Skin care compositions

Abstract

Skin care compositions and, e.g., skin care compositions containing retinol and salicylic acid are disclosed herein. In accordance with one aspect, provided is a skin care composition comprising: a retinoid; salicylic acid, and / or a salt thereof; from about 1.5 to about 17 wt.% of a silicone; from about 1 to about 8 wt.% of a vitamin B; from about 5 to about 40 wt.% of a fatty component; and water, wherein the skin care composition has a pH of about 4.75 to about 6.7 and all weight percentages are based on the total weight of the skin care composition.

Description

Docket No. 863910-00-WO-01-SHSKIN CARE COMPOSITIONSCROSS-REFERENCE TO RELATED APPLICATION

[0001] This application claims the benefit of priority from U.S. Patent Application No. 63 / 702,233, filed October 2, 2024, and from U.S. Patent Application No. 63 / 702,228, filed October 2, 2024, the contents of both are hereby incorporated herein by reference in their entirety.BACKGROUND

[0002] Skin produces less collagen and elastin as it ages. For example, after the age of twenty, a person (human) produces about 1 percent less collagen in the skin each year. As a result, the skin becomes thinner and more fragile. Inevitably, wrinkles, crow’s feet, age-spots, eye bags, and the like, begin to form.

[0003] Consumers often wish to improve the appearance of such age-related skin imperfections, preferably with instantaneous results. Many consumer products and procedures devoted to hiding and reducing wrinkles are available. Some products and procedures are simple and inexpensive, for example, applying make-up, particularly a primer or colored foundation, to cover the skin (and thereby cover and / or fill the wrinkles and provide a smoother look). Far more expensive and drastic procedures, such as surgical face lifts and Botox® injections, are also used to reduce the appearance of wrinkles. However, many consumers either cannot afford, or do not wish, to undergo such drastic cosmetic procedures.

[0004] There are a number of lotions and creams which are formulated to hydrate the skin and make it more supple, thereby reducing the appearance of wrinkles. Some of these products contain active ingredients that help repair and rejuvenate skin over time. Oftentimes, as the potency of a skin active increases, its level of instability in formula will also increase. Therefore, skincare products featuring highly potent actives also run the risk of featuring unacceptable levels of degradation. One such active that features this unfortunate condition is retinol, a form of vitamin A with proven anti-aging and anti-acne benefits. Retinol is sensitive to a variety of stimuli such as light, temperature, water and particularly oxygen. Thus, it can be difficult to stabilize retinol in skin care compositions. This is further complicated if the skincare product contains any further active(s). The additional actives may interact with retinol in a deleterious way and / or impose new formulation conditions that adversely impact the stability of retinol.Docket No. 863910-00-WO-01-SH

[0005] There is a growing need for skin care formulations with anti-ageing effects, which can improve the health and / or appearance of skin.BRIEF SUMMARY

[0006] This summary is intended merely to introduce a simplified summary of some aspects of one or more implementations of the present disclosure. Further areas of applicability of the present disclosure will become apparent from the detailed description provided hereinafter. This summary is not an extensive overview, nor is it intended to identify key or critical elements of the present teachings, nor to delineate the scope of the disclosure. Rather, its purpose is merely to present one or more concepts in simplified form as a prelude to the detailed description below.

[0007] Aspects of the invention are directed to skin care compositions and, e.g., skin care compositions containing retinol and salicylic acid. It was reasonably expected that the retinol would readily degrade in the presence of salicylic acid. However, the skin care compositions disclosed herein advantageously achieve a desirable level of retinol stability while containing salicylic acid and / or a salt thereof. Further, the inventors discovered that skin care compositions having certain combinations of ingredients can contain both retinol and salicylic acid without unduly causing skin irritation.

[0008] In accordance with one aspect, provided is a skin care composition comprising: a retinoid; salicylic acid, and / or a salt thereof; from about 1.5 to about 17 wt.% of a silicone; from about 1 to about 8 wt.% of a vitamin B; from about 5 to about 40 wt.% of a fatty component; and water, wherein the skin care composition has a pH of about 5.5 to about 6.7 and all weight percentages are based on the total weight of the skin care composition

[0009] A list of non-limiting embodiments in accordance with aspects of the invention is provided below:

[0010] In an embodiment 1, provided is a skin care composition comprising: a retinoid; salicylic acid, and / or a salt thereof; from about 1.5 to about 17 wt.% of a silicone; from about 1 to about 8 wt.% of a vitamin B; from about 5 to about 40 wt.% of a fatty component; and water, wherein the skin care composition has a pH of about 5.5 to about 6.7 and all weight percentages are based on the total weight of the skin care composition.

[0011] In accordance with an embodiment 2, provided is the skin care composition according to embodiment 1, wherein the pH is about 6.1 to about 6.7.Docket No. 863910-00-WO-01-SH

[0012] In accordance with an embodiment 3, provided is the skin care composition according to embodiment 1 or embodiment 2, wherein the retinoid is selected from the group consisting of retinol, retinal, tretinoin, acitretin, etretinate, adapalene, arotinoid, tazarotene, retinoic acid, hydroxypinacolone retinoate, and a combination of two or more thereof.

[0013] In accordance with an embodiment 4, provided is the skin care composition according to any foregoing embodiment, wherein the retinoid is selected from retinyl esters, retinaldehyde, and a combination thereof.

[0014] In accordance with an embodiment 5, provided is the skin care composition according to embodiment 4, wherein the retinoid comprises a retinyl ester selected from retinyl palmitate, retinyl acetate retinyl propionate, and a combination thereof.

[0015] In accordance with an embodiment 6, provided is the skin care composition according to any foregoing embodiment, wherein the retinoid comprises retinol.

[0016] In accordance with an embodiment 7, provided is the skin care composition according to any foregoing embodiment, wherein the retinoid is present in an amount from about 0.1 to about 3 wt.%, based on the total weight of the skin care composition.

[0017] In accordance with an embodiment 8, provided is the skin care composition according to any foregoing embodiment, wherein the salicylic acid and / or a salt thereof is present in an amount from about 1 to about 5 wt.%, based on the total weight of the skin care composition.

[0018] In accordance with an embodiment 9, provided is the skin care composition according to any foregoing embodiment, wherein the silicone comprises dimethicone, polysilicone-11, or a combination thereof.

[0019] In accordance with an embodiment 10, provided is the skin care composition according to any foregoing embodiment, wherein the vitamin B is selected from the group consisting of vitamin B3 or derivatives thereof.

[0020] In accordance with an embodiment 11, provided is the skin care composition according to any foregoing embodiment, wherein the vitamin B comprises niacinamide, nicotinic acid, nicotinyl alcohol, a salt thereof, or a combination thereof.

[0021] In accordance with an embodiment 12, provided is the skin care composition according to any foregoing embodiment, wherein the vitamin B comprises from about 3 to about 7 wt.% of niacinamide.Docket No. 863910-00-WO-01-SH

[0022] In accordance with an embodiment 13, provided is the skin care composition according to any foregoing embodiment, wherein the fatty component comprises a fatty ester, fatty alcohol, a fatty ether, a non- silicone oil, or a combination of two or more thereof.

[0023] In accordance with an embodiment 14, provided is the skin care composition according to embodiment 13, wherein the fatty component comprises a non-silicone oil selected from isododecane, isodecane, decane, dodecane, Cn-13 isoalkane, and a combination of two or more thereof.

[0024] In accordance with an embodiment 15, provided is the skin care composition according to embodiment 13 or embodiment 14, wherein the fatty component comprises a fatty ester selected from isoamyl laurate, ethyl linoleate, ethylhexyl stearate, coco-caprylate / caprate, isoamyl cocoate, glyceryl stearate, PEG- 100 stearate, polyglyceryl-10 dipalmitate, poly glyceryl- 10 dioleate, and a combination of two or more thereof.

[0025] In accordance with an embodiment 16, provided is the skin care composition according to any one of embodiment 13 to embodiment 15, wherein the fatty component comprises a fatty alcohol, the fatty alcohol comprising cetyl alcohol, stearyl alcohol, cetearyl alcohol, lauric alcohol, or a mixture of two or more thereof.

[0026] In accordance with an embodiment 17, provided is the skin care composition according to any foregoing embodiment, wherein the water is present in an amount from about 20 to about 60 wt.%.

[0027] In accordance with an embodiment 18, provided is the skin care composition according to any foregoing embodiment further comprising: a polyol, optionally, in an amount from about 0.5 to about 20 wt.%.

[0028] In accordance with an embodiment 19, provided is the skin care composition according to embodiment 18, wherein the polyol comprises glycerin, propylene glycol, capryl glycol, ethylene glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, diglycerin, diethylene glycol, dipropylene glycol, or a combination thereof.

[0029] In accordance with an embodiment 20, provided is the skin care composition according to any foregoing embodiment further comprising: a skin conditioning agent comprising syringa vulgaris leaf cell culture extract, dipotassium glycyrrhizinate, bakuchiol, hydrogenated olive oil unsaponifiables, hydrogenated ethylhexyl olivate, or a combination of two or more thereof.Docket No. 863910-00-WO-01-SH

[0030] In accordance with an embodiment 21 , provided is the skin care composition according to any foregoing embodiment further comprising: one or more peptide comprising tripcptidc-29, acetyl tetrapeptide-2, trifluoroacetyl tripeptide-2, myristoyl nonapeptide- 3, or a combination thereof.

[0031] In accordance with an embodiment 22, provided is the skin care composition according to embodiment 21, wherein the one or more peptide comprises myristoyl nonapeptide-3.

[0032] In accordance with an embodiment 23, provided is the skin care composition according to embodiment 21 or embodiment 22, wherein the one or more peptide consists of myristoyl nonapeptide-3 and at least one of tripep tide-29, acetyl tetrapeptide-2, or trifluoroacetyl tripeptide - 2.

[0033] In accordance with an embodiment 24, provided is the skin care composition according to any foregoing embodiment, wherein the skin care composition is substantially free of or free of anionic surfactants and cationic surfactants.

[0034] In accordance with an embodiment 25, provided is the skin care composition according to any foregoing embodiment, wherein the skin care composition is substantially free of or free of amphoteric surfactants.BRIEF DESCRIPTION OF THE DRAWINGS

[0035] The present invention may become more fully understood from the detailed description and the accompanying drawings, wherein like elements are labeled similarly and in which:

[0036] FIG. 1 is a bar graph of the stability of retinol in a comparative composition and nonlimiting example compositions according to aspects of the invention;

[0037] FIG. 2 is a bar graph of the KRT15 expression in NHEK cells after incubation with a comparative composition or non-limiting example compositions according to aspects of the invention;

[0038] FIG. 3 is a bar graph of the HBEGF expression in NHEK cells after incubation with a comparative composition or non-limiting example compositions according to aspects of the invention; and

[0039] FIG. 4 is a bar graph of the MMP1 expression in NHEK cells after incubation with a comparative composition or non-limiting example compositions according to aspects of the invention.

