Combination product for relieving the symptoms associated with upper respiratory tract infections

Abstract

The present invention relates to a combination product comprising, as active substances, at least erysimum, propolis, zinc, ribwort plantain, and marshmallow. The invention also relates to the use of a combination product as defined above for treating the symptoms associated with upper respiratory tract infections. Finally, the invention relates to the use of a combination product as defined above for treating the symptoms associated with throat infections and irritation.

Description

Combination product to relieve symptoms associated with upper respiratory tract infections

[0001] The present invention relates to a combination product comprising, as active substances, at least erysimum, propolis, zinc, ribwort plantain, and marshmallow. The invention also relates to the use of a combination product as defined above for the treatment of symptoms associated with upper respiratory tract infections. Finally, the invention relates to the use of a combination product as defined above for the treatment of symptoms associated with throat infections and irritations.

[0002] BACKGROUND

[0003] Upper respiratory tract infections are a medical term for a specific infection in the nose, throat, or sinuses. These types of infections are generally characterized by the symptoms of the common cold and are most often caused by viruses. However, in some cases, bacteria are also responsible for triggering these infections.

[0004] Although these types of infections can occur in anyone, they are more common in children, who generally tend to have weaker immune systems. While children are more susceptible to upper respiratory tract infections, adults are more frequently affected by lower respiratory tract infections, which affect the lungs, throat, and airways and can cause serious complications.

[0005] Among the infections of the upper respiratory tract, we can mention the following pathologies: rhinitis, rhinopharyngitis, laryngitis or sinusitis.

[0006] Rhinitis is the medical term describing irritation and inflammation (acute or chronic) of the mucous membranes of the nasal cavity. Rhinitis can be allergic or non-allergic. When chronic, it significantly impacts the quality of life of those affected, to the point that the WHO published a new classification of the disease in 2001.

[0007] Rhinitis is often accompanied by other conditions such as asthma and / or sinusitis, and it is a cause of insomnia and fatigue. Fifty percent (50%) of patients with rhinitis have nonspecific bronchial hyperreactivity, and therefore an increased risk of asthma. Conversely, almost all asthmatics have rhinitis (more or less acute) associated with asthma attacks.

[0008] The symptoms are:

[0009] -runny nose (rhinorrhea);

[0010] -nasal congestion which can lead to nasal obstruction;

[0011] -irritation of the mucous membranes of the nose, with or without redness, itching and lesions (scabs, ulcerations...) and possibly accompanied by irritation of the eyes, throat and / or ears.

[0012] Acute non-allergic rhinitis can be induced:

[0013] -by an infection (bacterial or, more often, viral). In the latter case, acute viral rhinitis can lead to a loss of smell (35% of dysosmia cases) when an overabundance of mucus covers the olfactory epithelium to the point of preventing the brain from recognizing odors.

[0014] -by structural defects of the nasal passages: displaced walls, obstructive nasosinus polyposis (nasal passage more or less obstructed by polyps).

[0015] -by pathological hormonal changes or those related to pregnancy ("pregnancy rhinitis" or "rhinitis of pregnancy" occurring in approximately 30% of pregnant women, with a sensation of "blocked nose"). This generally occurs after the first trimester and worsens during the third trimester, most often disappearing two weeks after delivery.

[0016] -due to abuse of certain medications (nasal decongestant, aspirin, certain antihypertensives, erectile dysfunction medications), it will be called in this case privinism or rhinitis medicamentosa.

[0017] Rhinopharyngitis

[0018] Rhinopharyngitis is a very common infection of the respiratory tract, specifically the nasopharynx, the cavity extending from the nasal passages to the pharynx. Symptoms of rhinopharyngitis usually last between 7 and 10 days. Very common in young children from the age of 6 months, it occurs mainly in the autumn and winter. A child can experience between 7 and 10 episodes of rhinopharyngitis per year.

