Selective deodorant comprising propanediol caprylate

Abstract

A selective deodorant.

Description

[0001] Selective deodorant with propanediol caprylate

[0002] The invention relates to a deodorant that is selectively effective against Corynebacterium jeikeium (C. jeikeium).

[0003] Cosmetic products generally serve not only to make one look beautiful and attractive, but also contribute significantly to increased self-esteem and well-being. Accordingly, a wide variety of cosmetic products are used for daily cleansing and skin care.

[0004] One category of cosmetic products is deodorants and antiperspirants, which are applied under the arms to prevent unpleasant odors and perspiration. The cause of unpleasant odors is the decomposition of sweat, which is itself odorless, by bacteria. Among the byproducts of this decomposition are fatty acid residues, which characterize the typical, familiar smell of sweat. Although deodorants and antiperspirants are applied to the same area of ​​skin and pursue the same goal, they differ in their technical mechanisms of action.

[0005] Antiperspirants contain antiperspirant active ingredients that serve to inhibit and reduce perspiration. Antiperspirant active ingredients containing aluminum can clog the sweat glands.

[0006] Deodorants, on the other hand, are characterized by the fact that they do not impede the flow of perspiration. Instead, deodorants are understood to be products containing specific antimicrobial agents that reduce the growth of bacteria such as Corynebacterium jeikeium or Staphylococcus epidermidis. Consequently, the decomposition of odorless sweat is reduced, resulting in fewer unpleasant odors.

[0007] Conventionally, antiperspirants and deodorants are applied to the skin either using a roll-on applicator or as a spray. Sprays include both aerosol sprays powered by a propellant and pump sprays operated by a hand pump. Depending on the application method, the cosmetic preparations vary significantly in their composition.

[0008] A disadvantage of well-known deodorants is that the active ingredients used, as well as the formulation itself, have a general antimicrobial effect, thus reducing the overall population of bacteria on the skin. For example, the frequently used active ingredients ethylhexylglycerin, octenidine HCl, or ethanol also have a bactericidal effect against Corynebacterium jeikeium and Staphylococcus epidermidis, among others.

[0009] Staphylococcus epidermidis is a gram-positive bacterium of the genus Staphylococcus and is found on human skin and mucous membranes. In healthy individuals, S. epidermidis is not pathogenic. The presence of S. epidermidis on the skin protects it from colonization by pathogenic microorganisms. Furthermore, according to recent studies, S. epidermidis is not primarily involved in the development of body odor, so its inhibition represents an unnecessary intervention in the composition of the skin microbiome.

[0010] The Rossmann Isana Med 24H Ultra Sensitive Deo Roll-On (Mintel GNPD registration number 10798513) and DM Balea 24h Deodorant Roll-On (Mintel GNPD registration number 10577376) use the active ingredients

[0011] Furthermore, such deodorants are known from EP3236917A1.

[0012] Consequently, the use of these deodorants is often associated with damage to the skin biome. In particular, the population of Staphylococcus epidermidis is unnecessarily reduced.

[0013] One object of the present invention was therefore to provide skin microbiome-friendly deodorants effective against sweat odor, which, among other things, act selectively against Corynebacterium jeikeium and do not kill Staphylococcus epidermidis or only partially reduce its population on the skin.

[0014] Surprisingly, the requirements could be met by the invention. One aspect of the present invention is the use of propanediol caprylate for the selective reduction of the number of Corynebacterium jeikeium bacteria on human skin.

[0015] Another object of the invention is the use of propanediol caprylate in a cosmetic deodorant and / or antiperspirant for the selective reduction of the number of bacteria of the bacterium Corynebacterium jeikeium on human skin, wherein the deodorant and / or antiperspirant is applied to the skin.

[0016] The invention also relates to the use of a cosmetic deodorant and / or antiperspirant comprising propanediol caprylate for the selective reduction of the number of bacteria of the bacterium Corynebacterium jeikeium on human skin, wherein the deodorant and / or antiperspirant is applied to the skin.

