Solid dispersion of pigment and / or sunscreen

Abstract

The invention relates to a solid dispersion of at least one pigment and / or of at least one sunscreen, comprising at least one pigment and / or at least one sunscreen, at least one fatty acid or fatty acid derivative, and at least one dispersant. The invention also relates to the method for preparing said dispersion, and to the uses thereof.

Description

Description Title of the invention: Solid dispersion of pigment and / or sunscreen

[0001] The invention relates to a solid dispersion of at least one pigment and / or at least one sunscreen, comprising at least one pigment and / or at least one sunscreen, at least one fatty acid or fatty acid derivative, and at least one dispersant. The invention also relates to the process for preparing said dispersion, as well as its uses. Previous Art

[0002] The present invention relates to the general technical field of substances and compounds used in the field of formulations, in particular formulations comprising pigments and / or sunscreens.

[0003] The formulation of compositions results from a mixture of different compounds to obtain a homogeneous and stable composition of these, without change over time.

[0004] Many formulations, regardless of their intended use, include pigments or sunscreens, such as zinc oxide or titanium dioxide.

[0005] These compounds are generally in solid form, and are ground into powders, in order to be incorporated into compositions.

[0006] However, the use of such compounds in powder form has several disadvantages.

[0007] The powdered form makes the storage, transport, dosing, and handling of these compounds complex, costly, messy, and polluting. These compounds also pose potential safety problems for individuals who come into contact with them.

[0008] Furthermore, grinding these pigments to obtain powders requires specialized and very expensive equipment, and the implementation of complex and lengthy processes depending on the pigments and the target particle size.

[0009] These grinding units are generally not specifically dedicated to the grinding of a pigment or sunscreen, and require adjustments to grind a compound according to other specifications, such as a different particle size, or to grind other types of compounds.

[0010] Thus, these grinding units generally produce different batches of several types and sizes of pigments or sunscreens which then need to be stored, transported and used in different composition manufacturing units.

[0011] In summary, the current practice of integrating ground pigments and sunscreens into compositions presents shortcomings in terms of ease of implementation, storage, transport, safety, and of costs.

[0012] The invention makes it possible to overcome the various disadvantages described above by offering a solid dispersion which is easily integrated into a composition, and also presents a great ease of implementation with regard to its management and in particular its transport, storage and handling. Description of the invention

[0013] According to a first aspect, the invention relates to a solid dispersion of at least one pigment and / or at least one sunscreen.

[0014] This solid dispersion comes in the form of flakes or granules.

[0015] According to one embodiment, said solid dispersion comprises between 25% and 90% by weight of said solid dispersion of said at least pigment and / or of said at least one sun filter.

[0016] According to one embodiment, said solid dispersion comprises between 50% and 90% by weight of said solid dispersion of said at least pigment and / or of said at least one sun filter.

[0017] According to one embodiment, said solid dispersion comprises between 60% and 90% by weight of said solid dispersion of said at least pigment and / or of said at least one sun filter.

[0018] According to one embodiment, said solid dispersion comprises between 70% and 90% by weight of said solid dispersion of said at least pigment and / or of said at least one sun filter.

[0019] According to one embodiment, said solid dispersion comprises between 70% and 80% by weight of said solid dispersion of said at least pigment and / or of said at least one sun filter.

[0020] According to one embodiment, said solid dispersion comprises between 75% and 80% by weight of said solid dispersion of said at least pigment and / or of said at least one sun filter.

[0021] According to one embodiment, said at least one pigment and / or said at least one sunscreen represents 25%, or 26%, or 27%, or 28%, or 29%, or 30%, or 31%, or 32%, or 33%, or 34%, or 35%, or 36%, or 37%, or 38%, or 39%, or 40%, or 41%, or 42%, or 43%, or 44%, or 45%, or 46%, or 47%, or 48%, or 49%, or 50%, or 51%, or 52%, or 53%, or 54%, or 55%, or 56%, or 57%, or 58% or 59%, or 60%, or 61%, or 62%, or 63%, or 64%, or 65%, or 66%, or 67%, or 68% or 69%, or 70%, or 71%, or 72%, or 73%, or 74%, or 75%, or 76%, or 77%, or 78% or 79%, or 80%, or 81%, or 82%, or 83%, or 84%, or 85%, or 86%, or 87%, or 88%, or 89%, or 90% by weight of said solid dispersion.

[0022] According to one embodiment, said solid dispersion also comprises at least one fatty acid or fatty acid derivative.

[0023] According to one embodiment, said solid dispersion also includes at minus one dispersant.

[0024] According to one embodiment, said solid dispersion comprises: - between 25% and 90%, preferably between 50% and 90%, even more preferably between 75% and 80%, by weight of said solid dispersion of said at least pigment and / or said at least one sunscreen; - at least one fatty acid or fatty acid derivative; - at least one dispersant.

[0025] The solid dispersion according to the invention comprises a matrix of at least one fatty acid or fatty acid derivative, within which said at least one pigment or said at least one sunscreen is dispersed, said dispersion being solid at room temperature and intended to be dispersed by preheating before being incorporated into a composition. These dispersions allow the pigments and / or sunscreens to be added to the compositions, and the remainder of the formulation consists of fatty acids or fatty acid derivatives compatible with numerous formulations.

[0026] According to one embodiment, said at least one pigment is chosen from inorganic pigments and organic pigments.

