Composition for suppressing decrease in thickness of collagen fiber bundle due to UVA irradiation

Abstract

The purpose of this disclosure is to find a novel function of an ergothioneine compound, and to provide a preparation using this function.　One embodiment of this disclosure is a composition for suppressing a decrease in the thickness of a collagen fiber bundle due to UVA irradiation, the composition containing an ergothioneine compound as an active ingredient.

Description

Composition for inhibiting reduction in collagen fiber bundle thickness due to UVA irradiation

[0001] The present disclosure relates to a composition for inhibiting the reduction in thickness of collagen fiber bundles due to UVA irradiation.

[0002] Ergothioneine (sometimes referred to as "EGT" in this specification) is a type of sulfur-containing amino acid, and is known to have a variety of physiological activities including antioxidant activity.

[0003] For example, Patent Document 1 discloses a skin-whitening cosmetic composition characterized by blending ergothioneine in a cosmetic base, and reports that ergothioneine has a skin-whitening effect.

[0004] Patent Document 2 discloses the use of ergothioneine and / or a derivative thereof as an agent for reducing the glycation of skin proteins in a cosmetic composition, and reports that ergothioneine has the effect of reducing the glycation of skin proteins.

[0005] Patent Document 3 discloses an ATP production promoter characterized by containing ergothioneine as an active ingredient, and reports that ergothioneine has an ATP production promoting effect.

[0006] Japanese Patent Application Laid-Open No. 48-44442 Japanese Patent Application Laid-Open No. 2002-37724 Japanese Patent Application Laid-Open No. 2003-231626

[0007] As described in Patent Documents 1 to 3, various research results have already been reported regarding cosmetics using ergothioneine compounds such as ergothioneine, but the discovery of further functions has been anticipated.

[0008] Therefore, an object of the present disclosure is to discover a novel function of ergothioneine compounds and to provide a composition that utilizes this function.

[0009] In order to achieve the above-mentioned object, the present inventors have conducted research into the functions of ergothioneine compounds and have found that ergothioneine compounds are effective in inhibiting the reduction in thickness of collagen fiber bundles caused by UVA irradiation, leading to the present disclosure.

[0010] Therefore, an example of the present embodiment is as follows.

[0011] (1) A composition for inhibiting a decrease in the thickness of collagen fiber bundles due to UVA irradiation, comprising an ergothioneine compound as an active ingredient. (2) The composition according to (1), for inhibiting a decrease in the thickness of collagen fiber bundles in the dermis due to UVA irradiation. (3) The composition according to (1) or (2), which is an external preparation for skin.

[0012] The present disclosure makes it possible to discover a novel function of ergothioneine compounds and to provide a composition that utilizes this function.

[0013] 1 is a representative topographical image of a test sample (dermis) obtained in Reference Example 1, obtained using an atomic force microscope (AFM). 2 is a representative topographical image of a test sample (dermis) obtained in Reference Example 2, obtained using an atomic force microscope (AFM). 3 is a representative topographical image of a test sample (dermis) obtained in Experimental Example 1, obtained using an atomic force microscope (AFM). 4 is a representative topographical image of a test sample (dermis) obtained in Experimental Example 2, obtained using an atomic force microscope (AFM). 5 is a representative topographical image of a test sample (dermis) obtained in Experimental Example 3, obtained using an atomic force microscope (AFM). 6 is a representative topographical image of a test sample (dermis) obtained in Experimental Example 4, obtained using an atomic force microscope (AFM).

[0014] The present embodiment is a composition (hereinafter also referred to as "composition" as appropriate) for suppressing a decrease in the thickness of collagen fiber bundles due to UVA irradiation, which contains an ergothioneine compound as an active ingredient.

[0015] According to the present embodiment, a novel function of an ergothioneine compound has been discovered, and a composition utilizing this function can be provided. Specifically, the composition according to the present embodiment was developed based on the discovery that an ergothioneine compound has the effect of suppressing the decrease in thickness of collagen fiber bundles due to UVA irradiation.

[0016] In the present embodiment, collagen fibers refer to a collection of one or more helical structures (hereinafter referred to as tropocollagen) formed by twisting together three polypeptide chains with a collagen-like sequence called α-chains. The number of tropocollagens in a collagen fiber is not particularly limited. Collagen is a protein present in large quantities in connective tissues such as skin, blood vessels, ligaments, tendons, bone, cartilage, and periodontal tissue. It is a major component of the intercellular matrix and serves as a scaffold for adjacent cells, contributing to cell proliferation and signal transduction. Within this connective tissue, collagen mainly forms structures called collagen fiber bundles, in which collagen fibers are tightly bundled by proteoglycans and elastin and regularly arranged, thereby providing the tissue with adequate strength. UVA irradiation of biological tissues containing collagen fiber bundles can reduce the thickness of the collagen fiber bundles and decrease the strength of the tissue. The composition according to the present embodiment can be used to inhibit the reduction in the thickness of collagen fiber bundles due to UVA irradiation, preferably in the dermis of the skin due to UVA irradiation. Furthermore, the composition according to the embodiment can be used to prevent a decrease in the thickness of collagen fiber bundles in biological tissues selected from, for example, skin, ligaments, tendons, cartilage, and periodontal tissues.

[0017] As used herein, the term "ergothioneine compound" refers to ergothioneine or a derivative thereof. An example of the ergothioneine compound is ergothioneine, which is a compound represented by formula (I) and includes all stereoisomers having the structural formula of formula (I). The ergothioneine may be L-ergothioneine.

[0018]

[0019] The ergothioneine derivative is not particularly limited as long as it is a compound having a function equivalent to that of ergothioneine. The ergothioneine derivative is, for example, a compound represented by formula (II), and all stereoisomers having the structural formula of formula (II) are included.

[0020]

[0021] wherein X represents an —O—R′ or —NR′R″ group, and R, R′, and R″ are each independently a hydrogen atom, C １ -C １８ Alkyl group, or C １ -C １８ represents an alkenyl group, which may be linear or branched and may be substituted by one or more substituents.

[0022] For example, R is a hydrogen atom, a methyl group, or an ethyl group, and X is NH ２ is.

[0023] The substituent in formula (II) may be one type or two or more types. The substituent is not particularly limited, but examples thereof include a hydroxyl group, a halogen atom, a carboxyl group, an amine group, and the like.

[0024] An example of an ergothioneine derivative is N,N-dimethyl-L-2-thiohistidine.

[0025] The ergothioneine compound may be in the form of a free form or a salt. The salt may be an inorganic salt or an organic salt. It may be a salt formed with a carboxyl group of the ergothioneine compound, or a salt formed with a trimethylamino group or a dimethylamino group. The ergothioneine compound may also be a solvate such as a hydrate.

[0026] The ergothioneine compound may be used alone or in combination of two or more.

[0027] The content of the ergothioneine compound in the composition according to this embodiment is not particularly limited, but is, for example, in the range of 0.0001% by mass or more and 20% by mass or less, and preferably in the range of 0.01% by mass or more and 10% by mass or less.

[0028] The composition according to the present embodiment is used to suppress the decrease in the thickness of collagen fiber bundles due to UVA irradiation, and is preferably used to suppress the decrease in the thickness of collagen fiber bundles due to UVA irradiation in the dermis of the skin. Furthermore, by applying the composition according to the present embodiment in advance to biological tissue containing collagen fiber bundles, the decrease in the thickness of collagen fiber bundles due to UVA irradiation can be prevented.

[0029] The composition according to the present embodiment is preferably an external skin preparation suitable for topical application to the skin. The external skin preparation is intended, for example, as a cosmetic. The composition according to the present embodiment may contain a cosmetically acceptable excipient or carrier. The cosmetically acceptable excipient or carrier may be used alone or in combination of two or more. The term "cosmetically acceptable excipient or carrier" refers, inter alia, to an excipient or carrier suitable for use in contact with human skin without undue toxicity, incompatibility, instability, or allergic reaction.

[0030] Hereinafter, other ingredients than the ergothioneine compound that may be contained in the topical skin preparation according to this embodiment will be described.

[0031] The topical skin preparation according to this embodiment may contain other ingredients known as cosmetic raw materials (such as plant extracts or compounds that exert various effects) as needed.

[0032] (Plant extract or compound having an effect of improving skin turnover) Examples of plant extracts or compounds having an effect of improving skin turnover include sesame, rehmannia root, peach, licorice, cactus, wheat germ, wild strawberry, sage, mint, peppermint, Houttuynia cordata, cat's claw, perilla, loquat, camellia, taiso, indigo, akebia, angelica tree, asparagus, acerola, altea, aloe, ginkgo, phellodendron bark, hypericum, olive, orange, chamomile, and quince. Grapefruit, cinnamon bark, shell ginger, yuzu, birch, star fruit, Swertia japonica, Morus alba, tea, clove, carrot, hamamelis, rose, Himalayan raspberry, butcher's broom, prune, peach tree, horse chestnut, evening primrose, cornflower, eucalyptus, saxifrage, yuzu, coix seed, orchid, lemon, astragalus, rose hip, rosemary, cherry blossom, fucus, waxberry, gold Extracts of plants such as quince, jasmine, boldo, castor bean, sassafras, angelica, night lily, oak tree, daylily, balsam, forsythia, alfalfa, myrrh, queen's delight, club moss, dayflower, juniper, fig, magnolia, white magnolia, birch, marshmallow, honeysuckle, gardenia, peach kernel, and lily of the valley, seaweed, Examples include chlorella, royal jelly, tangerine, carnitine, nicotinamide, pyridoxine hydrochloride, hyaluronic acid, glycolic acid, citric acid, lactic acid, malic acid, tartaric acid, 2-hydroxybutyric acid, 3-hydroxybutyric acid, tartronic acid, vitamin A, glycyrrhizic acid derivatives, allantoin, diclofenac, felbinac, ibuprofen, ketoprofen, loxoprofen, and salts thereof. These may be blended alone or in combination of two or more.

[0033] The content of the plant extract or compound having the effect of improving skin turnover in the topical skin preparation is usually 0.001% by mass or more, preferably 0.01 to 10% by mass, preferably 0.02 to 5% by mass, and preferably 0.03 to 1% by mass.

[0034] (Plant extract or compound having glycation reaction inhibitory effect) Examples of plant extracts or compounds having glycation reaction inhibitory effect include artichoke, eyebright, blue water, autumn gum, agrimony, agni fruit, akebia, acai fruit, ashwagandha, tulip tree, Acacia catechu, Quercus variabilis, Gynostemma pentaphyllum, anise, American witch hazel, aristin, epimedium, Japanese knotweed, ginkgo, Japanese yew, strawberry, lily of the valley, lily of the valley, loquat, ipe bark, Japanese maple, rock lily, fennel, witch hazel, wintergreen, turmeric, plum, oak, epimedium Brevicornum, star anise, echinacea, Siberian ginseng, broom, hercampuri, elder, erba mate, buttercup palm, Phellodendron bark, Coptis chinensis, milk thistle, oats, cardamom, hijiki, maiden lily, angelica tree, tiger lily, oregano, orange, pumpkin seed, catuaba bark, valerian lily, guarana, karkade, asarum, Kanto, platycodon, Rumex dock, Clerodendron camphorata, winter lily, walnut, cowberry, barberry, sagarame, pomegranate, sweet potato, sarsaparilla, hawthorn, salicaria, perilla, staghorn bean Meadowsweet, Peony, Rhubarb, Scabra, Chenopodium album, White's quarter, Plantain, Red adzuki bean, Buckwheat, Takasago lily, Cardamom, Davila rugosa, Tamotsu lily, Tea bugle, Clove, Senna chinensis, Centella asiatica, Daisy, Dill, Devil's claw, Japanese butterbur, Easter lily, Devil's claw root, Chinese tea, Peach blossom, Houttuynia cordata, Prickly pear, Eucommia tea leaves, Tomato, Tormentilla, Longbush dock, Elderberry, Trumpet, Kung daisy, Mint, Hakata lily, Japanese bush clover, Lotus root, Passion fruit Flower, passion fruit, pfaffia root, jackfruit, celery, sunflower, celery, lily, parasol, areca nut, butterbur, hyacinth bean, black cohosh, safflower daisy, silver vine, matatabi, pine, oak, mate tea, Madonna lily, milk thistle fruit, honeysuckle, Chinese mulberry, mozuku, willow, daylily, soursop, mountain lily, water spinach, yomena, lychee seed, regal lily, Ryukyu bamboo, Ryukyu rose strawberry, unripe apple, linden flower, rooibos, lettuce, lemon,Extracts of plants such as lemongrass, lemon thyme, lemon verbena, lemon balm, rose hips, rose pink buds, rosemary, rose red, laurel, rosea, logwood, burnet, astragalus, persimmon leaves, licorice leaves, black soybean seed coats, black rice seeds, shell ginger leaves, narrow-leaf lily, willow, eucommia leaves, and angelica leaves; extracts of seaweed such as Hanafunori, Fukurofunori, and Mafunori; extracts of green coffee beans, sweet potato shochu lees, and Agaricus mycelium; as well as equol, isoflavones, 1,4-anthraquinone, 1-amino-2-hydroxymethylanthraquinone, 4-aminophenol, 1,3,5-trihydroxybenzene, kojic acid, 3,4-dihydroxyphenylacetic acid, caffeic acid, ifenprodil, 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid, 6-hydroxyindole, 7-hydroxy-4, Examples of compounds that can be added include 6-dimethylphthalide, α-lipoic acid, 4-hydroxychalcone, pearl protein hydrolysate, aminoguanidine, erythrosinate sodium, resveratrol, hydroxystilbenes such as 3,3',5,5'-tetrahydroxystilbene, oxindole, carnosine, salicylic acid, salsolinol hydrobromide, sinapic acid, tocopheryl nicotinate, nicotinamide, nordihydroguaiaretic acid, proanthocyanin, mannitol, hydrolyzed casein, hydrolyzable tannin, catechol, chlorogenic acid, isochlorogenic acid, neochlorogenic acid, cryptochlorogenic acid, chlorogenic acids such as ferulyl caffeoylquinic acid, leucocyanidin, prunin, procyanidol oligomer, and glucosylrutin, and these may be added singly or in appropriate combinations of two or more.

[0035] The content of the plant extract or compound having a glycation reaction inhibitory effect in the topical skin preparation is usually 0.0001% by mass or more, preferably 0.001 to 10% by mass, preferably 0.01 to 5% by mass, and preferably 0.1 to 1% by mass.

[0036] (L-Ascorbic Acid, Its Derivatives, and Salts Thereof) The topical skin preparation according to the present embodiment may contain at least one selected from L-ascorbic acid, its derivatives, and salts thereof. L-ascorbic acid fulfills important physiological functions in the body as vitamin C, and is also used as an antioxidant and anti-inflammatory agent. It also has whitening and collagen production-enhancing properties, making it a widely used compound in the cosmetics field as a useful ingredient. When incorporated into topical skin preparations, L-ascorbic acid can effectively prevent or improve wrinkles, fine lines, age spots, and sagging, and thus can be effectively used in the topical skin preparation according to the present embodiment. The L-ascorbic acid derivative is not particularly limited, as long as it is more stable than L-ascorbic acid, liberates L-ascorbic acid in vivo, and exhibits the inherent functions of L-ascorbic acid. Examples of L-ascorbic acid derivatives include glycosyl derivatives of L-ascorbic acid, acylated derivatives of L-ascorbic acid, and phosphorylated derivatives of L-ascorbic acid. As the glycosyl derivative of L-ascorbic acid, a derivative in which a glycosyl group is bonded to the 2-position of L-ascorbic acid (ascorbic acid 2-glucoside) is preferred because of its high stability.

[0037] The content of L-ascorbic acid, its derivatives or salts thereof in the external skin preparation is usually 0.0001% by mass or more, preferably 0.001 to 50% by mass, preferably 0.001 to 10% by mass, and more preferably 0.01 to 1% by mass.

[0038] [Cosmetics] The topical skin preparation according to this embodiment may be a cosmetic, and the cosmetic may be a basic cosmetic, a makeup cosmetic, a lotion, a facial cleanser, a serum, a milky lotion, a cream, or the like.

[0039] <Lotion> The topical skin preparation according to this embodiment can be prepared as a lotion by further blending at least one selected from the group consisting of ethanol, water, and a moisturizer. Lotions are used to replenish the stratum corneum of the skin with moisture and moisturizing ingredients and to support the physiological functions of the skin. Specific examples of lotions include cleansing lotions, astringent lotions, softening lotions, and multi-layered lotions, as well as skin lotions, body lotions, hand lotions, and emollient lotions.

[0040] (Moisturizing Agent) Examples of moisturizing agents used in the topical skin preparation (e.g., cosmetics, particularly lotion) according to this embodiment include the following: glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, trimethylolpropane, pentaerythritol, diglycerin, polyglycerin, diethylene glycol, triethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, Isoprene glycol, isopentyl diol, hexylene glycol, triglycerin, 2-methacryloyloxyethyl phosphorylcholine, tetrahydrofurfuryl alcohol, polyoxyethylene (POE) tetrahydrofurfuryl alcohol, polyoxypropylene (POP) butyl ether, POP·POE butyl ether, tripolyoxypropylene glycerin ether, POP glycerin ether, POP glycerin ether phosphate, POP·POE pentaerythritol ether, ethylene glycol - Polyhydric alcohols such as propylene glycol copolymer, phytantriol, erythrulose, etc.; glycol alkyl ethers such as ethylene glycol monomethyl ether, ethylene glycol monophenyl ether, ethylene glycol monohexyl ether, diethylene glycol monomethyl ether, triethylene glycol monoethyl ether, monooleyl glycerol ether, diethylene glycol monoethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether, etc.; sugar alcohols such as sorbitol, xylitol, erythritol, mannitol, maltitol, maltotriitol, maltotetriitol, hydrogenated starch hydrolysates, etc.; sucrose, rhamnose, glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, maltotriose, maltotetraose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid,Sulfated trehalose, dextrin, cyclodextrin, cyclic tetrasaccharide (cyclonigerosylnigerose) having the structure cyclo{→6)-α-D-glucopyranosyl-(1→3)-α-D-glucopyranosyl-(1→6)-α-D-glucopyranosyl-(1→3)-α-D-glucopyranosyl-(1→} disclosed in International Publication WO 02 / 10361, cyclonigerosylnigerose described in Japanese Patent Laid-Open No. 2005-95148, and cyclo{→6)-α-D-glucopyranosyl-(1→4)-α-D-glucopyranosyl Cyclic tetrasaccharide having the structure -(1→6)-α-D-glucopyranosyl-(1→4)-α-D-glucopyranosyl-(1→} (cyclomaltosylmaltose), pullulan, isomerized sugar, sugars such as xylitylglucoside, valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, sodium glutamate Amino acids such as hydroxylysine, arginine, ornithine, histidine, and pyrrolidone carboxylic acid, NMF components (natural moisturizing ingredients) such as sodium lactate, uric acid, and sodium pyrrolidone carboxylate, glycogen, dextran, locust bean gum, xyloglucan, quince seed, carrageenan, pectin, mannan, curdlan, succinoglucan, galactan, arabinogalactan, dermatan sulfate, keratan sulfate, chondroitin, chondroitin sulfate, mucoitin sulfate, keratosulfate, chitin, chitosan, heparin, heparan sulfate, and hyaluronic acid. Mucopolysaccharides such as acids and hydrolysates of these mucopolysaccharides, soybean proteolytic peptides, wheat proteolytic peptides, hydrolyzed wheat protein, casein hydrolyzed peptides, acylated peptides such as palmitoyl oligopeptides, silylated peptides, conchiolin hydrolyzed peptides, hydrolyzed conchiolin, proteins and peptides such as silk and collagen and their hydrolysates, water-soluble polymeric substances such as hydrolyzed hyaluronic acid and hydrolyzed eggshell membrane, salts of these, lecithin derived from soybeans, egg yolks, etc., phosphatidylglycerol, phosphatidylinositol, phosphatidylserine,Phosphatidylethanolamine, phosphatidic acid, sphingomyelin and other phospholipids, sphingolipids, olive oil, jojoba oil, squalane and other oils, silicones such as dimethylpolysiloxane and methylphenylsiloxane, culture supernatant of lactic acid bacteria and bifidobacteria, royal jelly extract, yeast extract, eggshell membrane protein, bovine submandibular gland mucin, hypotaurine, galactoarabinan, sesame lignan glycoside, albumin, whey, choline chloride, phosphorylcholine, placenta extract, coix seed extract, peony extract, seaweed extract, gentian extract, saxifrage extract Perilla extract, hydrolyzed rice bran extract, prune enzyme hydrolyzate, trimethylglycine, N-methyl-L-serine, nicotinamide, Scutellaria root extract, tea extract, Centella asiatica extract, mulberry extract, hydrolyzed white oak extract, sodium acetyl hyaluronate, Althaea officinalis extract, Angelica acutiloba extract, aloe extract, sodium deoxyribonucleic acid, melothria extract, carrot extract, Houttuynia cordata extract, oolong tea extract, wheat germ extract, xylobiose mixture, Mokuzu extract, Phellodendron bark extract, Hypericum perforatum extract, Pueraria root extract, whey, cherry blossom leaf Extract, peony extract, burnet extract, acerola extract, bean jasmine extract, edelweiss extract, almond extract, glucosyl hesperidin, yellow himalayan raspberry root extract, peppermint extract, rehmannia root extract, mevalonolactone, angelica tree extract, ginkgo extract, horsetail extract, hydrolyzed black bean extract, thyme extract, coptis japonica extract, adenosine monophosphate, adenosine triphosphate disodium, dl-α-tocopherol, sodium DL-malate, γ-amino-β-hydroxybutyric acid, tsubaki extract, asparagus extract, Aspalathus linearis extract, avocado extract, apricot juice, mussel glycogen, inositol, Ibuki toranou extract, nettle extract, turmeric extract, Uva-ursi extract, Ageratum extract, Echinacea leaf extract, ethyl glucoside, Lagerstroemia indicum extract, Panax ginseng extract, Ononis extract, olive leaf extract, persimmon extract, cattail extract, camu camu extract, camu camu seed extract, carrot extract, raspberry extract, kiwi extract, guava extract, gardenia extract, Sasa veitchii extract, Sophora flavescens extract, glycolic acid, grapefruit extract,Clematis extract, chlorella extract, Cape aloe extract, Geranium herb extract, coffee extract, 2-(2-hydroxyethoxy)ethylguanidine succinate, rice bran extract hydrolyzate, collagen tripeptide, Chinese radish extract, succinyl atelocollagen, hawthorn extract, sunflower extract, cyanocobalamin, seagrass extract, linden extract, dimethylsilanol-hyaluronic acid condensation solution, meadowsweet extract, calamus root extract, white birch extract, silk extract, silk powder, honeysuckle extract, starfruit leaf extract, strawberry juice, ivy extract, hawthorn extract, Swertia japonica extract, Morus alba extract, sorbitol fermented polysaccharide solution, soybean extract, tallow extract, camellia extract, daisy extract, terminalia extract, tangerine extract, peach kernel extract, spruce extract, corn extract, tomato juice, wild rose extract , hibiscus extract, lupin extract, burdock root extract, wormwood extract, lotus seed lactic acid bacteria fermentation liquid, parsley extract, rosehip extract, hamamelis extract, rose extract, parietaria extract, pancratium maritimum extract, bean jasmine extract, loquat leaf extract, phytoglycogen, butcher's broom extract, balsam extract, sodium polyaspartate liquid, marjoram extract, lily extract, indigo water extract, horse chestnut extract, elastoma Examples of suitable ceramides include ceramides such as cinnamal, natural ceramides (types 1, 2, 3, 4, 5, 6, 9), caprooylphytosphingosine, caprooylsphingosine, hydroxyceramide, pseudoceramide, glycosphingolipids, ceramide and glycoceramide-containing extracts, deep sea water, alkaline simple hot spring water, polyoxyethylene methyl glucoside, sodium dl-pyrrolidone carboxylate, L-oxyproline, acetylglucosamine, taurine, etc. That is, glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, 3-methyl-1,3-butanediol, pentaerythritol, diglycerin, polyglycerin, diethylene glycol, triethylene glycol, polyethylene glycol, dipropylene glycol, trehalose, glycosyl trehalose, hydrolyzed hydrogenated starch, lysophosphatidic acid, lysolecithin, lecithin, ectoine,It is desirable to use at least one moisturizer selected from etidronic acid, squalane, ceramides, 2-methacryloyloxyethyl phosphorylcholine, hyaluronic acid, chondroitin sulfate, hydrolyzed hyaluronic acid, yeast extract, coix seed extract, peony extract, seaweed extract, gentian extract, trimethylglycine, N-methyl-L-serine, nicotinamide, and royal jelly extract. One moisturizer may be used alone, or two or more may be used in combination.