[0019] Laryngitis

[0020] Laryngitis is an inflammation of the larynx, often caused by an infection of viral or bacterial origin. The severity of laryngitis varies depending on the location of the infection. There are also chronic irritative laryngitis cases caused by smoking or vocal abuse.

[0021] The diagnosis of laryngitis is clinical and involves a combination of dysphonia (hoarseness, progressive loss of voice) and dyspnea (particularly in children due to the narrowness of the laryngeal airway, inspiratory bradypnea with retractions, or stridor). In cases of subglottic obstruction, dyspnea is the predominant symptom. In cases of glottic obstruction, dysphonia is the predominant symptom.

[0022] There are different types of laryngitis: chronic laryngitis, acute subglottic laryngitis in children, stridulous laryngitis, and pseudomyxomatous laryngitis.

[0023] Sinusitis

[0024] Sinusitis is an inflammation or infection of one or more of the four sinuses (maxillary, frontal, sphenoid or ethmoid) in the human body.

[0025] When a virus, fungus (mycosis), bacteria, or allergy affects the nasal mucous membranes, they react by becoming inflamed and swollen, causing sinus obstruction. As a result, mucus is no longer drained normally, and viruses or bacteria can multiply rapidly. Sinusitis therefore begins, in most cases, as a viral rhinopharyngitis, which impairs the cleansing capacity of the nasal and sinus cilia, and can progress to a true bacterial sinusitis. The sensation of pressure that the patient may experience is due to the increased pressure caused by the sinus obstruction.

[0026] The main viruses involved are: Rhinovirus, Myxovirus and Adenovirus.

[0027] The main bacteria responsible for sinus superinfections are: Haemophilus influenzae, Streptococcus pneumoniae, Moraxella catarrhalis, Staphylococcus aureus.

[0028] -Mushrooms: Aspergillus

[0029] Sinusitis can be of two types:

[0030] -Acute: caused in most cases by a viral infection such as a cold, it is treated in 7 to 12 days. It can also be caused by allergies or dental abscesses.

[0031] -Chronic: These can be the result of poorly treated infectious episodes and are often exacerbated by anatomical or allergic factors. Sinusitis is considered chronic when it lasts longer than 2 weeks and up to 4-8 weeks. However, acute sinusitis can be considered chronic if it recurs 2 to 4 times within the same year.

[0032] Consumers are increasingly opting for natural solutions and are reluctant to use active ingredients.

[0033] Among the existing natural solutions, one example is the Pediakid Nose-Throat product which contains 40% agave syrup and prebiotic fibers from Acacia Fibregum. TM 15%, a hydroglycerin extract of plants and 8% propolis (Thyme, Primrose, Mallow, Elderberry, Linden, Acerola, Ginger, Propolis), Vitamin C, Copper and Zinc.

[0034] We can also mention the Actirub® children's product marketed by the company Laboratoire Santé Verte which contains dry extract of Marshmallow root (Althaea officinalis), dehydrated concentrated juice of Black Elderberry (Sambucus nigra), N-acetyl-L-cysteine, dry extract of Greater Plantain leaves (Plantago major), dry extract of Blackcurrant leaf buds (Ribes nigrum), dry extract of Poppy flowers (Papaver rhoeas), dry extract of Propolis standardized to 6% polyphenols, vitamin C 149%, dry extract of Grapefruit seeds (Citrus paradisi) standardized to 45% bioflavonoids and vitamin D3.

[0035] Furthermore, a sore throat is a common reason for seeking medical advice. It is a symptom rather than a disease in itself. It can be diffuse or localized to the tonsils, pharynx, or larynx.

[0036] Locations of sore throat

[0037] - Pharyngitis: This is an inflammation of the tissues of the throat (pharynx). Swallowing, speaking or even breathing can become painful.

[0038] - In tonsillar involvement (tonsillitis), the pain is more localized and located in one or both tonsils, causing significant difficulty swallowing. The pain may also radiate into the ear.

