Triphasic transdermal diffusion apparatus simulating pollutant entry into human body through skin

Abstract

A triphasic transdermal diffusion apparatus simulating pollutant entry into the human body through the skin, comprising: a skin equivalent (3), used for simulating human skin tissue; a circulation system, used for simulating a human blood circulation process; a supply chamber (6), used for supplying a preset type of pollutant; a sealing cover (8), fitting with the top of the supply chamber (6); a positioning device (5) having a fitting connection with the supply chamber (6), the positioning device (5) having a downwardly convex structure and lifting the skin equivalent (3), so that the skin equivalent (3) remains in a taut state; and a receiving cell (1), used for receiving a substance that passes through the skin equivalent (3) and enters the circulation system. The present apparatus is capable of analyzing the amounts of solids, liquids and gases permeating through skin, thereby enabling investigation of the amounts of various pollutant types and pollutant concentrations passing through the skin under different skin tautness states, improving the accuracy of experiments.

Description

A three-phase transdermal diffusion device for simulating the entry of pollutants into human body through skin TECHNICAL FIELD

[0001] The present application relates to a simulation device, in particular to a three-phase transdermal diffusion device for simulating the entry of pollutants into human body through skin. BACKGROUND

[0002] There are three ways for pollutants to enter human body, namely oral, respiratory and skin contact. However, compared with the first two contact ways, the way of pollutants entering human body through skin contact is often underestimated and ignored. Now the devices for studying the percutaneous absorption of pollutants mostly use transdermal diffusion cells, transdermal diffusion instruments and the like, and the core transdermal diffusion cell in these devices mostly uses Franz diffusion cell and modified Franz diffusion cell. The experimental method is to clamp the skin required for the experiment in the diffusion cell, and then place the diffusion cell in the transdermal diffusion device. By heating the diffusion cell, the drug to be tested on the upper side of the skin permeates through the skin of the diffusion cell and infiltrates into the receiving liquid on the lower side of the skin. The concentration in the receiving liquid is detected periodically, the amount of drug permeating through the skin is analyzed, experimental data is recorded, and finally average data is obtained through multiple evaluations.

[0003] Most of the existing transdermal diffusion cells are designed for drugs and reagents, so the research objects are mostly liquids and solids, and there is a lack of research on gaseous objects. In addition, multiple sampling and liquid supplementing operations are required during the experiment, which will cause the concentration of the receiving liquid to be inconsistent before and after the operation, thereby affecting the accuracy of the experiment. SUMMARY

[0004] The present application overcomes the shortcomings of the prior art and provides a three-phase transdermal diffusion device for simulating the entry of pollutants into human body through skin.

[0005] To achieve the above purpose, the technical scheme adopted by the present application is as follows:

[0006] The present application provides a three-phase transdermal diffusion device for simulating the entry of pollutants into human body through skin in the first aspect, comprising:

[0007] A skin equivalent for simulating the skin tissue of human body;

[0008] A circulatory system for simulating the blood circulation process of human body;

[0009] A supply chamber for supplying pollutants of a predetermined type;

[0010] A sealing cover cooperated with the top of the supply chamber;

[0011] A positioner cooperated with the supply chamber, the positioner being a downward convex structure, the positioner lifting the skin equivalent so that the skin equivalent is kept in a taut state;

[0012] A receiving pool for receiving the substance through the skin equivalent and entering into the circulation system.

[0013] Further, in the three-phase transdermal diffusion device for simulating the penetration of pollutants through the skin into the human body, the lower part of the positioner is further connected with a fixing sheet, and the fixing sheet is a hollow structure, and the positioner is placed at the hollow structure.

[0014] Further, in the three-phase transdermal diffusion device for simulating the penetration of pollutants through the skin into the human body, the fixing sheet is fixedly connected with the fixing device, and the fixing sheet is fixedly connected with the skin equivalent through the fixing sheet.

[0015] Further, in the three-phase transdermal diffusion device for simulating the penetration of pollutants through the skin into the human body, air vents are arranged on both sides of the supply chamber, and air pipes are connected at the air vents.