[0027] Preferably, inorganic pigments are chosen from: Cobalt Blue (Cobalt Aluminate), Ultramarine Blue (Sodium Aluminosilicate), Manganese Blue (Barium Manganate), Cerulean Blue (Cobalt Tin Oxide), Cobalt Turquoise Blue (Cobalt Chromium Oxide), Dark Cobalt Blue (Cobalt Zinc Aluminate), Dark Cobalt Blue (Cobalt Zinc Silicate), Red Iron Oxide (Synthetic Hydrated Iron Oxide), Red Ochre (Earth (Natural Iron Oxide)), True Vermilion Red (Mercury Sulfide), Cadmium Red (Cadmium Sulfoselenide), Tin Chrome Rose (Chromium Tin Oxides), Baryta Yellow (Barium Chromate), Chrome Yellow (Lead Chromate), Cadmium Yellow (Cadmium Zinc Sulfide), Yellow of Cadmium (Cadmium sulfide), Aureolin (Potassium cobalt nitrite), True Naples Yellow (Lead antimoniate), Yellow iron oxide (Synthetic anhydrous iron oxide), Yellow ochre (Earth (natural iron oxide))Nickel titanium yellow (Nickel, titanium, antimony oxides), Zinc ferrite brown (Zinc ferrite), Nickel dioxin yellow (Dioxin / nickel complex), Priderite yellow (Barium nickel titanium), Praseodymium yellow (Zirconium praseodymium oxide), Bismuth yellow (Bismuth vanadate), Mixed oxides yellow (Tin, titanium, zinc, antimony oxides), Chromium oxide green (Chromium oxide (non-hydrated)), Emerald green (Hydrated chromium oxide), True cobalt green (Cobalt and zinc oxides), Green earth (Natural earth), Chromium cobalt green (Chromium cobalt oxides), Titanium cobalt green (Cobalt and titanium oxides), Cadmium orange (Cadmium sulfoselenide), Violet Cobalt (Cobalt Phosphate), Ultramarine Violet, (Sodium Sulfur Aluminosilicate), Manganese Violet (Manganese Phosphate), Sienna (Earths (natural and burnt iron oxides)), Raw Umber (Earths (natural and burnt iron and manganese oxides)), Genuine Cassel Earth (Lignite), Titanium Chromium Yellow (Titanium, chromium, and antimony oxides), Spinel Brown (Zinc, iron, and chromium oxides), Bitumen (Gilsonite), Lamp Black (Carbon), Carbon Black (Carbon), Vine Black, Peach Black (Charcoal), Black Iron Oxide (Black Iron Oxide), Spinel Black (Copper, chromium, and manganese oxides), Silver / Lead White (Basic Lead Carbonate), Zinc White (Zinc Oxide), Lithopone White (Zinc Sulfide and Barium Sulfate), Titanium White (Titanium Dioxide), Zinc Sulfide White (Zinc Sulfide), White of chalk (calcium carbonate), titanium dioxide, and / or zinc oxide.

[0028] Preferably, said organic pigments are natural or artificial.

[0029] Preferably, the said natural organic pigments are chosen from: madder lake, dragon's blood, columbine, brazilwood, catharmine, turmeric, weld, gamboge, indigo, lichen, buckthorn, saffron, elderberry, woad, sweet potato, radish, beetroot, chlorophyll, logwood black, carrots, henna, tea, sepia, carmine (cochineal), murex, bone black, talc, clay, mica, aluminum or mother-of-pearl.

[0030] Mother-of-pearl can be composed of mica, mica and iron oxide, mica and titanium dioxide, and mica and tin oxide.

[0031] Preferably, said artificial organic pigments are selected from: Phthalo Blue (Copper Phthalocyanine), Phthalo Turquoise (Phthalocyanine), Indanthrene Blue (Indanthrone), Indigo (Synthetic Indigo), Naphthol Red (Azo (Naphthol)), Scarlet Lake (Azo (Metal Salts)), Lithol Red (Azo (Metal Salts)), Alizarin Lake (Anthraquinone Dye Lake), Thioindigo Violet (Thioindigo), Naphthol Red (Azo (Naphthol AS)), Quinacridone Rose / Magenta (Quinacridone), Peylene Red (Peiylene), Anthraquinone Red (Dibromo-anthanthrone), Anthraquinone Red (Anthraqumonic), Perylene Bordeaux (Perylene), Quinacridone Bordeaux (Quinacridone), Quinacridone Red (Quinacridone), Azo Red (Condensation Azo), Pyrazoloquinazolone Red (Pyrazoloquinazolone), DPP / Pyrole Red (Dicetopyrrolopyrrole), Hansa Yellow (Azo (Hansa)), Disazo Yellow (Azo (Disazo)), Anthraquinone Yellow (Anthrapyrimidine),Isoindolinone Yellow (Tetrachloroisoindolmone), Condensation Azo Yellow (Condensation Azo), Azomethine Yellow (Azomethine / Copper Complex), Quinophthalone Yellow (Quinophthalone), Isoindolinone Yellow (Isoindoline), Nickel Azo Yellow (Azomethine / Nickel Complex), Benzimidazolone Yellow (Azo (Benzimidazolone)), Phthalo Green (Blue Shade) (Copper Phthalocyanine), Naphthol Green (Nitroso- Green, naphthol), Phthalo Green (yellow shade) (Chlorobrominated copper phthalocyanine), Benzimidazolone Orange (Azo (benzimidazolone)), Perinone Orange (Perinone), Quinacridone Orange (Quinacridone), Quinacridone Gold (Quinacridone), Benzimidazolone Orange (Azo (benzimidazolone)), Pyrazoloquinazolone Orange (Pyrazoloquinazolone), Isoindoline Orange (Isoindoline), DPP / Pyrole Orange (Diketopyrrolopyrrole), Quinacridone Magenta / Violet (Quinacridone gamma), Dioxazine Violet (Dioxazine carboazole), Perylene Violet (Perylene), Quinacridone Pink (Quinacridone), Condensation Azo Brown (Condensation Azo), Benzimidazolone Brown (Azo (benzimidazolone)), Azo Brown (Disazoic condensation), Aniline black (Indamine), Perylene black (Perylene).

[0032] According to one embodiment, said at least one pigment is coated with polyhydroxystearic acid, or silica and jojoba esters, or alumina and jojoba esters, or stearic acid, or jojoba esters.

