Hand-held pipetting device

Abstract

The invention relates to a hand-held pipetting device, in particular having a touchscreen, to a system having said pipetting device, to a method and to a program code. The operating concept of said pipetting device includes a function for quickly mixing samples by detecting a user input made via a mixing function input element, starting and executing the mixing process on the basis of the input, and actuating the movement element during the mixing process in such a way that a mixing step is carried out or mixing steps are carried out successively and are counted by a parameter N_mix, wherein the mixing volume VM of the sample is received into the pipetting container and subsequently dispensed again in each mixing step by the corresponding movement of the movement element.

Description

[0001] handheld pipetting device

[0002] The invention relates to a handheld pipetting device, a system for data exchange between this handheld pipetting device and an external device, and a computer program code that is executable by the handheld pipetting device.

[0003] Handheld pipetting devices are commonly used in medical, biological, biochemical, chemical, and other laboratories. They serve to transport and transfer small volumes of fluid samples, particularly for precise sample dispensing. Two well-known classes of these handheld pipetting devices differ in their respective physical principles of liquid aspiration and dispensing. Either the liquid is dispensed using the air cushion principle, or the direct displacement principle is employed. The first class of devices is called air cushion pipettes, the second class direct displacement pipettes.

[0004] In a pipetting device, the sample quantity dispensed by a single actuation can correspond to the sample quantity aspirated into the device. However, it can also be designed so that a sample quantity corresponding to multiple dispensing volumes is dispensed incrementally. Furthermore, a distinction is made between single-channel and multi-channel pipetting devices, whereby single-channel pipetting devices contain only a single dispensing / receiving channel, and multi-channel pipetting devices contain several dispensing / receiving channels, which in particular allow the parallel dispensing or aspiration of multiple samples.

[0005] The handheld pipetting devices described within the scope of the present invention are handheld computer-controlled piston-stroke pipettes with electric piston drive, also referred to as handheld electric pipetting devices or handheld electric piston-stroke pipettes.

[0006] An example of a state-of-the-art handheld electronic air cushion pipette is the Eppendorf Xplorer® and Xplorer® plus from Eppendorf AG, Germany, Hamburg; examples of handheld electronic dispensers are the Multipette® E3 and Multipette® E3x from Eppendorf AG, Germany, Hamburg.

[0007] Electric pipetting devices offer numerous advantages over non-electric pipetting devices, as a wide variety of functions can be easily implemented. In particular, electric pipetting devices simplify the execution of certain program-controlled pipetting operations by automating or semi-automating them. Typical pipetting parameters for controlling such operations using appropriate pipetting programs include the volume of liquid aspirated or dispensed, the sequence and repetitions of these operations, and, if applicable, their temporal parameters for the distribution of these operations over time. An electric pipetting device can be configured to operate in one or more operating modes.An operating mode may provide that a set of one or more pipetting parameters of the pipetting device, which influence or control a pipetting operation of the pipetting device, is automatically queried, set and / or applied.

[0008] However, many users prefer working in manual mode with an electronic pipetting device, especially when the tasks required in the laboratory are not ideally suited to a complex programmed operation. In the application tests underlying the invention, users expressed a need for more flexible use of known program functions of an electronic pipetting device. Inconvenient usability of an automated function often led to lower user acceptance. One such function is sample mixing, which is known in electronic pipetting devices as part of a programmed, semi-automated dispensing process.

[0009] When dispensing samples in chemical, biological, and medical laboratories, thorough mixing of samples and reagents is crucial to ensure that all components are evenly distributed and that the conditions for reactions and analyses are consistent. This minimizes variability and improves the accuracy and reliability of laboratory results.

[0010] Failure to thoroughly mix samples and reagents can lead to inconsistent laboratory results for several reasons: Without mixing, concentration gradients can form, resulting in uneven distribution of certain components of the sample or reagents. This leads to variable results because the amount of active substances differs in different parts of the sample. In liquids of varying density or composition, stratification can occur, with heavier components settling at the bottom and lighter ones on top. Without mixing, the sample taken will not be representative of the entire solution. Many chemical reactions require a homogeneous mixture of reagents to proceed completely and uniformly. Without mixing, reactions may remain partially incomplete, leading to inaccurate or inconsistent results. Enzymes often act in solution and require a uniform distribution of substrates.Without adequate mixing, enzymatic activity is uneven, which can lead to variable results. In biological samples such as cell cultures or when working with particle suspensions, particles can clump or aggregate if not mixed. This can distort the measurement of cell counts, particle size distributions, or other parameters. In biochemical analyses, proteins and other macromolecules can aggregate if they are not well mixed, leading to inaccurate measurements. When taking unmixed samples, there is a risk that the amount taken will not be representative of the entire sample. This can lead to inconsistent results, especially when using small volumes. Diagnostic tests such as ELISA or PCR require precise amounts of reagents and samples. Without mixing, differences in the distribution of analytes can lead to variable results and unreliable diagnoses.

[0011] The present invention is based on the objective of providing a handheld pipetting device with an efficient and ergonomically usable mixing function for mixing samples to be pipetted. The invention achieves this objective in particular by means of the pipetting device according to claim 1. Preferred embodiments are the subject of the dependent claims and can also be found in the description.

[0012] The device according to the invention is a handheld pipetting device for pipetting at least one sample, comprising a connecting section for connecting at least one pipetting container to the pipetting device, a movement element for aspirating the at least one sample into the at least one pipetting container, for holding the sample in the at least one pipetting container and for dispensing the sample from the at least one pipetting container during the execution of a pipetting process defined by pipetting parameters, an electrical control unit comprising a data processing unit programmed to control the movement element depending on the pipetting parameters, and a user interface unit for outputting information to a user and for recording user input, characterized in thatthat the user interface device has a mixing function input element and the data processing device is programmed to execute a mixing operation which includes at least one mixing step and is defined by at least one pipetting parameter which includes at least one mixing volume VM, by programming the data processing device to execute a mixing operation such that a) user input via the mixing function input element is detected and b) based on the input detected via the mixing function input element, the mixing operation is started and executed, during which the movement element is controlled such that a mixing step is performed or mixing steps are performed successively and are countable or counted by a parameter N_mix (also referred to as Nmix).wherein in each mixing step, a mixing volume VM of the sample is taken into the pipetting container by the corresponding movement of the moving element and subsequently dispensed again.

[0013] The mixing function is made immediately available via the mixing function input element, the activation of which triggers the automated execution of at least one mixing step. This provides the user with a readily available mixing function, also known as a rapid mixing function or, more simply, Quickmix. Such a mixing function can be used ergonomically and flexibly in a wide variety of application situations, making laboratory work more efficient and reproducible.

[0014] In a typical application scenario, the pipetting device according to the invention can be used as follows: i) Aspirating the liquid: a. Positioning the pipetting container, in particular the pipette tip, in the liquid of a sample container; b. Starting the mixing process by actuating the mixing function input element; the pipette will automatically aspirate the liquid up to the set volume. ii) Dispensing the liquid: the pipetting device will automatically dispense the liquid back into the sample container. This is done by a motor-driven moving element, in particular a piston, which precisely doses the liquid. iii) Repeating: The mixing step is optionally (automatically) repeated according to the user setting (for the possibilities of implementing this user setting, see below).

[0015] The advantage of the rapid mixing function is that the user can start the mixing process by pressing the mixing function input element, without having to enter the pipetting parameters required for the mixing operation. This is achieved through default values ​​for the pipetting parameters, in particular the mixing volume (MV) and a pipetting rate (v_mix), specifically an uptake rate and a dispensing rate, and optionally also a total number (N_total) of mixing steps. Further advantageous implementations for setting such parameters are described below. Compared to programmable mixing functions of known commercial pipettes, this offers the advantage of flexible and rapid application.With such programmed mixing functions, several pipetting parameters sometimes need to be entered and operating procedures performed beforehand, which is particularly time-consuming with the small user interfaces of these handheld devices. Every action the user saves leads to a noticeable reduction in laboratory work over the entire duration of pipetting.

[0016] In a preferred embodiment of the pipetting device, the mixing function input element is a control element dedicated to controlling, in particular starting and / or stopping, the mixing function. This means that in a standard state of the pipetting device, the mixing function input element always controls, in particular starting and / or stopping, the mixing function, and in particular does not trigger any other action. A standard state can be a state of the pipetting device in which the user can trigger a pipetting operation by actuating an actuating element of the pipetting device. Such a standard state can be one of several operating modes of the pipetting device, in each of which, in particular, a specific, optionally multi-step, and especially programmed pipetting operation can be triggered via the actuating element. In the standard state, the home screen can be displayed on a screen, e.g.,The touchscreen will display the pipetting device.

[0017] In another preferred embodiment of the pipetting device, the mixing function input element is a control element that serves to control, in particular to start and / or stop, the mixing function, but which also controls at least one other function of the pipetting device. In this case, the function is not fixed but configured programmatically. In particular, the mixing function input element can then optionally fulfill the function of the actuating element that controls a pipetting process, in particular initiating the aspiration into the pipetting container and / or the dispensing of the sample from the pipetting container. In such a case of dual or multiple assignment of the function of the mixing function input element, it is provided that the desired operating mode, which can be, in particular, a standard pipetting mode or a mixing function mode, is set via a mode input device.The mode input device can, in particular, be a touchscreen of the pipetting device, the activation of which can lead to a change in the active operating mode. Specifically, a swipe gesture performed on the touchscreen can lead to a change in the active operating mode. Preferably, swiping on a home screen of the touchscreen effects the change from a standard pipetting mode to the mixing function mode.

[0018] A mixing step is fundamentally characterized by the fact that the transition between sample intake and sample discharge is essentially uninterrupted, requiring only a very short period. It is accepted that the motor of a pipetting device may require a certain amount of time to change the direction of movement of the moving element, particularly the piston, in order to switch from sample intake to sample discharge. However, this typically takes less than 1 second, 500 ms, 200 ms, 100 ms, 50 ms, or less. Sample mixing should generally be as fast as possible. However, the time frame can also vary; it can be programmable, selectable by the software, and / or by the user.

[0019] In contrast to the mixing step, where the sample aspiration step is automatically followed by the sample dispensing step, in normal pipetting, i.e., in a single pipetting step, the sample aspiration and dispensing are controlled manually by a user and not automatically: the user moves the pipette attached to the connecting section of the pipetting device to the sample reservoir, immerses the pipette tip there, activates a corresponding actuating element for sample aspiration, for example by means of a rocker switch, and thus draws the sample into the pipette tip, and moves it to the target container, so that automatic dispensing is not possible, since the pipetting device does not know the time at which the sample dispensing must take place.The user specifies this by positioning the pipette tip above the target container and by actuating a corresponding actuating element, in particular by means of a rocker switch, causing the sample to be dispensed into the target container.

[0020] In principle, there are programmable pipetting devices in which automated pipetting steps can be freely defined, so that sequences of automated sample aspiration and sample dispensing are also conceivable, particularly for the purpose of mixing. However, the mixing function according to the invention is characterized by the fact that no prior programming by the user is required, but rather that, particularly after bringing the mixing function mode into effect, the mixing process can be initiated immediately by the user (step a)).

[0021] The handheld pipetting device preferably has a touch-sensitive screen for inputting the values ​​of user-definable pipetting parameters, wherein a parameter set of at least one pipetting parameter defines a pipetting operation.

[0022] The handheld pipetting device preferably has at least one operating element, also referred to as an actuating element, the actuation of which by the user starts the pipetting process defined according to the parameter set.

[0023] Preferably, the data processing device is programmed to display an input screen page on the screen for displaying and entering pipetting parameters of a parameter set of pipetting parameters, and, when the actuation of the at least one actuation element is detected, to display an output screen page on the screen instead of the input screen page for displaying pipetting parameters of the parameter set defined in the input screen page, and, when this actuation of the at least one actuation element is detected or upon subsequent actuation of one of these actuation elements, to start the pipetting operation defined according to this pipetting parameter set, wherein this or a subsequently displayed output screen page has a special button, touching which causes the output screen page to close and the display of this input screen page or another input screen page on the screen.

[0024] Preferably, the data processing device for executing the mixing process is programmed such that i) in a) it detects user input by pressing and holding the mixing function input element, and ii) either in b) after completion of a mixing step, it starts and / or executes another mixing step if, at a time after the start of the mixing process and before its completion or at the time of its completion, user input by pressing and holding the mixing function input element is detected, so that the number Nmix of mixing steps increases by 1, or iii) in b) it terminates the mixing process if, at that time, no user input by pressing and holding the mixing function input element is detected, so that the current value Nmix at that time determines a pipetting parameter Nmix_total (Nmix_total = Nmix).

[0025] The "press-and-hold" functionality of a control element typically describes a type of user interaction in which a button or touchscreen element is pressed and held for a specific time to trigger a particular action or an additional function that differs from the action performed by a short press (key press). However, to implement the invention, the mixing step is preferably triggered a) without any time delay, or at least with only a short time delay. It is possible, however, for a short time delay of less than 1 s, 500 ms, 250 ms, 100 ms, or 50 ms to be provided. In the "press-and-hold" configuration, the mixing process continues as long as the mixing function input element is pressed.At a minimum, after starting step a), a complete mixing step is executed, and preferably, an ongoing mixing step is completed even if the user releases the mixing function input element after it has started and is no longer pressed. Controlling the mixing process using a "press-and-hold" mechanism has proven to be particularly ergonomic and intuitive in application tests. Further preferred control alternatives are described below.

[0026] Paragraph ii) above means that the mixing function input element can either be permanently pressed by the user to perform a further mixing step, and / or can optionally be interrupted in between, as long as an activation of the mixing function input element is detected at a relevant, programmed time between starting and ending - this control option can be particularly ergonomic for experienced users.

[0027] The parameter Nmix_total mentioned in paragraph iii), which contains the total number of steps counted using the counting parameter Nmix (=N_mix) during the ongoing or completed mixing process, is preferably stored in an optional data storage device of the pipetting device and / or preferably documented in a log file. Alternatively or additionally, at least one further pipetting parameter applied during mixing is stored and preferably documented in a log file, in particular the mixing volume VM and / or a pipetting rate vm.

[0028] The mixing function input element is preferably configured to allow the mixing function input element to be pressed along a deflection path, to be held in place, and, upon release of the mixing function input element, to allow the spring element to return to its original position along the deflection path. The deflection path can be linear or curved. The mixing function input element can include a tensioning device, in particular an elastic element, especially an elastomeric part or a spring, which is tensioned when pressed and which relaxes when the mixing function input element is released, thereby returning the mixing function input element to its initial position. The mixing function input element can be a button, in particular a spring-loaded one, or a slider, in particular a spring-loaded one, or a lever, in particular a spring-loaded one.The mixing-function input element can be touch-sensitive and is preferably configured to measure pressure by measuring upon contact, particularly by a user's finger. In this "touch-and-hold" case, the same functionality as "press-and-hold" is enabled. This is achieved in particular by means of a touchscreen or an electrically operated, especially capacitive, sensor field.

[0029] Preferably, the data processing device for executing the mixing process is programmed to automatically and successively continue the mixing process by automatically increasing the number Nmix of the mixing steps, and, if a new user input is detected during the mixing step via the user interface device, in particular the mixing function input element, to terminate the mixing process after the mixing step has been carried out, so that the current value Nmix at the time of the new input determines the pipetting parameter Nmix_total (so that Nmix_total = Nmix).

[0030] This alternative way of controlling the mixing function is called "Quickmix via activation and deactivation".

[0031] The total number of Nmix_total steps in the mixing process is preferably not definitively determined when the input used to start the mixing process is received. Instead, this total number is initially undefined when using "press-and-hold" or "Quickmix via activation and deactivation," depends on the user, and is only known once the mixing process has been terminated by the user. This occurs at the latest when the user ends or exits an (optional) mixing function mode, particularly when switching back to a standard pipetting mode.However, there is also a preferred alternative control method for the mixing function, in which the total number, particularly as a maximum number, is predetermined: Preferably, the data processing device for executing the mixing operation is programmed to automatically perform the mixing operation using a predefined maximum number Nmix_max of mixing steps, and to automatically terminate the mixing operation after Nmix_max of mixing steps have been executed. In this case, the quick mixing function is a user-triggered but otherwise predefined operation, which is preferably optionally abortable, so that Nmix_total = Nmix_max, though not necessarily.

[0032] Pipetting device according to one of the preceding claims, wherein the user interface device has a mode input device different from the mixing function input device, and the data processing device is programmed to perform the mixing operation, i) to detect user input via the mode input device, and ii) to activate a mixing function mode of the pipetting device based on the input via the mode input device, and iii) to perform steps a) and b), in particular only when the mixing function mode has been activated.

[0033] Such a mode input device can be implemented in different ways, in particular by means of one of the following controls: touchscreen; dial; button; sensor field; slider; accelerometer; voice input capability.