[0016] Further, in the three-phase transdermal diffusion device for simulating the penetration of pollutants through the skin into the human body, the circulation system comprises a receiving liquid storage tank and a peristaltic pump, and the receiving liquid in the receiving liquid storage tank flows at a preset flow rate through the action of the peristaltic pump, and the receiving liquid flows through the receiving pool, and the liquid surface is closely attached to the lower end of the skin equivalent.

[0017] Further, in the three-phase transdermal diffusion device for simulating the penetration of pollutants through the skin into the human body, the three-phase transdermal diffusion device further comprises a sampling pool and a fixing device, the sampling pool is connected with the circulation system, and the fixing device is provided with an extraction needle and an adjusting fixing device.

[0018] Further, in the three-phase transdermal diffusion device for simulating the penetration of pollutants through the skin into the human body, the lower convex structure comprises a first convex body and a second convex body, at least two groups of telescopic rods are arranged on the first convex body, an elastic protruding part is arranged on one end of the telescopic rod, and the elastic protruding part is connected with a groove in the second convex body.

[0019] The second aspect of the present application provides a data analysis method of a three-phase transdermal diffusion device for simulating the penetration of pollutants through the skin into the human body, which is applied to any of the three-phase transdermal diffusion devices for simulating the penetration of pollutants through the skin into the human body, and comprises the following steps:

[0020] Through the three-phase transdermal diffusion device for simulating the penetration of pollutants through the skin into the human body, the permeation amount data information of each pollutant information under each tight state is obtained, and a pollutant permeation amount data prediction model is constructed according to the permeation amount data information of each pollutant information under each tight state.

[0021] acquire the type of pollutants in the target area and the concentration information of the pollutants, and input the type of pollutants in the target area and the concentration information of the pollutants into the pollutant permeation data prediction model to acquire the permeation data information of each pollutant type of the target area under each tight state;

[0022] a preset permeation data threshold is set, and the abnormal target area and the candidate target area are identified according to the permeation data information of each pollutant type of the target area under each tight state and the permeation data threshold, and the pollutant source of the abnormal target area is traced;

[0023] the permeation data information of each pollutant type of the candidate target area is acquired, and the related planning information is generated according to the permeation data information of each pollutant type of the candidate target area, and the related planning information is pushed in a preset manner.

[0024] Further, in the data analysis method of the three-phase transdermal diffusion device for simulating the penetration of pollutants into the human body through the skin, a pollutant permeation data prediction model is constructed according to the permeation data information of each pollutant information under each tight state, which specifically includes:

[0025] a graph neural network is constructed, and the permeation data information of each pollutant information under each tight state is input into the graph neural network, the tight state is taken as the first graph node of the graph neural network, the pollutant information is taken as the second graph node of the graph neural network, and the permeation data is taken as the third graph node of the graph neural network;

[0026] a directed edge connection relationship is constructed, and the first graph node, the second graph node and the third graph node are constructed into a topological structure graph according to the directed edge connection relationship, a plurality of topological structure graphs are acquired, and a Chebyshev distance measurement algorithm is introduced to calculate the Chebyshev distance between the second graph nodes in the topological structure graph;

[0027] the topological structure graph corresponding to the second graph node with a Chebyshev distance not greater than a preset Chebyshev distance threshold is acquired, the second graph node is associated and expanded to generate an expanded second graph node, and the topological structure graph is updated according to the expanded second graph node to acquire an updated topological structure graph;

[0028] a pollutant permeation data prediction model is constructed based on a deep neural network, the updated topological structure graph is input into the pollutant permeation data prediction model for coding learning, and when the loss function of the pollutant permeation data prediction model converges to a preset value, the pollutant permeation data prediction model is output.

