Device for transporting an organ or tissue

Abstract

A device for transporting an organ or tissue. The device comprises a container for containing the organ or tissue and a pneumatic pump for pumping a perfusion fluid in order circulating the perfusion fluid through the organ or tissue. The device comprises a holder for holding at least one gas vessel comprising pressurised gas. The pressurised gas is used to create a pulsating gas flow to the pump for pumping the perfusion fluid.

Description

[0001] P36993PC00

[0002] Title: Device for transporting an organ or tissue

[0003] FIELD OF THE INVENTION

[0004] The invention relates to a device for transporting an organ or tissue. The device comprises a container for containing the organ or tissue and a pneumatic pump for pumping a perfusion fluid in order circulating the perfusion fluid through the organ or tissue. The device comprises a holder for holding at least one gas vessel comprising pressurised gas. The pressurised gas is used to create a pulsating gas flow to the pump for pumping the perfusion fluid.

[0005] BACKGROUND OF THE INVENTION

[0006] Perfusion of an organ or tissue, particularly a donor organ or tissue, with a perfusion fluid during the transport phase improves the quality of the organ or tissue available for the donor. This reduces the risk of the recipient's body rejecting the organ or tissue, thereby reducing the amount of anti-rejection medication required for the patient. This is not only important for the patient's health, but also for society, as there is a worldwide shortage of donor organs or tissues.

[0007] The known devices have the disadvantage that the circulation of the perfusion fluid is not sufficiently controlled during the transport phase. As a result, there is a relatively high risk that the quality of the organ or tissue is reduced during transport.

[0008] SUMMARY OF THE INVENTION

[0009] The invention has the objective to provide an improved, or at least alternative, device for transporting an organ or tissue. This objective is achieved by a device for transporting an organ or tissue, comprising:

[0010] - a container for containing the organ or tissue,

[0011] - at least one pneumatic pump configured to pump a perfusion fluid,

[0012] - container conduits connected to the at least one pump for circulating the perfusion fluid through the container,

[0013] - a holder for holding at least one gas vessel comprising pressurised gas,

[0014] - at least one vessel conduit for in use connecting the at least one gas vessel to the at least one pump,

[0015] - at least one valve provided at the at least one vessel conduit,

[0016] - a control system configured to control the at least one valve for providing a pulsating gas flow to the at least one pump for pumping the perfusion fluid, which control system is operatively coupled to the at least one valve,

[0017] - a temperature sensor system configured to in use acquire temperature condition data relating the perfusion fluid and / or relating the organ or tissue, which temperature sensor system is operatively coupled to the control system, and wherein

[0018] -- the control system is configured to control the at least one valve in order to adjust a perfusion pressure of the perfusion fluid circulated by the at least one pump on basis of the temperature condition data as received from the temperature sensor system.

[0019] As a result of this the control system automatically adapts the perfusion pressure of the perfusion fluid to the temperature of the perfusion fluid and / or of the organ or tissue. Said temperature changes over time, for example because measures to keep the organ or tissue cool during transport get exhausted. The invention is based on the insight that if the temperature of the organ or tissue increases, the resistance within the organ or tissue decreases and higher pressures are required to achieve the psychological liquid pressures, flows, and oxygen supply to maintain or restore organ or tissue function and prevent organ or tissue damage.

[0020] In an embodiment of the device according to the invention, the control system is configured to determine a preferred pressure value for the perfusion fluid circulated by the at least one pump.

[0021] In an embodiment of the device according to the invention, the control system is configured to generate at least one control command based on said preferred pressure value and the at least one valve is configured to actuate according to the at least one control command to circulate the perfusion fluid via the at least one pump at the preferred pressure value.

[0022] In an embodiment of the device according to the invention, the control system is configured to perform at least one calculation on the temperature condition data and / or at least one comparison of the temperature condition data with a database comprising predetermined pressure values for predetermined temperature condition data in order to determine the preferred pressure value.

