Insecticidal composition containing 4-(trifluoromethyl)nicotinamide, and application thereof

Abstract

The present invention belongs to the technical field of pesticides, and specifically relates to an insecticidal composition containing 4-(trifluoromethyl)nicotinamide, and an application thereof. The insecticidal composition includes an active ingredient A and an active ingredient B, wherein the active ingredient A is 4-(trifluoromethyl)nicotinamide, and the active ingredient B is selected from one or more of the following compounds: afidopyropen, formula (I), dimpropyridaz, formula (II), isoflualanam, fipronil, imidacloprid, thiamethoxam, avermectin, acephate and beta-cypermethrin. The composition has features such as reasonable components, good insecticidal effect, low administration cost, reduced application amount, crop safety, and reduced residue.

Description

Insecticidal composition containing 4-trifluoromethylnicotinamide and application thereof TECHNICAL FIELD

[0001] The present application belongs to the technical field of pesticides, and particularly relates to an insecticidal composition containing 4-trifluoromethylnicotinamide and application thereof. BACKGROUND

[0002] In the process of agricultural production, the control of various types of harmful insects mainly relies on the application of a large number of pesticide products. The large-scale and frequent unreasonable use of pesticides leads to the continuous enhancement of the resistance of harmful insects, the more serious harm to crops, and the more difficult prevention and control. The use of two or more pesticides with different mechanisms can achieve the effects of treating different pests, improving the prevention and control effect, and reducing the resistance of pests. SUMMARY

[0003] The present application provides an insecticidal composition containing 4-trifluoromethylnicotinamide and application thereof. The composition has reasonable components, good insecticidal effect, low drug cost, and the characteristics of reducing the application amount, being safe to crops, and reducing the amount of pesticide residues.

[0004] An insecticidal composition comprising active ingredient A and active ingredient B, wherein,

[0005] The active ingredient A is 4-trifluoromethylnicotinamide (CAS No.: 158062-71-6);

[0006] The active ingredient B is selected from one or more of the following compounds: benclothiaz (CAS No.: 915972-17-7), flufenprox (CAS No.: 1403615-77-9), sulfoxaflor (CAS No.: 2892524-05-7), fipronil (CAS No.: 120068-37-3), imidacloprid (CAS No.: 138261-41-3), thiamethoxam (CAS No.: 153719-23-4), abamectin (CAS No.: 71751-41-2), acephate (CAS No.: 30560-19-1), and lambda-cyhalothrin (CAS No.: 65731-84-2).

[0007] In one specific embodiment, the weight ratio of A and B is 1:20-50:1, 1:10-20:1, 1:5-8:1, 2:5-20:3, 1:2-5:1, 2:3-4:1, 1:1-10:3, or 2:1-5:2.

[0008] The present application also discloses the application of the insecticidal composition in the prevention and control of plant pests in agriculture, forestry, and horticulture.

[0009] According to one aspect of the present application, the composition can be used not only for the control of hemipteran pests, but also for the control of a wide range of agricultural and horticultural pests (e.g., insects of the orders Coleoptera, Lepidoptera, Thysanoptera, Diptera, etc. or nematodes, harmful mites, etc.). In particular, the following examples can be preferably used for the control of lepidopteran pests.

[0010] Hemipteran pests: Aleyrodidae, Aphididae, or Pseudococcidae (preferably Aleyrodidae); leafhoppers, Aleyrodidae, Pentatomidae, or Coccoidea (Diaspididae, Pseudococcidae, Ortheziidae, Phenacoleidae, Ortheziidae, Lacciferidae, Pseudococcidae, Coccidae, Eriococcidae, Kermesidae, Beesonidae, or Kerrimicococcidae), and Psylloidae; more preferably, Myzus persicae, Aphis glycines, Rhopalosiphum padi, Myzus persicae, Aphis gossypii, Eotetranychus kankitus, Trigonotylus caelestialium, or Ceroplastes floridensis, red banded lice, and citrus psyllids, etc.

