Temperature control structure of reaction equipment and temperature control method for progesterone production

Abstract

The present invention provides a temperature control structure of a reaction equipment, comprising a C-shaped reaction part and a driving part connected between two ends of the reaction part. The driving part and the reaction part form an annular shape, and the reaction part and the driving part defines a reaction cavity; a feeding channel is communicated with the top of the reaction part, a discharging channel is communicated with the bottom of the reaction part, and a control valve is arranged on the discharging channel; driving blades are positioned in the driving part and are used for driving liquid in the reaction cavity to circulate; heat exchange tubes vertically pass through the reaction part, a plurality of heat exchange tubes are vertically arranged on the reaction part, and heat exchange channels vertically pass through the heat exchange tubes; and all the heat exchange tubes are communicated with a medium introduction mechanism. The temperature control structure of the reaction equipment provided by the present invention can improve the reaction efficiency.

Description

A temperature control structure for a reaction apparatus and a temperature control method for progesterone production. Technical Field

[0001] This invention belongs to the field of progesterone production technology, and relates to a temperature control structure for a reaction device and a temperature control method for progesterone production. Background Technology

[0002] Progesterone, also known as luteal hormone, is the main biologically active progestin secreted by the ovary, with the chemical formula C64. 21 H 30 O2. Before ovulation, the daily production of progesterone is 2-3 mg, mainly from the ovaries. Progesterone protects the uterine lining. During pregnancy, progesterone provides support and protection for early fetal growth and development, and also has a calming effect on the uterus. Furthermore, progesterone and estrogen are inextricably linked; both are crucial female hormones. Estrogen primarily promotes the development and maturation of secondary sexual characteristics, while progesterone, building upon the effects of estrogen, further promotes the development and maturation of these characteristics; the two have a synergistic effect.

[0003] Currently, a Chinese patent with publication number CN113845556A discloses a method for preparing progesterone. This method involves mixing several materials and then performing an elimination oxidation reaction to artificially produce progesterone. The above process typically uses a reaction vessel, which is also a container for many chemical reactions. Furthermore, some reaction vessels requiring heating and / or cooling have coils installed on their outer walls, through which a refrigerant or heat transfer medium is circulated. Heat exchange occurs between the refrigerant and the material inside the vessel via the inner wall. However, due to the large diameter of the reaction vessel and the large amount of liquid inside, the liquid near the side wall of the vessel tends to have a faster heat exchange rate, resulting in a large temperature difference between the inside and outside, leading to an excessively long overall reaction time and low reaction efficiency.

[0004] Summary of the Invention

[0005] The purpose of this invention is to provide a temperature control structure for a reaction apparatus and a temperature control method for progesterone production, aiming to solve the problem of low reaction efficiency.

[0006] To solve the above-mentioned technical problems, the present invention provides a temperature control structure for a reaction apparatus, comprising:

[0007] The reaction section is C-shaped and the driving section is connected between the two ends of the reaction section. The driving section and the reaction section form an annular ring, and the reaction section and the driving section are hollow reaction cavities.

[0008] The feed channel is connected to the top of the reaction section, and the discharge channel is connected to the bottom of the reaction section. A control valve is provided on the discharge channel.

[0009] A driving blade, located inside the driving section, is used to drive the liquid in the reaction cavity to circulate.

[0010] A heat exchange tube is provided, which vertically penetrates the reaction section, and a plurality of heat exchange tubes are vertically arranged on the reaction section, with heat exchange channels opened in the vertically penetrating heat exchange tubes;

[0011] The media introduction mechanism is connected to all the heat exchange tubes.

[0012] The present invention is further configured such that the bottom of the driving part is higher than the bottom of the reaction part, the bottom of the reaction part is inclined, and the discharge channel is connected to the bottom of the inner wall of the reaction part.

[0013] The present invention is further configured such that two support frames are vertically arranged on the inner wall of the drive unit, a support rod is horizontally rotatably arranged between the two support frames, a plurality of drive blades are inclinedly arranged on the outer wall of the support rod, and a passive bevel tooth is provided at one end of the support rod;

[0014] A drive rod is horizontally disposed through the drive unit, and the drive rod is rotatably connected to the drive unit. A drive motor for driving the drive rod to rotate is disposed outside the drive rod, and an active bevel tooth that meshes with the passive bevel tooth is disposed on the drive rod.