[0034] In a preferred embodiment of the pipetting device, the mode input device is implemented by means of a touchscreen. Switching from the operating mode to the mixing function mode can be accomplished via programmed gesture recognition, in particular by detecting a swipe gesture on the touchscreen. Switching from the operating mode to the mixing function mode can also be accomplished by touching a programmed control field on the touchscreen. Preferably, the mode input device alternatively comprises: i) a touch-sensitive screen (touchscreen) of the user interface device, which is operated by a gesture constituting the input, wherein the gesture is in particular a swipe of the screen, in particular in a predefined direction, in particular a direction perpendicular to the longitudinal axis of the pipetting device, in particular a direction having four sides.cuboidal screen in a side-parallel or side-perpendicular direction, in particular a direction to the right, wherein the swiping leads to the activation of the shuffle function mode particularly when - preferably exactly or only when - the screen page currently displayed on the screen is the home screen; ii) or a control panel in a screen page displayed by a touch-sensitive screen (touchscreen) of the user interface device; iii) or a sensor element, in particular a switch, button or a capacitive measuring field, by means of which the user's input can be detected.

[0035] Preferably, the pipetting device has at least one actuating element that can be activated by a user's finger pressure or finger contact, and whose actuation initiates a pipetting process defined according to a parameter set of pipetting parameters when the mixing function mode is not activated, particularly in a standard pipetting mode. Such an actuating element constitutes the mixing function input element when the mixing function mode is activated. This dual function of the mixing function input element, or actuating element, with the two selectable functions "pipetting" and "mixing" allows a single physical control element to be used to perform two functions. This offers advantages in terms of usability, flexibility, design, and manufacturing costs.

[0036] It is possible that the data processing device is programmed to start the mixing process in step b) with or without a prior safety check if, in mixing function mode, an actuation of at least one B mixing function input element or actuation element according to a) is detected.

[0037] Preferably, the data processing device is programmed to log the total number Nmix_total of the mixing steps completed during the mixing process by capturing the parameter Nmix_total as part of log data and, in particular, storing it in a data storage device, wherein the log data also includes, in particular, the pipetting parameters VM (mixing volume) and vm (pipetting rate during the mixing process) used in the mixing process.

[0038] Preferably, a parameter set of pipetting parameters fully defines a planned and / or a previously performed pipetting operation and includes at least one pipetting parameter VP that defines a pipetting volume of the pipetting operation and is referred to as the pipetting parameter "pipetting volume", wherein the data processing device for executing the mixing operation is programmed to derive the mixing volume VM, which is referred to as the pipetting parameter "mixing volume", from the at least one pipetting parameter VP defining the pipetting volume.

[0039] Preferably, the data processing device is programmed to determine the mixing volume VM from a predefined function VM(VP), which assigns a value of the mixing volume VM to each value of the pipetting parameter VP. This assignment can preferably be carried out using a predefined assignment table VM(VP), in particular by reading values ​​VM as a function of VP from a database containing value pairs (VP ​​ / VM)i stored in a data storage device of the pipetting device; or preferably, this assignment can be carried out by a mathematical operation performed by the control device, which calculates VM(VP) according to a predefined formula: preferably VM(VP) = c * VP, where preferably c is a factor less than or equal to 1, preferably c <= 1.0 or c <= 0.9 or c <= 0.8, and where in particular c >= 0.05 or c >= 0.1 or c >= 0.5.

[0040] Preferably, the data processing device for performing the mixing operation is programmed to use a predefined mixing volume VM, which is referred to as the pipetting parameter “predefined mixing volume”, wherein VM has been previously set by the user or the manufacturer and stored in a data storage device of the pipetting device.

[0041] Preferably, the data processing unit for executing the mixing process is programmed to derive and use a mixing volume VM from a predetermined nominal volume VN of the pipetting containers used with the pipetting device, wherein VN is defined by the manufacturer and stored in a data storage device of the pipetting device. The derivation can be performed analogously to derivation from the pipetting volume.

[0042] It is also preferred that the data processing device be programmed to provide a manual input for user-defined setting of the mixing volume or any other pipetting parameter relevant to mixing, in particular a pipetting rate to be used during mixing or a total number of mixing steps.

[0043] Preferably, the data processing device is programmed to i) display a screen page on a touch-sensitive screen of the user interface device before and / or during and / or after the execution of a pipetting operation, which in particular serves as a mode input element by gesture control or which contains a control panel for activating a mixing function mode, and / or ii) display a screen page on a screen of the user interface device before and / or preferably during and / or after the execution of the mixing operation, which in particular displays the values ​​of the pipetting parameters VM and Nmix and / or Nmix_total.

[0044] The display of the screen page in i) can occur at least after the execution of a pipetting operation or after the execution of a substep of a multi-step pipetting operation.

[0045] Preferably, the screen page in i) is an input screen page (“set screen” or home screen) for displaying and entering pipetting parameters of a parameter set of pipetting parameters, and wherein the data processing device is programmed to display an input field on the input screen page that shows the value of the pipetting parameter VP (pipetting volume), and touching this field on the screen opens an input interface that allows the user to change or enter the value of at least one pipetting parameter VP. Preferably, the screen page in i) is an output screen page (“do screen”).

[0046] Preferably, the data processing device is programmed, in particular with regard to the possibility of a display as a result of actuation of the mode input device, c1) as a result of actuation of the mode input device, to display a screen page with a display element that outputs the pipetting parameter (mixing parameter) VM, wherein this display preferably occurs together with the activation of the mixing function mode, in particular substantially simultaneously, wherein the display element is preferably an input field, the touching of which opens an input interface on the screen that allows the user to change the value of the mixing volume VM; and / or c2) to display a display element on the screen that outputs a pipetting speed vm to be used in the mixing step, wherein the display element showing the pipetting speed is preferably an input field, the touching of which opens an input interface on the screen.which allows the user to change the pipetting rate value vm. The screen page mentioned in d) is also referred to as the mixing function screen page. It can, alternatively or additionally, also include a display element for showing and, optionally when implemented as an input field, for entering a total number Nmix_total of mixing steps. Furthermore, it can, alternatively or additionally, include a display element that outputs information about the progress of the time period, in particular by displaying countdown time units, e.g., seconds, of this period. This display element can also be implemented as an input field, the touching of which provides an interface for entering a time parameter t_mix.which specifies the total time of the mixing process or the time to be used for a mixing step. The data processing unit can be programmed to determine the mixing volume VM and / or the pipetting rate vm. This can be advantageous if, for a user, controlling the reproducibility of mixing results essentially depends on defining a movement time of a liquid sample. The time parameter can also be stored and / or documented in a data storage unit.

[0047] Preferably, the data processing device is programmed to perform at least one of the following steps, each of which is executed after completion of a mixing step of a multi-step mixing process carried out according to step b) - this applies in particular to the screen page displayed during the mixing process: d1) Display of a screen page in a screen of the user interface device, wherein the screen page has a display element that outputs the pipetting parameter VM, wherein preferably the display element is an input field, touching which opens an input interface in the screen that allows the user to change the value of the mixing volume;d2) Display of an indicator on the screen that outputs a pipetting rate to be used in the mixing step, wherein preferably the indicator displaying the pipetting rate is an input field, touching which on the screen opens an input interface that allows the user to change the value of the pipetting rate; d3) Pause and resume the mixing process if, during or at the end of the mixing step, a renewed actuation of the mixing function input element is detected; d4) Immediate resumption of the mixing process if a continued actuation of the mixing function input element is detected, e.g., in the case of press-and-hold of the mixing function input element; d5) Output of a step number Nmix = (1 , ... , Nmix_total) of a multi-step mixing process with the total number Nmix_total of mixing steps in a display field on the screen;d6) Display of an input field on the screen, touching which leads to the termination of the mixing function mode and / or the mixing process.;

[0048] Preferably, the data processing device is programmed to display a mixing function screen page on a screen of the user interface device, showing the total number Nmix_total of mixing steps of the mixing process detected during the activity of the mixing function mode, wherein i) it is possible to continue the mixing process so that the total number Nmix_total is further increased; ii) the total number parameter Nmix_total is not set to zero and the counter parameter is not set to zero when a release of the mixing function input element is detected during a press and hold of the mixing function input element after the start of the mixing step and up to a point before the end of the mixing step, and in particular, the mixing process is continued when a further press and hold of the mixing function input element is detected after this point or at the end of the mixing step.

[0049] Preferably, the data processing device is programmed to perform one of the following steps, relating to the screen displayed at the end of the mixing process, after completion of the total number Nmix_total of mixing steps of the mixing process during the mixing function mode: e1) Keep the mixing function mode active, permanently or for a period of time, so that until the mixing function mode is terminated, the detection of the actuation of the mixing function input element results in the execution of a further mixing step; e2) End the mixing function mode.

[0050] Preferably, the data processing device is programmed to perform step e1), in which the mixing function mode is kept active for a period of time, and to display a screen indicator providing information about the progress of the period of time, in particular by displaying countdown time units, e.g. seconds, of that period of time.

[0051] Preferably, the data processing device is programmed to perform step e1) in which the blending mode is kept permanently active, and i) an input field is displayed on the screen, touching which terminates the blending mode, or ii) a gesture, in particular a swipe, is detected which terminates the blending mode, in particular closes the blending screen page and in particular returns to an input screen page, in particular a home screen.

[0052] Preferably, the data processing device is programmed to perform one of the following steps after completion of the total number Nmix_total of mixing steps of the mixing process during the mixing function mode: e3) in the case of an incomplete, multi-step pipetting process:

[0053] • Display of an output screen page to show pipetting parameters of the parameter set on the screen and

[0054] • Switching to output mode, in which actuation of at least one actuating element results in the automatic execution of the next pipetting step; e4) in the case of a completed pipetting operation:

[0055] • Display of an input screen page for displaying and entering pipetting parameters of a parameter set of pipetting parameters on the screen and

[0056] • Switching to input mode, in which, in particular, the actuation of at least one actuating element results in the switch from input mode to output mode.

[0057] Preferably, the data processing device is programmed to display a mixing function screen page in a screen of the user interface device, showing the total number Nmix_total detected during the activity of the mixing function mode, wherein i) it is possible to continue the mixing process so that the total number Nmix_total is further increased; ii) the total number parameter Nmix_total is not set to zero and / or the counter parameter Nmix is ​​not set to zero when a release of the mixing function input element is detected during a press and hold of the mixing function input element after the start of the mixing step and up to a point before the end of the mixing step, and in particular, the mixing process is continued when a further press and hold of the mixing function input element is detected after this point or at the end of the mixing step.

[0058] Preferably, the data processing device is programmed to pause the movement of the moving element for a duration t_stop between two mixing steps during a mixing operation, where in particular 30 ms ≤ t_stop ≤ 700 ms, in order to provide the user with haptic feedback of the completed mixing step. This can occur, in particular, between mixing steps belonging to two different blocks of mixing steps. A block can contain a number NB ≥ 2 of block mixing steps, e.g., NB = 3, 4, or 5. In addition to or as an alternative to pausing, an optical and / or acoustic signal can also be output via the user interface device to signal the start and / or end of a mixing step or block.

[0059] Preferably, the mixing function input element is operated via a first rocker half of a rocker element, or this rocker half is the first rocker half, wherein the data processing device is preferably programmed to also detect the actuation of a second rocker half of the rocker element during the execution of a mixing process, wherein this actuation leads to the immediate stop of the movement element, in particular even if the mixing step is not yet complete.

[0060] Preferably, the data processing device is programmed such that, in mixing function mode, a single press and immediate release (i.e., a tap) of the mixing function input element triggers exactly one complete mixing step. Preferably, the data processing device is programmed such that, in mixing function mode, a single press and immediate release (i.e., a tap) of the mixing function input element triggers a total number Nmix_total of complete mixing steps. Preferably, the data processing device is programmed such that, in mixing function mode, a single press and immediate release (i.e., a tap) of the mixing function input element triggers one or more mixing steps for a total time period t_mix, or triggers exactly one mixing step for a total time period t_mix.

[0061] The invention also relates to a computer program code for the execution of a mixing process by a programmable, handheld pipetting device for pipetting at least one liquid sample, wherein the pipetting device comprises:

[0062] * a connecting section for connecting at least one pipetting container to the pipetting device,

[0063] * a moving element for aspirating the at least one sample into the at least one pipetting container, holding the sample in the at least one pipetting container and dispensing the sample from the at least one pipetting container during a pipetting process,

[0064] * an electrical control device comprising a data processing unit programmed to control the motion element depending on the pipetting parameters,

[0065] * A user interface device for outputting information to a user and for capturing user input, comprising a mixing function input element, wherein the program code, when executed by the data processing device of the handheld pipetting device, results in a) capturing user input via the mixing function input element and b) initiating and executing the mixing process based on the input captured via the mixing function input element, during which the movement element is controlled to perform one or more mixing steps successively, counted by a parameter N_mix, wherein in each mixing step the mixing volume VM of the sample is taken into the pipetting container and subsequently dispensed by the corresponding movement of the movement element.

[0066] Further optional features of the program code can be found in the description of the pipetting device according to the invention, including all its configuration options. Such program code is particularly suitable for use in a handheld pipetting device that does not yet have the rapid mixing function according to the invention, but which is configured as a handheld pipetting device according to the invention by implementing the program code.

[0067] The invention also relates to a method for performing a mixing function operation by means of a programmable, handheld pipetting device for pipetting at least one liquid sample, wherein the pipetting device comprises: * a connecting section for connecting at least one pipetting container to the pipetting device,

[0068] * a moving element for aspirating the at least one sample into the at least one pipetting container, holding the sample in the at least one pipetting container and dispensing the sample from the at least one pipetting container during a pipetting process,

[0069] * an electrical control device comprising a data processing unit programmed to control the motion element depending on the pipetting parameters,

[0070] * A user interface device for outputting information to a user and for capturing user input, comprising a mixing function input element, wherein the method comprises the computer-implemented steps, in particular executable by a data processing device of a handheld pipetting device, namely that a) user input via the mixing function input element is captured and b) based on the input captured via the mixing function input element, the mixing process is started and executed, during which the movement element is controlled such that a mixing step is performed or mixing steps are successively performed and counted by a parameter N_mix, wherein in each mixing step the mixing volume VM of the sample is taken into the pipetting container by the corresponding movement of the movement element and subsequently dispensed again.

[0071] Further optional features of the method can be found in the description of the pipetting device according to the invention, including all its configuration options. When automated pipetting processes are mentioned, semi-automated pipetting processes are always also meant, unless the specific context contradicts this. Performing an automated pipetting process always involves at least one user action that triggers the automated pipetting process, usually by actuating a control element of the pipetting device. Semi-automated pipetting processes in certain application scenarios may, for example, require that a user, in addition to starting a pipetting process divided into sub-processes, also initiates at least one sub-process by actuating a control element.The automated pipetting operations of a specific application scenario can, in certain embodiments of the pipetting device, be defined by a set of pipetting parameters. These parameters are set by the user before starting an automated pipetting operation using the device's user interface, and / or are selected from default settings and / or loaded from memory. Typically, the user interface of such pipetting device embodiments features a selection option, such as a dial or a list of selectable fields on a touchscreen, through which a so-called "operating mode" can be selected, representing the specific application scenario.in which the entire set of pipetting parameters belonging to this specific application scenario is selected and which the user can set before starting the associated automated pipetting process. The automated pipetting process then runs according to a pipetting program predefined as the operating program for this operating mode.

[0072] In a preferred embodiment, the pipetting device or data processing unit is programmed so that the user can manually define an automated pipetting process by selecting pipetting parameters, and thus, in particular, define a set of pipetting parameters (pipetting parameter set) for a user-defined pipetting process. This pipetting parameter set can partially or completely correspond to a predefined pipetting parameter set of an operating mode. Pipetting parameters of a pipetting process relate to...Preferably quantify the volume to be pipetted, the step of aspirating the sample into a pipetting container connected to the piston-stroke pipette, or the step of dispensing the sample from this pipetting container, optionally the sequence and repetitions of these steps, and optionally temporal parameters for the temporal distribution of these processes, in particular the temporal variation of such processes, especially the speed and / or acceleration of aspirating or dispensing the sample. In this embodiment, the automated pipetting process runs according to a pipetting program that is fully defined according to these user-defined pipetting parameters.

[0073] The handheld pipetting device according to the invention is preferably designed to be used for carrying out at least one pipetting operation according to at least one parameter set of at least one, or at least two, or at least three pipetting parameters, in particular to be used in at least one predetermined operating mode according to a predetermined parameter set of the pipetting device or in a user-defined parameter set. In each operating mode, preferably one parameter set of pipetting parameters (pipetting parameter set) is provided, the pipetting parameters of which are optionally not selectable by the user or optionally at least partially selectable by the user and supplemented by further pipetting parameters.

[0074] A pipetting process typically involves drawing a specific sample quantity from a starting container into a pipetting container, particularly the pipette tip, connected to the piston-stroke pipette, and / or dispensing it into a target container, especially in a metered dose, according to a pipetting program. A pipetting process can preferably be controlled by at least one, two, three, or preferably several pipetting parameters, with which the pipetting process, or a function or component thereof, can be influenced or defined in the desired manner.