[0011] The active ingredients of the composition of the present application can be prepared by known methods, or can be purchased as commercially available formulations. These compounds are mixed with a surfactant and, if necessary, an auxiliary agent, in an appropriate ratio, dissolved, separated, suspended, mixed, impregnated, adsorbed, or adhered to an appropriate inert carrier, and used as various formulations, such as a suspension, an emulsion suspension, an emulsion, a liquid, a wettable powder, a wettable granule, a granule, a powder, a microcapsule, a capsule, a tablet, a large granule, or a bag, etc.

[0012] The mass percentage of A and B in the insecticidal composition is 1 to 95% of the total amount, preferably 5 to 80%. Generally, the insecticidal composition of the present application contains 1 to 95 parts by weight of the active ingredient and 5 to 99 parts by weight of the conventional agricultural auxiliary agent.

[0013] Each of the active ingredients can be used directly using a commercially available formulation, or the active ingredients can be formulated separately from each other or together and used. When formulated, the active ingredients are dissolved, separated, suspended, mixed, impregnated, adsorbed, or adhered to an appropriate inert carrier, or, if necessary, the active ingredients are dissolved, separated, suspended, mixed, impregnated, adsorbed, or adhered to an appropriate inert carrier, together with an auxiliary agent, in an appropriate ratio, and used as an appropriate formulation, such as a suspension (flowable), an emulsion suspension, an emulsion, a liquid, a wettable powder, a wettable granule, a granule, a powder, a microcapsule, a capsule, a tablet, a large granule, or a bag, etc.

[0014] As the above-mentioned inert carrier, solid carriers and liquid carriers can be exemplified, and as the solid carrier, for example, natural mineral-based substances such as quartz, clay, kaolin, pyrophyllite, sericite, talc, bentonite, acid clay, attapulgite, zeolite, diatomite, and the like; inorganic salts such as calcium carbonate, ammonium sulfate, sodium sulfate, potassium chloride, and the like; synthetic silicic acid, synthetic silicates, starch, cellulose, plant powders (for example, sawdust, coconut shells, corn cob cores, tobacco stems, and the like); plastic carriers such as polyethylene, polypropylene, polyvinylidene chloride, and the like; urea; inorganic hollow bodies; plastic hollow bodies; fumed silica (white carbon), and the like can be exemplified. These can be used alone, and two or more kinds can also be used in combination. As the liquid carrier, for example, monohydric alcohols such as methanol, ethanol, propanol, isopropanol, butanol, and the like; polyhydric alcohols such as ethylene glycol, diethylene glycol, propylene glycol, hexylene glycol, polyethylene glycol, polypropylene glycol, glycerol, and the like; polyhydric alcohol compounds such as propylene glycol ethers; ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone, diisobutyl ketone, cyclohexanone, and the like; ethers such as diethyl ether, dioxane, ethylene glycol monoethyl ether, dipropyl ether, tetrahydrofuran, and the like; aliphatic hydrocarbons such as n-paraffins, cycloparaffins, isoparaffins, kerosene, mineral oil, and the like; aromatic hydrocarbons such as benzene, toluene, xylene, solvent naphtha, alkyl naphthalenes, and the like; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, and the like; esters such as ethyl acetate, diisopropyl phthalate, dibutyl phthalate, dioctyl phthalate, dimethyl adipate, and the like; lactones such as γ-butyrolactone, and the like; amides such as dimethylformamide, diethylformamide, dimethylacetamide, N-alkylpyrrolidones (N-methylpyrrolidone, and the like); nitriles such as acetonitrile, and the like; sulfur compounds such as dimethyl sulfoxide, and the like; vegetable oils such as soybean oil, rapeseed oil, cottonseed oil, castor oil, and the like; and water, and the like can be exemplified. These can be used alone, and two or more kinds can also be used in combination.

[0015] As the adjuvant, surfactants used as dispersants / wetting agents / spreading agents / anti-foaming agents, and the like, binders, tackifiers, thickeners, colorants, anti-freezing agents, anti-caking agents, disintegrants, and anti-decomposition agents, and the like can be exemplified. In addition to these, preservatives, plant sheets can be used as the additive ingredients as needed. These additive ingredients can be used alone, and two or more kinds can also be used in combination.