[0039] Epiglottitis is an inflammation of the epiglottis (the small cartilaginous flap that closes the larynx during swallowing). It is rare but potentially serious because it can cause breathing difficulties.

[0040] A sore throat is characterized by tingling, pain or burning sensations, and is sometimes associated with difficulty swallowing or speaking, as well as other symptoms depending on the location and cause of the illness.

[0041] In 80% to 90% of cases, a sore throat is caused by a virus. In 10% to 15% of cases, tonsillitis is due to a bacterial infection.

[0042] Sore throat of viral origin:

[0043] It could be pharyngitis or the beginning of viral rhinopharyngitis which is then accompanied by coughing, sneezing and nasal obstruction as in the flu for example.

[0044] Viral sore throats are usually accompanied by a moderate fever (between 38 and 39°C). They can be caused by many common viruses, but also by mononucleosis, herpes, measles, chickenpox, etc.

[0045] Sore throat of bacterial origin:

[0046] Several types of bacteria can infect the throat.

[0047] Strep throat is caused by group A streptococcus (less commonly group B or C). It is accompanied by fever, swelling of one tonsil, which may be red or speckled with white spots; in the neck, a swollen and painful lymph node is often found on the same side as the affected tonsil. This type of tonsillitis can be serious when the streptococcus is group A because it can affect the entire body, particularly the kidneys and heart. It must therefore be treated promptly with antibiotics.

[0048] Tonsillitis:

[0049] Chronic tonsillitis refers to inflammation of the tonsils, usually occurring after repeated bouts of tonsillitis. It causes mild pain or difficulty swallowing, but this can worsen during flare-ups of a fever. The tonsillar crypts may fill with hard, whitish secretions called caseum, which have a foul odor.

[0050] Epiglottitis:

[0051] Epiglottitis is usually caused by the bacterium that causes pneumonia and meningitis, Haemophilus influenzae type B (Hib). This disease has become rare since the widespread vaccination against Haemophilus influenzae in children.

[0052] Sore throats can also be caused by:

[0053] - An allergic reaction to animal hair, mold or pollen.

[0054] - Dry air, especially in winter when houses are heated or in summer because of air conditioning.

[0055] - Pollution or chemical irritants such as tobacco smoke or the evaporation of products such as glues, paints, household products….

[0056] - Pharyngolaryngeal inflammation following vocal overuse.

[0057] - Gastroesophageal reflux causing pharyngitis due to the backflow of acidic stomach fluid into the throat.

[0058] A sore throat that persists for more than a week may be a sign of a more serious problem:

[0059] - An HIV infection, a gonorrhea infection.

[0060] - The presence of a tumor of the pharynx or larynx.

[0061] Possible complications:

[0062] Most sore throats, while uncomfortable, clear up on their own within 5 to 7 days. A sore throat caused by bacteria can lead to complications.

[0063] To relieve sore throats, there are various products on the market.

[0064] Consumers are increasingly opting for natural solutions.

[0065] Among the existing natural solutions, one example is Granions Kid Bio Nose & Throat, which contains agave syrup, hydroglycerin fluid extract of propolis*, thyme aerial parts extract (Thymus vulgaris)*, acerola fruit extract (Malpighia glabra, including vitamin C)*, mallow aerial parts extract (Malva sylvestris)*, concentrated lemon juice (Citrus limon)*, and chamomile flower extract (Matricaria chamomilla)* (*Ingredients from organic farming). Another example is Petit Chêne Respiratory Comfort, which combines agave syrup, plant extracts (primrose and eucalyptus), propolis, and mullein.

[0066] None of the products offered contain the association that is the subject of the present invention.

[0067] The Applicant has developed, and this is the subject of the present invention, a combination product comprising, as active substances, at least erysimum, propolis, zinc, ribwort plantain, and marshmallow. The invention relates to a combination product comprising, as active substances, at least erysimum, propolis, zinc, ribwort plantain, and marshmallow for the relief of symptoms associated with upper respiratory tract infections.