[0015] The present invention is further configured such that the media inlet mechanism includes a media inlet cover and a media outlet cover, the media inlet cover being an upward-opening cover and the media outlet cover being a downward-opening cover, the top of the media outlet cover being connected to the bottom of the reaction section and the media outlet cover being connected to the top of the reaction section, and both ends of the heat exchange channel being connected to the media inlet cover and the media outlet cover.

[0016] The bottom of the media inlet cover is connected to an inlet tube, and an inlet pump is installed on the inlet tube. The top of the media outlet cover is connected to an outlet tube.

[0017] The present invention is further configured such that a flow equalization plate is horizontally arranged on the inner wall of the media inlet cover, and a plurality of flow equalization holes are opened through the flow equalization plate, and a set distance is provided between the flow equalization plate and the top and bottom of the media inlet cover.

[0018] The present invention is further configured such that the inlet tube is connected to the middle part of the bottom end of the media inlet cover.

[0019] The present invention is further configured such that a flow equalization frame is provided at the bottom of the inner wall of the media inlet cover, and a rotating rod is vertically rotatably mounted on the flow equalization frame. The bottom of the rotating rod is directly opposite the connection between the inlet pipe and the media inlet cover. A plurality of rotating plates are evenly arranged in a divergent pattern on the outer wall of the rotating rod. The longitudinal section of the rotating plate is inclined. When the fluid flows upward, the fluid can drive the rotating rod to rotate through the rotating plate.

[0020] The invention is further configured such that a plurality of arc-shaped dispersing elements are horizontally arranged at the top of the rotating rod, and the dispersing elements are used to drive fluid flow toward the periphery.

[0021] The present invention is further configured such that a rotating cylinder is vertically arranged at the top of the flow equalization frame, and the inner wall of the rotating rod is movably attached to the inner wall of the rotating cylinder.

[0022] The present invention also provides a temperature control method for progesterone production, which uses a temperature control structure of a reaction apparatus as described in any of the preceding claims for temperature control, and includes the following steps:

[0023] S1, the reactants are added to the reaction section through the feeding channel in proportion;

[0024] S2, continuously inject nitrogen gas into the reaction cavity until the reaction is complete;

[0025] S3, the driving blade drives the fluid in the reaction cavity to circulate;

[0026] S4, the heat medium flows into each heat exchange channel through the media introduction mechanism, where the temperature of the heat medium is maintained at 40-50℃.

[0027] Compared with existing technologies, this invention provides a temperature control structure for a reaction apparatus. During temperature control, the reactants are first added to the reaction chamber through a feeding channel in a specific ratio. Then, a drive blade circulates the fluid within the reaction cavity, while a heating or cooling medium flows into each heat exchange channel through a media introduction mechanism. During circulation, heat exchange is effectively achieved between the heat exchanger and the outer wall of the heat exchange tubes. Furthermore, since the heat exchange tubes are located inside the fluid, the fluid flow also agitates the fluid, allowing more liquid to contact the outer wall of the heat exchange tubes, further improving heat exchange quality and ensuring that the fluid in all areas fully interacts with the heat exchange tubes. Simultaneously, because the reaction cavity is an annular channel, the drive blades ensure more uniform mixing of the materials during fluid circulation, preventing sedimentation and ensuring the normal progress of the reaction.

[0028] It should also be understood that, in actual use, this application can be used in the production process of progesterone, or in any other reaction that requires heat exchange, and the heat exchange can be either heating or cooling. Attached Figure Description

[0029] Figure 1 is a schematic diagram of an embodiment of the temperature control structure of a reaction device according to the present invention;

[0030] Figure 2 is a cross-sectional view of an embodiment of the temperature control structure of a reaction device according to the present invention;

[0031] Figure 3 is an enlarged view of part A in Figure 2;

[0032] Figure 4 is a second cross-sectional view of an embodiment of the temperature control structure of a reaction device according to the present invention;

[0033] Figure 5 is an enlarged view of part B in Figure 4;

[0034] Figure 6 is a schematic diagram of an embodiment of the rotating plate portion in the temperature control structure of a reaction device according to the present invention.

[0035] Figure 7 is a schematic diagram of an embodiment of the flow equalization plate in the temperature control structure of a reaction device according to the present invention.