[0023] In an embodiment of the device according to the invention, the control system is configured to generate the at least one control command on basis of said at least one calculation and / or said at least one comparison.

[0024] In an embodiment of the device according to the invention, the temperature sensor system comprises at least one temperature sensor provided at the container conduits and / or the container.

[0025] In an embodiment of the device according to the invention, the device comprises a pressure sensor system configured to in use acquire pressure condition data relating the perfusion fluid, which pressure sensor system is operatively coupled to the control system, and the control system is configured to control the at least one valve for adjusting the perfusion pressure of the perfusion fluid circulated by the at least one pump on basis of the pressure condition data as received from the pressure sensor system.

[0026] In an embodiment of the device according to the invention, the control system is configured to determine if a present pressure value of the perfusion fluid circulated by the at least one pump equals the preferred pressure value.

[0027] In an embodiment of the device according to the invention, the pressure sensor system comprises at least one pressure sensor being in fluid communication with the container conduits and / or the container.

[0028] In an embodiment of the device according to the invention, the control system is configured to increase the perfusion pressure of the perfusion fluid circulated by the at least one pump when the temperature condition data indicate that a temperature of the perfusion fluid and / or of the organ or tissue increases.

[0029] In an embodiment of the device according to the invention, the control system is configured to decrease the perfusion pressure of the perfusion fluid circulated by the at least one pump when the temperature condition data indicate that a temperature of the perfusion fluid and / or the organ or tissue creases.

[0030] In an embodiment of the device according to the invention, the control system is configured to increase the perfusion pressure of the perfusion fluid linearly or non-linearly with respect to the increase of the temperature of the perfusion fluid and / or the organ or tissue indicated by the temperature condition data.

[0031] In an embodiment of the device according to the invention, the control system is configured to decrease the perfusion pressure of the perfusion fluid linearly or non-linearly with respect to the decrease of the temperature of the perfusion fluid and / or the organ or tissue indicated by the temperature condition data.

[0032] In an embodiment of the device according to the invention, the control system is configured to operate the at least one pump:

[0033] - in a first operation mode, wherein the perfusion pressure of the circulated perfusion fluid is a low perfusion pressure, when the temperature of the perfusion fluid and / or of the organ or tissue indicated by the temperature condition data is a low temperature,

[0034] - in a second operation mode, wherein the perfusion pressure of the circulated perfusion fluid is an intermediate perfusion pressure, when the temperature of the perfusion fluid and / or of the organ or tissue indicated by the temperature condition data is an intermediate temperature, which intermediate perfusion pressure is higher than the low perfusion pressure, and which intermediate temperature is higher than the low temperature, and - in a third operation mode, wherein the perfusion pressure of the circulated perfusion fluid is a high perfusion pressure, when the temperature of the perfusion fluid and / or of the organ or tissue indicated by the temperature condition data is a high temperature, which high perfusion pressure is higher than the intermediate perfusion pressure, and the high temperature is higher than the intermediate temperature.

[0035] In an embodiment of the device according to the invention, the low temperature is between, and including, 0 - 12 degrees Celsius, or between, and including, 8 - 10 degrees Celsius, the intermediate temperature is between, and including, 12 - 25 degrees Celsius, or between, and including, 20 - 23 degrees Celsius, and the high temperature is between, and including, 25 - 39 degrees Celsius, or between, and including, 35 - 37 degrees Celsius.

[0036] In an embodiment of the device according to the invention, the low perfusion pressure is between, and including, 15 - 35 mmHg, or between, and including, 23 - 30 mmHg, the intermediate perfusion pressure is between, and including, 35 - 65 mmHg, or between, and including, 45 - 60 mmHg, and the high perfusion pressure is between, and including, 65 - 100 mmHg, or between, and including, 70 - 80 mmHg.