[0041] The content of the moisturizing agent in the external skin preparation is usually 0.0001% by mass or more, preferably 0.001 to 50% by mass, preferably 0.01 to 25% by mass, and more preferably 0.1 to 10% by mass.

[0042] Furthermore, the topical skin preparation according to this embodiment (e.g., a cosmetic product, particularly a lotion) may contain at least one selected from the following astringents, keratin softeners, emollients, and surfactants, depending on its purpose and function.

[0043] (Astringents) Astringents include citric acid, tannic acid, acetoxypropionic acid, isovaleric acid, aminovaleric acid, ethoxyacetic acid, ethoxypropionic acid, isoaminovaleric acid, epoxyoleic acid, elaidic acid, aminobutyric acid, erucic acid, oxaloacetic acid, formic acid, icosanoic acid, glucuronic acid, iduronic acid, crotonic acid, chloroisocrotonic acid, isocrotonic acid, acetic acid, dihydrolipoic acid, tartaric acid, ethylcrotonic acid, diphenylacetic acid, dimethoxyphthalic acid, ethylhydroxybutyric acid, succinamic acid, stearic acid, stearic acid, sorbic acid, tiglic acid, thyroxine, Decanoic acid, tropic acid, lactic acid, hydroxyisobutyric acid, hydroxyvaleric acid, pyruvic acid, butylacetic acid, butyl hydroperoxide, brassidic acid, propiolic acid, propionic acid, bromoisovaleric acid, bromoisobutyric acid, bromopropionic acid, hexanoic acid, hexenoic acid, petroselinic acid, heptadecanoic acid, heptanoic acid, areanilic acid, maleamic acid, mycolic acid, myristic acid, methacrylic acid, methylvaleric acid, methylthioacetic acid, methylbutyric acid, mevalonic acid, melissic acid, mercaptoacetic acid, iodoacetic acid, lauric acid, ricineraidic acid, ricinoleic acid, linoleic acid, Linolenic acid, aconitic acid, oxalosuccinic acid, oxoglutaric acid, adipic acid, calcein, carboxyphenylacetic acid, acetoxysuccinic acid, carboxycomellonic acid, camphoronic acid, isocamphoronic acid, glutaconic acid, glutaric acid, isocitric acid, crocetin, succinic acid, phthalic acid, fumaric acid, isocinchomeronic acid, diethylenetriaminepentaacetic acid, isophthalic acid, citramalic acid, dinicotinic acid, itaconic acid, dibromosuccinic acid, dichlorosuccinic acid, ethylmalonic acid, dimethylsuccinic acid, oxalic acid, cinchomeronic acid, hemimellitic acid, pelargonic acid, bell Veronic acid, benzenehexacarboxylic acid, benzenepentacarboxylic acid, maleic acid, malonic acid, mesaconic acid, mesotartaric acid, mesoxalic acid, methylisophthalic acid, methylsuccinic acid, methylmalonic acid, mercaptosuccinic acid, mellophanic acid, peroxyphthalic acid, malic acid, lutidic acid, leukotriene bromoanthranilic acid, aminocinnamic acid, isopropylcinnamic acid, oxanilic acid, arecaidine, carboxycinnamic acid, cinnamic acid, galloyl gallic acid, tranexamic acid, nitrocinnamic acid, hydroxycinnamic acid, methoxycinnamic acid, hydroxyhydrocinnamic acid,Phenylcinnamic acid, ellagic acid, orotic acid, camphanic acid, quinic acid, hydroxyproline, etiocholanic acid, caulmoglic acid, carnosine, carbazole acetic acid, quinoline carboxylic acid, quinolinic acid, quinoline dicarboxylic acid, coumaric acid, chlorophenoxyacetic acid, chenodeoxycholic acid, cholanic acid, cholic acid, santonic acid, dihydroorthoic acid, succininal acid, thiophene carboxylic acid, tetrahydrofolic acid, dehydrocholic acid, terpenic acid, hydroxypyrone carboxylic acid, hydroxypyrone dicarboxylic acid, hydroxyphenylacetic acid, hydroxyphenylproline Pionic acid, biphenyldicarboxylic acid, homogentisic acid, mandelic acid, muricholic acid, methyldopa, methylphenylacetic acid, methylfurancarboxylic acid, methyl red, mefenamic acid, lysergic acid, lithocholic acid, lipoic acid, reserpic acid, retinoic acid, levopimaric acid, glycolic acid, salicylic acid, zinc paraphenolsulfonate, Althaea officinalis, Arnica officinalis, Iris, Fennel, Crape myrtle, Orange, Rubus idaeus, Guava, Black currant, Geranium herb, Hawthorn, Meadowsweet, Peony, Birch, Honeysuckle, Horsetail, Ivy, thyme, tea, parsley, hamamelis, grapes, cornflower, lemon, astragalus, burnet, cinchona, salvia, linden tree, ginseng, juniper, rosemary, St. John's wort, ginkgo, melissa, ononis, horse chestnut, Swertia japonica, garlic, chamomile, thyme, peppermint, nettle, chili pepper, ginger, hops, horse chestnut, lavender, carrot, mustard, zelkova, pine, cnidium, elderberry, mountain watercress, water hyacinth, peony, Japanese bayberry, Houttuynia cordata, water hyacinth, water chestnut, calendula, lily of the valley, and phosphorus Extracts of plants such as dou, hamamoku, bitter orange, yuzu, calamus, summer mandarin, mary loaf, Japanese pepper, eucalyptus, mugwort, emmeiso, rice, sophora flavescens, ginger, clove, walnut leaves, Scutellaria root, sage, rosemary, Polygonum multiflorum, Coptis Rhizome, Phellodendron bark, Scutellaria lobata, tangerine peel, ginseng, Doshin, Takusia, tannins, birch tar, etc., propolis, royal jelly, yeast extract, tuberose polysaccharide solution, oolong tea, alum, zinc chloride, zinc sulfate, aluminum sulfate, aluminum chloride, allantoin chlorohydroxyaluminum,Examples of the astringent include allantoin dihydroxyaluminum, chlorohydroxyaluminum, zinc oxide, zinc sulfide, zinc sulfophenone, sodium sulfophenone, and organic composite salts of aluminum and zirconium. One type of astringent may be used alone, or two or more types may be used in combination.

[0044] The content of the astringent in the external skin preparation is usually 0.0001% by mass or more, preferably 0.001 to 50% by mass, preferably 0.01 to 25% by mass, and preferably 0.1 to 10% by mass.

[0045] In particular, the topical skin preparation (e.g., cosmetics, particularly lotion) according to this embodiment may contain, for example, an acid agent having an excellent astringent effect, such as citric acid, succinic acid, tartaric acid, retinoic acid, or malic acid; retinol; zinc chloride; aluminum powder; aluminum compounds such as aluminum sulfate; alum; and denatured alcohol; ethanol; Althaea extract; Arnica extract; Ibukitora extract; Nettle extract; Iris root extract; Fennel extract; Oolong tea extract; ethanol; Lagerstroemia indicum extract; Hypericum perforatum extract; orange flower water; orange juice; and Artemisia capillaris extract. It is desirable to use at least one astringent selected from the group consisting of raspberry extract, guava extract, black currant fruit extract, geraniol, geranium herb extract, hawthorn extract, meadowsweet extract, peony extract, white birch extract, honeysuckle extract, horsetail extract, ivy extract, hawthorn extract, thyme extract, tea extract, Houttuynia cordata extract, parsley extract, witch hazel extract, grape leaf extract, pine extract, melissa extract, cornflower extract, mugwort extract, lemon juice, astragalus extract, and burnet extract.

[0046] (Keratin softeners) Examples of keratin softeners include ethanol, isopropyl alcohol, propanol, butanol, polyethylene glycol, benzyl alcohol, phenylethyl alcohol, propylene carbonate, hexyldodecanol, dimethyl sulfoxide, dimethylacetamide, dimethylformamide, triethanolamine, diisopropyl adipate, ethyl laurate, lanolin, fatty acid dialkylolamide, urea, sulfur, resorcinol, phytic acid, lactic acid, lactate salts, glycolic acid, sodium hydroxide, potassium hydroxide, etc. One type of keratin softener may be used alone, or two or more types may be used in combination.

[0047] (Emollient) As an emollient (softener), an oily component similar to sebum is desirable. Examples of oily components include hemp seed oil, Astrocaryum murumuru butter, rapeseed oil, African mango kernel oil, Camellia sinensis seed oil, Argania spinosa kernel oil, apricot kernel oil, sea buckthorn oil, Ethium plantagineum seed oil, emu oil, orange roughy oil, canola oil, kaya seed oil, Garcinia indica seed oil, caraway seed oil, apricot kernel oil, kukui nut oil, crambe avianica seed oil, cranberry seed oil, walnut seed oil, black currant seed oil, Seed oil, cowberry seed oil, rice germ oil, Japanese cedar seed oil, camellia oil, sal seed oil, oxidized corn oil, shea butter, Shorea sthenoptera oil, white lupin seed oil, hydrogenated avocado oil, hydrogenated olive oil, hydrogenated beef tallow, hydrogenated soybean oil, hydrogenated rapeseed seed oil, hydrogenated milk fat, hydrogenated palm kernel oil, hydrogenated palm oil, hydrogenated castor oil, hydrogenated jojoba oil, hydrogenated vegetable oil, hydrogenated coconut oil, Sclerocarya birrea oil, ostrich oil, passionflower seed oil, tea seed oil, camellia oil, cranberry seed oil, Theobroma grandiflorum seed fat, lard, milk fat, Job's tears oil, babassu oil, pea Nut oil, pistachio seed oil, Hippophae rhamnoides oil, sunflower seed oil, bilberry seed oil, grape seed oil, partially hydrogenated perilla oil, partially hydrogenated horse oil, prune seed oil, broccoli seed oil, loofah seed oil, Cucurbita pepo seed oil, tomato coccus pluvialis oil, rubus chamaemorus seed oil, pine seed oil, mango seed oil, mink oil, Melia azadirachta seed oil, peach kernel oil, vegetable oil, camellia sinensis oil, rubus idaeus seed oil, apple seed oil, borage seed oil, rosehip oil, moringa seed oil, macadamia nut oil, castor oil, olive oil , almond oil, cacao oil, camellia oil, coconut oil, palm oil, wood wax, jojoba oil, grapeseed oil, avocado oil, safflower oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, hazelnut oil, meadowfoam oil, persic oil, peppermint oil, tea tree oil, corn oil, rapeseed oil, sunflower oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, cacao butter, shea butter, fennel oil, perilla oil, chamomile oil, carrot oil, cucumber oil, egg yolk oil, beef tallow, horse fat, fish oil, turtle oil, orange roughy oil and other vegetable or animal oils and fats, urushi peel wax,Waxes such as Jasmine flower wax, orange peel wax, orange flower wax, hydrolyzed jojoba esters, carnauba wax, candelilla wax, daffodil flower wax, rice bran wax, white bayberry fruit wax, sweet acacia flower wax, tuberose flower wax, beeswax, spermaceti, orange roughy oil, lanolin, rice wax, montan wax, ozokerite, isoeicosane, isododecane, isohexadecane, diethylhexylcyclohexane, pentahydrosqualene, mineral oil, liquid paraffin, polyisobutene, hydrogenated polyisobutene Hydrocarbons such as cellulose, polybutene, squalane, squalene, microcrystalline wax, ceresin wax, paraffin wax, petrolatum, ozokerite, α-olefin oligomers, and tetradecene, isomerized linoleic acid, beef tallow fatty acid, fatty acid (C14-28), fatty acid (C20-40), hydrogenated coconut fatty acid, palm kernel fatty acid, 10-hydroxydecanoic acid, branched fatty acid (C14-28), branched fatty acid (C12-31), behenic acid, capric acid, myristic acid, palmitic acid, stearic acid, behenic acid, lanolin fatty acid, linoleic acid, linolenic acid, lauric ... Natural and synthetic fatty acids such as phosphoric acid, oleic acid, isostearic acid, undecylenic acid, 1,2-hydroxystearic acid, palmitoleic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexadecanoic acid, anteisohenicosanoic acid, isononanoic acid, 2-ethylhexanoic acid, and their salts, (C12-16) alcohol, (C14-22) alcohol, (C20-22) alcohol, (C20-40) alcohol, (C30-50) alcohol, rapeseed sterol, isocetyl alcohol, isopropanol, caprylyl Glycol, rice bran sterol, hydrogenated rapeseed oil alcohol, cetyl alcohol, stearyl alcohol, hexyldecanol, octyldodecanol, lauryl alcohol, caprylic alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol, arachyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, selachyl alcohol, batyl alcohol, isostearyl alcohol, cetyl alcohol, cholesterol, phytosterol, lanolin alcohol, hydrogenated lanolin alcohol, palmityl alcohol,Natural and synthetic higher alcohols such as 2-decyltetradecynol, (C12-15) isopropyl pareth-9 carboxylate, octyldodecyl pyrrolidone carboxylate, menthyl pyrrolidone carboxylate, lauryl pyrrolidone carboxylate, PEG-2 isodeceth-7 cetyl carboxylate, di-PPG-3 myristyl adipate, di-PPG-2 myreth-10 adipate, diisopropyl adipate, diheptylundecyl adipate, avocado fatty acid ethyl ester, avocado oil fatty acid butyl ester, methyl gluceth-20 benzoate, ethyl isostearate, (isostearin Ingredients: Castor Oil (Isostearate / Beeswax / Succinic Acid), Hydrogenated Castor Oil Isostearate, Batyl Isostearate, Hexyldecyl Isostearate, Castor Oil (Isostearate / Beeswax / Succinic Acid), Isodecyl Isononanoate, Isotridecyl Isononanoate, Isononyl Isononanoate, Octyl Isononanoate, Cetearyl Isononanoate, Sucrose Acetate Isobutyrate, Caprylyl Eicosenoate, Butyl Ethyl Propanediol Ethylhexanoate, Octyldodecyl Erucate, Oleyl Erucate, Alkyl C14, 16, 18 Octanoate, (Octanoate / Stearic Acid / Adipic Acid) Glyceryl octanoate, cetyl octanoate, cetearyl octanoate, hexyldecyl octanoate, ethyl olivate, oleyl oleate, caprylic / capric glycerides, caprylic / capric / coconut acid glyceryl, caprylic / capric / succinic acid triglyceride, cetyl caprate, triisostearyl citrate, triisooctyldodecyl citrate, glyceryl citric / lactic / linoleic / oleic acid, isostearyl diglyceryl succinate, diethoxyethyl succinate, dioctyl succinate, rice bran oil fatty acid fluoride Fritillyl acetate, cetyl acetate, farnesyl acetate, lanolin alcohol acetate, linalyl acetate, propylene glycol diisostearate, dimer dilinoleyl diisostearate, neopentyl glycol diisostearate, neopentyl glycol diethylhexanoate, PEG-18 castor oil dioleate, butylene glycol dicaprylate-caprate, isosorbide dicaprate, polyethylene glycol dicaprylate-caprate, dicocoyl pentaerythrityl distearyl citrate, polyethylene glycol distearate,PG-20 methyl glucose distearate, pentaerythrityl distearate, diethyl pentanediol dineopentanoate, methyl pentanediol dineopentanoate, polyethylene glycol dinonanoate, C10-30 fatty acid (cholesteryl / lanosteryl), C12-18 fatty acid cetyl, glycol dilaurate, diisopropyl dilinoleate, pentaerythrityl hydrogenated rosinate, methyl hydrogenated rosinate, glyceryl (hydrogenated rosin / diisostearate), ethylhexyl stearate, isocetyl stearoyloxystearate, Octyldodecyl stearoyloxystearate, dibutyloctyl sebacate, octyldodecyl dimer dilinoleate / PPG-3 myristyl ether, di(isostearyl / phytophytosteryl) dimer dilinoleate, dicetearyl dimer dilinoleate, hydrogenated castor oil dimer dilinoleate, stearyl dimer dilinoleate / PPG-3 myristyl ether, dimer dilinoleyl dimer dilinoleate, dimer dilinoleyl bis(behenyl / isostearyl / phytophytosteryl) dimer dilinoleate, dimer dilinoleyl (fructose) dimer dilinoleate Phytosteryl / Isostearyl / Cetyl / Stearyl / Behenyl), Dimer Dilinoleyl Hydrogenated Rosin Condensate, Dialkyl Carbonate (C14,15), Diethylhexyl Carbonate, Dicaprylyl Carbonate, Pentaerythrityl Tetraisostearate, Pentaerythrityl Tetraoctanoate, Dodeca (Caprylic / Capric) Polyglyceryl-10, Diisocetyl Dodecanedioate, Dioctyldodecyl Dodecanedioate, Triisostearin, Erythrityl Triethylhexanoate, Ditrimethylolpropane Triethylhexanoate, Trioctanoin, Trioctanoin Trimethylolpropane Phosphate, Tricaprylin, Caprylic / Capric Triglyceride, Caprylic / Capric / Stearic Triglyceride, Caprylic / Capric / Myristic / Stearic Triglyceride, C8-12 Triglycerides, Tristearin, Tripalmitin, Tripalmitolein, Trihydroxystearin, Tribehenin, Dipentaerythrityl Tri-Polyhydroxystearate, Trimyristin, C12-15 Alkyl Lactate, Ethyl Lactate, Octyldodecyl Lactate, Butyl Lactate, Menthyl Lactate,Isodecyl neopentanoate, myristyl neopentanoate, octyl nonanoate, cholesteryl nonanoate, ethylhexyl palmitate, cetyl palmitate, bis-diglyceryl polyacyladipate-1, bis-diglyceryl polyacyladipate-2, dipentaerythrityl hydroxystearate / isostearate, ethylhexyl hydroxystearate, octyl hydroxystearate, hydrogenated castor oil hydroxystearate, dipentaerythrityl hydroxystearate / stearic acid / rosinate, hydroxystearic acid Phytosteryl, Castor Fatty Acid PPG-5.5, Castor Fatty Acid Methyl, Myristyl Propionate, C12-31 Branched Cholesteryl Fatty Acid, Dipentaerythrityl Hexahydroxystearate, Dipentaerythrityl Hexa(Hexahydroxystearate / Hexastearic acid / Hexarosinate), Stearyl Heptanoate, Glyceryl Behenate / Eicosanedioate, Jojoba Esters, Jojoba Fatty Acid Isopropyl, Ethyl Macadamiate, Cholesteryl Macadamiate, Phytosteryl Macadamiate, Dioctyl Maleate, Malonic Acid Diethylhexyl syringylidene, hexyldecyl myristoyl methylaminopropionate, citronellyl methylcrotonate, meadowfoam estolide, octyldodecyl meadowfoam oil fatty acid, glyceryl cocoate / citric acid / lactic acid, decyl cocoate, cholesteryl butyrate, dihydrocholesteryl butyrate, octyldodecyl lanolinate, cholesteryl lanolinate, octyldodecyl ricinoleate, diethylhexyl malate, trioleyl phosphate, tricetyl phosphate, glyceryl tri-2-ethylhexanoate (triethylhexyl) xanoin), cetyl 2-ethylhexanoate, neopentyl glycol di-2-ethylhexanoate, isopropyl myristate, butyl myristate, isopropyl palmitate, ethyl stearate, octyl palmitate, isocetyl isostearate, butyl stearate, ethyl linoleate, isopropyl linoleate, ethyl oleate, isocetyl myristate, isostearyl myristate, isostearyl palmitate, octyldodecyl myristate, diethyl sebacate, diisopropyl dipicate, isoarachidyl neopentanoate,Caprylic / Capric Triglyceride, Trimethylolpropane Tri-2-Ethylhexanoate, Trimethylolpropane Triisostearate, Pentaerythritol Tetra-2-Ethylhexanoate, Cetyl Caprylate, Decyl Laurate, Hexyl Laurate, Decyl Myristate, Myristyl Myristate, Cetyl Myristate, Glycerin Trimyristate, Stearyl Stearate, Decyl Oleate, Cetyl Ricinoleate, Isostearyl Laurate, Isotridecyl Myristate, Isocetyl Palmitate, Octyl Stearate, Isocetyl Stearate, Isodecyl Oleate, Octyldodecyl Oleate, Octyldodecyl Linoleate, Isopropyl Isostearate, Cetostearyl 2-Ethylhexanoate, Stearyl 2-Ethylhexanoate, Hexyl Isostearate, Ethylene Glycol Dioctanoate, Di Ethylene glycol oleate, propylene glycol dioleate, propylene glycol dicaprate, propylene glycol dicaprylate, propylene glycol dicaprate, glycerin tricaprylate, propylene glycol dicaprate, neopentyl glycol dioctanoate, glyceryl tricaprylate, glyceryl triundecylate, glyceryl triisopalmitate, glyceryl triisostearate, neopentyl glycol diisostearate, glyceryl tri ... Octyldodecyl octanoate, isostearyl octanoate, hexyldecyl neodecanoate, octyldodecyl neodecanoate, isostearyl isostearate, octyldecyl isostearate, polyglycerin oleate, polyglycerin isostearate, dipropyl carbonate, dialkyl carbonate (C12-18), triisocetyl citrate, triisoarachidyl citrate, triisooctyl citrate, lauryl lactate, myristyl lactate, cetyl lactate, milk Octyldecyl citrate, lanolin lactate, triethyl citrate, acetyltriethyl citrate, acetyltributyl citrate, trioctyl citrate, diisostearyl malate, 2-ethylhexyl hydroxystearate, di-2-ethylhexyl succinate, diisobutyl adipate, diisopropyl sebacate, dioctyl sebacate, cholesteryl stearate, cholesteryl isostearate, cholesteryl hydroxystearate, cholesteryl oleate,Dihydrocholesteryl oleate, phytosteryl isostearate, phytosteryl oleate, isocetyl 12-stearoylhydroxystearate, stearyl 12-stearoylhydroxystearate, isostearyl 12-stearoylhydroxystearate, hexyldecyl dimethyloctanoate, lanolin fatty acid isopropyl esters, etc., liquid lanolin, reduced lanolin, adsorption-purified lanolin, acetated lanolin, acetated liquid lanolin, hydroxylanolin, polyoxyethylene lanolin, hard lanolin fatty acid, lanolins such as cetyl lanolyl acetate esters, sphingophospholipids such as sphingomyelin, hydrogenated soybean phospholipids, partial Examples of emollients include phospholipid derivatives such as hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, and partially hydrogenated egg yolk phospholipid; sterols such as dihydrocholesterol, lanosterol, dihydrolanosterol, and cholic acid; silicone oils such as methylphenylpolysiloxane, methylhydrogenpolysiloxane, octamethylcyclotetrasiloxane, stearoxysilicone, decamethylcyclopentasiloxane, tetramethyltetrahydrogencyclotetrasiloxane, and dodecamethylcyclohexasiloxane; sapogenins, saponins, and fluorine-based oils such as perfluoropolyether, perfluorodecalin, and perfluorooctane. One type of emollient may be used alone, or two or more types may be used in combination.