[0036] The components are as follows: 1. Reaction section; 2. Drive section; 3. Feeding channel; 4. Discharge channel; 5. Control valve; 6. Drive blade; 7. Heat exchange tube; 8. Support frame; 9. Support rod; 10. Passive bevel gear; 11. Drive rod; 12. Drive motor; 13. Active bevel gear; 14. Media inlet cover; 15. Media outlet cover; 16. Inlet pipe; 17. Inlet pump; 18. Outlet pipe; 19. Flow equalization plate; 20. Flow equalization hole; 21. Flow equalization frame; 22. Rotating rod; 23. Rotating plate; 24. Dispersing component; 25. Rotating cylinder. Detailed Implementation

[0037] The following detailed description, in conjunction with the accompanying drawings and specific embodiments, provides a further detailed explanation of the temperature control structure of a reaction apparatus and the temperature control method for progesterone production proposed in this invention. The advantages and features of this invention will become clearer from the following description. It should be noted that the accompanying drawings are all in a very simplified form and use non-precise proportions, and are only used to facilitate and clarify the illustration of the embodiments of this invention. The same or similar reference numerals in the drawings represent the same or similar parts.

[0038] A temperature control structure for a reaction apparatus, as shown in Figures 1 to 7, includes:

[0039] The reaction section 1 is C-shaped and the driving section 2 is connected between the two ends of the reaction section 1. The driving section 2 and the reaction section 1 form an annular ring, and the reaction section 1 and the driving section 2 are hollow reaction cavities.

[0040] Feeding channel 3 and discharging channel 4, wherein feeding channel 3 is connected to the top of reaction section 1 and discharging channel 4 is connected to the bottom of reaction section 1, and a control valve 5 is provided on discharging channel 4;

[0041] Drive blade 6, located inside the drive unit 2, is used to drive the liquid in the reaction cavity to circulate;

[0042] The heat exchange tube 7 vertically penetrates the reaction section 1, and a plurality of the heat exchange tubes 7 are vertically arranged on the reaction section 1, with heat exchange channels opened through the vertically penetrating heat exchange tubes 7.

[0043] Media introduction mechanism, all heat exchange tubes 7 are connected to the media introduction mechanism.

[0044] The bottom of the drive unit 2 is higher than the bottom of the reaction unit 1, the bottom of the reaction unit 1 is inclined, and the discharge channel 4 is connected to the bottom of the inner wall of the reaction unit 1.

[0045] The inner wall of the drive unit 2 is vertically provided with two support frames 8, and a support rod 9 is horizontally rotatably provided between the two support frames 8. Several drive blades 6 are inclinedly provided on the outer wall of the support rod 9, and a passive bevel tooth 10 is provided at one end of the support rod 9.

[0046] A drive rod 11 is horizontally disposed through the drive unit 2. The drive rod 11 is rotatably connected to the drive unit 2. A drive motor 12 for driving the drive rod 11 to rotate is disposed outside the drive rod 11. An active bevel tooth 13 that meshes with the passive bevel tooth 10 is disposed on the drive rod 11.

[0047] The media inlet mechanism includes a media inlet cover 14 and a media outlet cover 15. The media inlet cover 14 is an open-facing cover, and the media outlet cover 15 is an open-facing cover. The top of the media outlet cover 15 is connected to the bottom of the reaction section 1, and the media outlet cover 15 is connected to the top of the reaction section 1. Both ends of the heat exchange channel are connected to the media inlet cover 14 and the media outlet cover 15.

[0048] The bottom of the media inlet cover 14 is connected to an inlet tube 16, and an inlet pump 17 is provided on the inlet tube 16. The top of the media outlet cover 15 is connected to an outlet tube 18.

[0049] The media inlet cover 14 has a horizontally arranged flow equalization plate 19 on its inner wall, and a plurality of flow equalization holes 20 are opened through the flow equalization plate 19. The flow equalization plate 19 is at a set distance from the top and bottom of the media inlet cover 14.

[0050] The inlet pipe 16 is connected to the middle of the bottom end of the media inlet cover 14. A flow equalization frame 21 is provided at the bottom of the inner wall of the media inlet cover 14. A rotating rod 22 is vertically rotatably mounted on the flow equalization frame 21. The bottom of the rotating rod 22 is directly opposite the connection between the inlet pipe 16 and the media inlet cover 14. Several rotating plates 23 are evenly arranged in a radiating pattern on the outer wall of the rotating rod 22. The longitudinal section of the rotating plate 23 is inclined. When the fluid flows upward, the fluid can drive the rotating rod 22 to rotate through the rotating plate 23.

[0051] The top of the rotating rod 22 is horizontally provided with several arc-shaped dispersing members 24, which are used to drive fluid flow to the periphery. The top of the flow equalization frame 21 is vertically provided with a rotating cylinder 25, and the inner wall of the rotating rod 22 is movably attached to the inner wall of the rotating cylinder 25.