[0037] In an embodiment of the device according to the invention, the low perfusion pressure is between, and including, 20 - 47 mbar , or between, and including, 31 - 40 mbar, the intermediate perfusion pressure is between, and including, 47 - 87 mbar, or between, and including, 60 - 80 mbar, and the high perfusion pressure is between, and including, 87 - 133 mbar, or between, and including, 93 - 107 mbar.

[0038] In an embodiment of the device according to the invention, the at least one valve comprises at least one primary valve, and the control system is configured to control via the at least one primary valve a gas frequence of the pulsating gas flow provided to the at least one pump.

[0039] In an embodiment of the device according to the invention, the at least one valve comprises at least one secondary valve, and the control system is configured to control via the at least one secondary valve a gas pressure of the pulsating gas flow provided to the at least one pump.

[0040] It will be clear to the skilled person that any combination of any number of the above identified embodiments of the device according to the invention may be made.

[0041] The invention further relates to a method for transporting an organ or tissue, comprising placing an organ or tissue in a container, closing said container and pumping a perfusion fluid as well as a gas, preferably an oxygen- containing gas, into said container, said pumping of the perfusion fluid being caused by a pulsating gas flow of said gas, wherein the pulsating gas flow is provided to at least one pneumatic pump, and a perfusion pressure of the perfusion fluid circulated by the at least one pump through the container is controlled on basis of temperature condition data relating the perfusion fluid and / or relating the organ or tissue. In an embodiment of the method according to the invention, said method is performed with the device according to the invention.

[0042] It will be clear to the skilled person that the method according to the invention may operate in line with any combination of any number of the above identified embodiments of the device according to the invention.

[0043] BRIEF DESCRIPTION OF THE DRAWINGS

[0044] Embodiments of the device according to the invention and the method according to the invention will be described by way of example only, with reference to the accompanying schematic drawings in which corresponding reference symbols indicate corresponding parts.

[0045] Figure 1 shows a schematical overview of an embodiment of the device and method according to the invention,

[0046] Figure 2 schematically shows a view in perspective of one of the pumps of the device of figure 1 ,

[0047] Figure 3 schematically shows a cross-sectional view the pump of figure 2, and the Figures 4a and 4b schematically show views in perspective of a further embodiment of the device according to the invention.

[0048] DETAILED DESCRIPTION OF THE DRAWINGS

[0049] Figure 1 shows a schematical overview of an embodiment of the device 1 and method according to the invention. The device 1 is configured to transport an organ, such as a liver or a kidney, or tissue. When reference is made to only organs, this applies in a similar manner to tissues. The device 1 comprises a base surface 20, side walls 21 and a cover 22. The device 1 comprises a container 2 for containing the organ or tissue and at least one pneumatic pump 3a-b configured to pump a perfusion fluid 4. The perfusion fluid 4 may be a perfusion liquid and / or a perfusion gas.

[0050] Container conduits 5 are connected to the at least one pump 3 for circulating the perfusion fluid 4 through the container 2. The container conduits 5 are in use connected to the organ or tissue. A first container conduit 5a can be connected to an artery of a liver and a second container conduit 5b can be connected to a vein of a liver which is not an artery. In the situation where the donor organ to be transported is a kidney, only one container conduit 5a-b needs to be used and connected to the artery of the kidney.

[0051] A holder 6 is provided for holding at least one gas vessel 7 comprising pressurised gas. Only one gas vessel 7 is provided in figure 1. The pressurised gas in the gas vessel 7 has a gas pressure of about 5000 mmHg (6666 mbar). The device 1 has at least one vessel conduit 8a-b for in use connecting the at least one gas vessel 7 to the at least one pump 3a-b. At least one valve 9a-b, 11a-b is provided at the at least one vessel conduit 8a-b. A control system 10 is configured to control the at least one valve 9a-b, 11a-b for providing a pulsating gas flow to the at least one pump 3a-b for pumping the perfusion fluid 4. The control system 10 is operatively coupled to the at least one valve 9a-b, 11a-b via an electrical connection as indicated in figure 1. Said electrical connection is used for communication between the control system 10 and the at least one valve 9a-b, 11a-b and for the supply of electrical energy to operate the at least one valve 9a-b, 11a-b.