[0017] In this context, the term "selective" means that there is a reduction / death of the population of the bacteria mentioned, while at the same time the number of skin-friendly bacteria, in particular the number of Staphylococcus epidermidis, is only limited or not reduced.

[0018] By definition, skin-friendly bacteria are Propionibacteria (except P. acnes), Proteobacteria, Corynebacteria and Staphylococcus aureus (except S. aureus and those that contribute to the formation of body odor).

[0019] In particular, the invention relates to the use of propanediol caprylate to reduce the number of bacteria of the bacterium Corynebacterium jeikeium on human skin, wherein the number of bacteria of the bacterium Staphylococcus epidermidis is only partially or not reduced.

[0020] A further advantageous aspect of the invention is the use of propanediol caprylate in a cosmetic deodorant and / or antiperspirant for the selective reduction of the number of Corynebacterium jeikeium bacteria on human skin, wherein the deodorant and / or antiperspirant is applied to the skin and wherein the number of Staphylococcus epidermidis bacteria is only partially or not at all reduced. The invention also relates to the use of a cosmetic deodorant and / or antiperspirant comprising propanediol caprylate for the selective reduction of Corynebacterium jeikeium bacteria on human skin, wherein the deodorant and / or antiperspirant is applied to the skin and wherein the number of Staphylococcus epidermidis bacteria is only partially or not at all reduced.

[0021] In the preceding paragraphs, the term "restricted" is used. For the purposes of this disclosure, this term is to be understood as meaning that the population of the bacteria mentioned is reduced by more than 1 log level when using the invention. The data refers to a measurement using the suspension test according to the invention.

[0022] Last but not least, an object of the invention is a cosmetic deodorant and / or antiperspirant preparation comprising propanediol caprylate.

[0023] The invention also relates to a non-therapeutic method for selectively reducing the number of bacteria of the bacterium Corynebacterium jeikeium on human skin by topical application of a deodorant and / or antiperspirant preparation comprising propanediol caprylate.

[0024] It is known that substances present on the skin, such as skin lipids and proteins, can inhibit the activity of potential deodorants, preventing them from having a deodorizing effect. Therefore, it is not clear whether, for example, antimicrobial substances automatically have a deodorizing effect. A challenge thus lies in identifying active ingredients that, in addition to being skin-friendly, primarily have a deodorizing effect and can be used as deodorants. Usable in this context means that skin irritation or other adverse effects are avoided.

[0025] It was surprisingly discovered that the use of propanediol caprylate in deodorant formulations and when applied under the armpits reduces the formation of typical body odor. Consequently, propanediol caprylate has a surprisingly effective deodorizing effect.

[0026] Consequently, another object of the invention is the use of propanediol caprylate as a deodorizing agent, particularly in cosmetic preparations that are applied topically to the skin. In particular, the application is to the underarm skin.

[0027] Unless otherwise stated, all weight percentages (wt%) specified below are based on the total weight of the preparation according to the invention, which in this case is a deodorant preparation and / or an antiperspirant preparation. Where ratios of certain components are disclosed in the following description, these ratios refer, unless otherwise stated, to weight ratios of the components.

[0028] Unless otherwise stated, all tests and measurements were carried out under "normal conditions". The term "normal conditions" refers to 20°C, 1013 hPa, and a relative humidity of 50%.

[0029] The advantage of the invention lies in its high antimicrobial selectivity. The compositions specifically lead to a significant reduction in the cell count of Corynebacterium jeikeium. At the same time, the compositions have no or only a minimal inhibitory effect on S. epidermidis, whose numbers on the skin are not significantly reduced. As explained in the examples described below, when applied under the armpit to human skin, the invention leads to a 90% reduction in the number of Corynebacterium jeikeium bacteria, while S. epidermidis showed no significant reduction in bacterial count.

