Autophagy function-activating compound

Compounds with specific chemical structures activate autophagy, addressing the lack of effective autophagy activators in existing treatments, offering therapeutic benefits for a range of diseases by enhancing autophagy function.

WO2026029115A1PCT designated stage Publication Date: 2026-02-05MORESCO +2
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Patent Information

Application Number
PCT/JP2025/027067
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-07-31
Filing Date
2025-07-30
Publication Date
2026-02-05

AI Technical Summary

Technical Problem

Existing compounds do not effectively activate autophagy function, which is crucial for treating various diseases and symptoms, including neurodegenerative diseases, infectious diseases, inflammatory diseases, and others, where enhancing autophagy can provide therapeutic benefits.

Method used

Development of compounds represented by specific chemical formulas that activate autophagy, including structures with indole skeletons and various substituents, which can form heterocycloalkanes or cycloalkanes, and are optionally substituted with specific groups, to enhance autophagy function.

Benefits of technology

The developed compounds effectively activate autophagy, providing therapeutic benefits for diseases caused by decreased autophagy or those whose pathology can be suppressed or ameliorated by enhancing autophagy, including neurodegenerative diseases, cardiovascular diseases, and others.

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Abstract

The present application discloses, as an embodiment of the invention, a compound, or a pharmaceutically acceptable salt thereof, that is useful as an agent for preventing or treating a disease caused by a decrease in autophagy function or a disease in which a pathological condition is suppressed or improved by the enhancement of autophagy function, and that is represented by formula (I) (in formula, the symbols are as described in the specification).
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Citation Information

Patent Citations

  • Autophagy function-activating compound

    WO2025183088A1