[0052] A temperature sensor system 18 is configured to in use acquire temperature condition data relating the perfusion fluid 4 and / or relating the organ or tissue. The temperature sensor system 18 is operatively coupled to the control system 10 via an electrical connection. Said electrical connection is used for communication between the control system 10 and the temperature sensor system 18 and for the supply of electrical energy to operate the temperature sensor system 18.

[0053] The control system 10 is configured to control the at least one valve 9a-b, 11a-b in order to adjust a perfusion pressure of the perfusion fluid 4 circulated by the at least one pump 3a-b on basis of the temperature condition data as received from the temperature sensor system 18.

[0054] The control system 10 automatically adapts the perfusion pressure of the perfusion fluid 4 to the temperature of the perfusion fluid 4 and / or of the organ or tissue. Said temperature changes over time, for example because measures provided to keep the organ or tissue cool during transport tend to get exhausted. The invention is based on the insight that if the temperature of the organ or tissue increases, the resistance within the organ or tissue decreases and higher pressures are required to achieve the psychological liquid pressures, flows, and oxygen supply to maintain or restore organ or tissue function and prevent organ or tissue damage.

[0055] The control system 10 is electrically connected to a battery 17 to obtain electrical energy for its operation and for the supply of electrical energy to other electrical units being electrically connected to the control system 10. The electrical connection between said other electronical units may also be used for communication with the control system 10.

[0056] The control system 10 is configured to determine a preferred pressure value for the perfusion fluid 4 circulated by the at least one pump 3a-b. The control system 10 generates at least one control command based on said preferred pressure value and the at least one valve 9a-b, 11a-b actuates according to the at least one control command to circulate the perfusion fluid 4 via the at least one pump 3 at the preferred pressure value.

[0057] The control system 10 performs at least one calculation on the temperature condition data and / or at least one comparison of the temperature condition data with a database 23 comprising predetermined pressure values for predetermined temperature condition data in order to determine the preferred pressure value. The control system 10 generates the at least one control command on basis of said at least one calculation and / or said at least one comparison.

[0058] Table 1

[0059] Table 1 above as an example shows data obtained from experiments carried out with the device 1 according to the invention. The column "Time" indicates the minutes elapsed after the organ, in this case a kidney, was placed in the device 1. The "Temperature" column indicates the temperature measured during the minutes elapsed, as indicated in the same row. The "Preferred pressure" column indicates the preferred perfusion pressure at the temperature indicated in the same row. The preferred pressure values refer to the average pressure in the circulating perfusion fluid and are the result of an extensive R&D project.

[0060] The term perfusion pressure relates to the average perfusion pressure which corresponds with the mean arterial pressure or the mean venous pressure in the fluid conduit to the organ or tissue. The average pressure is defined by the pressure measured at all time points combined during one pumping cycle from which an area under the curve calculation is derived and devided by the duration of said pump cycle.

[0061] The temperature sensor system 18 comprises at least one temperature sensor 19 provided at the container conduits 5a-b and / or the container 2.

[0062] The device 1 comprises a pressure sensor system 24 configured to in use acquire pressure condition data relating the perfusion fluid 4, which pressure sensor system 24 is operatively coupled to the control system 10 via an electrical connection. The control system 10 is configured to control the at least one valve 9a-b, 11a-b for adjusting the perfusion pressure of the perfusion fluid 4 circulated by the at least one pump 3a-b on basis of the pressure condition data as received from the pressure sensor system 24. The control system 10 determines if a present pressure value of the perfusion fluid 4 circulated by the at least one pump 3a-b equals the preferred pressure value. The pressure sensor system 24 comprises at least one pressure sensor 25a-b being in fluid communication with the container conduits 5a-b and / or the container 2.