[0075] Pipetting parameters for controlling a pipetting process preferably relate to or quantify the volume to be pipetted, during the step of aspirating the sample into a pipetting container connected to the piston-stroke pipette or during the step of dispensing the sample from this pipetting container, optionally the sequence and repetitions of these steps, and optionally temporal parameters in the temporal distribution of these processes, in particular also the temporal change of such processes, especially the speed and / or acceleration of aspirating or dispensing the sample, or the number of pre-wetting steps and optionally the volume aspirated and dispensed in each case.

[0076] These pipetting parameters are preferably at least partially and preferably completely selected and / or entered by the user, in particular via the at least one control element of the user interface device of a piston-stroke pipette or an external data processing device.

[0077] The pipetting process is preferably uniquely defined or determined by the pipetting parameter set. This pipetting parameter set is preferably at least partially and preferably completely selected and / or entered by the user, in particular via the operating device of the pipetting apparatus or the external data processing device.

[0078] However, it is possible that a pipetting operation is not uniquely defined by the pipetting parameter set; in this case, the pipetting device is specifically configured, or the data processing device is programmed, to automatically supplement the pipetting parameter set with at least one further pipetting parameter, particularly depending on the (selected) pipetting parameters. It is possible and preferred that at least one pipetting parameter is not defined by the user, but is, for example, predefined by the pipetting device, either by being stored in a data memory or by being automatically determined.

[0079] Preferably, at least one pipetting parameter is provided with which the number of immediately successive or indirectly successive pipetting volumes is determined, preferably at least one pipetting parameter with which the number of aspiration steps and / or dispensing steps and preferably also the respective associated pipetting volumes, the respective associated pipetting velocities and / or accelerations, and / or the respective associated time intervals between the steps are determined.

[0080] Typical pipetting parameters that can be used to manually define user-defined pipetting operations can be found in the following description of typical application scenarios for automated pipetting operations:

[0081] A typical application scenario for pipetting devices, designed as a semi-automated process, is the dispensing (abbreviated as "DIS") of a volume aspirated into the pipetting container (pipette tip or dispenser tip). Each partial dispensing, e.g., dispensing a total sample of 1 ml from a pipetting container into a total of ten separate target containers of a microtiter plate, requires the user to position the pipetting device above a reservoir containing the sample liquid to be dispensed, immerse the tip of the pipetting container in the reservoir liquid, aspirate a starting volume by pressing a control, trigger a reversal stroke by pressing a control, thereby returning the system to a defined starting position, position it above the first target container, and initiate the electrically driven dispensing of a metered partial volume of 0.1 ml by pressing a control.The pipetting device is moved and positioned above the next target container of the microtiter plate. The electrically driven dispensing of a metered partial volume of 0.1 ml is initiated again by actuating a control element. These manually performed steps (positioning, triggering), followed by the automated partial dispensing of 0.1 ml of sample (out of a total of 10 partial dispensing steps), are repeated eight more times. The metered dispensing of the partial volumes is carried out according to predefined pipetting parameters, including one, several, or all of the following: the total volume of the sample to be dispensed, the partial volumes of the sample to be dispensed and / or the number of dispensing steps to dispense equal partial volumes, the sample aspiration rate and / or a potentially different sample dispensing rate, and the volume of a reversal stroke.The volume of an over-stroke. The dispensing function is particularly suitable for quickly filling a microtiter plate with a reagent liquid and can be used, for example, to perform an ELISA.

[0082] Preferably, one application scenario involves the "Automatic Dispensing" (ADS) of a sample. Associated operating parameters preferably include: the volume of the individual sample, specifically the pipetting volume during one of several dispensing steps; the number of dispensing steps; the duration of the time interval according to which the dispensing steps are automatically performed sequentially at constant intervals – the time interval can define these intervals or, for example, the delay between the end and beginning of successive dispensing steps; the rate of sample intake; and the rate of sample dispensing. This dispensing function is even more convenient for filling a microtiter plate, as the user does not have to repeatedly trigger a dispensing step by actuating, for example, pressing a button, but rather the dispensing occurs automatically after the start of automatic dispensing.The execution of the operating program associated with such a pipetting parameter set can include automatic dispensing, provided that the corresponding program is run at least as long as an actuating element is continuously pressed, e.g., by holding down a button continuously. This is advantageous, for example, for long dispensing series or reactions where precise adherence to a time window is required. The automatic dispensing function is even more convenient for filling a microtiter plate, as the user does not have to manually trigger each individual dispensing step; this occurs automatically, which can be used, for example, to perform an ELISA.

[0083] Preferably, one application scenario involves the "pipetting" (pip) of a sample. Associated pipetting parameters include, in particular: the volume of the sample to be pipetted; the rate of sample aspiration; and the rate of sample dispensing.

[0084] Preferably, one application scenario involves the "pipetting followed by mixing" (P / Mix) of a sample. Associated pipetting parameters are preferably: the volume of the sample to be aspirated and / or dispensed; the mixing volume; the number of mixing cycles; the sampling rate; and the dispensing rate. The "pipetting followed by mixing" function is recommended, for example, for pipetting very small volumes. If a dispensing volume of < 10 L is selected, it is recommended to flush this volume into the respective reaction liquid. This is possible by automatically initiating a mixing motion after the liquid has been dispensed. The mixing volume and the number of mixing cycles are predefined. One application for this operating mode is, for example...The dispensing of a liquid that, due to its physical properties, is more difficult to dose than water, the residue of which in the pipetting container, especially the pipette tip, is then flushed out of the container or pipette tip using the previously dispensed liquid. Another application would be the immediate mixing of the dispensed liquid with the dispensed liquid. This operating mode is advantageous, for example, when adding DNA to a PCR mixture.

[0085] Preferably, an application scenario involves the "multiple aspiration" of a sample, also referred to as "reverse dispensing" or "ASP" for aspiration. Associated pipetting parameters are preferably: the volume of the sample(s) to be aspirated; the number of samples; the aspiration rate; and the dispensing rate. The function serves to aspirate a quantity of liquid multiple times and dispense the total quantity. Multiple refilling of the pipetting container in a single operation is not provided. The rate is the same for all samples. In the embodiment, the following preferably occurs: Starting from the home position, the pipetting device aspirates a partial volume by actuating the first type of operating device. After aspirating the last partial volume, the pipetting device preferably issues a warning message, which must preferably be acknowledged by the user by actuating the second type of operating device.Upon the next actuation of the second type of control device, the entire volume is dispensed again. For actuation of the first or second type, the control device preferably has at least two operating elements: one for inputting an operating signal of the "first type" to the control device, and one for inputting an operating signal of the "second type" to the control device. The control device may, in particular, have a rocker arm that is pivotable about an axis perpendicular to the longitudinal axis of the pipetting device, between a first signal-trigger position ("rocker up") for actuation of the first type and a second signal-trigger position ("rocker down") for actuation of the second type.

[0086] Preferably, one application scenario involves the dilution of a sample. Associated pipetting parameters are preferably: the sample volume; the air bubble volume; the diluent volume; the aspiration rate; and the dispensing rate. The maximum diluent volume is calculated as nominal volume minus (sample + air bubble). This function is used to aspirate a sample and a diluent, separating them with an air bubble, and dispense the total volume. The rate is the same for all partial volumes. In this embodiment, the following preferably occurs: Starting from the home position, the pipetting device first aspirates the diluent volume, then the air bubble, and finally the sample. Each aspiration is preferably triggered separately by actuating the operating device of the first type. The total volume is then dispensed in one go.

[0087] Preferably, one application scenario involves the sequential dispensing (SeqD) of samples. Associated pipetting parameters are preferably: the number of samples (preferably up to a fixed maximum number Nmax of preferably 5 ≤ Nmax ≤ 15, preferably Nmax = 10); the individual volume of each sample; the aspiration rate; and the dispensing rate. This function is used for the sequential dispensing of freely selectable volumes Nmax, preferably without the need for multiple refills of the pipetting container. The rate is the same for all samples. The number of samples is preferably the primary parameter for inputting the individual volumes. The pipetting device must preferably always check whether the maximum volume of the pipetting device is exceeded when the volumes are input; if necessary, a warning message is issued.After all parameters have been entered, the pipetting device, upon activation of the first type of control, aspirates the total volume, and upon activation of the second type of control, dispenses individual volumes. All subsequent processes preferably behave like normal dispensing. Preferably, one application scenario involves the "sequential pipetting" (SeqP) of samples. The associated pipetting parameters are preferably: number of samples (preferably up to a fixed maximum number Nmax of preferably 5 ≤ Nmax ≤ 15, preferably Nmax = 10); individual sample volume; aspiration rate; dispensing rate. This function is used for pipetting freely selectable volumes up to Nmax, which are programmed before start and whose sequence is fixed. The rate is preferably the same for all samples. However, the rate can also be set differently.The function operates according to the pipetting process. The previously entered volumes are processed in the programmed sequence. After dispensing, a control element, such as a button press, determines whether the next sample should be taken up, or whether a "blowout" should be performed before the next sample is taken up (i.e., a complete and safe expulsion of the remaining sample from the pipetting container by means of an overstroke), and / or whether the pipetting container should be changed.

[0088] Preferably, one application scenario involves the reverse pipetting (rPip) of samples. Associated pipetting parameters are preferably: the volume of the individual sample; the aspiration rate; the dispensing rate; and counter activation. With this rPip function, more volume than the intended dispensing volume is aspirated. This is achieved by lowering the piston before liquid aspiration, by means of a second type of actuation, i.e., by pressing a button or using a rocker switch, until it reaches the lower position of a blowout, i.e., an overstroke of the piston that exceeds its position during a single pipetting stroke. At the start of volume aspiration, the pipetting device aspirates the volume of the blowout and the set volume. To eliminate backlash in the drive mechanism in the dispensing direction, the pipetting device performs an additional stroke, which is immediately dispensed.This is similar to dispensing, but preferably takes place with automatic dispensing of the discard stroke at maximum speed.

[0089] In the execution of the "rPip" application scenario, the following preferably occurs: the piston of the pipetting device (or the dispenser tip) automatically moves to the blowout position and stops in the lower position. Secondly, the first type of control is activated: the piston moves upwards by the blowout distance and by the stroke for the pipetting volume. Thirdly, the second type of control is activated: the piston moves downwards by the stroke for the pipetting volume and stops before the blowout. Fourthly, the second type of control is activated twice: the piston performs the blowout and stops in the lower position. Alternatively to "fourth," the first type of control is activated: the piston moves upwards by the pipetting stroke. The "rPip" mode is particularly suitable for pipetting plasma, sera, and other liquids with a high protein content. The "Pipetting" mode is particularly suitable for aqueous solutions.The "rPip" mode is particularly suitable for solutions containing wetting agents to minimize foaming during dispensing into the target vessel. The liquid is aspirated, especially with excess volume (blowout volume). This excess volume is typically not part of the dispensed volume and is preferably not dispensed into the target vessel. Particularly when the same sample is reused, the excess volume can remain in the tip. When a different liquid is used, the excess volume and / or preferably the pipetting chamber is discarded.

[0090] A pipetting parameter set preferably controls an operating program, in particular a control program, for carrying out the desired pipetting process. The control program can be implemented in the form of electrical circuits of the control device and / or by executable program code suitable for controlling a control device that is program-code controllable and preferably programmable.

[0091] The pipetting device or an external data processing device is preferably configured to automatically check the user-entered pipetting parameter values ​​and compare them with a permissible range for the respective parameter. If the user-entered parameter value is outside the permissible range, the input is either rejected, a warning is displayed on the screen and / or audibly, or a default value is set (e.g., the minimum or maximum value, the last permissible value entered), or an automatically corrected value is used.Preferably, the pipetting device has at least one touch-sensitive or non-touch-sensitive screen and / or preferably a number of at least partially predefined display pages (also referred to as "screen pages") stored in the pipetting device in the form of display page data, which can be displayed on one screen or distributed across several screens, preferably filling the entire screen. Preferably, the screen area is substantially rectangular, but square is also possible. In the case of a non-square rectangle, it is particularly preferred that the shorter side of the rectangle is arranged perpendicular to the longitudinal axis A of the pipetting device. This allows for a longer list of entries, especially lines, arranged vertically. It is also preferred that the longer side of the rectangle is arranged perpendicular to the longitudinal axis A of the pipetting device.In this way, an arrangement of adjacent entries, especially columns, could be longer.

[0092] The data processing unit is preferably programmed to display a graphical user interface (GUI) on the screen. In the subsequent description of the GUI, the phrase "the data processing unit is programmed to" is sometimes omitted, and only the GUI and its functionality are described. However, it is always implied that the data processing unit is programmed to implement the corresponding GUI and its functionality. This implementation is a routine task for someone skilled in the art.

[0093] The GUI includes, at least preferably, the display of a screen page (in particular, a "home screen") that shows pipetting parameters from a set of pipetting parameters. The data processing device is therefore programmed to display a screen page showing pipetting parameters from a set of pipetting parameters. The expression "a pipetting parameter is displayed on the screen" means that the currently set value of the pipetting parameter is shown. Additionally, a description of the pipetting parameter may be displayed, in particular a text description, a characteristic pictogram, or a physical unit of the quantity described by the pipetting parameter, if the pipetting parameter involves one, e.g., "pL" for a volume.However, the expert can also know or learn from the context which pipetting parameter a displayed value is assigned to, even if a description is missing on the screen.

[0094] The data processing unit is specifically programmed to display a start screen, also known as the home screen (analogous to the homepage in internet browsers). It is preferred that multiple or numerous user inputs to the GUI lead back to this home screen. This home screen can be advantageously used to display the entire parameter set of a user-defined pipetting process—or one adopted from a pre-stored application scenario—and to allow settings of the associated pipetting parameters. The home screen is displayed, in particular, after the pipetting devices are switched on, especially immediately after power-on. It is possible that purely informational pages, such as a company logo, device information, etc., may be displayed before the home screen appears.Switching on can be achieved via user operation of the display or an actuator, or can be triggered by a sensor measurement, e.g., an accelerometer, motion sensor, proximity sensor, etc. Such a home screen has proven to be an intuitively understandable central element of the pipetting device's operating concept for the user.

[0095] The home screen preferably displays the pipetting parameters of the currently valid parameter set as the default selection. In addition, the data processing system can be programmed to display one, several, or all of the following on the home screen:

[0096] • After switching on the pipetting device, the pipetting parameters of a basic parameter set are displayed;

[0097] • After switching on the pipetting device, the pipetting parameters of the last set basic parameter set are displayed;

[0098] • After switching on the pipetting device, the pipetting parameters of the last set basic parameter set are displayed, which was at least partially or completely executed, or which was only set but not executed;

[0099] • After a period of inactivity of the pipetting device – particularly after a possible standby mode – the pipetting parameters of a basic parameter set may be displayed; this basic parameter set is specifically the pipetting parameter set displayed after the pipetting device is switched on. "Inactivity" can mean that no user operation or display touch has been detected on the device for a predefined period – predefined according to factory settings or defined by the user – and / or that an optional sensor (e.g., an accelerometer, motion sensor, proximity sensor) of the pipetting device has not detected any movement and / or approach of a user. The standby mode can be activated automatically after a predetermined period of inactivity.

[0100] • After a period of inactivity of the pipetting device - especially after a possible standby mode - the pipetting parameters of the last set basic parameter set are displayed;

[0101] • After a period of inactivity of the pipetting device - especially after a possible standby mode - the pipetting parameters of the last set basic parameter set are displayed, which was at least partially or completely executed or which was set but not executed.

[0102] Preferably, the screen includes at least one first input tile that displays the value of at least one—or exactly one—first pipetting parameter of a parameter set, in particular a basic parameter set, that defines a pipetting operation, especially a basic pipetting operation. The number of input tiles displayed on the screen preferably corresponds to the number of pipetting parameters of the parameter set. The basic parameter set preferably includes at least one, preferably at least two, preferably at least three, preferably at least four, preferably at least five, preferably up to ten, or more pipetting parameters.In particular, the data processing device is programmed to start the pipetting process belonging to the pipetting parameter set when the user - with the screen or home screen displayed - activates any operating element.

[0103] Preferably, touching an input tile on a screen page, in particular the first input tile, opens an input interface that allows the user to input the value of the associated pipetting parameter, in particular the at least one first pipetting parameter.