[0052] The present invention also provides a temperature control method for progesterone production, which uses a temperature control structure of a reaction apparatus as described in any of the preceding claims for temperature control, and includes the following steps:

[0053] S1, the reactants are added to the reaction section 1 through the feeding channel 3 in proportion;

[0054] S2, continuously inject nitrogen gas into the reaction cavity until the reaction is complete;

[0055] S3, driving blade 6 drives the fluid in the reaction cavity to circulate;

[0056] S4, the heat medium flows into each heat exchange channel through the media introduction mechanism, where the temperature of the heat medium is maintained at 40-50℃.

[0057] This invention provides a temperature control structure for a reaction apparatus and a temperature control method for progesterone production. During temperature control, the reactants are first added to the reaction section 1 via the feeding channel 3 in a specific ratio. Then, the drive blade 6 drives the fluid within the reaction cavity to circulate, while a heating or cooling medium flows into each heat exchange channel through a media introduction mechanism. During the circulation process, heat exchange is effectively achieved between the fluid and the outer wall of the heat exchange tube 7. Furthermore, since the heat exchange tube 7 is located inside the fluid, the fluid flow also agitates the fluid, allowing more liquid to contact the outer wall of the heat exchange tube 7, further improving the heat exchange quality and ensuring that the fluid in all areas fully interacts with the heat exchange tube 7. Simultaneously, because the reaction cavity is an annular channel, the drive blade 6, while driving the fluid circulation, ensures more uniform mixing of the materials, preventing sedimentation and ensuring the normal progress of the reaction.

[0058] Because multiple heat exchange tubes 7 can simultaneously exchange heat with all flowing fluids, the heat exchange rate is faster, thereby accelerating the reaction and production speed and improving production efficiency. Furthermore, since some reactions require precise temperature control, separating the heat or cold medium into each heat exchange channel ensures the normal progress of the reaction.

[0059] It should also be understood that, in actual use, this application can be used in the production process of progesterone, or in any other reaction that requires heat exchange, and the heat exchange can be either heating or cooling.

[0060] After all the materials are added into the reaction cavity, the drive motor 12 drives the drive rod 11 to rotate. The drive rod 11 drives the support rod 9 to rotate through the active bevel gear 13 and the passive bevel gear 10. The support rod 9 drives all the drive blades 6 on its outer wall to rotate, thereby driving the materials to flow forward and forming a cycle. After the reaction is completed, the control valve 5 at the bottom is opened, and the internal fluid flows downward. Since the bottom of the inner wall of the reaction section 1 is lower than the bottom of the inner wall of the drive section 2, and the discharge channel 4 is connected to the lowest point of the bottom of the reaction section 1, the materials can flow out to the maximum extent. Secondly, when rinsing the inner wall, the cleaning water can be discharged to the outside more effectively.

[0061] When the medium is introduced (in this embodiment, the heat medium is used as an example), the introduction pump 17 is started. The heat medium in the heat medium chamber is introduced into the medium introduction cover 14 through the introduction pipe 16 and fills the medium introduction cover 14. Then, it passes through the heat exchange channel from bottom to top and finally reaches the medium outlet cover 15 and flows out through the outlet pipe 18. As the heat medium flows upward, it acts on the inclined rotating plate 23, causing the plate to shift and driving the rotating rod 22 to rotate. Simultaneously, as the rotating rod 22 rotates, its top arc-shaped dispersing element 24 drives the fluid to flow towards its periphery. This disperses the heat medium at the inlet pipe 16, allowing it to flow more evenly into each heat exchange channel, resulting in better heat exchange uniformity. Furthermore, during its upward flow, the heat medium is blocked by the flow equalization plate 19 and then flows upward through multiple flow equalization holes 20, further dispersing the fluid and ensuring more even flow into each heat exchange channel. This prevents localized overheating (or, in the case of refrigerant, localized undertemperature), further enhancing reaction uniformity. The rotating rod 22 is also supported by the rotating cylinder 25, improving its position and rotational stability.

[0062] The above description is merely a description of preferred embodiments of the present invention and is not intended to limit the scope of the present invention in any way. Any changes or modifications made by those skilled in the art based on the above disclosure shall fall within the protection scope of the claims.