[0040] It should be understood that the various aspects are not limited to the arrangements andDocket No. 863910-00-WO-01-SH instrumentality shown in the drawings.DETAILED DESCRIPTION

[0041] For illustrative purposes, the principles of the present invention are described by referencing various exemplary embodiments thereof. Although certain embodiments of the invention are specifically described herein, one of ordinary skill in the art will readily recognize that the same principles are equally applicable to, and can be employed in other apparatuses and methods. Before explaining the disclosed embodiments of the present invention in detail, it is to be understood that the invention is not limited in its application to the details of any particular embodiment shown. The terminology used herein is for the purpose of description and not of limitation.

[0042] As used herein and in the appended claims, the singular forms “a”, “an”, and “the” include plural references unless the context dictates otherwise. The singular form of any class of the ingredients refers not only to one chemical species within that class, but also to a mixture of those chemical species. The terms “a” (or “an”), “one or more” and “at least one” may be used interchangeably herein. The terms “comprising”, “including”, and “having” may be used interchangeably. The term “include” should be interpreted as “include, but are not limited to”. The term “including” should be interpreted as “including, but are not limited to”.

[0043] As used throughout, ranges arc used as shorthand for describing each and every value that is within the range. Any value within the range can be selected as the terminus of the range. Thus, a range from 1-5, includes specifically 1, 2, 3, 4 and 5, as well as subranges such as 2-5, 3-5, 2-3, 2-4, 1-4, etc.

[0044] The term “about” when referring to a number means any number within a range of 10% of the number. For example, the phrase “about 2 wt.%” refers to a number between and including 1.8 wt.% and 2.2 wt.%.

[0045] All references cited herein are hereby incorporated by reference in their entireties. In the event of a conflict in a definition in the present disclosure and that of a cited reference, the present disclosure controls.

[0046] The abbreviations and symbols as used herein, unless indicated otherwise, take their ordinary meaning. The abbreviation “wt.%” means percent by weight with respect to the skin care composition. The symbol “°” refers to a degree, such as a temperature degree or a degree of an angle. The symbols “h”, “min”, “mL”, “nm”, and “pm” refer to hour, minute, milliliter, nanometer,Docket No. 863910-00-WO-01-SH and micrometer, respectively. The abbreviation “UV-VIS” as referring to a spectrometer or spectroscopy, means Ultraviolet- Visible. The abbreviation “rpm” means revolutions per minute.

[0047] When referring to chemical structures, and names, the symbols “C”, “H”, and “O” mean carbon, hydrogen, and oxygen, respectively. The symbols “=” and “=” mean single bond, double bond, and triple bond, respectively.

[0048] “ Volatile”, as used herein, means having a flash point of less than about 100° C. “Nonvolatile”, as used herein, means having a flash point of greater than about 100° C.

[0049] “Cosmetically acceptable” means that the item in question is compatible with a keratinous substrate, such as skin. For example, a “cosmetically acceptable carrier” means a carrier that is compatible with a keratinous substrate, such as skin.

[0050] Any member in a list of species that are used to exemplify or define a genus, may be mutually different from, or overlapping with, or a subset of, or equivalent to, or nearly the same as, or identical to, any other member of the list of species. Further, unless explicitly stated, such as when reciting a Markush group, the list of species that define or exemplify the genus is open, and it is given that other species may exist that define or exemplify the genus just as well as, or better than, any other species listed.

[0051] The phrases, “a mixture thereof,” “a combination thereof,” or a combination of two or more thereof’ do not require that the mixture include all of A, B, C, D, E, and F (although all of A, B,C, D, E, and F may be included). Rather, it indicates that a mixture of any two or more of A, B, C,D, E, and F can be included. In other words, it is equivalent to the phrase “one or more elements selected from the group consisting of A, B, C, D, E, F, and a mixture of any two or more of A, B, C, D, E, and E” Likewise, the term “a salt thereof” also relates to “salts thereof.” Thus, where the disclosure refers to “an element selected from the group consisting of A, B, C, D, E, F, a salt thereof, and a mixture thereof,” it indicates that that one or more of A, B, C, D, and F may be included, one or more of a salt of A, a salt of B, a salt of C, a salt of D, a salt of E, and a salt of F may be included, or a mixture of any two of A, B, C, D, E, F, a salt of A, a salt of B, a salt of C, a salt of D, a salt of E, and a salt of F may be included.

[0052] All components and elements positively set forth in this disclosure can be negatively excluded from the claims. In other words, the skin care compositions of the instant disclosure can be free or essentially free of all components and elements positively recited throughout the instant disclosure. In some instances, the skin care compositions of the present disclosure may beDocket No. 863910-00-WO-01-SH substantially free of non-incidental amounts of the ingredient(s) or compound(s) described herein. A non-incidcntal amount of an ingredient or compound is the amount of that ingredient or compound that is added into the skin care composition by itself. For example, a skin care composition may be substantially free of a non-incidental amount of an ingredient or compound, although such ingredient(s) or compound(s) may be present as part of a raw material that is included as a blend of two or more compounds.

[0053] Some of the various categories of components identified may overlap. In such cases where overlap may exist and the skin care composition includes both components (or the composition includes more than two components that overlap), an overlapping compound does not represent more than one component. For example, certain compounds may be characterized as both an emulsifier and a surfactant. If a particular skin care composition includes both an emulsifier and a surfactant, a compound that may be characterized as both an emulsifier and a surfactant will serve only as either an emulsifier or a surfactant — not both.

[0054] For readability purposes, the chemical functional groups are in their adjective form; for each of the adjectives, the word “group” is assumed. For example, the adjective “alkyl” without a noun thereafter, should be read as “an alkyl group”.

[0055] Aspects of the invention are directed to skin care compositions and, e.g., skin care compositions containing retinol and salicylic acid. Without being limited to any particular theory, the inventors discovered that certain skin care compositions having retinol, salicylic acid, and certain pHs (e.g., a pH of about 4.75 to about 6.7) have enhanced retinol stability while simultaneously having desirable benefits of salicylic acid. These simultaneous benefits were unexpected as salicylic acid is considerably acidic (e.g., has a low pKa) and, thus, raising the pH could have been expected to degrade the benefits of salicylic acid. In accordance with one aspect, provided is a skin care composition comprising: a retinoid; salicylic acid, and / or a salt thereof; from about 1.5 to about 17 wt.% of a silicone; from about 1 to about 8 wt.% of a vitamin B; from about 5 to about 40 wt.% of a fatty component; and water, wherein the skin care composition has a pH of about 4.75 to about 6.7 and all weight percentages are based on the total weight of the skin care composition.

[0056] The skin care compositions may preferably have a pH of about 4.75 to about 6.7, about 4.75 to about 6.5, about 4.75 to about 6.3, about 4.75 to about 6.1, about 4.75 to about 5.9; about 5 to about 6.7, about 5 to about 6.5, about 5 to about 6.3, about 5 to about 6.1, about 5 to aboutDocket No. 863910-00-WO-01-SH5.9; about 5.25 to about 6.7, about 5.25 to about 6.5, about 5.25 to about 6.3, about 5.25 to about 6.1, about 5.25 to about 5.9; about 5.5 to about 6.7, about 5.5 to about 6.5, about 5.5 to about 6.3, about 5.5 to about 6.1, about 5.5 to about 5.9; from about 5.7 to about 6.7, about 5.7 to about 6.5, about 5.7 to about 6.3, about 5.7 to about 6.1, about 5.7 to about 5.9; from about 5.9 to about 6.7, about 5.9 to about 6.5, about 5.9 to about 6.3; from about 6.1 to about 6.7, about 6.1 to about 6.5, about 6.3 to about 6.7, or any range or subrange thereof. In certain preferred embodiments, the skin care composition has a pH of about 4.75 to about 6.3, about 5 to about 6.3, or about 5 to about 6.

[0057] Suitable components, such as those listed below, may be included or excluded from the formulations for the skin care compositions depending on the specific combination of other components, the form of the skin care compositions, and / or the use of the formulation (e.g., a serum, lotion, cream, gel, etc.). The skin care composition typically comprises two phases, such as hydrophilic phase and a hydrophobic phase. The two or more phases may be in the form of an oil-in-water emulsion or a water-in-oil emulsion. In some cases, the skin care composition may have a first phase, a second, phase, and a single interphase therebetween.

[0058] The skin care compositions typically comprise one or more retinoid(s). The one or more retinoid(s) may be present in an amount from about 0.1 to about 3 wt.%, based on the total weight of the skin care composition. In some instances, the total amount of the retinoid(s) in the skin care composition is from about 0.1 to about 2 wt.%, about 0.1 to about 1 wt.%, about 0.1 to about 0.8 wt.%, about 0.1 to about 0.6 wt.%, about 0.1 to about 0.5 wt.%, about 0.1 to about 0.4 wt.% about 0.1 to about 0.3 wt.%; from about 0.1 to 0.3, about 0.2 to 0.3; from about 0.3 to about 3 wt.%, about 0.3 to about 2 wt.%, about 0.3 to about 1 wt.%, about 0.3 to about 0.8 wt.%, about 0.3 to about 0.6 wt.%; from about 0.5 to about 3 wt.%, about 0.5 to about 2 wt.%, about 0.5 to about 1 wt.%, about 0.5 to about 0.8 wt.%; from about 0.7 to about 3 wt.%, about 0.7 to about 2 wt.%, about 0.7 to about 1.2 wt.%; from about 1 to about 3 wt.%, about 1 to about 2 wt.%; from about 1.5 to about 3 wt.%, about 1.5 to about 2.5 wt.%, about 2 to about 3 wt.%, or any range or subrange thereof, based on the total weight of the skin care composition.

[0059] The retinoid(s) may be selected from retinyl esters, retinaldehyde, retinoic acid, retinol, retinal, tretinoin, acitretin, etretinate, adapalene, arotinoid, tazarotene, hydroxypinacolone retinoate, and a combination of two or more thereof. For example, the retinoids may comprise or consist of retinoic acid, retinol, tretinoin, acitretin, etretinate, adapalene, arotinoid, tazarotene,Docket No. 863910-00-WO-01-SH hydroxypinacolone retinoate, and a combination of two or more thereof. In some cases, the retinoids comprise or consist of at least one of rctinyl esters and / or rctinaldchydc. Examples of retinyl esters include retinyl palmitate, retinyl acetate retinyl propionate, and a combination thereof. The skin care composition may have retinol as the sole retinoid in some embodiments.