[0104] An input tile is understood to be a marked input area on the screen displayed on the touchscreen, touching which constitutes an input. The programming preferably initiates a subsequent action as a result of this touch, in particular the display of an input interface. The detection area, which the control program interprets as input for this input tile, may differ from the marked area, e.g., be larger, but preferably the marked area, i.e., the visible input tile, corresponds to the detection area. If the detection area is larger than the marked area, incorrectly located touches are also registered as input.If the detection area is smaller than the marked area, the user is trained to correctly locate touches on the input tiles, and the distance between adjacent input tiles can be reduced without increasing the number of incorrect locations, thus making better use of the available input / output area. These tolerance solutions are acceptable or promote user satisfaction as long as the touch does not enter the detection area of ​​another input tile or input field on the screen. The visible input tile is preferably a substantially rectangular area, since rectangles make the best use of the available area for input and output on a substantially rectangular display. However, such an area can also be other shapes, e.g., hexagonal, circular segment, polygonal, and / or rounded.Preferably, the width b of an input tile extends over a fraction X of the total width B of the screen – viewed particularly perpendicular to a longitudinal axis A through the pipetting device. Preferably, this fraction is 0.8 < x < 1, preferably 0.9 < x < 1, preferably 0.95 < x < 1. The large width of the input tiles makes input comfortable. Here, b = B * x.

[0105] Preferably, the background of an input tile is light, particularly white, and the information displayed on it is dark, particularly blue or black. However, it can also be the other way around, e.g., in a night mode of the display, in which the background is dark and the information is displayed in a lighter color. Preferably, there is sufficient contrast with the background to keep the information legible for the user under any normal lighting conditions, from darkness to sunlight. Preferably, the pipetting device has a light-sensitive photosensor. Preferably, the control device, in particular the data processing device, is configured for this purpose.The screen brightness is programmed to maintain a predefined relationship with the light intensity received by the photosensor. This can mean that the screen brightness increases when the ambient light intensity rises and decreases when the ambient light intensity falls. However, the screen brightness can also be constant, can be factory preset, can be automatically adjustable depending on other parameters—for example, depending on a loaded application scenario or user profile—and / or can be user-adjustable.

[0106] Preferably, the screen, particularly the home screen, has at least one input field, touching which allows the user to select at least one second pipetting parameter. Several advantageous solutions for this pipetting device have been found to implement these input options. In a first solution, the input field is a marked area at the edge of the screen, particularly the home screen, especially at the top or bottom edge, so as not to interrupt the list of input fields preferably displayed there. The special status of this input field compared to the input tiles displayed there clarifies its particular function, namely opening a new screen for selecting and / or deselecting new pipetting parameters (also called a "selection screen") to be added to (or removed from) the current parameter set.After closing the selection screen, the at least one selected pipetting parameter is added to the current parameter set and displayed on the screen. In a second solution for selecting / deselecting pipetting parameters, the screen has a size, in particular a length or width, that exceeds the display area available on the screen for showing the screen. Input tiles can be provided in this initially invisible area of ​​the screen, each containing a value or information describing the value of the pipetting parameter belonging to the input tile—for example, a switch indicating the "on / off" state of a specific pipetting parameter, and in particular the "on / off" state of the function represented by that pipetting parameter.

[0107] The screen page can be larger than the display area available on the screen for showing the screen page; in this case, the screen page can be scrollable, e.g., vertically scrollable. It can also be page-turning, whereby tapping a screen area or swiping the screen—based on the familiar "swipe" gesture—leads to scrolling through the screen content, i.e., to displaying the area of ​​the screen page that follows below, above, or to the side of the currently displayed area.

[0108] The term "selection" refers specifically to the activation of a pipetting parameter from a predefined set of pipetting parameters that may be stored in the data storage device of the pipetting instrument. Activating the pipetting parameter may immediately add it to the current parameter set, or it may be preceded by a confirmation dialog in which the user confirms or prevents this addition. Similarly, "de-selection" is defined as deactivating the selected pipetting parameter (and consequently modifying the user-defined parameter set).

[0109] Preferably, the data processing device is programmed to, after recording this user-selection of a pipetting parameter, in particular a second pipetting parameter, that

[0110] • the at least one - in particular second - pipetting parameter is added to the at least one first pipetting parameter of the parameter set, in particular a basic parameter set, in order to form with this at least one first pipetting parameter the pipetting parameters of a user parameter set that define a user-defined pipetting operation, and

[0111] • this selection of at least one second pipetting parameter is displayed to the user on the screen, especially the home screen.

[0112] Optionally and preferably, the data processing unit of the pipetting device is programmed to display a graphical user interface (GUI) on the screen, the GUI comprising at least the following: displaying a screen page, in particular a home screen, in which pipetting parameters of a parameter set of pipetting parameters are displayed, the screen page comprising at least one first input tile that displays the value of at least one first pipetting parameter of a parameter set, in particular a basic parameter set, that defines a pipetting operation, in particular a basic pipetting operation, and touching this tile opens an input interface that allows the user to input the value of the at least one first pipetting parameter, the screen page comprising at least one input field.the touching of which enables the user to select at least one second pipetting parameter, wherein the data processing device is programmed, after detecting this user-made selection, to add the at least one second pipetting parameter to the at least one first pipetting parameter of the parameter set, in particular the basic parameter set, in order to form with this at least one first pipetting parameter the pipetting parameters of a user parameter set that define a user-defined pipetting operation, and this selection of the at least one second pipetting parameter is displayed to the user on the screen, in particular the home screen.

[0113] The aforementioned features represent an advantageous aspect of the innovative operating concept of a pipetting device. User studies have shown the inventors that a significant portion of users can achieve a more efficient workflow with a pipetting device where they can define their desired pipetting processes according to their own preferences. This is done by supplementing an existing, for example, a proven or basic parameter set with additional pipetting parameters, i.e., functions or features. This approach clearly leads to the most efficient goal of defining a customized pipetting process. In particular, if a basic parameter set is displayed on a screen, especially a home screen, and is immediately accessible, a positive user experience is guaranteed without the need for lengthy study of operating instructions.Within a short learning curve, users can navigate the list of available pipetting parameters, thus more efficiently utilizing the extensive functionality of an electric pipetting device. This is particularly relevant for the large group of users who struggle to learn the existing—more or less complex—operating modes of conventional pipetting devices, which represent various application scenarios, and ultimately settle for the simplest modes. The innovative concept encourages inexperienced users to learn the functions while offering experienced users complete flexibility.

[0114] It should be noted that the aforementioned approach to defining a user parameter set does not preclude the possibility of offering other, particularly more complex, parameter sets for user selection—for example, via separate screen pages—which represent specific predefined application scenarios, are user-saved parameter sets, are automatically saved parameter sets from a list of previously used parameter sets (this list is also referred to as parameter set history), are the most frequently executed parameter sets statistically, or are a user-defined favorites list of parameter sets.

[0115] Such separate screen pages form part of the GUI, which, like preferably any other screen page, are displayed on the screen, in particular according to a program or program code stored in a data storage device, especially an operating program or control program. Examples of such screen pages, which are preferably part of the GUI, are the following: Preferably, a favorites screen page is provided in which one or more, optionally limited to a maximum total number M1, pipetting parameter sets are displayed, in particular listed, which were previously created by the user or loaded by the user from another screen page and marked as favorites by the user by means of an input option, e.g.by touching an input field, which may be provided in a menu and / or navigation bar, in particular one located at the edge of the screen, especially an input field with a star-shaped pictogram or a different appearance.

[0116] Preferably, a history screen page is provided in which one or more, optionally up to a maximum total number M2, of pipetting parameter sets are displayed, each of which is formed by a historical pipetting parameter set, in particular executed and in particular automatically saved in the past, which replicates a historical pipetting operation.

[0117] Preferably, a program set screen page is provided in which one or more pipetting parameter sets, optionally limited to a maximum total of M3, are displayed, in particular listed, which have been created by programming by the user. This programming can be carried out, in particular, on a programming screen page where the user, according to a modular system, step by step assembles program steps from predefined elements to define the sequence of a pipetting process definable by pipetting parameters. These inputs are automatically checked for consistency, in particular by the control program or another program, and the corresponding programmed pipetting parameter set is created and, in particular according to the user's specifications, added to the program set screen page, i.e., saved.Programming can also be performed on an external data processing device, in which case the externally generated, programmed pipetting parameter set is transferred to the pipetting device via a communication device. Programming is carried out, in particular, using a programming (macro) language implemented in the pipetting device, which a person skilled in the art can provide appropriately, especially through optionally selectable input fields, text descriptions, and pictograms in the GUI, which the user then assembles step by step. Preferably, however, the recorder function generates program (macro) code that can then be edited by the user, particularly on the programming screen.

[0118] Preferably, an auto-program set screen page is provided, displaying, and in particular listing, one or more pipetting parameter sets, optionally limited to a maximum total of M4. These sets were previously derived automatically, essentially without user intervention, by a recorder function of the pipetting device from user-defined and executed setting steps of pipetting parameters and / or pipetting operations, and then stored, in particular, in the data storage device. Typically, this recorder function is triggered by the user touching a GUI input field that defines the start of the recording function, and in particular, this recorder function is terminated by the user touching a GUI input field that defines the end of the recording function.To create the steps of a desired pipetting program, starting from a home screen with any desired pipetting parameters, the values ​​of these parameters are set, and the actuators are activated to perform the aspiration or dispensing of sample volumes as desired—simulated or not simulated. This means that the moving element, driven by the motor, can either preferably remain stationary or preferably move after the actuators are activated. This "teach-in" feature of the recorder function allows the corresponding pipetting parameter set to be created and saved while the pipette is being configured and the pipetting process is being performed, specifically without the user having to deal with a programming (macro) language implemented in the pipetting device.Preferably, the recorder function generates program (macro) code that can then be edited by the user, especially on the programming screen.

[0119] Preferably, a scenario screen page is provided in which one or more pipetting parameter sets, optionally limited to a maximum total of M5, are displayed, in particular listed, which are provided, in particular, by the manufacturer. These pipetting parameter sets can define one, several, or all of the application scenarios described above. The selection of the corresponding pipetting parameter set is made by touching the input field or tile that represents the corresponding application scenario and bears a corresponding short name.

[0120] Preferably, a mixed-function screen page is provided.

[0121] A pipetting parameter set on one of the aforementioned screen pages can be represented by an input field, in particular an input tile, which the user can tap to make the corresponding pipetting parameter set the current pipetting parameter set. The pipetting parameters of this set are then displayed on the (main) screen page—according to the patent claim—in particular the home screen, or on a separate screen page. Transferring the pipetting parameter set directly to the central screen page, in particular the home screen, is also referred to as quick selection. When transferred to a separate screen page, input options can be provided, in particular, to create a new program with the pipetting parameters of the selected pipetting parameter set, to edit the pipetting parameter set, and to delete it or parts thereof.

[0122] The total number M1, M2, M3, M4, M5 mentioned can in particular be selectable, or can be fixed, e.g. to any number between 1 and 50, in particular 2 to 30, in particular 5 to 25.

[0123] The basic parameter set can, in particular, comprise three pipetting parameters, specifically volume V, velocity v (a two-component, vector parameter: of aspiration / dispensing), and the number of repetitions n (of this aspiration or dispensing). The volume is, in particular, the volume to be aspirated into or dispensed from the pipetting container during a single aspiration and / or dispensing. Preferably, the input tile also displays information about the physical unit of the volume, e.g., mL or pL. The velocity is, in particular, a vector value that contains the two semantically related values—related to pipetting velocity—for the velocity of aspiration of the liquid into the sample container and the velocity of dispensing from the sample container.The numerical values ​​associated with the velocity can be proportional to the rate of fluid exchange between the pipetting container and the environment (alternatively: a non-proportional relationship). User-selectable velocities can be defined by velocity levels, which can be represented by ordinal numbers (e.g., 1...10), letters (A...J), or other symbols. Level 4 does not necessarily have to represent twice the velocity of level 2, but it can. A basic parameter set is chosen, in particular, to define an executable pipetting operation, as is the case in the example given (V,v,n).

[0124] Preferably, an input field is provided as an extra button, in particular only a single input field is provided, which is designed as an extra button and which in particular has a different shape and / or color and / or background color than the input tiles displayed on the screen, and / or is located at the edge of the screen. Touching the extra button preferably causes a selection screen to be displayed (instead of the screen, home screen, and as an overlay screen), in particular a predefined selection of available pipetting parameters, i.e., stored in a data storage device, in the form of a selection list, which contains information, in particular short descriptions (for identifying the content of the pipetting parameter), about selectable second pipetting parameters, from which the user can select the at least one second pipetting parameter.

[0125] Preferably, after the selection of at least one second pipetting parameter is completed, the selection screen or selection list is closed, and the screen page, in particular the home screen, is displayed again. This screen now displays not only the at least one first input tile but also at least one second input tile, which represents the selection and / or a value of the at least one second pipetting parameter or information about this at least one second pipetting parameter representing that value. The phrase "at least one first input tile" means, in particular, that, for example, exactly three "first input tiles" can be provided, so that the optionally added "at least one second input tile" can be the fourth of the four input tiles now displayed.

[0126] Preferably, it is provided that, in the case that the at least one second pipetting parameter can assume a user-selectable value, touching the at least one second input tile - within the selection screen / selection list or after closing the selection screen / selection list - opens an input interface that allows the user to enter the value of the at least one second pipetting parameter.

[0127] According to the second solution for selecting further pipetting parameters for the current parameter set, preferably a set N>=1 of input fields, in particular input tiles, is displayed on the screen, especially as a scrollable or paginable list of input tiles, wherein each input field is assigned and displayed information, in particular a short description, a pictogram, and / or a physical unit, about a second pipetting parameter selectable by means of the input field.

[0128] Preferably, after the user has selected at least one second pipetting parameter from the set N of input fields, the selection and / or a value or information representing this value of the at least one second pipetting parameter is displayed.

[0129] Preferably, it is provided that, in the event that the at least one second pipetting parameter can assume a user-selectable value, touching the at least one second input tile, which is now displayed in the screen / home screen, allows the user to enter the value of the at least one second pipetting parameter.

[0130] Preferably, the data processing device is programmed to display a screen page, in particular a home screen, on the screen, which includes at least one first input tile that displays the value of at least one first pipetting parameter and whose touch opens an input interface that allows the user to input the value of the at least one first pipetting parameter.

[0131] This input interface is preferably a screen area displaying a numeric keypad whose keys are individually touchable and can be used by the user to enter a sequence of digits defining the value of the first, or at least one, pipetting parameter. The screen area can also be the screen area of ​​a new screen page that replaces the current screen page. The input interface can also include a scrollable selection list, or another input such as an input wheel, of possible numerical values ​​or other information-entered selectable fields, or a parallel display of a plurality of possible selectable numerical values. Preferably, the input interface includes an input field in which the user confirms the previously made value change. Preferably, the input interface includes an input field in which the input or...The value setting is canceled and the user returns to the screen, in particular the home screen. Preferably, the input interface, preferably the screen, in particular the home screen, has an input field whose touch removes the last pipetting parameter added to the parameter set by selection, in particular the at least one second pipetting parameter, from the parameter set, or which undoes the last change made to the value of a pipetting parameter ("undo" function), or which resets the parameter selection to a default selection, in particular to a basic parameter set.

[0132] The input interface may in particular include a numeric keypad, at least one selection field for selecting from a list, in particular a pull-down menu, at least one picker wheel and other means to effect a change in the numerical value of a parameter, in particular a pipetting parameter, by touching the screen.

[0133] Preferably, the data processing device is programmed so that, if the value entered by a user via an input interface for a pipetting parameter is invalid, information is displayed on the screen and preferably

[0134] • at least one correction button is displayed, touching which automatically executes at least one correction process instead of the value entered by the user, which can have the following configurations:

[0135] Instead of the invalid value, a valid value is automatically set;

[0136] At least one alternative pipetting parameter to the aforementioned pipetting parameter is selected and, in particular, assigned the user's value or another suitable value;

[0137] The user's input is undone, and in particular, re-entry is enabled;

[0138] And / or

[0139] • An error message is displayed;

[0140] And / or

[0141] • The change to the previously current value is ignored and the previously current value is retained;

[0142] And / or

[0143] • Another non-combinable pipetting parameter that represents a non-combinable function will be automatically deselected.

[0144] Preferably, the data processing device is programmed to display a screen page, in particular a home screen, containing a list of essentially rectangular input tiles, which are arranged one below the other and extend substantially across the entire screen page. In this way, the available space is used optimally and operation is ergonomic.

[0145] Preferably, the data processing device is programmed to display a start screen (home screen) on the screen, which is in particular the screen displaying the pipetting parameters of a parameter set of pipetting parameters, and which is replaced by a second screen by a sideways or vertical swipe gesture, and which is replaced by a third screen by a sideways or vertically opposite swipe gesture. This does not preclude the possibility of displaying further screens by further swipe gestures starting from the second or third screen.

[0146] Preferably, the data processing device is programmed such that the second screen page has a list of input fields, each input field having a short name, and touching the input field loads a predetermined parameter set that defines a predetermined pipetting operation, wherein, in particular, after touching this input field, a screen page other than the start screen page is displayed, or, alternatively, the start screen page with the input tiles of the predetermined parameter set is displayed again.