[0048] In particular, for the topical skin preparation according to this embodiment (e.g., cosmetics, particularly lotions), it is desirable to use at least one emollient selected from the group consisting of cetanol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, oleyl alcohol, behenyl alcohol, lanolin alcohol, hydrogenated lanolin alcohol, hexyldecanol and octyldodecanol, squalane, vegetable squalane, cetyl 2-ethylhexanoate, α-olefin oligomer, isotridecyl isononanoate, isononyl isononanoate, cetearyl isononanoate, ethyl oleate, oleyl oleate, ethylhexyl palmitate, caprylyl glycol, and hydrogenated soybean phospholipid, which have excellent emollient effects and are widely used in the field of cosmetics.

[0049] (Surfactant) Examples of the surfactant include sorbitan monolaurate, coconut oil fatty acid sorbitan, sorbitan distearate, sorbitan monostearate, sorbitan tristearate, sorbitan monoisostearate, sorbitan monooleate, sorbitan trioleate, sorbitan fatty acid ester, sorbitan monopalmitate, sorbitan sesquioleate, sorbitan sesquistearate, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monostearate, ethylene glycol monostearate, and ethylene distearate. Glycol, Diethylene Glycol Distearate, Ethylene Glycol Fatty Acid Esters, Glyceride Monostearate, Glyceryl Distearate, Glyceryl Isostearate, Polyoxyethylene Glyceryl Isostearate, Polyoxyethylene Glyceryl Triisostearate, Diglyceryl Isostearate, Glyceryl Diisostearate, Glyceryl Triisostearate, Diglyceryl Triisostearate, Propylene Glycol Monostearate, Self-Emulsifying Propylene Glycol Stearate, Glyceryl Ricinoleate , Propylene glycol ricinoleate, Propylene glycol fatty acid esters, Propylene glycol dioleate, Propylene glycol laurate, Glyceryl linoleate, Glyceryl diisopalmitate, Glyceryl sesquioleate, Glyceryl monooleate, Glycerin trimyristate, Isopropyl lanolinate, Hexyldecyl dimethyloctanoate, Acetoglyceryl, Glyceryl triisooctanoate, Glyceryl di-2-heptylundecanoate, Glyceryl oleate pyroglutamate, Decaglyceryl decaoleate, Diglyceryl Pentaerythritol fatty acid ester, glyceryl stearate malate, polyoxyethylene hydrogenated castor oil laurate, polyoxyethylene alkyl (12-14) ether (7 E.O.), polyoxyethylene alkyl (12-14) ether (12 E.O.), polyoxyethylene alkyl ether (20 E.O.), polyoxyethylene lauryl ether, polyoxyethylene myristyl ether, polyoxyethylene cetyl ether, polyoxyethylene cetostearyl ether (ceteareth-25), polyoxyethyl stearyl ether,Polyoxyethylene oleyl ether, polyoxyethylene oleyl cetyl ether, polyoxyethylene behenyl ether, polyoxyethylene octylphenyl ether, polyoxyethylene nonylphenyl ether, polyoxyethylene alkyl (12,13) ​​ether (10 E.O.), polyoxyethylene octyldodecyl ether, polyoxyethylene cetylstearyl diether, polyoxyethylene methyl glucoside sesquistearate, carboxylated polyoxyethylene tredecyl ether, polyethylene glycol (4) octanoate polyoxyethylene nonylphenyl ether (14 E.O.) mixture, polyoxyethylene lanolin alcohol, polyoxyethylene (5) lanolin alcohol, polyoxyethylene (10) lanolin alcohol, polyoxyethylene (15) lanolin alcohol, polyoxyethylene (20) lanolin alcohol, polyoxyethylene (25) lanolin alcohol, polyoxyethylene (40) lanolin alcohol, polyoxyethylene (alkylol lanolin alcohol) ether (16 E.O.), polyoxyethylene acetate Lanolin alcohol, polyoxyethylene lanolin, polyoxyethylene reduced lanolin, polyoxyethylene sorbitol lanolin (40 E.O.), polyoxyethylene polyoxypropylene reduced lanolin, polyoxyethylene polyoxypropylene lanolin, polyoxyethylene polyoxypropylene liquid lanolin, polyoxyethylene stearic acid amide, polyoxyethylene phytosterol, polyoxyethylene dinonylphenyl ether, polyethylene glycol monolaurate, polyethylene glycol dilaurate, polyethylene glycol palmate, polyethylene glycol dipalmitate, polyethylene glycol dipalmitate, polyethylene glycol monooleate, polyethylene glycol 150 dioleate, polyethylene glycol monostearate, polyethylene glycol distearate, polyoxyethylene glyceryl tristearate, polyethylene glycol 300 lanolinate, polyethylene glycol 600 lanolinate, polyethylene glycol 1000 lanolinate, polypropylene glycol monooleate (36),Polyoxyethylene sorbitan monolaurate (20 E.O.), polyoxyethylene coconut oil fatty acid sorbitan (20 E.O.), polyoxyethylene sorbitan monopalmitate (20 O.E.), polyoxyethylene sorbitan oleate (40 E.O.), polyoxyethylene sorbitan monooleate (6 E.O.), polyoxyethylene sorbitan monooleate (20 E.O.), polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan tetraoleate, polyoxyethylene sorbitan trioleate (20 E.O.), Polyoxyethylene sorbitan monostearate (6 E.O.), Polyoxyethylene sorbitan monostearate (20 E.O.), Polyoxyethylene sorbitan tristearate (6 E.O.), Polyoxyethylene sorbitan hexastearate, Polyoxyethylene sorbitan isostearate (3 E.O.), Polyoxyethylene glyceryl monostearate, Polyoxyethylene sorbit beeswax, Polyoxyethylene polyoxypropylene butyl ether, Polyoxyethylene (20) Polyoxypropylene (15) Butyl ether, polyoxyethylene (35) polyoxypropylene (28) butyl ether, polyoxyethylene (36) polyoxypropylene (36) butyl ether, polyoxyethylene (37) polyoxypropylene (38) butyl ether, polyoxyethylene polyoxypropylene cetyl ether, polyoxyethylene polyoxypropylene decyl tetradecyl ether, polyoxyethylene polyoxypropylene oligosuccinate (3E.O.) (20P.O.), polyoxyethylene polyoxypropylene hexylene glycol ether ether (300 E.O.) (75 P.O.), tri(polyoxyethylene isostearate) trimethylolpropane (3 E.O.), polyoxyethylene glyceryl oleate, polyoxyethylene (10) polyoxypropylene glycol (30), polyoxyethylene (16) polyoxypropylene glycol (30), polyoxyethylene (25) polyoxypropylene glycol (30), polyoxyethylene (160) polyoxypropylene glycol (30), polyoxyethylene (30) polyoxypropylene glycol (35),Polyoxyethylene (200) polyoxypropylene glycol (40), polyoxyethylene (200) polyoxypropylene glycol (70), polyoxyethylene (20) polyoxypropylene glycol (15) butyl ether, polyoxyethylene (6) polyoxypropylene glycol (30), polyoxyethylene (1) polyoxypropylene (4) cetyl ether, polyoxyethylene (1) polyoxypropylene (8) cetyl ether, polyoxyethylene (20) polyoxypropylene (4) cetyl ether, polyoxyethylene Polyoxypropylene (20) Cetyl Ether, Polyoxypropylene (9) Diglyceryl Ether, Polyoxypropylene Stearyl Ether, Ethylenediaminetetrapolyoxyethylene Polyoxypropylene, Polyoxyethylene (6E.O.) Caprylic / Capric Triglyceride, Polyoxyethylene Glyceryl Laurate, Polyoxyethylene Glyceryl Cocoate, Polyoxyethylene Diethanolamine Laurate (4E.O.), Dioctyldodecyl Lauroyl Glutamate, Dipolyoxyethylene Lauroyl Glutamate Diethylene stearyl ether diester, polyoxyethylene octyldodecyl ether diester of lauroyl glutamic acid, polyoxyethylene glyceryl pyroglutamate isostearate, polyoxyethylene hydrogenated castor oil pyroglutamate isostearate, capric diethanolamide, undecylenic monoethanolamide, coconut oil fatty acid monoethanolamide, coconut oil fatty acid diethanolamide (1:2 type), coconut oil fatty acid diethanolamide, lauric ethanolamide, lauric diethanolamide, lauric isopropanolamide, lauric myristic diethanolamide, lauric myristic triethanolamine diethanolamide, myristic diethanolamide, palmitic ethanolamide, stearic acid monoethanolamide, stearic acid diethanolamide, stearic acid diethylaminoethylamide, isostearic diethanolamide, oleic diethanolamide, linoleic diethanolamide, beef tallow fatty acid monoethanolamide, beef tallow fatty acid diethanolamide, hydrogenated beef tallow fatty acid diethanolamide, lanolin fatty acid diethanolamidePolyoxyethylene coconut oil fatty acid amide (5E.O.), polyoxyethylene (2) coconut oil fatty acid monoethanolamide, polyoxyethylene (5) coconut oil fatty acid monoethanolamide, polyoxyethylene (10) coconut oil fatty acid monoethanolamide, polyoxyethylene coconut oil fatty acid diethanolamide, polyoxyethylene beef tallow alkyldiethanolamine (2E.O.), polyoxyethylene coconut oil alkyldimethylamine oxide, coconut oil alkyldimethylamine oxide liquid, stearyl dimethylamine oxide, oleyl dimethylamine oxide, dihydroxyethyl laurylamine oxide liquid, pentaerythritol rosinate, hexaglyceryl oleate, methyl glucoside sesquistearate, polyethylene glycol monooleate, polyethylene glycol alkylate, polyoxyethylene alkyl ether, polyglycol diether, lauroyl diethanolamide, fatty acid isopropanolamide, maltitol hydroxy fatty acid ether, alkylated polysaccharide, alkyl glucoside, trehalose monomyristate, trehalose monoisostearate, monoundecyl Trehalose mono fatty acid esters such as trehalose dioleate, polyoxyethylene methyl glucoside dioleate (120 E.O.), sucrose fatty acid esters, sugar esters such as glyceryl coconut oil fatty acid, lipophilic glycerin monostearate, self-emulsifying glycerin monostearate, polyglycerin monostearate, polyglycerin alkylate, sorbitan monooleate, polyethylene glycol monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylenated sterol, polyoxyethylenated lanolin, polyoxyethylenated hydroxypropyl ester ... Ethylenediamine beeswax, polyoxyethylene hydrogenated castor oil, glycerin fatty acid ester, polyglycerin fatty acid ester (polyglyceryl-10 stearate, polyglyceryl-6 pentastearate), POE sorbitan fatty acid ester, POE sorbit fatty acid ester, POE glycerin fatty acid ester, POE alkyl ether, POE fatty acid ester, POE hydrogenated castor oil, POE castor oil, POE-POP copolymer, POE-POP alkyl ether, polyether-modified silicone lauric acid alkanolamide, alkylamine oxide,Hydrogenated soybean phospholipid, caprylyl glucoside, glyceryl citrate, glyceryl stearate citrate, corn oil PEG-8 esters, cocamide DEA, cocamide MEA, cocamide MIPA, sucrose acetate stearate, hydrogenated palm kernel oil glycerides, hydrogenated palm oil PEG-200 glyceryl, hydrogenated palm oil glycerides, sorbitan sesquiisostearate, polysesquiisostearate Nonionic surfactants such as glyceryl-2, polyglyceryl-2 sesquicaprylate, PEG-20 methyl glucose sesquistearate, sodium stearate, zinc stearate, calcium stearate, magnesium stearate, aluminum stearate, aluminum isostearate, triethanolamine stearate, potassium palmitate, sodium cetyl sulfate, sodium lauryl phosphate, disodium lauryl phosphate, triethanolamine palmitate, polyoxyethylene sodium lauryl phosphate, sodium N-acyl glutamate, sodium palmitate, sodium laurate, potassium laurate, zinc laurate, triethanolamine laurate, sodium laurate, sodium lauryl sulfate, potassium lauryl sulfate, ammonium lauryl sulfate, monoethanolamine lauryl sulfate, diethanolamine lauryl sulfate, triethanolamine lauryl sulfate ethanolamine, sodium lauryldiaminoethylglycinate, triethanolamine ether alkyl sulfate, turmeric oil, linear dodecylbenzene sulfate, polyoxyethylene hydrogenated castor oil maleic acid, acyl methyl taurine, fatty acid soap, α-acylsulfonate, alkyl sulfonate, alkyl aryl sulfonate, alkyl naphthalene sulfonate, alkyl sulfate, POE alkyl ether sulfate, alkyl amide sulfate, alkyl phosphate, POE alkyl phosphate, alkyl amide phosphate, alkyloyl alkyl taurine salt, N-acyl amino acid salt, POE alkyl ether carboxylate, alkyl sulfosuccinate, sodium alkyl sulfoacetate, acyl isethionate, acylated hydrolyzed collagen peptide salt, perfluoroalkyl phosphate ester, soap base, potassium soap, zinc undecylenate, potassium-containing soap base, potassium coconut oil fatty acid, sulfated castor oil,Sodium myristate, potassium myristate, zinc myristate, magnesium myristate, sodium oleate, potassium oleate, triethanolamine N-acyl-L-glutamate, sodium N-acyl-L-glutamate, sodium N-cocoyl-L-glutamate, sodium N-cocoyl / hydrogenated tallow acyl-L-glutamate, triethanolamine N-cocoyl-L-glutamate, disodium stearoyl-L-glutamate, N-hydrogenated tallow acyl-L-glutamate Sodium, N-lauroyl-L-glutamate sodium, N-stearoyl-L-glutamic acid, N-lauroyl-L-lysine, triethanolamine lauroyl-L-glutamate, L-arginine ethyl DL-pyrrolidone carboxylate, N-cocoyl acyl-L-arginine ethyl DL-pyrrolidone carboxylate, cocoyl sarcosine, sodium cocoyl sarcosine, triethanolamine cocoyl sarcosine, lauroyl sarcosine sodium, triethanolamine lauroyl sarcosine , carboxylated polyoxyethylene tridecyl ether sodium salt (3E.O.), sodium beta-laurylaminopropionate, laurylaminopropionic acid solution, potassium coconut oil fatty acid methyl taurate, sodium coconut oil fatty acid methyl taurate, sodium lauroyl methyl taurate, sodium lauryl sulfoacetate, coconut oil fatty acid methyl alanine solution, coconut oil fatty acid triethanolamine solution, sodium lauroyl methyl-beta-alanine solution, lauryl-N-carboxymethoxyethyl-N-carboxymethylimidazolinium di Sodium dodecanoyl sarcosine, coconut oil alkyl-N-carboxyethyl-N-hydroxyimidazolinium betaine sodium, coconut oil alkyl-N-carboxyethoxyethyl-N-carboxyethylimidazolinium disodium hydroxide, coconut oil alkyl-N-carboxymethoxyethyl-N-carboxymethylimidazolinium disodium hydroxide, coconut oil alkyl-N-carboxymethoxyethyl-N-carboxymethylimidazolinium disodium lauryl sulfate, myristoylmethyl-β-alanine sodium solution,Sodium stearoyl methyl taurate, sodium tetradecene sulfonate, sodium dodecylbenzenesulfonate, triethanolamine dodecylbenzenesulfonate, sodium alkane sulfonate, ammonium alkyl sulfate, sodium octylphenoxydiethoxyethyl sulfonate, magnesium triethanolamine cocoate sulfate, sodium myristyl sulfate, sodium cetostearyl sulfate, sodium oleyl sulfate, triethanolamine oleyl sulfate, sodium polyoxyethylene lauryl ether sulfate, ammonium polyoxyethylene lauryl ether sulfate (2E.O.), triethanolamine polyoxyethylene lauryl ether sulfate, ammonium polyoxyethylene alkyl ether sulfate (3E.O.), diethanolamine polyoxyethylene alkyl ether sulfate (3E.O.), triethanolamine polyoxyethylene alkyl ether sulfate (3E.O.), sodium polyoxyethylene alkyl ether sulfate (3E.O.), hydrogenated sodium cocoate glyceryl sulfate, polyoxyethylene (5) monoethanolamine cocoate Amidophosphate ester, polyoxyethylene alkyl (12-14) ether phosphate (2E.O.), (8E.O.), (10E.O.), polyoxyethylene lauryl ether phosphate, sodium polyoxyethylene lauryl ether phosphate, polyoxyethylene cetyl ether phosphate, sodium polyoxyethylene cetyl ether phosphate, polyoxyethylene stearyl ether, polyoxyethylene cholesteryl ether, polyoxyethylene stearyl ether phosphate, polyoxyethylene oleyl ether phosphate, sodium polyoxyethylene oleyl ether phosphate, diethanolamine