[0033] According to one embodiment, said at least one sunscreen is selected from: camphor benzalkonium methosulfate, homosalate, benzophenone-3 (oxybenzone, bp-3, bz-3), phenylbenzimidazole sulfonic acid (ensulizole), terephthalylidene dicamphor sulfonic acid (ecamsul or meroxyl sx), butyl methoxydibenzozoylmethane (avobenzone), benzylidene camphor sulfonic acid, octocrylene, polyacrylamidomethyl benzylidene camphor, ethylhexyl methoxycinnamate (octinoxate), PEG 25-PABA, isoamyl p-methoxy cinnamate, ethylhexyl triazone (octyl triazone), drometrizole trisiloxane (meroxyl xl), diethylhexyl butamido triazone, camphor 4-Methylbenzylidene (4-MBC), ethylhexyl salicylate or octyl salicylate (octisalate), ethylhexyl dimethyl PABA or octyl dimethyl PABA (padimate o), benzophenone-4, benzophenone-5 or sulisobenzone, methylene bis-benzotriazolyl tetramethylbutylphenol (Trinosorb m), disodium phenyl dibenzimidazole tetrasulfonate,bis-ethylhexyloxyphenol methoxyphenyl triazine (trinosorb, bemotrizinol), polysilicone-15, and / or hexyl diethylamino hydroxybenzoyl benzoate..,

[0034] According to one embodiment, said solid dispersion comprises between 2% and 25% by weight of said solid dispersion of at least one fatty acid or fatty acid derivative, preferably between 5% and 20%, even more preferably between 7% and 15%.

[0035] According to one embodiment, said at least one fatty acid or fatty acid derivative represents 2%, or 2.5%, or 3%, or 3.5%, or 4%, or 4.5%, or 5%, or 5.5%, or 6%, or 6.5%, or 7%, or 7.5%, or 8%, or 8.5%, or 9%, or 9.5%, or 10%, or 10.5%, or 11%, or 11.5%, or 12%, or 12.5%, or 13%, or 13.5%, or 14%, or 14.5%, or 15%, or 15.5%, or 16%, or 16.5%, or 17%, or 17.5%, or 18%, or 18.5%, or 19%, or 19.5%, or 20%, or 20.5%, or 21%, or 21.5%, or 22%, or 22.5%, or 23%, or 23.5%, or 24%, or 24.5%, or 25% by weight of said solid dispersion.

[0036] According to one embodiment, said at least one fatty acid or fatty acid derivative is chosen from fatty acids, fatty acid esters, fatty alcohols, fatty acid derivatives isolated from natural raw materials, and natural raw materials which contain fatty acids, preferably chosen from butters and waxes.

[0037] According to one embodiment, said at least one fatty acid or fatty acid derivative is at least one wax, selected from: Candelilla wax, Carnauba wax, rice wax, flower waxes, beeswax, sunflower wax, and / or jojoba wax.

[0038] Preferably, flower waxes are chosen from: rose wax, jasmine wax, mimosa wax, tuberose wax, orange blossom wax, acacia wax, lavender wax, lotus wax, or yang-yang wax.

[0039] According to one embodiment, said at least one fatty acid is chosen from: lauric acid, myristic acid, palmitic acid, stearic acid, arachidic acid, behenic acid, lignoceric acid, and / or hydroxystearic acid.

[0040] According to one embodiment, said at least one fatty acid or fatty acid derivative is chosen from candelilla wax and / or sunflower seed wax and / or palmitic acid.

[0041] According to one embodiment, said solid dispersion comprises between 2% and 25% by weight of said solid dispersion of candelilla wax and / or sunflower seed wax and / or palmitic acid, preferably between 5% and 20%, even more preferably between 7% and 15%.

[0042] According to one embodiment, said solid dispersion comprises 4.5% or 5% by weight of said solid dispersion of candelilla wax.

[0043] According to one embodiment, said solid dispersion comprises 4.5% or 5% by weight of said solid dispersion of sunflower seed wax.

[0044] According to one embodiment, said solid dispersion comprises 4.5% or 5% by weight of said solid dispersion of candelilla wax and 4.5% or 5% by weight of said solid dispersion of sunflower seed wax.

[0045] According to one embodiment, said solid dispersion comprises 2.5% by weight of said solid dispersion of palmitic acid.

[0046] According to one embodiment, said solid dispersion comprises 2.5% by weight of said solid dispersion of palmitic acid and 4.5% or 5% by weight of said solid dispersion of sunflower seed wax.

[0047] According to one embodiment, said solid dispersion comprises between 5% and 40% by weight of said solid dispersion of at least one dispersant, preferably between 8% and 35%.

[0048] According to one embodiment, said at least one dispersant represents 5%, or 6%, or 7%, or 8%, or 9%, or 10%, or 11%, or 12%, or 13%, or 14%, or 15%, or 16%, or 17%, or 18%, or 19%, or 20%, or 21%, or 22%, or 23%, or 24%, or 25%, or 26%, or 27%, or 28%, or 29%, or 30%, or 31%, or 32%, or 33%, or 34%, or 35%, or 36%, or 37%, or 38%, or 39%, or 40% by weight of said solid dispersion.

[0049] According to one embodiment, said at least one dispersant is selected from: polyglyceryl-3 polyrinoleate, polyhydroxystearic acid, pentylene glycol, cetyl dimethicone, cyclopentasiloxane, silica, stearic acid, PVP, maltodextrin, benzalkonium chloride, PEG-18 castor oil dioleate, PEG-80 sorbitan laurate, polysorbate 20, polysorbate 60, polysorbate 80, PEG-5 cocamide, lauroyl lysine, caprylic / capric triglyceride, isostearic acid, lecithin, caprylyl glycol, acrylates copolymer, polyglyceryl-3 diisostearate, polyglyceryl-4 isostearate, polyglyceryl-6 polyrinoleate, lecithin, isopropyl myristate, Cl 2- 15 alkyl benzoate, decyl glucoside, lauryl glucoside, sucrose stearate, sorbitan stearate, glyceryl stearate, glyceryl oleate, stearyl alcohol, or oils selected from jojoba oil, sunflower oil, olive oil, almond oil or argan oil.