[0147] Preferably, at least one screen is provided that offers the following special function of the pipetting device: The pipetting parameter of a target volume is required, which can be entered or changed via an input field. By continuously actuating an actuator, liquid is drawn into the pipetting container until the target volume is reached. Alternatively, or analogously, a special function for dispensing a target volume of liquid is optionally provided: By continuously actuating an actuator, liquid is dispensed from the pipetting container until the target volume is reached. This imitation of the operation of a conventional mechanical pipette grants the user a certain degree of additional control, for example, to briefly interrupt a pipetting process and, in particular, to pipette in a more controlled manner.

[0148] Preferably, the data processing device is programmed such that the third screen page has a list of input fields, each input field having a short label, and touching the input field loads one of the following parameter sets: a historical parameter set used in the past and automatically stored, which defines a historical pipetting operation;

[0149] Parameter sets that represent specific predefined application scenarios; parameter sets that are user-saved parameter sets;

[0150] Parameter sets that were statistically executed most frequently; parameter sets that belong to a user-defined favorites list of parameter sets;

[0151] Parameter sets created by user programming or automatically generated by a recorder function of the pipetting device—implemented by program code, which may in particular be part of the control program of the pipetting device—from individual setting steps manually configured by the user or executed pipetting operations; wherein, in particular, after touching this input field, a different screen page than the start screen page is displayed, or, alternatively, the start screen page with the input tiles of the predetermined parameter set is displayed again.

[0152] The screen (also referred to as "display") is a touch-sensitive screen (also referred to as a "touchscreen"). It is preferably a color display.

[0153] A touchscreen can serve as an input medium, a non-touch-sensitive screen can at least serve as an output medium for displaying information, or can serve as an input medium in combination with (a) control element(s) arranged next to the screen, especially if screen areas provide information about the function of the respective control element, which is then designed as a so-called soft key that can perform a variable function.

[0154] The screen is preferably essentially rectangular. By using essentially rectangular input tiles and / or rectangular information fields displayed on the screen, the screen area can be used optimally.

[0155] The screen is preferably substantially planar. This can improve readability, as the user can choose the least-reflective angle to light sources in a laboratory setting for operation, whereas with curved screens, light is captured from a wider angle and reflected into the user's eye. Preferably, a planar screen is flush with planar sections of the housing front in which the screen is mounted. This particularly facilitates touching near-edge areas of the touchscreen when it is protected all around by the housing front.

[0156] Preferably, according to a particularly advantageous embodiment of the operating concept, the data processing device is programmed to display a screen page, in particular an output screen page, which contains a separate input area, also referred to as a special button, the touching of which causes the output screen page to close and the input screen page or another screen page to be displayed on the screen. This other screen page can also allow, in particular, the editing of parameter values ​​contained in the pipetting parameter set. Touching the special button can also cause an interruption of an ongoing pipetting process, and it is possible that this interruption must be confirmed by the user via a security prompt.The completion of a pipetting operation also results in the screen reverting from the output screen to an input screen—without requiring the special button to be pressed. Information about the successful pipetting operation can be displayed before and after the output screen. The input screen to which one returns using the special button does not have to be exactly the previous input screen, for example, if one only needs to quickly adjust the speed after the pipetting sequence ("do") has already started. It may also be possible that, after a pipetting operation has begun, not all parameter values ​​can be changed / corrected, but only specific parameter values ​​of the current pipetting parameter set.

[0157] The distinction between the input mode ("set" or "set screen") represented by the input screen and the output mode ("do" or "do screen") defined by the output screen prevents, in particular, accidental changes to parameter values ​​while in "do" mode, which could potentially ruin laboratory work and result in a significant loss of value. On the other hand, switching from "set" to "do" mode by pressing the control element offers considerable user convenience and is intuitively understandable. This also contributes significantly to ergonomics and an efficient workflow.

[0158] The distinction between the input screen and the output screen can be made by one or more of the definitions listed below. The definition preferably relates to the state of the pipetting device in which the pipetting process has been started and the electrically controlled moving element is moving; however, the definition may not apply if the pipetting device is in the state in which the pipetting process has been started and the electrically controlled moving element is not moving.This allows, for example, in a multi-step pipetting process, an output screen to be displayed after a completed pipetting process or a completed sub-step of a multi-step pipetting process. This output screen allows the user to change one pipetting parameter from the parameter set, but preferably not all pipetting parameters from the parameter set that were changeable in the previously displayed input screen, particularly those that were changeable in the input screen displayed immediately before the start of the pipetting step. For example, it may be useful to allow the user to change one or more individual pipetting parameters in a multi-step pipetting process, especially those that do not critically affect the successful execution of the pipetting process.The aspiration and / or dispensing rate, also known as pipetting rate, can be a pipetting parameter whose modification does not necessarily alter the pipetting process itself and which can therefore be adjusted to user needs – either temporarily or between completed steps of the pipetting process. Possible definitions include:

[0159] Preferably, the output screen page, but not the input screen page, has the input field referred to as a special button, touching which causes the (output) screen page to close and the input screen page or another input screen page to be displayed on the screen.

[0160] If the output screen page has the special button, it is clear that the input screen page, especially the home screen, does not have the special button, since the special button is defined as closing the output screen page, which must therefore be currently displayed.

[0161] Preferably, the input screen page, but not the output screen page, has an input field called an extra button, touching which allows the user to change the number of pipetting parameters of the parameter set subsequently displayed on the input screen page.Preferably, the input screen page, but not the output screen page, has an input field designated as an extra button, the touching of which causes a selection screen to be displayed. This selection screen displays, in particular, a predefined set of available pipetting parameters, i.e., those stored in a data storage device, in the form of a selection list. This list contains information, in particular short descriptions (for identifying the content of the pipetting parameter), about selectable second pipetting parameters, from which the user can select at least one second pipetting parameter. "First pipetting parameters" are understood to be those that were already displayed on the input screen page, while "second pipetting parameters" are understood to be those that are added to the first pipetting parameters.

[0162] Preferably, the input screen page, but not the output screen page, has an input field that displays a pipetting parameter, in particular its numerical value, and touching this field immediately, i.e., in particular without significant delay and in particular without requiring any further user action, opens an input interface with which the user can change the value of the displayed pipetting parameter.

[0163] Preferably, the output screen and / or any subsequent output screen does not provide a means to change, in particular more than half, and in particular all, of the pipetting parameters previously displayed on the input screen and editable by input. Preferably, the output screen and / or any subsequent output screen does not provide a means to change the total number or a portion f (in particular: f > % or f > 2 / 3 or f > 1 / 2 or f > 1 / 3 or f > 1 / 4) or at least one of the pipetting parameters previously displayed on the input screen and editable by input.

[0164] Preferably, the output screen page and / or any subsequent output screen page displayed after the output screen page does not have any means, in particular no input field, to change at least one predetermined pipetting parameter previously displayed on the input screen page and modifiable by input, in particular to change it directly and / or indirectly. This at least one predetermined pipetting parameter is preferably selected from the following list of possible pipetting parameters:

[0165] {a volume to be aspirated or dispensed during the pipetting process; a number of sub-steps, in particular the total number, in a pipetting process comprising several sub-steps, in particular a number (greater than zero) of pre-wetting steps in a pipetting process, wherein during a pre-wetting step a liquid is aspirated into the pipetting container and dispensed again, in particular to wet the inner surface of a pipetting container before the start of the actual pipetting process; a time parameter, in particular a duration of a pipetting process or a sub-step of a multi-step pipetting process, or a latency time between pipetting processes or between sub-steps of a multi-step pipetting process;a parameter relating to the automatic execution / non-execution of a complete dispensing of any residual volume remaining in the pipetting container after the pipetting process has been carried out ("auto blow off" function activated or deactivated); a rate parameter relating to the rate of a pipetting process, in particular the rate of aspiration or dispensing of sample volume into / from the pipetting container, especially during partial steps of a multi-step pipetting process, in particular a dispensing process};

[0166] The pipetting volume can be a volume that is to be drawn into the pipetting container during the pipetting process or during a sub-step of a multi-step pipetting process, or it can be a volume that is to be dispensed from the pipetting container during the pipetting process or during a sub-step of a multi-step pipetting process, in particular the dispensing volume to be dispensed during a multi-step dispensing process.

[0167] Preferably, the output screen page or a subsequently displayed output screen page, in particular apart from the special button, does not have an input field, in particular no input field whose touching results in a change, in particular an immediate change, to the content of the output screen page and / or a change, in particular an immediate change, to the started pipetting process.

[0168] Preferably, the output screen page or a subsequently displayed output screen page, in particular apart from the special button, does not have an input field for changing any of the pipetting parameters that were displayed in the previously displayed input screen page and could be changed there by input.

[0169] Preferably, the output screen or a subsequently displayed output screen, apart from the special button, does not have an input field for changing a pipetting parameter, the touching of which, in particular directly or indirectly, enables the modification of one or more or all of the pipetting parameters of the parameter set of pipetting parameters entered via the input screen, in particular to change at least one previously displayed and editable predetermined pipetting parameter on the input screen, and / or in particular to change one of the pipetting parameters of an ongoing pipetting operation. "Change directly" means in particular that an input interface opens immediately after touching the input field, in which the user can change the value of the displayed pipetting parameter.“Indirectly changing” means, in particular, that an input screen page with at least one input field opens first, touching which immediately opens an input interface in which the user can change the value of the displayed pipetting parameter.

[0170] Preferably, only on the input screen page, particularly on the home screen, is the modification of at least one, several, or all of the modifiable pipetting parameters of a parameter set of pipetting parameters provided, but not on the output screen page. In particular, only an input screen page, but not the output screen page, includes an input field, in particular at least one first input tile, which displays the value of at least one first pipetting parameter of a parameter set, in particular a basic parameter set, that defines a pipetting operation, in particular a basic pipetting operation, and whose touch—that is, without any further user input following this touch—opens an input interface that allows the user to enter the value of the at least one first pipetting parameter.These pipetting parameters of the parameter set of pipetting parameters may in particular be selected from the above list of possible “predetermined operating parameters”.

[0171] Preferably, the output screen, but not the input screen, displays different content, preferably depending on the current sub-step of an automated multi-step pipetting process, in particular the values ​​of the pipetting parameters defining the currently running sub-step, e.g., the dispensing of a partial volume Vt at a specific dispensing rate v2, as sub-step i of a total of N steps of the pipetting process. This can be the case, for example, in the application scenario "Dis".

[0172] Preferably, the output screen page, but not the input screen page, displays a progress indicator, preferably depending on the current sub-step of an automated multi-step pipetting process, which contains information about the progress of the multi-step pipetting process.

[0173] Preferably, the output screen page, but not the input screen page, displays a variable display element, in particular a display wheel or a display roller, preferably depending on the current sub-step of an automated multi-step pipetting process, as will be explained below.

[0174] The above definitions, in particular, allow for the differentiation between the input screen and the output screen. Starting a pipetting process can be subject to different start conditions or be predefined. It can occur directly by (first) pressing an actuating element, or, for security reasons or other reasons, it can be initiated by a second actuating immediately following this first actuating (i.e., without touching the special button), and optionally by a third actuating element that is different from the touchscreen. The data processing device is preferably programmed to display the input screen, in particular the home screen, for the display and input of pipetting parameters from a parameter set of pipetting parameters, andWhen the actuation of at least one (different from the screen) control element is detected, the screen should display an output screen page (abbreviated: "do") instead of the input screen page, for displaying pipetting parameters of the parameter set defined in the input screen page. In particular, triggered by this actuation or by a subsequent actuation of one of the (different from the screen) control elements, the pipetting process should be started. Specifically, when the actuation of the at least one control element that causes the display of the output screen page is detected, or by a subsequent actuation of one of these control elements, the pipetting process defined according to this pipetting parameter set should be started. The data processing device is preferably programmed to...that the aforementioned starting conditions can be selected by the user at the pipetting device via an input interface of the GUI.

[0175] The input screen preferably differs from the output screen, particularly in its graphical representation; in particular, the output screen has a different color scheme and / or a different arrangement of markers and / or information fields. Specifically, the output screen will display different content, preferably depending on the current sub-step of an automated multi-step pipetting process, especially the values ​​of the pipetting parameters currently defining the sub-step, e.g., the dispensing of a partial volume Vt at a specific dispensing rate v2 as sub-step i of a total of N steps in the pipetting process. This can be the case, for example, in the application scenario "Dis".The concept of distinguishing between an input screen and an output screen, implemented primarily through visual differentiation, offers a significant ergonomic advantage in operation, as the user can easily recognize whether they are currently in a pipetting process—possibly interrupted and awaiting input—or in a settings mode. The input and output screen concept thus implies such input and output modes for the pipetting device, which are easily distinguishable for the user. Preferably, only touching the separate input area—or a completed pipetting process, which can automatically return to an input screen, particularly the home screen—allows the user to change parameter values ​​or select parameters again.This separation prevents, in particular, accidental changes to parameter values ​​while the "do" mode is running, which could potentially ruin laboratory work and result in a significant loss of value. On the other hand, switching from "set" to "do" mode by pressing the actuator offers considerable user convenience and is intuitively understandable. This also contributes significantly to ergonomics and an efficient workflow.

[0176] The at least one actuating element is not, in particular, part of the touchscreen. The at least one actuating element is preferably designed as a push button, specifically as a user-activated component, which can be actuated, in particular, with the thumb when the user holds the handheld pipetting device in the intended manner with one hand, by grasping the housing, which serves in particular as a handle, and in particular by resting a hand support of the housing on an index finger. The touchscreen is operated, in particular, by a finger of the hand that is not holding the pipetting device.

[0177] The data processing device may be programmed so that activating a drop button (to drop a pipette tip) of the pipetting device while displaying an output screen page, especially in the output mode of the pipetting device, in some scenarios or generally results in the input screen page, especially the home screen, or another input screen page being displayed instead of the output screen page and / or the pipetting process being stopped or aborted.

[0178] A pipetting program defined by the pipetting parameters of a parameter set can have several phases, for example, if certain step sequences or sub-steps are repeated repetitively or cyclically. If a pipetting operation involves, for example, 10 step sequences, then the output screen preferably displays, for each executed step, which of the 10 step sequences is currently being executed and / or how many step sequences remain. Additionally, the pipetting parameter(s) of the current (active) step can be displayed. The output screen preferably displays the active parameter settings so that it is clear what will happen next when the actuator is pressed, e.g., pipetting step 3 of 3 with 150 pL and speed X.

[0179] Preferably, the output screen displays various content, preferably depending on the current sub-step of an automated multi-step pipetting process, in particular the values ​​of the pipetting parameters defining the currently running sub-step, e.g., the dispensing of a partial volume Vt at a specific dispensing rate v2, as sub-step i of a total of N steps of the pipetting process. This can be the case, for example, in the application scenario "Dis".

[0180] To indicate the progress of the multi-step pipetting process, the output screen preferably includes a display element, in particular a single- or multi-part output tile. The display element shows various content, preferably depending on the currently running sub-step of an automated multi-step pipetting process, in particular the values ​​of the pipetting parameters that define the currently running sub-step. The display element occupies a resizable or constant area of ​​the output screen.

[0181] Preferably, the first view of the display element in a first state, in which it displays substep i (i is a counter index that counts the substeps, particularly those that occur sequentially), differs from a second view in a second state in that it displays substep i+1. The difference in the view can consist of the fact that in the first state a counter index i and in the second state a counter index i+1 are displayed on the output screen, particularly in the display element. Furthermore, the difference in the view can consist of the fact that different values ​​of pipetting parameters used in the respective substep are displayed on the output screen, particularly in the display element, in the first and second states.

[0182] Preferably, the display element has a first output tile showing one or more values ​​of one or more pipetting parameters used in the currently running sub-step i. Preferably, the display element also has a second output tile showing one or more values ​​of one or more pipetting parameters used in the subsequent sub-step i+1. This gives the user a better overview and control over the operation of the pipetting device. Preferably, the display element has another second output tile or a third output tile showing one or more values ​​of one or more pipetting parameters used in the preceding sub-step i-1. This also gives the user a better overview and control over the operation of the pipetting device.Similarly, further output tiles with successively planned future sub-steps (e.g., i+2, i+3, etc., until i=N) can be displayed at least partially and simultaneously. Similarly, further output tiles with successively past sub-steps (e.g., i-2, i-3, etc., until i=0) can be displayed at least partially and simultaneously.

[0183] Depending in particular on substep i, the display element can include the first output tile and one or more of the second and / or third output tiles.

[0184] Preferably, the display element has, at least during a sub-step i, the aforementioned first output tile, the aforementioned second output tile, and the aforementioned third output tile. Preferably, the first output tile is spatially arranged between the second and third output tiles. In this arrangement, the display element is also referred to as a display wheel or display roller. The display roller preferably has at least three positions (e.g., center, left, right; or: center, top, bottom) that can be occupied by output tiles characterizing a respective sub-step. The progression of the multi-step pipetting process, counted by the index counter i, is illustrated by a rotation of the output tiles of the display roller, since, for example, in a ten-step (N=10) pipetting process (e.g.,At the beginning of the pipetting process (i=1), the output tile corresponding to sub-step i=1 is in the center roller position, while an output tile corresponding to sub-step i=0 either does not exist; or exists and is displayed to the side (left, right, top, bottom) of the center position, showing information about the entire pipetting process, other information, or no information at all; and the output tile corresponding to the future sub-step i=2 is positioned to the side of the center roller position and opposite the first position (e.g., right, left, bottom, top). After completion of sub-step i=1, the first output tile moves from the center position to a side position, and the second output tile relating to the now-running sub-step i=2 moves to the center position, while the third output tile relating to the now-future sub-step i=3 is newly displayed in the other side position of the display roller.

