R20g)2, -NO2, =0, and -CN; and C1.3 alkyl optionally substituted with one or more substituents independently selected from F, Cl, Br, -OR20g, -N(R20g)2, -NO2, =0, and -CN. In some embodiments, each R19cis independently selected from: halogen, -OR20g, -CN, Ci- 3 alkyl, and C1.3 haloalkyl. In some embodiments, each R19cis independently selected from: halogen, —OH, -CN, C1-3 alkyl, and C 1-3 haloalkyl. In some embodiments, each R19cis independently selected from: F, Cl, and -CN; and C1.3 alkyl optionally substituted with one or more substituents independently selected from F, Cl, and -CN. In some embodiments, each R19cis independently selected from: F, Cl, -CN, and C1-3 alkyl. In some embodiments, each R19cis independently selected from: F, Cl, -CN; and methyl. In some embodiments, each R19cis independently selected from: F and -CN. In some embodiments, each R19cis independently selected from: F. In some embodiments, each R19Cis independently selected from: -CN.

[0161] In some embodiments, for a compound or salt of Formula (III), (III- A), (III-C), e.g., for a compound or salt of Formula (III), each R20a, R20b, R20c, R20d, R20e, R20f, and R20gis independently selected from: hydrogen;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, - SH, -NO2, -NH2, =0, =S, -O-C1.6 alkyl, -S-Ci-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl.

[0162] In some embodiments, each R20a, R20b, R20c, R20d, R20e, R20f, and R20gis independently selected from hydrogen, C1-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the Ci-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, and -NH2. In some embodiments, each R20a, R20b, R20c, R20d, R20e, R20f, and R20gis independently selected from hydrogen; and Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, and -NH2. In some embodiments, each R20a, R20b, R20c, R20d, R20e, R20f, and R20gis independently selected from hydrogen, C1-3 alkyl, and C1-3 haloalkyl.In some embodiments, for a compound or salt of Formula (III), (III- A), (III-C), e.g., for a compound or salt of Formula (III), each R20ais independently selected from: hydrogen; and Ci-g alkyl optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci- 6 alkyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-6 haloalkyl. In some embodiments, each R20ais independently selected from hydrogen; and Ci-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2,and =0; and C3- 10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, - C1-6 alkyl, and C1-6 haloalkyl. In some embodiments, R20ais independently selected from hydrogen; and Ci-6 alkyl optionally substituted with one or more substituents independently selected from fluorine and chlorine; and C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R20ais independently selected from hydrogen; and Ci-6 alkyl optionally substituted with fluorine; and C3- 10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R20ais hydrogen. In some embodiments, R20ais methyl.

[0163] In some embodiments, for a compound or salt of Formula (III), (III- A), (III-C), e.g., for a compound or salt of Formula (III), each R20his independently selected from: hydrogen; and Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(Ci-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), Ci-6 alkyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-6 haloalkyl. In some embodiments, each R20bis independently selected from hydrogen; and Ci-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2,and =0; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, - Ci-6 alkyl, and C 1-6 haloalkyl. In some embodiments, R20bis independently selected from hydrogen; and Ci-6 alkyl optionally substituted with one or more substituents independently selected from fluorine and chlorine; and C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R20bis independently selected from hydrogen; and Ci-6 alkyloptionally substituted with fluorine; and C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R20bis hydrogen. In some embodiments, R20bis methyl.

[0164] In some embodiments, for a compound or salt of Formula (III), (III- A), (III-C), e g., for a compound or salt of Formula (III), each R20cis independently selected from: hydrogen; and Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1.6 alkyl, -S-Ci-6 alkyl, -N(CI-6alkyl)2, -NH(CI_6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), Ci-6 alkyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-6 haloalkyl. In some embodiments, each R20cis independently selected from hydrogen; and Ci-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2,and =0; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -N02, -NH2, =0, - Ci-6 alkyl, and C 1-6 haloalkyl. In some embodiments, R20cis independently selected from hydrogen; and Ci-6 alkyl optionally substituted with one or more substituents independently selected from fluorine and chlorine; and C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R20cis independently selected from hydrogen; and Ci-6 alkyl optionally substituted with fluorine; and C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R20cis hydrogen. In some embodiments, R20cis methyl.

[0165] In some embodiments, for a compound or salt of Formula (III), (III- A), (III-C), e.g., for a compound or salt of Formula (III), each R20dis independently selected from: hydrogen; and Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-Ci-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-Ci-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), Ci-6 alkyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-6 haloalkyl. In some embodiments, each R20dis independently selected from hydrogen; and Ci-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -N02, -NH2,and =0; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -N02, -NH2, =0, - Ci-6 alkyl, and C 1-6 haloalkyl. In some embodiments, R20dis independently selected from hydrogen; and Ci-6 alkyl optionally substituted with one or more substituentsindependently selected from fluorine and chlorine; and C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R20dis independently selected from hydrogen; and Ci-6 alkyl optionally substituted with fluorine; and C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R20dis hydrogen. In some embodiments, R20dis methyl.

[0166] In some embodiments, for a compound or salt of Formula (III), (III- A), (III-C), e.g., for a compound or salt of Formula (III), each R20eis independently selected from: hydrogen; and Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-Ci-6alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, O, =S, -O-C1-6 alkyl, -S-Ci-6alkyl, -N(CI-6alkyl)2, -NH(CI-6 alkyl), Ci-6 alkyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-6 haloalkyl. In some embodiments, each R20eis independently selected from hydrogen; and Ci-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2,and =0; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, O, - Ci-6 alkyl, and C 1-6 haloalkyl. In some embodiments, R20eis independently selected from hydrogen; and Ci-6 alkyl optionally substituted with one or more substituents independently selected from fluorine and chlorine; and C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R20eis independently selected from hydrogen; and Ci-6 alkyl optionally substituted with fluorine; and C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R20eis hydrogen. In some embodiments, R20eis methyl.

[0167] In some embodiments, for a compound or salt of Formula (III), (III- A), (III-C), e.g., for a compound or salt of Formula (III), each R20fis independently selected from: hydrogen; and Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-Ci-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-Ci-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), Ci-6 alkyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-6 haloalkyl. In some embodiments, each R20fis independently selected from hydrogen; and Ci-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -N02, -NH2,and =0; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH,-SH, -NO2, -NH2, =0, - C1-6 alkyl, and C 1-6 haloalkyl. In some embodiments, R20fis independently selected from hydrogen; and C1-6 alkyl optionally substituted with one or more substituents independently selected from fluorine and chlorine; and C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R20fis independently selected from hydrogen; and C1-6 alkyl optionally substituted with fluorine; and C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R20fis hydrogen. In some embodiments, R20fis methyl.

[0168] In some embodiments, for a compound or salt of Formula (III), (III- A), (III-C), e.g., for a compound or salt of Formula (III), each R20gis independently selected from: hydrogen; and Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), Ci-6 alkyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-6 haloalkyl. In some embodiments, each R20gis independently selected from hydrogen; and Ci-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2,and =0; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, - Ci-6 alkyl, and C 1-6 haloalkyl. In some embodiments, R20gis independently selected from hydrogen; and Ci-6 alkyl optionally substituted with one or more substituents independently selected from fluorine and chlorine; and C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R20gis independently selected from hydrogen; and Ci-6 alkyl optionally substituted with fluorine; and C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R20gis hydrogen. In some embodiments, R20gis methyl.

[0169] In some embodiments, for a compound or salt of Formula (III), (III- A), (III-C), e.g., for a compound or salt of Formula (III), each R20his independently selected from:Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6 alkyl)2, -NH(CI-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - CN, -OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci- 6 alkyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-6 haloalkyl. In some embodiments, each R20his independently selected from Ci-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2,and =0; and C3-10carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =0, - C1-6 alkyl, and Ci-6 haloalkyl. In some embodiments, R20his independently selected from Ci-6 alkyl optionally substituted with one or more substituents independently selected from fluorine and chlorine; and C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R20his independently selected from C1-6 alkyl optionally substituted with fluorine; and C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R20his methyl.

[0170] In some embodiments, a compound or salt of Formula (III), (III-A), or Formula (III-C), e g., Formula (III), is selected from a compound of Table 2, or a salt thereof.

[0171] In another aspect, disclosed herein is a compound represented by Formula (IV-C):or a salt thereof, wherein:X21, X22, X23, and X24are each independently selected from C(R21) and N;Ring B is a 3- to 10- membered spirocyclic heterocycle or C3-10 spirocyclic carbocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR30c, -SR30c, -N(R30c)2, -C(O)R30c, -C(O)N(R30c)2, - N(R30c)C(O)R30c, -C(O)OR30C, -OC(O)R30C, -N(R30C)C(O)N(R30C)2, -OC(O)N(R30C)2, - N(R30c)C(O)OR30c, -S(O)R30C, -S(O)2R30C, -NO2, =0, =S, =N(R30C), and -CN;Ci-6 alkyl, C2.6 alkenyl, and C2.6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30c, -SR30c, - N(R30c)2, -C(O)R30C, -C(O)N(R30C)2, -N(R30C)C(O)R30C, -C(O)OR30C, -OC(O)R30C, - N(R30C)C(O)N(R30C)2, -OC(O)N(R30C)2, -N(R30C)C(O)OR30C, -S(O)R30C, -S(O)2R30C, -NO2, =0, =S, =N(R30c), -CN, C3-io carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R29c; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30c, - SR30C, -N(R30C)2, -C(O)R30C, -C(O)N(R30C)2, -N(R30C)C(O)R30C, -N(R30C)C(O)N(R30C)2, - OC(O)N(R30C)2, -N(R30C)C(O)OR30C, -C(O)OR30C, -OC(O)R30C, -S(O)R30C, -S(O)2R30C, -NO2, =0, =S, =N(R30C), -CN, CI-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R29c; each R21is independently selected from: hydrogen; halogen, -N02, -CN, -OR30a, -SR30a, -N(R30a)2, -C(O)R30a, -C(O)N(R30a)2, - N(R30a)C(O)R30a-N(R30a)C(O)N(R30a)2, -OC(O)N(R30a)2, - N(R30a)C(O)OR30a, -C(O)OR30a, -OC(O)R30a, -S(O)R30a, and -S(O)2R30a;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30a, -SR30a, - N(R30a)2, -C(O)R30a, -C(O)N(R30a)2, -N(R30a)C(O)R30a, -C(O)OR30a, -OC(O)R30a, - N(R30a)C(O)N(R30a)2, -OC(O)N(R30a)2, -N(R30a)C(O)OR30a, -S(O)R30a, -S(O)2R30a, -NO2, =0, =S, =N(R30a), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R29a; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30a, - SR30a, -N(R30a)2, -C(O)R30a, -C(O)N(R30a)2, -N(R30a)C(O)R30a, -N(R30a)C(O)N(R30a)2, - OC(O)N(R30a)2, -N(R30a)C(O)OR30a, -C(O)OR30a, -OC(O)R30a, -S(O)R30a, -S(O)2R30a, - NO2, =0, =S, =N(R30a), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R29a;R22is selected from:Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30b, -SR30b, - N(R30b)2, -C(O)R30b, -C(O)N(R30b)2, -N(R30b)C(O)R30b-C(O)OR30b, -OC(O)R30b, - N(R30b)C(O)N(R30b)2, -OC(O)N(R30b)2, -N(R30b)C(O)OR30b, -S(O)R30b, -S(O)2R30b, -N02, =0, =S, =N(R30b), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R29b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30b, - SR30b, -N(R30h)2, -C(O)R30b, -C(O)N(R30b)2, -N(R30b)C(O)R30b-N(R30b)C(O)N(R30b)2, - OC(O)N(R30b)2, -N(R30b)C(O)OR30b, -C(O)OR30b, -OC(O)R30b, -S(O)R30b, -S(O)2R30b, - N02, =0, =S, =N(R30h), -CN, Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R29b;or R22together with R27form a 3- to 20-membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OR30b, -SR30b, -N(R30b)2, -C(O)R30b, -C(O)N(R30b)2, - N(R30b)C(O)R30b-C(O)OR30b, -OC(O)R30b, -N(R30b)C(O)N(R30b)2, -OC(O)N(R30b)2, - N(R30b)C(O)OR30b, -S(O)R30b, -S(O)2R30b, -NO2, =0, =S, =N(R30b), and -CN;Ci-6 alkyl, C2.6 alkenyl, and C2.6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR30b, -SR30b, -N(R30b)2, -C(O)R30b, -C(O)N(R30b)2, -N(R30b)C(O)R30b-C(O)OR30b, - OC(O)R30b, -N(R30b)C(O)N(R30b)2, -OC(O)N(R30b)2, -N(R30b)C(O)OR30b, -S(O)R30b, - S(O)2R30b, -NO2, =0, =S, =N(R30b), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R29b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30b, -SR30h, -N(R30h)2, -C(O)R30b, -C(O)N(R30b)2, -N(R30b)C(O)R30b- N(R30b)C(O)N(R30b)2, -OC(O)N(R30b)2, -N(R30b)C(O)OR30b, -C(O)OR30b, -OC(O)R30b, -S(O)R30b, -S(O)2R30b, -NO2, -O, =S, -N(R30b), -CN, Ci-6alkyl, C2.6alkenyl, and C2.6alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more R29b; each R25and R26are independently selected from: hydrogen, halogen, -OR30d, -SR30d, -N(R30d)2, -NO2, and -CN;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30d, -SR30d, - N(R30d)2, -C(O)R30d, -C(O)N(R30d)2, -N(R30d)C(O)R30d-C(O)OR30d, -OC(O)R30d, - N(R30d)C(O)N(R30d)2, -OC(O)N(R30d)2, -N(R30d)C(O)OR30d, -S(O)R30d, -S(O)2R30d, -N02, =0, =S, =N(R30d), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R29c; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30d, - SR30d, -N(R30d)2, -N02, and -CN; orR25together with R26form a 3 - to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more R29c,R27is selected from: hydrogen and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR30e, -SR30e, -N(R30e)2, -NO2, and -CN;R28is selected from: hydrogen; andCi-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR30f, -SR30f, -N(R30f)2, -NO2, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle are optionally substituted with one or more substituents independently selected from halogen, -OR30f, -SR30f, -N(R30f)2, -NO2, and -CN; each R29a, R29b, and R29cis independently selected from:C1.3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30g, -SR30g, - N(R30g)2, -C(O)R30g, -C(O)N(R30g)2, -N(R30g)C(O)R30g-N(R30g)C(O)N(R30g)2, - OC(O)N(R30g)2, -N(R30g)C(O)OR30g, -C(O)OR30g, -OC(O)R30g, -S(O)R30g, -S(O)2R30g, - NO2, =0, =S, =N(R30g), and -CN; and each R30a, R30b, R30c, R30d, R30e, R30f, and R30gis independently selected from: hydrogen;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-Ci-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1.6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-s haloalkyl.