[0029] Further, in the data analysis method of the three-phase transdermal diffusion device for simulating the entry of pollutants into the human body through the skin, the relevant planning information is generated according to the permeation amount data information of each pollutant type of the candidate target area, specifically including:

[0030] A big data network is constructed, the tightness state information of the skin under each age group is obtained through the big data network, and the permeation amount data information of each pollutant type in the target area for each age group is obtained according to the tightness state information of the skin under each age group and the permeation amount data information of each pollutant type of the candidate target area;

[0031] When the permeation amount data information of each pollutant type in the target area for one of the age groups is greater than the permeation amount data threshold, the corresponding age group is taken as a warning age group of the target area;

[0032] When the permeation amount data information of each pollutant type in the target area for one of the age groups is not greater than the permeation amount data threshold, the corresponding age group is taken as a normal age group of the target area;

[0033] When there is data of a warning age group in the target area, the corresponding target area is set as a warning area, and when there is no data of a warning age group in the target area, the corresponding target area is set as a normally active area, and the relevant planning information is generated according to the warning area and the normally active area.

[0034] The present application solves the defects in the background art, and has the following beneficial effects:

[0035] The present application sets a three-phase transdermal diffusion device for simulating the entry of pollutants into the human body through the skin, which can analyze the amount of drug permeating through the skin for solid, liquid and gas objects, thereby exploring the amount of each pollutant type and the concentration information of pollutants permeating through the skin under each skin tightness state, and improving the accuracy of the experiment. On the other hand, the device is provided with a circulation system, which can perform multiple sampling through the circulation system, thereby performing multiple analysis on the sampled data, and improving the accuracy of the experiment. BRIEF DESCRIPTION OF DRAWINGS

[0036] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the drawings needed in the following embodiment or prior art description will be briefly introduced. Obviously, the drawings in the following description are only some embodiments of the present application, and those skilled in the art can also obtain other drawings of embodiments according to these drawings without creative labor.

[0037] Fig. 1 shows the overall structure of the transdermal diffusion device;

[0038] Fig. 2 shows a schematic diagram of a cross-sectional structure of the positioner;

[0039] Fig. 3 shows a schematic diagram of a perspective structure of the positioner.

[0040] In the figure: 1-receiving pool, 2-fixing seat, 3-skin equivalent, 4-fixing sheet, 5-positioner, 6-feeding chamber, 7-vent, 8-sealing cover, 9-sampling pool, 10-extraction needle, 11-fixing device, 12-receiving liquid storage tank, 13-peristaltic pump, 501-first convex body, 502-second convex body, 503-telescopic rod, 504-elastic convex part, 5021-groove. DETAILED DESCRIPTION

[0041] In order to enable a person skilled in the art to more clearly understand the above-mentioned purposes, features and advantages of the present application, the present application will be further described in detail below in conjunction with the drawings and specific embodiments, which are all simplified schematic diagrams and only show the basic structure of the present application in a schematic manner, and therefore only show the structures related to the present application. It should be noted that the embodiments in the present application and the features in the embodiments can be combined with each other without conflict.

[0042] In the description of the present application, it should be understood that the orientations or positional relationships indicated by the terms "center", "longitudinal", "transverse", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer" and the like are based on the orientations or positional relationships shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and therefore cannot be understood as indicating or implying that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as limiting the scope of protection of the present application. In addition, the terms "first", "second" and the like are only for descriptive purposes and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the technical features indicated. Therefore, the features defined with "first", "second" and the like can explicitly or implicitly include one or more of the features. In the description of the present application, unless otherwise specified, the meaning of "a plurality of" is two or more.

[0043] In the description of the present application, it should be noted that, unless otherwise explicitly specified and limited, the terms "mounting", "connection", "connection" should be understood in a broad sense, for example, it can be fixedly connected, or it can be detachably connected, or integrally connected; it can be mechanically connected, or it can be electrically connected; it can be directly connected, or it can be indirectly connected through an intermediate medium; it can be the communication inside two elements. For those skilled in the art, the specific meaning of the above-mentioned terms in the present application can be understood according to the specific circumstances.

[0044] For the purpose of promoting an understanding of the principles of the application, reference will now be made to the embodiments illustrated in the drawings. There is shown in the drawings, several embodiments of the application. It is readily apparent to those skilled in the art that the application can be practiced without departing from the scope of the application. Accordingly, the following description is presented for purposes of illustration and description, and is not intended to limit the scope of the application.