[0030] It is preferred that the number of Corynebacterium jeikeium in a specific skin area decreases by at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, or at least 95% after application of the composition according to the invention, compared to the cell count in the relevant skin area before application of the composition. It is further preferred that the number of S. epidermidis in this skin area simultaneously decreases by at most 25%, at most 20%, at most 15%, at most 10%, at most 5%, or less, compared to the cell count in the relevant skin area before application of the composition.

[0031] Whenever the expression "after application" or an equivalent temporal reference is used in this disclosure, it always refers to a period of up to 48 hours after application. The term "skin" refers exclusively to human skin.

[0032] The preparations of the invention are advantageously characterized in that propanediol caprylate is contained in proportions of 0.01 to 10 wt.%, preferably 0.05 to 2 wt.% and particularly preferably 0.1 to 1 wt.%, in each case based on the total weight of the preparation.

[0033] The preparations of the present invention can be in various forms. Preferred preparation forms include, for example, a solution, a suspension, a water-in-oil (W / O) or oil-in-water (O / W) emulsion, or multiple emulsions, such as water-in-oil-in-water (W / O / W) or oil-in-water-in-oil (O / W / O) emulsions, a hydrodispersion or lipodispersion, or an aerosol. Furthermore, the preparations can also be in solid stick form, in which the stick material is transferred to the skin by abrasion.

[0034] In an advantageous embodiment, the preparations according to the invention are emulsions which, in addition to propanediol caprylate, contain further substances such as fats, oils, waxes and / or other fatty substances, as well as water and one or more emulsifiers, such as are commonly used for this type of formulation. Such emulsions can advantageously be formulated as a cream or lotion.

[0035] In a further advantageous embodiment, the preparations according to the invention are in the form of an alcoholic solution, preferably an ethanolic solution. In this embodiment, the preparations advantageously comprise an alcohol content, preferably an ethanol content, of 30% to 99% by weight, based on the total weight of the preparation. Due to their low viscosity, these preparations are particularly suitable for use in a pump atomizer that is operated without propellant gas.

[0036] Further embodiments include cosmetic products comprising a pressure vessel with a dispensing valve, a cosmetic preparation containing propanediol caprylate contained in the pressure vessel, and a propellant, in particular propane, butane, and / or nitrogen, also contained in the pressure vessel. The amount of propellant is selected such that, upon opening the dispensing valve, the cosmetic preparation is dispensed along with the propellant. In this way, the preparation becomes sprayable and can be applied to the skin. For such products, alcoholic, anhydrous preparations or emulsions are advantageously used as the preparation. The mixing ratio of the alcoholic solution, anhydrous preparation, or emulsion with propellant is preferably in the range of 20 to 40 wt.%, in particular 30 wt.%, or 60 to 80 wt.%, in particular 70 wt.%, of the preparation with propellant.Advantageously, the ratio is in the range of 10% preparation to 90% propellant, advantageously 15% preparation to 85% propellant, or 30% to 70%, and particularly 60% preparation to 40% propellant. According to the invention, these propellant-containing preparations then contain propanediol caprylate, advantageously in a proportion of 0.01 to 10% by weight, based on the total mass of the preparation without propellant.

[0037] Advantageous preparations of the invention are further characterized in that they contain an antiperspirant active ingredient. It is particularly advantageous if the antiperspirant active ingredient is selected from the group of aluminum salts with the formula [Al2(OH)2]2. m Cln], where m+n=6.

