Cosmetic cream-gel with three exosomes for the treatment of cellulite, body firming, silhouette sculpting, and activation of the cellular lipolysis mechanism

Abstract

The present invention relates to a cosmetic body cream-gel based on a combination of three exosomes — CITRUS RETICULATA FRUIT EXTRACT, CITRUS PARADISI FRUIT EXTRACT, and CITRULLUS LAVATUS FRUIT EXTRACT — in combination with a mixture of active ingredients including CAFFEINE, COFFEA ARABICA SEED EXTRACT, LECITHIN, NEPHELIUM LONGANA SEED EXTRACT, MACADAMIA TERNIFOLIA SEED OIL, ETHYL XIMENYNATE, and ESCIN. The defined ratio of these components gradually improves the appearance of the skin in the areas of application and reverses the manifestations of cellulite through skin smoothing, enhancement of skin firmness, and body contouring, achieved by activation of the cellular lipolysis mechanism.

Description

Cosmetic cream-gel with three exosomes for the treatment of cellulite, body firming, silhouette sculpting, and activation of the cellular lipolysis mechanism

[0001] The present invention relates to the field of cosmetic compositions. More specifically, it concerns a cream-gel formulation comprising exosomes of plant origin combined with a mixture of active ingredients for reducing cellulite, enhancing skin firmness, promoting body contouring, and stimulating the cellular lipolysis mechanism.

[0002] Various cosmetic products aiming to address cellulite and local fat accumulation are available on the market. However, these products often fail to ensure sufficient delivery of active ingredients into the target cells, limiting their effectiveness. The absence of efficient cellular uptake mechanisms reduces their ability to stimulate lipolysis and restore skin firmness.

[0003] The invention provides a cosmetic cream-gel comprising a combination of three exosomes — Citrus reticulata fruit extract, Citrus paradisi fruit extract, and Citrullus lanatus fruit extract — together with an active complex including caffeine, Coffea arabica seed extract, lecithin, Nephelium longana seed extract, Macadamia ternifolia seed oil, ethyl ximenynate, and escin. This synergistic composition effectively reduces cellulite, promotes silhouette sculpting, enhances skin elasticity, and activates cellular lipolysis.

[0004] Conventional cosmetic anti-cellulite formulations do not achieve optimal transdermal delivery of bioactive compounds to dermal fibroblasts. This results in limited stimulation of collagen synthesis, poor lipolytic activity, and insufficient improvement in skin elasticity and firmness.

[0005] The present invention introduces, for the first time, the combined application of exosomes derived from Citrus reticulata, Citrus paradisi, and Citrullus lanatus with selected active ingredients.

[0006] Exosomes, as natural nanovesicles (50–200 nm), act as carriers, ensuring targeted delivery of the active compounds into dermal fibroblasts.

[0007] Citrus exosomes inhibit collagenase and elastase activity, increase elastin and collagen levels, and stimulate hyaluronic acid production, improving hydration and firmness.

[0008] Grapefruit and watermelon exosomes, rich in essential amino acids, enhance cellular glycolysis and oxidative phosphorylation, increasing ATP production and fibroblast activity.

[0009] The additional complex (caffeine, lecithin, Nephelium longana seed extract, macadamia oil, ethyl ximenynate, and escin) provides complementary lipolytic, firming, microcirculatory, and moisturizing effects.

[0010] -Enhanced delivery of active molecules to dermal cells through exosomal transport.

[0011] -Synergistic action of exosomes with plant-derived actives ensures stronger cellulite reduction and silhouette sculpting.

[0012] -Increased collagen and elastin synthesis leads to improved skin firmness and elasticity.

[0013] -Stimulation of lipolysis reduces fat accumulation and prevents new adipocyte storage.

[0014] - Improvement in skin microcirculation contributes to faster visible results against cellulite.

[0015] The invention can be industrially applied in the cosmetics sector for the development and large-scale production of cream-gel formulations with proven efficacy against cellulite. The standardized preparation process ensures reproducibility, safety, and compliance with cosmetic regulatory frameworks.Preparation ProcessIngredients:

[0016] A / AINCI NAMES% w / w1AQUA (WATER)62,3902DISODIUM EDTA0,1003CAFFEINE(65-70%), COFFEA ARABICA (COFFEE) SEED EXTRACT(25-30%), LECITHIN(5-10%)2,0004ESCIN0,2005XANTHAN GUM0,2006SUCROSE POLYSTEARATE(>50%), CETEARYL ALCOHOL(25-50%), OLEA EUROPAEA (OLIVE) OIL UNSAPONIFIABLES(1-4.99%)2,0007BUTYLENE GLYCOL DICAPRYLATE / DICAPRATE2,0008CETEARYL ALCOHOL1,0009ETHYLHEXYL PALMITATE3,00010CAPRYLIC / CAPRIC TRIGLYCERIDE(80-90%), HYDROGENATED RAPESEED OIL(10-20%)0,50011MACADAMIA TERNIFOLIA SEED OIL1,00012TOCOPHEROL(70%), HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL(30%)0,05013ETHYL XIMENYNATE(>50%), BHT(<0,1%)1,00014CYCLOPENTASILOXANE(>60%), DIMETHICONOL(<40%)1,00015DIMETHICONE2,00016SODIUM ACRYLATES COPOLYMER(35-45%), HYDROGENATED POLYDECENE(25-35%), PHOSPHOLIPIDS(5-15%), POLYGLYCERYL-10 STEARATE(5-15%), HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL(5-15%), TOCOPHEROL(0,1%)1,50017PHENOXYETHANOL0,80018CHLORPHENESIN0,25019BUTYLENE GLYCOL2,000201,2-HEXANEDIOL0,30021PARFUM (FRAGRANCE), ALPHA-ISOMETHYL IONONE(0,69%), AMYL CINNAMAL(0,003%), ANISE ALCOHOL(0.004%), BENZALDEHYDE(0,72%), BENZYL ALCOHOL(0.009%), BENZYL BENZOATE(0,007%), CITRONELLOL(3.395%), EUGENOL(0.36%), GERANIOL(0.008%), HEXAMETHYLINDANOPYRAN(5,76%), HEXYL CINNAMAL(7.04%), LIMONENE(4.499%), LINALOOL(0.014%), PINENE(0,037%)0,70022MENTHOL0,50023AQUA (WATER)6,00024BENTONITE(>50%), BUTYROSPERMUM PARKII (SHEA) BUTTER EXTRACT, PERSEA GRATISSIMA (AVOCADO) FRUIT EXTRACT1,00025GLYCERIN(60-70%), AQUA(20-30%), NEPHELIUM LONGANA SEED EXTRACT(5-10%)2,00026GLYCERIN(30%), CITRUS RETICULATA (TANGERINE) FRUIT EXTRACT(67%), 1,2-HEXANEDIOL(3%)1,00027AQUA(71%), CITRUS PARADISI (GRAPEFRUIT) FRUIT EXTRACT(20%), CITRULLUS LANATUS (WATERMELON) FRUIT EXTRACT(10%), PHOSPHOLIPIDS(5%), LACTOBACILLUS FERMENT(4%)3,00028POLYMETHYLSILSESQUIOXANE(55-65%), HDI / TRIMETHYLOL HEXYLLACTONE CROSSPOLYMER(35-45%)0,50029DIMETHICONE(70-74%), POLYSILICONE-11(8-10%), BUTYROSPERMUM PARKII (SHEA) BUTTER(6-8%), AQUA(5-7%), GLYCERIN(3-6%), DECYL GLUCOSIDE(0.1-0.3%), PHENOXYETHANOL(<0.1%), CAPRYLYL GLYCOL(<0.1%), HEXYLENE GLYCOL(<0.1%)1,00030AQUA (WATER)1,00031SODIUM HYDROXIDE0,010

[0017] Preparation ProcessThe order in which the individual ingredients are added, the stirring times, and the general production conditions are precisely defined to ensure consistent results and the same physicochemical specifications. The cosmetic form of the product is a cream-gel obtained by mixing and emulsifying the aqueous and oily phases after heating them to 70–75 °C to create the product base.AQUEOUS PHASE:- AQUA (WATER) deionized water- DISODIUM EDTA (disodium salt of ethylenediaminetetraacetic acid)- XANTHAN GUMOILY PHASE:- Mixture of SUCROSE POLYSTEARATE (>50%), CETEARYL ALCOHOL (25-50%), OLEA EUROPAEA (OLIVE) OIL UNSAPONIFIABLES (1-4.99%)- BUTYLENE GLYCOL DICAPRYLATE / DICAPRATE- CETEARYL ALCOHOL- ETHYLHEXYL PALMITATE- Mixture of CAPRYLIC / CAPRIC TRIGLYCERIDE (80-90%), HYDROGENATED RAPESEED OIL (10-20%)- Mixture of TOCOPHEROL (70%), HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL (30%)- Mixture of ETHYL XIMENYNATE (>50%), BHT (<0.1%)Into the base cream-gel we then add with vigorous stirring and in order:- MACADAMIA TERNIFOLIA SEED OIL- Mixture (CAFFEINE (65-70%), COFFEA ARABICA (COFFEE) SEED EXTRACT (25-30%), LECITHIN (5-10%))- Mixture GLYCERIN (30%), CITRUS RETICULATA (TANGERINE) FRUIT EXTRACT (67%), 1,2-HEXANEDIOL (3%)

[0018] Finally, we add fragrance (PARFUM (FRAGRANCE), ALPHA-ISOMETHYL IONONE(0,69%), AMYL CINNAMAL (0,003%), ANISE ALCOHOL (0.004%), BENZALDEHYDE(0,72%),BENZYL ALCOHOL (0.009%), BENZYL BENZOATE (0,007%), CITRONELLOL (3.395%), EUGENOL(0.36%), GERANIOL (0.008%), HEXAMETHYLINDANOPYRAN (5,76%), HEXYL CINNAMAL (7.04%), LIMONENE(4.499%), LINALOOL (0.014%), PINENE (0,037%)) and the pH is adjusted within specification limits (5.7–6.3). The total microbial count (TMC) is up to 100 col / gr, and the product is free of Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans.

[0019] The product is applied to affected body areas through intensive massage twice daily. The result is the gradual improvement of skin appearance in the treated areas and the reversal of cellulite signs by smoothing the skin while promoting its firmness within a few weeks.

Claims

A cosmetic body cream-gel based on a mixture of the three exosomes CITRUS RETICULATA FRUIT EXTRACT, CITRUS PARADISI FRUIT EXTRACT, and CITRULLUS LANATUS FRUIT EXTRACT, in combination with the mixture of active ingredients CAFFEINE, COFFEA ARABICA SEED EXTRACT, LECITHIN, NEPHELIUM LONGANA SEED EXTRACT, MACADAMIA TERNIFOLIA SEED OIL, ETHYL XIMENYNATE, and ESCIN, for the treatment of cellulite, the firming of body skin, as well as the sculpting of the silhouette through activation of the cellular lipolysis.Cosmetic use of a mixture of the three exosomes CITRUS RETICULATA FRUIT EXTRACT, CITRUS PARADISI FRUIT EXTRACT, and CITRULLUS LANATUS FRUIT EXTRACT as an agent for the treatment of cellulite, the firming of body skin, the sculpting of the silhouette and the activation of the cellular lipolysis mechanism.