[0185] Preferably, a progress indicator is displayed on the output screen, particularly in the display element, and especially in at least one output tile of the display element, containing information about the progress of the multi-step pipetting process. In particular, the counter index i and additionally the value N of the total number of sub-steps of the multi-step pipetting process can be displayed, for example, in the form of a text output "i of N" or "i / N". The progress indicator can additionally or alternatively include a non-numeric and graphical representation of the progress, in particular a progress bar, or a line representing the successively executed sub-steps 1...N with the position of the currently running sub-step i graphically highlighted.

[0186] If a display element has multiple output tiles depending on the step, as is the case with a display roller, the transition from the first view to a second view of the display element can be animated. Furthermore, the lateral positions of a display roller can be shaded or highlighted, particularly to simulate or represent a three-dimensional object (roller, wheel), and / or to simulate or represent perspective. This makes working with the pipetting device even more intuitive.

[0187] Preferably, the data processing device is programmed to provide a pipetting device with exactly one first and one second actuating element, which can be actuated separately, in particular by means of a rocker switch. Separately, a eject button can be provided for ejecting a pipetting container, in particular a pipette tip. This makes operation intuitive and ergonomic.

[0188] The data processing device is preferably programmed to detect the actuation of an actuator, in particular the first actuator, by the user and, depending on the actuation of the actuator, to start the pipetting process defined according to the parameter set. It is possible that the pipetting process starts immediately after the actuation of the actuator, or that one or two intermediate steps occur before the start, e.g., a blow-out, i.e., the expulsion of residual liquid in a pipetting container by means of over-stroke, or pre-wetting of the pipette tip by aspiration and dispensing of a pre-wetting volume of the sample one or more times before the start of the subsequent steps of the pipetting process, or a mixing step can take place, which involves aspiration and dispensing of a mixture volume before the start of the subsequent steps of the pipetting process.

[0189] Preferably, the pipetting device has a first and a second actuating element, each of which is a separately arranged button. Preferably, the pipetting device has a rocker switch and a first and a second actuating element that can be actuated separately by the rocker switch, whereby pressing a first pressure surface of the rocker switch actuates the first actuating element and pressing a second pressure surface of the rocker switch actuates the second actuating element, wherein the first and the second pressure surfaces are haptically distinguishable.In particular, the first and second pressure surfaces can be distinguished with respect to the following haptically perceptible and distinguishable external features: * the direction of the optional curvature of the first and second pressure surfaces, in particular by the first pressure surface being concave and the second pressure surface being convex; * the surface structures of the first and second pressure surfaces; * the materials of the first and second pressure surfaces. In predetermined situations during the operation of the pipetting device, e.g., after starting an execution mode by pressing one of the actuating elements in the setting mode, the first actuating element can, in particular, cause the sample to be aspirated, and the second actuating element can, in particular, cause the sample to be dispensed. Alternatively, the second actuating element can, in particular, cause the sample to be aspirated, and the first actuating element can, in particular, cause the sample to be dispensed.

[0190] Preferably, the pipetting device has a housing configured as a handle for the user to hold the pipetting device with a single hand, and which includes an axial section containing the piston, along whose longitudinal axis A the piston extends, and wherein the pipetting device has a first and a second actuating element, which can be actuated separately by a rocker switch mounted on a platform surface of the pipetting device, in particular a thumb rest surface, which is arranged at an angle of 80° < a < 180° to the longitudinal axis and which preferably slopes downwards. The direction "downwards" denotes the direction of gravity when the longitudinal axis of the pipetting device is arranged parallel to gravity.The plateau surface is arranged in such a way that the user's thumb rests on the thumb support surface in a virtually fatigue-free manner when holding the pipetting device with one hand (the "sweet spot" of the grasping hand).

[0191] Preferably, the pipetting device has a housing that is made of or contains plastic.

[0192] Preferably, the plateau surface is perpendicular to a plane that passes through the longitudinal axis and perpendicular to a surface of the screen.

[0193] Preferably, the pipetting device has a housing with an axial section containing the moving element, in particular a piston or piston rod, along the longitudinal axis of which the moving element extends, and a head section having a front surface inclined to the longitudinal axis, which is formed by the surface of the screen and preferably a frame surrounding it, wherein the screen occupies at least 70%, preferably at least 80% or even at least 90% of the front surface; and wherein, in particular, a frame front surface lies in a first plane and the screen lies in a second plane which is identical to or parallel to the first plane.

[0194] Preferably, the pipetting device comprises a housing with a connecting section for at least one pipetting container and with a release button, the contact surface of which can be moved along a certain distance into the housing by pressing the release button. The pipetting device is configured such that, upon reaching the end of this distance, the at least one pipetting container, in particular the pipette tip, is ejected, or an electrical signal is generated that triggers the ejection of the at least one pipetting container, in particular the pipette tip. The release button may be spring-loaded. Ejection may also be purely mechanical, with the energy required for ejection being supplied by the user, either directly during ejection or indirectly by tensioning a spring element when placing the pipette tip on the device.

[0195] The invention also relates to a system for inputting pipetting parameters, in particular mixing parameters, comprising the handheld pipetting device according to the invention, and an external data processing device, in particular a smartphone or tablet PC, which has an external screen, i.e., a screen that is not part of the pipetting device, and a data processing unit programmed to display an external input screen page ("set") for displaying and inputting the pipetting parameters of a parameter set of pipetting parameters and / or to display a mixing function screen page, wherein the external input screen page and the input screen page of the pipetting device are essentially identical in content, i.e.,We have the same functionality on the screen page, in particular the input screen page of the pipetting device, wherein the system is set up to transfer the pipetting parameters defined on the external data processing device to the pipetting device and use them there to define a pipetting operation, and / or to transfer the pipetting parameters defined on the pipetting device to the external data processing device and store them there.

[0196] The pipetting device or an external data processing device preferably includes a data storage device. This preferably includes at least one data storage device, in particular a hardware data storage device, especially a non-volatile data storage device, in particular an EPROM or FLASH memory. It may also include a volatile data storage device.

[0197] The electrical control unit of the pipetting device or an external data processing device, also referred to as the control unit or control device, preferably comprises a data processing unit, which in particular includes at least one central processing unit (CPU). The data processing unit may include a microcontroller. The control unit preferably includes a microcontroller. The control unit preferably includes at least one storage device or data storage unit for storing data, in particular pipetting parameters and / or one or more computer programs or computer program code.

[0198] The control unit preferably includes at least one control software or control program which uses at least one pipetting parameter to automatically execute at least one function of the pipetting process, a part of the pipetting process, or the entire pipetting process. The control software or control program is executed, in particular, by the data processing unit of the control unit, specifically by a CPU of the data processing unit. The control software or control program is stored, in particular, in a data storage device of the device. This data storage device is preferably non-volatile memory.

[0199] The pipetting device or an external data processing device may include a sensor, e.g., a sensor for detecting an environmental parameter, in particular temperature, humidity, or pressure, or the motor current used for the piston drive of the pipetting device. The motor current can be used, in particular, to determine the viscosity of the pipetted liquid and thus to identify the liquid. The sensor may also be configured to perform a measurement with which a parameter, in particular a pipetting parameter, specifically the type of pipetting container connected to the pipetting device, and in particular the maximum filling volume of the pipetting container, especially of a pipette tip, can be determined.The pipetting device or an external data processing device can be configured to automatically determine at least one pipetting parameter based on the measured value from the sensor device. This allows for improved optimization of the pipetting parameters required for precise pipetting.

[0200] The pipetting device and / or an external data processing device is preferably operated independently of the mains power supply. In particular, the respective device may be equipped with a rechargeable power source, for example, one or more batteries. In this case, the device may have a charging interface connected to the rechargeable power source.

[0201] Pipette tips are primarily disposable products and are preferably made of plastic. Different pipette tips are used with piston-stroke pipettes depending on the required maximum liquid volume. Typical nominal volumes of commercially available pipette tips are, for example, 10 pL, 20 pL, 100 pL, 200 pL, 300 pL, 1000 pL, 1250 pL, 2500 pL, 5 mL, and 10 mL (pL: microliter; mL: milliliter). A pipette tip generally has an elongated, conical container along a longitudinal axis, featuring a liquid exchange port at its lower end and a conical, tubular, upward-opening end section at its upper end. This end section can be attached to a connecting section, designed as a working cone, of the air-cushion pipette.The liquid is drawn into the pipette tip by means of a vacuum inside the tip. In the case of an air-cushion pipette, this vacuum is created by the movement of the piston-like moving element of the pipette, generating a vacuum in the air space above the sample in the pipette tip. In the pipetting position, also known as the insertion position, where the pipette tip is connected to the connecting section of the piston-stroke pipette, the interior of the pipette tip is fluidically connected to the pipetting channel of the piston-stroke pipette. This channel is pressurized by a cylinder piston within a hollow cylindrical piston chamber, which is electrically movable.

[0202] A dispenser tip is used in positive displacement pipetting systems where there is essentially no air cushion between the piston and the liquid sample during pipetting. The piston is an integral part of the dispenser tip. This tip comprises a container section, functioning as a piston cylinder, with a container opening and a container port into which the piston engages. The piston is slidably positioned within the piston cylinder and, in its end position, is able to displace the entire aspirated liquid contents. When connecting the dispenser tip to the positive displacement pipetting device, the container section is attached to the connecting section of the pipetting device, typically by screwing it on, and the piston is coupled to the moving element via a coupling device. Dispenser tips are primarily disposable products and are preferably made of plastic.Depending on the required maximum liquid volume, different dispenser tips are used with the positive displacement pump. Typical nominal volumes of commercially available dispenser tips are, for example, 100 pL, 200 pL, 500 pL, 1 mL, 2.5 mL, 5 mL, 10 mL, 25 mL, and 50 mL. The invention relates to a handheld pipetting device, a data processing device interacting with it, a system, and a computer program or computer program code, which may be stored, in particular, on a data storage medium. The possible and preferred embodiments of each of these items result from the description of all embodiments of the other items; in particular, possible embodiments of the handheld piston-stroke pipette result from the description of the method, the (especially external) data processing device, the system, and the computer program.

[0203] Further preferred embodiments of the method according to the invention, the handheld pipetting device, the data processing device interacting with it, the system, and the computer program will become apparent from the following description of the exemplary embodiments in conjunction with the figures and their description. Identical components of the exemplary embodiments are essentially identified by the same reference numerals, unless otherwise described or evident from the context. The figures show:

[0204] Fig. 1a shows a schematic side view of an embodiment of a pipetting device according to the invention, here an air cushion pipette.

[0205] Fig. 1b shows a detail of the rocker switch of the pipetting device from Fig. 1a.

[0206] Fig. 1c shows a view of the pipetting device from Fig. 1a, rotated slightly about the longitudinal axis A.

[0207] Fig. 1d shows a perspective side view of a detail of the pipetting device from Fig. 1a, with a visible touchscreen.

[0208] Fig. 1e schematically shows a system according to the invention in an exemplary embodiment. Fig. 2a shows, based on two images of the head area of ​​the pipetting device from Fig. 1a in an exemplary embodiment, the functionality of the GUI of the pipetting device to switch between two main types of screen pages, namely between an input screen page and an output screen page.

[0209] Fig. 2b shows input screen pages of the GUI and below them (symbolically) an actuating element of the pipetting device starting from an input screen page ("set"), which is replaced by an output screen page by actuating the actuating element, which - or rather its content - changes successively in the dispensing pipetting process ("Dis") shown here.

[0210] Fig. 2c shows an input screen page of the GUI, with a short name list of the currently selected pipetting parameters for the pipetting parameter set, the short name list being implemented in the form of “tags” arranged at the top of the screen, each showing a short name of the selected pipetting parameters; this allows the user to keep track of the already selected pipetting parameters, even if they do not see the entire (scrollable) selection list.

[0211] Fig 2d shows an input screen page, in particular the home screen, of the GUI and a parameter selection screen page that is overlaid on the input screen page when a separate input field on the input screen page is touched.

[0212] Fig 2e shows an output screen page of the pipetting device according to the invention in an exemplary embodiment, during a multi-step dispensing process, in a first state in sub-step i=2 and a second state in sub-step i=3.

[0213] Fig. 2f shows an output screen page of the pipetting device according to the invention, as shown in an exemplary embodiment, during a multi-step pipetting process. Fig. 2g shows an image of the head area of ​​a pipetting device according to the invention, in which a mixing function screen page is displayed, which occurs in a mixing function mode of the pipetting device according to an exemplary embodiment of the invention.

[0214] Fig. 3a shows, using two images of the head area of ​​a pipetting device according to the invention as an exemplary embodiment, further functionalities of the GUI of the pipetting device, namely, starting from a home screen, adding further pipetting parameters or functions to the current parameter set via a selection list in the selection screen.

[0215] Fig. 3b shows, using two images of a pipetting device according to the invention as an exemplary embodiment, further functionalities of the GUI of the pipetting device, namely, starting from a home screen with scrollable content or a scrollable selection list, adding further pipetting parameters or functions to the current parameter set.

[0216] Fig. 4 shows, using several images of the screen of a pipetting device according to the invention as an exemplary embodiment, the functionality of the GUI of the pipetting device to switch between the display of different screen pages.

[0217] Fig. 5a shows, using several images of the screen of a pipetting device according to the invention as an exemplary embodiment, the functionality of the GUI of the pipetting device, to set pipetting parameter values ​​by means of an input mask.

[0218] Fig. 5b shows, using two images of the screen of a pipetting device according to the invention as an exemplary embodiment, the functionality of the GUI of the pipetting device, namely to call up a historical list of pipetting parameters or to use an optional menu bar with input fields or, as a navigation aid, information fields not serving as input fields for the input screen page. Fig. 6 shows, using several images of the screen of a pipetting device according to the invention as an exemplary embodiment, the functionality of the GUI of the pipetting device, namely to select predetermined parameter sets representing specific application scenarios.

[0219] Fig. 7a shows, using two images of the screen of a pipetting device according to the invention as an exemplary embodiment, the functionality of the GUI of the pipetting device, to mark a current parameter set as a favorite, which is then saved as a favorite and in particular is displayed in a favorites screen page as a selectable list entry, namely as a correspondingly informative input tile.

[0220] Fig. 7b shows, using two images of the screen of a pipetting device according to the invention as an exemplary embodiment, the functionality of the GUI of the pipetting device, that the input tile characterizing a favorite parameter set in the favorites screen page has an input field, touching which transfers the parameters of the favorite parameter set to a separate screen, which is then displayed, in which the parameter values ​​and / or the parameter selection of the favorite parameter set can be changed.

[0221] Fig. 1a shows the handheld pipetting device according to the invention for pipetting at least one liquid sample, here an air cushion pipette 1. This device comprises: a connecting section 2 for connecting at least one pipetting container 19, here a pipette tip, with a movement element electrically controlled by the control unit 5, here the piston 3, for aspirating the at least one sample into the at least one pipetting container 19, holding the sample in the at least one pipetting container and dispensing the sample from the at least one pipetting container during a pipetting process; with a touch-sensitive screen 4 on the front surface 14a of the head section 14 of the pipetting device, for inputting the parameter values ​​of user-definable pipetting parameters, wherein a parameter set of pipetting parameters completely defines the pipetting process.wherein the electrical control unit 5 comprises a data processing unit 6, which is programmed to control the movement element 3 depending on the at least one pipetting parameter, as well as a data storage unit 7 and a communication unit 8 for wireless communication with an external data processing device, with exactly two operating elements (synonymous: actuating elements) 9a and 9b, which can be actuated by the user by means of an operating rocker switch 10. Each of these actuating elements can, by its actuation, switch the pipetting device from an input mode (“set”), in which an input screen page 100, 100’ is displayed on the screen, e.g. the home screen shown in Fig. 1d, to an output mode (“do”), in which an output screen page is displayed on the screen. This advantageous aspect of the operating concept is further illustrated by reference to Figures 2a,Figures 2b and 4 are also explained. Actuating the eject button 15 and a (not shown) "power on / off" button of the pipetting device does not, however, switch between "set" and "do" modes. The list of pipetting parameters belonging to the parameter set can be edited using the input field 101', marked with a "+" sign in Figure 1d and also referred to as the "extra button". In the mixed function mode (see Figure 2g), the actuating element 9b serves as the mixed function input element.