[0045] In combination with Fig. 1, the transdermal diffusion device comprises a receiving pool 1, a fixed seat 2, a skin equivalent 3, a fixed sheet 4, a positioner 5, a supply chamber 6, and air vents 7 on both sides of the supply chamber 6, which can be connected to air ducts, and a sealing cover 8 is matched to make the device have good sealing performance when the air is ventilated. If the donor is a liquid, the sealing cover 8 is removed, and the air vents 7 are blocked to prevent the liquid from leaking out, and the donor can enter from above the donor chamber. If the donor is a solid, such as a medicinal ointment, the donor can be directly applied to the skin equivalent 3.

[0046] The fixed sheet 4 is a hollow structure, and the positioner 5 can be placed in the middle. The positioner 5 is designed as a downward convex structure, which can lift the skin equivalent 3 to keep it in a tight state. The fixed sheet 4 is pressed and fixed with the fixed seat 2 above the receiving pool, thereby fixing the skin equivalent 3.

[0047] The receiving liquid flows out from the receiving liquid storage tank 12, passes through the peristaltic pump 13 to flow at a certain flow rate, which is equivalent to connecting the corresponding components through a pipeline. The receiving liquid flows through the receiving pool 1, and the liquid surface is closely attached to the bottom of the skin equivalent 3. After flowing through the sampling pool 9, it finally returns to the receiving liquid storage tank 12, forming a circulation, thereby simulating the process of human blood circulation.

[0048] When sampling, the sampler with the extraction needle 10 is fixed by the fixing device 11, and the height of the fixing device 11 is adjusted to move the extraction needle 10 up and down for extraction sampling, thereby calculating the data information of the amount of gas, liquid, solid, etc. of different pollution types and concentrations penetrating through the skin equivalent into the receiving liquid.

[0049] The structure of the positioner is shown in Figs. 2 and 3. The downward convex structure includes a first convex body 501 and a second convex body 502. At least two groups of telescopic rods 503 are arranged on the first convex body 501, and elastic protruding parts 504 are arranged on one end of the telescopic rods 503. The elastic protruding parts 504 are connected with grooves 5021 in the second convex body 502.

[0050] It should be noted that the telescopic rods 503 drive the elastic protruding parts 504 to connect with the grooves 5021 in the second convex body 502, thereby adjusting the tightness of the skin equivalent 3, and measuring the tightness of the skin in different age groups, thereby improving the accuracy of the experiment. The elastic protruding parts 504 are made of elastic material, such as rubber.

[0051] It should be noted that the three-phase transdermal diffusion device for simulating the penetration of pollutants through the skin into the human body can analyze the amount of drug penetrating through the skin for solid, liquid and gaseous objects, so as to explore the amount of each pollutant type and concentration information penetrating through the skin under each skin tension state, thereby improving the accuracy of the experiment. On the other hand, the device is provided with a circulation system, which can perform multiple sampling through the circulation system, thereby performing multiple analysis on the sampled data, and improving the accuracy of the experiment.

[0052] The second aspect of the present application provides a data analysis method of a three-phase transdermal diffusion device for simulating the penetration of pollutants through the skin into the human body, which is applied to any of the three-phase transdermal diffusion devices for simulating the penetration of pollutants through the skin into the human body, and comprises the following steps:

[0053] S102: obtaining the penetration amount data information of each pollutant information under each tension state through the three-phase transdermal diffusion device for simulating the penetration of pollutants through the skin into the human body, and constructing a pollutant penetration amount data prediction model according to the penetration amount data information of each pollutant information under each tension state;

[0054] S104: obtaining the pollutant type and concentration information of the target area, and inputting the pollutant type and concentration information of the target area into the pollutant penetration amount data prediction model to obtain the penetration amount data information of each pollutant type of the target area under each tension state;

[0055] S106: presetting a penetration amount data threshold, and identifying an abnormal target area and a candidate target area according to the penetration amount data information of each pollutant type of the target area under each tension state and the penetration amount data threshold, and performing pollutant tracing on the abnormal target area;

[0056] It should be noted that when the penetration amount data information of each pollutant type of the target area under each tension state is greater than the penetration amount data threshold, the target area is an abnormal target area, otherwise it is a candidate target area.