[0172] In another aspect, disclosed herein is a compound represented by Formula (IV):or a salt thereof, wherein:X21, X22, X23, and X24are each independently selected from C(R21) and N;Ring B is a 5- to 10- membered spirocyclic heterocycle or C5-10 spirocyclic carbocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR30c, -SR30c, -N(R30c)2, -C(O)R30c, -C(O)N(R30c)2, - N(R30c)C(O)R30c, -C(O)OR30C, -OC(O)R30C, -N(R30C)C(O)N(R30C)2, -OC(O)N(R30C)2, - N(R30c)C(O)OR30c, -S(O)R30C, -S(O)2R30C, -NO2, =0, =S, =N(R30C), and -CN;Ci-6 alkyl, C2-6 alkenyl, and C2.6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30c, -SR30c, - N(R30c)2, -C(O)R30C, -C(O)N(R30C)2, -N(R30C)C(O)R30C, -C(O)OR30C, -OC(O)R30C, - N(R30c)C(O)N(R30c)2, -OC(O)N(R30C)2, -N(R30C)C(O)OR30C, -S(O)R30C, -S(O)2R30C, -NO2, =0, =S, =N(R30C), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R29c; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30c, - SR30C, -N(R30C)2, -C(O)R30C, -C(O)N(R30C)2, -N(R30C)C(O)R30C, -N(R30C)C(O)N(R30C)2, - OC(O)N(R30C)2, -N(R30C)C(O)OR30C, -C(O)OR30C, -OC(O)R30C, -S(O)R30C, -S(O)2R30C, - NO2, =0, =S, =N(R30C), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R29c; each R21is independently selected from: hydrogen; halogen, -NO2, -CN, -OR30a, -SR30a, -N(R30a)2, -C(O)R30a, -C(O)N(R30a)2, - N(R30a)C(O)R30a, -N(R30a)C(O)N(R30a)2, -OC(O)N(R30a)2, - N(R30a)C(O)OR30a, -C(O)OR30a, -OC(O)R30a, -S(O)R30a, and -S(O)2R30a;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30a, -SR30a, - N(R30a)2, -C(O)R30a, -C(O)N(R30a)2, -N(R30a)C(O)R30a, -C(O)OR30a, -OC(O)R30a, - N(R30a)C(O)N(R30a)2, -OC(O)N(R30a)2, -N(R30a)C(O)OR30a, -S(O)R30a, -S(O)2R30a, -NO2,=0, =S, =N(R30a), -CN, C3-io carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R29a; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30a, - SR30a, -N(R30a)2, -C(O)R30a, -C(O)N(R30a)2, -N(R30a)C(O)R30a, -N(R30a)C(O)N(R30a)2, - OC(O)N(R30a)2, -N(R30a)C(O)OR30a, -C(O)OR30a, -OC(O)R30a, -S(O)R30a, -S(O)2R30a, - NO2, =0, =S, =N(R30a), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2.6 alkenyl, and C2.6 alkynyl are each optionally substituted with one or more R29a;R22is selected from:Ci-6 alkyl, C2-6 alkenyl, and C2-e alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30b, -SR30b, - N(R30b)2, -C(O)R30b, -C(O)N(R30b)2, -N(R30b)C(O)R30b-C(O)OR30b, -OC(O)R30b, - N(R30b)C(O)N(R30b)2, -OC(O)N(R30b)2, -N(R30b)C(O)OR30b, -S(O)R30b, -S(O)2R30b, -N02, =0, =S, =N(R30b), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R29b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30b, - SR30b, -N(R30h)2, -C(O)R30b, -C(O)N(R30b)2, -N(R30b)C(O)R30b-N(R30b)C(O)N(R30b)2, - OC(O)N(R30b)2, -N(R30b)C(O)OR30b, -C(O)OR30h, -OC(O)R30b, -S(O)R30b, -S(O)2R30b, - N02, =0, =S, =N(R30h), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R29b; each R25and R26are independently selected from: hydrogen, halogen, -OR30d, -SR30d, -N(R30d)2, -N02, and -CN;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30d, -SR30d, - N(R30d)2, -C(O)R30d, -C(O)N(R30d)2, -N(R30d)C(O)R30d-C(O)OR30d, -OC(O)R30d, - N(R30d)C(O)N(R30d)2, -OC(O)N(R30d)2, -N(R30d)C(O)OR30d, -S(O)R30d, -S(O)2R30d, -N02, =0, =S, =N(R30d), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R29c; andCa-io carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30d, - SR30d, -N(R30d)2, -NO2, and -CN; orR25together with R26form a 3 - to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more R29c,R27is selected from: hydrogen and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR30e, -SR30e, -N(R30e)2, -NO2, and -CN;R28is selected from: hydrogen; andCi-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR30f, -SR30f, -N(R30f)2, -NO2, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle are optionally substituted with one or more substituents independently selected from halogen, -OR30f, -SR30f, -N(R30f)2, -NO2, and -CN; each R29a, R29b, and R29care independently selected from: halogen, -OR30g, -SR30g, -N(R30g)2, -C(O)R30g, -C(O)N(R30g)2, -N(R30g)C(O)R30g- N(R30g)C(O)N(R30g)2, -OC(O)N(R30g)2, -N(R30g)C(O)OR30g, -C(O)OR30g, -OC(O)R30g, - S(O)R30g, -S(O)2R30g, -NO2, =0, =S, =N(R30g), and -CN; andC1.3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30g, -SR30g, - N(R30g)2, -C(O)R30g, -C(O)N(R30g)2, -N(R30g)C(O)R30g-N(R30g)C(O)N(R30g)2, - OC(O)N(R30g)2, -N(R30g)C(O)OR30g, -C(O)OR30g, -OC(O)R30g, -S(O)R30g, -S(O)2R30g, - NO2, =0, =S, =N(R30g), and -CN; each R30a, R30b, R30c, R30d, R30e, R30f, and R30gare independently selected from: hydrogen;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-Ci-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1.6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-e haloalkyl.

[0173] In another aspect, disclosed herein is a compound of Formula (IV) represented by Formula (IV-A):or a salt thereof, wherein:X21, X22, X23, and X24are each independently selected from C(R21) and N;Ring B is a 5- to 10- membered spirocyclic heterocycle or C5-10 spirocyclic carbocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR30c, -SR30c, -N(R30c)2, -C(O)R30c, -C(O)N(R30c)2, -NO2, =0 and -CN;Ci-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR30c, -SR30c, -N(R30c)2, -C(O)R30c, -C(O)N(R30c)2, -NO2, =0, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R29c; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30c, - N(R30c)2, -C(O)R30C, -C(O)N(R30C)2, -NO2, =0, =S, =N(R30C), and -CN; and Ci-6alkyl, optionally substituted with one or more R29c; each R21is independently selected from: hydrogen; halogen, -N02, -CN, -OR30a, -SR30a, -N(R30a)2, -C(O)R30a, -C(O)N(R30a)2;Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR30a, -SR30a, -N(R30a)2, -C(O)R30a, -N02, =0, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10- membered heterocycle are each optionally substituted with one or more R29a; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30a, - N(R30a)2, and -CN; and Ci-6 alkyl, optionally substituted with one or more R29a;R22is selected from:Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR30b, -SR30b, -N(R30b)2, -C(O)R30b, -C(O)N(R30b)2, -NO2, =0, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R29b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30b, - SR30b, -N(R30h)2, -NO2, =0, -CN; and Ci-6 alkyl optionally substituted with one or more R29b; each R25and R26are independently selected from: hydrogen, halogen, -OR30d, -SR30d, -N(R30d)2, -NO2, and -CN;Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR30d, -SR30d, -N(R30d)2, -C(O)R30d, -C(O)N(R30d)2-NO2,O, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R29c; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30d, - SR30d, -N(R30d)2, -NO2, and -CN;R27is selected from: hydrogen and Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR30e, -N(R30e)2, and -CN;R28is selected from: hydrogen; and Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR30f, - -N(R30f)2, and -CN; each R29a, R29b, and R29care independently selected from halogen, -N(R30g)2, -C1.3 alkyl, and C1.3 haloalkyl; and each R30a, R30b, R30c, R30d, R30e, R30f, and R30gare independently selected from hydrogen, Ci-6 alkyl, and Ci-6 haloalkyl.

[0174] In some embodiments, for a salt or compound of Formula (IV), wherein the compound is not

[0175] In some embodiments, for a compound or salt of Formula (IV), (IV-A), or (IV-C), e.g., for a compound or salt of Formula (IV), at least one of X21, X22, X23, or X24is N. In some embodiments, at least two of X21, X22, X23, or X24is N. In some embodiments, at least one of X21, X22, X23, or X24is N, and no more than two of X21, X22, X23, and X24are N. In some embodiments, X21, X22, X23, and X24are each C(R21). In some embodiments, one of X21, X22, X23, or X24is N. In some embodiments, two of X21, X22, X23, and X24are N. In some embodiments, three of X21, X22, X23, and X24are N. In some embodiments, at least one of X21, X22, X23, or X24is C(R21). In some embodiments, at least two of X21, X22, X23, and X24are C(R21). In some embodiments, at least three of X21, X22, X23, and X24are C(R21). In some embodiments, three of X21, X22, X23, and X24are N. In some embodiments, one of X21, X22, X23, or X24is C(R21). In some embodiments, two of X21, X22, X23, and X24are C(R21). In some embodiments, three of X21, X22, X23, and X24are C(R21). In some embodiments, four of X21, X22, X23, and X24are C(R21). In some embodiments, X21is N. In some embodiments, X22is N. In some embodiments, X23is N. In some embodiments, X24is N. In some embodiments, X21is C(R21). In some embodiments, X22is C(R21). In some embodiments, X23is C(R21). In some embodiments, X24is C(R21). In some embodiments, X21is C(H). In some embodiments, X21is C(H) or C(F). In some embodiments, X22is C(H). In some embodiments, X22is C(H) or C(F).In some embodiments, X23is C(H). In some embodiments, X24is C(H). In some embodiments, X23is C(H), and X24is C(H). In some embodiments, X21is N, and X22, X23, and X24are C(R21). In some embodiments, X22is N, and X21, X23, and X24are C(R21). In some embodiments, X23is N, and X21, X22, and X24are C(R21). In some embodiments, X24is N, and X21, X22, and X23are C(R21). In some embodiments, X21is N, and X22, X23, and X24are C(H). In some embodiments, X22is N, and X21, X23, and X24are C(H). In some embodiments, X23is N, and X21, X22, and X24are C(H). In some embodiments, X24is N, and X21, X22, and X23are C(H).

[0176] In certain embodiments, for a compound or salt of Formula (IV), (IV-A), or (IV-C), e.g., for a compound or salt of Formula (IV), each R21is independently selected from: hydrogen; halogen, -NO2, -CN, -OR30a, -SR30a, -N(R30a)2, -C(O)R30a, -C(O)N(R30a)2, - N(R30a)C(O)R30a-N(R30a)C(O)N(R30a)2, -OC(O)N(R30a)2, -N(R30a)C(O)OR30a, -C(O)OR30a, - OC(O)R30a, -S(O)R30a, and -S(O)2R30a;Ci-6 alkyl, C2-6 alkenyl, and C2.6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30a, -SR30a, - N(R30a)2, -C(O)R30a, -C(O)N(R30a)2, -N(R30a)C(O)R30a-C(O)OR30a, -OC(O)R30a, - N(R30a)C(O)N(R30a)2, -OC(O)N(R30a)2, -N(R30a)C(O)OR30a, -S(O)R30a, -S(O)2R30a, -NO2, =0, =S, =N(R30a), -CN, C3-io carbocycle and 3- to 10-membered heterocycle, wherein the C3-10carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R29a; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30a, - SR30a, -N(R30a)2, -C(O)R30a, -C(O)N(R30a)2, -N(R30a)C(O)R30a-N(R30a)C(O)N(R30a)2, - OC(O)N(R30a)2, -N(R30a)C(O)OR30a, -C(O)OR30a, -OC(O)R30a, -S(O)R30a, -S(O)2R30a, -NO2, =0, =S, =N(R30a), -CN, Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R29a.

[0177] In some embodiments, for a compound or salt of Formula (IV), (IV-A), or (IV-C), e g., for a compound or salt of Formula (IV), each R21is independently selected from: hydrogen; halogen, -OR30a, -SR30a, -N(R30a)2, -C(O)R30a, -C(O)N(R30a)2, -NO2, and - CN;Ci-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR30a, -SR30a, -N(R30a)2, -C(O)R30a, -NO2, -CN, C3-10 carbocycle and 3- to 10- membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R29a; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30a, - SR30a, -N(R30a)2, -C(O)R30a, -C(O)N(R30a)2, -NO2, -CN; and Ci-6alkyl optionally substituted with one or more R29a.

[0178] In some embodiments, each R21is independently selected from: hydrogen; halogen, -OR30a, - SR30a, -N(R30a)2, -C(O)R30a, -C(O)N(R30a)2, -NO2, and -CN; Ci-6alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR30a, -SR30a, and -N(R30a)2; and C3- 10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30a, -SR30a, and -N(R30a)2. In some embodiments, each R21is independently selected from: hydrogen, halogen, -OR30a, -SR30a, - N(R30a)2, -C(O)R30a, -C(O)N(R30a)2, -NO2, and -CN;CI-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR30a, -N(R30a)2, and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30a, -N(R30a)2, and -CN. In some embodiments, each R21is independently selected from: hydrogen, halogen, -OR30a, -SR30a, - N(R30a)2, -C(O)R30a, -C(O)N(R30a)2, -NO2, and -CN; and Ci-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR30a, -SR30a, -N(R30a)2, -C(O)R30a, - C(O)N(R30a)2, -NO2, and -CN. In some embodiments, each R21is independently selected from:hydrogen, halogen, -OR30a, -SR30a, -N(R30a)2, -C(O)R30a, -C(O)N(R30a)2, -NO2, and -CN; and Ci-6alkyl, optionally substituted with one or more substituents independently selected from halogen, - OR30a, -N(R30a)2, and -CN In some embodiments, each R21is independently selected from each R21is independently selected from: hydrogen, halogen, -OR30a, -SR30a, -N(R30a)2, -C(O)R30a, - C(O)N(R30a)2, -NO2, -CN, Ci-6 alkyl, and Ci-6 haloalkyl. In some embodiments, each R21is independently selected from hydrogen, halogen, -OR30a, -N(R30a)2, -CN, Ci-6 alkyl, and Ci-6 haloalkyl. In some embodiments, each R21is independently selected from hydrogen, F, -Cl, -OH, - NH2, -CN, -OMe, and -OCF3; and C1-3 alkyl optionally substituted with one or more substituents independently selected from -F and -Cl. In some embodiments, each R21is independently selected from hydrogen, -F, -Cl, -OH, -NH2, and CN; and C1.3 alkyl optionally substituted with one or more substituents independently selected from -F and -Cl. In some embodiments, each R21is independently selected from hydrogen, halogen, -CN, methyl, and -CF3. In some embodiments, each R21is independently selected from hydrogen, -F, -Cl, -CN, methyl, and -CF3. In some embodiments, each R21is independently selected from: hydrogen, halogen, -OR30a, -SR30a, -N(R30a)2, -C(O)R30a, - C(O)N(R30a)2, -NO2, and -CN. In some embodiments, each R21is independently selected from hydrogen, halogen, -OR30a, -N(R30a)2, and -CN. In some embodiments, each R21is independently selected from hydrogen, F, -Cl, -OH, -NH2, -CN, -OMe, and -OCF3. In some embodiments, each R21is independently selected from hydrogen, -F, -Cl, -OH, -NH2, and CN. In some embodiments, each R21is independently selected from hydrogen, halogen, and -CN. In some embodiments, each R21is independently selected from hydrogen, -F, -Cl, and CN. In some embodiments, each R21is independently selected from hydrogen, -Cl, and -CN. In some embodiments, each R21is independently selected from hydrogen and -CN. In some embodiments, each R21is independently selected from hydrogen and halogen. In some embodiments, each R21is independently selected from hydrogen, -F, and -Cl. In some embodiments, each R21is independently selected from hydrogen and -F. In some embodiments, each R21is hydrogen. In some embodiments, each R21is independently selected from hydrogen and Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR30a, -N(R30a)2, -NO2, and -CN. In some embodiments, each R21is independently selected from hydrogen and Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR30a, -N(R30a)2, and -CN. In some embodiments, each R21is independently selected from hydrogen, Ci-6 alkyl, and Ci-6 haloalkyl. In some embodiments, each R21is independently selected from hydrogen, C1-3 alkyl, and C1-3 haloalkyl. In some embodiments, each R21is independently selected from hydrogen and C1.3 alkyl optionally substituted with -F and -Cl. In some embodiments, each R21is independently selected from hydrogen and methyl. In some embodiments, each R21is selected from hydrogen, C3-10 carbocycle and 3- to10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30a, -N(R30a)2, -CN, Ci-6 alkyl, and Ci-g haloalkyl. In some embodiments, each R21is selected from hydrogen, C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, Ci-g alkyl, and C1-6 haloalkyl. In some embodiments, each R21is selected from hydrogen, C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, and C1-3 alkyl optionally substituted with one or more substituents independently selected from -F and -Cl.