[0068] The invention also relates to the use of a combination product as previously defined for the treatment of symptoms associated with upper respiratory tract infections. Finally, the invention relates to the use of a combination product as previously defined for the treatment of symptoms associated with throat infections and irritations.

[0069] For the purposes of this invention, "relieving symptoms associated with upper respiratory tract infections" means a product that soothes the throat, clears the upper respiratory tract, particularly the nose, and also contributes to the proper functioning of the immune system.

[0070] Such a product therefore makes it possible to relieve symptoms related to upper respiratory tract infections with products of natural origin and to treat a larger number of people.

[0071] The product according to the present invention also has the advantage of preferably containing no artificial colorings or allergens and of preferably being lactose-free or gluten-free.

[0072] The product of the present invention has a galenic form suitable for adults but also for children, preferably in liquid form, more preferably in the form of an oral solution.

[0073] The product according to the present invention, although containing products of natural origin, has a pleasant taste and smell.

[0074] The present invention relates to a combination product, comprising as active substances, at least erysimum, propolis, zinc, ribwort plantain and marshmallow to help relieve symptoms associated with upper respiratory tract infections.

[0075] The present invention also relates to a combination product, comprising as active substances, at least erysimum, propolis, zinc, ribwort plantain and marshmallow for its use in the treatment of symptoms related to upper respiratory tract infections.

[0076] In certain embodiments, the combination product according to the invention comprises, in addition to erysimum, propolis, zinc, ribwort plantain and marshmallow, as active substances:

[0077] -Plants or plant extracts, such as, for example, the poppy

[0078] -Vitamins and minerals, such as vitamin C, for example

[0079] -Honey

[0080] In certain embodiments, the combination product of the invention is characterized in that erysimum, propolis, zinc, ribwort plantain and marshmallow are present in a quantity:

[0081] -0.5 to 10% preferably 1 to 8% erysimum

[0082] -0.01 to 10%, preferably 0.05 to 8% propolis

[0083] -0.001 to 1%, preferably 0.01 to 0.5% zinc

[0084] -0.001 to 3%, preferably 0.05 to 2% of ribwort plantain

[0085] -0.01 to 3%, preferably 0.05 to 2% marshmallow

[0086] as a percentage by weight relative to the total weight of the composition, in a physiologically acceptable medium, the percentage by weight of erysimum, ribwort plantain and marshmallow being expressed in plant equivalent.

[0087] Preferably, the physiologically acceptable medium is a liquid medium. Preferably, the combination product is in the form of an oral solution.

[0088] Erysimum, ribwort plantain and marshmallow may be present as ingredients in a combination product of the invention in a more or less purified form, in particular in the form of a plant extract.

[0089] The various embodiments of the invention are particularly described in the detailed description below. These embodiments can be considered separately or in combination with each other.

[0090] In the present invention, the applicant has demonstrated that the combination of erysimum, propolis, zinc, ribwort plantain and marshmallow has a synergistic effect to help relieve symptoms associated with upper respiratory tract and throat infections.

[0091] By synergistic effect, it is understood according to the present invention that the combination of erysimum, propolis, zinc, ribwort plantain, and marshmallow has an effect on the relief of symptoms related to upper respiratory tract infections, during treatment, that is greater than the cumulative effects of a treatment (a) comprising the administration of erysimum, not combined with propolis, zinc, ribwort plantain, and marshmallow, and conversely of a treatment (b) comprising the administration of propolis, not combined with erysimum, zinc, ribwort plantain, and marshmallow, or of a treatment (c) comprising the administration of zinc not combined with erysimum, propolis, ribwort plantain, and marshmallow, or of a treatment (d) comprising the administration of ribwort plantain not combined with erysimum, propolis, zinc, and marshmallow, or of a treatment (e) comprising Marshmallow, not associated with erysimum or propolis,with zinc and lanceolate plantain.,