[0038] Examples of aluminium salts according to the invention are:

[0039] - Aluminum salts such as aluminum chloride AlCh, aluminum sulfate Ah(SO4)3

[0040] - Aluminum chlorides of the empirical molecular formula [Al2(OH) m Cl n ], where m+n=6

[0041] - Aluminum chlorohydrate [Al2(OH)sCI] x H2O (ACH)

[0042] Standard Al complexes: Locron P (Clariant), Locron L (Clariant), Micro-Dry (Reheis), ACH-331 (Summit), Aloxicoll PF 40 (Giulini)

[0043] - Activated Al complexes: Reach 501 (Reheis), AACH-324 (Summit), AACH-7171 (Summit), Aloxicoll P (Giulini), Aloxicoll SD100

[0044] - Aluminum sesquichlorohydrate [Ah OH sCh.s] x H2O

[0045] Standard Al complexes: Aluminum Sesquichlorohydrate (Reheis), AACH-308 (Summit)

[0046] - Activated Al complexes: Reach 301 (Reheis)

[0047] - Aluminum dichlorohydrate [Ah OH^Ch] x H2O

[0048] Furthermore, it is advantageous if at least one aluminum-zirconium salt is included as the antiperspirant active ingredient. Advantageously selected from the group are aluminum / zirconium trichlorohydrex glycine ([Al4Zr(OH)i3Ch] x H2O x Gly), aluminum / zirconium tetrachlorohydrex glycine ([Al4Zr(OH)i2Cl4] x H2O x Gly), aluminum / zirconium pentachlorohydrex glycine ([Al8Zr(OH)23Cls] x H2O x Gly), aluminum / zirconium octachlorohydrex glycine ([AlsZr(OH)2oCl8] x H2O x Gly), and the glycine-free aluminum / zirconium salts. Aluminum / zirconium tetrachlorohydrex glycine is particularly preferred. It is particularly advantageous if the aluminum-containing antiperspirant active ingredient is aluminum chlorohydrate, aluminum sesquichlorohydrate and / or aluminum / zirconium tetrachlorohydrex glycine, with aluminum chlorohydrate being the most preferred.

[0049] Advantageously, the total proportion of aluminum-containing antiperspirant active ingredients is from 1 wt.% to 30 wt.%, preferably from 2 wt.% to 25 wt.% and particularly preferably from 5 wt.% to 22 wt.%, based on the total weight of the preparation.

[0050] It is particularly advantageous if the proportion of aluminium chlorohydrate is from 1 wt.% to 30 wt.%, preferably from 2 wt.% to 25 wt.% and especially preferably from 5 wt.% to 22 wt.%, based on the total weight of the preparation.

[0051] Other advantageous embodiments of the invention are characterized in that they do not contain any aluminum-containing antiperspirant active ingredients as described and listed above.

[0052] Propanediol caprylate can be advantageously used in preparations with other antibacterial agents. Suitable antibacterial agents include ethylhexylglycerin, epsilon polylysine, and / or butyloctanoic acid.

[0053] It is also advantageous if the preparations do not contain any other antibacterial agents.

[0054] Furthermore, it is advantageous if the preparation also contains at least one or more perfume substances that are liquid under normal conditions. Advantageously selected perfume ingredients are chosen from essential oils, geraniol, geranyl acetate, linalool, linalyl acetate, tetrahydrolinalool, citronellol, citronellyl acetate, dihydromyrcenol, dihydromyrcenyl acetate, tetrahydromyrcenol, terpineol, terpinyl acetate, nopol, nopyl acetate, 2-phenyl benzyl alcohol, benzyl acetate, benzyl salicylate, benzyl benzoate, styrallyl acetate, amyl salicylate, dimethylbenzylcarbinol, trichloromethylphenylcarbinyl acetate, p-tert-butylcyclohexyl acetate, isononyl acetate, vetiveryl acetate, alpha-hexylcinamaldehyde, 2-methyl-3-(p-tert-butylphenyl)propanol, 2-methyl-3-(p-isopropylphenyl)propanal, 3-(p-tert--Butylphenyl) propanal, tricyclodecenyl acetate, tricyclodecenyl propionate, 4-(4-hydroxy-4-methylpentyl)-3-cyclohexenecarbaldehyde, 4-(4-methyl-3-pentenyl)-3-cyclohexenecarbaldehyde, 4-acetoxy-3-pentyltetrahydropyran, methyldihydrojasmonate, 2 -heptylcyclopentanone, 3-methyl -2-pentylcyclopentanone, n-decanal, 9-decenol-1, phenoxyethyl isobutyrate, phenylacetaldehyde dimethyl acetal, phenylacetaldehyde diethyl acetal, geranonitrile, citronellonitrile, cedryl acetate, 3-isocamphylcyclohephane, ethine, heliotropin, coumarin, eugenol, Vanillin, Diphenyloxide, Hydroxycitronellal, Ionone, Methylionone, Isomethylionone, Iron, cis-3-hexenol and esters thereof, indane musk fragrances, tetral in-musk fragrances, isochromane musk fragrances, macrocyclic ketones, macrolactone muscrown, macrolactone muscrown brassylate, and aromatic nitro-musk fragrances. Other perfume components that may be present but are not expressly preferred are listed in Arctander, Perfume and Flavor Chemicals (Chemicals) Vol.I and II (1969) and Arctander, Perfume and Flavour Materials of Natural Origin (1960).