[0016] As the surfactant used as a dispersant / wetting agent / extender / spreading agent, etc., for example, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, sucrose fatty acid ester, polyoxyethylene fatty acid ester, polyoxyethylene resin acid ester, polyoxyethylene fatty acid diester, polyoxyethylene alkyl ether, polyoxyethylene alkyl aryl ether, polyoxyethylene alkyl phenyl ether, polyoxyethylene dialkyl phenyl ether, polyoxyethylene alkyl phenyl ether formalin condensate, polyoxyethylene polyoxypropylene block copolymer, polystyrene polyoxyethylene block polymer, alkyl polyoxyethylene polypropylene block copolymer ether, polyoxyethylene alkyl amine, polyoxyethylene fatty acid amide, polyoxyethylene fatty acid diphenyl ether, polyalkylene benzyl phenyl ether, polyalkylene oxide styryl phenyl ether, acetylene glycol, polyoxyalkylene addition acetylene glycol, polyoxyethylene ether type polysiloxane, ester type polysiloxane, fluorine-based surfactant, polyoxyethylene castor oil, polyoxyethylene hardened castor oil, and the like nonionic surfactants; alkyl sulfate, polyoxyethylene alkyl ether sulfate, polyoxyethylene alkyl phenyl ether sulfate, polyoxyethylene styryl phenyl ether sulfate, alkyl benzene sulfonate, alkyl aryl sulfonate, lignin sulfonate, alkyl sulfosuccinate, naphthalene sulfonate, alkyl naphthalene sulfonate, salt of formalin condensate of naphthalene sulfonate, salt of formalin condensate of alkyl naphthalene sulfonate, fatty acid salt, polycarboxylic acid salt, polyacrylic acid salt, N-methyl-fatty acid sarcosin ester, resin acid salt, polyoxyethylene alkyl ether phosphate, polyoxyethylene alkyl phenyl ether phosphate, and the like anionic surfactants; dodecylamine hydrochloride, stearylamine hydrochloride, oleylamine hydrochloride, stearylamine acetate, octadecylaminopropylamine acetate, alkyl trimethylammonium chloride, alkyl dimethyl benzyl ammonium chloride, and the like alkyl amine salts, and the like cationic surfactants; amino acid type or betaine type and the like amphoteric surfactants, and the like. These surfactants can be used alone, and two or more can be used in combination.

[0017] As the adhesive or tackifier, for example, carboxymethyl cellulose and its salts, dextrin, water-soluble starch, xanthan gum, guar gum, sucrose, polyvinyl pyrrolidone, gum arabic, polyvinyl alcohol, polyvinyl acetate, sodium polyacrylate, polyethylene glycol having an average molecular weight of 6000 to 20000, polyethylene oxide having an average molecular weight of 1 million to 5 million, phospholipid (e.g., cephalin, lecithin, and the like), cellulose powder, dextrin, processed starch, polyamino carboxylic acid chelate compound, crosslinked polyvinyl pyrrolidone, copolymer of maleic acid and styrene, (meth)acrylic acid-based copolymer, half ester of polymer formed from polyhydric alcohol and diacid anhydride, water-soluble salt of polystyrene sulfonic acid, paraffin, terpene, polyamide resin, polyacrylic acid salt, polyoxyethylene, wax, polyvinyl alkyl ether, alkyl phenol formalin condensate, synthetic resin emulsion, and the like can be listed.

[0018] As the thickening agent, for example, water-soluble polymers such as xanthan gum, guar gum, diutan gum, carboxymethyl cellulose, polyvinylpyrrolidone, carboxyvinyl polymer, acrylic polymer, starch derivatives, polysaccharides, and the like; inorganic micropowders such as high-purity bentonite, fumed silica (white carbon), and the like can be exemplified.

[0019] As the coloring agent, for example, inorganic pigments such as iron oxide, titanium oxide, Prussian blue, and the like; organic dyes such as alizarin dye, azo dye, metal phthalocyanine dye, and the like can be exemplified.

[0020] As the antifreezing agent, for example, polyhydric alcohols such as ethylene glycol, diethylene glycol, propylene glycol, glycerin, and the like can be exemplified.