[0222] The operating rocker has a lower section 10b, which is concave and whose actuation activates button 9b, in particular causing sample dispensing, and an upper section 10a, which is convex and whose actuation activates button 9a, in particular causing sample aspiration. The operating rocker sits on a plateau formed by a housing section, which forms an angle of approximately α = 130–140° with the longitudinal axis A of the pipetting device. Due to the hand rest 16 arranged perpendicular to the longitudinal axis next to the plateau, the pipetting device is ergonomically positioned in the hand, and the thumb can rest comfortably on the rocker 10, as the hand position allows the thumb to rest on a "sweet spot" of the hand. The screen 4 is arranged in a head-housing section 14 of the pipetting device.

[0223] In the mixed function mode (see Fig. 2g) the actuating element 9a or the rocker half 10a serves as the mixed function input element.

[0224] The pipetting device has an electric motor 18, which is powered by a battery 17 and moves the piston rod or piston 3 (moving element) within the cylinder piston 12, resulting in an intake or discharge pressure in the pipetting channel 13. Precise dosing is possible thanks to the electronic control. A discharge button 15 is provided, which allows the pipette tip 19 to be ejected from the connecting section 2 by means of a discharge sleeve of the pipetting device. The data processing unit is specifically programmed to terminate any ongoing pipetting process when the discharge button 15 is activated and to replace any output screen page still displayed with an input screen page 100.

[0225] By actuating either of the two actuating elements 9a, 9b, the user would start the pipetting process defined according to the current parameter set. The selection of the pipetting parameters from a parameter set that defines the desired semi-automated pipetting process, and the setting of the values ​​of these pipetting parameters, is carried out using a GUI that implements the special operating concept according to the invention. This operating concept is explained with reference to the following figures.

[0226] The data processing unit 6 is programmed (see Fig. 2a) to display an input screen page 100, 100' ("set", see contents of the rectangle enclosed by the dashed line) in the screen 4 for displaying and entering pipetting parameters of a parameter set of pipetting parameters, and, when an actuation of at least one of the actuating elements 9a or 9b is detected, to display an output screen page 200 ("do") in the screen 4 for displaying pipetting parameters of the parameter set defined in the input screen page, and furthermore, when this actuation of the at least one actuating element is detected or upon subsequent actuation (in the sense of an optional safety prompt) of one of these actuating elements, to start the pipetting operation defined according to this pipetting parameter set, whereby the output screen page 200, or another output screen page displayed after the output screen page 200,The screen features an input area, implemented as a special button 201 (labeled here with the information "back"), located at the bottom of the screen. Touching this area closes the output screen page 200 and displays the input screen page 100, or another screen page, particularly the input screen page, on screen 4. Specifically, a subsequent second touch of one of the (screen-distinct) actuation elements 9a, 9b starts the pipetting process defined according to the current pipetting parameter set.

[0227] The aforementioned alternative screen can, in particular, allow editing of parameter values ​​contained in the pipetting parameter set. It does not have to be exactly the preceding input screen 100 if, for example, the speed only needs to be quickly adjusted once the pipetting sequence ("do") has already started. It may also be possible that, after the pipetting process has begun, not all parameter values ​​can be changed / corrected, but only specific parameter values ​​of the current pipetting parameter set.

[0228] Input screen page 100 and output screen page 200 differ in their graphical and / or textual or numerical representation, particularly in their color scheme: the input fields on input screen page 100 mostly display black information (letters, numerical values, input field color) on a light or white background, while the display fields on output screen page 200 mostly display blue information on a light or white background. The black input field 101 (also referred to as the extra button) of the input screen, which opens the selection screen for choosing pipetting parameters, does not exist on the output screen page.

[0229] In particular, the output screen page 200 will display various contents, preferably depending on the currently occurring sub-step of an automated multi-step pipetting process, especially the values ​​of the pipetting parameters currently defining the sub-step, e.g., the dispensing of a partial volume Vt at a specific dispensing rate v2 as sub-step i of a total of N steps of the pipetting process. This can be the case, for example, in the application scenario "Dis", which is shown in Fig. 2b.

[0230] In Fig. 2b, an input screen page 100_1 is initially displayed, containing the pipetting parameter set for a semi-automated dispensing process. The extra button 101_1, which is graphically slightly modified compared to the extra button 101, allows the pipetting parameter list to be edited analogously. Actuation of the actuating element, namely switch 9a or the first pressure surface 10a of the rocker switch 10, moves the pipetting device from "set" mode to "do" mode. The output screen page 200_1 is then displayed, containing the special button 201_1, which is graphically modified compared to the special button 201 but otherwise functions analogously. After an aspiration process has been performed, e.g.,After a period of 2 seconds, during which the step of aspirating 360 pl of solution into the pipetting container is performed, the output screen corresponding to the step of dispensing the first dispensing volume of 120 pl is displayed on output screen page 200_1. Pressing the actuating element, in this case the second pressure surface 10b of the rocker switch 10, initiates the dispensing of the volume; each subsequent press of pressure surface 10b leads to the next dispensing step. The dispensing steps are numbered by an index counter i=1 ...3, and the progress indicator i / N (i=1 ...3; N=3) displays the progress of the semi-automatic dispensing process in an output field on the output screen page. To make the progress even more intuitive for the user, a variable display element can be used, e.g., the indicator roller shown in Figures 2e and 2f.The output screen page 200_1 does not have such a variable display element; the output tiles are always in the same position on the output screen page 200_1, only the numerical display of the parameter values ​​and the progress indicator change.

[0231] Fig. 2e shows an output screen 200' of the pipetting device according to the invention, in an exemplary embodiment, during a multi-step dispensing process, in a first state in sub-step i=2 (left side of the figure) and a second state in sub-step i=3 (right side of the figure). The output screen has a variable display element 203', which is designed as a display roller. In a variable display element that has at least one output tile, the position of at least one output tile within the display element changes. The display roller 203' has a central output tile 203a', which displays the pipetting parameter "partial dispensing volume" with the value 200 pl of an (N=6)-step dispensing process, the dispensing rate "8", and a numerical progress indicator ("2 / 6").Above the middle output tile 203a', the upper output tile 203b' is displayed, showing "Dispense 200pl" of the preceding dispensing sub-step (i=1). Below the middle output tile 203a', the lower output tile 203c' is displayed, showing "Dispense 200pl" of the dispensing sub-step (i=3) immediately following the current sub-step i=2. On the right side of the image, the same output screen page 200' is shown, which will be displayed during the next dispensing sub-step with i=3. Above the middle output tile 203a', the upper output tile 203b' is displayed, which shows "Dispense 200pl" of the preceding dispensing sub-step (i=2), and below the middle output tile 203a', the lower output tile 203c' is displayed, which shows "Dispense 200pl" of the dispensing sub-step (i=4) immediately following the current sub-step i=3.The transition of the display element 203' from i=2 to i=3 (left to right) can be animated to illustrate the dynamics of the progress. The variable display element makes the perception of the multi-stage pipetting process and the operation of the pipetting device more intuitive. In the case of the last partial dispensing step (i=N; here i=6), the lower position 203c' of the display roller either shows information about reaching the end, displays other information, shows nothing, or the corresponding output tile 203c' is not displayed at all. A similar approach can be implemented for the upper output tile 203b' in the first partial dispensing step i=1, which might then, for example, show nothing or be omitted.

[0232] The display roller has a horizontal axis of rotation, while the output tiles change position vertically. Alternatively, a vertical or inclined axis of rotation would be possible.

[0233] Fig. 2f shows an output screen page 200" of the pipetting device according to the invention, in an exemplary embodiment, during a multi-step (M=32) pipetting process, in a state at sub-step i=8. Here, too, a display roller 203" is shown, which has the middle output position or output tile 203a", the upper output tile 203b", and the lower output tile 203c", which function analogously to the display roller 203'. Additionally, the output screen page 200" has further functionality, which is achieved by means of further output fields and input fields. Preferably, an output screen page does not have an input field that displays the value of a pipetting parameter and whose touching would allow the changing of a pipetting parameter in the next step, as is implemented in the present exemplary embodiments.In "Do" mode, which is active while displaying an output screen page, changing pipetting parameters is not possible, or only possible via intermediate steps, and not all pipetting parameters in the parameter set are modifiable. For example, it may be possible to change the rate of dispensing / receiving the liquid during an ongoing multi-step pipetting process.

[0234] Output screen page 200" features an input field located at the edge, in this case in the bottom right corner, labeled "Pause" and implementing a pause function. Touching this input field pauses the multi-step pipetting process, for example, after completion of dispensing step i=1 of N=3, which is also the eighth step of a 32-step programmed pipetting process. The input field marked with an exclamation mark and a surrounding arrow allows a pipetting process to be repeated if, for example, the eighth step just executed needs to be repeated due to a user error. Therefore, following the logic of the GUI, these input fields are not input fields that display the value of a pipetting parameter and whose touching would allow a change to a pipetting parameter in the next step.

[0235] In these embodiments of the pipetting device, "touching" an input field always results in an immediate effect; that is, the effect occurs without significant delay and preferably without an additional screen page being displayed between the moment of touch and the moment the effect is shown (e.g., opening an input interface), such as an information page indicating a delay, also known as a "waiting page." However, there may be GUI scenarios in which such an intermediately displayed information page is useful.

[0236] As shown in Fig. 2f, a progress bar can be useful for a multi-step pipetting process (here M=32), graphically illustrating the progress, which is also displayed numerically here ("8 / 32"). The notation "Protocol Lisa 250" in the output tile 222" indicates that, for example, a custom-programmed pipetting process with the user-defined name "Lisa 250" is being executed and simultaneously logged, i.e., saved in a log file of the pipetting device. The special button 201" closes the output screen page 200", as generally intended. In general, each output tile is not an input tile; therefore, it does not contain an input field whose touch would have a function and thus does not allow any input.

[0237] The concept of distinguishing between an input screen and an output screen, implemented through external differentiation, offers a significant ergonomic advantage in operation, as the user can easily recognize whether they are currently in a pipetting process—possibly interrupted and awaiting input—or in a settings mode. The input and output screen concept thus implies such input and output modes for the pipetting device, which are easily distinguishable for the user. Preferably, only touching the separate input area (special button)—or a completed pipetting process, which can trigger an automatic return to an input screen, particularly the home screen—allows the user to change parameter values ​​or select parameters again.This separation prevents, in particular, accidental changes to parameter values ​​while the "do" mode is running, which could potentially ruin laboratory work and result in a significant loss of value. On the other hand, switching from "set" to "do" mode by pressing the control element offers considerable user convenience and is intuitively understandable. This also contributes significantly to ergonomics and an efficient workflow. An output screen page (e.g., 200) is preferably characterized by the fact that the display fields or tiles contained in the output screen page, e.g., output tile 203, are purely informational; that is, they do not serve as input fields, and touching them does not result in any action, especially not initiating any input option.This does not apply to a separate control panel on the output screen page, in this case the special button 201, touching which cancels the output mode and leads to the display of an input screen page on the screen and may, in particular, lead to the termination of a pipetting process or pipetting program that may still be running.

[0238] Fig. 2g shows an image of the head area of ​​a pipetting device according to the invention, in which a mixing function screen page is displayed, which occurs in a mixing function mode of the pipetting device according to an embodiment of the invention. This mixing function screen page 150 is displayed when the user performs a swipe gesture to the right from the home screen 100. Similarly, in Fig. 4, the mixing function screen page 150 is displayed before the user reaches screen page 130. The latter can be displayed if another swipe gesture to the right is detected from the mixing function screen page 150. The mixing function screen page 150 includes

[0239] 1. Display element 155 for displaying the current total number of mixing steps Nmix_total, which are counted by a counter parameter Nmix not shown here,

[0240] 2. Input field 153 for displaying and entering the mixing volume VM

[0241] 3. Input field 154 for displaying and entering the pipetting speeds vm1 (uptake) and vm2 (output).

[0242] The user interface device has a mixed-function input element 9a, 10a, which is the actuating element 9a or the rocker half 10a.The data processing unit 6 is programmed to execute a mixing process which includes at least one mixing step and is defined by at least one pipetting parameter which includes at least one mixing volume VM, by, in each case program-controlled, a) capturing user input via the mixing function input element 9a, 10a and b) starting and executing the mixing process based on the input captured via the mixing function input element, during which the movement element is controlled such that a mixing step is carried out or mixing steps are carried out successively and are countable or counted by a parameter N_mix, wherein in each mixing step a mixing volume VM of the sample is taken into the pipetting container by the corresponding movement of the movement element and subsequently dispensed again.

[0243] The data processing unit 6 is programmed to execute the mixing process in order to, in step a), capture user input by pressing and holding the mixing function input element, and either, in b), after completion of a mixing step, start and / or execute another mixing step, provided that user input by pressing and holding the mixing function input element is captured at a time after the start of the mixing process and before its completion, or at the time of its completion, so that the number Nmix of mixing steps increases by 1, which is displayed in display field 155, or, in b), to terminate the mixing process if no user input by pressing and holding the mixing function input element is captured at that time, so that the current value Nmix at that time determines a pipetting parameter Nmix_total (Nmix_total = Nmix).

[0244] The data processing unit 6 is programmed to perform the mixing operation, in b) to automatically continue the mixing operation successively by automatically increasing the number Nmix of the mixing steps, and, if a new user input is detected during the mixing step via the user interface unit, in particular the mixing function input element, to terminate the mixing operation after the mixing step has been carried out, so that the current value Nmix at the time of the new input determines the pipetting parameter Nmix_total (Nmix_total = Nmix).

[0245] The total number of Nmix_total steps, which defines the total number of mixing steps in the mixing process, is not definitively determined when the input used to start the mixing process is successful. Rather, the total number depends on the user's actions and is only fixed when the user ends the mixing function mode by swiping left and returns to the home screen.

[0246] The mode input device is implemented via the touchscreen 4 and includes gesture recognition to detect a user swipe, whereby in this case, a "swipe to the right" from the home screen 100 activates the mixing function mode and displays the mixing function screen page 150. The data processing device is programmed to perform the mixing operation by: i) capturing user input via the mode input device (4), ii) activating a mixing function mode of the pipetting device based on the input via the mode input device, and iii) performing steps a) and b), in particular only when the mixing function mode has been activated.

[0247] The mode input device is therefore a touch-sensitive screen 4 (touch screen) of the user interface device, which is operated by a gesture forming the input, wherein the gesture is a swipe of the screen in a predefined direction, here a direction perpendicular to the longitudinal axis of the pipetting device, here a lateral direction perpendicular to a four-sided, cuboid screen, in particular a direction to the right, wherein the swipe leads to the activation of the mixing function mode if and only if the screen page currently displayed on the screen is the home screen 100.

[0248] In the pipetting device 1, the total number Nmix_total of mixing steps Nmix completed during the mixing process is recorded by capturing the parameter Nmix_total as part of log data and storing it in a data storage device 7, wherein the log data also includes the pipetting parameters VM (mixing volume) and vm (pipetting speed during the mixing process) used during the mixing process, or the pipetting speed vm1 of the sample intake and the pipetting speed vm2 of the sample discharge.The data processing unit 6 is programmed to display the mixing function screen page 150 on a screen 4 of the user interface unit, which displays the current total count Nmix_total detected during the activity of the mixing function mode, and wherein iii) it is possible to continue the mixing operation so that the total count Nmix_total is further increased; iv) the total count parameter Nmix_total is not set to zero and the counter parameter is not set to zero when a release of the mixing function input element is detected during a press and hold of the mixing function input element after the start of the mixing step and up to a point before the end of the mixing step, and in particular, the mixing operation is continued when a further press and hold of the mixing function input element is detected after this point or at the end of the mixing step.

[0249] The data processing unit 6 is programmed so that in mixing function mode, a single press and immediate release, i.e., a tap, of the mixing function input element 9a, 10a results in the execution of exactly one complete mixing step.

[0250] The pipetting device 1 has exactly one first actuating element 9a and one second actuating element 9b, which can be actuated separately from each other, in particular by means of a rocker switch 10. The data processing unit 6 is programmed to detect the actuation of the first or second actuating element 9a or 9b by the user and to start the pipetting process defined according to the parameter set.

[0251] The pipetting device comprises the rocker switch 10 and the first 9a and the second actuating element 9b, which can be actuated independently of each other by the rocker switch 10. Pressing a first pressure surface 10a of the rocker switch 10 actuates the first actuating element 9a, and pressing a second pressure surface 10b of the rocker switch actuates the second actuating element 9b. The first and second pressure surfaces are haptically distinguishable. In particular, the first pressure surface 10a is convex (curved outwards), and the second pressure surface 10b is concave. This allows the user to locate the desired actuating element or side (pressure surface) of the rocker switch by touch without visual control; operation is intuitive and ergonomic.