[0063] The control system 10 is configured to increase the perfusion pressure of the perfusion fluid 4 circulated by the at least one pump 3a-b when the temperature condition data indicate that a temperature of the perfusion fluid 4 and / or of the organ or tissue increases. The control system 10 may increase the perfusion pressure of the perfusion fluid 4 linearly or non-linearly with respect to the increase of the temperature of the perfusion fluid 4 and / or of the organ or tissue indicated by the temperature condition data.

[0064] The control system 10 is also configured to decrease the perfusion pressure of the perfusion fluid 4 circulated by the at least one pump 3a-b when the temperature condition data indicate that a temperature of the perfusion fluid 4 and / or of the organ or tissue decreases. The control system 10 may decrease the perfusion pressure of the perfusion fluid 4 linearly or non-linearly with respect to the decrease of the temperature of the perfusion fluid 4 and / or of the organ or tissue indicated by the temperature condition data.

[0065] The control system 10 is configured to operate the at least one pump 3a-b in a first operation mode, in a second operation mode, and in a third operation mode.

[0066] In the first operation mode, the perfusion pressure of the circulated perfusion fluid 4 is a low perfusion pressure. The first operation mode is applied when the temperature of the perfusion fluid 4 and / or of the organ or tissue indicated by the temperature condition data is a low temperature.

[0067] In the second operation mode, the perfusion pressure of the circulated perfusion fluid 4 is an intermediate perfusion pressure. The second operation mode is applied when the temperature of the perfusion fluid 4 and / or of the organ or tissue indicated by the temperature condition data is an intermediate temperature. The intermediate perfusion pressure is higher than the low perfusion pressure. The intermediate temperature is higher than the low temperature.

[0068] In the third operation mode, the perfusion pressure of the circulated perfusion fluid 4 is a high perfusion pressure. The third operation mode is applied when the temperature of the perfusion fluid 4 and / or of the organ or tissue indicated by the temperature condition data is a high temperature. The high perfusion pressure is higher than the intermediate perfusion pressure. The high temperature is higher than the intermediate temperature.

[0069] The low temperature is between, and including, 0 - 12 degrees Celsius, or between, and including, 8 - 10 degrees Celsius. The intermediate temperature is between, and including, 12 - 25 degrees Celsius, or between, and including, 20 - 23 degrees Celsius. The high temperature is between, and including, 25 - 39 degrees Celsius, or between, and including, 35 - 37 degrees Celsius. The low perfusion pressure is between, and including, 15 - 35 mmHg, or between, and including, 23 - 30 mmHg. The intermediate perfusion pressure is between, and including, 35 - 65 mmHg, or between, and including, 45 - 60 mmHg. The high perfusion pressure is between, and including, 65 - 100 mmHg, or between, and including, 70 - 80 mmHg.

[0070] At least one flow rate meter 16a-b is provided in the container conduits 5a-b to measure a perfusion flow rate of the perfusion fluid 4 through said container conduits 5a-b. The flow rate meter 16a-b is electrically connected to the control system 10.

[0071] At least one gas pressure sensor 26a-b is connected to the vessel conduits 8a-b to measure a gas pressure of the pressurised gas in said vessel conduits 8a-b. The gas pressure sensor 26a-b is electrically connected to the control system 10.

[0072] The at least valve comprises at least one primary valve 9a-b, and the control system 10 is configured to control via the at least one primary valve 9a-b a gas frequence of the pulsating gas flow provided to the at least one pump 3a-b.

[0073] The at least valve comprises at least one secondary valve 11a-b, and the control system 10 is configured to control via the at least one secondary valve 11a-b a gas pressure of the pulsating gas flow provided to the at least one pump 3a-b.

[0074] The pressurised gas from the at least one gas vessel 7 preferably comprises oxygen. The pressurised gas may be an oxygen / carbon dioxide gas mixture or any other gas or gas mixture.