[0060] The skin care composition may optionally include delivery vesicle(s) (e.g., a multilamellar vesicle (“MLV”)). For instance, the skin care composition may have one or more ingredients that are encapsulated in a delivery vesicle, such as a multilamellar vesicle. The multilamellar vesicle may comprise liposome structuring agents comprising polygly ceryl- 10 dioleate and at least one of polyglyceryl-10 dilinoleate or poly lyceryl-10 dipalmitate in a weight ratio of polyglyceryl-10 dioleate to the at least one of polyglyceryl-10 dilinoleate or polyglyceryl-10 dipalmitate of from 300:1 to 5:1. In some instances, the multilamellar vesicle comprises one or more ingredients selected from: polyglyceryl-10 dilinoleate, polyglyceryl-10 dipalmitate, polyglyceryl-10 dioleate, caprylic / capric triglyceride, and combinations thereof. In some embodiments, the skin care composition comprises vesicles containing the retinoid(s).

[0061] In addition to one or more retinoids, the skin care composition typically includes salicylic acid, a derivative thereof, and / or a salt thereof. The total amount of salicylic acid, a derivative thereof, and / or a salt thereof present in the skin care composition may be about 1 to about 15 wt.%, based on the total weight of the skin care composition. For example, total amount of salicylic acid, a derivative thereof, and / or a salt thereof present in the skin care composition may be from about 1 to about 12 wt.%, about 1 to about 10 wt.%, about 1 to about 8 wt.%, about 1 to about 7.5 wt.%, about 1 to about 7 wt.%, about 1 to about 6 wt.%, about 1 to about 5 wt.%; from about 1 to about 4 wt.%, about 1 to about 3 wt.%; from about 1.5 to about 5 wt.%, about 1.5 to about 4 wt.%, about 1.5 to about 3 wt.%, about 1.5 to about 2.5 wt.%; from about 2 to about 15 wt.%, about 2 to about 12 wt.%, about 2 to about 10 wt.%, about 2 to about 8 wt.%, about 2 to about 7.5 wt.%, about 2 to about 7 wt.%, about 2 to about 6 wt.%, about 2 to about 5 wt.%; from about 3 to about 15 wt.%, about 3 to about 12 wt.%, about 3 to about 10 wt.%, about 3 to about 8 wt.%, about 3 to about 7.5 wt.%, about 3 to about 7 wt.%, about 3 to about 6 wt.%; from about 5 to about 15 wt.%, about 5 to about 12 wt.%, about 5 to about 10 wt.%, about 5 to about 8 wt.%; from about 7 to about 15 wt.%, about 7 to about 12 wt.%, about 7 to about 10 wt.%, about 7 to about 8 wt.%; from about 9 to about 15 wt.%, about 9 to about 12 wt.%, or any range or subrange thereof, based on the total weight of the skin care composition.Docket No. 863910-00-WO-01-SH

[0062] In certain embodiments, the total amount of salicylic acid, a derivative thereof, and / or a salt thereof present in the skin care composition may be about 1 to about 5 wt.%, based on the total weight of the skin care composition. For example, total amount of salicylic acid, a derivative thereof, and / or a salt thereof present in the skin care composition may be from about 1 to about 4 wt.%, about 1 to about 3 wt.%, about 1 to about 2 wt.%; from about 1.5 to about 5 wt.%, about 1.5 to about 4 wt.%, about 1.5 to about 3 wt.%, about 1.5 to about 2.5 wt.%; from about 2 to about 5 wt.%, about 2 to about 4 wt.%, about 2 to about 3 wt.%; from about 2.5 to about 5 wt.%, about 2.5 to about 4 wt.%, about 2.5 to about 3.5 wt.%; from about 3 to about 5 wt.%, about 3 to about 4 wt.%, or any range or subrange thereof, based on the total weight of the skin care composition.

[0063] The salicylic acid, a derivative thereof, and / or a salt thereof may be selected from salicylic acid and salts thereof. Examples of salts of salicylic acid include sodium salicylate, potassium salicylate, calcium salicylate, or combinations thereof. A derivative of salicylic acid, such as esters of salicylic acids and / or ethers of salicylic acids, may be present in the skin care composition.

[0064] The skin care composition may include one or more vitamin B. The amount of vitamin B present in the skin care composition may be from about 1 to about 8 wt.%, based on the total weight of the skin care composition. For instance, the skin care composition may comprise a total amount of vitamin B of from about 1 to about 8 wt.%, about 1 to about 6 wt.%, about 1 to about 5 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%; from about 2 to about 8 wt.%, about 2 to about 6 wt.%, about 2 to about 5 wt.%, about 2 to about 4 wt.%, about 2 to about 3 wt.%; from about 3 to about 8 wt.%, about 3 to about 6 wt.%, about 3 to about 5 wt.%, about 3 to about 4 wt.%; from about 4 to about 8 wt.%, about 4 to about 6 wt.%, about 4 to about 5 wt.%; from about 5 to about 8 wt.%, about 5 to about 6.5 wt.%, or any range formed therefrom, based on the total weight of the skin care composition.

[0065] The one or more vitamin B may comprise or consist of vitamin B3 and / or derivatives thereof. The formula of the vitamin B3 may comprise the following structure:wherein R is -CONH2 (i.e., niacinamide), COOH (i.e., nicotinic acid) or CH2OH (i.e., nicotinyl alcohol); a derivative thereof, and / or a salt thereof.

[0066] The vitamin B3 and / or a derivative thereof may be selected from the group consisting ofDocket No. 863910-00-WO-01-SH nicotinic acid esters, non-vasodilating esters of nicotinic acid, nicotinyl amino acids, nicotinyl alcohol esters of carboxylic acids (c.g., straight-chain or branched chain, cyclic or acyclic, saturated or unsaturated (including aromatic), substituted or unsubstituted nicotinic acid N-oxide, niacinamide N-oxide, tocopherol nicotinate, inositol hexanicotinate, and a combination of two or more thereof. Examples of derivatives of niacinamide include nicotinyl amino acids, derived, c.g., from the reaction of an activated nicotinic acid compound (e.g., nicotinic acid azide or nicotinyl chloride) with an amino acid, and nicotinyl alcohol esters of organic carboxylic acids (e.g., Ci- Cis). Examples of such derivatives include nicotinuric acid and nicotinyl hydroxamic acid.

[0067] Additional derivatives of niacinamide include nicotinyl alcohol esters, such as nicotinyl alcohol esters of the carboxylic acids, salicylic acid, acetic acid, glycolic acid, palmitic acid and the like. Further examples of derivatives of niacinamide include 2-chloronicotinamide, 6- aminonicotinamide, 6-methylnicotinamide, n-methyl-nicotinamide, n,n-diethylnicotinamide, n- (hydroxymethyl)-nicotinamide, quinolinic acid imide, nicotinanilide, n-benzylnicotinamide, n- ethylnicotinamide, nifenazone, nicotinaldehyde, isonicotinic acid, methyl isonicotinic acid, thionicotinamide, nialamide, l-(3-pyridylmethyl) urea, 2-mercaptonicotinic acid, nicomol, niaprazine, and combinations thereof.

[0068] Preferably, the one or more vitamin B comprises or consists of niacinamide. In some embodiments, the total amount of vitamin B comprises niacinamide in an amount from about 1 to about 8 wt.%, about 1 to about 6 wt.%, about 1 to about 5 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%; from about 2 to about 8 wt.%, about 2 to about 6 wt.%, about 2 to about 5 wt.%, about 2 to about 4 wt.%, about 2 to about 3 wt.%; from about 3 to about 8 wt.%, about 3 to about 6 wt.%, about 3 to about 5 wt.%, about 3 to about 4 wt.%; from about 4 to about 8 wt.%, about 4 to about 6 wt.%, about 4 to about 5 wt.%; from about 5 to about 8 wt.%, about 5 to about 6.5 wt.%, or any range formed therefrom, based on the total weight of the skin care composition.

[0069] The skin care compositions typically comprise a fatty component comprising one or more fatty compound(s). The fatty component may comprise a fatty ester, fatty alcohol, a fatty ether, an oil, a wax, or a combination of two or more thereof. The fatty component, which may comprise or consist of one or more fatty ester, one or more fatty alcohol, one or more a fatty ether, one or more oil, and / or one or more wax, may be present in an amount from about 5 to about 40 wt.%, based on the total weight of the skin care composition. In some instances, the fatty compound(s) are present in an amount of about 5 to about 36 wt.%, about 5 to about 32 wt.%, about 5 to about 29Docket No. 863910-00-WO-01-SH wt.%, about 5 to about 26 wt.%, about 5 to about 23 wt.%, about 5 to about 19 wt.%, about 5 to about 15 wt.%; about 7 to about 40 wt.%, about 7 to about 36 wt.%, about 7 to about 32 wt.%, about 7 to about 29 wt.%, about 7 to about 26 wt.%, about 7 to about 23 wt.%, about 7 to about 19 wt.%, about 7 to about 15 wt.%; from about 7 to about 40 wt.%, about 7 to about 36 wt.%, about 7 to about 32 wt.%, about 7 to about 29 wt.%, about 7 to about 26 wt.%, about 7 to about 23 wt.%, about 7 to about 19 wt.%, about 7 to about 15 wt.%; from about 12 to about 40 wt.%, about 12 to about 36 wt.%, about 12 to about 32 wt.%, about 12 to about 29 wt.%, about 12 to about 26 wt.%, about 12 to about 23 wt.%, about 12 to about 19 wt.%; from about 17 to about40 wt.%, about 17 to about 36 wt.%, about 17 to about 32 wt.%, about 17 to about 29 wt.%, about 17 to about 26 wt.%, about 17 to about 23 wt.%; from about 21 to about 40 wt.%, about21 to about 36 wt.%, about 21 to about 32 wt.%, about 21 to about 29 wt.%, about 21 to about26 wt.%; from about 25 to about 40 wt.%, about 25 to about 36 wt.%, about 25 to about 32 wt.%, about 25 to about 29 wt.%; from about 28 to about 40 wt.%, about 28 to about 36 wt.%, about 28 to about 32 wt.%; from about 31 to about 40 wt.%, about 31 to about 36 wt.%, or any range or subrange thereof, based on the total weight of the skin care composition.