polyoxyethylene oleyl ether phosphate, polyoxyethylene alkylphenyl ether phosphate, triethanolamine polyoxyethylene alkylphenyl ether phosphate, polyoxyethylene polyoxypropylene cetyl ether phosphate, polyoxypropylene glyceryl ether phosphate, polyoxypropylene butyl ether phosphate, disodium polyoxyethylene lauryl sulfosuccinate, sodium coconut oil fatty acid ethyl ester sulfonate, dioctyl sodium sulfosuccinate,Sodium octylphenoxydiethoxyethyl sulfonate, disodium lauryl sulfosuccinate, disodium oleic acid amide sulfosuccinate, polyoxyethylene alkyl (C12-15) ether phosphate, disodium polyoxyethylene alkyl (C12-14) sulfosuccinate (7E.O.), disodium polyoxyethylene lauroylethanolamide sulfosuccinate (5E.O.), sodium isostearoyl lactylate, sodium undecylenoyl hydrolyzed collagen, potassium undecylenoyl hydrolyzed collagen, sodium undecylhydroxyethylimidazolinium betaine, sodium laurate hydrolyzed collagen, sodium coconut oil fatty acid hydrolyzed collagen, potassium coconut oil fatty acid hydrolyzed collagen, potassium coconut oil fatty acid hydrolyzed collagen solution, triethanolamine coconut oil fatty acid hydrolyzed collagen, isostearoyl hydrolyzed collagen, isostearoyl hydrolyzed silk, isostearoyl hydrolyzed collagen aminomethylpropanediol salt, ethylenediamine-N,N,N',N'-tetrakis(2-hydroxypropyl)dioleate Salt, Dodecanoyl Sarcosine, Sodium Laurylaminodipropionate Solution (30%), Oleoyl Sarcosine, Sodium Myristoyl-β-Alanine Solution, Sodium Undecylhydroxyethylimidazolinium Betaine, Alkyl (C12,13,16) Ammonium Sulfate, Alkyl (C11,13,15) Triethanolamine Sulfate (1), Alkyl (C11,13,15) Triethanolamine Sulfate (2), Alkyl (C12-15) Triethanolamine Sulfate, Alkyl (C12-14) Triethanolamine Sulfate, Alkyl (12,1 3) Sodium sulfate, polyoxyethylene alkyl ether triethanolamine sulfate (3E.O.) solution, (C11-15) Pareth-3 sodium sulfate, (C12,13) ​​Pareth-3 sodium sulfate, (C12-15) Pareth-3 sodium sulfate, (C12,13) ​​Pareth-3 TEA sulfate, (C12,13) ​​Pareth-3 sulfate (TEA / Na), PEG-3 coconut fatty acid amide MEA sodium sulfate, PEG-5 coconut fatty acid amide MEA phosphate, PEG-5 lauryl citrate sulfosuccinate disodium, PEG-5 ceteth-10 phosphate, PEG-25 butyl phosphate,Sodium C14-18 alkyl sulfonate, C20-22 alkyl phosphate, isolaureth-4 phosphate, undecylenoyl glycine, potassium olivate, oleyl sarcosine, sodium methyl oleyl taurate, oleth-3 phosphate, oleth-4 phosphate, oleth-5 phosphate, oleth-10 phosphate, oleth-20 phosphate, sodium oleth-7 phosphate, sodium oleth-8 phosphate, sodium olefin (C14-16) sulfonate, capryloyl glycine, sodium cocoyl amino acids, cocoyl alanine triethanolamine, cocoyl Cocoyl glutamates such as sodium isethionate, ammonium cocoyl isethionate, potassium cocoyl glycinate, sodium cocoyl glycinate, triethanolamine cocoyl glutamate, cocoyl glutamic acid, disodium cocoyl glutamate, potassium cocoyl glutamate, cocoyl sarcosine, sodium cocoyl sarcosine, triethanolamine cocoyl sarcosine, sodium cocoyl taurate, cocoyl methyl alanine, sodium cocoyl methyl alanine, methyl cocoyl taurine, potassium methyl cocoyl taurate, cocoyl methyl alanine, sodium cocoyl methyl alanine, methyl cocoyl taurine, potassium methyl cocoyl taurate, cocoyl sarcosine, sodium cocoyl sarcosine, sodium cocoyl methyl alanine, sodium cocoyl methyl taurine, cocoyl sarcosine, sodium cocoyl methyl taurine, cocoyl sarcosine, sodium cocoyl methyl alanine, sodium cocoyl methyl taurine, potassium cocoyl methyl taurate, cocoyl sarcosine, sodium cocoyl sarcosine, sodium cocoyl methyl alanine, sodium cocoyl methyl taur ...sarcosine, sodium cocoyl methyl alanine, sodium cocoyl methyl taurine, sodium cocoyl Magnesium cocoyl methyl taurate, sodium cocoyl methyl taurate, sodium cocoyl apple amino acids, sodium coceth sulfate, di(C11-15) pareth-2 phosphate, di(C12-15) pareth-4 phosphate, di(C12-15) pareth-8 phosphate, di(C12-15) pareth-10 phosphate, dioleyl phosphate, sodium dioleth-8 phosphate, sodium dioleth-8 phosphate, dicocoyl ethylenediamine PEG-15 sulfate, sodium dilaureth-10 phosphate, steareth-2 phosphate, steareth-3 phosphate, calcium stearoyl lactylate Sodium, Sodium Stearoyl Lactylate, Undecylenamide MEA-2Na Sulfosuccinate, Lauramide MEA-2Na Sulfosuccinate, Disodium Laureth Sulfosuccinate, DEA Cetyl Phosphate, Potassium Cetyl Phosphate, Sodium Cetearyl Sulfate, Ceteth-10 Phosphate, Ceteth-20 Phosphate, Triceteareth-4 Phosphate, Tricedes-4 Carboxylic Acid, Tricedes-8 Carboxylic Acid, Sodium Tricedes-4 Carboxylic Acid, Sodium Tricedes-7 Carboxylic Acid, Sodium Tricedes-3 Acetate, Potassium Tricedes-7 Phosphate, Trilaureth-4 PhosphateOleyl lactate, sodium palmitate glutamate, magnesium palmitoyl glutamate, sodium palmitoyl sarcosinate, palmitoyl proline, sodium palmitoyl proline, sodium palmitoyl methyl taurate, potassium myristoyl glutamate, sodium myristoyl glutamate, sodium myristoyl sarcosinate, sodium myristoyl methyl taurate, potassium cocoate, triethanolamine cocoate, arginine cocoate, sodium lauraminodiacetate, sodium lauryl glycol acetate, laureth-5 carboxylic acid, laureth-6 carboxylic acid, laureth-11 carboxylic acid, sodium laureth-5 carboxylic acid, sodium laureth-6 carboxylic acid, sodium laureth-11 carboxylic acid, laureth-5 acetic acid, laureth-6 acetic acid, laureth anionic surfactants such as potassium ureth-4,5 acetate, sodium laureth-3 acetate, sodium laureth-4 acetate, sodium laureth-5 acetate, sodium laureth-6 acetate, sodium laureth-11 acetate, MIPA laureth sulfate, sodium laureth sulfate, triethanolamine laureth sulfate, ammonium laureth-2 sulfate, ammonium laureth-3 sulfate, laureth-1 phosphate, laureth-2 phosphate, laureth-4 phosphate, sodium lauroyl aspartate, sodium lauroyl oat amino acid, sodium lauroyl lactylate, potassium lauroyl methylalanine, triethanolamine lauroyl methylalanine, dicetyl phosphate, and cetyl phosphate; ammonium chloride, dicocoyl dimethyl ammonium chloride, myristyl dimethyl benzyl ammonium chloride, cetyl trimethyl ammonium chloride, lauryl pyridinium chloride, cetyl pyridinium chloride, benzethonium chloride, stearyl trimethyl ammonium chloride, benzalkonium chloride, benzalkonium chloride solution, lauryl amine oxide, alkyl trimethyl ammonium chloride, stearyl trimethyl ammonium chloride, stearyl dimethyl benzyl ammonium chloride, dimethyl stearyl ammonium chloride treated hectorite, benzyl dimethyl stearyl ammonium chloride treated hectorite, distearyl dimethyl ammonium chloride, distearyl dimethyl ammonium chloride treated bentonite,Dialkyldimethylammonium chloride, tri(polyoxyethylene)stearylammonium chloride (5E.O.), di(polyoxyethylene)oleylmethylammonium chloride (2E.O.), stearoylcholaminoformylmethylpyridinium chloride, polyoxypropylenemethyldiethylammonium chloride, alkyldiaminoethylglycine hydrochloride solution, alkylisoquinolinium bromide solution, lauryltrimethylammonium bromide, cetyltrimethylammonium bromide, stearyltrimethylammonium bromide, cetyltrimethylammonium saccharin, stearyltrimethylammonium saccharin, polyethylene glycol / epichlorohydrin / coconut oil alkylamine / dipropylenetriamine condensate, polyethylene glycol / epichlorohydrin / beef tallow alkylamine / dipropylenetriamine condensate, lanolin fatty acid aminopropylethyldimethylammonium ethyl sulfate (1), (2), behenyltrimethylammonium bromide, behenic acid amidopropyldimethylhydroxypropylammonium chloride, diethylaminoethylamide stearate, dimethylaminopropyl ammonium stearate Ingredients: meadowfoam quaternary ammonium salt, lanolin derivative, PEG-5 oleamine, PEG-2 oleammonium chloride, PEG-2 cocamine, PEG-3 cocamine, PEG-5 cocamine, PEG-10 cocamine, PEG-15 cocamine, PEG-2 dimeadowfoam amidoethylmonium methosulfate, alkyl (C12,14) oxyhydroxypropyl arginine hydrochloride, alkyl (C16,18) trimonium chloride, isoalkyl (C10-40) amidopropyl ethyldimonium ethosulfate, isostearyl ethyl imidazolinium ethosulfate methosulfate, Caesalpinia spinosa hydroxypropyltrimonium chloride, Quaternium-33, Quaternium-91, Cocamidopropyl PG dimonium chloride, Cocamidopropyl betaine amide MEA chloride, Cocoyl arginine ethyl PCA, Cocotrimonium methosulfate, Fenugreek hydroxypropyltrimonium chloride, (myristamide / palmitamide) butylguanidine acetate, Dialkyl (C12-18) dimonium chloride, Dicocoyl ethyl hydroxyethylmonium methosulfate, Dicocodimonium chloride,Distearyldimonium Chloride, Distearoylethyl Hydroxyethylmonium Methosulfate, Dicetyldimonium Chloride, Dipalmitoylethyl Hydroxyethylmonium Methosulfate, Dihydroxypropyl PEG-5 Linoleate Ammonium Chloride, Dimethyl PABA Amidopropyl Laurdimonium Tosylate, Dimethylstearamine, Stearamidoethyl Diethylamine, Stearamidopropyl Dimethylamine, Stearalkonium Chloride, Stearyltrimonium Saccharin, Steartrimonium Chloride, Stearyl Trimonium Bromide, Stearoxypropyltrimonium Chloride, Cetalkonium Chloride, Cetylpyridinium Chloride, Cetrimonium Chloride, Cetrimonium Bromide, Cetrimonium Methosulfate, Soytrimonium Chloride, Palmitamidopropyltrimonium Chloride, Panthenyl Hydroxypropylsteardimonium Chloride, Hydroxyethyl Cetyldimonium Phosphate, Hydroxypropyltrimonium Honey, Hydroxypropyl Bishydroxyethyldimonium Chloride, Behenamidopropyl Dimethylamine, Be Cationic surfactants such as henamidopropyl dimethylamine, behentrimonium chloride, behentrimonium methosulfate, poloxamine 701, poloxamine 702, poloxamine 704, malonic acid bishydroxyethyl cetylamide, coconut oil alkyl PG dimonium chloride sodium phosphate, lauryltrimonium chloride, lauryl pyridinium chloride, linoleamidopropyl PG dimonium chloride phosphate, lauryl dimethylaminoacetic acid betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium Mubetaine, undecyl-N-hydroxyethyl-N-carboxymethylimidazolium betaine, coconut oil alkyl betaine, coconut oil fatty acid amidopropyl betaine, stearyl dihydroxyethyl betaine, stearyl dimethylaminoacetic acid betaine, bis(stearyl-N-hydroxyethylimidazoline) chloroacetic acid complex, coconut oil fatty acid hydrolyzed collagen, oleoyl hydrolyzed collagen, hydrolyzed collagen hexadecyl, lauric acid amidopropyl betaine solution, myristoyl hydrolyzed collagen solution, alkylaminoethylglycine hydrochloride solution,Carboxybetaine type such as lecithin, amidobetaine type, sulfobetaine type, hydroxysulfobetaine type, amidosulfobetaine type, phosphobetaine type, aminocarboxylate type, imidazoline derivative type, amidoamine type, PEG-3 lauramine oxide, oleamine oxide, oleyl betaine, (capryl / capramido)propyl betaine, cocoamine oxide, sodium cocoamphoacetate, sodium cocoamphodiacetate, disodium cocoamphodiacetate, sodium cocoamphopropionate, dihydroxyethyl lauramine oxide, stearamine oxide, stearyl betaine, sodium palm kernel fatty acid amidoethyl hydroxyethylaminopropionate, palm kernel fatty acid amidopropyl betaine, hydroxyalkyl (C12,14) hydroxyethyl Examples of surfactants include amphoteric surfactants such as lauranine, heptadecyl hydroxyethyl carboxylate methyl imidazolinium chloride / heptadecyl bishydroxyethyl imidazolinium, myristamidopropyl betaine, myristamine oxide, myristyl betaine, lauramidopropylamine oxide, lauramidopropyl hydroxysultaine, lauramidopropyl betaine, sodium lauraminopropionate, lauramine oxide, sodium lauriminodipropionate, lauryl hydroxysultaine, lauryl betaine, sodium lauroamphoacetate, and lauroyl lysine; escin, sodium surfactin, saponin, hydroxylated lecithin, hydrogenated lysolecithin, hydrogenated lecithin, cephalin, phosphatidylserine, and water-soluble collagen. One surfactant may be used alone, or two or more may be used in combination.

[0050] Of these surfactants, nonionic surfactants are preferred, such as polyoxyethylene alkyl ethers, polyoxyethylene fatty acid esters, polyoxyethylene sorbitan fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, polyoxyethylene glycerin fatty acid esters, polyoxyethylene hydrogenated castor oil, and polyoxyethylene sorbitol fatty acid esters.

[0051] In particular, for the topical skin preparation according to this embodiment (e.g., cosmetics, particularly lotions), it is preferable to use the following surfactants, which are highly effective in suppressing turbidity and precipitation of cosmetics over time and are widely used in the cosmetics field: L-arginine ethyl DL-pyrrolidone carboxylate, polyoxyethylene glyceryl pyroglutamate isostearate, PEG-9 polydimethylsiloxyethyl dimethicone, sorbitan coconut oil fatty acid, polyoxyethylene polyoxypropylene decyl tetradecyl ether, polyoxyethylene isocetyl ether, polyoxyethylene stearyl ether, polyoxyethylene methyl glucoside, polyoxyethylene lauryl ether, polyoxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil, sorbitan isostearate, polyoxyethylene hydrogenated castor oil isostearate, glycerin fatty acid esters, polyglyceryl diisostearate, sucrose fatty acid esters, sodium stearoyl glutamate, sodium stearoyl lactylate, sorbitan sesquiisostearate, and the like. It is desirable to use at least one surfactant selected from the group consisting of sorbitan, sorbitan sesquioleate, polyoxyethylene alkyl (C12-15) ether phosphate, polyoxyethylene cholesteryl ether, polyoxyethylene cetyl ether phosphate, polyoxyethylene cetostearyl ether, polyoxyethylene phytosterol, polyoxyethylene behenyl ether, polyoxyethylene sorbitan monooleate (20 E.O.), glycerin monostearate, polyethylene glycol monostearate, polyoxyethylene glyceryl monostearate, polyoxyethylene sorbitan monolaurate, dioctyldodecyl lauroyl glutamate, hydrolyzed collagen solution, glyceryl monostearate, hydrogenated soybean lysophospholipid, hydrogenated soybean phospholipid, and water-soluble collagen.

[0052] Furthermore, to improve the quality and stability of the topical skin preparation (e.g., cosmetic product, particularly lotion), the topical skin preparation according to this embodiment may contain at least one selected from the following fragrances, colorants, preservatives, bactericides, ultraviolet absorbers, sequestering agents, and buffering agents. The content of each of these ingredients relative to the topical skin preparation is usually 0.0001% by mass or more, preferably 0.001 to 50% by mass, preferably 0.01 to 25% by mass, and preferably 0.1 to 10% by mass.

