Biodegradable material evaluation system

Abstract

The present invention relates to a biodegradable material evaluation system. More specifically, the present invention relates to a system for evaluating the biodegradability of a biodegradable material by measuring changes in pH, temperature and current value.

Description

Biodegradable Material Evaluation System

[0001] The present invention relates to a system for evaluating biodegradable materials. More specifically, it relates to a system for evaluating the biodegradability of biodegradable materials by measuring changes in pH, temperature, and current values.

[0002]

[0003] Conventional evaluations of biodegradable materials involved coating biodegradable metals (Mg, Mo, etc.) with biodegradable materials (wax, PLGA, etc.) and immersing them in a solution to directly observe biodegradation or analyzing changes in electrical resistance.

[0004] However, when confirming with these experimental methods, quantitative analysis is difficult, and when measuring biodegradability through electrical resistance measurement, there is a problem in that the change varies depending on the thickness and width of the biodegradable metal.

[0005] In addition, there are problems such as additional time and cost incurred in the process of processing biodegradable metals, such as using expensive equipment such as PVD and CVD to perform deposition through multiple processes or forming the metal plate into the desired shape through laser processing.

[0006] During the biodegradation process, the biodegradation rate varies depending on the condition (temperature, pH) of the solution in which the material is immersed. However, there is a problem in that the change in pH cannot be confirmed in real time as biodegradation progresses, and circulation during the evaporation and liquefaction of the solution can also act as an error.

[0007]

[0008] This study aims to provide a more affordable method for evaluating biodegradable materials using readily available metal products. Furthermore, it aims to provide a biodegradable material evaluation system capable of quantitatively and continuously analyzing complex biodegradation processes using changes in pH and current values.

[0009]

[0010] A biodegradable material evaluation system according to one embodiment of the present invention may include a biodegradable material solution, a metal wire coated with the biodegradable material, a chamber capable of storing the biodegradable material and the solution undergoing biodegradation, an ammeter, a pH sensor, and a temperature sensor.

[0011] A biodegradable material evaluation system according to one embodiment of the present invention may further include a chamber cap.

[0012] The above metal wire may be at least one selected from the group consisting of magnesium and molybdenum.

[0013] The above solution may be PBS.

[0014] The material of the above chamber may be PDMS.

[0015]

[0016] A relatively simple method for assessing biodegradability of materials can be provided using common metal products. Using a pH sensor, current meter, and LED, complex biodegradation processes can be quantitatively and continuously analyzed.

[0017]

[0018] FIG. 1 illustrates a biodegradable material evaluation system according to one embodiment of the present invention.

[0019] Figure 2 illustrates a process of coating a biodegradable material according to one embodiment of the present invention.

[0020] FIG. 3 illustrates an SEM image of a magnesium wire according to one embodiment of the present invention.

[0021] FIG. 4 illustrates an SEM image of a magnesium wire coated with a biodegradable material according to one embodiment of the present invention.

[0022] Figure 5 shows the size of a magnesium wire coated with a biodegradable material according to one embodiment of the present invention.

[0023] Figure 6 shows a synthesis diagram of a biodegradable material according to one embodiment of the present invention.

[0024] Figure 7 is a graph showing real-time resistance values ​​measured using a biodegradable material evaluation system according to one embodiment of the present invention.

[0025] Figure 8 is a graph showing the average daily resistance value measured using a biodegradable material evaluation system according to one embodiment of the present invention.

[0026]

[0027] Hereinafter, embodiments of the present invention will be described in detail with reference to the attached drawings so that those skilled in the art can easily implement the present invention.

[0028] However, the following description is not intended to limit the present invention to a specific embodiment, and when explaining the present invention, if it is determined that a detailed description of a related known technology may obscure the gist of the present invention, the detailed description is omitted.

[0029] The terminology used herein is merely for the purpose of describing specific embodiments and is not intended to limit the present invention. The singular expression includes the plural expression unless the context clearly indicates otherwise. In the present invention, it should be understood that the terms "comprise" or "have" indicate the presence of a feature, number, step, operation, component, or combination thereof described in the specification, but do not preclude the presence or addition of one or more other features, numbers, steps, operations, components, or combinations thereof.

[0030] Additionally, terms including ordinal numbers, such as "first," "second," etc., which will be used hereinafter, may be used to describe various components, but these components are not limited by these terms. These terms are used solely to distinguish one component from another. For example, without departing from the scope of the present invention, a first component could be referred to as a second component, and similarly, a second component could also be referred to as a first component.

[0031] Additionally, when it is said that a component is "formed on" or "laminated on" another component, it should be understood that it may be formed or laminated directly on the entire surface or one side of the other component, but there may also be other components present in between.

[0032] A biodegradable material evaluation system according to one embodiment of the present invention may include a biodegradable material solution, a metal wire coated with the biodegradable material, a chamber capable of storing the biodegradable material and the solution undergoing biodegradation, an ammeter, a pH sensor, and a temperature sensor.

[0033] A biodegradable material evaluation system according to one embodiment of the present invention may include a solution of a desired shape within the chamber. Furthermore, a biodegradable material evaluation system according to one embodiment of the present invention may position a metal wire coated with a biodegradable material within the chamber solution. A biodegradable material evaluation system according to one embodiment of the present invention may be configured to be sealed via a chamber cap.

[0034] The above biodegradable material can be used as a coating method on a metal wire. This method has the advantage of being able to evaluate biodegradable materials without the need for conventional deposition processes utilizing CVD or PVD.