[0055] Advantageously, the proportion of perfume substances that are liquid under normal conditions is 0.001 to 2 wt.%, preferably 0.005 to 1.5 wt.% and particularly preferably 0.01 to 1.4 wt.% based on the total weight of the preparation.

[0056] Andere Ausführungsformen enthalten ein oder mehrere der Parfuminhaltstoffe gewählt aus der Gruppe Alpha-Isomethyl Ionone, Anise Alcohol, Benzyl Alcohol, Benzyl Benzoate, Benzyl Cinnamate, Benzyl Salicylate, Butylphenyl Methylpropional, Cinnamal, Cinnamyl Alcohol, Citral, Citronellol, Coumarin, D-Limonene, Eugenol, Linalool, Amyl Cinnamal, Amylcinnamyl Alcohol, Evernia Furfuracea (Treemoss) Extract, Evernia Prunastri (Oakmoss) Extract, Farnesol, Geraniol, Hexyl Cinnamal, Hydroxycitronellal, Isoeugenol, Methyl 2-Octynoate, Acetyl Cedrene, Alpha-Pinene, Alpha-Santalol and Betasantalol, Alpha-Terpinene, Anethole, Benzaldehyde, Beta-Caryophyllene, Beta-Pinene, Camphor, Cedrus Atlantica Extract, Cinnamomum Zeylanicum Extract, Citrus Sinensis / Aurantium Dulcis Extract, Cymbopogon Citratus I Schoenanthus Extract, Damascenone, Damascene Delta, Damascone-Cis-Alpha, Damascone-Cis-Beta, Dimethyl Benzyl Carbinyl Acetate (Dmbca), Eucalyptus Extract, Eucalyptus Extract, Eugenia Caryophyllus Extract,Eugenyl Acetate, Laurus Nobilis Extract, Lavandula Hybrida Extract, Lavandula Officinalis Extract, Linalyl Acetate, Mentha Piperita Extract, Menthol, Methyl Salicylate, Narcissus Extract, Otne, Pelargonium Graveolens Extract, Peru Balsam Extracts and Distillates (Myroxylon Baisamum Var Pereirae), Pinus Mugo Extract, Pinus Pumila Extract, Propylidene Phthalide, Terpinolene, Trimethyl- Benzenepropanol, Turpentine, Verbena Absolute (Lippia Citriodora Kunth.), 3-Methyl-5- (2,2,3-Trimethyl-3-Cyclopentenyl)Pent-4-en-2-ol, Alpha-Terpineol, Amyl Salicylate, Carvone, Cinnamomum Cassia Extract, Citrus Aurantium Amara Extract, Citrus Bergamia Extract, Citrus Limonum Extract, Geranyl Acetate, Hexadecanolactone, Hexamethylindanopyran, Isoeugenyl Acetate, Jasmine Absolute (Grandiflorum), Juniperus Virginiana Extract, Pogostemon Cablin Extract, Rose Extract, Salicylaldehyde, Santalum Album Extract, Sclareol, Terpineol,Vanillin und Ylang Ylang Extracts. Andere vorteilhafte Ausführungsformen sind frei von Parfuminhaltstoffen gewählt aus der Gruppe Alpha-Isomethyl Ionone, Anise Alcohol, Benzyl Alcohol, Benzyl Benzoate, Benzyl Cinnamate, Benzyl Salicylate, Butylphenyl Methylpropional, Cinnamal, Cinnamyl Alcohol, Citral, Citronellol, Coumarin, D-Limonene, Eugenol, Linalool, Amyl Cinnamal, Amylcinnamyl Alcohol, Evernia Furfuracea (Treemoss) Extract, Evernia Prunastri (Oakmoss) Extract, Farnesol, Geraniol, Hexyl Cinnamal, Hydroxycitronellal, Isoeugenol, Methyl 2-Octynoate, Acetyl