[0050] According to one embodiment, said at least one dispersant is polyglyceryl-3 polyricinoleate or polyhydroxystearic acid.

[0051] Preferably, said solid dispersion comprises between 5% and 25% by weight of said solid dispersion of polyglyceryl-3 polyricinoleate, preferably between 8% and 20%, even more preferably between 11% and 15%.

[0052] Preferably, said solid dispersion comprises 11% or 15% by weight of said solid dispersion of polyglyceryl-3 polyricinoleate.

[0053] Preferably, said solid dispersion comprises between 5% and 25% by weight of said solid dispersion of polyhydroxystearic acid, preferably between 8% and 20%, even more preferably between 11% and 15%.

[0054] Preferably, said solid dispersion comprises 11% or 15% by weight of said solid dispersion of polyhydroxystearic acid.

[0055] According to one embodiment, said solid dispersion comprises: - Candelilla wax; - Sunflower seed wax; - Polyglyceryl-3 polyricinoleate.

[0056] According to one embodiment, said solid dispersion comprises: - Palmitic acid; - Sunflower seed wax; - Polyglyceryl-3 polyricinoleate.

[0057] According to one embodiment, said solid dispersion comprises: - Palmitic acid; - Sunflower seed wax; - Polyhydroxystearic acid.

[0058] According to one embodiment, said solid dispersion comprises: - Palmitic acid; - Rice wax; - Camauba wax.

[0059] According to one embodiment, said at least one pigment is chosen from zinc oxide and / or titanium dioxide and / or red iron oxide.

[0060] According to one embodiment, said solid dispersion consists of: - between 25% and 90%, preferably between 50% and 90%, even more preferably between 75% and 80%, by weight of said solid dispersion of said at least pigment and / or said at least one sunscreen; - at least one fatty acid or fatty acid derivative; - at least one dispersant.

[0061] According to one embodiment, said solid dispersion consists of: - Candelilla wax; - Sunflower seed wax; - Polyglyceiyl-3 Polyricinoleate; - between 75% and 80% by weight of said solid dispersion of zinc oxide and / or titanium dioxide.

[0062] According to one embodiment, said solid dispersion consists of: - Palmitic acid; - Sunflower seed wax; - Polyglyceiyl-3 polyricinoleate - between 75% and 80% by weight of said solid dispersion of zinc oxide and / or titanium dioxide.

[0063] According to one embodiment, said solid dispersion comprises or consists of the following formulation: [Table 1]

[0064] According to another embodiment, said solid dispersion comprises or consists of the following formulation: [Table 2]

[0065] According to another embodiment, said solid dispersion comprises or consists of the following formulation: [Table 3]

[0066] According to another embodiment, said solid dispersion comprises or consists of the following formulation: [Table 4]

[0067] According to another embodiment, said solid dispersion comprises or consists of the following formulation: [Table 5]

[0068] According to another aspect, the invention relates to a process for preparing a solid dispersion comprising the steps of: i. Mixing said at least one fatty acid or fatty acid derivative and said at least one dispersant, under stirring between 200 and 800 rpm, and heating between 65°C and 90°C, preferably 75°C; ii. Once the mixture obtained in step i. has been homogenized, progressive addition of at least one pigment and / or at least one sunscreen, under stirring between 800 and 2000 rpm; iii. Stirring the mixture obtained in step ii. between 800 and 2000 rpm for at least 10 minutes; iv. Stopping the stirring of the mixture obtained in step iii. and forming the solid dispersion, preferably by hot extrusion between 65°C and 90°C, preferably 75°C.

[0069] Preferably, in step iv., hot extrusion allows the formation of glitter.

[0070] Preferably, said at least one pigment and / or at least one sunscreen added in step ii. is in powder form.

[0071] The solid dispersions of "Table 1" and "Table 2" are obtained with the following process: i. Mixing candelilla wax, sunflower seed wax, and polyglyceryl-3 polyricinoleate, under stirring between 200 and 800 rpm and heating to 75 °C; ii. Once the mixture obtained in step i. is homogenized, progressive addition of zinc oxide, under stirring between 800 and 2000 rpm; iii. Stirring of the mixture obtained in step ii. at 1200 rpm for at least 10 minutes; iv. Stopping stirring of the mixture obtained in step iii. and forming the solid dispersion, by hot extrusion at 75 °C, to form flakes.

[0072] Said dispersion is solid at room temperature and intended to be dispersed by heating and preferably used within a cosmetic and / or dermatological composition to incorporate said at least one pigment and / or said at least one sunscreen.

[0073] According to another aspect, the invention relates to another method for preparing a solid dispersion according to the invention, comprising the steps of: i. Mixing at least a portion of all of said at least one pigment and / or at least one sunscreen in said at least one dispersant, under stirring between 800 and 2000 rpm; ii. Once the mixture obtained in step i. has been homogenized, adding said at least one fatty acid or a fatty acid derivative under stirring between 800 and 2000 rpm and heating between 65°C and 90°C, preferably 75°C; iii. Optionally, if in step i. all of said at least one pigment and / or at least one sunscreen have not been added, once the mixture obtained in step ii. has been homogenized, progressively adding the remainder of said at least one pigment and / or at least one sunscreen, under stirring between 800 and 2000 rpm; iv. Stop stirring the mixture obtained in step ii. or in step iii.and formation of the solid dispersion, by hot extrusion between 65°C and 90°C, preferably 75°C.

[0074] Preferably, in step iv., hot extrusion allows the formation of glitter.