[0092] Erysimum

[0093] Sisymbrium officinale, also known as wallflower (Erysimum), is a genus of dicotyledonous plants in the Brassicaceae family. This genus includes wallflowers, which comprise both cultivated ornamental species and various wild forms. Wallflower has pain-relieving effects and active ingredients similar to those of promethazine. Possessing expectorant properties, wallflower leaves can soothe coughs and laryngitis. They are therefore recommended for hoarseness. Because these same leaves are mucolytic, they can also facilitate the expulsion of mucus. They also help prevent scurvy and stimulate the entire body. The flowering tops of this plant have the same properties as the leaves.

[0094] In the context of the present invention, the flowering tops are preferably used.

[0095] According to a preferred embodiment of the present invention, the composition comprises 0.5 to 10%, preferably 1 to 8%, of dry extracts of erysimum as a percentage by weight relative to the total weight of the composition, the percentage being expressed as plant equivalent.

[0096] In the context of the present invention, the extraction ratio of erysimum is 4:1.

[0097] Propolis

[0098] Propolis refers both to a resinous substance produced by certain plants and to a complex material made by bees from this plant resin and wax.

[0099] Plant propolis refers to a series of resinous, gummy and balsamic substances found on plants. The main tree species producing propolis are conifers (bark of pines, firs, spruces) and the buds of several species of alder, willow, birch, plum, ash, oak and elm, poplar (which seems to be the most important source) and horse chestnut.

[0100] Bee propolis is a complex made by the bee from its secretions and the plant propolis it has collected.

[0101] The propolis collected from the hive is generally composed of:

[0102] - Resins and balms: 50 to 55%

[0103] - wax: 30 to 40%

[0104] - volatile or essential oils: 5 to 10%

[0105] - pollen: 5%

[0106] - Miscellaneous materials: 5%

[0107] This propolis also contains many other elements such as organic acids, numerous flavonoids, trace elements, and many vitamins. It also contains parabens, whose antibacterial and antifungal properties help fight pathogens in the hive.

[0108] In the beehive, propolis has multiple uses. It acts as a mortar to seal cracks and gaps, to waterproof against moisture and mold growth, to reinforce honeycombs or damaged parts of the hive, and to protect the colony by reducing the hive entrance. It also serves as an antiseptic varnish, deposited in a thin layer inside the cells before the queen lays her eggs, or to smooth the interior walls of the hive. Furthermore, it is used to mummify dead intruding animals (such as rats and mice) that are too large for the bees to remove, thus preventing their decomposition.

[0109] Raw propolis or propolis in tincture form is an anti-infective agent (antifungal, antiseptic, antibiotic). It also has anesthetic, healing, and anti-inflammatory properties and increases cellular metabolism.

[0110] For internal use, it would be used in the form of a mother tincture or in the form of a dry extract in otolaryngology against loss of voice, hoarseness, tonsillitis, sore throats, coughs, colds, bronchitis, pharyngitis, otitis and sinusitis.

[0111] In the context of the present invention, propolis is a complex material produced by bees from plant propolis and wax

[0112] According to a preferred embodiment of the present invention, the composition comprises from 0.01 to 10% preferably 0.05 to 8% of propolis as a percentage by weight relative to the total weight of the composition.

[0113] Zinc

[0114] Zinc is a trace element essential in small doses for animal and human life.

[0115] In very small quantities, zinc in its absorbable form is an important trace element, essential for plant and animal organisms. When properly absorbed by the body, it activates enzymes, influences growth, and promotes biochemical reactions and controls at the level of the lung surfaces. The human body contains 2 to 4 grams of zinc. Daily requirements can be estimated at between 10 and 14 mg / day for a man or a breastfeeding woman.

[0116] Zinc is found in various yeasts (up to 100 mg per kilogram) and in beef (from 50 mg to 120 mg per kilogram), but also in a multitude of commercially available foods.

[0117] Even a slight deficiency has an impact on certain functions, including the immune system responsible for defending against certain infections.