Cedrene, Alpha-Pinene, Alpha-Santalol and Betasantalol, Alpha-Terpinene, Anethole, Benzaldehyde, Beta-Caryophyllene, Beta-Pinene, Camphor, Cedrus Atlantica Extract, Cinnamomum Zeylanicum Extract, Citrus Sinensis / Aurantium Dulcis Extract, Cymbopogon Citratus I Schoenanthus Extract, Damascenone, Damascene Delta, Damascone-Cis-Alpha, Damascone-Cis-Beta, Dimethyl Benzyl Carbinyl Acetate (Dmbca), Eucalyptus Extract, Eucalyptus Extract,Eugenia Caryophyllus Extract, Eugenyl Acetate, Laurus Nobilis Extract, Lavandula Hybrida Extract, Lavandula Officinalis Extract, Linalyl Acetate, Mentha Piperita Extract, Menthol, Methyl Salicylate, Narcissus Extract, Otne, Pelargonium Graveolens Extract, Peru Balsam Extracts and Distillates (Myroxylon Baisamum Var Pereirae), Pinus Mugo Extract, Pinus Pumila Extract, Propylidene Phthalide, Terpinolene, Trimethyl- Benzenepropanol, Turpentine, Verbena Absolute (Lippia Citriodora Kunth.), 3-Methyl-5- (2,2,3-Trimethyl-3-Cyclopentenyl)Pent-4-en-2-ol, Alpha-Terpineol, Amyl Salicylate, Carvone, Cinnamomum Cassia Extract, Citrus Aurantium Amara Extract, Citrus Bergamia Extract, Citrus Limonum Extract, Geranyl Acetate, Hexadecanolactone, Hexamethylindanopyran, Isoeugenyl Acetate, Jasmine Absolute (Grandiflorum), Juniperus Virginiana Extract, Pogostemon Cablin Extract, Rose Extract, Salicylaldehyde, Santalum Album Extract, Sclareol, Terpineol, Vanillin und Ylang Ylang Extracts.,

[0057] The preparations can be applied to the skin once or several times as part of therapeutic or non-therapeutic, cosmetic treatment. In one embodiment, the preparations according to the invention are formulated for daily application to the skin.

[0058] Examples:

[0059] The following examples are intended to illustrate this invention, without limiting the invention to these examples. The numerical values ​​in the examples are percentages by weight, based on the total weight of the preparations.

[0060] Suspension tests were performed to demonstrate selective antimicrobial efficacy.

[0061] Test 1: Stock cultures in glycerol, prepared according to European standard EN 12353, are stored in a refrigerator at 5°C. The first passage is prepared from this liquid stock culture. Using a sterile, single-use inoculating loop, the culture is streaked onto appropriate agar plates (see culture conditions). This culture is then incubated (see culture conditions). A second passage is then prepared from this first passage by collecting a few colonies with a sterile inoculating loop and streaking them onto another, new agar plate. This second passage is then incubated for 24 hours at the appropriate temperature (see culture conditions). The resulting second passage can be used for the suspension test.