[0179] In some embodiments, for a compound or salt of Formula (IV), (FV-A), or (IV-C), e g., for a compound or salt of Formula (IV), Ring B is a 3- to 10- membered spirocyclic heterocycle or C3-10 spirocyclic carbocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR30c, -SR30c, -N(R30c)2, -C(O)R30c, -C(O)N(R30c)2, -NO2, =0, and -CN;C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR30c, -SR30c, -N(R30c)2, -C(O)R30c, -C(O)N(R30c)2, -NO2, =0, and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30c, - SR30C, -N(R30C)2, -C(O)R30C, -C(O)N(R30C)2, -NO2, =0, -CN, Ci-6 alkyl, and Ci-6haloalkyl.

[0180] In some embodiments, Ring B is a 3- to 10- membered spirocyclic heterocycle or C3-10 spirocyclic carbocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -CN, -NO2, -OH, -O(Ci-6 alkyl), -O(Ci-6 haloalkyl), -SH, - S(Ci-6 alkyl), -NH2, -NH(CI-6 alkyl), -N(CI-6 alkyl)2, C1-6 alkyl, and C1-6 haloalkyl. In some embodiments, Ring B is a 3 - to 10- membered spirocyclic heterocycle or C3-10 spirocyclic carbocycle, each of which is optionally substituted with one or more substituents independently selected from: -CN, -F, -Cl, -OH, -O(CH3), -O(CF3), -NH2, -NH(CH3), -N(CH3)2, -SH, -S(CH3), - CH3, and -CF3. In some embodiments, Ring B is a 3- to 10- membered spirocyclic heterocycle or C3. 10 spirocyclic carbocycle, each of which is optionally substituted with one or more substituents independently selected from: -CN, -F, -OH, -O(CH3), -NH2, -NH(CH3), -N(CH3)2, -CH3, and -CF3. In some embodiments, Ring B is a 3- to 10- membered spirocyclic heterocycle or C3-10 spirocyclic carbocycle, each of which is optionally substituted with one or more substituents independently selected from: -F, -OH, -CH3, and -CF3. In some embodiments, Ring B is a 3- to 10- membered spirocyclic heterocycle or C3-10 spirocyclic carbocycle, each of which is optionally substituted with one or more substituents independently selected from: -F and -CH3. In some embodiments, Ring B isa 3- to 10- membered spirocyclic heterocycle or C3-10 spirocyclic carbocycle, each of which is optionally substituted with one or more substituents independently selected from: -F.

[0181] In some embodiments, for a compound or salt of Formula (IV), (TV-A), or (IV-C), e g., for a compound or salt of Formula (IV), Ring B is a 5- to 10- membered spirocyclic heterocycle or C5-10 spirocyclic carbocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR30c, -SR30c, -N(R30c)2, -C(O)R30c, -C(O)N(R30c)2, -NO2, =0, and -CN;C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR30c, -SR30c, -N(R30c)2, -C(O)R30c, -C(O)N(R30c)2, -NO2, =0, and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30c, - SR30C, -N(R30C)2, -C(O)R30C, -C(O)N(R30C)2, -NO2, =0, -CN, C1.6 alkyl, and Ci-6haloalkyl.

[0182] In some embodiments, for a compound or salt of Formula (IV), (TV-A), or (IV-C), e.g., for a compound or salt of Formula (IV), Ring B is a 5- to 10- membered spirocyclic heterocycle or C5-10 spirocyclic carbocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR30c, -SR30c, -N(R30c)2, -C(O)R30c, -C(O)N(R30c)2, -NO2, =0, and -CN; C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR30c, -SR30c, -N(R30c)2, -C(O)R30c, -C(O)N(R30c)2, -NO2, =0, and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30c, -SR30c, -N(R30c)2, -C(O)R30c, - C(O)N(R30c)2, -NO2, =0, -CN, C1-6 alkyl, and Ci-6 haloalkyl. In some embodiments, Ring B is a 5- to 10- membered spirocyclic heterocycle or C5-10 spirocyclic carbocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR30c, -N(R30c)2, =0, and -CN; C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR30c, -N(R30c)2, and -CN; and C3-6 carbocycle and 3- to 6-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30c, -N(R30c)2, =0, -CN, Ci-6 alkyl, and Ci-6 haloalkyl. In some embodiments Ring B is a 5- to 10- membered spirocyclic heterocycle or C5-10 spirocyclic carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30c, - N(R30c)2, =0, -CN, Ci-6 alkyl, and Ci-6 haloalkyl. In some embodiments, Ring B is a 5- to 10- membered spirocyclic heterocycle or C5-10 spirocyclic carbocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -OH, -N(H)2, =0, -CN; and C1-3 alkyl optionally substituted with one or more substituents independently selected from -F and -Cl. In some embodiments, Ring B is a 5- to 6- membered spirocyclic heterocycle or C5-6spirocyclic carbocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30c, -N(R30c)2, =0, -CN, Ci-6 alkyl, and Ci-6 haloalkyl. In some embodiments, Ring B is a 5- to 6- membered spirocyclic heterocycle or C5-6 spirocyclic carbocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -OH, -N(H)2, =0, -CN; and C1-3 alkyl optionally substituted with one or more substituents independently selected from -F and -Cl. In some embodiments, Ring B is a 5- to 6- membered spirocyclic heterocycle or C5-6 spirocyclic carbocycle. In some embodiments, Ring B is selected from a spirocyclic cyclopentyl, and a spirocyclic tetrahydro-2H-pyranyl each of which is optionally substituted with one or more substituents independently selected from -F, -OH, -N(H)2, =0, -CN; and C1-3 alkyl optionally substituted with one or more substituents independently selected from -F and -Cl. In some embodiments, Ring B is selected from.

[0183] In some embodiments, for a compound or salt of Formula (IV), (TV-A), or (IV-C), e.g., for a compound or salt of Formula (IV), R22is selected from:Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30b, -SR30b, - N(R30b)2, -C(O)R30b, -C(O)N(R30b)2, -N(R30b)C(O)R30b-C(O)OR30b, -OC(O)R30b, -NO2, =0, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R29b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30b, - SR30b, -N(R30b)2, -C(O)R30b, -C(O)N(R30b)2, -N(R30b)C(O)R30b-C(O)OR30b, -OC(O)R30b, - NO2, =0, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R29b.

[0184] In some embodiments R22is selected from Ci-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR30b, -SR30b, -N(R30b)2, -C(O)R30b, -NO2, =0, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R29b; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30b, -SR30b, -N(R30b)2, -NO2, =0, -CN; and Ci-6 alkyl optionally substituted with one or more R29b. In some embodiments R22is selected from: Ci-6 alkyl, optionally substituted with one or more substituents independently selected fromhalogen, -OR30b, -N(R30b)2, -CN, =0, C3-io carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R29b; and ...

Claims

1. CLAIMSWHAT IS CLAIMED IS:1 . A compound represented by Formula (I-C):or a salt thereof, wherein:X1, X2, X3, and X4are each independently selected from C(RX), N, and N+(O );Ring A is a 5- to 20-membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10h)2, - N(R10b)C(O)R10b-C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =0, =S, =N(R10b), and -CN;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, - N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b-C(O)OR10b, -OC(O)R10b, - N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -N02, =0, =S, =N(R10b), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more R9b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, - SR10b, -N(R10h)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b-N(R10b)C(O)N(R10b)2, - OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10h, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, - N02, =0, =S, =N(R10h), -CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, C3- 10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more R9b; each R1is independently selected from: hydrogen;halogen, -NO2, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, - N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, - N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, and -S(O)2R10a;Ci-6 alkyl, C4-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, - N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -C(O)OR10a, -OC(O)R10a, - N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -S(O)R10a, -S(O)2R10a, -NO2, =0, =S, =N(R10a), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9a; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, - SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, - OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, - N02, =0, =S, =N(R10a), -CN, C1-6 alkyl, C2.6 alkenyl, and C2.6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R9a;R3and R4are each independently selected from: hydrogen, halogen, -OR10c, -SR10c, -N(R10c)2, -N02, and -CN; andCi-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, -N(R10c)2, -N02, and -CN;R5and R6are each independently selected from: hydrogen, halogen, -OR10d, -SR10d, -N(R10d)2, -N02, and -CN;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, - N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d-C(O)OR10d, -OC(O)R10d, - N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -N02, =0, =S, =N(R10d), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9c; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, - SR10d, -N(R10d)2, -N02, and -CN; orR5together with R6form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more R9c;R8is selected from: hydrogen; andC1.4 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -NO2, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle are optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -NO2, and -CN; each R9a, R9b, and R9cis independently selected from: halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g- N(R10s)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, - S(O)R10g, -S(O)2R10g, -NO2, -O, =S, -N(RI Os), and -CN; andC1.3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, - N(R10g)2, -C(O)R10g, -C(O)N(R10S)2, -N(R10g)C(O)R10g-N(R10g)C(O)N(R10g)2, - OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, - NO2, =0, =S, =N(R10g), and -CN; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-s haloalkyl; and each R10a, R10b, R10c, R10d, R10f, and R10gis independently selected from: hydrogen;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-Ci-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-e haloalkyl; wherein when Ring A is a 5-membered heterocycle, then: R5and R6are each independently selected from: hydrogen, halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, and -CN;Ci-6 alkyl and C2-6 alkenyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, - N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d-C(O)OR10d, -OC(O)R10d, - N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -NO2, =0, =S, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9c; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, - SR10d, -N(R10d)2, -NO2, and -CN; orR5together with R6form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more R9c; and wherein when Ring A is a 6-membered heterocycle, and R8is optionally substituted Ci alkyl; then R8is selected from: Ci alkyl substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -NO2, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle are optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -NO2, and -CN.

2. The compound or salt of claim 1, wherein Ring A is a 5-, 6-, or 7-membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -NO2, =0, and -CN;Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -NO2, =0, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, - SR10b, -N(R10h)2, -C(O)R10b, -C(O)N(R10b)2, -NO2, =0, -CN, Ci-6alkyl, and Ci-6haloalkyl.

3. The compound or salt of claim 1 or claim 2, wherein Ring A is selected from:or a salt thereof, wherein:X1, X2, X3, and X4are each independently selected from C(RX) and N;Ring A is a 7- to 15-membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10h)2, - N(R10b)C(O)R10b-C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =0, =S, =N(R10b), and -CN;Ci-6 alkyl, C2-6 alkenyl, and C2-e alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, - N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b-C(O)OR10b, -OC(O)R10b, - N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -N02, =0, =S, =N(R10b), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, - SR10b, -N(R10h)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b-N(R10b)C(O)N(R10b)2, - OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10h, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, - N02, =0, =S, =N(R10h), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R9b; each R1is independently selected from:hydrogen; halogen, -NO2, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, - N(R10a)C(O)R10a-N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, - N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, and -S(O)2R10a;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, - N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -C(O)OR10a, -OC(O)R10a, - N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -S(O)R10a, -S(O)2R10a, -NO2, =0, =S, =N(R10a), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9a; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, - SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, - OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, - N02, =0, =S, =N(R10a), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R9a; each R3and R4are independently selected from: hydrogen, halogen, -OR10c, -SR10c, -N(R10c)2, -N02, and -CN; andCi-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, -N(R10c)2, -NO2, and -CN; each R5and R6are independently selected from: hydrogen, halogen, -OR10d, -SR10d, -N(R10d)2, -N02, and -CN;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, - N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d-C(O)OR10d, -OC(O)R10d, - N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -N02, =0, =S, =N(R10d), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9c; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, - SR10d, -N(R10d)2, -NO2, and -CN; orR5together with R6form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more R9c;R8is selected from: hydrogen; andCi-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -NO2, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle are optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -NO2, and -CN; each R9a, R9b, and R9care independently selected from: halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g- N(R10s)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, - S(O)R10g, -S(O)2R10g, -NO2, -O, =S, -N(RI Os), and -CN; andC1.3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, - N(R10g)2, -C(O)R10g, -C(O)N(R10S)2, -N(R10g)C(O)R10g-N(R10g)C(O)N(R10g)2, - OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, - NO2, =0, =S, =N(R10g), and -CN; each R10a, R10b, R10c, R10d, R10f, and R10gare independently selected from: hydrogen;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-Ci-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1.6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-s haloalkyl.