[0057] S108: obtaining the penetration amount data information of each pollutant type of the candidate target area, and generating related planning information according to the penetration amount data information of each pollutant type of the candidate target area, and pushing the related planning information in a preset manner.

[0058] It should be noted that in the present embodiment, since the skin tightness state (tightness degree) of users in different age groups is inconsistent, the present method can accurately predict the penetration amount data information of each pollutant type in different age groups, so as to select the optimal activity area. The pollution information includes pollution type and pollution concentration corresponding to the pollution type.

[0059] Further, in the data analysis method of the three-phase transdermal diffusion device for simulating the penetration of pollutants through the skin into the human body, a pollutant penetration amount data prediction model is constructed according to the penetration amount data information of each pollutant information under each tightness state, specifically comprising:

[0060] S202: Construct a graph neural network, and input the penetration amount data information of each pollutant information under each tightness state into the graph neural network, take the tightness state as the first graph node of the graph neural network, take the pollutant information as the second graph node of the graph neural network, and take the penetration amount data as the third graph node of the graph neural network;

[0061] S204: Construct a directed edge connection relationship, and construct a topological structure graph according to the first graph node, the second graph node and the third graph node according to the directed edge connection relationship, obtain a plurality of topological structure graphs, and introduce a Chebyshev distance measurement algorithm to calculate the Chebyshev distance between the second graph nodes in the topological structure graph;

[0062] S206: Obtain the topological structure graph corresponding to the second graph node whose Chebyshev distance is not greater than a preset Chebyshev distance threshold, associate and expand the second graph node, generate an expanded second graph node, and update the topological structure graph according to the expanded second graph node, and obtain an updated topological structure graph;

[0063] S208: Construct a pollutant penetration amount data prediction model based on a deep neural network, input the updated topological structure graph into the pollutant penetration amount data prediction model for coding learning, and output the pollutant penetration amount data prediction model when the loss function of the pollutant penetration amount data prediction model converges to a preset value.

[0064] It should be noted that since there are various descriptions of chemical substances, such as sodium hydroxide, also known as fire alkali, and sodium carbonate, also known as soda, the system does not know the relationship between sodium carbonate and soda. The Chebyshev distance measurement algorithm can calculate the Chebyshev distance between the two, and when the Chebyshev distance is not greater than a preset Chebyshev distance threshold, it indicates that there is a certain relationship between the two, and the second graph node is associated and expanded, thereby optimizing the topological structure graph, not only reducing the number of training in the data set, but also improving the recognition accuracy of the pollutant penetration amount data.

[0065] Further, in the data analysis method of the three-phase transdermal diffusion device for simulating the entry of pollutants into the human body through the skin, the planning information related to the target area is generated according to the permeation amount data information of each pollutant type in the candidate target area, and specifically includes:

[0066] The big data network is constructed, the tightness state information of the skin under each age group is obtained through the big data network, and the permeation amount data information of each pollutant type in the target area for each age group is obtained according to the tightness state information of the skin under each age group and the permeation amount data information of each pollutant type in the candidate target area;

[0067] When the permeation amount data information of each pollutant type in the target area for one of the age groups is greater than the permeation amount data threshold, the corresponding age group is taken as a warning age group of the target area;

[0068] When the permeation amount data information of each pollutant type in the target area for one of the age groups is not greater than the permeation amount data threshold, the corresponding age group is taken as a normal age group of the target area;

[0069] When there is data of the warning age group in the target area, the corresponding target area is set as a warning area, and when there is no data of the warning age group in the target area, the corresponding target area is set as a normally active area, and the planning information related to the warning area and the normally active area is generated.

[0070] It should be noted that the skin tightness (tightness state) of users is inconsistent due to different age groups, and the related age group with hazards in the target area can be warned through the method, thereby protecting the health of the users.