[0062] Using a sterile inoculation loop, a few colonies from the second passage are collected and added to 10 mL of medium (see culture conditions) in a baffle flask containing 5 g of glass beads (0.4 mm) and vortexed (shaken) for 3 minutes. The approximate cell count per mL is then adjusted using optical density (OD). The optical density is determined using an Eppendorf photometer at 600 nm. To eliminate the influence of the medium, a blank is prepared using the medium to be used. The culture is then measured using the "Sample" function. The resulting OD must be adjusted to a value of approximately 0.08 (±0.01) and then diluted 1:100 with medium. This dilution strategy yields an approximate cell count of 1 x 10⁻⁶. 5 .

[0063] 500 pL of formulation or raw material solution are placed in sterilized Eppendorf tubes. For the positive control, 500 pL of medium (see culture conditions) are added. Each test always involves duplicate determination of the individual components. After adding 500 pL of the prepared culture suspension, the actual test begins. From this point on, 1 / 3 dilutions of all samples are prepared with neutralization medium after 20 min, 60 min, and 180 min (900 pL neutralization medium + 100 pL test sample). Don't forget to vortex! The diluted samples are plated onto agar plates (see culture conditions) using a spiral plater. After the test is complete, all agar plates are placed in the incubator for incubation and evaluated on the Countermat after incubation (see culture conditions).

[0064] The incubated plates are counted using a Countermat. A pre-existing template (SUS template) is used for the respective analyses in Excel. This template automatically generates the chart from the Countermat data and calculates the reduction factors. After duplicate testing, a report is generated that documents the test description, the chart, and the reduction factors.

[0065] Cultural conditions

[0066] BHI medium

[0067] 37 g brain and heart broth per 1000 mL dehydrated water

[0068] AC Medium

[0069] 37 g brain and heart broth

[0070] 5g D(+)-Glucose

[0071] 1mL Tween 80 to 1000 mL VE-H2O

[0072] Neutralizing medium

[0073] 6g Tween 80

[0074] 6g saponin

[0075] 0.2g L-Histidine

[0076] 0.6g lecithin

[0077] 1g sodium thiosulfate

[0078] 0.2g peptone from casein, tryptically digested

[0079] 1.7g sodium chloride in 200 mL deionized water

[0080] Raw material formulation

[0081] 0.5% propanediol caprylate in water

[0082] Consequently, it has been shown that the use of propanediol caprylate leads to a selective reduction of Corynebacterium jeikeium.

[0083] Further example recipes:

[0084] Roll-ons

[0085] Aerosols

[0086] The filling ratio (bulk:propellant) can be selected, among others, between 10:90, 15:85, 30:70, or 50:50 (based on volume). Nitrogen, compressed air, and a propane-butane mixture (2:7) were used as propellant.

[0087] Pump spray / atomizer

[0088] Pins

Claims

Claims 1. Use of propanediol caprylate for the selective reduction of the number of bacteria of the bacterium Corynebacterium jeikeium on human skin.

2. Use of propanediol caprylate in a cosmetic deodorant and / or antiperspirant preparation for the selective reduction of the number of bacteria of the bacterium Corynebacterium jeikeium on human skin, wherein the deodorant and / or antiperspirant is applied to the skin.

3. Use of a cosmetic deodorant and / or antiperspirant preparation comprising propanediol caprylate for the selective reduction of the number of bacteria of the bacterium Corynebacterium jeikeium on human skin, wherein the deodorant and / or antiperspirant is applied to the skin.

4. Use according to one of claims 2 or 3 characterized in that propanediol caprylate is contained in proportions of 0.01 to 10 wt.%, preferably 0.05 to 2 wt.% and particularly preferably 0.1 to 1 wt.%, in each case based on the total weight of the preparation.

5. Use according to one of claims 2 to 4, characterized in that the preparation comprises ethanol.

6. Use according to claim 5 characterized in that the preparation comprises ethanol in a proportion of 30 wt.% to 99 wt.%, based on the total weight of the preparation.

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