[0053] (Fragrance) Examples of fragrances include benzaldehyde, cinnamic aldehyde, cyclamen aldehyde, citral, citronellal, 2-methyl-3-(4-methylphenyl)-propanal, undecenal, methylnonylacetaldehyde, 3,7-dimethyl-1-octanal, hydroxycitronellal, methoxycitronellal, perillaldehyde, myrtenal, caryophyllene aldehyde, n-hexal, 2-methylbutanal, isovaleraldehyde, n-valeraldehyde, acetaldehyde, n-heptanal, n-octanal, n- nonanal, 2-methyloctanal, 3,5,5-trimethylhexanal, 1-decanal, undecanal, dodecanal, 2-methyldecanal, 2-methylundecanal, tridecanal, tetradecanal, 2-pentenal, cis-3-hexenal, trans-2-hexenal, trans-2-heptenal, 4-heptenal, trans-2-octenal, trans-2-nonenal, cis-6-nonenal, 2,6-dimethyl-5-heptenal, trans-4-decenal, cis-4-decenal, trans-2-decenal, 2,5,6-trimethyl-4-heptenal, 10-undecenal, trans-2-undecenal, trans-2-dodecenal, 3-dodecenal, trans-2-tridecenal, 2,6,10-trimethyl-9-undecen-1-al, 2,4-hexadienal, 2,4-heptadienal, 2,4-octadienal, 2,4-nonadienal, 2,6-nonadienal, 2,4-decadienal, 2,4-undecadienal, 2,4-dodecadienal, 5,9-dimethyl-4,8-de Cadienal, 3,7,9-trimethyl-2,6-decadien-1-al, 2,6,10-trimethyl-5,9-undecadienal, α-methylenecitronellal, campholenic aldehyde, cyclocitral, isocyclocitral, 2,6,6-trimethyl-1,3-cyclohexadiene-1-carboxaldehyde, 6,10-dimethyl-3-oxa-9-undecenal, geranyloxyacetaldehyde, dimethyltetrahydrobenzaldehyde, 3-propylbicyclo[2,2,1]-5-heptene-2-carboxaldehyde,Methoxydicyclopentadienecarboxaldehyde, 4-tricyclodecylidenebutanal, 4-(4-methyl-3-cyclohexenylidene-1)pentanal, 4(3)-(4-methyl-3-penten-1-yl)-3-cyclohexene-1-carboxaldehyde, cetanoal, inonal, terrestral, p-tolyl aldehyde, phenylacetaldehyde, 3-phenylbutanal, cumin aldehyde, p-methylphenylacetaldehyde, p-isopropylphenylacetaldehyde, hydratropaldehyde, p-methylhydrat Tropaldehyde, p-isopropylhydratropaldehyde, phenylpropionaldehyde, β-methylhydrocinnamic aldehyde, jasmolandi, bourgeonal, florarozone, suzalal, salicylic aldehyde, anisaldehyde, o-methoxybenzaldehyde, o-methoxycinnamic aldehyde, canthoxal, vanillin, ethyl vanillin, methyl vanillin (3,4-dimethoxybenzaldehyde), helional, phenoxyacetaldehyde, p-methylphenoxyacetaldehyde, furfural, 5-methylfurfural Aldehydes such as cinnamic aldehyde, 5-hydroxymethyl-2-furfural, furyl acrolein, lyral, vernaldehyde, homomylac aldehyde, Junipal, Vertral, Lilial, Meflanal, Eglantal, Cocal, α-methyl cinnamic aldehyde, α-butyl cinnamic aldehyde, α-amyl cinnamic aldehyde, α-hexyl cinnamic aldehyde, formylethyl tetramethyl tetralin, terpinel acetate, vetiveryl acetate, benzyl acetate, linalyl acetate, isopentyl salicylate, benzyl salicylate methyl formate, hexyl salicylate, cis-3-hexenyl salicylate, ethyl formate, cis-3-hexenyl formate, linalyl formate, citronellyl formate, geranyl formate, benzyl formate, phenylethyl formate, ethyl acetate, butyl acetate, isoamyl acetate, methyl cyclopentylideneacetate, hexyl acetate, cis-3-hexenyl acetate, trans-2-hexenyl acetate, isononyl acetate, citronellyl acetate, lavandulyl acetate, geranyl acetate, myrcenyl acetate, terpinyl acetate, menthyl acetate, menthanyl acetate, nopyr acetate, n-bornyl acetate, isobornyl acetatep-t-butylcyclohexyl acetate, o-t-butylcyclohexyl acetate, tricyclodecenyl acetate, 2,4-dimethyl-3-cyclohexene-1-methanyl acetate, phenylethyl acetate, styrallyl acetate, dimethylbenzylcarbinyl acetate, cinnamyl acetate, anisyl acetate, paracresyl acetate, heliotropyl acetate, acetyleugenol, acetylisoeugenol, guaiyl acetate, cedryl acetate, ethyl propionate, isoamyl propionate, citronellyl propionate, geranyl propionate, linalyl propionate, terpinyl propionate Benzyl propionate, cinnamyl propionate, allyl cyclohexylpropionate, tricyclodecenyl propionate, ethyl butyrate, ethyl 2-methylbutyrate, butyl butyrate, isoamyl butyrate, hexyl butyrate, linalyl butyrate, geranyl butyrate, citronellyl butyrate, benzyl butyrate, cis-3-hexenyl isobutyrate, citronellyl isobutyrate, geranyl isobutyrate, linalyl isobutyrate, benzyl isobutyrate, phenylethyl isobutyrate, tricyclodecenyl isobutyrate, ethyl isovalerate, propyl valerate, citronellyl isovalerate, geranyl isovalerate, isovaleryl Benzyl benzoate, cinnamyl isovalerate, phenylethyl isovalerate, ethyl caproate, allyl caproate, ethyl enanthate, allyl enanthate, ethyl caprate, citronellyl tiglate, methyl benzoate, ethyl benzoate, isobutyl benzoate, isoamyl benzoate, geranyl benzoate, linalyl benzoate, benzyl benzoate, phenylethyl benzoate, methyl phenylacetate, ethyl phenylacetate, isobutyl phenylacetate, isoamyl phenylacetate, geranyl phenylacetate, benzyl phenylacetate, phenylethyl phenylacetate, phenyl p-Cresyl acetate, methyl cinnamate, ethyl cinnamate, benzyl cinnamate, cinnamyl cinnamate, phenylethyl cinnamate, methyl salicylate, ethyl salicylate, isobutyl salicylate, amyl salicylate, hexyl salicylate, cis-3-hexenyl salicylate, phenylethyl salicylate, methyl jasmonate, methyl dihydrojasmonate, fulutate, allyl 2-pentyloxyglycolate, ethyl 3-methyl-3-phenylglycidate, ethyl 2-pentanoate, 4-acetoxy-3-amyltetrahydropyran, cyclohexyl salicylate,Esters such as ethyl 2-cyclohexylpropionate, ethyl tricyclo[5.2.1.02,6]decane-2-carboxylate, and 2-methylpentyl 2-methylpentylate, γ-undecalactone, pentalide (cyclopentadecanolide), habanolide (oxacyclohexadecen-2-one), ambrettolide, cyclohexadecanolide, 10-oxahexadecanolide, 11-oxahexadecanolide, 12-oxahexadecanolide, ethylene dodecanedioate, γ-butyrolactone, γ-valerolactone, angelicalactone, γ-hexalactone, γ-heptalactone, γ-octalactone, γ-nonalactone, 3-methyl-4-octalactone, γ-butanol ... Nolide, γ-decalactone, γ-dodecalactone, γ-jasmolactone, jasmine lactone, cis-jasmone lactone, lactojasmone, jasmolactone, menthalactone, n-butylphthalide, propylidenephthalide, butylidenephthalide, δ-hexalactone, δ-octalactone, trivalone, δ-nonalactone, δ-decalactone, δ-2-decenolactone, δ-undecalactone, δ-dodecalactone, δ-tridecalactone, δ-tetradecalactone, lactoscatone (decahydro-4,α-hydroxybenzoate), lactones such as hydroxy-2,8,8-trimethylnaphthalene-2-carboxy acid-δ-lactone), coumarin, dihydrocoumarin, cyclohexyl lactone, 6-methylcoumarin, ε-decalactone, ε-dodecalactone, acetylcaryophyllene, carvone, pulegone, piperitenone, piperitone, camphor, isolongifolaone, nootkatone, 2-heptanone, 2-pentanone, 3-hexanone, 3-heptanone, 4-heptanone, 2-octanone, 3-octanone, 2-nonanone, 3-nonanone, 2-uncleofanone, Decanone, 2-tridecanone, methyl isopropyl ketone, ethyl isoamyl ketone, mesityl oxide, butylideneacetone, methylheptadienone, methylheptenone, dimethyloctenone, 4-methylene-3,5,6,6-tetramethyl-2-heptanone, geranylacetone, farnesylacetone, acetoin, 5-hydroxy-4-octanone, methyl lavender ketone, diacetyl, 2,3-pentadione, 2,3-hexadione, 3,4-hexadione, 2,3-heptadione, acetyl isovaleryl,Amyl cyclopentanone, amyl cyclopentenone, 2-cyclopentyl cyclopentanone, hexyl cyclopentanone, 2-n-heptyl cyclopentanone, cis-jasmone, dihydrojasmone, isojasmone, trimethylpentyl cyclopentanone, sedamone (2-butylidene-3,5,5 (3,3,5)-trimethylcyclopentanone), Sandex, Cyclotene, 3,5-dimethyl-1,2-cyclopentadione, methylcholiron, 2-tert-butylcyclohexanone, p-tert-butylcyclohexanone, 3,3-dimethylcyclopentanone Cyclohexyl methyl ketone, 2-sec-butylcyclohexanone, Artemon, Celery ketone, Krypton, p-tert-pentylcyclohexanone, Methyl cyclocitrone, Neron, 4-cyclohexyl-4-methyl-2-pentanone, Havanol, Maltol, Ethyl maltol, Oxide ketone, Emoxifurone, Homofurol, Sotolon, Furaneol, Acetyldimethylfuran, Furfural acetone, 2-acetyl-5-methylfuran, 2-acetylfuran, Methyltetrahydrofuranone, Dibenzyl ketone, Benzophenone, Methyl naphthyl ketone, 4-damascol, 4-methyl-4-phenyl-2-pentanone), α-methylanisalacetone, heliotropylacetone, anisylideneacetone, anisylacetone, p-methoxyphenylacetone, raspberry ketone, lavandzone, benzylideneacetone, p-methoxyacetophenone, p-methylacetophenone, propiophenone, acetophenone, isodamascone, α-dynascone, iritone, ionone, pseudoionone, methylionone, methyl iritone, 2,4-di-tert-butylcyclohexanone, allyl ionone, 2,6,6-trimethyl-2-cyclohexene-1,4-dione, 2-acetyl-3,3-dimethylnorbornane, Florex, Plicatone, Oxocedrane, Vertofix, Verbenone, Fenchone, Karone, Trimofix O, Epitone, Atrinone, Cashmeran, 3-methylcyclopentadecanone-1, cycloheptadecanone-9-en-1-one, cyclopentadecanone, cyclohexadecenone, Fantolide, 4-acetyl-6-tert-butyl-1,1-dimethylindan, Traseolide, Tonalide, Vitalide, Dihydrocarvone,Ketones such as diosphenol, zingerone, and Iso E Super, phenylacetic acid, sandalole, linalool, musk ketone, methyl ionone, iris oil, iron, indole, ylang-ylang oil, estragole, oakmoss, opoponax resinoid, eugenol, aurantiol, galacsolid, carvacrol, L-carvone, camphor, cannon, carrot seed oil, clove oil, geraniol, geranyl nitrile, sandalwood oil, cyclopentadecanolide, dihydromyrcenol, jasmine absolute, cinnamon bark oil, 1,8-cineole, styrax resinoid, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascone, damascenone, thymol, tuberose absolute, decalactone, terpineol, gamma-terpinene, triplal, 2, 6-Nonadienol, Nonalactone, Patchouli Alcohol, Patchouli Oil, Phenethyl Alcohol, Petitgrain Oil, Cis-3-Hexenol, Balsam of Peru, Vetiver Oil, Vetiverol, Peppermint Oil, Pepper Oil, Heliotropin, Bergamot Oil, Borneol, Myrresinoid, Menthol, L-Menthol, L-Menthone, Eucalyptus Oil, β-Ionone, Lime Oil, Lavender Oil, D-Limonene, Lemon Oil, Rose Absolute, Rose Oxide, Rose Oil, Rosemary oil, Asafoetida resinoid, Ajowan oil, Star anise oil, Abies oil, Amyris oil, Ambrette seed oil, Ambergris tincture, Ylang-ylang absolute, Iris resinoid, Iris absolute, Wintergreen oil, Elemi oleoresin, Elemi resinoid absolute, Elemi tincture, Oakmoss concrete, Oakmoss absolute, Oakmoss resin, Oakmoss resinoid, Ocotea oil, Osmanthus absolute, Osmanthus concrete, Opopanax resinoid, Opopanax absolute, Opopanax oil, Olibanum resinoid, Olibanum absolute, Olibanum oil, Allspice oil, Oregano oil, Oregano resin, Orange flower absolute, Orange flower concrete, Cananga oil, Garjun balsam, Garjun balsam oil, Cascaria bark oil, Castoreum absolute, Cassia absolute, Cassia flower oil,Cassia oil, gardenia absolute, carnation absolute, cabreuva oil, chamomile oil, cardamom oil, galbanum oil, galbanum resin, galbanum resinoid, caraway seed oil, guaiac wood oil, guaiac resin, guaiac concrete, camphor oil, cubeba oil, cumin oil, cumin absolute, cumin oleoresin, clary sage oil, grapefruit oil, costus oil, copaiba balsam, copaiba balsam oil, copaiba balsam resin, coriander oil, sassafras oil, genet absolute, perilla oil, shiso oil Toronella oil, jasmine concrete, juniper berry oil, civet absolute, civet tincture, jonquil absolute, agarwood oil, ginger oil, cinnamon oil, cinnamon leaf oil, cedar oil, styrax oil, spearmint oil, savory oil, sage oil, cedar oil, cedar leaf oil, taget oil, tarragon oil, dill oil, tea tree oil, tree moss absolute, tolu balsam, nutmeg oil, narcissus absolute, neroli oil, violet leaf absolute, pine oil, basil oil, parsley leaf oil, parsley seed Oil, parsley herb oil, peppermint oil, vanilla absolute, honeysuckle absolute, palmarosa oil, valerian oil, bitter orange oil, hyssop oil, cypress oil, hyacinth absolute, fennel oil, fig absolute, buchu oil, pennyroyal oil, peppermint oil, benzoin tincture, benzoin resinoid, bois rose oil, hosho oil, hop oil, hop concrete, hop absolute, marjoram oil, mandarin oil, orange oil, mimosa concrete, mimosa absolute, mimosa oil, mimosa absolute, mimosa Oil, musk absolute, musk tincture, yuzu oil, mugwort oil, labdanum oil, labdanum resinoid, lavender absolute, lavandin oil, lavandin absolute, linaloe oil, lemongrass oil, rose concrete, lovage oil, laurel oil, laurel leaf oil, wormwood oil, musk, spirit cat incense, dragon's oak, sea lion incense, musk Chibata, α-pinene, β-pinene, camphene, myrcene, terpineol, terpinolene, ocimene, γ-terpinene, α-phellandrene, p-cymene, β-caryophyllene, β-farnesene,Hydrocarbons such as 1,3,5-undecatriene and diphenylmethane, anise alcohol, cinnamic alcohol, phenylpropyl alcohol, dimethylbenzyl carbinol, phenylethylmethylethyl carbinol, 3-methyl-5-phenylpentanol, orcinol monomethyl ether, isoeugenol, santalol, isobornylcyclohexanol, sandalore, bagdanol, sandalmysolkha, brahmanol, evanol, polysanthol, 2-ethoxy-4-methoxymethylphenol, trans-2-hexenol, cinnamic alcohol, cinnamic acid, methyl methyl ether ... cis-3-hexenol, 3-octanol, 1-octen-3-ol, 2,6-dimethyl-2-heptanol, 9-decenol, 4-methyl-3-decen-5-ol, 10-undecenol, trans-2-cis-6-nonadienol, nerol, citronellol, rhodinol, myrcenol, lavandulol, tetrahydrogeraniol, tetrahydrolinalool, hydroxycitronellol, alloocimenol, terpinen-4-ol, isopulegol, nopol, farnesol, nerolidol, bisabolol, patchouli alcohol, 2,4 alcohols such as 1-dimethyl-3-cyclohexene-1-methanol, 4-isopropylcyclohexanol, 4-isopropylcyclohexanemethanol 1-(4-isopropylcyclohexyl)-ethanol, 2,2-dimethyl-3-(3-methylphenyl)-propanol, p-t-butylcyclohexanol, o-t-butylcyclohexanol, ambrinol, benzyl alcohol, phenylethyl alcohol, phenoxyethanol, and styrallyl alcohol; methyl dihydrojasmonate; tetrahydrofurfuryl 3-mercaptopropionate; Onate, Cobanol, Geranium Oil, Birch Oil, Almoise Oil, Acetyl Cedrene, Amyl Cinnamaldehyde, Allyl Amyl Glycolate, β-Ionone, Isobutylquinoline, Nerol Oxide, Miloxide, Rose Oxide, Rimetol, Menthofuran, Linalool Oxide, Butyldimethyl Dihydropyran, Acetoxyamyl Tetrahydropyran, Cedryl Methyl Ether, Methoxycyclododecane, 1-Methyl-1-Methoxycyclododecane, Ethoxymethyl Cyclododecyl Ether, Tricyclodecenyl Methyl Ether,Examples of suitable fragrances include ethers such as Rubofix, Cedroxide, Ambroxan, Grisalva, Voisilis, anisole, dimethylhydroquinone, para-cresyl methyl ether, acetanisole, anethole, dihydroanethole, diphenyloxide, methyl eugenol, methyl isoeugenol, benzyl isoeugenol, phenylethyl isoamyl ether, δ-naphthyl methyl ether, δ-naphthyl ethyl ether, δ-naphthyl isobutyl ether, 2,4-dimethyl-4-phenyltetrahydrofuran, galaxolide, and 2,2,5,5-tetramethyl-4-isopropyl-1,3-dioxane, as well as synthetic and natural fragrances such as various essential oils, and various blended fragrances. The fragrances may be used alone or in combination of two or more.

[0054] (Pigments) Pigments include annatto, crocin, capsanthin, shisonin, hibiscus pigment, grapeskin extract, safflor yellow, cacao pigment, laccaic acid, carminic acid, curcumin, betanin, monascorubrin, brazilin, caramel, safflower pigment, gardenia pigment, lithospermum root pigment, and cochineal pigment, as well as anthraquinone, anthocyanin, chalcone, carotenoid, flavonoid, flavin, quinone, porphyrin, diketone, and pentacyanidin pigments. Natural coloring agents such as Photosensitizer No. 101, Photosensitizer No. 201, Photosensitizer No. 301, Photosensitizer No. 401, photosensitizers such as Red No. 2, Red No. 3, Red No. 102, Red No. 104, Red No. 105, Red No. 106, Red No. 201, Red No. 202, Red No. 203, Red No. 204, Red No. 205, Red No. 206, Red No. 207, Red No. 208, Red No. 213, Red No. 214, Red No. 215, Red No. 218, Red No. 219, Red No. 220, Red No. 221, Red No. 223, Red No. 225, Red No. 226, Red No. 227, Red No. 228, Red No. 2 No. 30, Red No. 231, Red No. 232, Orange No. 201, Orange No. 203, Orange No. 204, Orange No. 205, Orange No. 206, Orange No. 207, Yellow No. 4, Yellow No. 5, Green No. 3, Green No. 201, Green No. 202, Green No. 204, Green No. 205, Yellow No. 201, Yellow No. 202, Yellow No. 203, Yellow No. 204, Yellow No. 205, Yellow No. 401, Yellow No. 402, Yellow No. 403, Yellow No. 404, Yellow No. 405, Yellow No. 406, Yellow No. 407, Green No. 401, Green No. 402, Blue No. 403, Purple No. 401, Black No. 401, Blue No. 40 Examples of suitable pigments include organic pigment powders such as zirconium, barium, or aluminum lakes of Red No. 4, Red 401, Red 404, Red 405, Red 501, Red 502, Red 503, Red 504, Red 506, Orange 401, Orange 402, Orange 403, Red 505, and Blue No. 1, Blue 2, Blue 201, Blue 202, Blue 203, Blue 204, Blue 205, Brown 201, and Purple 201, as well as pigments obtained by blending the above organic powders with natural pigments such as Lithospermum rhizome pigments and safflower pigments, or organic synthetic pigments. One type of pigment may be used alone, or two or more types may be used in combination.

[0055] (Preservatives or disinfectants) Examples of preservatives or disinfectants include alkyl esters of parahydroxybenzoates such as phenol, parachlorophenol, parachlorometacresol, parachlorometaxylenol, resorcinol, resorcinol monoacetate, orthophenylphenol, isobutylparaben, ethylparaben, sodium ethylparaben, butylparaben, sodium butylparaben, propylparaben, sodium propylparaben, methylparaben, and sodium methylparaben, phenoxyethanol, thymol, cresol, hinokitiol, and hydroxybenzthiol. phenols such as benzoic acid and its salts, salicylic acid and its salts, sorbic acid and its salts, dehydroacetic acid and its salts, 2,4,4'-trichloro-2'-hydroxydiphenyl ether, halogenated bisphenols such as hexachlorophene, bithionol, and dichlorophene, amides such as 3,4,4'-trichlorocarbanilide, 3-trifluoromethyl 4,4'-dichlorocarbanilide, 3,4',5-tribromosalicylanilide, p-aminobenzenesulfonamide, and undecylenic acid monoethanolamide, benzal chloride, Quaternary ammonium compounds such as benzotriazolium, alkylisoquinolinium bromide, benzethonium chloride, cetylpyridinium chloride, dequalinium chloride, and alkyltrimethylammonium chloride; amphoteric surfactants such as alkylaminoethylglycine chloride and sodium stearylhydroxyethylbetaine chloride; photosensitizers such as chlorhexidine gluconate, tetramethylthiuram disulfide, photosensitizer No. 101, photosensitizer No. 201, photosensitizer No. 301, photosensitizer No. 401, and photosensitizer NK-143; 1-hydroxypyridine-2-thione (zinc pyrithione); ), imidazolidinyl urea, N-trichloromethyl mercapto-4-cyclohexene 1,2-dicarboximide, lysozyme chloride, chlorphenesin, chlorobutanol, 2-bromo-2-nitro-1,3-propanediol, anise oil, sea lion oil, citronellol, eugenol, benzyl alcohol, ethanol, 1,3-butylene glycol, hexylene glycol, dipropylene glycol, glycerin, 1,2-propanediol, 1,2-butanediol, 1,2-pentanediol (pentylene glycol), 1,Alcohols such as 2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, and 1,2-decanediol, parachlormetacresol, chlorhexidine chloride, zinc bis(2-pyridylthio-1-oxide), thianthol, isopropylmethylphenol, 6-acetoxy-2,4-dimethyl-m-dioxane, 5-chloro-2-methyl-4-isothiazolin-3-one, 2-methyl-4-isothiazolin-3-one, chlorine, sodium hypochlorite, bleaching powder, iodine, formaldehyde Examples of antibacterial agents include methyl methyl methacrylate, methyl methacrylate, methyl methacrylate copolymer ... The preservatives or disinfectants may be used alone or in combination of two or more.

[0056] Among the above antibacterial agents, non-parahydroxybenzoic acid ester antibacterial agents such as 1,2-alkanediol and 1,3-butylene glycol are particularly preferred from the viewpoints of low irritation to the skin, high antiseptic effect and moisturizing properties.