6. A compound represented by Formula (II):or a salt thereof, wherein:X1, X2, X3, and X4are each independently selected from C(RX) and N;Ring A is a 5- to 15-membered bridged or spirocyclic heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, - N(R10b)C(O)R10b-C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =0, =S, =N(R10b), and -CN;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, - N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b-C(O)OR10b, -OC(O)R10b, - N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -N02, =0, =S, =N(R10b), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, - SR10b, -N(R10h)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b-N(R10b)C(O)N(R10b)2, - OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10h, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, - N02, =0, =S, =N(R10h), -CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2.6 alkenyl, C2.6 alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more R9b; each R1is independently selected from: hydrogen; halogen, -N02, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, - N(R10a)C(O)R10a-N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, - N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, and -S(O)2R10a;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -C(O)OR10a, -OC(O)R10a, - N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -S(O)R10a, -S(O)2R10a, -N02, =0, =S, =N(R10a), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9a; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, - SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, - OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, - N02, =0, =S, =N(R10a), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R9a;R3and R4are each independently selected from: hydrogen, halogen, -OR10c, -SR10c, -N(R10c)2, -N02, and -CN; andCi-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, -N(R10c)2, -N02, and -CN;R5and R6are each independently selected from: hydrogen, halogen, -OR10d, -SR10d, -N(R10d)2, -N02, and -CN;Ci-6 alkyl, C2-6 alkenyl, and C2.6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, - N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d-C(O)OR10d, -OC(O)R10d, - N(R10d)C(O)N(R10d)2, -OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -S(O)R10d, -S(O)2R10d, -N02, =0, =S, =N(R10d), -CN, C3-io carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9c; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, - SR10d, -N(R10d)2, -N02, and -CN; orR5together with R6form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more R9c;R8is selected from: hydrogen; andCi-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -NO2, -CN, C3-10 carbocycle, and 3- to10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle are optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -NO2, and -CN; each R9a, R9b, and R9cis independently selected from: halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g- N(R10g)C(O)N(R10g)2, -OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, - S(O)R10g, -S(O)2R10g, -NO2, =0, =S, =N(R10g), and -CN; andCi-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, - N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, -N(R10g)C(O)R10g-N(R10g)C(O)N(R10g)2, - OC(O)N(R10g)2, -N(R10g)C(O)OR10g, -C(O)OR10g, -OC(O)R10g, -S(O)R10g, -S(O)2R10g, - NO2, =0, =S, =N(R10g), and -CN; and each R10a, R10b, R10c, R10d, R10f, and R10gis independently selected from: hydrogen;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - NO2, -NH2, -O, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(Ci-e alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-Ci-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-s haloalkyl.

8. The compound or salt of any one of claims 1 to 7, wherein the compound or salt is not:

9. The compound or salt of any one of claims 1 to 8, wherein X1, X2, X3, and X4are each independently selected from C(R1).

10. The compound or salt of any one of claims 1 to 9, wherein each R1is independently selected from: hydrogen, halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -NO2, and - CN;Ci-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10a, -N(R10a)2, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, - N(R10a)2, and -CN.

11. The compound or salt of any one of claims 1 to 10, wherein each R1is independently selected from: hydrogen, halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -NO2, -CN, Ci-6alkyl, and Ci-6 haloalkyl.

12. The compound or salt of any one of claims 1 to 11, wherein each R1is independently selected from hydrogen, -F, -Cl, -OH, -NH2, CN; and C1.3 alkyl optionally substituted with one or more substituents independently selected from -F and -Cl.

13. The compound or salt of any one of claims 1 to 12, wherein each R1is independently selected from hydrogen, and -F.

14. The compound or salt of claim 1 or any one of claims 6 to 13, wherein Ring A is a 5- to 15- membered bridged or spirocyclic heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10h)2, -NO2, =0, and -CN;Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N02, =0, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, - SR10b, -N(R10h)2, -C(O)R10b, -C(O)N(R10b)2, -N02, =0, -CN, Ci-6alkyl, and Ci-6haloalkyl.

15. The compound or salt of any one of claims 1 to 14 wherein Ring A is a 7 to 12-membered bridged or spirocyclic heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10h)2, -N02, O, and -CN;Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N02, =0, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, - SR10b, -N(R10h)2, -C(O)R10b, -C(O)N(R10b)2, -N02, =0, -CN, Ci-6alkyl, and Ci-6haloalkyl.

16. The compound or salt of any one of claims 1 to 15, wherein Ring A is a 7- to 12-membered bridged or spirocyclic heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OR10b, -N(R10b)2, =0, C(O)R10b, and -CN;Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10b, -N(R10b)2, -CN, and C3-10 carbocycle; andC3-6 carbocycle and 3- to 6-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, - N(R10b)2, =0, -CN, Ci-6 alkyl, Ci-6 haloalkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle.

17. The compound or salt of any one of claims 1 to 16, wherein Ring A is a 7- to 12-membered bridged or spirocyclic heterocycle optionally substituted with one or more substituents independently selected from halogen, -OR10b, -N(R10b)2, =0, C(O)R10b, -CN, and Ci-6 haloalkyl; Ci-6 alkyl optionally substituted with one or more substituents independently selected from C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10- membered heterocycle is optionally substituted with one or more R9b; and C3-6 carbocycle and 3- to 6-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen -OR10b, -N(R10b)2, =0, -CN, Ci-6 alkyl, Ci-6 haloalkyl, C3-io carbocycle, and 3- to 10-membered heterocycle.

18. The compound or salt of any one of claims 1 tol7 wherein Ring A is a 7- to 12-membered bridged or spirocyclic heterocycle optionally substituted with one or more substituents independently selected from:-F, -OH, -NH2, -C(O)Ph, =0, -CN; and C1.3 alkyl optionally substituted with one or more substituents independently selected from -F and -Cl; andCi-6 alkyl optionally substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more fluoro;C3-6 carbocycle and 3- to 6-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -CH3, isopropyl, -19. The compound or salt of any one of claims 1 to 18, wherein Ring A is selected from20. The compound or salt of any one of claims 1 to 19, wherein R3and R4are each independently selected from hydrogen, halogen, -OR10c, -N(R10c)2, and -CN; and Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10c, - N(R10C)2, and -CN.

21. The compound or salt of any one of claims 1 to 20, wherein R3and R4are each independently selected from hydrogen, halogen, Ci-6 alkyl, and Ci-6 haloalkyl.

22. The compound or salt of any one of claims 1 to21, wherein R3and R4are each hydrogen.

23. The compound or salt of any one of claims 1 to 22, wherein each R5and R6are independently selected from: hydrogen, halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, and -CN;Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -NO2, =0, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9c; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, - SR10d, -N(R10d)2, -N02, and -CN.

24. The compound or salt of any one of claims 1 to 23, wherein each R5and R6are independently selected from hydrogen, halogen, -OR10d, -CN, C1-4 alkyl optionally substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle, and C1-3 haloalkyl.

25. The compound or salt of any one of claims 1 to 24, wherein each R5and R6are hydrogen.

26. The compound or salt of any one of claims 1 to 25, whereinR5is selected from hydrogen, halogen, -OR10d, -SR10d, -N(R10d)2, -N02, and -CN; and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -R6is selected from Ci-6 alkyl optionally substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9c; and C4-6 alkyl optionally substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9C.

27. The compound or salt of claim 26, wherein R5is hydrogen; andR6is selected from C1-6 alkyl optionally substituted with one or more substituents independently selected from C3-6 carbocycle and 3- to 6- membered heterocycle, wherein the C3-6 carbocycle and 3- to 6-membered heterocycle are each optionally substituted with -F, -Cl, -OH, -NH2, -CN; and C1-3 alkyl optionally substituted with one or more substituents independently selected from -F and -Cl; and C4-6 alkyl optionally substituted with one or more substituents independently selected from C3-6 carbocycle and 3- to 6- membered heterocycle, wherein the C3-6 carbocycle and 3- to 6-membered heterocycle are each optionally substituted with -F, -Cl, -OH, -NH2, -CN; and C1-3 alkyl optionally substituted with one or more substituents independently selected from -F and -Cl.

28. The compound or salt of any one of claims 1 to 27, wherein R5is hydrogen; and R6is selected from C4-6 alkyl; and Ci alkyl substituted with C3-6 carbocycle or 3- to 6-membered heterocycle.

29. The compound or salt of any one of claims 1 to 28, wherein R5is hydrogen; and R6is selected30. The compound or salt of any one of claims 1 to 29, wherein R8is selected from hydrogen; and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10f, -SR10f, -N(R10f)2, -NO2, and -CN.

31. The compound or salt of any one of claims 1 to 30, wherein R8is selected from hydrogen, Ci substituted alkyl, C2-6 alkyl, and Ci-e haloalkyl.

32. The compound or salt of any one of claims 1 to 31, wherein R8is hydrogen.

33. The compound or salt of any one of claims 1 to 32, wherein each R9a, R9b, and R9care independently selected from: halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, - N(R10g)C(O)R10g-C(O)OR10g, -OC(O)R10g, -NO2, =0, and -CN;C1.3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10g, -SR10g, -N(R10g)2, -C(O)R10g, -C(O)N(R10g)2, - N(R10g)C(O)R10g-C(O)OR10g, -OC(O)R10g, -NO2, =0, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle.

34. The compound or salt of any one of claims 1 to 33, wherein each R9a, R9b, and R9care independently selected from halogen, -OR10g, -CN, C1-3 alkyl, and Ci-s haloalkyl.

35. The compound or salt of any one of claims 1 to 34, wherein each R10a, R10b, R10c, R10d, R10f, and R10gis independently selected from hydrogen, C1-6 alkyl, C3-10 carbocycle, and 3- to 10- membered heterocycle, wherein the Ci-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, and -NH2.

36. The compound or salt of any one of claims 1 to 35, wherein each R10a, R10b, R10c, R10d, R10f, and R10gis independently selected from hydrogen, C1-3 alkyl, and C1-3 haloalkyl.

37. A compound represented by Formula (III-C):or a salt thereof, wherein:X11, X12, X13, and X14are each independently selected from C(R" ), and N; each R11is independently selected from: hydrogen; halogen, -NO2, -CN, -OR20a, -SR20a, -N(R20a)2, -C(O)R20a, -C(O)N(R20a)2, - N(R20a)C(O)R20a, -N(R20a)C(O)N(R20a)2, -OC(O)N(R20a)2, - N(R20a)C(O)OR20a, -C(O)OR20a, -OC(O)R20a, -S(O)R20a, and -S(O)2R20a;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20a, -SR20a, - N(R20a)2, -C(O)R20a, -C(O)N(R20a)2, -N(R20a)C(O)R20a, -C(O)OR20a, -OC(O)R20a, - N(R20a)C(O)N(R20a)2, -OC(O)N(R20a)2, -N(R20a)C(O)OR20a, -S(O)R20a, -S(O)2R20a, -NO2, =0, =S, =N(R20a), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19a; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20a, - SR20a, -N(R20a)2, -C(O)R20a, -C(O)N(R20a)2, -N(R20a)C(O)R20a, -N(R20a)C(O)N(R20a)2, - OC(O)N(R20a)2, -N(R20a)C(O)OR20a, -C(O)OR20a, -OC(O)R20a, -S(O)R20a, -S(O)2R20a, - N02, =0, =S, =N(R20a), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R19a;R12is selected from:C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20b, -SR20b, - N(R20b)2, -C(O)R20b, -C(O)N(R20b)2, -N(R20b)C(O)R20b-OC(O)R20b, - N(R20b)C(O)N(R20b)2, -OC(O)N(R20b)2, -N(R20b)C(O)OR20b, -S(O)R20b, -S(O)2R20b, -N02, =S, =N(R20b), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3- 10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19b; andCa-io carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20b, - SR20b, -N(R20b)2, -C(O)R20b, -C(O)N(R20b)2, -N(R20b)C(O)R20b-N(R20b)C(O)N(R20b)2, - OC(O)N(R20b)2, -N(R20b)C(O)OR20b, -C(O)OR20h, -OC(O)R20b, -S(O)R20b, -S(O)2R20b, - NO2, =0, =S, =N(R20h), -CN, Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein Ci-g alkyl, C2.6 alkenyl, and C2.6 alkynyl are each optionally substituted with one or more R19b; andR13and R14are each independently selected from: hydrogen, halogen, -OR2011, -SR20c, -N(R20c)2, -N02, and -CN; andCi-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR20c, -SR20c, -N(R20c)2, -N02, and -CN;R15is independently selected from: hydrogen, halogen, -OR20d, -SR20d, -N(R20d)2, -N02, and -CN;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20d, -SR20d, - N(R20d)2, -C(O)R20d, -C(O)N(R20d)2, -N(R20d)C(O)R20d-C(O)OR20d, -OC(O)R20d, - N(R20d)C(O)N(R20d)2, -OC(O)N(R20d)2, -N(R20d)C(O)OR20d, -S(O)R20d, -S(O)2R20d, -N02, O, =S, =N(R20d), and -CN; orR15together with R16form a 3 - to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more R19c;R16is independently selected from:Ci-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is substituted with one or more substituents independently selected from: halogen, -OR20d, -SR20d, - N(R20d)2, -C(O)R20d, -C(O)N(R20d)2, -N(R20d)C(O)R20d-C(O)OR20d, -OC(O)R20d, - N(R20d)C(O)N(R20d)2, -OC(O)N(R20d)2, -N(R20d)C(O)OR20d, -S(O)R20d, -S(O)2R20d, -NO2, =0, =S, =N(R20d), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R19c; andC4-6 alkyl, C4-6 alkenyl, and C4-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20d, -SR20d, - N(R20d)2, -C(O)R20d, -C(O)N(R20d)2, -N(R20d)C(O)R20d-C(O)OR20d, -OC(O)R20d, - N(R20d)C(O)N(R20d)2, -OC(O)N(R20d)2, -N(R20d)C(O)OR20d, -S(O)R20d, -S(O)2R20d, -NO2, =0, =S, =N(R20d), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein theC3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R19c; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20d, - SR20d, -N(R20d)2, -C(O)R20d, -C(O)N(R20d)2, -N(R20d)C(O)R20d-C(O)OR20d, -OC(O)R20d, - N(R20d)C(O)N(R20d)2, -OC(O)N(R20d)2, -N(R20d)C(O)OR20d, -S(O)R20d, -S(O)2R20d, -NO2, =0, =S, =N(R20d), -CN, and C1-6 alkyl, wherein each Ci-6 alkyl is optionally substituted with one or more substituents independently selected from R19c; orR15together with R16form a 3 - to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R19c;R17is selected from: hydrogen and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR20e, -SR20e, -N(R20e)2, -NO2, and -CN;R18is selected from: hydrogen; andCi-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR20f, -SR20f, -N(R20f)2, -NO2, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle are optionally substituted with one or more substituents independently selected from halogen, -OR20f, -SR20f, -N(R20f)2, -NO2, and -CN; each R19a, R19b, R19c, are independently selected from: halogen, -OR20g, -SR20g, -N(R20g)2, -C(O)R20g, -C(O)N(R20g)2, -N(R20g)C(O)R20g- N(R20g)C(O)N(R20g)2, -OC(O)N(R20g)2, -N(R20g)C(O)OR20g, -C(O)OR20g, -OC(O)R20g, - S(O)R20g, -S(O)2R20g, -NO2, =0, =S, =N(R20g), and -CN; andCi-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20g, -SR20g, - N(R20g)2, -C(O)R20g, -C(O)N(R20g)2, -N(R20g)C(O)R20g-N(R20g)C(O)N(R20g)2, - OC(O)N(R20g)2, -N(R20g)C(O)OR20g, -C(O)OR20g, -OC(O)R20g, -S(O)R20g, -S(O)2R20g, - NO2, =0, =S, =N(R20g), and -CN; each R20a, R20b, R20c, R20dR20e, R20f, and R20gis independently selected from: hydrogen;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -N02, -NH2, =0, =S, -0-C1-6 alkyl, -S-Ci-6alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-Ci-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2.6 alkenyl, C2.6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-e haloalkyl; andR20his independently selected from: hydrogen;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - N02, -NH2, =0, =S, -O-C1.6 alkyl, -S-Ci-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-Ci-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-s haloalkyl.