[0071] In addition, the method can further include the following steps:

[0072] A local area network is constructed in the target area, the basic information of the user is accepted by the intelligent terminal, the basic information of the user is transmitted to the local area network, and the basic information of the user in each target area is obtained through the local area network;

[0073] The disease data information of the user within a preset time is obtained according to the basic information of the user in the target area, and the pollution information associated with the disease data information is obtained through big data retrieval according to the disease data information of the user within the preset time;

[0074] The pollution information in the target area is obtained, the Euclidean distance value between the pollution information associated with the disease data information and the pollution information in the target area is calculated, and it is judged whether the Euclidean distance value is greater than a preset Euclidean distance value;

[0075] When the Euclidean distance value is greater than a preset Euclidean distance value, the corresponding target region is marked as a dangerous region, a warning information is generated, the warning information is sent to an intelligent terminal, and related planning information is optimized.

[0076] It should be noted that the intelligent terminal includes a smart phone, a smart watch and the like, and since the related pollution type is closely related to the disease of the user, for example, a skin disease causes the skin firmness of the user to decrease, so that the related pollution type intensifies into the skin tissue, the normal activity area can be further optimized through the method, and the health of the user is further ensured.

[0077] In addition, the method can further include the following steps:

[0078] Meteorological feature data information in a target region and region position information of a current pollution air type are acquired, and a pollution space distribution map is constructed according to the region position information of the current pollution air type;

[0079] Wind direction feature data information is extracted according to the meteorological feature data information in the target region, and a trend of the pollution space distribution map within a preset time is predicted based on the wind direction feature data information,

[0080] Through the prediction, an updated pollution space distribution map within the preset time is acquired, a warning region and a normal activity region in the target region are acquired, and penetration amount data information of each pollution type in each age group corresponding to pollution information in the updated pollution space distribution map within the preset time is calculated;

[0081] The warning region and the normal activity region in the target region are updated according to the penetration amount data information of each pollution type in each age group corresponding to the pollution information in the updated pollution space distribution map within the preset time.

[0082] It should be noted that since the region position of the pollution air type is not constant and is easily affected by the wind direction, the warning region and the normal activity region can be further optimized through the method, and the health of the user is further ensured.

[0083] In addition, it should be understood that although the present specification is described in terms of embodiments, not every embodiment contains only one independent technical solution, and the description of the specification is only for the sake of clarity, and those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can be combined appropriately to form other embodiments that can be understood by those skilled in the art.

[0084] The above is based on the ideal embodiment of the application, through the above description, relevant personnel can make various changes and modifications without deviating from the technical idea of the application. The technical scope of the application is not limited to the content of the specification, and must be determined by the scope of the claims.

Claims

1. A three phase in-vivo skin permeation device for simulating the passage of a contaminant through the skin into the human body, characterised in that, The three-phase transdermal diffusion device for simulating the penetration of pollutants into the human body through the skin comprises the following components: a skin equivalent for simulating the skin tissue of the human body; a circulatory system for simulating the blood circulation process of the human body; a supply chamber for supplying pollutants of a preset type; a sealing cover cooperated with the top of the supply chamber; a positioner connected with the supply chamber, the positioner being a downward protruding structure, the positioner lifting the skin equivalent so that the skin equivalent is kept in a taut state; a receiving pool for receiving substances passing through the skin equivalent and entering the circulatory system.

2. A three phase transdermal diffusion device for simulating the entry of a contaminant into the human body through the skin according to claim 1, wherein, The positioner is further connected with a fixing sheet, and the fixing sheet is a hollow structure in which the positioner is placed.

3. A three phase in-vivo skin diffusion device for simulating the entry of a contaminant into the human body according to claim 2, wherein, The fixing sheet is press-fitted with a fixer and press-fitted with the skin equivalent through the fixing sheet.

4. The three phase transdermal diffusion device for simulating the entry of a contaminant into the human body through the skin according to claim 1, wherein, Air inlets are formed on both sides of the supply chamber, and air ducts are connected with the air inlets.

5. A three phase transdermal diffusion device for simulating the entry of a contaminant into the human body through the skin according to claim 1, wherein, The circulatory system comprises a receiving liquid storage tank and a peristaltic pump, the receiving liquid in the receiving liquid storage tank flows at a preset flow rate through the action of the peristaltic pump, the receiving liquid flows through the receiving pool, and the liquid surface is closely attached to the lower end of the skin equivalent.