[0075] The figure 2 and 3 show a view in perspective of the pump 3a-b of the device 1 of figure 1. The pump 3 is a membrane pump and comprises a membrane 28. The primary valve 9 is fixed to the pump housing 29 of the pump 3. The primary valve 9 has three connectors, namely a first connector 31 , a second connector 32, and a third connector 33. The primary valve 9 can switch between two positions in which two of the three connector 31, 32, 33 are in open connection with one another. The first connector 31 is connected via a vessel conduit section 36 to the combined inlet and outlet 30 of the gas part 34 of the pump 3. The second connector 32 is used to discharge the pressurised gas from the pump 3. The third connector 33 is used to supply the pressurised gas to the pump 3. The first connector 31 is always in open connection with one of the second connector 32 and the third connector 33.

[0076] The pump 3 comprises a perfusion outlet 14 and a perfusion inlet 15. The perfusion fluid 4 is supplied to the fluid part 35 of the pump 3 via the perfusion inlet 15 and leaves the fluid part 35 via the perfusion outlet 14. The pump 3 comprises a fluid reservoir 38 to hold perfusion fluid 4.

[0077] The gas part 34 of the pump 3 is separated from the fluid part 35 by the membrane 28. In the rest position, the primary valve 9 is switched into a first position in which the first connector 31 is in open connection with the second connector 32 for the discharge of the pressurised gas. For driving the pump 3, the primary valve 9 is switched into the second position in which the first connector 31 is in open connection with the third connector 33 to supply the pressurised gas. The pressurised gas flows into the gas part 34 and creates an overpressure in the gas part 34. As a result, the membrane 28 will move upwards. This results in an overpressure in the fluid part 35. Due to a first fluid one-way valve 37, the perfusion fluid 4 located from the fluid reservoir 38 can only flow into (and therefore not out of) the fluid part 34. A second fluid one-way valve 39 ensures that the perfusion fluid 4 can only flow from the fluid part 35 out of the perfusion outlet 14.

[0078] The primary valve 9 is subsequently switched again back into the first position and the pressurised gas will flow out of the gas part 34 via the combined inlet and outlet 30 into the vessel conduit section 36. Said pressurised gas will leave the primary valve 9 via the second connector 32. The membrane 28 will move downwards in the direction of the rest position. This will create an underpressure in the fluid part 35 with respect to the fluid reservoir 38. The first one-way valve 37 will open and the perfusion fluid 4 will flow from the fluid reservoir 38 into the fluid part 35. By repeating the cycle described above, the pump 3 can be used for pumping the perfusion fluid 4.

[0079] The figures 4a and 4b show views in perspective of a further embodiment of the device 1 according to the invention. The device 1 has a housing 40 comprises a base surface 20, side walls 21 and a cover 22. The device 1 is in use preferably positioned with the base surface 20 on a horizontal support surface. The housing 40 may be made from expanded polystyrene or biofoam.

[0080] A closable opening 41 is provided at the side wall 21 of the housing 40. Items, such as the gas vessel 7 and the battery 17 shown in figure 1 and cooling members, can be positioned in the housing 40 through this opening 41.

[0081] The cover 22 of the housing 40 has been removed in figure 4b. The container cover 42 of the container 2 has been removed to show the inside of the container 2.

[0082] A user interface unit 43 has been provided to interact with the control system 10. Said user interface 43 is electrically connected to the control system 10.

[0083] As required, detailed embodiments of the present invention are disclosed herein; however, it is to be understood that the disclosed embodiments are merely exemplary of the invention, which can be embodied in various forms. Therefore, specific structural and functional details disclosed herein are not to be interpreted as limiting, but merely as a basis for the claims and as a representative basis for teaching one skilled in the art to variously employ the present invention in virtually any appropriately detailed structure. Further, the terms and phrases used herein are not intended to be limiting, but rather, to provide an understandable description of the invention. The terms "a" or "an", as used herein, are defined as one or more than one. The term plurality, as used herein, is defined as two or more than two. The term another, as used herein, is defined as at least a second or more. The terms including and / or having, as used herein, are defined as comprising (i.e. , open language, not excluding other elements or steps). Any reference signs in the claims should not be construed as limiting the scope of the claims or the invention.