38. A compound represented by Formula (III):or a salt thereof, wherein:X11, X12, X13, and X14are each independently selected from C(R"), and N; each R11is independently selected from: hydrogen; halogen, -N02, -CN, -OR20a, -SR20a, -N(R20a)2, -C(O)R20a, -C(O)N(R20a)2, - N(R20a)C(O)R20a, -N(R20a)C(O)N(R20a)2, -OC(O)N(R20a)2, -N(R20a)C(O)OR20a, -C(O)OR20a, -OC(O)R20a, -S(O)R20a, and -S(O)2R20a;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20a, -SR20a, - N(R20a)2, -C(O)R20a, -C(O)N(R20a)2, -N(R20a)C(O)R20a, -C(O)OR20a, -OC(O)R20a, -N(R20a)C(O)N(R20a)2, -OC(O)N(R20a)2, -N(R20a)C(O)OR20a, -S(O)R20a, -S(O)2R20a, -N02, =0, =S, =N(R20a), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19a; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20a, -yl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R19a;R12is selected from:Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20b, -SR20b, - N(R20b)2, -C(O)R20b, -C(O)N(R20b)2, -N(R20b)C(O)R20b. -C(O)OR20b, -OC(O)R20b, - N(R20b)C(O)N(R20b)2, -OC(O)N(R20b)2, -N(R20b)C(O)OR20b, -S(O)R20b, -S(O)2R20b, -N02, =S, =N(R20b), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3- 10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20b, - SR20b, -N(R20h)2, -C(O)R20b, -C(O)N(R20b)2, -N(R20b)C(O)R20b-N(R20b)C(O)N(R20b)2, - OC(O)N(R20b)2, -N(R20b)C(O)OR20b, -C(O)OR20h, -OC(O)R20b, -S(O)R20b, -S(O)2R20b, - NO2, =0, =S, =N(R20h), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R19b; and R13and R14are each independently selected from: hydrogen, halogen, -OR2011, -SR20c, -N(R20c)2, -NO2, and -CN; andCi-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR20c, -SR20c, -N(R20c)2, -NO2, and -CN;R15is independently selected from: hydrogen, halogen, -OR20d, -SR20d, -N(R20d)2, -NO2, and -CN;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20d, -SR20d, - N(R20d)2, -C(O)R20d, -C(O)N(R20d)2, -N(R20d)C(O)R20d-C(O)OR20d, -OC(O)R20d, -N(R20d)C(O)N(R20d)2, -OC(O)N(R20d)2, -N(R20d)C(O)OR20d, -S(O)R20d, -S(O)2R20d, -N02, =0, =S, =N(R20d), and -CN; orR15together with R16form a 3 - to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more R19c;R16is independently selected from:Ci-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19c; andC4-6 alkyl, C4-6 alkenyl, and C4-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10- membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19c; orR15together with R16form a 3 - to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more R19c;R17is selected from: hydrogen and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR20e, -SR20e, -N(R20e)2, -NO2, and -CN;R18is selected from: hydrogen; andCi-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR20f, -SR20f, -N(R20f)2, -NO2, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle are optionally substituted with one or more substituents independently selected from halogen, -OR20f, -SR20f, -N(R20f)2, -NO2, and -CN; each R19a, R19b, R19c, are independently selected from: halogen, -OR20g, -SR20g, -N(R20g)2, -C(O)R20g, -C(O)N(R20g)2, -N(R20g)C(O)R20g- N(R20g)C(O)N(R20g)2, -OC(O)N(R20g)2, -N(R20g)C(O)OR20g, -C(O)OR20g, -OC(O)R20g, - S(O)R20g, -S(O)2R20g, -NO2, =0, =S, =N(R20g), and -CN; andCi-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20g, -SR20g, - N(R20g)2, -C(O)R20g, -C(O)N(R20g)2, -N(R20g)C(O)R20g-N(R20g)C(O)N(R20g)2, -OC(O)N(R20g)2, -N(R20g)C(O)OR20g, -C(O)OR20g, -OC(O)R20g, -S(O)R20g, -S(O)2R20g- N02, =0, =S, =N(R20g), and -CN; each R20a, R20b, R20c, R20dR20e, R20f, and R20gis independently selected from: hydrogen;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - N02, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, ~0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-e haloalkyl; andR20his independently selected from:Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - NO2, -NH2, ~0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-Ci-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-s haloalkyl.

39. The compound or salt of claim 37 or 38, wherein the compound is not:thereof.

40. The compound or salt of any one of claims 37 to 39, wherein X11, X12, X13, and X14are each independently selected from C(R1).

41. The compound or salt of any one of claims 37 to 40, wherein each R11is independently selected from: hydrogen, halogen, -OR20a, -SR20a, -N(R20a)2, -C(O)R20a, -C(O)N(R20a)2, -NO2, and - CN;Ci-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR20a, -N(R20a)2, and -CN; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20a, - N(R20a)2, and -CN.

42. The compound or salt of any one of claims 37 to 41, wherein each R11is independently selected from hydrogen, -Cl and -CN.

43. The compound or salt of any one of claims 37 to 42, wherein R12is selected from:C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR20b, -SR20b, -N(R20b)2, -NO2, -CN, =0, C3-10 carbocycle, and 3- to 10- membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR20b, - SR20b, -N(R20b)2, =0, -NO2, -CN, and Ci-6 alkyl, wherein each C1-6 alkyl is optionally substituted with one or more R19b.

44. The compound or salt of any one of claims 37 to 43, wherein R12is selected from C2alkyl, optionally substituted with one or more substituents independently selected from C3-6 carbocycle and 3- to 6-membered heterocycle, wherein the C3-6 carbocycle and 3- to 6- membered heterocycle are each optionally substituted with one or more substituents independently selected from -F, -Cl, -OH, -NH2, and -CN.The compound or salt of any one of claims 37 to 44, wherein R12is selected from46. The compound or salt of any one of claims 37 to 45, wherein R13and R14are each independently selected from hydrogen, halogen, Ci-6 alkyl, and Ci-6 haloalkyl.

47. The compound or salt of any one of claims 37 to 46, wherein R13and R14are each hydrogen.

48. The compound or salt of any one of claims 37 to 47, wherein R15is independently selected from: hydrogen, halogen, -OR20d, -SR20d, -N(R20d)2, -NCh, and -CN;C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR20d, -SR20d, -N(R20d)2, -C(O)R20d, -C(O)N(R20d)2, -NO2, =0, and -CN; andR16is independently selected from:Ci-3 alkyl substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19c; andC4-6 alkyl optionally substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19c.

49. The compound or salt of any one of claims 37 to 48, wherein R15is selected from: hydrogen, halogen, -OR20d, -SR20d, -N(R20d)2, -NO2, and -CN; and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR20d, -SR20d, -N(R20d)2, -N02, =0, and -CN; andR16is selected from:Ci-3 alkyl substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19c; andC4-6 alkyl optionally substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R19c.

50. The compound or salt of any one of claims 37 to 49, whereinR15is hydrogen; andR16is selected fromCi-3 alkyl substituted with one or more substituents independently selected from C3-6 carbocycle and 3- to 10- membered heterocycle; andC4-6 alkyl optionally substituted with one or more substituents independently selected from C3-6 carbocycle and 3- to 6-membered heterocycle.

51. The compound or salt of any one of claims 37 to 50, wherein R15is hydrogen; and R16is52. The compound or salt of any one of claims 37 to 51, wherein R17is hydrogen.

53. The compound or salt of any one of claims 37 to 52, wherein R18is hydrogen.

54. A compound represented by Formula (IV-C):or a salt thereof, wherein:X21, X22, X23, and X24are each independently selected from C(R21) and N;Ring B is a 3 - to 10- membered spirocyclic heterocycle or C3-10 spirocyclic carbocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR30c, -SR30c, -N(R30c)2, -C(O)R30c, -C(O)N(R30c)2, - N(R30C)C(O)R30C, -C(O)OR30C, -OC(O)R30C, -N(R30C)C(O)N(R30C)2, -OC(O)N(R30C)2, - N(R30C)C(O)OR30C, -S(O)R30C, -S(O)2R30C, -NO2, =0, =S, =N(R30C), and -CN;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30c, -SR30c, - N(R30C)2, -C(O)R30C, -C(O)N(R30C)2, -N(R30C)C(O)R30C, -C(O)OR30C, -OC(O)R30C, - N(R30c)C(O)N(R30c)2, -OC(O)N(R30C)2, -N(R30C)C(O)OR30C, -S(O)R30C, -S(O)2R30C, -NO2, =0, =S, =N(R30c), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R29c; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30c, - SR30c, -N(R30C)2, -C(O)R30C, -C(O)N(R30C)2, -N(R30C)C(O)R30C, -N(R30C)C(O)N(R30C)2, - OC(O)N(R30c)2, -N(R30C)C(O)OR30C, -C(O)OR30C, -OC(O)R30C, -S(O)R30C, -S(O)2R30C, - NO2, =0, =S, =N(R30C), -CN, CI-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein Ci-6 alkyl, C2.6 alkenyl, and C2.6 alkynyl are each optionally substituted with one or more R29c; each R21is independently selected from: hydrogen; halogen, -N02, -CN, -OR30a, -SR30a, -N(R30a)2, -C(O)R30a, -C(O)N(R30a)2, - N(R30a)C(O)R30a-N(R30a)C(O)N(R30a)2, -OC(O)N(R30a)2, - N(R30a)C(O)OR30a, -C(O)OR30a, -OC(O)R30a, -S(O)R30a, and -S(O)2R30a;Ci-6 alkyl, C2.6 alkenyl, and C2.6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30a, -SR30a, - N(R30a)2, -C(O)R30a, -C(O)N(R30a)2, -N(R30a)C(O)R30a, -C(O)OR30a, -OC(O)R30a, - N(R30a)C(O)N(R30a)2, -OC(O)N(R30a)2, -N(R30a)C(O)OR30a, -S(O)R30a, -S(O)2R30a, -N02, =0, =S, =N(R30a), -CN, C3-io carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R29a; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30a, - SR30a, -N(R30a)2, -C(O)R30a, -C(O)N(R30a)2, -N(R30a)C(O)R30a, -N(R30a)C(O)N(R30a)2, - OC(O)N(R30a)2, -N(R30a)C(O)OR30a, -C(O)OR30a, -OC(O)R30a, -S(O)R30a, -S(O)2R30a, - N02, =0, =S, =N(R30a), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R29a;R22is selected from:Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30b, -SR30b, - N(R30b)2, -C(O)R30b, -C(O)N(R30b)2, -N(R30b)C(O)R30b-C(O)OR30b, -OC(O)R30b, - N(R30b)C(O)N(R30b)2, -OC(O)N(R30b)2, -N(R30b)C(O)OR30b, -S(O)R30b, -S(O)2R30b, -N02, =0, =S, =N(R30b), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R29b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30b, -yl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R29b; or R22together with R27form a 3- to 20-membered heterocycle optionally substituted with one or more substituents independently selected from:Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR30b, -SR30b, -N(R30b)2, -C(O)R30b, -C(O)N(R30b)2, -N(R30b)C(O)R30b-C(O)OR30b, - OC(O)R30b, -N(R30b)C(O)N(R30b)2, -OC(O)N(R30b)2, -N(R30b)C(O)OR30b, -S(O)R30b, - S(O)2R30b, -N02, 0, =S, N(R30b), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R29b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30b, -SR30b, -N(R30h)2, -C(O)R30b, -C(O)N(R30b)2, -N(R30b)C(O)R30b- N(R30b)C(O)N(R30b)2, -OC(O)N(R30b)2, -N(R30b)C(O)OR30b, -C(O)OR30b, -OC(O)R30b, -S(O)R30b, -S(O)2R30b, -N02, =0, =S, =N(R30b), -CN, Ci-6alkyl, C2.6alkenyl, and C2.6alkynyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more R29b; each R25and R26are independently selected from: hydrogen, halogen, -OR30d, -SR30d, -N(R30d)2, -N02, and -CN;Ci-6 alkyl, C2-6 alkenyl, and C2.6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30d, -SR30d, - N(R30d)2, -C(O)R30d, -C(O)N(R30d)2, -N(R30d)C(O)R30d-C(O)OR30d, -OC(O)R30d, - N(R30d)C(O)N(R30d)2, -OC(O)N(R30d)2, -N(R30d)C(O)OR30d, -S(O)R30d, -S(O)2R30d, -N02, =0, =S, =N(R30d), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R29c; andCa-io carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30d, - SR30d, -N(R30d)2, -NO2, and -CN; orR25together with R26form a 3 - to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more R29c,R27is selected from: hydrogen and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR30e, -SR30e, -N(R30e)2, -NO2, and -CN;R28is selected from: hydrogen; andCi-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR30f, -SR30f, -N(R30f)2, -NO2, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle are optionally substituted with one or more substituents independently selected from halogen, -OR30f, -SR30f, -N(R30f)2, -NO2, and -CN; each R29a, R29b, and R29cis independently selected from: halogen, -OR30g, -SR30g, -N(R30g)2, -C(O)R30g, -C(O)N(R30g)2, -N(R30g)C(O)R30g- N(R30g)C(O)N(R30g)2, -OC(O)N(R30g)2, -N(R30g)C(O)OR30g, -C(O)OR30g, -OC(O)R30g, - S(O)R30g, -S(O)2R30g, -NO2, =0, =S, =N(R30g), and -CN; andC1.3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30g, -SR30g, - N(R30g)2, -C(O)R30g, -C(O)N(R30g)2, -N(R30g)C(O)R30g-N(R30g)C(O)N(R30g)2, - OC(O)N(R30g)2, -N(R30g)C(O)OR30g, -C(O)OR30g, -OC(O)R30g, -S(O)R30g, -S(O)2R30g, - NO2, =0, =S, =N(R30g), and -CN; and each R30a, R30b, R30c, R30d, R30e, R30f, and R30gis independently selected from: hydrogen;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-Ci-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1.6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-e haloalkyl.