[0021] As the anti-caking or disintegration-promoting aid, for example, polysaccharides such as starch, alginic acid, mannose, galactose, and the like; polyvinylpyrrolidone; fumed silica (white carbon); ester gum; petroleum resin; sodium tripolyphosphate; sodium hexametaphosphate; metal stearate; cellulose powder; dextrin; copolymer of methacrylate; polyvinylpyrrolidone; polyamino carboxylic acid chelate compound; sulfonated styrene-isobutylene-maleic anhydride copolymer; starch-polyacrylonitrile graft copolymer, and the like can be exemplified.

[0022] As the decomposition-preventing agent, for example, desiccants such as zeolite, quicklime, magnesium oxide, and the like; antioxidants such as phenol compounds, amine compounds, sulfur compounds, phosphoric acid compounds, and the like; ultraviolet absorbers such as salicylic acid compounds, benzophenone compounds, and the like can be exemplified. As the preservative, for example, potassium sorbate, 1,2-benzothiazolin-3-one, and the like can be exemplified.

[0023] Further, as needed, functional spreading agents, metabolic decomposition inhibitors such as piperonyl butoxide, and the like; antioxidants such as BHT; ultraviolet absorbers; and other aids can also be used.

[0024] The "crop" to which the pesticidal composition of the present application can be used is not particularly limited, and also includes genetically recombined crops (herbicide-resistant crops, pest-resistant crops into which a gene for producing a pesticidal protein is integrated, disease-resistant crops into which a gene for an inducer of disease resistance is integrated, crops with improved taste, crops with improved storability, crops with improved yield, and the like) endowed with useful traits by classical breeding methods or advances in genetic recombination techniques in recent years.

[0025] In the use of the insecticidal composition of the present application, an effective amount of the above-mentioned preparation containing each component in advance is directly applied to the insect, or to the target crop where the insect is expected to occur, or to the seed or soil for sowing or a cultivation carrier, etc. in the form of the original state or appropriately diluted with water or the like or suspended, by a usual treatment. As the treatment method, for example, the following can be mentioned: a scattering treatment to stems and leaves, a rice seedling box treatment, a seed treatment such as seed dressing / seed soaking / seed disinfection, a planting hole treatment, a root treatment, a furrow treatment, a drenching treatment, a soil mixing treatment, and the like, and the hydroponic solution in hydroponic culture can also be treated.

[0026] In the case of using the insecticidal composition of the present application, in order to prevent the simultaneous occurrence of disease insects and weeds, etc., to enhance the effect, to reduce the phytotoxicity of the crop, an agricultural and horticultural fungicide, an agricultural and horticultural insecticide, an agricultural and horticultural herbicide, a synergist, a safener, and the like can be simultaneously used.

[0027] Advantages of the present application:

[0028] 1) The components of the present application are reasonable, the insecticidal effect is good, the cost of using the drug is low, the insecticidal activity is not a single superposition of the active ingredients, but has a significant synergistic effect, can delay the development of target pests resistance, is safe to crops, and meets the safety requirements of pesticide formulations.

[0029] 2) The composition of the present application is safe to non-target organisms and natural enemies, and can effectively reduce the use dose of the pesticide and reduce the pesticide residue on agricultural products. DETAILED DESCRIPTION

[0030] In order to make the purpose, technical scheme and advantages of the present application more concise and clear, the present application is described by the following specific examples, but the present application is not limited to these examples only. The examples described below are only better embodiments of the present application, which can be used to describe the present application, and cannot be understood as limiting the scope of the present application. It should be noted that any modification, equivalent replacement and improvement made within the spirit and principles of the present application should be included in the protection scope of the present application.

[0031] Composition insecticide activity determination test:

[0032] (1) Test conditions and operation steps

[0033] The test insect is the peach aphid: radish seedlings are planted in disposable plastic cups, 3-4 seedlings are planted in each cup, the radish seedlings are planted to 5-6 cm, and the aphids are planted after 2-3 days, and the test is carried out when the number of aphids reaches a certain scale.