[0118] According to a preferred embodiment of the present invention, the composition comprises from 0.001 to 1%, preferably 0.01 to 0.5% of zinc as a percentage by weight relative to the total weight of the composition.

[0119] The plantain

[0120] Plantago lanceolata, the Ribwort Plantain, is a perennial herbaceous plant of the Plantaginaceae family.

[0121] It is a medium-sized plant (15-50 cm), which takes on variable forms depending on the richness of the environment, the amount of sunlight and the hydromorphism of the soil.

[0122] The leaves of the ribwort plantain are lance-shaped (lanceolate) and arranged in a basal rosette; the 3-5 prominent, almost parallel veins are marked.

[0123] Plantain is used primarily against all diseases of the respiratory organs and particularly in cases of lung congestion, chesty cough, whooping cough, or pulmonary asthma, to disinfect the respiratory tract.

[0124] The entire plant is edible (leaves, flowers, fruits, seeds). In the context of the present invention, plantain leaves are preferably used.

[0125] According to a preferred embodiment of the present invention, the composition comprises from 0.001 to 3%, preferably 0.05 to 2% of ribwort plantain as a percentage by weight relative to the total weight of the composition, the percentage being expressed as plant equivalent.

[0126] In the context of the present invention, the extraction ratio of ribwort plantain is 10:1.

[0127] Marshmallow

[0128] Marshmallow (Althaea officinalis L.), also called wild marshmallow or white mallow, is a perennial herbaceous plant of the Malvaceae family, common in Europe. It is cultivated as a medicinal plant for its emollient properties, as an ornamental plant for its flowers, and sometimes as a vegetable, mainly for its roots.

[0129] This plant, rich in mucilage, has soothing, emollient, cough-reducing, laxative and appetite-stimulating properties.

[0130] In the context of the present invention, marshmallow roots are preferably used.

[0131] According to a preferred embodiment of the present invention, the composition comprises from 0.001 to 3%, preferably 0.05 to 2% of marshmallow as a percentage by weight relative to the total weight of the composition, the percentage being expressed as plant equivalent.

[0132] In the context of the present invention, the marshmallow extraction ratio is 4:1.

[0133] Physiologically acceptable environment

[0134] A physiologically acceptable medium is one that has no toxic or harmful effects under the conditions of use and is inert with respect to the active ingredients of the combination product. Such a medium may, for example, include various adjuvants depending on its therapeutic or cosmetic purpose, such as, but not limited to, flavorings, colorants, fillers, preservatives, diluents, wetting or suspending agents, etc. Such media may also allow for the immediate, modified, or delayed release of one or more of the active ingredients.

[0135] The physiologically acceptable medium may consist of water, fruit puree and / or juice, texturizers, emulsifiers, colors, preservatives, flavors, sugar or sugars.

[0136] By "fruit puree and / or juice" we mean a preparation more or less liquid, in particular depending on the nature of the fruit and / or the fineness of the grinding, prepared by grinding, pressing or other extraction process of one or more fruits and possibly concentration of the resulting pulp and / or separation (in particular filtration) of the seeds, achenes and / or all or part of the pulp, and / or flash pasteurization.

[0137] The fruits can be chosen from: apple, banana, strawberry, peach, raspberry, blackberry, mango, kiwi, blueberry, blackcurrant, redcurrant, orange, cherry, fig, pear, apricot, coconut, passion fruit, guava, papaya, melon, lychee, pineapple, lemon, mandarin, mirabelle plum, grapefruit, grape, rhubarb, and mixtures thereof, without this list being exhaustive. Preferably, the composition according to the invention includes strawberry juice.