[0057] (Ultraviolet Absorber) Examples of the ultraviolet absorber include para-aminobenzoic acid-based ultraviolet absorbers such as para-aminobenzoic acid, para-aminobenzoic acid monoglycerin ester, N,N-dipropoxypara-aminobenzoic acid ethyl ester, N,N-diethoxypara-aminobenzoic acid ethyl ester, N,N-dimethylpara-aminobenzoic acid ethyl ester, and N,N-dimethylpara-aminobenzoic acid butyl ester; anthranilic acid-based ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; cinnamic acid; and oxybenzone-3 benzophenone derivatives such as oxybenzone-4, oxybenzone-5, and oxybenzone-9; sugar-based ultraviolet absorbers in which a sugar or sugar alcohol is bound to a 1,3-propanedione derivative; salicylic acid-based ultraviolet absorbers such as salicylic acid and its sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate, and dipropylene glycol salicylate; Acetate, octyl cinnamate, ethyl 4-isopropyl cinnamate, methyl 2,5-diisopropyl cinnamate, ethyl 2,4-diisopropyl cinnamate, methyl 2,4-diisopropyl cinnamate, propyl p-methoxycinnamate, isopropyl p-methoxycinnamate, isoamyl p-methoxycinnamate, 2-ethylhexyl p-methoxycinnamate, 2-ethoxyethyl p-methoxycinnamate (cinoxate), cyclohexyl Cinnamic acid-based ultraviolet absorbers such as sil-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamate (octocurine), glyceryl mono-2-ethylhexanoyl-di-para-methoxycinnamate, ferulic acid and its derivatives, 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2',4,benzophenone-based ultraviolet absorbers such as 4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, and 4-hydroxy-3-carboxybenzophenone; 3-(4'-methylbenzylidene)-d,l-camphor; , 3-benzylidene-d,l-camphor, 2-phenyl-5-methylbenzoxazole, 2,2'-hydroxy-5-methylphenylbenzotriazole, 2-(2'-hydroxy-5'-t-octylphenyl)benzotriazole, 2-(2'-hydroxy-5'-methylphenylbenzotriazole, dibenzalazine, dianisoylmethane, 5-(3,3-dimethyl-2-norbornylidene)-3-pentan-2-one, 4-methoxy-4'-t-butyldibenzoylmethane, 4-t-butylmethoxydibenzoylmethane and other dibenzoyl compounds. zoylmethane derivatives, octyl triazone, urocanic acid derivatives such as urocanic acid and ethyl urocanate, hydantoin derivatives such as 2-(2'-hydroxy-5'-methylphenyl)benzotriazole, 1-(3,4-dimethoxyphenyl)-4,4-dimethyl-1,3-pentanedione, dimethoxybenzylidene dioxoimidazolidinepropionate octyl, dimethoxybenzylidene dioxoimidazolidinepropionate 2-ethylhexyl, phenylbenzimidazolazole sulfonic acid, terephthalidene dicamphor sulfonic acid, dodecyl benzoate, Examples of ultraviolet absorbers include lometrizole trisiloxane, methyl anthranilate, rutin and its derivatives, oryzanol and its derivatives, octyl dimethyl para-aminobenzoate, titanium oxide, zinc oxide, kaolin, talc, ethylhexyl triazone, octocrylene, dimethyl PABA octyl, homosalate, methylene bisbenzotriazolyl tetramethylbutylphenol, ethylhexyl methoxycinnamate, and octyl methoxycinnamate. One type of ultraviolet absorber may be used alone, or two or more types may be used in combination.

[0058] (Sequestering Agent) Examples of the sequestering agent include ethylenediaminetetraacetic acid (EDTA), ethylenediaminetetraacetates such as EDTA 2Na, EDTA 3Na, and EDTA 4Na, hydroxyethylethylenediaminetriacetates such as hydroxyethylethylenediaminetriacetate trisodium salt, tripolyphosphate, diethylenetriaminepentaacetates, phosphonic acids such as phytic acid and salts thereof such as sodium salts, polyamino acids such as sodium oxalate, polyaspartic acid, and polyglutamic acid, sodium polyphosphate, sodium metaphosphate, phosphoric acid, pyrophosphate, hexametaphosphate, sodium citrate, citric acid, alanine, dihydroxyethylglycine, gluconic acid, succinic acid, and tartaric acid. One type of sequestering agent or ultraviolet absorber may be used alone, or two or more types may be used in combination.

[0059] (Buffering Agent) Examples of buffering agents (pH adjusters) include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, potassium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, boric acid, borax, nitrilotriethanol, monoethanolamine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, ammonium hydroxide, sodium hydroxide, potassium hydroxide, calcium hydroxide, magnesium hydroxide, potassium hydrogen phosphate aqueous ammonia, guanidine carbonate, ammonium carbonate, sodium carbonate, potassium bicarbonate, sodium bicarbonate, magnesium oxide, calcium oxide, ammonium phosphate, sodium monohydrogen phosphate, sodium dihydrogen phosphate sodium phosphate, potassium phosphate, magnesium phosphate, calcium phosphate, sodium borate, sodium metaborate, and potassium citrate. The buffering agent may be used alone or in combination of two or more.

[0060] In particular, for the topical skin preparation according to this embodiment (e.g., a cosmetic product, particularly a lotion), it is desirable to combine at least one buffer selected from sodium citrate, glycolic acid, succinic acid, sodium monohydrogen phosphate, sodium dihydrogen phosphate, sodium hydroxide, and potassium hydroxide, which are commonly used in the field of cosmetics, in an amount sufficient to adjust the pH to within the range of usually pH 5 to 9, preferably pH 6 to 8, and more preferably pH 6.5 to 7.5.

[0061] <Facial Cleanser> The topical skin preparation according to this embodiment can be prepared as a facial cleanser by incorporating a component having a cleansing effect. Dirt on the skin includes dirt caused by the skin's natural physiological functions, i.e., rancid and altered sebum film and peeled stratum corneum, as well as a mixture of dirt such as dust in the air, and everyday cosmetics. Facial cleansers are used almost daily to wash away these and keep the skin clean.

[0062] Specific forms of face washes include, for example, soap, body shampoo, face wash cream, makeup remover, etc. Examples of components having a cleansing effect include alkali salts of higher fatty acids (soap), and alkali salts of higher fatty acids are mainly C １０ ~C １８ Sodium salts, potassium salts, and amine salts of fatty acids.

[0063] To improve and stabilize the quality of the facial cleanser, at least one selected from a fragrance, a colorant, an antioxidant, and a sequestering agent may be further blended, and the content of each of these is typically 0.0001% by mass or more, preferably 0.001 to 50% by mass, preferably 0.01 to 25% by mass, and preferably 0.1 to 10% by mass, relative to the amount of the topical skin preparation. As the fragrance, colorant, and sequestering agent, those described above can be used as appropriate. As the antioxidant, for example, the antioxidants described below can be used as appropriate.

[0064] (Antioxidants) Examples of antioxidants include vitamin A such as retinol, dehydroretinol, retinol acetate, retinol palmitate, retinal, retinoic acid, and vitamin A oil, and derivatives and salts thereof; carotenoids such as α-carotene, β-carotene, γ-carotene, cryptoxanthin, astaxanthin, and fucoxanthin, and derivatives thereof; vitamin B such as pyridoxine, pyridoxal, pyridoxal-5-phosphate, and pyridoxamine, and derivatives and salts thereof; ergocalciferol, cholecalciferol, 1,2,5- Vitamin Ds such as dihydroxy-cholecalciferol, derivatives thereof and salts thereof, vitamin Es such as α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, α-tocotrienol, β-tocotrienol, γ-tocotrienol, δ-tocotrienol, tocopherol acetate, tocopherol nicotinate, derivatives thereof and salts thereof, trolox, derivatives thereof and salts thereof, dihydroxytoluene, butylhydroxytoluene, butylhydroxyanisole, dibutylhydroxytoluene, α-lipoic acid dehydrolipoic acid, glutathione, derivatives thereof and salts thereof, uric acid, erythorbic acid, erythorbic acids such as sodium erythorbate, derivatives thereof and salts thereof, gallic acid, gallic acids such as propyl gallate, derivatives thereof and salts thereof, rutin, α-glycosyl-rutin, and other rutins, derivatives thereof and salts thereof, tryptophan, derivatives thereof and salts thereof, histidine, derivatives thereof and salts thereof, cysteine ​​derivatives such as N-acetylcysteine, N-acetylhomocysteine, N-octanoylcysteine, and N-acetylcysteine ​​methyl ester conductors and their salts, cystine derivatives such as N,N'-diacetylcystine dimethyl ester, N,N'-dioctanoylcystine dimethyl ester, N,N'-dioctanoylhomocystine dimethyl ester and their salts, carnosine and its derivatives and their salts, homocarnosine and its derivatives and their salts, anserine and its derivatives and their salts, carcinine and its derivatives and their salts, dipeptide or tripeptide derivatives containing histidine and / or tryptophan and / or histamine and their salts, flavanones, flavones,Flavonoids such as anthocyanins, anthocyanidins, flavonols, quercetin, quercitrin, myricetin, fisetin, hamamelitannin, catechin, epicatechin, gallocatechin, epigallocatechin, epicatechin gallate, and epigallocatechin gallate, tannic acid, caffeic acid, ferulic acid, protocatechuic acid, chalcone, oryzanol, carnosol, sesamol, sesamin, sesamolin, zingerone, curcumin, tetrahydrocurcumin, clovamide, deoxyclovamide, shogaol, capsaicin, vanillylamide, ellagic acid, bromophenol, flavone, melanoidin, riboflavin, riboflavin butyrate, flavin mononucleotide, flavin ade Examples of antioxidants include ribonucleotides, ubiquinone, ubiquinol, mannitol, bilirubin, cholesterol, ebselen, selenomethionine, ceruloplasmin, transferrin, lactoferrin, albumin, superoxide dismutase, catalase, glutathione peroxidase, metallothionein, thioredoxin, thiotaurine, O-phosphono-pyridoxylidenerhodamine, N-(2-hydroxybenzyl)amino acid, derivatives thereof and salts thereof, N-(4-pyridoxylmethylene)amino acid, derivatives thereof and salts thereof, lysine, l-methionine, proline, silymarin, tea extract, grape bark / seed extract, melanin, rosemary extract, etc. One type of antioxidant may be used alone, or two or more types may be used in combination.

[0065] (Other components) The facial cleanser can further contain at least one component selected from glycerin, ethanol, sugar, polyhydric alcohol and bactericide.As the bactericide, the above-mentioned preservatives and bactericides can be used appropriately, but in the case of soap-based cleansers such as facial cleansers, it is preferable to use chlorhexidine hydrochloride, isopropylmethylphenol, photosensitizer No. 101, cresol, chloroxylenol, thichlorocarbanilide, halocarban, phenol, chlorcresol, phenoxyethanol, trichlorohydroxydiphenyl ether, etc. for the purpose of disinfection, sterilization and deodorization.These may be used alone or in combination of two or more.

[0066] The topical skin preparation according to this embodiment can be prepared as a serum by blending a moisturizer and an emollient. Generally, a serum is a type of cosmetic product that is viscous, has a good feel when used, and has moisturizing properties, unlike a lotion, and has both moisturizing and emollient functions.

[0067] As the moisturizing agent and emollient, those mentioned above can be used as appropriate. Known dosage forms include solubilized type, O / W emulsion type, and oil liquid type.

[0068] Generally, most beauty serums are formulated with at least one selected from the group consisting of fragrances, UV absorbers, whitening agents, anti-inflammatory agents, preservatives, and bactericides, thereby claiming to have functions other than moisturizing and emollient functions. Among the above-mentioned ingredients, the fragrances, UV protection agents, preservatives, and bactericides mentioned above can be used as appropriate. As the whitening agents and anti-inflammatory agents, for example, the following whitening agents and anti-inflammatory agents can be used as appropriate.

[0069] (Whitening Agents) Examples of whitening agents include alkoxysalicylic acids such as 3-methoxysalicylic acid, 3-ethoxysalicylic acid, 4-methoxysalicylic acid, 4-ethoxysalicylic acid, 4-propoxysalicylic acid, 4-isopropoxysalicylic acid, 4-butoxysalicylic acid, 5-methoxysalicylic acid, 5-ethoxysalicylic acid, and 5-propoxysalicylic acid, and salts thereof; hydroquinone, arbutin, α-arbutin, hydroquinone α-L-glucose, hydroquinone β-L-glucose, hydroquinone α-D-galactose, hydroquinone β-D-galactose; Quinone α-L-galactose, hydroquinone β-L-galactose, hydroquinone α-D-ribose, hydroquinone β-D-ribose, hydroquinone α-L-ribose, hydroquinone β-L-ribose, hydroquinone α-D-arabinose, hydroquinone β-D-arabinose, hydroquinone α-L-arabinose, hydroquinone β-L-arabinose, hydroquinone α-D-glucosamine, hydroquinone β-D-glucosamine, hydroquinone α-L-glucosamine, hydroquinone β-L-glucosamine, hydroquinone α Hydroquinones such as uronic acid glycosides such as hydroquinone α-D-galactosamine, hydroquinone β-D-galactosamine, hydroquinone α-L-galactosamine, hydroquinone β-L-galactosamine, hydroquinone α-D-glucuronic acid, hydroquinone β-D-glucuronic acid, hydroquinone α-L-glucuronic acid, hydroquinone β-L-glucuronic acid, hydroquinone α-D-galacturonic acid, hydroquinone β-D-galacturonic acid, hydroquinone α-L-galacturonic acid, hydroquinone β-L-galacturonic acid, and their glycosides derivatives, tranexamic acid and its derivatives and their salts, resorcinol or resorcinol derivatives such as 4-n-butylresorcinol, kojic acid and its derivatives and their salts, ellagic acid, linoleic acid and their salts, anise extract, Japanese knotweed (Japanese yew root) extract, Japanese laurel extract, Siberian laurel extract, Cassia seed extract, Astragalus membranaceus (Astragalus root) extract, Astragalus japonica (Astragalus membranaceus) extract, Common gourd (Callocene gourd) extract, Chinese holly extract, Japanese knotweed extract, Uyghur extract, Pumpkin extract,Cattail extract, Kansui extract, Agrimony extract, Kuromoji extract, Kurokumoso extract, Sisal extract, Sakishima button vine extract, Chinese button vine extract, Chinese lily extract, Oshima cherry extract, Oyama cherry extract, Mame cherry extract, Takane cherry extract, Kohigan extract, Sato cherry extract, Aster extract, Palm extract, White-flowered iris extract, Clematis extract, Tamshiba extract, Daimondjisou extract, Evening primrose extract, Toshishi extract Exudates, bean extract, dodder extract, artemisia absinthium extract, yarrow extract, ringworm extract, dill extract, bee cricket extract, tribulus terrestris extract, stone reed extract, typha extract, angelica extract, floral blanca extract, hamula extract, sea wormwood extract, bindweed extract, sandalwood extract, Ganoderma lucidum extract, betel pulp extract, willow extract, red willow extract, pussy willow extract, corn willow extract, corn willow extract, Willow extract, mountain willow extract, mountain willow extract, willow extract, willow extract, siberian willow extract, foxglove extract, poplar extract, bayberry extract, agave mid-autumn produce, blue agave extract, Fukurin agave extract, Mitsumata extract, green laver extract, thin-striped laver extract, green laver extract, green laver extract, green laver extract, thin-striped laver extract, thin-striped laver extract, kelp extract, Laminaria japonica extract, Laminaria ricinus extract, thin-striped laver extract, Laminaria mitsui extract, wakame extract, Watermelon extract, green seaweed extract, hijiki extract, fucus extract, sea fan extract, pale sea fan extract, yellow sea fan extract, red sea fan extract, Kona sea fan extract, Okinawa fan extract, pale snow fan extract, Euonymus sieboldii extract, thorny ginkgo extract, amakusa ginkgo extract, Euonymus sieboldii extract, juniper ginkgo extract, hornwort extract, hornwort extract, round hornwort extract, Japanese staghorn extract, Japanese seaweed extract, Japanese seaweed extract, Japanese seaweed extract, Japanese seaweed extract, Japanese seaweed extract, Japanese seaweed extract, Japanese seaweed extract,Ishimozuku extract, Misuji Kelp extract, Atsubami Misuji Kelp extract, Isomakura extract, Nagashima Sargassum extract, Shidamoku extract, Nejimoku extract, Narasamo extract, Mametawara extract, Tatsukuri extract, Yatsumatamoku extract, Seaweed extract, Sargassum sieboldii extract, Sargassum sieboldii extract, Centipede extract, Nuraxa extract, Kuronuraxa extract, Centipede extract, Pine extract, Gracilaria sieboldii extract, Spongeweed extract, Fushituna extract, Himefufutuna extract, Broadfushituna extract, Kurosozo extract, Kobusozo extract, Hanesozo extract, Sozonohana Extracts, Hakesa mushroom extract, Tira extract, Camote de Azafran extract, Hamaika extract, Poleo Verde extract, Nabo Negro extract, Sargassum extract, Sargassum serrata extract, Sargassum serrata extract, Sargassum serrata extract, Myrtle extract, Placenta extract, Rucinol, Silk extract, Acacia extract, Acerola extract, Abutilon extract, Weeping birch extract, Quercus gallus extract, Chestnut extract, Camellia sinensis extract, Black-flowered sorghum extract, Sorghum serrata extract, Japanese parsley extract, Buckwheat extract, Durvillea extract, Shepherd's purse Extracts, Fujibakama (Orchid) Extract, Mulberry Extract, Gardenia Extract, Angelica Root Extract, Burnt Leaves Extract, Sophora Angustifolia Extract, Artemisia Princeps Extract, Honeysuckle Extract, Phellodendron Amurense Extract, Houttuynia Cordata Extract, Prunus Armeniaca Extract, Job's Tears Extract, Lamium Extract, Hop Extract, Hawthorn Extract, Eucalyptus Extract, Yarrow Extract, Althaea Officinalis Extract, Cinnamon Bark Extract, Mango Extract, Hamamelis Virginiana Extract, Japanese Mulberry Extract, Platycodon Grandiflorum Extract, Xanthomonas Fruit Extract, Ephedra Extract, Cnidium Rhizome Extract, Bupleurum Root Extract, Saussurea Root Extract, Hamamelis Virginiana Extract Plant extracts such as Safflower extract, Scutellaria root extract, Moutan bark extract, Peony extract, Geranium extract, Kudzu root extract, Licorice extract, Chinese gallnut extract, Aloe extract, Cimicifuga extract, Safflower extract, Green tea extract, Black tea extract, Atractylodes extract, Chamomile extract, Indigo grass extract, Oil-soluble licorice extract, Nishikawa willow extract, and Saxifraga extract, phenylmercury hexachlorophene, mercuric oxide, mercurous chloride, hydrogen peroxide, zinc peroxide, 2-aminophenol and its derivatives, ferulic acid and its derivatives, placenta extract, glutathione, oryzanol,Examples of the whitening agent include butyl resorcinol. One type of whitening agent may be used alone, or two or more types may be used in combination.

[0070] (Anti-inflammatory Agents) Examples of anti-inflammatory agents include propionic acid derivatives such as betamethasone dipropionate, clobetasol propionate, fluticasone propionate, hydrocortisone-21-propionate, hydrocortisone cyclopentylpropionate, and beclomethasone dipropionate; allantoin or derivatives thereof such as allantoin, allantoin acetyl-dl-methionine, allantoin chlorohydroxyaluminum, allantoin dihydroxyaluminum, and allantoin polygalacturonic acid; glycyrrhetinic acid, glycyrrhetinic acid, and glycyrrhetinic acid allantoin. glycyrrhetin or derivatives thereof such as glycerin glycyrrhetinate, stearyl glycyrrhetinate, glycyrrhetinyl stearate, disodium 3-succinyloxyglycyrrhetinate, dipotassium glycyrrhizinate, and monoammonium glycyrrhizinate; pantothenic acid, pantothenyl alcohol (III), pantothenyl ethyl ether, benzoylpantothenyl ethyl ether, calcium pantothenate, sodium pantothenate, acetylpantothenyl ethyl ether, pantothenyl benzoate ethyl ether ester, and pantethine; tocopherol derivatives such as α-tocopherol, β-tocopherol, γ-tocopherol, tocopherol nicotinate, tocopherol acetate, tocopherol linoleate, tocopherol ferulate, tocopherol phosphate esters, tocotrienol, vitamin E or its derivatives such as vitamin E acetate, tocopherol succinate, 2-aminophenol and its derivatives, acetic acid derivatives such as sulindac, diclofenac, fenbufen, pyridoxine hydrochloride, menthol, biotin, camphor, turpentine oil, zinc oxide, azulene , guaiazulene and its derivatives, mefenamic acid and its derivatives, fenamic acid and its derivatives, phenylbutazone and its derivatives, indomethacin and its derivatives, ibuprofen and its derivatives, biphenylcarboxylic acid derivatives, oxicam, salicylic acid, acetylsalicylic acid, naproxen, benoxaprofen, flurbiprofen, fenoprofen, indoprofen, pirprofen, carprofen, oxaprozin, pranoprofen, microprofen, tioxaprofen, suprofen, aluminoprofen, tiaprofenic acid,Fluprofen, ketoprofen and its derivatives, ε-aminocaproic acid, diclofenac sodium, diphenhydramine, tranexamic acid and its derivatives, cortisone and its esters, hydrocortisone and its esters, adrenocortical hormones such as prednisone and prednisolone, antihistamines, bucloxic acid, apazone, bromfenac, celecoxib, difenpyramide, diflunisal, etodolac, flufenamic acid, ketorolac, meclofenamate, mefenamic acid, meloxicam, nabumetone, piroxicam, butibufen , rofecoxib, tolmetin, ketorolac tromethamine, chlorpheniramine, diphenhydramine hydrochloride, chlorpheniramine maleate, corticosteroids, alclometasone, dexamethasone, flumethasone, hydrocortisone, hydrocortisone-21-monoester, hydrocortisone-21-acetate, hydrocortisone-21-butyrate, hydrocortisone-21-valerate, hydrocortisone-17,21-diester, hydrocortisone-17,21-diacetate, hydrocortisone-17-acetate-21-butyrate , hydrocortisone-17,21-dibutyrate, methylprednisolone, betamethasone benzoate, difluorasone diacetate, fluocinonide, mometasone furoate, topical corticosteroids, hydroxytriamcinolone, alpha-methyldexamethasone, dexamethasone phosphate, clobetasol valerate, desonide, desoximetasone, desoxycorticosterone acetate, dichlorisone, diflorasone diacetate, diflucortolone valerate, fluadrenolone, fluchlorolone acetonide, fludrocortisone, flumethasone pivalate, fluocinonide Nolon acetonide, flucortine butyl ester, fluocortolone, fluprednidene acetate (fluprednylidene), flurandrenolone, halcinonide, hydrocortisone acetate, hydrocortisone butyrate, triamcinolone acetonide, cortodoxone, flucetonide, medrysone, amciafer, amcinafide, betamethasone, chloroprednisone, chloroprednisone acetate, clocortelone, clesinolone, difluprednate, flucloronide, flunisolide, fluoromethasone, fluperolone, fluprednisolone, hydrocortisone valerate,Hydrocortamate, meprednisone, paramethasone, triamcinolone, isoxicam, tenoxicam, sudoxicam, CP-14,304, true aloe, plant sterols, phytosterols, indigo grass, Acacia, Hydrangea, Althaea, Arnica, aloe, holly, nettle, angelica, echinacea, emmeiso, turmeric, Scutellaria, barley, St. John's wort, orange, valerian, birch, chamomile, carrot, artemisia capillaris, licorice, cucumber, goldfish, guggal, gardenia, bamboo grass, watercress, gentian, germanium, cola, burdock, comfrey, burdock root, scrophulariaceae, scrophulariaceae extract, salvia, Japanese pepper, cilantro, lithospermum root, perilla, peony, birch, serrulaceae Examples of suitable plants include ginger, St. John's wort, ivy, juniper, yarrow, peppermint, cnidium, Swertia japonica, Sohakuhi, Chinese ginseng, thyme, Chinese parsley, Centella asiatica, chili, peach kernel, Houttuynia cordata, Tormentilla japonica, Polygonum officinalis, tea, Angelica acutiloba, calendula officinalis, elderberry, carrot, parsley, peppermint, sandalwood, loquat, butcher's broom, grape, broccoli, safflower, cinnamon, linden tree, peony, manjistha, horse chestnut, soapberry, goat's milk extract, tradescantia reflexa, evening primrose, peach, cornflower, eucalyptus, mugwort, daylily, lavender, Roman chamomile, and rosemary, or extracts derived from plants, and mixtures thereof. The anti-inflammatory agents may be used alone or in combination of two or more.