6. A three phase transdermal diffusion device for simulating the entry of a contaminant into the human body through the skin according to claim 1, wherein, The three-phase transdermal diffusion device further comprises a sampling pool connected with the circulatory system and a fixing device on which an extraction needle and an adjusting fixing device are installed.

7. A three phase transdermal diffusion device for simulating the entry of a contaminant into the human body through the skin according to claim 1, wherein, The downward protruding structure comprises a first protruding body and a second protruding body, at least two groups of telescopic rods are arranged on the first protruding body, an elastic protruding part is arranged on one end of the telescopic rod, and the elastic protruding part is connected with a groove in the second protruding body.

8. A method of data analysis for a three-phase transdermal diffusion device that simulates the entry of a contaminant into the human body through the skin, characterized by, The three-phase transdermal diffusion device for simulating the penetration of pollutants into the human body through the skin according to any one of claims 1-7 comprises the following steps: Obtain the permeation amount data information of each pollutant information under each taut state through the three-phase transdermal diffusion device for simulating the penetration of pollutants into the human body through the skin, and construct a pollutant permeation amount data prediction model according to the permeation amount data information of each pollutant information under each taut state; Obtain the type and concentration information of the pollutants in the target area, and input the type and concentration information of the pollutants in the target area into the pollutant permeation amount data prediction model to obtain the permeation amount data information of each pollutant type in the target area under each taut state; Set a permeation amount data threshold, and identify abnormal target areas and candidate target areas according to the permeation amount data information of each pollutant type in the target area under each taut state and the permeation amount data threshold, and perform pollutant tracing on the abnormal target areas; Obtain the permeation amount data information of each pollutant type of the candidate target area, and generate related planning information according to the permeation amount data information of each pollutant type of the candidate target area, and push the related planning information in a preset manner.

9. The data analysis method for a three-phase transdermal diffusion device simulating pollutants entering the human body through the skin, as described in claim 8, is characterized in that... The pollutant permeation amount data prediction model is constructed according to the permeation amount data information of each pollutant information under each taut state, and specifically comprises: The graph neural network is constructed, and the transmittance data information of each pollutant information under each tight state is input into the graph neural network. The tight state is taken as a first graph node of the graph neural network, the pollutant information is taken as a second graph node of the graph neural network, and the transmittance data is taken as a third graph node of the graph neural network. A directed edge connection relationship is constructed, and the first graph node, the second graph node and the third graph node are constructed into a topological structure graph according to the directed edge connection relationship. A plurality of topological structure graphs are obtained, and a Chebyshev distance measurement algorithm is introduced to calculate the Chebyshev distance between the second graph nodes in the topological structure graph. The topological structure graph corresponding to the second graph node with the Chebyshev distance not greater than a preset Chebyshev distance threshold value is obtained, the second graph node is associated and expanded to generate an expanded second graph node, and the topological structure graph is updated according to the expanded second graph node to obtain an updated topological structure graph. A pollutant transmittance data prediction model is constructed based on a deep neural network, the updated topological structure graph is input into the pollutant transmittance data prediction model for coding learning, and when the loss function of the pollutant transmittance data prediction model converges to a preset value, the pollutant transmittance data prediction model is output.

10. The method of claim 8, wherein the three-phase transdermal diffusion device is an analog of a pollutant penetrating into the human body through the skin. The planning information related to the transmittance data information of each pollutant type of the candidate target region is generated, specifically including: A big data network is constructed, and the tight state information of the skin under each age group is obtained through the big data network. The transmittance data information of each pollutant type in the target region for each age group is obtained according to the tight state information of the skin under each age group and the transmittance data information of each pollutant type of the candidate target region. When the transmittance data information of each pollutant type in the target region for one of the age groups is greater than the transmittance data threshold value, the corresponding age group is taken as a warning age group of the target region. When the transmittance data information of each pollutant type in the target region for one of the age groups is not greater than the transmittance data threshold value, the corresponding age group is taken as a normal age group of the target region. When there is data of the warning age group in the target region, the corresponding target region is set as a warning region, and when there is no data of the warning age group in the target region, the corresponding target region is set as a normally active region. The planning information related to the warning region and the normally active region is generated.

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