[0138] Texturizers are compounds that modify the texture of the products in which they are incorporated. Examples of texturizers include: guar and locust bean gums; gum arabic, xanthan gum, and gellan gum; carrageenan; starches (native or modified); microcrystalline cellulose; gelatin; pectin; alginates (E400 to E405); agar-agar; and mixtures thereof. The term "emulsifiers" refers to amphiphilic compounds characterized by their HLB (Hydrophile Lipophilic Balance) value, particularly those capable of stabilizing oil-in-water emulsions (especially useful when adding, for example, fat-soluble active ingredients such as fat-soluble vitamins). Examples of food emulsifiers include lecithin and its derivatives, found notably in egg yolks; mono- and diglycerides of fatty acids; and polysorbate 80. Preferably, the composition according to the invention comprises xanthan gum.

[0139] The term "colorants" refers to compounds of natural or synthetic origin capable of imparting color to a product. Examples of food colorings are known in Europe under the codes E100 to E180.

[0140] The term "preservatives" refers to compounds that inhibit the growth of microorganisms, particularly yeasts and / or molds and / or bacteria, especially Staphylococcus aureus, in the composition. Examples of food preservatives include sorbic acid and its salts (E200 to E203); benzoic acid and its salts (E210 to E219); sulfites and their derivatives (E220 to E228); natamycin; nisin; and mixtures thereof. Preferably, the composition according to the invention does not include any preservatives. Preferably, the composition according to the invention includes potassium sorbate.

[0141] The term "flavorings" refers to compounds of natural or synthetic origin capable of altering the taste of the composition on their own. Examples of flavorings include apricot, pineapple, banana, blackcurrant, cherry, lemon, lime, strawberry, raspberry, passion fruit, mandarin, mint, orange, pistachio, pear, licorice, rose, anise, blueberry, cinnamon, ginger, grapefruit, apple, kiwi, lychee, melon, coconut, peach, redcurrant, guava, grenadine, mango, blackberry, papaya, tea, vanillin, natural vanilla extract, essential oils, and mixtures thereof. Preferably, the composition according to the invention comprises a strawberry flavoring.

[0142] For the purposes of this invention, "sugar" or "sugars" means any sweetening carbohydrate, preferably glucose syrup, sucrose, glucose, fructose, invert sugar, honey, agave syrup, maltose, polyol, or mixtures thereof. Preferably, the sugar used in this invention is agave syrup.

[0143] Additional asset(s)

[0144] Any additional active ingredient with nutritional value and / or that helps relieve symptoms associated with upper respiratory tract infections may also be added to the combination products of the invention. The combination product may include, for example, vitamins, minerals, essential amino acids, essential fatty acids, trace elements, various plant extracts, fibers, antioxidants, and flavonoids.

[0145] Advantageously, such an additional active ingredient can be intended to enhance the desired effect as described above.

[0146] Of course, a person skilled in the art will take care to choose the additional assets and their quantity in such a way that the advantageous properties of the composition according to the invention are not, or substantially not, altered by the envisaged addition.

[0147] Examples of additional usable assets include:

[0148] - Water-soluble and fat-soluble vitamins. Examples of water-soluble vitamins present in the syrupy product prepared according to the invention include: vitamin B1 (thiamine), vitamin B2 (riboflavin), vitamin B3 (nicotinic acid), also known as vitamin PP (Pellagra Preventive), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B8 or H (biotin), vitamin B9 (folic acid), and vitamin B12 (cobalamin). Examples of fat-soluble vitamins present in the syrupy product prepared according to the invention include: vitamin A (retinol), vitamin D3 (cholecalciferol), vitamin E (a mixture of tocopherols and tocotrienols), and vitamin K (phylloquinone).