[0071] In particular, in the case of the topical skin preparation (particularly a beauty serum) according to this embodiment, it is desirable to use at least one anti-inflammatory agent selected from naturally derived glycyrrhetin or derivatives thereof, such as stearyl glycyrrhetinate and dipotassium glycyrrhizinate, gentian extract, perilla extract, sage extract, elderberry extract, centella asiatica extract, houttuynia cordata extract, angelica extract, peony extract, evening primrose extract, soapberry extract, saxifrage extract, mugwort extract, and apple extract. The content of each of these ingredients relative to the topical skin preparation is usually 0.0001% by mass or more, preferably 0.001 to 50% by mass, preferably 0.01 to 25% by mass, and preferably 0.1 to 10% by mass.

[0072] The topical skin preparation according to this embodiment can be prepared as an emulsion by blending water, an oily component, and a surfactant. The emulsion is used to cleanse, remove makeup, protect, moisturize, and soften the skin, and to promote blood circulation in the skin.

[0073] Except in special cases, emulsions have a smaller amount of oil phase than creams and are fluid emulsions, so they are also known as "liquid creams." Emulsions are either O / W or W / O types, but O / W emulsions are generally used, which have a high proportion of aqueous phase, so when applied to the skin they spread thinly and give a moist feel. The oily components and surfactants can be selected from the above-mentioned components as appropriate.

[0074] The topical skin preparation (particularly the emulsion) according to this embodiment may further contain at least one selected from moisturizers, emollients, blood circulation promoters, and polymeric substances depending on the purpose and function, and the content of each of these is typically 0.0001% by mass or more, preferably 0.001 to 50% by mass, preferably 0.01 to 25% by mass, and preferably 0.1 to 10% by mass, relative to the mass of the topical skin preparation. The moisturizers and emollients may contain the aforementioned components as appropriate. The blood circulation promoters and polymeric substances may contain, for example, the following blood circulation promoters and polymeric substances as appropriate.

[0075] (Blood circulation promoters) Examples of blood circulation promoters include Swertia japonica, carrot (Panax ginseng), ginkgo, nettle, ginger, garlic, Angelica keiskei, arnica, apricot, fennel, emmeisou, St. John's wort, Ononis, Dutch oak, mustard pear, chamomile, Roman chamomile, raspberry, cinchona, gulpin, Sophora flavescens, gentian, kaempferia, watercress, burdock, rice, salvia, Japanese pepper, and hawthorn. , Shiitake mushroom, Rehmannia root, Shibugaki, Peony, Ginger, Calamus, Hawthorn, Horse chestnut, Juniper, Cnidium, Tie dye, Thyme, Clove, Chili pepper, Angelica acutiloba, Calendula, Peach kernel, Spruce, Houttuynia cordata, Jumbo pepper, Mint, Glehnia littoralis, Hamamelis, Butcher's broom, Grape, Lime tree, Hops, Peony, Pine, Horse chestnut, Manchuria Examples of the blood circulation promoter include substances derived from plants such as laurel wort, melissa officinalis, melilot, yuzu, loquat, coix seed, lavender, gentian, rosemary, rose hip, tangerine peel, peach, walnut, horsetail, calamus root, aloe, bayberry, eucalyptus, and mugwort, hesperidin, transglycosyl hesperidin, rutin, transglycosyl rutin, acetylcholine, carpronium chloride, diphenhydramine hydrochloride, γ-oryzanol, 1-menthol, cepharanthine, vitamin E, δ-tocopherol, α-tocopherol, tocopherol acetate, tocopherol linoleate, methyl nicotinate, tocopherol nicotinate, tocopherol succinate, vitamin E derivatives such as vitamin E nicotinate, minoxidil, nicotinamide, nonylic acid vanillylamide, and carbon dioxide. One type of blood circulation promoter may be used alone, or two or more types may be used in combination.

[0076] (Polymer Substance) In the case of emulsions, a polymer substance is generally added in advance to the aqueous phase for the purpose of a protective colloid, and examples of the polymer substance include carboxyvinyl polymer, xanthan gum, acrylic polymer, sodium carboxymethyl cellulose (CMC), etc. One type of polymer substance may be used alone, or two or more types may be used in combination.

[0077] <Cream> The topical skin preparation according to this embodiment can be prepared as a cream by blending water, an oily component, and a surfactant. Similar to emulsions, there are two types of emulsions: O / W and W / O. However, creams generally contain a larger amount of oil phase than emulsions, making them non-fluid emulsions. The purpose of creams, like emulsions, is to cleanse the skin, remove makeup, protect the skin, moisturize and soften it, and promote blood circulation in the skin. More specific examples of creams include cleansing creams, emollient creams, nourishing creams, night creams, base creams, vanishing creams, moisture creams, massage creams, cold creams, and lip creams.

[0078] The oily component and surfactant used in the cream can be the same as those described above. The cream can further contain, as an auxiliary component to the oily component, at least one selected from spermaceti, cetanol, lanolin, liquid paraffin, petrolatum, glycerin, and squalane, and the content of each of these components relative to the external skin preparation is usually 0.0001% by mass or more, preferably 0.001 to 50% by mass, preferably 0.01 to 25% by mass, and preferably 0.1 to 10% by mass.

[0079] <Other Components> In addition to the various components described above, the topical skin preparation according to this embodiment may contain other commonly used components as needed, such as the following thickeners, vitamins, amino acids, anti-wrinkle agents, seaweed extracts, cell activators, transdermal absorption promoters, foaming agents, solubilizers, keratolytic agents, hormones, pigments, plasticizers, inorganic powders, or organic powders. These may be used alone or in combination of two or more.

[0080] (Thickeners) Examples of thickeners include guar gum, locust bean gum, queen seed, carrageenan, galactan, gum arabic, tara gum, tamarind, furcellaran, karaya gum, aloysia laurel, caragam, tragacanth gum, pectin, pectinic acid and salts such as sodium salt, alginic acid and salts such as sodium salt, mannan, starch such as rice, corn, potato, and wheat, dextrin, xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and salts thereof, xanthan gum, pullulan, and gellan gum. , chitin, chitosan, agar, cassou extract, chondroitin sulfate, casein, collagen, gelatin, albumin, methyl cellulose, ethyl cellulose, hydroxypropyl cellulose, hydroxyethyl cellulose, carboxymethyl cellulose and its sodium salts, methylhydroxypropyl cellulose, sodium cellulose sulfate, dialkyldimethylammonium cellulose sulfate, crystalline cellulose, cellulose powder and other cellulose and its derivatives, soluble starch, carboxymethyl starch, methylhydrogen cellulose, cellulose esters ... starch-based polymers such as hydroxypropyl starch and methyl starch, starch derivatives such as hydroxypropyltrimonium starch chloride and corn starch aluminum octenylsuccinate, alginic acid derivatives such as propylene glycol alginate, polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), vinylpyrrolidone-vinyl alcohol copolymer, vinyl alcohol-vinyl acetate copolymer, polyvinyl methyl ether, polyethylene glycol, polypropylene glycol, polyoxyethylene-polyoxypropylene copolymer, amphoteric methacrylate ester copolymers such as (methacryloyloxyethyl carboxybetaine / alkyl methacrylate) copolymer, (acrylates / stearyl acrylate / ethylamine oxide methacrylate) copolymer, (dimethicone / vinyl dimethicone) crosspolymer, (alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP, partially saponified polyvinyl acetate, maleic acid copolymer, polyvinylpyrrolidone,vinylpyrrolidone-dialkylaminoalkyl methacrylate copolymer; acrylic resin alkanolamine, polyester, water-dispersible polyester, polyacrylamide, polyacrylic acid ester copolymers such as ethyl polyacrylate, carboxyvinyl polymer, polyacrylic acid and its salts such as sodium salt, acrylic acid-methacrylic acid ester copolymer, acrylic acid-alkyl methacrylate copolymer, cationized cellulose such as Polyquaternium-10, diallyldimethylammonium chloride-acrylamide copolymer such as Polyquaternium-7, acrylic acid-diallyldimethylammonium chloride copolymer such as Polyquaternium-22, acrylic acid-diallyldimethylammonium chloride-acrylamide copolymer such as Polyquaternium-39, acrylic acid-cationized methacrylic acid ester copolymer, acrylic acid-cationized methacrylic acid amide copolymer, acrylic acid-methyl acrylate-methacrylamidopropyltrimethylammonium chloride copolymer such as Polyquaternium-47, methacrylic acid chloride choline ester polymer, cationized oligosaccharide, cationized dextran, guar Cationic polysaccharides such as hydroxypropyltrimonium chloride, polyethyleneimine, cationic polymers, 2-methacryloyloxyethyl phosphorylcholine polymers such as polyquaternium-51 and copolymers with butyl methacrylate copolymers, acrylic resin emulsions, polyethyl acrylate emulsions, polyacrylic alkyl ester emulsions, polyvinyl acetate resin emulsions, polymer emulsions such as natural rubber latex and synthetic latex, nitrocellulose, polyurethanes and various copolymers, various silicones, various silicone copolymers such as acrylic-silicone graft copolymers, various fluorine-based polymers, 12-hydroxystearic acid and its salts, dextrin fatty acid esters such as dextrin palmitate and dextrin myristate, cholesteryl hydroxystearate, silicic anhydride, fumed silica (ultrafine particle silicic anhydride), aluminum magnesium silicate, sodium magnesium silicate, metal soaps, dialkyl phosphate metal salts, bentonite, hectorite, organically modified clay minerals, sucrose fatty acid esters, fructooligosaccharide fatty acid esters, quince seed extract,Examples of the thickener include natural polymers, semi-synthetic polymers, and synthetic polymers such as hydroxyethyl guar gum, carboxymethyl guar gum, starch, carboxymethyl chitin, and carboxymethyl starch. One type of thickener may be used alone, or two or more types may be used in combination.

[0081] (Vitamins) Examples of vitamins include vitamin A and derivatives thereof such as retinol, retinol acetate, and retinol palmitate, thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, flavin adenine dinucleotide, cyanocobalamin, folic acids, nicotinic acids such as nicotinamide and benzyl nicotinate, cholines, vitamin B6 hydrochloride, vitamin B6 tripalmitate, vitamin B6 dioctanoate, vitamin B12, vitamin B2, vitamin B6, vitamin B15, and derivatives thereof. Examples of vitamins include tocopherol derivatives such as α-tocopherol, β-tocopherol, γ-tocopherol, tocopherol nicotinate, tocopherol acetate, tocopherol linoleate, tocopherol ferulate, and tocopherol phosphate, vitamin E derivatives such as tocotrienol, vitamin E acetate, and tocopherol succinate, vitamin D derivatives, vitamin H, pantothenic acid, pantethine, vitamin F, vitamin K, and vitamin P, and flavonoids and derivatives thereof, vitamin U, ferulic acid, γ-oryzanol, α-lipoic acid, orotic acid, coenzyme Q10, and biotin. One type of vitamin may be used alone, or two or more types may be used in combination.

[0082] (Amino Acids) Examples of amino acids include valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine, taurine, carnitine, etc., as well as sulfates, phosphates, nitrates, citrates thereof, pyrrolidone carboxylic acid, and derivatives thereof, etc. One type of amino acid may be used alone, or two or more types may be used in combination.

[0083] (Anti-wrinkle agents) Examples of anti-wrinkle agents include glycerin, vitamin A or a derivative thereof, glycolic acid, acylated glucosamine, kinetin, vitamin E or a derivative thereof, aloe extract, collagen, hyaluronic acid, peptides such as tripeptides and tetrapeptides, seaweed extract, horse chestnut extract, rosemary extract, cornflower extract, trehangerin, glucosylnaringin, etc. One type of anti-wrinkle agent may be used alone, or two or more types may be used in combination.

[0084] (Seaweed extract) Examples of seaweed extracts include extracts from brown algae, red algae, green algae, blue-green algae, etc. Specific examples include extracts from kelp, Laminaria japonica, wakame, hijiki, Agar, Coralline algae, Palmaria, Hornwort, Nori, Ulva, Ulva pertusa, Ascophyllum, Fucus, Mozuku, Cladosiphon okamuranus, Himantaria, etc. Extracts from aquatic plants such as Zostera marina may also be included. Seaweed extracts may be used alone or in combination of two or more.

[0085] (Cell activators) Examples of cell activators include extracts of plants such as whey, arnica, Phellodendron bark, chlorella, hops, and turnip, amino acids such as γ-aminobutyric acid and ε-aminoproic acid, vitamins such as retinol, thiamine, riboflavin, pyridoxine hydrochloride, and pantothenic acids, α-hydroxy acids such as glycolic acid and lactic acid, flavonoids, saponin, allantoin, photosensitizer No. 101, photosensitizer No. 301, photosensitizer No. 401, and NK-4. One type of cell activator may be used alone, or two or more types may be used in combination.

[0086] (Transdermal absorption enhancer) Examples of the transdermal absorption enhancer include urea, lactic acid, fruit acid, α-hydroxy acids such as glycolic acid, β-hydroxy acids such as salicylic acid, oleic acid, undecanoic acid, octanol, nonanol, menthol, thymol, limonene, dimethyl sulfoxide, dodecyl methyl sulfoxide, dimethylacetamide, N,N-dimethylformamide, sodium lauryl sulfate, N,N-bis(2-hydroxyethyl)oleylamine, polyoxyethylene(20)sorbitan monooleate, dodecyl diol, methylpropional ... Examples of the percutaneous absorption enhancer include methylammoniopropanesulfonic acid, propylene glycol, polyethylene glycol, n,n-dimethyl-m-toluamide, diethyl-m-toluamide, laurocapram, 1-dodecylazacycloheptan-2-one, isopropyl myristate, isopropyl palmitate, N-mono- or di-substituted-p-menthane-3-carboxamide, 2-(2-methoxy-1-methylethyl)-5-methylcyclohexanol, azacycloalkane derivatives, cyclodextrin, etc. One type of percutaneous absorption enhancer may be used alone, or two or more types may be used in combination.

[0087] (Blowing Agent) Examples of the blowing agent include azodicarbonamide, barium azodicarboxylate, azobisisobutyronitrile, azodicarboxylic acid amide, N,N'-dinitrosopentamethylenetetramine, N,N'-dimethyl-N,N'-dinitrosoterephthalamide, trinitrotrimethyltriamine, 4,4'-oxybis(benzenesulfonylhydrazide), paratoluenesulfonylhydrazide, diphenylsulfone-3,3'-disulfonylhydrazide, allylbis(sulfonylhydrazide), p-toluylenesulfonylsemicarbazide, 4,4'-oxybis(benzenesulfonylsemicarbazide), fluorinated alkanes such as trichloromonofluoromethane and dichloromonofluoromethane, 5-morpholyl-1,2,3,4-thiatriazole, ammonium carbonate, ammonium hydrogencarbonate, sodium hydrogencarbonate, ammonium nitrite, sodium borohydride, and azides. The foaming agent may be used alone or in combination of two or more.

[0088] (Solubilizer) Examples of the solubilizer include polyols such as ethanol, phenoxyethanol, isopropanol, butyl alcohol, benzyl alcohol, lauryl alcohol, myristyl alcohol, cetyl alcohol, cetostearyl alcohol, stearyl alcohol, oleyl alcohol, behenyl alcohol, ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, glycerin, diglycerin, polyglycerin, glycerin monostearate, isoprene glycol, 1,2-butanediol, 1,3-butanediol, 1,4-butanediol, 2,3-butanediol, 1,2-pentanediol, 1,5-pentanediol, 2,3-pentanediol, 2,4-pentanediol, sorbitol, malbitol, raffinose, hexylene glycol, lauric acid diethanolamide, and fatty acid diethanolamide; polyoxyethylene alkylphenyl ether; polyoxyethylene alkyl ether; Examples of solubilizers include cationic surfactants such as ether, polyoxyethyleneoleyl alcohol ether, polyoxyethylene polyhydric alcohol fatty acid ester, polyoxyethylene hydrogenated castor oil, polyhydric alcohol fatty acid ester, ethylene glycol fatty acid ester, polyglycerin fatty acid ester, sucrose fatty acid ester, and tetraalkylammonium salt; anionic surfactants such as alkyltrimethylammonium salt, alkylpyridinium chloride, stearyltrimethylammonium chloride, fatty acid salt, alkyl sulfate, alkyl ether sulfate ester salt, alkyl triethanolamine sulfate, polyoxyethylene sodium lauryl sulfate, sodium lauryl sulfate, and sodium lauroyl glutamate; amphoteric surfactants such as betaine-type surfactants (e.g., lauryldimethylaminoacetic acid betaine), sulfobetaine-type surfactants, and sulfoamino acid-type surfactants; silicone-based surfactants such as polyether-modified silicone and amino-modified silicone; and natural surfactants such as lecithin, lysophosphatidylcholine, ceramide, cerebroside, and sodium surfactin. One solubilizer may be used alone, or two or more may be used in combination.

[0089] (Keratolytic Agent) Examples of keratolytic agents include glycolic acid, tartaric acid, salicylic acid, citric acid, lactic acid, pyruvic acid, gluconic acid, glucuronic acid, malic acid, oxalic acid, malonic acid, succinic acid, acetic acid, phenol, resorcinol, retinoic acid, adapalene, trichloroacetic acid, 5-fluorouracil, azelaic acid, etc. One type of keratolytic agent may be used alone, or two or more types may be used in combination.

[0090] (Hormones) Examples of hormones include estradiol, estrone, ethinylestradiol, cortisone, hydrocortisone, prednisolone, cholecalciferol, estrogen, pregnenolone, adrenocortical hormones, etc. One type of hormone may be used alone, or two or more types may be used in combination.

[0091] (Pigments) Examples of pigments include extender pigments such as talc, kaolin, mica, sericite, calcium carbonate, magnesium carbonate, magnesium silicate, and silicic anhydride, white pigments such as titanium oxide and zinc oxide, colored pigments such as yellow iron oxide, red iron oxide, black iron oxide, ultramarine, ferric iron oxide, chromium oxide, chromium hydroxide, and carbon black, pearl pigments such as fish scale foil, bismuth oxychloride, titanium mica, and titanium colored mica, and powder pigments such as magnesium, calcium, and aluminum stearates, zinc salts of lauric acid, palmitic acid, and myristic acid, starch powder, silk powder, nylon powder, polymethyl methacrylate powder, and polyethylene powder. One type of pigment may be used alone, or two or more types may be used in combination.