Claims

1. A temperature control structure for a reaction apparatus, characterized in that, include: The reaction section (1) is C-shaped and the driving section (2) is connected between the two ends of the reaction section (1). The driving section (2) and the reaction section (1) form an annular shape, and the reaction section (1) and the driving section (2) are hollow reaction cavities. Feeding channel (3) and discharging channel (4), wherein the feeding channel (3) is connected to the top of the reaction section (1) and the discharging channel (4) is connected to the bottom of the reaction section (1) and a control valve (5) is provided on the discharging channel (4); A drive blade (6) is located inside the drive unit (2) and is used to drive the liquid in the reaction cavity to circulate. Heat exchange tube (7), the heat exchange tube (7) vertically penetrates the reaction section (1), and a plurality of heat exchange tubes (7) are vertically arranged on the reaction section (1), and a heat exchange channel is opened in the heat exchange tube (7) vertically penetrating the reaction section (1); Media introduction mechanism, all heat exchange tubes (7) are connected to the media introduction mechanism.

2. The temperature control structure of the reaction equipment according to claim 1, characterized in that, The bottom of the drive unit (2) is higher than the bottom of the reaction unit (1), the bottom of the reaction unit (1) is inclined, and the discharge channel (4) is connected to the bottom of the inner wall of the reaction unit (1).

3. The temperature control structure of a reaction apparatus according to claim 1 or 2, characterized in that, The inner wall of the drive unit (2) is vertically provided with two support frames (8), and a support rod (9) is horizontally rotatably provided between the two support frames (8). Several drive blades (6) are inclinedly provided on the outer wall of the support rod (9), and a passive bevel tooth (10) is provided at one end of the support rod (9). A drive rod (11) is provided horizontally through the drive unit (2). The drive rod (11) is rotatably connected to the drive unit (2). A drive motor (12) for driving the drive rod (11) to rotate is provided outside the drive rod (11). An active bevel tooth (13) is provided on the drive rod (11) to mesh with the passive bevel tooth (10).

4. The temperature control structure of the reaction equipment according to claim 1, characterized in that, The media inlet mechanism includes a media inlet cover (14) and a media outlet cover (15). The media inlet cover (14) is an open-facing cover, and the media outlet cover (15) is an open-facing cover. The top of the media outlet cover (15) is connected to the bottom of the reaction section (1), and the media outlet cover (15) is connected to the top of the reaction section (1). Both ends of the heat exchange channel are connected to the media inlet cover (14) and the media outlet cover (15). The bottom of the media inlet cover (14) is connected to an inlet tube (16), and an inlet pump (17) is provided on the inlet tube (16). The top of the media outlet cover (15) is connected to an outlet tube (18).

5. The temperature control structure of the reaction equipment according to claim 4, characterized in that, The media inlet cover (14) has a horizontally arranged flow equalization plate (19) on its inner wall, and a plurality of flow equalization holes (20) are opened through the flow equalization plate (19). There is a set distance between the flow equalization plate (19) and the top and bottom of the media inlet cover (14).

6. The temperature control structure of the reaction equipment according to claim 5, characterized in that, The inlet tube (16) is connected to the middle of the bottom end of the media inlet cover (14).

7. The temperature control structure of a reaction apparatus according to claim 6, characterized in that, A flow equalization frame (21) is provided at the bottom of the inner wall of the media inlet cover (14). A rotating rod (22) is vertically rotatably mounted on the flow equalization frame (21). The bottom of the rotating rod (22) is directly opposite the connection between the inlet pipe (16) and the media inlet cover (14). Several rotating plates (23) are evenly arranged in a radiating pattern on the outer wall of the rotating rod (22). The longitudinal section of the rotating plate (23) is inclined. When the fluid flows upward, the fluid can drive the rotating rod (22) to rotate through the rotating plate (23).

8. The temperature control structure of a reaction device according to claim 7, characterized in that, The top of the rotating rod (22) is provided with several arc-shaped dispersion members (24), which are used to drive fluid flow to the periphery.

9. The temperature control structure of a reaction apparatus according to claim 7, characterized in that, The top of the flow equalization frame (21) is vertically provided with a rotating cylinder (25), and the inner wall of the rotating rod (22) is movably attached to the inner wall of the rotating cylinder (25).

10. A temperature control method for progesterone production, characterized in that, Temperature control using the temperature control structure of a reaction apparatus as described in any one of claims 1-9 includes the following steps: S1, the reactants are added to the reaction section (1) in proportion through the feeding channel (3); S2, continuously inject nitrogen gas into the reaction cavity until the reaction is complete; S3, drive blade (6) to drive the fluid in the reaction cavity to circulate; S4, the heat medium flows into each heat exchange channel through the media introduction mechanism, where the temperature of the heat medium is maintained at 40-50℃.

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