[0149] - Antioxidants, such as curcuminoids; carotenoids, particularly those selected from beta-carotene, astaxanthin, zeaxanthin, lutein, or compounds containing them such as goji berries; polyphenol compounds, flavonoids such as catechins; proanthocyanidins, anthocyanins, OPCs (oligomeric procyanidins); ubiquinones; coffee extracts containing polyphenols and / or diterpenes; chicory extracts; ginkgo biloba extracts; grape extracts rich in proanthocyanidins; chili pepper extracts; soy extracts; cocoa; pomegranate; Emblica; Coenzyme Q10; selenium,

[0150] - minerals, such as magnesium, calcium, copper, iron, iodine, manganese, selenium, chromium (III),

[0151] - amino acids, particularly sulfur-containing amino acids, such as glutathione precursors, selenium amino acids, and citrulline,

[0152] -phytosterols, resveratrol, hesperidin, neohesperidin, orthosilicic acid, monomethylsilanetriol, and mixtures thereof.

[0153] Preferably, a combination product according to the invention is administered orally. Suitable oral dosage forms include, for example, tablets, capsules, lozenges, powders, granules, lyophilized powders, oral solutions, and syrups. Tablets, powders, granules, lyophilized powders, oral solutions, and syrups constitute the currently preferred pharmaceutical form suitable for oral administration. In the case of preparing a solid composition in the form of an oral solution, the active ingredients, such as hedge mustard, propolis, zinc, ribwort plantain, and marshmallow, may be mixed with a physiologically acceptable vehicle such as fruit juice, a thickener / texturizer, a flavoring, and a preservative.

[0154] A liquid preparation is obtained by mixing the active ingredients erysimum, propolis, zinc, ribwort plantain and marshmallow with concentrated strawberry juice, strawberry flavouring, xanthan gum and potassium sorbate.

[0155] Example 1: Composition according to the invention (Table 1): Designation Unit quantity in mg per 10 ml Percentage (in % relative to the total weight of the composition) Erysimum (dry extract of flowering tops) 145 1.24 Propolis (extract) 500.48 Zinc bisglycinate 16.5 0.14 Ribwort plantain (dry extract of leaves) 100.08 Marshmallow (dry extract of roots) 250.21 Concentrated strawberry juice 1400 12.0 Agave syrup 4500 38.4 Natural strawberry flavor 23.5 0.20 Potassium sorbate 250.21 Xanthan gum 200.17 Purified water 548 546.9 100

[0156]

[0157] This composition is obtained by mixing the various components according to the processes typically used for this type of preparation. The composition is then preferably in the form of an oral solution. This oral solution will be taken, preferably, by individuals with an upper respiratory tract infection, before going to sleep (at bedtime).

[0158]

Claims

Combination product comprising, as active substances, at least erysimum, propolis, zinc, ribwort plantain and marshmallow for its use to help relieve symptoms associated with upper respiratory tract infections. Combination product for use in helping to relieve symptoms associated with upper respiratory tract infections, according to claim 1, characterized in that the active substances consist of: (i) erysimum, (ii) propolis, (iii) zinc, (iv) ribwort plantain, and (v) marshmallow. Combination product for use in helping to relieve symptoms associated with upper respiratory tract infections according to claim 1 or 2, characterized in that it is in the form of a single composition comprising at least: 0.5 to 10% preferably 1 to 8% of erysimum; 0.01 to 10% preferably 0.05 to 8% of propolis; 0.001 to 1% preferably 0.01 to 0.5% of zinc; 0.001 to 3% preferably 0.05 to 2% of ribwort plantain; 0.01 to 3% preferably 0.05 to 2% of marshmallow; as a percentage by weight relative to the total weight of the composition, in a physiologically acceptable medium, the percentage being expressed as plant equivalent. Combination product for use in helping to relieve symptoms associated with upper respiratory tract infections according to any one of the preceding claims characterized in that the physiologically acceptable medium is suitable for oral administration. Combination product for use in helping to relieve symptoms associated with upper respiratory tract infections according to any one of the preceding claims, characterized in that it is in the form of an oral solution. Combination product for use in helping to relieve symptoms associated with upper respiratory tract infections according to any one of the preceding claims, characterized in that erysimum, ribwort plantain, and marshmallow are in the form of plant extracts Combination product according to at least one of the preceding claims, for its use in relieving the symptoms of subjects with an upper respiratory tract infection.