[0035] A biodegradable material evaluation system according to one embodiment of the present invention may further include a chamber cap.

[0036] The chamber cap may serve to seal the biodegradable material evaluation system. The chamber cap may minimize evaporation and liquefaction of the solution.

[0037] Sealing the chamber with the chamber cap offers the advantage of making it easy to change the solution inside or perform additional procedures using a syringe. Furthermore, the chamber cap facilitates the easy removal of air bubbles and other substances generated during the biodegradation process.

[0038] The above chamber may include a PDMS well.

[0039] The above PDMS can serve to fill the solution and fix the wire.

[0040] The above biodegradable material may be one or two or more selected from PCL (Polycaprolactone), PHB (Polyhydroxybutyrate), PLGA (poly(lactic-co-glycolic) acid) and biodegradable PU (Poly urethane).

[0041] The above metal wire may be at least one selected from the group consisting of magnesium, gallium, aluminum, molybdenum and mixed wires.

[0042] The metal wire may preferably be a magnesium wire. The magnesium wire may have a thin thickness. In addition, when using a magnesium wire, a fast dissolution rate may be achieved.

[0043] The above solution may be PBS.

[0044] The material of the chamber may be PDMS. The chamber must have excellent heat resistance and stable physical properties. Furthermore, it must exhibit excellent chemical resistance to solutions used for biodegradation.

[0045] The chamber must be constructed of a material that is stable against acidification occurring during the biodegradation process. Furthermore, the chamber must be constructed of a material that is stable against alkaline solutions used for accelerated decomposition. The chamber must also be constructed of a material that is stable even at high temperatures above 70°C.

[0046] If the material of the above chamber is PMDS, it has very low water permeability, making it possible to maintain the interior of the chamber stably. Furthermore, even when using the syringe, the PDMS material exhibits excellent resilience, minimizing leakage through the syringe opening.

[0047] A biodegradable material evaluation system according to one embodiment of the present invention may include a Micro LED.

[0048] The above Micro LED allows for visual confirmation of current changes without the need for separate equipment. When the biodegradable film dissolves, the metal wire connection is severed, causing the previously lit LED to turn off.

[0049] The above pH sensor can acidify the surrounding solution as the biodegradable material dissolves. Accordingly, the degree of biodegradability can be measured using the pH sensor.

[0050] The above ammeter gradually increases in resistance as the biodegradable film disappears and the metal wire melts, eventually becoming thinner and eventually completely decomposing, resulting in a high resistance value. Measuring these changes can be used to assess biodegradability, determining how long the biodegradable film protects the metal wire.

[0051]

[0052] Example 1. Fabrication of PDMS well

[0053] Synthesize PDMS A:B in a ratio of 10:1. A is the main ingredient of sylgard products, and B is a curing agent. After removing air bubbles from the PDMS in a vacuum oven, pour 25g into a petri dish and harden in a 70°C oven for 2-3 hours. Place an empty bottle on top of the hardened PDMS, pour another 30g of PDMS, and harden in the oven for 2-3 hours to complete the PDMS well.

[0054] Remove the empty bottle and cut it open to accommodate wires next to the bottle. You can cut as many wires as you want. Insert the wire coated with a biodegradable material into the cut. Attach a sensor of your choice, such as a temperature sensor or pH sensor, inside.

[0055] Pour 3g of PDMS into a small petri dish and harden in an oven for 2-3 hours to create a lid. Place the lid on the PDMS well where the empty bottle was, then coat the surrounding area with PDMS to secure it in place. Place a heavy weight between the lid and the PDMS well to prevent air bubbles inside the newly applied PDMS, and harden in an oven. Using a thin-needle syringe, inject PBS into the sealed PDMS well.

[0056]

[0057] Experimental Example 1. Biodegradability Measurement Using Micro LED

[0058] As the metal wires within the biodegradability assessment system progress, they become thinner. Consequently, the amount of current measured changes. Therefore, biodegradability can be measured by analyzing LED luminosity, which can directly influence the numerical changes in the ammeter.

[0059]

[0060] Experimental Example 2. Biodegradability Measurement Using pH Measurement

[0061] As biodegradation progresses within a biodegradable material evaluation system, the biodegradable material acidifies the surrounding solution. This acidification can be used as an important indicator for assessing biodegradability. Real-time monitoring allows for quantitative measurement and analysis of biodegradability.

[0062]

[0063] Experimental Example 3. Biodegradability Measurement Using an Ammeter

[0064] The thickness of the metal wire within the biodegradable material evaluation system gradually decreases as biodegradation progresses. This can be assessed by an increase in resistance. Since this change alters the amount of current flowing through the circuit, an ammeter can be used to monitor real-time current changes and measure the resistance of the metal wire. Biodegradability can be measured and evaluated through changes in metal wire resistance.

Claims

1. Biodegradable materials; solution; Metal wire coated with biodegradable material; A chamber capable of storing biodegradable materials and solutions undergoing biodegradation; ammeter; pH sensor; a temperature sensor; Biodegradable material evaluation system.

2. In paragraph 1, Including a chamber cap, Biodegradable material evaluation system.

3. In paragraph 1, The above metal wire is at least one selected from the group consisting of magnesium and molybdenum. Biodegradable material evaluation system.

4. In paragraph 1, The above solution is PBS, Biodegradable material evaluation system.

5. In paragraph 1, The material of the above chamber is PDMS. Biodegradable material evaluation system.

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