[0075] According to one embodiment, in step i, at least a portion of all at least one pigment and / or at least one sunscreen represents between 50% and 100% of all at least one pigment and / or at least one sunscreen in the total composition. Step iii is therefore optional and is only present if all at least one pigment and / or at least one sunscreen is not added in step i.

[0076] In all the solid dispersion preparation processes according to the invention, the extrusion step can be followed by a step of reducing the resulting flakes into granules, for example by passing the flakes through a granulator. An example of such a granule is shown in Figure 7.

[0077] According to another aspect, the invention relates to another method for preparing a solid dispersion according to the invention, comprising the steps, in an extrusion column, of: - Introduction of said at least one fatty acid or fatty acid derivative into the extrusion column; - Introduction of said at least one pigment and / or at least one solar filter into the extrusion column; - Introduction of said at least one dispersant into the extrusion column; these introduction steps being carried out at different locations within said extrusion column; these process steps being followed by steps comprising: i. Mixing of said at least one fatty acid or fatty acid derivative, said at least one pigment and / or at least one sunscreen, and said at least a dispersant in the extrusion column, at between 50°C and 80°C, preferably between 60° and 70°C; even more preferably 65°C; ii. Extrusion by the column of the solid dispersion, in the form of flakes; iii. Optionally, reduction of the flakes into granules, preferably by means of a granulator.

[0078] According to one embodiment, step ii. of extrusion by the extrusion column of the solid dispersion, in the form of flakes, is carried out at a flow rate of between 0.5 kg / hour and 2.5 kg / hour, preferably between 1 kg / hour and 2 kg / hour.

[0079] According to another aspect, the invention relates to the use of a solid dispersion according to the invention, to introduce at least one pigment and / or at least one sunscreen into a cosmetic and / or dermatological composition.

[0080] According to another aspect, the invention relates to the use of a solid dispersion according to the invention, to introduce at least one pigment and / or at least one sunscreen into a composition.

[0081] According to another aspect, the invention relates to a method for formulating a cosmetic and / or dermatological composition comprising at least one pigment and / or at least one sunscreen, comprising a step of heating a solid dispersion according to the invention, followed by a step of mixing said dispersion with the other compounds of the cosmetic and / or dermatological formulation.

[0082] According to another aspect, the invention relates to a non-therapeutic cosmetic composition for healthy subjects, comprising a dispersion according to the invention.

[0083] According to another aspect, the invention relates to a composition for dermatological use, comprising a dispersion according to the invention.

[0084] Cosmetic compositions into which said solid dispersion may be introduced may include any cosmetically acceptable ingredient.

[0085] These cosmetic compositions may also include surfactants, complexing agents, preservatives, stabilizing agents, emulsifiers, thickeners, gelling agents, humectants, emollients, trace elements, essential oils, perfumes, colorants, mattifying agents, chemical or mineral filters, moisturizing agents, thermal waters, etc.

[0086] Dermatological compositions into which said solid dispersion may be introduced may include any dermatologically acceptable ingredient.

[0087] These dermatological compositions may also include humectants, emollients, occlusives, exfoliants, antioxidants, anti-inflammatory agents, brightening agents, peptides, retinoids, therapeutic actives (anti-acne for example).

[0088] Cosmetic and / or dermatological compositions using dispersions solids according to the invention may be presented in the forms usually known for topical administration, that is to say in particular lotions, milks, emulsions, serums, balms, masks, creams, dispersions, gels, foams or sprays.

[0089] According to another aspect, the invention relates to the use of a solid dispersion according to the invention, to introduce at least one pigment and / or at least one solar filter into a protective composition and / or interior and / or exterior surface coating.

[0090] According to another aspect, the invention relates to a method for formulating a protective composition and / or interior and / or exterior surface coating comprising at least one pigment and / or at least one solar filter, comprising a step of heating a solid dispersion according to the invention, followed by a step of mixing said dispersion with the other compounds of the formulation.

[0091] Preferably, said interior and / or exterior surface protection and / or coating composition is a composition of paint, resin, varnish, coating, maintenance product, repair product, surface treatment or plaster.

[0092] Preferably, said protective and / or interior coating composition and / or also includes polymers, solvents, bonding agents, and / or specific additives (such as anti-mold agents, hardening agents, waterproofing agents).

[0093] In another aspect, the invention relates to a method for formulating a composition comprising at least one pigment and / or at least one sunscreen, comprising a step of heating a solid dispersion according to the invention, followed by a step of mixing said dispersion with the other compounds

[0094] According to one embodiment, the formulation is a cosmetic and / or dermatological formulation.

[0095] According to one embodiment, the formulation is a formulation for protecting and / or coating interior and / or exterior surfaces, preferably paint, resin, varnish, coating, maintenance product, repair product, surface treatment product or plaster.

[0096] Paints, resins, varnishes, coatings, maintenance products, repair compositions, surface treatment compositions or plasters can be formulated in the form of oil, wax or paste.

[0097] The solid dispersions according to the invention have the following advantages compared to other dispersions (in powder or liquid form): - to be easier to handle; - to drastically reduce the constraints of handling in production related to operator safety; - to be stable over time without risk of oxidation degradation; - to avoid any risk of separation in storage containers due to density differences between powders and the liquid medium; - to guarantee the percentage of powder of the compounds present in the quantity taken from the container for production, which is complicated when using a liquid dispersion due to variations in density, storage time and therefore overall homogeneity.

[0098] These solid dispersions are simple and inexpensive, easy to handle and store, easy to incorporate into cosmetic and / or dermatological compositions, have good repeatability as a component for the formulation of cosmetic and / or dermatological compositions, and implement a minimal number of different substances, making it a dispersion that degrades very little or not at all over time. Figures

[0099] [Fig 1] is a microscopic observation of the emulsion with the solid dispersion according to the invention of zinc oxide, coated with polyhydroxystearic acid.

[0100] [Fig 2] is a microscopic observation of the emulsion with the solid dispersion according to the invention of uncoated zinc oxide.