[0034] The test insect is Sitobion miscanthi: wheat seedlings are planted in disposable plastic cups, 5-6 seedlings per cup, and the insects are introduced when the wheat seedlings grow to 5-6 cm, and the test is performed after 2-3 days when the number of aphids reaches a certain scale.

[0035] The test insect is Aphis craccivora: broad bean seedlings are planted in disposable plastic cups, 1 seedling per cup, and the insects are introduced when the broad bean seedlings grow to 5-6 cm, and the test is performed after 2-3 days when the number of aphids reaches a certain scale.

[0036] The active ingredient is dissolved in acetone, and the solution is diluted with distilled water to gradient doses. A small spray bottle is used for spraying treatment, (6-9) times per plant, and the spraying is performed until the front and back of the leaves are wet but no liquid is dropped. The process is repeated 3 times, and the highest dose containing acetone is used as a control. After the spraying is completed, the plants are placed in a treatment room (temperature 25°C, humidity 60%). The number of dead insects is investigated after 48 hours, and the mortality rate is calculated. Mortality rate = (number of dead insects / number of test insects) x 100%.

[0037] (2) Synergistic qualitative evaluation

[0038] Within the selected ratio range, different ratios are set for toxicity determination, and the best ratio is selected according to the synergistic effect. When the synergistic effect is > 0, it indicates that there is a synergistic effect; when the synergistic effect is close to 0, it indicates that there is an additive effect; when the synergistic effect is < 0, it indicates that there is an antagonistic effect. Synergistic effect = actual mortality rate - theoretical mortality rate Theoretical mortality rate = 1-(1-P1)(1-P2)

[0039] In the formula, P1, P2 - the mortality rate of each single agent in the mixture.

[0040] Table 1 Synergistic qualitative evaluation test results of the composition

[0041] Although the present application has been described in detail in the foregoing general description and specific embodiments, modifications and improvements thereto will occur to those skilled in the art. Therefore, it is to be understood that the present application is to be limited only by the scope of the appended claims.

Claims

1. An insecticidal composition, characterized by, The insecticidal composition comprises active ingredient A and active ingredient B, wherein active ingredient A is 4-trifluoromethylnicotinamide; active ingredient B is selected from one or more of the following compounds: bifenazate, flupyradifurone, sulfoxaflor, fipronil, imidacloprid, thiamethoxam, abamectin, acephate and lambda cyhalothrin.

2. The insecticidal composition according to claim 1, characterized by, The weight ratio of the active ingredient A and the active ingredient B is 1:20-50:1, 1:10-20:1, 1:5-8:1, 2:5-20:3, 1:2-5:1, 2:3-4:1, 1:1-10:3 or 2:1-5:

2.

3. The insecticidal composition according to claim 1, wherein The mass percentage of the active ingredient A and the active ingredient B is 1-95% of the total amount, preferably 5-80%.

4. The insecticidal composition according to claim 1, wherein The insecticidal composition further comprises one or more of conventional adjuvants, preferably one or more of surfactants, binders, tackifiers, thickeners, colorants, antifreezing agents, anticaking agents, disintegrants and decomposition-preventing agents.

5. The insecticidal composition according to claim 1, wherein The specific formulation of the insecticidal composition is suspension concentrate, emulsion suspension concentrate, emulsion, liquid, wettable powder, wettable granule, granule, powder, microcapsule, capsule, tablet, macrogranule or bag.

6. Use of the insecticidal composition according to any one of claims 1-5 for preventing or controlling harmful organisms that attack crops or crop propagation materials.

7. Use according to claim 6, characterized in that, The harmful organisms are Lepidoptera pests.

8. A method of preventing or controlling a pest, characterized by, The insecticidal composition according to any one of claims 1-5 is used for the target harmful organisms and / or their environment.

9. A method for preventing or controlling a pest, characterized by, The insecticidal composition according to any one of claims 1-5 is applied to seeds, target crops, soil where target crops grow or soil suitable for target crops to grow.

10. A method of protecting a target crop from attack by pests, characterised in that, The insecticidal composition according to any one of claims 1-5 is contacted with target crops, target harmful organisms and / or their environment, propagation materials of target crops.

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