[0070] In other embodiments, the fatty component may be present in an amount from about 30 to about 70 wt.%, based on the total weight of the skin care composition. For example, the fatty component, which may comprise or consist of one or more fatty ester, one or more fatty alcohol, one or more a fatty ether, one or more oil, and / or one or more wax, may be present in an amount from about 30 to about 70 wt.%, about 30 to about 60 wt.%, about 30 to about 55 wt.%, about 30 to about 50 wt.%, about 30 to about 45 wt.%; from about 40 to about 70 wt.%, about 40 to about 60 wt.%, about 40 to about 55 wt.%, about 40 to about 50 wt.%; from about 45 to about 70 wt.%, about 45 to about 60 wt.%, about 45 to about 55 wt.%; from about 50 to about 70 wt.%, about 50 to about 60 wt.%, or any range or subrange thereof, based on the total weight of the skin care composition.

[0071] The fatty compounds may include or be chosen from one or more oil(s). The term “oil” means any fatty substance that is in liquid form at room temperature (24-25 °C) and at atmospheric pressure (760 mmHg). The oil may be a non-silicone oil and / or a hydrocarbon-based oil, including but not limited to, a saturated hydrocarbon oil, an unsaturated hydrocarbon oil, lipids, triglycerides, a natural oil, and / or a synthetic oil. The one or more oil(s) may be synthetic oils and / or plant-based oils. For instance, the oil may be a synthetic oil, such as a mineral oil and / or an alkane (paraffins).Docket No. 863910-00-WO-01-SHLight (low viscosity) highly branched hydrocarbon oils may also be suitable in some instances. For example, the skin care composition may include an oil, such as isododccanc, isodccanc, decane, dodecane, C11-13 isoalkane, or a combination of two or more thereof. In at least one embodiment, the skin care composition comprises one or more non-silicone oil selected from the group consisting of isododecane, isodecane, decane, dodecane, C11-13 isoalkane, and a combination of two or more thereof.

[0072] In some embodiments, the oil is chosen from plant-based or vegetable-based oils, such as coconut oil, soybean oil, canola oil, rapeseed oil, com oil, cottonseed oil, olive oil, palm oil, peanut oil, safflower oil, sesame oil, sunflower seed oil, linseed oil, palm kernel oil, tung oil, jatropha oil, mustard oil, camelina oil, pennycress oil, castor oil, wheatgerm oil, apricot kernel oil, pistachio oil, poppy oil, pine oil, avocado oil, hazel nut oil, grapeseed oil, colza oil, cade oil, peach kernel oil, coffee bean oil, jojoba oil, and a mixture thereof. In at least one embodiment, the oil(s) are selected from a plant-based oil chosen from sunflower oil, corn oil, rosa moschata seed oil, soybean oil, marrow oil, hydrogenated vegetable oil, grapeseed oil, sesame seed oil, hazelnut oil, apricot oil, macadamia oil, arara oil, castor oil, avocado oil, caprylic / capric acid triglycerides, jojoba oil and shea butter oil, and a combination of two or more thereof. In at least one embodiment, the skin care composition comprises a plant-based oil comprising or consisting of hydrogenated olive oil unsaponifiables, and hydrogenated ethylhexyl olivate, or a combination of two or more thereof. In at least one preferred embodiment, the oil comprises or consists of sunflower seed oil. The sunflower seed oil may comprise 90 wt.% or more, e.g., 95 wt.% or more or 98 wt.% or more, of the fatty component, based on the total weight of the fatty component.

[0073] The non-silicone oil may be present in the skin care composition in an amount from about 0.5 to about 8 wt.%, based on the total weight of the skin care composition. For example, the non- silicone oil may be present in an amount from about 0.5 to about 6 wt.%, about 0.5 to about 4 wt.%, about 0.5 to about 3 wt.%, about 0.5 to about 2 wt.%, about 0.5 to about 1 wt.%; from about 1 to about 8 wt.%, about 1 to about 6 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%, about 1 to about 2 wt.%; from about 2 to about 8 wt.%, about 2 to about 6 wt.%, about 2 to about 5 wt.%, about 2 to about 4 wt.%; from about 3 to about 8 wt.%, about 3 to about 6 wt.%; from about 4 to about 9 wt.%, about 4 to about 8 wt.%, about 4 to about 7 wt.%, or about 4 to about 6 wt.%, including any range or subrange therebetween, based on the total weight of the skin care composition.Docket No. 863910-00-WO-01-SH

[0074] The oil may be a silicone oil, such as a volatile or nonvolatile, cyclic, linear or branched silicone oil, which may be unmodified or modified with organic groups. The silicone oil may be chosen from polydialkylsiloxanes, such as polydimethylsiloxanes (PDMS), and liquid polyorganosiloxanes. In some cases, the silicone oil may be selected from polydialkylsiloxanes, octamethylcyclotetrasiloxane, tetra(trimethylsilyl)pentaerythritol, octamethylcyclotetrasiloxane, polydiphenylsiloxanes, poly alkylarylsiloxanes, dimethicone, cyclopentasiloxane, poly silicone- 11, or a combination of two or more thereof. Skin compatible oils may be silicone based, for example, linear and cyclic polydimethyl siloxane, organo functional silicones (alkyl and alkyl aryl), and amino silicones. In at least one embodiment, the skin care composition includes one or more silicone comprising or consisting of dimethicone, cyclopentasiloxane, and / or polysilicone-11.

[0075] The silicone oil(s) may be present in the skin care composition may be from about 1.5 to about 17 wt.%, based on the total weight of the skin care composition. For example, the silicone oil(s) may be present in an amount from about 1.5 to about 17 wt.%, about 1.5 to about 14 wt.%, about 1.5 to about 11 wt.%, about 1.5 to about 9 wt.%, about 1.5 to about 7 wt.%; from about 3 to about 17 wt.%, about 3 to about 14 wt.%, about 3 to about 11 wt.%, about 3 to about 9 wt.%, about 3 to about 7 wt.%; from about 5 to about 17 wt.%, about 5 to about 14 wt.%, about 5 to about 11 wt.%, about 5 to about 9 wt.%; from about 7 to about 17 wt.%, about 7 to about 14 wt.%, about 7 to about 11 wt.%; from about 9 to about 17 wt.%, about 9 to about 14 wt.%, about 9 to about 12 wt.%; from about 11 to about 17 wt.%, about 11 to about 14 wt.%, or any range or subrange thereof, based on the total weight of the skin care composition.

[0076] The fatty component may comprise a fatty ester, such as those chosen from stearyl stearate, dihydroabietyl behenate, octyldodecyl behenate, isocetyl behenate, isostearyl lactate, lauryl lactate, linoleyl lactate, oleyl lactate, isostearyl octanoate, isocetyl octanoate, octyl octanoate, decyl oleate, isocetyl isostearate, isocetyl laurate, isocetyl stearate, isodecyl octanoate, isodecyl oleate, isononyl isononanoate, isostearyl palmitate, methyl acetyl ricinoleate, octyl isononanoate, 2-ethylhexyl isononanoate, octyldodecyl erucate, oleyl erucate, ethyl palmitate, isopropyl palmitate, such as 2-ethylhexyl palmitate, 2-octyldecyl palmitate, alkyl myristates such as isopropyl 2-octyldodecyl myristate, isobutyl stearate, 2-hexyldecyl laurate, isocetyl stearate, octyldodecyl stearoyl stearate, or a combination thereof. The fatty esters may comprise or consist of isoamyl laurate, ethyl linoleate, ethylhexyl stearate, coco-caprylate / caprate, isoamyl cocoate, glyceryl stearate, PEG- 100 stearate, polyglyceryl-10 dipalmitate, polyglyceryl-10 dioleate, and / orDocket No. 863910-00-WO-01-SH a combination of two or more thereof.

[0077] The fatty cstcr(s) may be present in the skin care composition in an amount from about 0.5 to about 8 wt.%, based on the total weight of the skin care composition. For example, fatty ester(s) may be present in an amount from about 0.5 to about 6 wt.%, about 0.5 to about 4 wt.%, about 0.5 to about 3 wt.%, about 0.5 to about 2 wt.%, about 0.5 to about 1 wt.%; from about 1 to about 8 wt.%, about 1 to about 6 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%, about 1 to about 2 wt.%; from about 2 to about 8 wt.%, about 2 to about 6 wt.%, about 2 to about 5 wt.%, about 2 to about 4 wt.%; from about 3 to about 8 wt.%, about 3 to about 6 wt.%; from about 4 to about 9 wt.%, about 4 to about 8 wt.%, about 4 to about 7 wt.%, or about 4 to about 6 wt.%, including any range or subrange therebetween, based on the total weight of the skin care composition.

[0078] The fatty component may comprise one or more fatty alcohol(s). The fatty alcohol may be chosen from linear or branched, saturated or unsaturated alcohols, preferably unsaturated or branched alcohols, comprising from 6 to 40 carbon atoms, preferably from 8 to 30 carbon atoms. Examples of fatty alcohols include cetyl alcohol, stearyl alcohol, cetearyl alcohol, lauric alcohol, octyldodecanol, 2-butyloctanol, 2-hexyldecanol, 2-undecylpentadecanol, isostearyl alcohol, oleyl alcohol, linolenyl alcohol, ricinoleyl alcohol, undecylenyl alcohol and linoleyl alcohol, and a combination of two or more thereof. In at least one embodiment, the fatty alcohols are chosen from cetyl alcohol, stearyl alcohol, cetearyl alcohol, lauric alcohol, and / or a mixture of two or more thereof.

[0079] The fatty alcohol(s) may be present in the skin care composition in an amount from about 0.1 to about 6 wt.%, based on the total weight of the skin care composition. For example, fatty alcohol(s) may be present in an amount from about 0.1 to about 4 wt.%, about 0.1 to about 3 wt.%, about 0.1 to about 2 wt.%, about 0.1 to about 1 wt.%; from about 0.5 to about 4 wt.%, about 0.5 to about 3 wt.%, about 0.5 to about 2 wt.%, about 0.5 to about 1 wt.%; from about 1 to about 8 wt.%, about 1 to about 6 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%, about 1 to about 2 wt.%; from about 2 to about 8 wt.%, about 2 to about 6 wt.%, about 2 to about 5 wt.%, about 2 to about 4 wt.%; from about 3 to about 8 wt.%, about 3 to about 6 wt.%; from about 4 to about 9 wt.%, about 4 to about 8 wt.%, about 4 to about 7 wt.%, or about 4 to about 6 wt.%, including any range or subrange therebetween, based on the total weight of the skin care composition.