[0084] It will be apparent to those skilled in the art that various modifications can be made to the device and method shown in the drawings without departing from the scope as defined in the claims.

[0085] The following items correspond to the reference numbers used in the figures 1, 2, 3, 4a, and 4b.

[0086] 1. device

[0087] 2. container

[0088] 3. pneumatic pumps

[0089] 4. perfusion fluid

[0090] 5. container conduits

[0091] 6. holder

[0092] 7. gas vessel

[0093] 8. vessel conduits

[0094] 9. primary valve

[0095] 10. control system

[0096] 11. secondary valve

[0097] 12. oxygenator

[0098] 13. expansion tank

[0099] 14. perfusion outlet

[0100] 15. perfusion inlet

[0101] 16. flow rate meter

[0102] 17. battery

[0103] 18. temperature sensor system

[0104] 19. temperature sensor

[0105] 20. base surface

[0106] 21. side wall

[0107] 22. cover

[0108] 23. database

[0109] 24. pressure sensor system

[0110] 25. pressure sensor 26. gas pressure sensor

[0111] 27. dedicated container conduit

[0112] 28. membrane

[0113] 29. pump housing

[0114] 30. combined inlet and outlet

[0115] 31. first connector

[0116] 32. second connector

[0117] 33. third connector

[0118] 34. gas part

[0119] 35. fluid part

[0120] 36. vessel conduit section

[0121] 37. first fluid one-way valve

[0122] 38. fluid reservoir

[0123] 39. second fluid one-way valve

[0124] 40. housing

[0125] 41. closable opening

[0126] 42. container cover

[0127] 43. user interface unit

Claims

CLAIMS1. Device for transporting an organ or tissue, comprising:- a container for containing the organ or tissue,- at least one pneumatic pump configured to pump a perfusion fluid,- container conduits connected to the at least one pump for circulating the perfusion fluid through the container,- a holder for holding at least one gas vessel comprising pressurised gas, and- at least one vessel conduit for in use connecting the at least one gas vessel to the at least one pump,- at least one valve provided at the at least one vessel conduit,- a control system configured to control the at least one valve for providing a pulsating gas flow to the at least one pump for pumping the perfusion fluid, which control system is operatively coupled to the at least one valve,- a temperature sensor system configured to in use acquire temperature condition data relating the perfusion fluid and / or relating the organ or tissue, which temperature sensor system is operatively coupled to the control system, and wherein- the control system is configured to control the at least one valve in order to adjust a perfusion pressure of the perfusion fluid circulated by the at least one pump on basis of the temperature condition data as received from the temperature sensor system.

2. Device according to claim 1, wherein the control system is configured to determine a preferred pressure value for the perfusion fluid circulated by the at least one pump.

3. Device according to claim 2, wherein the control system is configured to generate at least one control command based on said preferred pressure value and the at least one valve is configured to actuate according to the at least one control command to circulate the perfusion fluid via the at least one pump at the preferred pressure value.

4. Device according to claim 2 or 3, wherein the control system is configured to perform at least one calculation on the temperature condition data and / or at least one comparison of the temperature condition data with a database comprising predetermined pressure values for predetermined temperature condition data in order to determine the preferred pressure value.

5. Device according to claim 4, wherein the control system is configured to generate the at least one control command on basis of said at least one calculation and / or said at leastone comparison.

6. Device according to any one of the preceding claims, wherein the temperature sensor system comprises at least one temperature sensor provided at the container conduits and / or the container.