55. A compound represented by Formula (IV):or a salt thereof, wherein:X21, X22, X23, and X24are each independently selected from C(R21) and N;Ring B is a 5- to 10- membered spirocyclic heterocycle or C5-10 spirocyclic carbocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR30c, -SR30c, -N(R30c)2, -C(O)R30c, -C(O)N(R30c)2, - N(R30C)C(O)R30C, -C(O)OR30C, -OC(O)R30C, -N(R30C)C(O)N(R30C)2, -OC(O)N(R30C)2, - N(R30c)C(O)OR30c, -S(O)R30C, -S(O)2R30C, -NO2, =0, =S, =N(R30C), and -CN;Ci-6 alkyl, C2-6 alkenyl, and C2.6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30c, -SR30c, - N(R30c)2, -C(O)R30C, -C(O)N(R30C)2, -N(R30C)C(O)R30C, -C(O)OR30C, -OC(O)R30C, - N(R30c)C(O)N(R30c)2, -OC(O)N(R30C)2, -N(R30C)C(O)OR30C, -S(O)R30C, -S(O)2R30C, -NO2, =0, =S, =N(R30C), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R29c; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30c, - SR30C, -N(R30C)2, -C(O)R30C, -C(O)N(R30C)2, -N(R30C)C(O)R30C, -N(R30C)C(O)N(R30C)2, - OC(O)N(R30C)2, -N(R30C)C(O)OR30C, -C(O)OR30C, -OC(O)R30C, -S(O)R30C, -S(O)2R30C, - NO2, =0, =S, =N(R30C), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R29c; each R21is independently selected from: hydrogen; halogen, -NO2, -CN, -OR30a, -SR30a, -N(R30a)2, -C(O)R30a, -C(O)N(R30a)2, - N(R30a)C(O)R30a-N(R30a)C(O)N(R30a)2, -OC(O)N(R30a)2, - N(R30a)C(O)OR30a, -C(O)OR30a, -OC(O)R30a, -S(O)R30a, and -S(O)2R30a;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30a, -SR30a, - N(R30a)2, -C(O)R30a, -C(O)N(R30a)2, -N(R30a)C(O)R30a, -C(O)OR30a, -OC(O)R30a, - N(R30a)C(O)N(R30a)2, -OC(O)N(R30a)2, -N(R30a)C(O)OR30a, -S(O)R30a, -S(O)2R30a, -NO2, =0, =S, =N(R30a), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R29a; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30a, - SR30a, -N(R30a)2, -C(O)R30a, -C(O)N(R30a)2, -N(R30a)C(O)R30a, -N(R30a)C(O)N(R30a)2, - OC(O)N(R30a)2, -N(R30a)C(O)OR30a, -C(O)OR30a, -OC(O)R30a, -S(O)R30a, -S(O)2R30a, - NO2, =0, =S, =N(R30a), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R29a;R22is selected from:Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30b, -SR30b, - N(R30b)2, -C(O)R30b, -C(O)N(R30b)2, -N(R30b)C(O)R30b-C(O)OR30b, -OC(O)R30b, - N(R30b)C(O)N(R30b)2, -OC(O)N(R30b)2, -N(R30b)C(O)OR30b, -S(O)R30b, -S(O)2R30b, -NO2, =0, =S, =N(R30b), -CN, C3-io carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R29b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30b, - SR30b, -N(R30h)2, -C(O)R30b, -C(O)N(R30b)2, -N(R30b)C(O)R30b-N(R30b)C(O)N(R30b)2, - OC(O)N(R30b)2, -N(R30b)C(O)OR30b, -C(O)OR30h, -OC(O)R30b, -S(O)R30b, -S(O)2R30b, - NO2, =0, =S, =N(R30h), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R29b; each R25and R26are independently selected from: hydrogen, halogen, -OR30d, -SR30d, -N(R30d)2, -NO2, and -CN;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30d, -SR30d, - N(R30d)2, -C(O)R30d, -C(O)N(R30d)2, -N(R30d)C(O)R30d-C(O)OR30d, -OC(O)R30d, - N(R30d)C(O)N(R30d)2, -OC(O)N(R30d)2, -N(R30d)C(O)OR30d, -S(O)R30d, -S(O)2R30d, -NO2, =0, =S, =N(R30d), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein theC3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R29c; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30d, - SR30d, -N(R30d)2, -NO2, and -CN; orR25together with R26form a 3 - to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more R29c;R27is selected from: hydrogen and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR30e, -SR30e, -N(R30e)2, -NO2, and -CN;R28is selected from: hydrogen; andCi-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR30f, -SR30f, -N(R30f)2, -NO2, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle are optionally substituted with one or more substituents independently selected from halogen, -OR30f, -SR30f, -N(R30f)2, -NO2, and -CN; each R29a, R29b, and R29care independently selected from: halogen, -OR30g, -SR30g, -N(R30g)2, -C(O)R30g, -C(O)N(R30g)2, -N(R30g)C(O)R30g- N(R30g)C(O)N(R30g)2, -OC(O)N(R30g)2, -N(R30g)C(O)OR30g, -C(O)OR30g, -OC(O)R30g, - S(O)R30g, -S(O)2R30g, -NO2, =0, =S, =N(R30g), and -CN; andCi-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30g, -SR30g, - N(R30g)2, -C(O)R30g, -C(O)N(R30g)2, -N(R30g)C(O)R30g-N(R30g)C(O)N(R30g)2, - OC(O)N(R30g)2, -N(R30g)C(O)OR30g, -C(O)OR30g, -OC(O)R30g, -S(O)R30g, -S(O)2R30g, - NO2, =0, =S, =N(R30g), and -CN; and each R30a, R30b, R30c, R30d, R30e, R30f, and R30gare independently selected from: hydrogen;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1.6 alkyl, -S-C1.6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-e haloalkyl.

56. The compound or salt of claim 54 or 55, wherein the compound or salt is not a compound of List 1, or a salt of any thereof.

57. The compound or salt of any one of claims 54 to 56, wherein X3and X4are C(H).

58. The compound or salt of any one of claims 54 to 57, wherein each R21is independently selected from hydrogen, and -F.

59. The compound or salt of any one of claims 54 to 58, wherein Ring B is a 5- to 6- membered spirocyclic heterocycle or spirocyclic C5-6 carbocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -OH, -N(H)2, =0, -CN; and C1.3 alkyl optionally substituted with one or more substituents independently selected from -F and - Cl.

60. The compound or salt of any one of claims 54 to 59, wherein Ring B is selected from61. The compound or salt of any one of claims 54 to 60, wherein R22is selected from C2 alkyl, optionally substituted with one or more substituents independently selected from C3-6 carbocycle and 3- to 6-membered heterocycle, wherein the C3-6 carbocycle and 3- to 6- membered heterocycle are each optionally substituted with one or more substituents independently selected from -F, -Cl, -OH, -NH2, and -CN.

62. The compound or salt of any one of claims 54 to 61, wherein R22is selected from63. The compound or salt of any one of claims 54 to 62, wherein each R25and R26are independently selected from: hydrogen, halogen, -OR30d, -SR30d, -N(R30d)2, -NO2, and -CN;Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR30d, -SR30d, -N(R30d)2, -C(O)R30d, -C(O)N(R30d)2, -N02,=0, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R29c; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR30d, - SR30d, -N(R30d)2, -NO2, and -CN.

64. The compound or salt of any one of claims 54 to 63, wherein each R25and R26are independently selected from hydrogen, halogen, -OR30d, -CN, , and C1.3 haloalkyl; and C1-3 alkyl optionally substituted with one substituent selected from C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: hydrogen, halogen, -OR30d, -CN, C1.3 alkyl.

65. The compound or salt of any one of claims 54 to 64, wherein each R25and R26are hydrogen.

66. The compound or salt of claims 54 to 64, wherein R25is hydrogen; and R26is selected from C1-6 alkyl optionally substituted with one or more substituents independently selected from -OH and phenyl.

67. The compound or salt of any one of claims 54 to 64, wherein R25is hydrogen; and R26is selected from68. The compound or salt of any one of claims 54 to 64, wherein R25is hydrogen; and R26is selected from69. The compound or salt of any one of claims 54 to 68, wherein R27is hydrogen.

70. The compound or salt of any one of claims 54 to 69, wherein R28is hydrogen.

71. The compound or salt of any one of claims 54, 56-60, 63-68, or 70, wherein R22together with R27form a 3- to 20-membered heterocycle that is optionally substituted.

72. The compound or salt of any one of claims 54, 56-60, 63-68, or 70 to 71, wherein R22together with R27form a 3- to 20-membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(Ci-6alkyl), -NH2, -NH(CI-6alkyl), -N(CI-6alkyl)2, -SH, - S(Ci-6 alkyl), =0, -CN, Ci-6 alkyl, and Ci-6 haloalkyl;C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(Ci-6alkyl), -NH2, -NH(CI-6alkyl), -N(CI-6alkyl)2, -SH, -S(Ci-6alkyl), =0, -CN, Ci-6 alkyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C1-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(Ci-6alkyl), -NH2, -NH(CI-6alkyl), -N(CI-6alkyl)2, -SH, -S(Ci-6alkyl), =0, -CN, and C1-6 alkyl.

73. The compound or salt of any one of claims 54, 56-60, 63-68, or 70 to 72, wherein R22together with R27form a heterocycle selected fromthat is optionally substituted.

74. The compound or salt of any one of claims 1 to 30, wherein the compound is selected from: compounds: Al, A2, A3, A4, A5, A6, A7, A8, A9, A10, Al l, A12, A13, A14, A15, A16, A17, A18, A19, A20, A21, A22, A23, A24, A25, A26, A27, A28, A29, A30, A31, A32, A33, AA34, AA35, AA36, AA37, AA38, AA39, AA40, AA41, AA42, AA43, AA44, AA45, AA46, AA47, AA48, AA49, AA50, AA51, AA52, AA53, AA54, AA55, AA56, AA57, AA58, AA59, AA60, AA61, AA62, AA63, AA64, AA65, AA66, AA67, AA68, AA69, AA70, AA71, AA72, AA73, AA74, AA75, AA76, AA77, AA78, AA79, AA80, AA81, AA82, AA83, AA84, AA85, AA86, AA87, AA88, AA89, AA90, AA91, AA92, AA93, AA94, AA95, AA96, AA97, AA98, AA99, AA100, AA101, AA102, AA103, AA104, AA105, AA106, AA107, AA108, AA109, AA110, AA111, AA112, AA113, AA114, AA115, AA116, AA117, AA118, AA119, AA120, AA121, AA122, AA123, AA124, AA125, AA126, AA127, AA128, AA129, AA130, AA131, AA132, AA133, AA134, AA135, AA136, AA137, AA138, AA139, AA140, AA141, AA142, AA143, AA144, AA145, AA146, AA147, AA148, AA149, AA150, AA151, AA152, AA153, AA154, AA155, AA156, AA157, AA158, AA159, AA160, AA161, AA162, AA163, AA164, AA165, AA166, AA167, AA168, AA169, AA170, AA171, AA172, AA173, AA174, AA175, AA176, AA177, AA178, AA179, AA180, AA181, AA182, AA183, and AA184, or a salt of any one thereof.

75. The compound or salt of claim 1 or claim 60, wherein the compound is selected from: AAA185, AAA186, AAA187, AAA188, AAA189, AAA190, AAA191, AAA192, AAA193, AAA194, AAA195, AAA196, AAA197, AAA198, AAA199, AAA200, AAA201, AAA202, AAA203, AAA204, AAA205, AAA206, AAA207, AAA208, AAA209, AAA210, AAA211, AAA212, AAA213, AAA214, AAA215, AAA216, AAA217, AAA218, AAA219, AAA220, AAA221, AAA222, AAA223, AAA224, AAA225, AAA226, AAA227, AAA228, AAA229, AAA230, AAA231, AAA232, AAA233, AAA234, AAA235, AAA236, AAA237, AAA238, AAA239, AAA240, AAA241, AAA242, AAA243, AAA244, AAA245, AAA246, AAA247, AAA248, AAA249, AAA250, AAA251, AAA252, AAA253, AAA254, AAA255, AAA256,AAA257, AAA258, AAA259, AAA260, AAA261, AAA262, AAA263, AAA264, AAA265, AAA266, AAA267, AAA268, AAA269, AAA270, AAA271, AAA272, AAA273, AAA274, AAA275, AAA276, AAA277, AAA278, AAA279, AAA280, AAA281, AAA282, AAA283, AAA284, AAA285, AAA286, AAA287, AAA288, AAA289, AAA290, AAA291, AAA292, AAA293, AAA294, AAA295, AAA296, AAA297, AAA298, AAA299, AAA300, AAA301, AAA302, AAA303, AAA304, AAA305, AAA306, AAA307, AAA308, AAA309, AAA310, AAA311, AAA312, AAA313, AAA314, AAA315, AAA316, AAA317, AAA318, AAA319, AAA320, AAA321, AAA322, AAA323, AAA324, AAA325, AAA326, AAA327, AAA328, AAA329, AAA330, AAA331, AAA332, AAA333, AAA334, AAA335, AAA336, AAA337, AAA338, AAA339, AAA340, AAA341, AAA342, AAA343, AAA344, AAA345, AAA346, AAA347, AAA348, AAA349, AAA350, AAA351, AAA352, AAA353, AAA354, AAA355, or a salt of any one thereof.

76. The compound or salt of claim 37 or 38, wherein the compound of Formula (III) is selected from:Bl, B2, B3, B4, B5, B6, B7, B8, B9, BIO, and BB11, or a salt of any one thereof.

77. The compound or salt of claim 55, wherein the compound of Formula (IV) is selected from: compounds: Cl, C2, C3, C4, C5, C6, C7, CC8, CC9, CC10, and CC11, or a salt of any one thereof.

78. The compound or salt of claim 55, wherein the compound is selected from: CC12, CC13, CC14, CC15, CC16, CC17, or a salt of any one thereof.

79. A compound selected from: compounds: Al, A2, A3, A4, A5, A6, A7, A8, A9, A10, Al l, A12, Al 3, A14, Al 5, Al 6, Al 7, Al 8, Al 9, A20, A21, A22, A23, A24, A25, A26, A27, A28, A29, A30, A31, A32, A33, AA34, AA35, AA36, AA37, AA38, AA39, AA40, AA41, AA42, AA43, AA44, AA45, AA46, AA47, AA48, AA49, AA50, AA51, AA52, AA53, AA54, AA55, AA56, AA57, AA58, AA59, AA60, AA61, AA62, AA63, AA64, AA65, AA66, AA67, AA68, AA69, AA70, AA71, AA72, AA73, AA74, AA75, AA76, AA77, AA78, AA79, AA80, AA81, AA82, AA83, AA84, AA85, AA86, AA87, AA88, AA89, AA90, AA91, AA92, AA93, AA94, AA95, AA96, AA97, AA98, AA99, AA100, AA101, AA102, AA103, AA104, AA105, AA106, AA107, AA108, AA109, AA110, AA111, AA112, AA113, AA114, AA115, AA116, AA117, AA118, AA119, AA120, AA121, AA122, AA123, AA124, AA125, AA126, AA127, AA128, AA129, AA130, AA131, AA132, AA133, AA134, AA135, AA136, AA137, AA138, AA139, AA140, AA141, AA142, AA143, AA144, AA145, AA146, AA147, AA148, AA149, AA150, AA151, AA152, AA153, AA154, AA155, AA156, AA157, AA158, AA159, AA160, AA161, AA162, AA163, AA164, AA165, AA166, AA167, AA168, AA169, AA170, AA171, AA172,AA173, AA174, AA175, AA176, AA177, AA178, AA179, AA180, AA181, AA182, AA183, AA184, Bl, B2, B3, B4, B5, B6, B7, B8, B9, BIO, BB11, Cl, C2, C3, C4, C5, C6, C7, CC8, CC9, CC10, CC11, DI, D2, D3, D4, D5, D6, D7, D8, D9, DIO, Dl l, D12, D13, D14, D15, D16, D17, D18, D19, D20, D21, D22, D23, D24, D25, D26, D27, D28, D29, D30, D31, D32, D33, D34, D35, D36, D37, D38, D39, D40, D41, D42, D43, D44, D45, D46, D47, D48, D49, D50, D51, D52, D53, D54, D55, D56, D57, D58, D59, D60, D61, D62, D63, D64, D65, D66, D67, D68, D69, D70, D71, D72, D73, D74, D75, and D76, or a salt of any one thereof.