[0080] The skin care composition may include one or more skin conditioning agent(s), such as aloe vera extract, allantoin, licorice extract, glycyrrhizin, or combinations thereof. In someDocket No. 863910-00-WO-01-SH embodiments, the soothing agents may be selected from natural extracts comprising: centella asiatica extract, polygonum cuspidatum root extract, Scutellaria baicalcnsis root extract, camellia sinensis leaf extract, syringa vulgaris leaf cell culture extract, bakuchiol, hydrogenated olive oil unsaponifiables, hydrogenated ethylhexyl olivate, dipotassium glycyrrhizinate, glycyrrhiza glabra (licorice) root extract, chamomilla recutita (matricaria) flower extract, rosmarinus officinalis (rosemary) leaf extract, tea (camellia sinensis) leaf extract, poria cocos extract, phragmites karka extract, lidocaine, chia seed extract, Rosa centifolia flower extract, aloe vera, allantoin, D- panthenol, turmeric, avocado oil, lichen extract, or a combination of two or more thereof. In at least one embodiment, the one or more skin conditioning agent(s) may comprise or consist of syringa vulgaris leaf cell culture extract, dipotassium glycyrrhizinate, bakuchiol, hydrogenated olive oil unsaponifiables, hydrogenated ethylhexyl olivate, and / or a combination of two or more thereof. One or more of the foregoing soothing agents may be excluded from the skin care composition in certain embodiments. In at least one embodiment, the skin care composition is free of allantoin and, optionally, one or more or all of the foregoing skin soothing agents.

[0081] The amount of the one or more skin conditioning agent(s) in the skin care composition may be about 0.01 to about 7 wt.%, based on the total weight of the skin care composition. In some instances, the skin care composition may be formulated to have skin conditioning agents(s) present in a total amount of about 0.01 to about 5 wt.%, about 0.01 to about 3 wt.%, about 0.01 to about 2 wt.%, about 0.01 to about 1 wt.%, about 0.01 to about 0.75 wt.%, about 0.01 to about 0.5 wt.%, about 0.01 to about 0.25 wt.%, about 0.01 to about 0.1 wt.%; from about 0.05 to about 7 wt.%, about 0.05 to about 5 wt.%, about 0.05 to about 3 wt.%, about 0.05 to about 2 wt.%, about 0.05 to about 1 wt.%, about 0.05 to about 0.75 wt.%, about 0.05 to about 0.5 wt.%, about 0.05 to about 0.25 wt.%, about 0.05 to about 0.1 wt.%; from about 0.1 to about 7 wt.%, about 0.1 to about 5 wt.%, about 0.1 to about 3 wt.%, about 0.1 to about 2 wt.%, about 0.1 to about 1 wt.%, about 0.1 to about 0.75 wt.%, about 0.1 to about 0.5 wt.%, about 0.1 to about 0.25 wt.%; from about 0.15 to about 7 wt.%, about 0.15 to about 5 wt.%, about 0.15 to about 3 wt.%, about 0.15 to about 2 wt.%, about 0.15 to about 1 wt.%, about 0.15 to about 0.75 wt.%, about 0.15 to about 0.5 wt.%, about 0.15 to about 0.25 wt.%; from about 0.4 to about 7 wt.%, about 0.4 to about 5 wt.%, about 0.4 to about 3 wt.%, about 0.4 to about 2 wt.%, about 0.4 to about 1 wt.%, about 0.4 to about 0.75 wt.%; from about 0.8 to about 7 wt.%, about 0.8 to about 5 wt.%, about 0.8 to about 3 wt.%, about 0.8 to about 2 wt.%, about 0.8 to about 1 wt.%; from about 1.2 to about 7 wt.%, about 1.2 to about 5Docket No. 863910-00-WO-01-SH wt.%, about 1 .2 to about 3 wt.%, about 1 .2 to about 2 wt.%; from about 1 .6 to about 7 wt.%, about 1.6 to about 5 wt.%, about 1.6 to about 3 wt.%, about 1.6 to about 2 wt.%; from about 2 to about 7 wt.%, about 2 to about 5 wt.%, about 2 to about 3 wt.%, or any range or subrange thereof, based on the total weight of the skin care composition.

[0082] In addition to skin conditioning agents, the skin care compositions may comprise one or more peptide(s) in an amount typically up to 0.5 wt.%, based on the total weight of the skin care composition. For instance, the skin care composition may include a total amount of peptides from about 0.001 to 0.5 wt.%, about 0.001 to about 0.3 wt.%, about 0.001 to about 0.1 wt.%, about 0.001 to about 0.08 wt.%, about 0.001 to about 0.05 wt.%, about 0.001 to about 0.01 wt.%; from about 0.001 to 0.5 wt.%, about 0.001 to about 0.3 wt.%, about 0.001 to about 0.1 wt.%, about 0.001 to about 0.08 wt.%, about 0.001 to about 0.05 wt.%, about 0.001 to about 0.01 wt.%; from about 0.005 to 0.5 wt.%, about 0.005 to about 0.3 wt.%, about 0.005 to about 0.1 wt.%, about 0.005 to about 0.08 wt.%, about 0.005 to about 0.05 wt.%, about 0.005 to about 0.01 wt.%; from about 0.01 to 0.5 wt.%, about 0.01 to about 0.3 wt.%, about 0.01 to about 0.1 wt.%, about 0.01 to about 0.08 wt.%, about 0.01 to about 0.05 wt.%; from about 0.05 to 0.5 wt.%, about 0.05 to about 0.3 wt.%, about 0.05 to about 0.1 wt.%, about 0.05 to about 0.08 wt.%; from about 0.1 to 0.5 wt.%, about 0.1 to about 0.3 wt.%; from about 0.2 to 0.5 wt.%, about 0.2 to about 0.4 wt.%, about 0.3 to 0.5 wt.%, or any range or subrange thereof, based on the total weight of the skin care composition.

[0083] Examples of peptide(s) include tripeptide-29, acetyl tetrapeptide-2, trifluoroacetyl tripeptide-2, and myristoyl nonapeptide- 3. Preferably, the one or more peptides comprise or consist of myristoyl nonapeptide- 3. In some embodiments, the one or more peptide(s) consists of myristoyl nonapeptide-3 and one or more of tripeptide-29, acetyl tetrapeptide-2, or trilluoroacetyl tripeptide-2.

[0084] The skin care composition may include one or more polyol(s) in an amount that may vary depending on the form of the skin care composition and / or other components therein. The total amount of polyols in the skin care composition may be from about 0.5 to about 20%, based on the total weight of the skin care composition. For example, the total amount of polyol present in the skin care compositions may be from about 0.5 to about 15 wt.%, about 0.5 to about 10 wt.%, about 0.5 to about 8 wt.%, about 0.5 to about 6 wt.%, about 0.5 to about 4 wt.%; from about 1 to about 20 wt.%, about 1 to about 15 wt.%, about 1 to about 10 wt.%, about 1 to about 8 wt.%, about 1 to about 6 wt.%, about 1 to about 4 wt.%; from about 2 to about 20 wt.%, about 2 to about 15 wt.%,Docket No. 863910-00-WO-01-SH about 2 to about 10 wt.%, about 2 to about 8 wt.%, about 2 to about 6 wt.%, about 2 to about 4 wt.%; from about 4 to about 20 wt.%, about 4 to about 15 wt.%, about 4 to about 10 wt.%, about 4 to about 8 wt.%; from about 6 to about 20 wt.%, about 6 to about 15 wt.%, about 6 to about 10 wt.%, about 6 to about 8 wt.%; from about 9 to about 20 wt.%, about 9 to about 1 wt.%, about 9 to about 12 wt.%, from about 12 to about 20 wt.%, about 18 to about 15 wt.%, about 12 to about 15 wt.%, including ranges and subranges thereof, based on the total weight of the skin care composition.

[0085] The polyol(s) may be chosen from glycols or compounds with numerous hydroxyl groups. The term “polyol” should be understood as meaning, within the meaning of the present disclosure, an organic molecule comprising at least two free hydroxyl groups. The polyols of the skin care composition may be glycols or compounds with numerous hydroxyl groups. In some cases, the one or more polyol(s) is selected from the group consisting of C2-C32 polyols. The one or more polyols may have from 2 to 32 carbon atoms, from 3 to 16 carbon atoms, or from 3 to 12 carbon atoms. Polyols that may be included in the skin care composition, in certain instances, include ethylene glycol, propylene glycol, butylene glycol, caprylyl glycol hexylene glycol, glycerin, diglycerin, diethylene glycol, and dipropylene glycol, and mixtures thereof.

[0086] Non-limiting examples of polyols that may, optionally, be included in the skin care composition include and / or may be chosen from alkanediols such as glycerin, 1,2,6-hexanetriol, trimethylolpropane, ethylene glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, diethylene glycol, diethylene glycol, tetraethylene glycol, pentaethylene glycol, dipropylene glycol, 2-butene-l,4-diol, 2-ethyl-l,3-hexanediol, 2-methyl-2,4-pentanediol, caprylyl glycol, 1,2-hexanediol, 1,2-pentanediol, and 4-methyl-l,2-pentanediol; glycol ethers such as ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol monomethyl ether acetate, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol mono-n-propyl ether, ethylene glycol mono-iso-propyl ether, diethylene glycol mono-iso-propyl ether, ethylene glycol mono-n-butyl ether, ethylene glycol mono-t-butyl ether, diethylene glycol mono-t-butyl ether, 1 -methyl- 1-methoxybutanol, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol mono-t- butyl ether, propylene glycol mono-n-propyl ether, propylene glycol mono-iso-propyl ether, dipropylene glycol monomethyl ether, dipropylene glycol monoethyl ether, dipropylene glycolDocket No. 863910-00-WO-01-SH mono-n-propyl ether, dipropylene glycol mono-iso-propyl ether, sorbitol, sorbitan, triacetin, and a combination of two or more thereof.

[0087] The one or more polyols may, optionally, be glycols or glycol ethers such as, e.g., monomethyl, monoethyl and monobutyl ethers of ethylene glycol, propylene glycol or ethers thereof such as, e.g., monomethyl ether of propylene glycol, butylene glycol, caprylyl glycol, pentylene glycol, hexylene glycol, dipropylene glycol as well as alkyl ethers of diethylene glycol, e.g., monoethyl ether or monobutyl ether of diethylene glycol. In some cases, the one or more polyols may include or are chosen from ethylene glycol, propylene glycol, butylene glycol, caprylyl glycol, hexylene glycol, pentylene glycol, 1,3-propanediol, diethylene glycol, dipropylene glycol, 1 ,4-butanediol, 1,5-pentanediol, hexane- 1,6-diol, glycerin, diglycerin, caprylyl glycol, and a mixture thereof. Non-limiting examples of polyols that may be included in the skin care composition, in certain instances, include ethylene glycol, propylene glycol, butylene glycol, caprylyl glycol, hexylene glycol, diglycerin, diethylene glycol, and dipropylene glycol, and a combination of two or more thereof.