[0101] [Fig 3] is a microscopic observation of the zinc oxide emulsion coated with polyhydroxystearic acid, without the solid dispersion according to the invention.

[0102] [Fig 4] is a microscopic observation of the uncoated zinc oxide emulsion, without the solid dispersion according to the invention.

[0103] [Fig 5] is a naked-eye observation of the red iron oxide dispersion as obtained in example 3, in the form of "flakes".

[0104] [Fig 6] is a microscopic observation of the mixture of red iron oxide in the solid dispersion obtained in Example 3, redispersed in sunflower oil.

[0105] [Fig 7] is a naked-eye observation of granules obtained by means of the methods according to the invention, comprising a step of passing through a granulator, with a dispersion of zinc oxide. Definitions

[0106] For the purposes of this invention, "solid dispersion" means a formulation in which an active ingredient, pigment or sunscreen within the scope of the invention, soluble or in the form of particles, is dispersed at the molecular level homogeneously in a solid matrix, comprising within the scope of the invention preferably at least one fatty acid or fatty acid derivative and at least one dispersant.

[0107] For the purposes of this invention, "solid" means that the dispersion is in a non-liquid form, such as bars or sticks. This solid dispersion is not in powder form.

[0108] For the purposes of this invention, "pigment" means an insoluble substance used Used to color cosmetic and / or dermatological compositions. They can be inorganic (mineral) or organic (chemical), and can also provide additional properties such as sun protection.

[0109] Inorganic pigments are colorants composed primarily of minerals or metallic compounds such as oxides, sulfides, or metal salts. Unlike organic pigments, they do not contain complex carbon compounds.

[0110] Organic pigments are dyes composed mainly of carbon-based organic compounds, and which may include atoms of carbon, hydrogen, oxygen, nitrogen and other elements.

[0111] Natural pigments are coloring substances derived primarily from organic or mineral sources found in nature. They are extracted from or derived from natural raw materials such as plants, minerals, animals, or other organisms. Natural pigments can include a variety of organic or inorganic chemical compounds that produce specific colors, often depending on their molecular or mineral structure.

[0112] Artificial pigments are synthetic chemical substances created specifically for use as colorants. They are produced in the laboratory through controlled chemical processes.

[0113] Zinc oxide is an inorganic compound primarily used as a pigment, particularly in cosmetic and / or dermatological formulations. In cosmetics, it is also used as a sunscreen, providing protection against UVA and UVB rays.

[0114] Titanium dioxide is an inorganic compound primarily used as a pigment, particularly in cosmetic and / or dermatological formulations. In cosmetics, it is also used as a UV filter in sunscreens to protect the skin against UVA and UVB rays.

[0115] For the purposes of this invention, "sunscreen" refers to a substance that protects the skin against the sun's ultraviolet (UV) rays. Used in sunscreens, it absorbs, reflects, or scatters UV rays, thereby reducing the risk of sunburn and long-term skin damage.

[0116] Certain compounds, such as zinc oxide and titanium dioxide, are considered both pigments and sunscreens. In the context of this invention, they are included within the pigments.

[0117] "Polyhydroxystearic acid coating" is a process in which pigments are coated with a layer of polyhydroxystearic acid, a fatty acid derivative. This technique improves the dispersion and stability of particles in formulations. Polyhydroxystearic acid acts as an emulsifying and stabilizing agent, helping to prevent the aggregation of particles and ensure uniform distribution in the final product. This helps improve the performance and appearance of cosmetic products

[0118] A "fatty acid" is an organic molecule composed of a hydrocarbon chain of varying length and a carboxyl group (-COOH) at one end. They are classified as saturated fatty acids (without double bonds) and unsaturated fatty acids (with one or more double bonds).

[0119] A fatty acid derivative is a substance obtained by chemically modifying a fatty acid. These modifications can include hydrogenation, esterification, or the formation of amides and peroxides. Fatty acid derivatives include compounds such as fatty acid esters and trans fatty acids.

[0120] A fatty acid ester is a chemical compound formed by the reaction between a fatty acid and an alcohol, releasing a water molecule. Fatty acid esters occur naturally in fats such as triglycerides, where three fatty acids are linked to glycerol.

[0121] A "fatty alcohol" is a long-chain alcohol, generally composed of 8 to 22 carbon atoms. These alcohols, derived from fatty acids, are in solid or liquid form at room temperature, depending on the length of the carbon chain.

[0122] "Derivatives of fatty acids isolated from natural raw materials" are compounds obtained by chemical or physical modification of fatty acids extracted from natural sources such as animal fats or algae. These derivatives include esters, fatty alcohols, amides, and peroxides. They are of natural origin and undergo environmentally friendly processing.

[0123] "Natural raw materials containing fatty acids" are substances of plant, animal, or marine origin rich in fatty acids. These sources include animal fats and seaweed. They are used to extract essential fatty acids for various industrial applications.

[0124] "Candelilla wax" is a natural product extracted from the leaves of the Euphorbia cerifera plant. It consists mainly of long-chain esters.

[0125] Sunflower seed wax, also known as "Helianthus annuus" wax, is a natural product extracted from sunflower seeds. This vegetable wax is rich in fatty acids and vitamin E. The sunflower wax used in the dispersions according to the invention is preferably produced by hydrogenating sunflower oil. Hydrogenation involves adding two hydrogen atoms to the chemical formula of vegetable oils containing polyunsaturated fats. This process solidifies the oils, allowing them to be stored for longer periods without becoming rancid.

[0126] Palmitic acid is a 16-carbon saturated fatty acid commonly found in animal and vegetable fats. It is a major component of oil. palm and cocoa butter.

[0127] A dispersant is a substance used to improve the uniform distribution of solid particles in a liquid, preventing them from clumping and settling. A dispersant works by reducing the attractive forces between the particles, allowing for a homogeneous suspension.