7. Device according to any one of the preceding claims, wherein:- the device comprises a pressure sensor system configured to in use acquire pressure condition data relating the perfusion fluid, which pressure sensor system is operatively coupled to the control system, and- the control system is configured to control the at least one valve for adjusting the perfusion pressure of the perfusion fluid circulated by the at least one pump on basis of the pressure condition data as received from the pressure sensor system.

8. Device according to claim 7, wherein the control system is configured to determine if a present pressure value of the perfusion fluid circulated by the at least one pump equals the preferred pressure value.

9. Device according to claim 7 or 8, wherein the pressure sensor system comprises at least one pressure sensor being in fluid communication with the container conduits and / or the container.

10. Device according to any one of the preceding claims, wherein the control system is configured to increase or decrease the perfusion pressure of the perfusion fluid circulated by the at least one pump when the temperature condition data indicate that a temperature of the perfusion fluid and / or of the organ or tissue increases or decreases.

11. Device according to claim 10, wherein the control system is configured to increase or decrease the perfusion pressure of the perfusion fluid linearly or non-linearly with respect to the increase or decrease of the temperature of the perfusion fluid and / or of the organ or tissue indicated by the temperature condition data.

12. Device according to any one of the preceding claims, wherein the control system is configured to operate the at least one pump:- in a first operation mode, wherein the perfusion pressure of the circulated perfusion fluid is a low perfusion pressure, when the temperature of the perfusion fluid and / or of the organ or tissue indicated by the temperature condition data is a low temperature,- 15 -- in a second operation mode, wherein the perfusion pressure of the circulated perfusion fluid is an intermediate perfusion pressure, when the temperature of the perfusion fluid and / or of the organ or tissue indicated by the temperature condition data is an intermediate temperature, which intermediate perfusion pressure is higher than the low perfusion pressure, and which intermediate temperature is higher than the low temperature, and- in a third operation mode, wherein the perfusion pressure of the circulated perfusion fluid is a high perfusion pressure, when the temperature of the perfusion fluid and / or of the organ or tissue indicated by the temperature condition data is a high temperature, which high perfusion pressure is higher than the intermediate perfusion pressure, and the high temperature is higher than the intermediate temperature.

13. Device according to claim 12, wherein- the low temperature is between, and including, 0 - 12 degrees Celsius, or between, and including, 8 - 10 degrees Celsius,- the intermediate temperature is between, and including, 12 - 25 degrees Celsius, or between, and including, 20 - 23 degrees Celsius, and- the high temperature is between, and including, 25 - 39 degrees Celsius, or between, and including, 35 - 37 degrees Celsius.

14. Device according to claim 12 or 13, wherein- the low perfusion pressure is between, and including, 15 - 35 mmHg, or between, and including, 23 - 30 mmHg,- the intermediate perfusion pressure is between, and including, 35 - 65 mmHg, or between, and including, 45 - 60 mmHg, and- the high perfusion pressure is between, and including, 65 - 100 mmHg, or between, and including, 70 - 80 mmHg.

15. Device according to any one of the preceding claims, wherein the at least one valve comprises at least one primary valve, and the control system is configured to control via the at least one primary valve a gas frequence of the pulsating gas flow provided to the at least one pump.

16. Device according to any one of the preceding claims, wherein the at least one valve comprises at least one secondary valve, and the control system is configured to control via the at least one secondary valve a gas pressure of the pulsating gas flow provided to- 16 - the at least one pump.

17. Method for transporting an organ or tissue, comprising placing an organ or tissue in a container, closing said container and pumping a perfusion fluid as well as a gas, preferably an oxygen containing gas, into said container, said pumping of the perfusion fluid being caused by a pulsating gas flow of said gas, wherein the pulsating gas flow is provided to at least one pneumatic pumps, and a perfusion pressure of the perfusion fluid circulated by the at least one pump through the container is controlled on basis of on temperature condition data relating the perfusion fluid and / or relating the organ or tissue.

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