[0088] The skin care composition may include one or more polyol(s) that are humectants. The humectants may be selected from the polyols disclosed above. Further, examples of humectants that may be incorporated in certain embodiments include triethylene glycol, tripropylene glycol, propylene glycol, caprylyl glycol, glycerin, polyethylene glycols, polypropylene glycol, glycerin, sorbitol, hexylene glycol, butylene glycol, hyaluronic acid, 1,2 hexanediol, saccharide isomerate and a combination of two or more thereof.

[0089] The skin care composition may comprise water in an amount from about 20 wt.% to about 60 wt.%, based on the total weight of the skin care composition. In some embodiments, the skin care composition has from about 20 wt.% to about 60 wt.%, about 20 wt.% to about 55 wt.%, about 20 wt.% to about 50 wt.%, about 20 wt.% to about 45 wt.%, about 20 wt.% to about 40 wt.%, about 20 wt.% to about 35 wt.%; from about 30 wt.% to about 60 wt.%, about 30 wt.% to about 55 wt.%, about 30 wt.% to about 50 wt.%, about 30 wt.% to about 45 wt.%, about 30 wt.% to about 40 wt.%; from about 35 wt.% to about 60 wt.%, about 35 wt.% to about 55 wt.%, about 35 wt.% to about 50 wt.%, about 35 wt.% to about 45 wt.%; from about 40 wt.% to about 60 wt.%, about 40 wt.% to about 55 wt.%; from about 45 wt.% to about 60 wt.%, about 45 wt.% to about 55 wt.%, about 50 wt.% to about 60 wt.%, or any range or subrange thereof, based on the total weight of the skin care composition. In some cases, the skin care composition comprises water inDocket No. 863910-00-WO-01-SH an amount from about 20 to about 50 wt.%, about 20 to about 45 wt.%, about 20 to about 40 wt.%, about 20 to about 35 wt.%; from about 25 to about 50 wt.%, about 25 to about 45 wt.%, about 25 to about 40 wt.%, about 22 to about 35 wt.%; from about 30 to about 50 wt.%, about 30 to about 45 wt.%, about 30 to about 40 wt.%; from about 35 to about 50 wt.%, about 35 to about 45 wt.%, or any range or subrange thereof, based on the total weight of the skin care composition.

[0090] As mentioned above, the skin care compositions generally have a pH of about 4.75 to about 6.7, about 4.75 to about 6.5, about 4.75 to about 6.3, about 4.75 to about 6.1, about 4.75 to about 5.9; about 5 to about 6.7, about 5 to about 6.5, about 5 to about 6.3, about 5 to about 6.1, about 5 to about 5.9; about 5.25 to about 6.7, about 5.25 to about 6.5, about 5.25 to about 6.3, about 5.25 to about 6.1, about 5.25 to about 5.9; about 5.5 to about 6.7, about 5.5 to about 6.5, about 5.5 to about 6.3, about 5.5 to about 6.1, about 5.5 to about 5.9; from about 5.7 to about 6.7, about 5.7 to about 6.5, about 5.7 to about 6.3, about 5.7 to about 6.1, about 5.7 to about 5.9; from about 5.9 to about 6.7, about 5.9 to about 6.5, about 5.9 to about 6.3; from about 6.1 to about 6.7, about 6.1 to about 6.5, about 6.3 to about 6.7, or any range or subrange thereof. In certain preferred embodiments, the skin care composition has a pH of about 4.75 to about 6.3, about 5 to about 6.3, or about 5 to about 6.

[0091] The skin care composition may include one or more pH adjusters to increase or decrease the overall pH of the skin care composition. For example, one or more acids may be included to decrease the pH of the skin care composition. Examples of suitable acids for decreasing the pH of the skin care composition include, but are not limited to, citric acid, acetic acid, and the like. The skin care composition may include one or more bases, such as sodium hydroxide, potassium hydroxide and the like, to increase the pH of the skin care composition. Additional or alternative acids and bases that are suitable for adjusting the pH of the skin care composition are readily known to one of ordinary skill in the art.

[0092] The amount of the pH adjuster in the skin care composition may be based on the desired pH of the final skin care composition and / or product. For example, the total amount of the pH adjuster may range from about 0.05 to about 5 wt.%, based on the total weight of the skin care composition. In some instances, the total amount of pH adjuster is from about 0.05 to about 3 wt.%, about 0.1 to about 2 wt.%, about 0.1 to about 1 wt.%, about 0.2 to about 0.9 wt.%, about 0.4 to about 1.6 wt.%, about 0.4 to about lwt.%, about 0.5 to about 2, about 0.5 to about 1.5, including ranges and sub-ranges therebetween, based on the total weight of the skin care composition. InDocket No. 863910-00-WO-01-SH certain preferred embodiments, the skin care composition includes sodium hydroxide in an amount from about 0.1 to about 1 wt.%, about 0.3 to about 1 wt.%, about 0.4 to about 1 wt.%, about 0.5 to about 1 wt.%, about 0.6 to about 1 wt.%, about 0.3 to about 0.9 wt.%, about 0.4 to about 0.9 wt.%, about 0.5 to about 0.9 wt.%, about 0.6 to about 0.9 wt.%, or any range or subrange thereof, based on the total weigh to of the skin care composition. In at least one preferred embodiment, the skin care composition includes sodium hydroxide in an amount from about 0.4 to about 1 wt.% or about 0.5 to about 0.9 wt.%, based on the total weight of the skin care composition.

[0093] The skin care formulations may optionally comprise surfactants and / or emulsifying agents, wherein the surfactants and / or emulsifying agents include but are not limited to, ceteareths, ceteths, cetyl alcohol, deceths, dodoxynols, glyceryl palmitate, glyceryl stearate, laneths, myreths, nonoxynols, octoxynols, oleths, PEG-castor oil, poloxamers, poloxamines, polysorbates, ammonium laureth sulfate and sodium laureth sulfate, octoxynol-9 and polysorbate-20. For example, the skin care composition may include surfactants and / or emulsifying agents, such as trideceth-6, polysorbate 20, decyl glucoside, glyceryl stearate, and / or peg- 100 stearate. Additionally, the skin care composition may include emulsifiers chosen from natural emulsifiers, such as acacia, gelatin, lecithin and cholesterol; finely dispersed solids, such as colloidal clays, bentonite, magnesium aluminum silicate; and synthetic emulsifiers, such as salts of fatty acids, sulfates such as sorbitan trioleate, sorbitan tristearate, sucrose distearate, propylene glycol monostearate, glycerol monostearate, propylene glycol monolaurate, sorbitan monostearate, sorbitan monolaurate, poly oxy ethylene-4-lauryl ether, sodium lauryl sulfate, sulfonates such as dioctyl sodium sulfosuccinate, glyceryl esters, polyoxyethylene glycol esters and ethers, diethylene glycol monostearate, PEG 200 distearate, and sorbitan fatty acid esters, such as sorbitan monopalmitate, and their polyoxyethylene derivatives, polyoxyethylene glycol esters such as the monostearate, Polysorbate 80 (ethoxylated sorbitan monooleate) (supplied by Spectrum, etc ); and combinations of two or more thereof.

[0094] The total amount of surfactants may be from about 0.1 to about 8 wt.%, about 0.1 to about 6 wt.%, about 0.1 to about 4 wt.%, about 0.1 to about 3 wt.%, about 0.1 to about 2 wt.%, about 0.1 to about 1 wt.%; from about 0.5 to about 10 wt.%, about 0.5 to about 8 wt.%, about 0.5 to about 6 wt.%, about 0.5 to about 4 wt.%, about 0.5 to about 3 wt.%, about 0.5 to about 2 wt.%, about 0.5 to about 1 wt.%; from about 1 to about 10 wt.%, about 1 to about 8 wt.%, about 1 to about 6 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%, about 1 to about 2 wt.%; from about 2 to aboutDocket No. 863910-00-WO-01-SH10 wt.%, about 2 to about 8 wt.%, about 2 to about 6 wt.%, about 2 to about 5 wt.%, about 2 to about 4 wt.%; from about 3 to about 10 wt.%, about 3 to about 8 wt.%, about 3 to about 6 wt.%; from about 4 to about 10 wt.%, about 4 to about 9 wt.%, about 4 to about 8 wt.%, about 4 to about 7 wt.%, or about 4 to about 6 wt.%, including any range or subrange therebetween, based on the total weight of the skin care composition.

[0095] The total amount of emulsifying agents may be from about 0.1 to about 8 wt.%, about 0.1 to about 6 wt.%, about 0.1 to about 4 wt.%, about 0.1 to about 3 wt.%, about 0.1 to about 2 wt.%, about 0.1 to about 1 wt.%; from about 0.5 to about 10 wt.%, about 0.5 to about 8 wt.%, about 0.5 to about 6 wt.%, about 0.5 to about 4 wt.%, about 0.5 to about 3 wt.%, about 0.5 to about 2 wt.%, about 0.5 to about 1 wt.%; from about 1 to about 10 wt.%, about 1 to about 8 wt.%, about 1 to about 6 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%, about 1 to about 2 wt.%; from about 2 to about 10 wt.%, about 2 to about 8 wt.%, about 2 to about 6 wt.%, about 2 to about 5 wt.%, about 2 to about 4 wt.%; from about 3 to about 10 wt.%, about 3 to about 8 wt.%, about 3 to about 6 wt.%; from about 4 to about 10 wt.%, about 4 to about 9 wt.%, about 4 to about 8 wt.%, about 4 to about 7 wt.%, or about 4 to about 6 wt.%, including any range or subrange therebetween, based on the total weight of the skin care composition.

[0096] The skin care compositions, in certain embodiments, may preferably be formulated with a reduced amount or without certain surfactants. For example, the skin care compositions may in some cases be formulated with a reduced amount, being substantially free of, or free of anionic surfactants. In some embodiments, the skin care composition has about 1 wt.% or less, about 0.5 wt.% or less, about 0.1 wt.% or less, about 0.05 wt.% or less, or about 0.01 wt.% or less, of anionic surfactants. The skin care compositions may, in some cases, preferably have a reduced amount, being substantially free of, or free of amphoteric surfactants. In some embodiments, the skin care composition has about 1 wt.% or less, about 0.5 wt.% or less, about 0.1 wt.% or less, about 0.05 wt.% or less, or about 0.01 wt.% or less, of amphoteric surfactants. Additionally, the skin care compositions may preferably be formulated with a reduced amount, being substantially free of, or free of cationic surfactants. In some embodiments, the skin care composition has about 1 wt.% or less, about 0.5 wt.% or less, about 0.1 wt.% or less, about 0.05 wt.% or less, or about 0.01 wt.% or less, of cationic surfactants.