80. The compound or salt of claim 1, claim 6, or claim 55, wherein the compound is selected from: AAA185, AAA186, AAA187, AAA188, AAA189, AAA190, AAA191, AAA192, AAA193, AAA194, AAA195, AAA196, AAA197, AAA198, AAA199, AAA200, AAA201, AAA202, AAA203, AAA204, AAA205, AAA206, AAA207, AAA208, AAA209, AAA210, AAA211, AAA212, AAA213, AAA214, AAA215, AAA216, AAA217, AAA218, AAA219, AAA220, AAA221, AAA222, AAA223, AAA224, AAA225, AAA226, AAA227, AAA228, AAA229, AAA230, AAA231, AAA232, AAA233, AAA234, AAA235, AAA236, AAA237, AAA238, AAA239, AAA240, AAA241, AAA242, AAA243, AAA244, AAA245, AAA246, AAA247, AAA248, AAA249, AAA250, AAA251, AAA252, AAA253, AAA254, AAA255, AAA256, AAA257, AAA258, AAA259, AAA260, AAA261, AAA262, AAA263, AAA264, AAA265, AAA266, AAA267, AAA268, AAA269, AAA270, AAA271, AAA272, AAA273, AAA274, AAA275, AAA276, AAA277, AAA278, AAA279, AAA280, AAA281, AAA282, AAA283, AAA284, AAA285, AAA286, AAA287, AAA288, AAA289, AAA290, AAA291, AAA292, AAA293, AAA294, AAA295, AAA296, AAA297, AAA298, AAA299, AAA300, AAA301, AAA302, AAA303, AAA304, AAA305, AAA306, AAA307, AAA308, AAA309, AAA310, AAA311, AAA312, AAA313, AAA314, AAA315, AAA316, AAA317, AAA318, AAA319, AAA320, AAA321, AAA322, AAA323, AAA324, AAA325, AAA326, AAA327, AAA328, AAA329, AAA330, AAA331, AAA332, AAA333, AAA334, AAA335, AAA336, AAA337, AAA338, AAA339, AAA340, AAA341, AAA342, AAA343, AAA344, AAA345, AAA346, AAA347, AAA348, AAA349, AAA350, AAA351, AAA352, AAA353, AAA354, AAA355. CC12, CC13, CC14, CC15, CC16, CC17.

81. A pharmaceutical composition comprising a compound or salt of any one of claims 1 to 80 and a pharmaceutically acceptable excipient.

82. A method of treating a metabolic disease, a neuromuscular condition, a skeletal muscular condition, sarcopenia, muscle wasting, muscle spasm, inducing weight loss, or of inducing muscle gain, the method comprising administering to a patient in need thereof a compound or salt of any one of claims 1 to 80 or the pharmaceutical composition of claim 81.

83. A method of modulating myosin, the method comprising administering a therapeutically effective amount of a compound or salt of any one of claims 1 to 80 or the pharmaceutical composition of claim 81.

84. A method of modulating myosin, the method comprising administering a therapeutically effective amount of a compound of Formula (V-A):or a salt thereof, wherein:X31, X32, X33, and X34are each independently selected from C(R31), and N; each R31is independently selected from: hydrogen; halogen, -NO2, -CN, -OR40a, -SR40a, -N(R40a)2, -C(O)R40a, -C(O)N(R40a)2, - N(R40a)C(O)R40a-N(R40a)C(O)N(R40a)2, -OC(O)N(R40a)2, - N(R40a)C(O)OR40a, -C(O)OR40a, -OC(O)R40a, -S(O)R40a, and -S(O)2R40a;Ci-6 alkyl, C2-6 alkenyl, and C2.6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR40a, -SR40a, - N(R40a)2, -C(O)R40a, -C(O)N(R40a)2, -N(R40a)C(O)R40a-C(O)OR40a, -OC(O)R40a, - N(R40a)C(O)N(R40a)2, -OC(O)N(R40a)2, -N(R40a)C(O)OR40a, -S(O)R40a, -S(O)2R40a, -NO2, =0, =S, =N(R40a), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R39a; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR40a, - SR40a, -N(R40a)2, -C(O)R40a, -C(O)N(R40a)2, -N(R40a)C(O)R40a, -N(R40a)C(O)N(R40a)2, - OC(O)N(R40a)2, -N(R40a)C(O)OR40a, -C(O)OR40a, -OC(O)R40a, -S(O)R40a, -S(O)2R40a, - NO2, =0, =S, =N(R40a), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein Ci-s alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R39a;R32is selected from:Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR40b, -SR40b, - N(R40b)2, -C(O)R40b, -C(O)N(R40b)2, -N(R40b)C(O)R40b-C(O)OR40b, -OC(O)R40b, -N(R40b)C(O)N(R40b)2, -OC(O)N(R40b)2, -N(R40b)C(O)OR40b, -S(O)R40b, -S(O)2R40b, -NO2, =0, =S, =N(R40b), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R39b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR40b, -yl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R39b; or R32and R37come together to form a 7- to 15-membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OR40b, -SR40b, -N(R40b)2, -C(O)R40b, -C(O)N(R40b)2, - N(R40b)C(O)R40b-C(O)OR40b, -OC(O)R40b, -N(R40b)C(O)N(R40b)2, -OC(O)N(R40b)2, - N(R40b)C(O)OR40b, -S(O)R40b, -S(O)2R40b, -NO2, =0, =S, =N(R40b), and -CN;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR40b, -SR40b, -N(R40b)2, -C(O)R40b, -C(O)N(R40b)2, -N(R40b)C(O)R40b-C(O)OR40b, - OC(O)R40b, -N(R40b)C(O)N(R40b)2, -OC(O)N(R40b)2, -N(R40b)C(O)OR40b, -S(O)R40b, - S(O)2R40b, -NO2, =0, =S, =N(R40b), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R39b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR40b, -SR40b, -N(R40h)2, -C(O)R40b, -C(O)N(R40b)2, -N(R40b)C(O)R40b- N(R40b)C(O)N(R40b)2, -OC(O)N(R40b)2, -N(R40b)C(O)OR40b, -C(O)OR40b, -OC(O)R40b, -S(O)R40b, -S(O)2R40b, -NO2, =0, =S, =N(R40b), -CN, Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R39b;R37is selected from: hydrogen and Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR40e, -SR40e, -N(R40e)2, -NO2, and -CN; orR32and R37come together to form a 7- to 15-membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OR40b, -SR40b, -N(R40b)2, -C(O)R40b, -C(O)N(R40b)2, - N(R40b)C(O)R40b-C(O)OR40b, -OC(O)R40b, -N(R40b)C(O)N(R40b)2, -OC(O)N(R40b)2, - N(R40b)C(O)OR40b, -S(O)R40b, -S(O)2R40b, -NO2, =0, =S, =N(R40b), and -CN;Ci-6 alkyl, C2.6 alkenyl, and C2.6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR40b, -SR40b, -N(R40b)2, -C(O)R40b, -C(O)N(R40b)2, -N(R40b)C(O)R40b-C(O)OR40b, - OC(O)R40b, -N(R40b)C(O)N(R40b)2, -OC(O)N(R40b)2, -N(R40b)C(O)OR40b, -S(O)R40b, - S(O)2R40b, -NO2, =0, =S, =N(R40b), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R39b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR40b, -SR40h, -N(R40h)2, -C(O)R40b, -C(O)N(R40b)2, -N(R40b)C(O)R40b- N(R40b)C(O)N(R40b)2, -OC(O)N(R40b)2, -N(R40b)C(O)OR40b, -C(O)OR40b, -OC(O)R40b, -S(O)R40b, -S(O)2R40b, -NO2, -O, =S, ~N(R40b), -CN, Ci-6alkyl, C2.6alkenyl, C2.6alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R39b;R33and R34are each independently selected from: hydrogen, halogen, -OR40c, -SR40c, -N(R40c)2, -NO2, and -CN; andCi-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR40c, -SR400, -N(R40c)2, -N02, and -CN; orR33and R34come together to form a 5- to 10- membered spirocyclic heterocycle or C5-10 spirocyclic carbocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR40c, -SR40c, -N(R40c)2, -C(O)R40c, -C(O)N(R40c)2, - N(R40c)C(O)R4(k-C(O)OR40C, -OC(O)R40C, -N(R40C)C(O)N(R40C)2, -OC(O)N(R40C)2, - N(R40C)C(O)OR40C, -S(O)R40C, -S(O)2R40C, -NO2, =0, =S, =N(R40C), and -CN;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR40C, -SR40C, -N(R40C)2, -C(O)R40C, -C(O)N(R40C)2, -N(R40C)C(O)R40C, -C(O)OR40C, -OC(O)R40C, -N(R40C)C(O)N(R40C)2, -OC(O)N(R40C)2, -N(R40C)C(O)OR40C, -S(O)R40C, - S(O)2R40C, -NO2, =0, =S, =N(R40C), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R39c; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected fromalkynyl, wherein Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R39c; each R35and R36independently selected from: hydrogen, halogen, -OR40d, -SR40d, -N(R40d)2, -NO2, and -CN;Ci-6 alkyl, C2-6 alkenyl, and C2-e alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR40d, -SR40d, - N(R40d)2, -C(O)R40d, -C(O)N(R40d)2, -N(R40d)C(O)R40d-C(O)OR40d, -OC(O)R40d, - N(R40d)C(O)N(R40d)2, -OC(O)N(R40d)2, -N(R40d)C(O)OR40d, -S(O)R40d, -S(O)2R40d, -NO2, =0, =S, =N(R40d), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R39c; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR40d, - SR40d, -N(R40d)2, -N02, and -CN; orR35together with R36form a 3 - to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more R39c;R38is selected from: hydrogen; andCi-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR40f, -SR40f, -N(R40f)2, -NO2, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle are optionally substituted with one or more substituents independently selected from halogen, -OR40f, -SR40f, -N(R40f)2, -NO2, and -CN; each R39a, R39b, R39c, are independently selected from:halogen, -OR40g, -SR40g, -N(R40g)2, -C(O)R40g, -C(O)N(R40g)2, -N(R40g)C(O)R40g-Ci-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR40g, -SR40g, - N(R40g)2, -C(O)R40g, -C(O)N(R40g)2, -N(R40g)C(O)R40g-N(R40g)C(O)N(R40g)2, - OC(O)N(R40g)2, -N(R40g)C(O)OR40g, -C(O)OR40g, -OC(O)R40g, -S(O)R40g, -S(O)2R40g, - N02, =0, =S, =N(R40g), and -CN; and each R40a, R40b, R40c, R40dR40e, R40f, and R40gis independently selected from: hydrogen;Ci-6 alkyl, C2-6 alkenyl, and C2-e alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - N02, -NH2, =0, =S, -O-Ci-6 alkyl, -S-Ci-6alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -N02, -NH2, -O, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-e haloalkyl.