[0252] The pipetting device 1 has a housing 11, which is designed as a handle for holding the pipetting device with a single hand by the user, and which has an axial section 11 containing the moving element, along whose longitudinal axis A the moving element 3 extends. The operating rocker is mounted on a thumb rest surface, which is arranged at an angle 80° < a < 180°, namely preferably oc = 100°–150°, preferably 130° to the longitudinal axis and is particularly inclined downwards. “Downwards” refers to an orientation of the pipetting device with its longitudinal axis A vertically aligned and the pipette tip 19 pointing in the direction of gravity. The angular arrangement of the platform section of the operating rocker results in an ergonomically arranged thumb rest surface.The thumb rest area is arranged starting from the longitudinal axis and is located, in particular, perpendicular to a plane that runs through the longitudinal axis A and perpendicular to a surface of the planar screen 4. The position of the platform section, which is at the same height as the hand rest with respect to the longitudinal axis, also results in advantageous ergonomics.

[0253] The head section 14 has a front surface 14a inclined to the longitudinal axis A, which is formed by the surface of the screen 4 and a surrounding frame. The screen occupies approximately 80% of the front surface. The frame front surface 14a lies in a first plane, and the planar screen 4 lies in a second plane that is identical to the first. This allows the user to easily touch even the edges of the screen, thus optimizing the use of the available area of ​​the touchscreen 4. At the same time, the screen edges are not exposed and are protected by the frame front surface 14a.

[0254] The housing 11 has the connecting section 2 (working cone) for at least one pipetting container 19 and the ejection button 15, the contact surface of which can be moved along a distance into the housing by pressing the ejection button, wherein the pipetting device is arranged so that when the end of this distance is reached the ejection of the pipetting container, in particular the pipette tip, takes place or an electrical signal is generated that triggers the ejection of the at least one pipetting container.

[0255] Fig. 5a: The data processing device is programmed to display a screen page 102 on the screen, which contains at least one first input tile 103, here 103a, 103b, 103c, which displays the value of at least one first pipetting parameter (here: 103a: V=120pl, 103b: v= (v1 , v2) with delivery rate v1=level 8, intake rate=level 8; number n of steps n=3) and whose touch opens an input interface that allows the user to enter the value of the at least one first pipetting parameter, wherein this input interface is a screen area in which, in particular, a numeric keypad is displayed, the number keys of which can be touched individually and used by the user to enter a sequence of digits that defines the value of the at least one first pipetting parameter. The input tiles are here white rectangular areas of the screen, which are defined by appropriate drawing or...The contrast with the gray background is noticeable, and their width b extends over almost the entire width B of screen 4. This results in advantageous ergonomics. While this applies to the aforementioned input tiles, it does not necessarily apply to all input fields on the input screen page, see Fig. 1d. The input interface here is the screen area in a new screen page 100a, shown on the right in Fig. 5a, which is displayed as superimposed on screen page 100. Similar screen areas 100b, 100c open when the input tiles 103b, 103c of the associated pipetting parameters v=(v1 , v2) and n are opened. Or, correspondingly, a screen area with input fields in a list of possible fractions f= 0.1 to 1.0, if, instead of the absolute number, the division of the total volume V (e.g., by dispensing steps into sub-steps or sub-volumes) is to be set.

[0256] Fig. 3a: Particularly preferably, the data processing device 6 is programmed to display a screen page 100, here implemented as a home screen, on the screen 4 for displaying the pipetting parameters of a parameter set of pipetting parameters, wherein the screen page contains at least one first input tile 103 (here three input tiles 103a, 103b, 103c) which displays the value of at least one first pipetting parameter of a basic parameter set (here: V, v=(v1 , v2), n) and whose touching an input interface, here in Fig. 5a e.g.The screen area with numeric keypad on screen page 100a opens, allowing the user to enter the value of at least one first pipetting parameter, where screen page 100 contains an input field 101, touching which causes the display, here on a separate screen page 110, in a selection list, which contains a list of short descriptions (here: "quick mix", "reverse", "step time", "auto blow off" etc.) of further selectable pipetting parameters (here qm, rev, st, abo etc.), from which the user can select at least one second pipetting parameter (here qm, rev, st, or abo etc.).) can select which is added to the at least one first pipetting parameter of the basic parameter set in order to define the pipetting parameters of the parameter set of pipetting parameters that determine the pipetting process, whereby after the selection of the at least one second pipetting parameter is completed, the selection list is closed and screen page 100 is displayed again, which now displays at least one second input tile in addition to the at least one first input tile 103, which displays the value of the at least one second pipetting parameter (here qm, rev, st, or abo etc.) and touching which opens an input interface 100d etc., which allows the user to enter the value of the at least one second pipetting parameter.

[0257] As an alternative to displaying an alternative screen page 110, which shows the selectable parameters and from which one returns to the home screen 100 after selecting / deselecting the desired parameters by touching the input field 104, the content of the home screen can also be extended, e.g., by a downwardly extended area 106 accessible by scrolling (vertical swiping or tapping on the control panel 105), or even further areas, in which the possible pipetting parameters are listed and can be selected / activated, and subsequently their values ​​can be edited, as shown in Fig. 3b.

[0258] The aforementioned invention represents a particularly advantageous aspect of the innovative operating concept of a pipetting device. User studies have shown the inventors that a significant portion of users can achieve a more efficient workflow with a pipetting device in which the user defines the desired pipetting processes according to their own preferences by supplementing an existing, e.g., a proven or basic parameter set, with pipetting parameters, i.e., with functions or features. This approach obviously leads to the goal of defining a customized pipetting process with optimal efficiency. In particular, if a basic parameter set is provided on a screen, especially a home screen, which is immediately executable, a successful user experience is offered immediately, without the need for lengthy study of operating instructions.Within a short learning curve, users can navigate the list of available pipetting parameters, thus more efficiently utilizing the extensive functionality of an electric pipetting device. This is particularly relevant for the large group of users who struggle to learn the existing—more or less complex—operating modes of conventional pipetting devices, which represent various application scenarios, and ultimately settle for the simplest modes. The innovative concept encourages inexperienced users to learn the functions while offering experienced users complete flexibility.

[0259] Preferably, the data processing device 6 is programmed to display information on the screen if the value entered by a user via an input interface 100a, 100b, 100c, 100d for a pipetting parameter is invalid, and preferably

[0260] • at least one correction button is displayed, touching which automatically executes at least one correction process instead of the value entered by the user, which can have the following configurations:

[0261] Instead of the invalid value, a valid value is automatically set;

[0262] At least one alternative pipetting parameter to the aforementioned pipetting parameter is selected and, in particular, assigned the user's value or another suitable value;

[0263] The user's input is undone, and in particular, re-entry is enabled;

[0264] And / or

[0265] • An error message is displayed; and / or

[0266] • The change to the previously current value is ignored and the previously current value is retained;

[0267] And / or

[0268] • Another non-combinable pipetting parameter that represents a non-combinable function will be automatically deselected.

[0269] Preferably, the data processing device 6 is programmed to display a screen page 100 on the screen 4, which displays a list of input tiles 103a, 103b, 103c, which in particular extend substantially over the entire screen page.

[0270] Fig. 4: The data processing device 6 is programmed to display a start screen page 100 on the screen 4, which is replaced by a second screen page 120 by a sideways swipe gesture and which is replaced by a screen page 150 (mix-function screen page) by a sideways swipe gesture in the opposite direction, and optionally further replaced by another screen page 130, wherein in particular (see Fig. 6) the second screen page 120 has a list of input fields, each input field having a short name (here e.g.the input tile with the short name “measure volume”) and wherein touching the input field loads a predetermined parameter set that defines a predetermined pipetting operation, wherein, in particular, after touching this input field, another screen page 120a is displayed; and wherein, in particular, screen page 130 has a list of input fields, each input field bearing a short name (here, for example, the input tile with the short name “150pl steps 6”, etc.) and wherein touching the input field loads a historical parameter set, used in the past and automatically saved, that defines a historical pipetting operation, wherein, in particular, after touching this input field, another screen page is displayed.

[0271] Fig. 1e shows the system 300 for inputting pipetting parameters, comprising the handheld pipetting device 1, an external data processing device 50, which has an external screen 51 and a data processing unit 52 programmed to display an external input screen page on the external screen for displaying and inputting the pipetting parameters of a parameter set of pipetting parameters, wherein the external input screen page and the input screen page of the pipetting device are essentially the same in content, wherein the system is configured to transfer the pipetting parameters defined on the external data processing device to the pipetting device and to use them there to define a pipetting operation.

[0272] Fig. 7a shows, using two images of an input screen page 100_3 of a pipetting device according to the invention as an exemplary embodiment, the functionality of the GUI of the pipetting device to mark a current parameter set as a favorite, which is then saved as a favorite and, in particular, displayed as a selectable list entry, namely as a correspondingly informative input tile, on a favorites screen page. An input field marked accordingly with a favorite symbol (asterisk) detects a user touch, as a result of which a pipetting parameter set defined in the input screen page 100_3 is saved as a favorite, which is illustrated by the color change of the favorite symbol.

[0273] Fig. 7b shows, using two screen pages of a pipetting device according to the invention as an exemplary embodiment, the functionality of the GUI of the pipetting device, that the input tile characterizing a favorite parameter set in the favorite screen page 121 has an input field, touching which transfers the parameters of the favorite parameter set to the home screen, namely the input screen page 100_4, which is then displayed, in which the parameter values ​​and / or the parameter selection of the favorite parameter set can be changed.

Claims

Patent claims 1. Handheld pipetting device (1) for pipetting at least one sample, with a connecting section (2) for connecting at least one pipetting container to the pipetting device, with a movement element (3) for aspirating the at least one sample into the at least one pipetting container (19), holding the sample in the at least one pipetting container and dispensing the sample from the at least one pipetting container when performing a pipetting operation defined by pipetting parameters, with an electrical control device (5) comprising a data processing device (6) programmed to control the movement element depending on the pipetting parameters, and with a user interface device (4) for outputting information to a user and for recording user input, characterized in that the user interface device includes a mixing function input element (9a;10a) and the data processing device (6) is programmed to execute a mixing process which includes at least one mixing step and is defined by at least one pipetting parameter which includes at least one mixing volume VM, by, in each case program-controlled, a) capturing user input via the mixing function input element and b) starting and executing the mixing process based on the input captured via the mixing function input element, during which the movement element is controlled such that a mixing step is performed or mixing steps are successively performed and are countable or counted by a parameter N_mix, wherein in each mixing step a mixing volume VM of the sample is taken into the pipetting container by the corresponding movement of the movement element and subsequently dispensed again.; 2. Pipetting device according to claim 1, wherein the data processing device is programmed to execute the mixing process, a) to capture user input by pressing and holding the mixing function input element, and either b) to start and / or perform another mixing step after the completion of a mixing step, provided that user input by pressing and holding the mixing function input element is captured at a time after the start of the mixing process and before its completion or at the time of its completion, so that the number Nmix of mixing steps increases by 1, or b) to terminate the mixing process if no user input by pressing and holding the mixing function input element is captured at that time, so that the current value Nmix at that time determines a pipetting parameter Nmix_total (Nmix_total = Nmix).

3. Pipetting device according to claim 1, wherein the data processing device is programmed to perform the mixing process, in b) to automatically continue the mixing process successively by automatically increasing the number Nmix of the mixing steps, and, if a new input from the user is detected during the mixing step via the user interface device, in particular the mixing function input element, to terminate the mixing process after the mixing step has been carried out, so that the current value Nmix at the time of the new input determines the pipetting parameter Nmix_total (Nmix_total = Nmix).

4. Pipetting device according to one of the preceding claims, wherein a total number Nmix_total, which defines the total number of mixing steps of the mixing process, is not yet definitively determined when the input serving to start the mixing process is successful.

5. Pipetting device according to one of the preceding claims, wherein the user interface device comprises a mode input device (4') distinct from the mixing function input device, and the data processing device is programmed to perform the mixing operation, i) to detect user input via the mode input device, and ii) to activate a mixing function mode of the pipetting device based on the input via the mode input device, and iii) to perform steps a) and b), in particular only when the mixing function mode has been activated.

6. Pipetting device according to claim 5, wherein the mode input device 4' i) either includes a touch-sensitive screen 4 (touch screen) of the user interface device, which is operated by a gesture forming the input, wherein the gesture is in particular a swiping of the screen, in particular in a predefined direction, in particular a direction perpendicular to the longitudinal axis of the pipetting device, in particular a side-parallel or side-perpendicular direction in a cuboid screen having four sides, in particular a direction to the right, wherein the swiping leads in particular - preferably exactly or only - to the activation of the mixing function mode if the screen side currently displayed in the screen is the home screen.ii) or includes a control panel in a screen page displayed by a touch screen of the user interface device, iii) or has a sensor element, in particular a switch, button or capacitive measuring field, by means of which the user's input can be detected. is.

7. Pipetting device according to claim 5 or 6, comprising at least one actuating element which can be actuated by a user's finger pressure and whose actuation starts a pipetting process defined according to a parameter set of pipetting parameters when the mixing function mode is not activated, wherein the at least one actuating element forms the mixing function input element when the mixing function mode is activated.

8. Pipetting device according to one of the preceding claims, wherein the total number Nmix_total of the mixing steps completed during the mixing process is recorded by capturing the parameter Nmix_total as part of log data and in particular storing it in a data storage device (7), wherein the log data also includes in particular the pipetting parameters VM (mixing volume) and vm (pipetting speed during the mixing process) used during the mixing process.

9. Pipetting device according to one of the preceding claims, wherein a parameter set of pipetting parameters fully defines a planned and / or a previously performed pipetting operation and includes at least one pipetting parameter VP that defines a pipetting volume of the pipetting operation and is referred to as the pipetting parameter “pipetting volume”, wherein the data processing device for executing the mixing operation is programmed to derive the mixing volume VM, which is referred to as the pipetting parameter “mixing volume”, from the at least one pipetting parameter VP defining the pipetting volume.

10. Pipetting device according to claim 9 or any of the other preceding claims, wherein the data processing device is programmed to that the mixing volume VM is derived from a predefined function VM(VP), which assigns a value of the mixing volume VM to each value of the pipetting parameter VP, wherein preferably this assignment can be carried out by using a predefined assignment table VM(VP), in particular by reading values ​​VM as a function of VP from a database containing value pairs (VP ​​ / VM)i that are stored in a memory device of the pipetting device, or wherein preferably this assignment can be carried out by a mathematical operation performed by the control device that calculates VM(VP) according to a predefined formula.

11. Pipetting device according to claim 6, wherein the data processing device is programmed to: c1) as a result of actuating the mode input device on the screen, display a screen page with a display element that outputs the pipetting parameter VM, wherein this display preferably occurs together with the activation of the Quickmix mode, in particular substantially simultaneously, wherein the display element is preferably an input field, touching which opens an input interface on the screen that allows the user to change the value of the mixing volume VM; and / or c2) display a display element on the screen that outputs a pipetting rate vm to be used in the mixing step, wherein preferably the display element showing the pipetting rate is an input field, touching which opens an input interface on the screen that allows the user to change the value of the pipetting rate vm.

12. Pipetting device according to one of the preceding claims, wherein the data processing device is programmed to display a mixing function screen page in a screen of the user interface device, in the total number Nmix_total of mixing steps of the mixing process detected during the activity of the mixing function mode is displayed, wherein iii) it is possible to continue the mixing process so that the total number Nmix_total is further increased; iv) the total number parameter Nmix_total is not set to zero and the counter parameter is not set to zero if, during a press and hold of the mixing function input element after the start of the mixing step and up to a point before the end of the mixing step, a release of the mixing function input element is detected, and in particular, the mixing process is continued if, after this point or at the end of the mixing step, a further press and hold of the mixing function input element is detected.

13. Pipetting device according to one of the preceding claims, wherein the data processing device is programmed to pause the movement of the moving element for a duration t_stop between two mixing steps during a mixing process, wherein in particular 30 ms <= t_stop <=700 ms to give the user haptic feedback of the completed mixing step.

14. Pipetting device according to one of the preceding claims, wherein the data processing device is programmed such that, in mixing function mode, a single press and immediate release, i.e., a tap, of the mixing function input element results in the execution of exactly one complete mixing step.

15. Method for performing a mixing operation by a programmable, handheld pipetting device for pipetting at least one liquid sample, wherein the mixing operation includes at least one mixing step N_mix and is defined by at least one pipetting parameter which includes at least one mixing volume VM, and wherein the pipetting device comprises: • a connecting section for connecting at least one pipetting container to the pipetting device, • a moving element for aspirating the at least one sample into the at least one pipetting container, holding the sample in the at least one pipetting container and dispensing the sample from the at least one pipetting container during a pipetting process, • an electrical control device comprising a data processing unit programmed to control the motion element depending on the pipetting parameters, and • A user interface device for outputting information to a user and for capturing user input, comprising a mixing function input element, wherein the method comprises the steps executable by the data processing device of the handheld pipetting device: a) capturing user input via the mixing function input element; c) initiating and executing the mixing process based on the input captured via the mixing function input element; d) controlling the movement element during the mixing process such that a mixing step is performed or mixing steps are successively performed and counted by a parameter N_mix, wherein in each mixing step the mixing volume VM of the sample is taken into the pipetting container and subsequently dispensed by the corresponding movement of the movement element.

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