[0097] In certain embodiments, the skin care compositions include one or more thickening agent(s). The skin care compositions may include a total amount of thickening agents ranging fromDocket No. 863910-00-WO-01-SH about 0.1 to about 10 wt.%, based on the total weight of the skin care composition. For instance, the thickening agcnt(s) may be present in the skin care compositions in an amount ranging from about 0.1 to about 8 wt.%, about 0.1 to about 6 wt.%, about 0.1 to about 4 wt.%, about 0.1 to about 3 wt.%, about 0.1 to about 2 wt.%, about 0.1 to about 1 wt.%; from about 0.5 to about 10 wt.%, about 0.5 to about 8 wt.%, about 0.5 to about 6 wt.%, about 0.5 to about 4 wt.%, about 0.5 to about 3 wt.%, about 0.5 to about 2 wt.%, about 0.5 to about 1 wt.%; from about 1 to about 10 wt.%, about 1 to about 8 wt.%, about 1 to about 6 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%, about 1 to about 2 wt.%; from about 2 to about 10 wt.%, about 2 to about 8 wt.%, about 2 to about 6 wt.%, about 2 to about 5 wt.%, about 2 to about 4 wt.%; from about 3 to about 10 wt.%, about 3 to about 8 wt.%, about 3 to about 6 wt.%; from about 4 to about 10 wt.%, about 4 to about 9 wt.%, about 4 to about 8 wt.%, about 4 to about 7 wt.%, or about 4 to about 6 wt.%, including any ranges or subranges thereof, based on the total weight of the skin care composition.

[0098] The thickening agent may comprise or consist of sodium polyacryloyldimethyl taurate (e.g., ammonium acryloyldimethyltaurate / VP copolymer), polyacrylate crosspolymers (e.g., sodium polyacrylate) or crosslinked polyacrylate polymers (other than crosslinked sodium polyacrylate), cationic acrylate copolymers, anionic acrylic or carboxylic acid polymers, polyacrylamide polymers, polysaccharides such as cellulose derivatives, gums, polyquaterniums, vinylpyrrolidone homopolymers / copolymers, CH-24 hydroxyl substituted aliphatic acid, Cs-24 conjugated aliphatic acid, sugar fatty esters, polyglyceryl esters, and a mixture of two or more thereof. The thickening agents may be chosen from xanthan gum, guar gum, biosaccharide gum, cellulose, acacia seneca gum, sclerotium gum, agarose, pechtin, gellan gum, hyaluronic acid, and a combination of two or more thereof. Additionally, the thickening agents may include polymeric thickeners selected from the group consisting of ammonium polyacryloyldimethyl taurate, ammonium acryloyldimethyltaurate / VP copolymer, acrylates copolymers, polyacrylamide, carbomer, acrylates / Cio-30 alkyl acrylate crosspolymer, and a combination of two or more thereof. In some embodiments, the skin care composition comprise or consist of ammonium acryloyldi methyltaurate / VP copolymer, sodium polyacrylate, xanthan gum, and / or a combination thereof. In further embodiments, the skin care composition include sodium polyacryloyldimethyl taurate or a derivative thereof and at least one additional thickening agent, such as hydroxypropyl methylcellulose, hexyllactone crosspolymer, and / or pullulan.Docket No. 863910-00-WO-01-SH

[0099] The skin care composition typically includes one or more vitamin C and / or a derivative thereof, c.g., in an amount from about 0.1 to about 6 wt.%, based on the total weight of the skin care composition. In some cases, the total amount of the one or more vitamin C and / or a derivative thereof is from about 0.1 to about 6 wt.%, about 0.1 to about 5 wt.%, about 0.1 to about 4 wt.%, about 0.1 to about 3 wt.%, about 0.1 to about 2 wt.%, about 0.1 to about 1 wt.%; from about 0.3 to about 6 wt.%, about 0.3 to about 5 wt.%, about 0.3 to about 4 wt.%, about 0.3 to about 3 wt.%, about 0.3 to about 2 wt.%, about 0.3 to about 1 wt.%; from about 0.5 to about 6 wt.%, about 0.5 to about 5 wt.%, about 0.5 to about 4 wt.%, about 0.5 to about 3 wt.%, about 0.5 to about 2 wt.%, about 0.5 to about 1.5 wt.%; from about 1 to about 6 wt.%, about 1 to about 5 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%, about 1 to about 2 wt.%; from about 2 to about 6 wt.%, about 2 to about 5 wt.%, about 2 to about 4 wt.%, about 2 to about 3 wt.%; from about 3 to about 6 wt.%, about 3 to about 5 wt.%, about 4 to about 6 wt.%, or any range or subrange thereof, based on the total weight of the skin care composition.

[0100] Vitamin C and / or derivatives thereof generally refers to ascorbic acid or derivatives thereof. Ascorbic acid exists as two enantiomers commonly denoted “L” (for “levo”) and “D” (for “dextro”). Ascorbic acid is also referred to as L(+)-ascorbic acid or L-ascorbic acid. The ascorbic acid derivatives may be or include, but are not limited to, L-ascorbic acid, calcium ascorbate, calcium L-ascorbate dihydrate, magnesium ascorbate, potassium ascorbate, magnesium L- ascorbyl phosphate (also referred to as: magnesium ascorbate phosphate or ascorbic acid phosphate magnesium salt), L-ascorbic acid 2-phosphate sesquimagnesium salt hydrate, (+) sodium L-ascorbate, dehydro-L-(+)-ascorbic acid dimer, sodium ascorbyl phosphate (also referred to as: ascorbic acid phosphate sodium salt, sodium L-ascorbyl phosphate, 2-phospho-L-ascorbic acid trisodium salt, L-ascorbic acid 2-phosphate trisodium salt or sodium L-ascorbyl-2-phosphate), ascorbic acid-2-glucoside, ascorbyl dipalmitate, ascorbyl methylsilanol pectinate, ascorbyl stearate, disodium ascorbyl sulfate, ascorbyl 6-palmitate, calcium ascorbyl phosphate, ascorbyl acetate, ascorbyl propionate, ascorbyl stearate, ascorbyl palmitate, ascorbyl dipalmitate, ascorbyl glucoside, ascorbic acid polypeptide, ethyl ascorbyl ether, ascorbyl ethyl silanol pectinate, or the like, or combinations thereof.

[0101] In some embodiments, the one or more vitamin C and / or derivative thereof may comprise or consists of L-ascorbic acid, calcium ascorbate, calcium L-ascorbate dihydrate, magnesium ascorbate, potassium ascorbate, magnesium L-ascorbyl phosphate, L-ascorbic acid 2-phosphateDocket No. 863910-00-WO-01-SH sesquimagnesium salt hydrate, (+) sodium L-ascorbate, dehydro-l-(+)-ascorbic acid dimer, sodium ascorbyl phosphate, ascorbic acid-2-glucosidc, ascorbyl dipalmitatc, ascorbyl mcthylsilanol pectinate, ascorbyl stearate, disodium ascorbyl sulfate, ascorbyl 6-palmitate, calcium ascorbyl phosphate, ascorbyl acetate, ascorbyl propionate, ascorbyl stearate, ascorbyl palmitate, ascorbyl dipalmitate, ascorbyl glucoside, ascorbic acid polypeptide, ethyl ascorbyl ether, ascorbyl ethyl silanol pectinate, or a combination of two or more thereof. In at least one embodiment, the vitamin C and / or derivative comprises or consists of an ascorbyl phosphate, such as sodium ascorbyl phosphate.

[0102] The skin care composition may include an additional organic acid and / or salt thereof, optionally, in an amount from about 0.5 to about 20 wt.%, based on the total weight of the skin care composition. The additional organic acid and / or salt thereof generally refer to organic acids and / or salts thereof other than those of salicylic acid, vitamin C, derivatives thereof, and / or salts thereof. In some embodiments, the total amount of additional organic acid(s) is from about 0.5 to about 16 wt.%, about 0.5 to about 12 wt.%, about 0.5 to about 8 wt.%, about 0.5 to about 5 wt.%; from about 1 to about 20 wt.%, about 1 to about 16 wt.%, about 1 to about 12 wt.%, about 1 to about 8 wt.%, about 1 to about 5 wt.%; from about 2 to about 20 wt.%, about 2 to about 16 wt.%, about 2 to about 12 wt.%, about 2 to about 8 wt.%, about 2 to about 5 wt.%; from about 5 to about 20 wt.%, about 5 to about 16 wt.%, about 5 to about 12 wt.%, about 5 to about 8 wt.%; from about 8 to about 20 wt.%, about 8 to about 16 wt.%, about 8 to about 12 wt.%; from about 11 to about 20 wt.%, about 11 to about 16 wt.%; from about 14 to about 20 wt.%, about 14 to about 17 wt.%, about 0.5 to about 12 wt.%, about 0.5 to about 8 wt.%, about 0.5 to about 5 wt.%, about 16 to about 20 wt.%, or any range or subrange thereof, based on the total weight of the skin care composition.

[0103] The additional organic acid may comprise organic acids having C2-18 alkyl chains (e.g., C2- 12 alkyl chains, C2-8 alkyl chains, C2-6 alkyl chains, Ce-18 alkyl chains, Cio-18 alkyl chains, and / or Ce- 12 alkyl chains), alpha hydroxy acids, beta hydroxy acids, a salt thereof, and a combination of two or more thereof. In some cases, the additional organic acid is selected from the group consisting of alpha hydroxy acids, beta hydroxy acids, a salt thereof, and a combination of two or more thereof.