[0092] (Plasticizer) Examples of the plasticizer include dibutyl phthalate, dioctyl phthalate, acetyltributyl citrate, camphor, etc. One type of plasticizer may be used alone, or two or more types may be used in combination.

[0093] (Inorganic Powder) Examples of inorganic powders include calcium hydrogen phosphate, organically modified montmorillonite, silicic acid, silicic anhydride, magnesium silicate, mica, bentonite, titanium-coated mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, calcium carbonate, magnesium carbonate, iron oxide, ultramarine, Prussian blue, chromium oxide, calamine, zeolite, and carbon black. One type of inorganic powder may be used alone, or two or more types may be used in combination.

[0094] (Organic Powder) Examples of organic powders include polyamide, polyester, polyethylene, polypropylene, polystyrene, polyurethane, vinyl resin, urea resin, phenolic resin, fluororesin, silicone resin, acrylic resin, melamine resin, epoxy resin, polycarbonate resin, divinylbenzene-styrene copolymer, copolymers of two or more of the monomers of the above compounds, cellulose, etc. One type of organic powder may be used alone, or two or more types may be used in combination.

[0095] (Other Ingredients) The topical skin preparation according to this embodiment (for example, lotion, facial cleanser, serum, emulsion, or cream) may further contain, in addition to the above, antibiotics, transglycosyl glycyrrhizin, glycyrrhizin, alpine rose extract, Crocus chrysanthus extract, millet seed extract, pomegranate flower extract, Alpinia katsumadai seed extract, Kurotumpaki fruiting body extract, Magnolia obovata extract, Nannochloropsis extract, Terminalia bellirica extract, Vibrio alginolyticus fermentation (culture) solution, Artemia extract, hybrid rose flower extract, human oligopeptide, Aureobasidium nigricans extract, Saccharomyces pullulans ferment broth, Aspergillus / chestnut astringent skin fermentation extract, Alteromonas fermentation extract, hydrolyzed yeast extract, yeast extract, yeast polysaccharides, rice fermentation broth, Thermus thermophilus ferment, sake lees extract, Saccharomyces / Ca ferment, Saccharomyces / K ferment, Saccharomyces / Mg ferment, Saccharomyces / Zinc ferment, Saccharomyces / sea salt ferment, (Saccharomyces xylinum) / black tea ferment, Saccharomyces / silicon ferment, Saccharomyces / germanium ferment, Saccharomyces cerevisiae extract, Saccharomyces / selenium ferment Saccharomyces / iron culture, Saccharomyces / copper culture, Saccharomyces culture lysate, Saccharomyces / manganese culture, Saccharomyces lysate extract, Pseudoalteromonas ferment extract, Sclerotium gum, Sphingomonas extract, soybean ferment extract, soy milk ferment filtrate, Lactobacillus / Eriodictyon californicum ferment extract, Lactobacillus / olive leaf ferment extract, Lactobacillus / cocoa fruit ferment filtrate, Lactobacillus / quinoa ferment extract, Lactobacillus / rice ferment extract, Lactobacillus / pear juice ferment filtrate, Lactobacillus / soybean ferment extract, Lactobacillus / tomato extract Tomato fermented extract, Lactobacillus / date palm fruit fermented extract, Lactobacillus / (milk / Ca / phosphorus / Mg / zinc) fermented product, Lactobacillus / hibiscus flower fermented filtrate, Lactobacillus / (bean seed extract / sodium glutamate) fermented filtrate, Lactobacillus / grape juice fermented filtrate, Lactobacillus / Cucurbita pepo fruit fermented extract, Lactobacillus / (lychee extract / shiitake mushroom extract) fermented filtrate, Lactobacillus / lemon peel fermented extract, Lactobacillus / wasabi root fermented extract, Lactococcus culture filtrate, Bacillus / (rice bran extract / soybean extract) fermented filtrate, Bacillus fermented product, Bifidobacterium fermented extract, Micrococcus lysate,Yogurt liquid, Ranela / soy protein fermentation product, wine extract, gelatinous substance derived from stinkhorn mushroom, the main component of which is an acidic polysaccharide consisting of a trisaccharide unit consisting of linked β-D-glucuronic acid, α-L-iduronic acid, and β-D-glucuronic acid, sunflower sprout extract, jackfruit (seed) extract, longan extract, Acmella japonica extract, Apple extract, Phyllosinca extract, pelargonidin extract, kinetin, glycylproline, ethylhexylglycerin, ethoxydiglycol, oleyl glyceryl, gluconolactone, dicaprylyl ether Ethers and ketones such as ether, dihydroxyacetone, panthenyl ethyl, hydroxyalkyl (C16-18) hydroxydimer dilinoleyl ether, hydroxyalkyl (C12-14) hydroxydimer dilinoleyl ether, methoxyethanol, asiatic acid, alluritic acid, sodium ursolate, oleanolic acid, guanidine hydrochloride, aluminum citrate, sodium citrate, diammonium citrate, tri(tetramethylhydroxypiperidinol) citrate, sodium succinylglycyrrhetinate, dithioglycerin Organic acids or salts thereof such as cholic acid, MEA dithioglycolic acid, diammonium dithiodiglycolate, sebacic acid, thioglycolic acid, MEA thioglycolic acid, ammonium thioglycolate, thiolactic acid, ammonium thiolactate, calcium pantetheine sulfonate, calcium propionate, sodium propionate, pentetic acid, pentasodium pentetate, and madecassic acid; amines such as aminomethylpropanol, aminomethylpropanediol, diisopropanolamine, cysteamine hydrochloride, and tetrahydroxypropylethylenediamine; , deoxyribonucleic acid (DNA), deoxyribonucleic acid potassium salt, ribonucleic acid (RNA), ribonucleic acid sodium salt, almond protein, aspartame, adenosine phosphate, adenosine phosphate disodium, alanyl glutamine, (arginine / lysine) polypeptide, undecylenoyl phenylalanine, oligopeptide-6, ornithine hydrochloride, hydrolyzed DNA, hydrolyzed RNA, hydrolyzed almond protein, hydrolyzed actin, hydrolyzed elastin, hydrolyzed casein, hydrolyzed oat protein, hydrolyzed keratin, hydrolyzed yeast protein,Hydrolyzed rice protein, hydrolyzed conchiolin, hydrolyzed silk, hydrolyzed white lupin protein, hydrolyzed soy protein, hydrolyzed corn protein, hydrolyzed milk protein, hydrolyzed honey protein, hydrolyzed hazelnut protein, hydrolyzed jojoba protein, hydrolyzed vegetable protein, hydrolyzed royal jelly protein, oat kernel protein, milk glycoprotein, disodium guanylate, creatine, keratin, wheat gluten, wheat protein, sarcosine, citrulline, dipalmitoyl hydroxyproline, dipeptide Proteins and nucleic acids such as hexapeptide-2, sericin, soy protein, hexapeptide-2, hexapeptide-3, hexapeptide-9, hexapeptide-10, hexapeptide-11, pentapeptide-3, whey protein, enzymes such as coenzyme A, styrene, papain, protease, bromelain, lipase, α-glucosidase, terpenes such as menthone glycerin acetal, (C30-38 olefin / isopropyl maleate / maleic acid) copolymer, (HDI / PPG / polycaprolactone) crosspolymer, PEG- Polyethylene glycols such as PEG-4, PEG-6, PEG-8, PEG-12, PEG-16, PEG-20, PEG-30, PEG-32, PEG-40, etc., propylene oxide polymers or derivatives thereof such as PPG-3, PPG-7, etc., (VA / crotonic acid / vinyl neodecanoate) copolymer, (VP / DMAPA acrylate) copolymer, (VP / vinyl caprolactam / DMAPA acrylate) copolymer, (VP / methacrylamide / vinylimidazole) copolymer, (acrylamide / ammonium acrylate) copolymer, (acrylamide (acrylic acid / sodium acryloyldimethyl taurate / acrylic acid) copolymer, (acrylamide / sodium acryloyldimethyl taurate) copolymer, (sodium acrylate / sodium acryloyldimethyl taurate) copolymer, (sodium acrylate / acryloyldimethyl taurate) copolymer, (acrylic acid / acrylamidomethylpropanesulfonic acid) copolymer, (acrylic acid / alkyl acrylate (C10-30)) copolymer, (acrylamidopropyltrimonium chloride / acrylic acid amide) copolymer,(Alkyl acrylate / octylacrylamide) copolymer, alkyl acrylate copolymer or derivatives thereof, (alkyl acrylate / diacetoneacrylamide / amodimethicone) copolymer AMP, (alkyl acrylate / diacetoneacrylamide) copolymer, (alkyl acrylate / diacetoneacrylamide) copolymer AMP, (alkyl acrylate / diacetoneacrylamide) copolymer AMPD, (hydroxyethyl acrylate / butyl acrylate / methoxyethyl acrylate) copolymer, (hydroxyethyl acrylate / methoxyethyl acrylate) copolymer, (hydroxyethyl acrylate / sodium acryloyldimethyltaurate) copolymer, (acrylates / acrylamide) copolymer, (acrylates / C10-30 alkyl acrylate) crosspolymer, (acrylates / alkylstearyl acrylate / ethylamine oxide methacrylate) copolymer, (acrylates / hydroxyalkyl acrylate) copolymer, acrylates copolymer, carbomer, (ethylene / propylene) copolymer, (ethylene / propylene / styrene) copolymer polymers, (octylacrylamide / hydroxypropyl acrylate / butylaminoethyl methacrylate) copolymers, synthetic waxes, hydrogenated C16-14 olefin polymers, (butylene / ethylene / styrene) copolymers, polyacrylamide, sodium polyacrylate, polyethylene isoterephthalate, polyoctaniums such as polyoctanium-5, polyoctanium-6, polyoctanium-7, polyoctanium-11, polyoctanium-16, polyoctanium-22, polyoctanium-28, and polyoctanium-32, polyglycerides, Synthetic polymer compounds such as glycerol, polydecene, polypropylsilsesquioxane, polyglyceryl methacrylate, polymethacryloylethyl betaine, polymethacryloylethyl betaine, and Repagermanium; acetyl dipeptide-1 cetyl, acetyl tetrapeptide-2, acetyl tetrapeptide-5, acetyl hexapeptide-1, acetyl hexapeptide-3, and sodium isoalkyl (C8-16) succinate lactoglobulin sulfonate; and other skin care products that can be generally used in cosmetics and other skin care products.In addition to the above, existing cosmetic raw materials can also be used. These may be used alone or in combination of two or more.

[0096] For example, "Annotated Standards for Cosmetic Ingredients, Second Edition," edited by the Japan Compendium Association, published by Yakuji Nipposha Co., Ltd. in 1984; "Standards for Ingredients Other Than the Standards for Cosmetic Ingredients," supervised by the Inspection Division of the Pharmaceutical Affairs Bureau, Ministry of Health and Welfare, published by Yakuji Nipposha Co., Ltd. in 1993; "Supplement to the Standards for Ingredients Other Than the Standards for Cosmetic Ingredients," supervised by the Inspection Division of the Pharmaceutical Affairs Bureau, Ministry of Health and Welfare, published by Yakuji Nipposha Co., Ltd. in 1993; "Approval Standards for Cosmetics by Type," supervised by the Inspection Division of the Pharmaceutical Affairs Bureau, Ministry of Health and Welfare, published by Yakuji Nipposha Co., Ltd. in 1993; All cosmetic raw materials described in "The Latest Cosmetic Science - Revised and Enlarged II" edited by the Association of Japanese Cosmetic Chemists and published by Yakuji Nippo Co., Ltd. in 1992, "Cosmetics Encyclopedia" edited by the Association of Japanese Cosmetic Chemists and published by Maruzen Co., Ltd. in 2003, and "Japanese Cosmetic Raw Materials Collection 2007" edited by the Japan Cosmetic Industry Association and published by Yakuji Nippo Co., Ltd. in 2007, etc., can be used in appropriate combination.

[0097] In this specification, external use means contacting a composition with a desired skin site on a human or the like, and allowing the active ingredient contained in the composition to penetrate into the epidermis, dermis, and / or subcutaneous tissue. The means of "external use" is not particularly limited as long as it is a means other than "oral administration and injection," and can be suitably applied to the surface of the skin by means such as painting, sprinkling, or spraying.

[0098] The topical skin preparation (e.g., cosmetic) according to this embodiment can also be used as a topical skin preparation such as a quasi-drug or pharmaceutical. Examples of the form of the topical skin preparation include a topical liquid, a topical gel, a cream, an ointment, a liniment, a lotion, a cataplasm, a plaster, a spray, and an aerosol. The method of use can be the same as that of the cosmetic.

[0099] In the topical skin preparations (e.g., cosmetics) according to the present embodiment described above, the content of the ergothioneine compound in cosmetics such as lotions, facial cleansers, serums, emulsions, or creams is not particularly limited, and a preferred example is about 0.0001 to 10% by mass, but the blending amount can be appropriately set within a wide range up to less than 100% by mass depending on various conditions such as the dosage form used and the target of use. Among these, the content of the ergothioneine compound contained in products such as topical skin preparations is preferably 0.0001 to 1% by mass, and more preferably 0.001 to 0.1% by mass.

[0100] (Manufacturing Method) The manufacturing method of the topical skin preparation (e.g., cosmetic product) according to this embodiment is not particularly limited as long as it does not impair the effects of this embodiment, and for example, a commonly used method can be adopted.

[0101] Hereinafter, the present embodiment will be described using examples. Note that the present embodiment is not limited to the following examples, and the configuration can be appropriately changed within the scope of the gist of the present disclosure.

[0102] [Test Method] The effects of UVA irradiation on the epidermis and dermis of human skin were examined in the presence or absence of L-ergothioneine (EGT).

[0103] EGT concentrations used: 0.015% by mass, 0.063% by mass, 0.25% by mass, 1.0% by mass Skin fragment donor: Caucasian, female, age 45 years Skin fragment treatment: cultured in medium containing EGT for 2 days, medium changed once a day, UVA irradiation

[0104] (Experimental Example 1) An antibiotic-added DMEM medium containing 0.015% by mass of EGT was prepared, and skin pieces punched out were cultured in the medium at 37°C for 2 days (approximately 48 hours) (n=3). On the second day (approximately 24 hours after the start of culture), the medium was replaced with a fresh, identical medium. 24 hours and 48 hours after the start of culture, the irradiance was 16 J / cm ２ The skin pieces were irradiated with a dose of UVA of 32 J / cm ２The skin pieces were irradiated with UVA at a dose of 1000 kJ / min. The skin pieces were then removed from the culture medium and frozen at -80°C using liquid nitrogen. A 20-µm-thick frozen section containing the epidermis and dermis was prepared from the frozen skin pieces at -21°C using a cryostat (Leica CM3050S), and designated as test sample E1.

[0105] Experimental Example 2 Test sample E2 was prepared in the same manner as in Experimental Example 1, except that the EGT content in the medium was set to 0.063% by mass.

[0106] Experimental Example 3 Test sample E3 was prepared in the same manner as in Experimental Example 1, except that the EGT content in the medium was set to 0.25% by mass.

[0107] Experimental Example 4 Test sample E4 was prepared in the same manner as in Experimental Example 1, except that the EGT content in the medium was 1.0 mass %.

[0108] Reference Example 1 A test sample C1 was prepared in the same manner as in Experimental Example 1, except that the EGT content in the medium was set to 0% by mass (no EGT contained).

[0109] Reference Example 2 Test sample C2 was prepared in the same manner as in Experimental Example 1, except that the EGT content in the medium was set to 0% by mass (no EGT) and UVA irradiation was not performed.

[0110] [Evaluation Method] (Measurement of reactive oxygen species using a fluorescence microscope) Using a fluorescence microscope, the production level of reactive oxygen species (ROS) in the epidermis was measured.

[0111] The ROS generation level in the epidermis of the test sample was measured by using an H2-DCFDA fluorescent probe to generate fluorescence based on the ROS in the epidermis of the test sample, and detecting the fluorescence using an inverted microscope (manufactured by ZEISS) equipped with a confocal head LSM980 (manufactured by ZEISS). The results are shown in Table 1. There was no statistically significant difference between the ROS generation level in Experimental Example 1 and the ROS generation level in Reference Example 1. The ROS generation levels in Examples 2 to 4 were significantly lower than the ROS generation level in Reference Example 1.

[0112]

[0113] (Measurement of stratum corneum thickness) The test samples were observed with an inverted microscope (manufactured by ZEISS) to measure the thickness of the stratum corneum. The results are shown in Table 2.

[0114]

[0115] (Measurement of Mechanical Properties of Dermis by Atomic Force Microscopy) The mechanical properties of the dermis were measured using an atomic force microscope (AFM).

[0116] The mechanical properties of the dermis were measured by calculating the elastic modulus (MPa) from the force-indentation curves of the dermis. The quantification of the elastic modulus was performed by processing the approach curves obtained from each force-volume FV using BioMeca Analysis (registered trademark) processing software. The measurement principle is to calculate the elastic modulus by applying a theoretical physical model to the approach curve, and the Sneddon model was used for this calculation. The results are shown in Table 3.

[0117]

[0118] (Measurement of collagen fiber bundle thickness using atomic force microscope) Test samples were observed using an atomic force microscope (AFM), and four high-resolution topography images of collagen fiber bundles were obtained for each test sample. Representative topography images are shown in Figures 1A to 1F. In each topography image, 10 collagen fiber bundles were randomly selected, and the width of the collagen fiber bundles was measured. For each test sample, the average value of the width values ​​of the 40 collagen fiber bundles obtained was taken as the collagen fiber bundle thickness. The relative collagen fiber bundle thickness was calculated by dividing the collagen fiber bundle thickness values ​​of Examples 1 to 4 and Reference Examples 1 and 2 by the collagen fiber bundle thickness value of Reference Example 1. The results are shown in Table 4.

[0119]

[0120] [Discussion] Human skin fragments were cultured in a medium containing EGT to examine the effects of UVA irradiation on the skin. Specifically, the skin fragments cultured in a medium containing EGT were irradiated with UVA to examine the reactive oxygen species (ROS) generated, as well as the changes in the thickness of the stratum corneum and the elasticity of the skin due to UVA irradiation. Furthermore, changes in the dermis and the thickness of collagen fiber bundles were examined using an atomic force microscope.

[0121] As a result, as shown in Table 1, it was confirmed that EGT suppresses the generation of ROS in the epidermis due to UVA irradiation. Furthermore, as shown in Table 2, although UVA irradiation thins the stratum corneum (Reference Example 1), in Experiments 1, 2, and 4, in which EGT treatment was performed, the stratum corneum thickness was comparable to that of Reference Example 2, in which UVA irradiation was not performed. Note that accurate data could not be obtained in Experiment 3 due to an error, but those skilled in the art would fully understand that Experiment 3 also yields results similar to those of Experiments 1, 2, and 4. These results indicate that the reduction in stratum corneum thickness due to UVA irradiation was suppressed by EGT treatment. It is believed that the suppression of ROS generation in the epidermis due to UVA irradiation by EGT suppresses epidermal damage, such as a decrease in barrier function caused by ROS, and the resulting decrease in water evaporation, thereby suppressing the reduction in stratum corneum thickness.

[0122] Skin elasticity was evaluated using the dermis, which contains a large amount of collagen fibers. As a result, as shown in Table 3, although UVA irradiation reduced dermal elasticity (Reference Example 1), in Experimental Examples 1 to 4 in which EGT treatment was performed, the dermal elasticity modulus was comparable to that of Reference Example 2 in which UVA irradiation was not performed. Therefore, the results showed that EGT treatment improved or maintained elasticity.

[0123] Furthermore, the state of collagen fiber bundling in Experimental Examples 1 to 4, which were treated with EGT, and Reference Example 1, which was not treated with EGT, was observed using an atomic force microscope ( Figures 1A , 1C to 1F ). Interestingly, as shown in Figure 1A , in Reference Example 1, which was not treated with EGT, a planar image of collagen fiber bundles with a blurred appearance was observed due to UVA irradiation, whereas in the experimental group with EGT treatment (Experimental Examples 1 to 4, Figures 1C to 1F ), the collagen fibers were bundled together to form clearly formed collagen fiber bundles, resulting in a three-dimensional image of collagen fiber bundles. As shown in Table 4, while UVA irradiation reduces the thickness of collagen fiber bundles (Reference Example 1), in Experimental Examples 1 to 4, which were treated with EGT, the thickness of collagen fiber bundles was comparable to that of Reference Example 2, which was not treated with UVA irradiation. Therefore, it can be understood that EGT treatment significantly suppressed the decrease in collagen fiber bundle thickness due to UVA irradiation.

[0124] This specification includes the disclosure of Japanese Patent Application No. 2024-106682, from which the present application claims priority. All publications, patents, and patent applications cited in this specification are incorporated herein by reference in their entirety.

Claims

1. A composition for inhibiting the decrease in thickness of collagen fiber bundles caused by UVA irradiation, comprising an ergothioneine compound as an active ingredient.

2. The composition according to claim 1 for inhibiting the decrease in thickness of collagen fiber bundles in the dermis due to UVA irradiation.

3. The composition according to claim 1, which is an external skin preparation.

Images