85. A method of treating a metabolic disease, diabetes, a neuromuscular condition, a skeletal muscular condition, sarcopenia, muscle wasting, muscle spasm, inducing weight loss, or of inducing muscle gain in an individual in need thereof, the method comprising administering a therapeutically effective amount of a compound of Formula (V):or a salt thereof, wherein:X31, X32, X33, and X34are each independently selected from C(R31), and N; each R31is independently selected from: hydrogen;halogen, -NO2, -CN, -OR40a, -SR40a, -N(R40a)2, -C(O)R40a, -C(O)N(R40a)2, - N(R40a)C(O)R40a, -N(R40a)C(O)N(R40a)2, -OC(O)N(R40a)2, - N(R40a)C(O)OR40a, -C(O)OR40a, -OC(O)R40a, -S(O)R40a, and -S(O)2R40a;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR40a, -SR40a, - N(R40a)2, -C(O)R40a, -C(O)N(R40a)2, -N(R40a)C(O)R40a, -C(O)OR40a, -OC(O)R40a, - N(R40a)C(O)N(R40a)2, -OC(O)N(R40a)2, -N(R40a)C(O)OR40a, -S(O)R40a, -S(O)2R40a, -NO2, =0, =S, =N(R40a), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R39a; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR40a, - SR40a, -N(R40a)2, -C(O)R40a, -C(O)N(R40a)2, -N(R40a)C(O)R40a, -N(R40a)C(O)N(R40a)2, - OC(O)N(R40a)2, -N(R40a)C(O)OR40a, -C(O)OR40a, -OC(O)R40a, -S(O)R40a, -S(O)2R40a, - NO2, =0, =S, =N(R40a), -CN, C1-6 alkyl, C2.6 alkenyl, and C2.6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R39a;R32is selected from:Ci-6 alkyl, C2-6 alkenyl, and C2.6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR40b, -SR40b, - N(R40b)2, -C(O)R40b, -C(O)N(R40b)2, -N(R40b)C(O)R40b-C(O)OR40b, -OC(O)R40b, - N(R40b)C(O)N(R40b)2, -OC(O)N(R40b)2, -N(R40b)C(O)OR40b, -S(O)R40b, -S(O)2R40b, -NO2, =0, =S, =N(R40b), -CN, C3-io carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R39b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR40b, - SR40b, -N(R40h)2, -C(O)R40b, -C(O)N(R40b)2, -N(R40b)C(O)R40b-N(R40b)C(O)N(R40b)2, - OC(O)N(R40b)2, -N(R40b)C(O)OR40b, -C(O)OR40h, -OC(O)R40b, -S(O)R40b, -S(O)2R40b, - NO2, =0, =S, =N(R40h), -CN, Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R39b; orR32and R37come together to form a 7- to 15-membered heterocycle optionally substituted with one or more substituents independently selected from:Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR40b, -SR40b, -N(R40b)2, -C(O)R40b, -C(O)N(R40b)2, -N(R40b)C(O)R40b-C(O)OR40b, - OC(O)R40b, -N(R40b)C(O)N(R40b)2, -OC(O)N(R40b)2, -N(R40b)C(O)OR40b, -S(O)R40b, - S(O)2R40b, -N02, =0, =S, =N(R40b), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R39b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR40b, -SR40b, -N(R40h)2, -C(O)R40b, -C(O)N(R40b)2, -N(R40b)C(O)R40b- N(R40b)C(O)N(R40b)2, -OC(O)N(R40b)2, -N(R40b)C(O)OR40b, -C(O)OR40b, -OC(O)R40b, -S(O)R40b, -S(O)2R40b, -N02, =0, =S, =N(R40b), -CN, Ci-6alkyl, C2.6alkenyl, and C2.6alkynyl, wherein Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R39b;R37is selected from: hydrogen and Ci-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR40e, -SR40e, -N(R40e)2, -N02, and -CN; orR32and R37come together to form a 7- to 15-membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OR40b, -SR40b, -N(R40b)2, -C(O)R40b, -C(O)N(R40b)2, - N(R40b)C(O)R40b-C(O)OR40b, -OC(O)R40b, -N(R40b)C(O)N(R40b)2, -OC(O)N(R40b)2, - N(R40b)C(O)OR40b, -S(O)R40b, -S(O)2R40b, -N02, =0, =S, =N(R40b), and -CN;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR40b, -SR40b, -N(R40b)2, -C(O)R40b, -C(O)N(R40b)2, -N(R40b)C(O)R40b-C(O)OR40b, - OC(O)R40b, -N(R40b)C(O)N(R40b)2, -OC(O)N(R40b)2, -N(R40b)C(O)OR40b, -S(O)R40b, - S(O)2R40b, -N02, =0, =S, =N(R40b), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R39b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected fromalkynyl, wherein Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R39b;R33and R34are each independently selected from: hydrogen, halogen, -OR40c, -SR40c, -N(R40c)2, -N02, and -CN; andCi-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR40c, -SR400, -N(R40c)2, -N02, and -CN; orR33and R34come together to form a 5- to 10- membered spirocyclic heterocycle or C5-10 spirocyclic carbocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR40c, -SR40c, -N(R40c)2, -C(O)R40c, -C(O)N(R40c)2, - N(R40C)C(O)R40C, -C(O)OR40C, -OC(O)R40C, -N(R40C)C(O)N(R40C)2, -OC(O)N(R40C)2, - N(R40C)C(O)OR40C, -S(O)R40C, -S(O)2R40C, -NO2, =0, =S, =N(R40C), and -CN;Ci-6 alkyl, C2-6 alkenyl, and C2.g alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR40c, -SR40c, - N(R40C)2, -C(O)R40C, -C(O)N(R40C)2, -N(R40C)C(O)R40C, -C(O)OR40C, -OC(O)R40C, - N(R40C)C(O)N(R40C)2, -OC(O)N(R40C)2, -N(R40C)C(O)OR40C, -S(O)R40C, -S(O)2R40C, -NO2, =0, =S, =N(R40C), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R39c; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR40c, - SR40C, -N(R40C)2, -C(O)R40C, -C(O)N(R40C)2, -N(R40C)C(O)R40C, -N(R40C)C(O)N(R40C)2, - OC(O)N(R40C)2, -N(R40C)C(O)OR40C, -C(O)OR40C, -OC(O)R40C, -S(O)R40C, -S(O)2R40C, - N02, =0, =S, =N(R40C), -CN, Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R39c; each R35and R36independently selected from: hydrogen, halogen, -OR40d, -SR40d, -N(R40d)2, -N02, and -CN;Ci-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR40d, -SR40d, - N(R40d)2, -C(O)R40d, -C(O)N(R40d)2, -N(R40d)C(O)R40d-C(O)OR40d, -OC(O)R40d, - N(R40d)C(O)N(R40d)2, -OC(O)N(R40d)2, -N(R40d)C(O)OR40d, -S(O)R40d, -S(O)2R40d, -N02,=0, =S, =N(R40d), -CN, C3-io carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R39c; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR40d, - SR40d, -N(R40d)2, -NO2, and -CN; orR35together with R36form a 3 - to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more R39c,R38is selected from: hydrogen; andCi-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR40f, -SR40f, -N(R40f)2, -NO2, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle are optionally substituted with one or more substituents independently selected from halogen, -OR40f, -SR40f, -N(R40f)2, -NO2, and -CN; each R39a, R39b, R39c, are independently selected from: halogen, -OR40g, -SR40g, -N(R40g)2, -C(O)R40g, -C(O)N(R40g)2, -N(R40g)C(O)R40g- N(R40g)C(O)N(R40g)2, -OC(O)N(R40g)2, -N(R40g)C(O)OR40g, -C(O)OR40g, -OC(O)R40g, - S(O)R40g, -S(O)2R40g, -NO2, =0, =S, =N(R40g), and -CN; andC1.3 alkyl, C2-3 alkenyl, and C2.3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR40g, -SR40g, - N(R40g)2, -C(O)R40g, -C(O)N(R40g)2, -N(R40g)C(O)R40g-N(R40g)C(O)N(R40g)2, - OC(O)N(R40g)2, -N(R40g)C(O)OR40g, -C(O)OR40g, -OC(O)R40g, -S(O)R40g, -S(O)2R40g, - NO2, =0, =S, =N(R40g), and -CN; and each R40a, R40b, R40c, R40dR40e, R40f, and R40gis independently selected from: hydrogen;C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - NO2, -NH2, =0, =S, -O-C1-6 alkyl, -S-Ci-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; andC3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, - OH, -SH, -NO2, -NH2, =0, =S, -O-C1.6 alkyl, -S-C1-6 alkyl, -N(CI-6alkyl)2, -NH(CI-6alkyl), Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and Ci-e haloalkyl.

86. The method of claim 85, wherein the metabolic disease is obesity.

87. The method of any one of claims 84 to 86, further comprising the administration of a second therapeutic agent.

88. The method of claim 87, wherein the second therapeutic agent comprises a GLP-1 modulator or SGLT2 modulator, GIP modulator, a secretagogue, or alpha-glucosidase modulator.

89. A method of extending the amount of time muscle fibers reside in a DRX state or increasing the population of muscle fibers residing in the DRX state, the method comprising administering to a patient in need thereof a compound or salt of any one of claims 1 to 80 or the pharmaceutical composition of claim 81.

90. A method of extending the amount of time muscle fibers reside in a DRX state or increasing the population of muscle fibers residing in the DRX state, the method comprising administering to a patient in need thereof the compound or salt of claim 85.

91. The method of any one of claims 82 to 90, wherein the compound is not a compound of List 1, or a salt of any thereof.

92. The method of claim any one of claims 82 to 90, wherein the amount of time muscle fibers reside in a DRX state is increased by 5% or more.

93. The method of claim any one of claims 82 to 90, wherein the population of muscle fibers residing in the DRX state is increased by 5% or more.

94. The method of claim any one of claims 82 to 90, wherein the resting energy consumption rate of the subject is increased 5% or more.

95. The method of any one of claims 82 to 90, wherein the myosin is skeletal myosin, and the modulation is activation.

96. The method of any one of claims 82 to 90, wherein the modulation is skeletal activation, and the method is for inducing weight loss; inducing muscle gain; extending the amount of time muscle fibers reside in a DRX state; increasing the population of muscle fibers residing in the DRX state; or treating a condition selected from: a metabolic disease, activity -induced muscle damage, a neuromuscular condition, a skeletal muscular condition, sarcopenia, muscle wasting, and muscle spasm.

97. The method claim 96, wherein the method is for treating obesity.

98. A method of treating a metabolic disease, a neuromuscular condition, a skeletal muscular condition, sarcopenia, muscle wasting, muscle spasm, inducing weight loss, or of inducing muscle gain, the method comprising administering to a patient in need thereof a compound orsalt of any one of claims 1 to 80, wherein the compound is selected from: Al, A2, A3, A4, A5 A6, A7, A8, A9, A10, Al 1, A12, A13, A14, A15, A16, A17, A18, A19, A20, A21, A22, A23, A24, A25, A26, A27, A28, A29, A30, A31, A32, A33, AA34, AA35, AA36, AA37, AA38, AA39, AA40, AA41, AA42, AA43, AA44, AA45, AA46, AA47, AA48, AA49, AA50, AA51 AA52, AA53, AA54, AA55, AA56, AA57, AA58, AA59, AA60, AA61, AA62, AA63, AA64 AA65, AA66, AA67, AA68, AA69, AA70, AA71, AA72, AA73, AA74, AA75, AA76, AA77 AA78, AA79, AA80, AA81, AA82, AA83, AA84, AA85, AA86, AA87, AA88, AA89, AA90 AA91, AA92, AA93, AA94, AA95, AA96, AA97, AA98, AA99, AA100, AA101, AA102, AA103, AA104, AA105, AA106, AA107, AA108, AA109, AA110, AA111, AA112, AA113, AA114, AA115, AA116, AA117, AA118, AA119, AA120, AA121, AA122, AA123, AA124, AA125, AA126, AA127, AA128, AA129, AA130, AA131, AA132, AA133, AA134, AA135, AA136, AA137, AA138, AA139, AA140, AA141, AA142, AA143, AA144, AA145, AA146, AA147, AA148, AA149, AA150, AA151, AA152, AA153, AA154, AA155, AA156, AA157, AA158, AA159, AA160, AA161, AA162, AA163, AA164, AA165, AA166, AA167, AA168, AA169, AA170, AA171, AA172, AA173, AA174, AA175, AA176, AA177, AA178, AA179, AA180. AA181. AA182. AA183. AA184. AAAI 85. AAAI 86. AAAI 87. AAAI 88. AAAI 89.AAAI 90, AAAI 91, AAAI 92, AAA 193, AAA 194, AAAI 95, AAAI 96, AAAI 97, AAAI 98, AAAI 99, AAA200, AAA201, AAA202, AAA203, AAA204, AAA205, AAA206, AAA207, AAA208, AAA209, AAA210, AAA211, AAA212, AAA213, AAA214, AAA215, AAA216, AAA217, AAA218, AAA219, AAA220, AAA221, AAA222, AAA223, AAA224, AAA225, AAA226, AAA227, AAA228, AAA229, AAA230, AAA231, AAA232, AAA233, AAA234, AAA235, AAA236, AAA237, AAA238, AAA239, AAA240, AAA241, AAA242, AAA243, AAA244, AAA245, AAA246, AAA247, AAA248, AAA249, AAA250, AAA251, AAA252, AAA253, AAA254, AAA255, AAA256, AAA257, AAA258, AAA259, AAA260, AAA261, AAA262, AAA263, AAA264, AAA265, AAA266, AAA267, AAA268, AAA269, AAA270, AAA271, AAA272, AAA273, AAA274, AAA275, AAA276, AAA277, AAA278, AAA279, AAA280, AAA281, AAA282, AAA283, AAA284, AAA285, AAA286, AAA287, AAA288, AAA289, AAA290, AAA291, AAA292, AAA293, AAA294, AAA295, AAA296, AAA297, AAA298, AAA299, AAA300, AAA301, AAA302, AAA303, AAA304, AAA305, AAA306, AAA307, AAA308, AAA309, AAA310, AAA311, AAA312, AAA313 , AAA314, AAA315 , AAA316, AAA317, AAA318, AAA319, AAA320, AAA321, AAA322, AAA323, AAA324, AAA325, AAA326, AAA327, AAA328, AAA329, AAA330, AAA331, AAA332, AAA333, AAA334, AAA335, AAA336, AAA337, AAA338, AAA339, AAA340, AAA341, AAA342, AAA343, AAA344, AAA345, AAA346, AAA347, AAA348, AAA349, AAA350, AAA351,AAA352, AAA353, AAA354, AAA355,B1, B2, B3, B4, B5, B6, B7, B8, B9, BIO, BB11, Cl, C2, C3, C4, C5, C6, C7, CC8, CC9, CC1O, CC11, CC12, CC13, CC14, CC15, CC16, CC17, DI, D2, D3, D4, D5, D6, D7, D8, D9, DIO, Dl l, D12, D13, D14, D15, D16, D17, D18, D19, D20, D21, D22, D23, D24, D25, D26, D27, D28, D29, D3O, D31, D32, D33, D34, D35, D36, D37, D38, D39, D40, D41, D42, D43, D44, D45, D46, D47, D48, D49, D5O, D51, D52, D53, D54, D55, D56, D57, D58, D59, D60, D61, D62, D63, D64, D65, D66, D67, D68, D69, D70, D71, D72, D73, D74, D75, and D76, or a salt of any one thereof.

99. A method of treating a metabolic disease, a neuromuscular condition, a skeletal muscular condition, sarcopenia, muscle wasting, muscle spasm, inducing weight loss, or of inducing muscle gain, the method comprising administering to a patient in need thereof a compound or salt of any one of claims 1 to 80, wherein the compound is selected from: Al, A2, A3, A4, A5, A6, A7, A8, A9, A10, Al 1, A12, A13, A14, A15, A16, A17, A18, A19, A20, A21, A22, A23, A24, A25, A26, A27, A28, A29, A30, A31, A32, A33, AA34, AA35, AA36, AA37, AA38, AA39, AA40, AA41, AA42, AA43, AA44, AA45, AA46, AA47, AA48, AA49, AA50, AA51, AA52, AA53, AA54, AA55, AA56, AA57, AA58, AA59, AA60, AA61, AA62, AA63, AA64, AA65, AA66, AA67, AA68, AA69, AA70, AA71, AA72, AA73, AA74, AA75, AA76, AA77, AA78, AA79, AA80, AA81, AA82, AA83, AA84, AA85, AA86, AA87, AA88, AA89, AA90, AA91, AA92, AA93, AA94, AA95, AA96, AA97, AA98, AA99, AA100, AA101, AA102, AA103, AA104, AA105, AA106, AA107, AA108, AA109, AA110, AA111, AA112, AA113, AA114, AA115, AA116, AA117, AA118, AA119, AA120, AA121, AA122, AA123, AA124, AA125, AA126, AA127, AA128, AA129, AA130, AA131, AA132, AA133, AA134, AA135, AA136, AA137, AA138, AA139, AA140, AA141, AA142, AA143, AA144, AA145, AA146, AA147, AA148, AA149, AA150, AA151, AA152, AA153, AA154, AA155, AA156, AA157, AA158, AA159, AA160, AA161, AA162, AA163, AA164, AA165, AA166, AA167, AA168, AA169, AA170, AA171, AA172, AA173, AA174, AA175, AA176, AA177, AA178, AA179, AA180, AA181, AA182, AA183, AA184, Bl, B2, B3, B4, B5, B6, B7, B8, B9, BIO, BB11, Cl, C2, C3, C4, C5, C6, C7, CC8, CC9, CC10, CC11, DI, D2, D3, D4, D5, D6, D7, D8, D9, DIO, Dl l, D12, D13, D14, D15, D16, D17, D18, D19, D20, D21, D22, D23, D24, D25, D26, D27, D28, D29, D30, D31, D32, D33, D34, D35, D36, D37, D38, D39, D40, D41, D42, D43, D44, D45, D46, D47, D48, D49, D50, D51, D52, D53, D54, D55, D56, D57, D58, D59, D60, D61, D62, D63, D64, D65, D66, D67, D68, D69, D70, D71, D72, D73, D74, D75, and D76, or a salt of any one thereof.

Images