[0128] "Polyglyceryl-3 polyricinoleate" is a compound of plant origin, derived from natural fatty acids and glyceryl ricinoleate. This compound facilitates the uniform dispersion of the ingredients in the dispersion according to the invention.

[0129] "Polyhydroxystearic acid" is an organic compound derived from stearic acid, modified to contain several hydroxyl groups (-OH). This compound facilitates the uniform dispersion of the ingredients in the dispersion according to the invention.

[0130] A "cosmetic composition" is a specific formulation designed to be applied to the skin, hair, or nails to improve their appearance or texture. It is a non-therapeutic composition for a healthy individual and is not intended to treat a patient.

[0131] A "dermatological composition" is a therapeutic formulation specifically designed for skincare, developed to address specific needs such as hydration, sun protection, anti-aging, or the treatment of skin conditions like acne or eczema. These compositions include ingredients with proven therapeutic effects, such as moisturizing agents, antioxidants, exfoliating acids, vitamins, and dermatological medications.

[0132] By "glitter", or "sticks", or "sticks" is meant the form of the solid dispersion according to the invention, presented in linear elongated form.

[0133] The term "granules" refers to small, agglomerated solid particles with a controlled shape, size, and density to facilitate handling, transport, or subsequent use. They can be produced by a granulator.

[0134] For the purposes of this invention, "cosmetically acceptable" means a substance useful in the preparation of a cosmetic composition, which is generally safe, non-toxic and neither biologically nor otherwise undesirable, and which is acceptable for cosmetic use, in particular by topical application to the skin.

[0135] For the purposes of this invention, "dermatologically acceptable" means a substance approved for its safety and skin tolerance. It therefore does not cause irritation, allergies, or sensitization. This type of substance also includes those that provide a demonstrated dermatological therapeutic effect.

[0136] For the purposes of this invention, "protective composition and / or interior and / or exterior surface coatings" means formulations intended for These compositions protect and / or beautify the interior and exterior surfaces of buildings to which they are applied. These surfaces may include, but are not limited to: wood, brick, concrete, glass, steel, stone, stucco, aluminum, vinyl, fiber cement, terracotta, composite materials, slate, granite, marble, tile, zinc, copper, and PVC. The composition itself may include paint, resin, varnish, coating, or plaster. In addition to the compounds present in the dispersions according to the invention, these compositions may also include polymers, solvents, bonding agents, specific additives (such as mold inhibitors, hardening agents, and waterproofing agents), and other ingredients depending on the properties required for the final product.

[0137] The term "extrusion column" means a vertical or substantially vertical device intended to allow the controlled extrusion of a material under the effect of applied pressure or thrust, typically by means of a piston, screw or feeding system, said column comprising a material containment conduit, at least one compression zone, and an extrusion outlet configured to deliver the extraded material according to a predetermined geometry.

[0138] In the description and the following examples, unless otherwise stated, percentages are percentages by weight, and value ranges expressed as "between ... and ..." include the specified lower and upper bounds. The examples below are provided for illustrative purposes only and are not intended to limit the scope of the invention. Examples

[0139] Example 1: Formulations according to the invention

[0140] Two Zinc Oxide Dispersions were carried out: - 1 - With Zinc Oxide coated Polyhydroxystearic Acid (table 6) - 2 - With uncoated Zinc Oxide (table 7)

[0141] First formulation [Table 6]

[0142] Second formulation [Table 7]

[0143] These formulations are obtained as follows: i. Mixing Candelilla Wax, Sunflower Seed Wax, and Polyglyceryl-3 Polyricinoleate, under agitation between 200 and 800 rpm and heating to 75 °C; ii. Once the mixture obtained in step i. is homogenized, progressive addition of zinc oxide, under agitation between 800 and 2000 rpm; iii. Agitation of the mixture obtained in step ii. at 1200 rpm for at least 10 minutes; iv. Stopping agitation of the mixture obtained in step iii. and formation of the solid dispersion, by hot extrusion at 75 °C, to form flakes.

[0144] Example 2: Use of the formulations according to the invention

[0145] Solid dispersions according to example 1 were used and emulsified to verify the proper dispersion of zinc oxide once formulated.

[0146] Emulsions are also made with the same ingredients in the same quantity without going through the solid dispersion according to the invention, in order to compare the results.

[0147] Formulations and protocols

[0148] The emulsions are formulated to contain 24% zinc oxide.

[0149] Emulsions with solid dispersions

[0150] Emulsion of solid dispersion of zinc oxide coated with polyhydroxystearic acid (Table 6). [Table 8]

[0151] Emulsion of uncoated zinc oxide solid dispersion (Table 7). [Table 9]

[0152] The formulations were obtained through the following steps: - Heat the water and EDTA in a bain-marie to 75°C. While stirring, add the Xanthan gum previously mixed in glycerin (Phase 1 in tables 8 and 9). - Mix the ingredients of the 2 eme phase (Phase 2 in tables 8 and 9), and heat in a water bath at 75°C. - When phases 1 and 2 are at 75°C, pour phase 2 into phase 1, while stirring. - Cool the emulsion obtained to T<40°C and add phase 3 (Phase 3 in tables 8 and 9).

[0153] Emulsions without solid dispersions according to the invention

[0154] Zinc oxide emulsion coated with polyhydroxystearic acid.

[0155] [Table 10]

[0156] Uncoated zinc oxide emulsion.

[0157] [Table 11]

[0158] The formulations were obtained through the following steps: - Heat the water and EDTA in a bain-marie to 75°C. While stirring, add the Xanthan gum previously mixed in glycerin (Phase 1 in tables 10 and 11). - Mix the ingredients of the 2 eme phase (Phase 2 in tables 10 and 11) without zinc oxide, and heat in a water bath at 75°C. - Once homogenized, introduce the zinc oxide, under vigorous stirring. - When phases 1 and 2 are at 75°C, pour phase 2 into phase 1, while stirring. - Cool the resulting emulsion to T<40°C and add phase 3 (Phase 3 in tables 10 and 11).

[0159] Results

[0160] Microscopic observations of the diluted emulsions obtained are carried out; the images can be found in figures 1 to 4.

[0161] In all cases, zinc oxide appears to be well dispersed, the differences observed being due to the dilution of the emulsions.

[0162] The solid dispersions according to the invention therefore allow as good a dispersion after formulation (here in emulsion) as the addition of the compounds without going through the solid dispersions according to the invention.

[0163] Example 3: Formulation according to the invention - Red iron oxide

[0164] A dispersion of red iron oxide was carried out (table 12).

[0165] [Table 12]

[0166] This formulation is obtained as follows, in an extrusion column, through the following steps: - Introduction of rice wax, palmitic acid and camauba wax into the extrusion column; - Introduction of red iron oxide into the extrusion column; - Introduction of polyhydroxystearic acid into the extrusion column; these steps being carried out at different locations in said extrusion column; these steps being followed by the steps of: i. Mixing of rice wax, palmitic acid, camauba wax, red iron oxide and polyhydroxystearic acid in the extrusion column, at 65°C; ii. Extrusion by the column of the solid dispersion, in the form of flakes, at a flow rate of between 1 kg / hour and 2 kg / hour.

[0167] The glitter obtained in step ii. has a shape as shown in figure 5.

[0168] Example 4: Use of the formulation according to the invention

[0169] The solid dispersion according to example 3 was used and redispersed in sunflower oil, in order to verify the good dispersion of the red iron oxide once put into formulation.

[0170] The dispersion / sunflower oil ratio was 25% dispersion to 75% sunflower oil.

[0171] Results

[0172] Microscopic observations were carried out. Figure 6 shows a photograph of a microscopic observation of the mixture of red iron oxide in the solid dispersion obtained in example 3, redispersed in sunflower oil.

[0173] The red iron oxide appears to be well dispersed.

[0174] These elements confirm that the solid dispersions according to the invention therefore allow for dispersion as good after formulation (here in sunflower oil) as the addition of the compounds without using dispersions. solids according to the invention.

Claims

Demands

1. Solid dispersion of at least one pigment and / or at least one sunscreen comprising: - between 25% and 90%, preferably between 50% and 90%, even more preferably between 75% and 80%, by weight of said solid dispersion of said at least pigment and / or said at least one sunscreen; - at least one fatty acid or fatty acid derivative; - at least one dispersant.

2. Solid dispersion according to the preceding claim, wherein said at least one pigment is selected from inorganic pigments and organic pigments.

3. Solid dispersion according to any one of the preceding claims, wherein said at least one sunscreen filter is selected from: camphor benzalkonium methosulfate, homosalate, benzophenone-3, phenylbenzimidazole sulfonic acid, terephthalylidene dicamphor sulfonic acid, butyl methoxydibenzoylmethane, benzylidene camphor sulfonic acid, octocrylene, polyacrylamidomethyl benzylidene camphor, ethylhexyl methoxycinnamate, PEG-25-PABA, isoamyl p-methoxy cinnamate, ethylhexyl triazone, drometrizole trisiloxane, diethylhexyl butamido triazone, camphor 4-methylbenzylidene (4-MBC), ethylhexyl salicylate or octyl salicylate (octisalate), dimethyl PABA ethylhexyl or dimethyl octyl paba (padimate o), benzophenone-4, benzophenone-5 or sulisobenzone, methylene bis-benzotriazolyl tetramethylbutylphenol (trinosorb m), disodium phenyl dibenzimidazole tetrasulfonate, bis-ethylhexyloxyphenol methoxyphenyl triazole (trinosorb, bemotrizinol),polysilicone-15, and / or hexyl diethylamino hydroxybenzoyl benzoate.

4. Solid dispersion according to any one of the preceding claims, including: - between 2% and 25% by weight of said solid dispersion of at least one fatty acid or fatty acid derivative, preferably between 5% and 20%, even more preferably between 7% and 15%; and - between 5% and 40% by weight of said solid dispersion of at least one dispersant, preferably between 8% and 35%.

5. Solid dispersion according to any one of the preceding claims, wherein said at least one pigment is selected from: zinc oxide and / or titanium dioxide and / or red iron oxide.

6. Solid dispersion according to any one of the preceding claims, wherein said at least one fatty acid or fatty acid derivative is selected from fatty acids, fatty acid esters, fatty alcohols, fatty acid derivatives isolated from natural raw materials, and natural raw materials which contain fatty acids, preferably selected from butters or waxes.

7. Solid dispersion according to any one of the preceding claims, where: - said at least one fatty acid or fatty acid derivative is candelilla wax and / or sunflower seed wax and / or rice wax and / or carnauba wax and / or palmitic acid; and / or - said at least one dispersant is polyglyceryl-3 polyricinoleate or polyhydroxystearic acid.

8. A method for preparing a solid dispersion according to any one of the preceding claims, comprising the steps of: i. Mixing said at least one fatty acid or fatty acid derivative and said at least one dispersant, under stirring between 200 and 800 rpm, and heating between 65°C and 90°C, preferably 75°C; ii. Once the mixture obtained in step i. has been homogenized, progressively adding at least one pigment and / or at least one sunscreen, under stirring between 800 and 2000 rpm; iii. Stirring the mixture obtained in step ii. between 800 and 2000 rpm for at least 10 minutes; iv. Stopping stirring of the mixture obtained in step iii. and forming the solid dispersion, preferably by hot extrusion between 65°C and 90°C, preferably 75°C, to form flakes.

9. Use of a solid dispersion according to any one of claims 1 to 7, to introduce at least one pigment and / or at least one sunscreen into a cosmetic and / or dermatological composition.

10. Use of a solid dispersion according to any one of claims 1 to 7, for introducing at least one pigment and / or to less a solar filter in a protective composition and / or interior and / or exterior surface coating.

Images