[0104] The additional organic acid and / or salt thereof may comprise or consist of an alpha hydroxy acid, such as a C3 to C7 alpha-hydroxy acid or C4 to C<, alpha-hydroxy acid, and / or a salt thereof.Docket No. 863910-00-WO-01-SHNon-limiting examples of alpha hydroxy acids include but are not limited to, mandelic acid, glycolic acid, citric acid, lactic acid, malic acid, tartaric acid, phytic acid, hydroxycaprylic acid, hydroxycapric acid, glutaric acid, gluconic acid, or a combination of two or more thereof. For instance, the alpha hydroxy acid and / or salt thereof may be selected from mandelic acid, glycolic acid, citric acid, lactic acid, malic acid, tartaric acid, phytic acid, hydroxycaprylic acid, hydroxycapric acid, glutaric acid, gluconic acid, a salt thereof, and a combination of two or more thereof. In some embodiments, the alpha hydroxy acids are chosen from citric acid, mandelic acid, glycolic acid, lactic acid or a combination of two or more thereof. In certain instances, the alphahydroxy acid is selected from malic acid, tartaric acid, alpha-hydroxy glutaric acid, gluconic acid, a salt thereof, and a combination of two or more thereof. Yet in further instances, the alpha-hydroxy acid or salt thereof is selected from lactic acid, malic acid, sodium-D-gluconate, and a combination thereof. In at least one embodiment, the alpha hydroxy acid is lactic acid. In some embodiments, the skin care composition includes a salt of an alpha-hydroxy acid. The salt of the alpha-hydroxy acid is preferably a sodium salt or a potassium salt. In at least one embodiment, the salt is a sodium salt (i.e., the cation associated with the salt is a sodium).

[0105] The alpha hydroxy acid(s) may be present in an amount from about 0.5 to about 10 wt.%, based on the total weight of the skin care composition. For example, the amount of alpha hydroxy acid present in the skin care composition may be from about 0.5 to about 10 wt.%, about 0.5 to about 7 wt.%, about 0.5 to about 5 wt.%, about 0.5 to about 3 wt.%, about 0.5 to about 2 wt.%; from about 1 to about 10 wt.%, about 1 to about 7 wt.%, about 1 to about 5 wt.%, about 1 to about 3 wt.%, about 1 to about 2 wt.%; from about 2 to about 10 wt.%, about 2 to about 7 wt.%, about 2 to about 5 wt.%, about 2 to about 3 wt.%; from about 4 to about 10 wt.%, about 4 to about 7 wt.%; from about 6 to about 10 wt.%, about 6 to about 8 wt.%, or any range or subrange thereof, based on the total weight of the skin care composition.

[0106] In some embodiments, the additional organic acid and / or salt thereof may comprise one or more beta hydroxy acid(s). Non-limiting examples of beta hydroxy acids include propionic acid, beta-hydroybutyric acid, beta-hydroxy beata-methylbutyric acid, carnitine, and combinations of two or more thereof. The beta hydroxy acids may in some cases be selected from beta hydroxybutanoic acid, tropic acid, trethocanic acid, beta hydroxyl acids obtained from white willow bark extract and / or Wintergreen leaves, and combinations of two or more thereof. In someDocket No. 863910-00-WO-01-SH embodiments, the beta hydroxy acid(s) comprises beta hydroxyl acids of willow bark extract or combinations thereof.

[0107] The beta hydroxy acid(s) may be present in an amount from about 0.5 to about 10 wt.%, based on the total weight of the skin care composition. For example, the amount of alpha hydroxy acid present in the skin care composition may be from about 0.5 to about 10 wt.%, about 0.5 to about 7 wt.%, about 0.5 to about 5 wt.%, about 0.5 to about 3 wt.%, about 0.5 to about 2 wt.%; from about 1 to about 10 wt.%, about 1 to about 7 wt.%, about 1 to about 5 wt.%, about 1 to about 3 wt.%, about 1 to about 2 wt.%; from about 2 to about 10 wt.%, about 2 to about 7 wt.%, about 2 to about 5 wt.%, about 2 to about 3 wt.%; from about 4 to about 10 wt.%, about 4 to about 7 wt.%; from about 6 to about 10 wt.%, about 6 to about 8 wt.%, or any range or subrange thereof, based on the total weight of the skin care composition.

[0108] The skin care compositions may, also or alternatively, be formulated to have a weight ratio of beta hydroxy acid to alpha hydroxy acid is from about 5:1 to about 1:2, about 4:1 to about 1:2, about 3: 1 to about 1 :2, about 2: 1 to about 1 :2, about 1 : 1 to about 1 :2; from about 5:1 to about 1:1, about 4: 1 to about 1 :1, about 3: 1 to about 1 : 1, about 2: 1 to about 1 : 1; from about 5: 1 to about 2: 1, about 4:1 to about 2:1, about 3:1 to about 2:1, or any range or subrange thereof.

[0109] Additional ingredients may be present in the skin care composition. These include ingredients to thicken, preserve, emulsify, add fragrance, and color. The skin care compositions may include any of the following additional ingredients in an amount of from about 0.01 to about 5 wt.%. In some instances, the amount of additional ingredients present in the skin care composition is from about 0.01 to about 4 wt.%, about 0.01 to about 3 wt.%, about 0.01 to about 2 wt.%, about 0.01 to about 1 wt.%, about 0.01 to about 0.5 wt.%, about 0.01 to about 0.1 wt.%; about 0.1 to about 5 wt.%, about 0.1 to about 4 wt.%, about 0.1 to about 3 wt.%, about 0.1 to about 2 wt.%, about 0.1 to about 1 wt.%, about 0.1 to about 0.5 wt.%, about 0.1 to about 0.1 wt.%; about 0.5 to about 5 wt.%, about 0.5 to about 4 wt.%, about 0.5 to about 3 wt.%, about 0.5 to about 2 wt.%, about 0.5 to about 1 wt.%; about 0.75 to about 5 wt.%, about 0.75 to about 4 wt.%, about 0.75 to about 3 wt.%, about 0.75 to about 2 wt.%, about 0.75 to about 1 wt.%; about 1 to about 5 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%, about 1 to about 2 wt.%; about 2 to about 5 wt.%, about 2 to about 4 wt.%, about 2 to about 3 wt.%; about 3 to about 5 wt.%, about 3 to about 4 wt.%, including any range or subrange therebetween, based on the total weight of the skin care composition.Docket No. 863910-00-WO-01-SH

[0110] The skin care composition can comprise additional ingredients, such as vitamins (e.g., panthcnol, biotin, vitamin E acetate, vitamin A and D palmitate), amino acid-based surfactants, emollients (e.g., esters, isopropyl myristate, decyl oleate, C12-15 alkyl benzoate), as well as preservatives, dyes, fragrances, colorants, pearlizing agents, and chelating agents.

[0111] Non-limiting examples of fragrances and perfumes include odor compounds selected from: 7-acetyl-l,2,3,4,5,6,7,8-octahydro-l,l,6,7-tetramethylnaphthalene, a-ionone, P-ionone, y- ionone a-isomethy I ionone, methylcedrylone, methyl dihydrojasmonate, methyl 1,6,10-trimethyl- 2,5,9-cyclododecatrien-l-yl ketone, 7-acetyl-l,l,3,4,4,6-hexamethyltetralin, 4-acetyl-6-tert- buty 1-1,1 -dimethylindane, hydroxyphenylbutanone, benzophenone, methyl P-naphthyl ketone, 6- acetyl- 1 , 1 ,2,3,3,5-hexamethylindane, 5-acetyl-3-isopropyl- 1 , 1 ,2,6-tetramethylindane, 1- dodecanal, 4-(4-hydroxy-4-methylpentyl)-3-cyclohexene-l-carboxaldehyde, 7 -hydroxy-3, 7- dimethyloctanal, 10-undecen-l-al, isohexenylcyclohexylcarboxaldehyde, formyltricyclodecane, condensation products of hydroxycitronellal and methyl anthranilate, condensation products of hydroxycitronellal and indole, condensation products of phenylacetaldehyde and indole, 2- methyl-3-(para-tert-butylphenyl)propionaldehyde, ethylvanillin, heliotropin, hexylcinnamaldehyde, amylcinnamaldehyde, 2-methyl-2-(isopropylphenyl)propionaldehyde, coumarin, y-decalactone, cyclopentadecanolide, 16-hydroxy-9-hexadecenoic acid lactone, l,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-y-2-benzopyran, P-naphthol methyl ether, ambroxane, dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,lb]furan, cedrol, 5-(2,2,3- trimethylcyclopent-3-enyl)-3-methylpentan-2-ol, 2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-l-yl)- 2-buten-l-ol, caryophyllene alcohol, tricyclodecenyl propionate, tricyclodecenyl acetate, benzyl salicylate, cedryl acetate, and tert-butylcyclohexyl acetate.

[0112] Other fragrances may include odor compounds selected from essential oils, resinoids and resins from a large number of sources, such as, e.g., Peru balsam, olibanum resinoid, styrax, labdanum resin, nutmeg, cassia oil, benzoin resin, coriander, and lavandin.

[0113] Further suitable fragrances include odor compounds selected from phenylethyl alcohol, terpineol, linalool, linalyl acetate, geraniol, nerol, 2-(l,l-dimethylethyl)cyclo-hexanol acetate, benzyl acetate, and eugenol. The fragrances or perfumes can be used as single substances or in a mixture with one another.

[0114] The skin care composition may further comprise one or more colorants. The colorants may be a pigment, a dye, or mixtures thereof. Non-limiting examples of dyes include food dyes suitableDocket No. 863910-00-WO-01-SH for food, drug and cosmetic applications, and mixtures thereof. Some coloring agents (colorants) arc known as FD&C dyes. Non-limiting examples of pigments include titanium dioxide, zinc oxide, kaolin, mica, etc.

[0115] The colorants may be present in an amount ranging from about 0.0001 to about 0.4 wt.%, including all percentages and subranges therebetween, based on the total weight of the skin care composition. In some embodiments, the colorants may be present in an amount ranging from about 0.0001 to about 4 wt.%, including all percentages and subranges therebetween, based on the total weight of the skin care composition.

[0116] In certain embodiments, in order to prevent ingredients from separating, emulsifiers may be added. In certain embodiments, additional ingredients may include conditioning agents that moisturize the skin during and after use of the skin care composition. The emulsifier may be chosen from natural emulsifiers, such as acacia, gelatin, lecithin and cholesterol; finely dispersed solids, such as colloidal clays, bentonite, veegum (magnesium aluminum silicate; and synthetic emulsifiers, such as salts of fatty acids, sulfates such as sorbitan trioleate, sorbitan tri stearate, sucrose distearate, propylene glycol monostearate, glycerol monostearate, propylene glycol monolaurate, sorbitan monostearate, sorbitan monolaurate, poly oxy ethylene-4-lauryl ether, sodium lauryl sulfate, sulfonates such as dioctyl sodium sulfosuccinate, glyceryl esters, polyoxyethylene glycol esters and ethers, diethylene glycol monostearate, PEG 200 distearate, and sorbitan fatty acid esters, such as sorbitan monopalmitate, and their polyoxyethylene derivatives, polyoxyethylene glycol esters such as the monostearate, Polysorbate 80 (ethoxylated sorbitan monooleate) (supplied by Spectrum, etc.); and combinations of two or more thereof.

[0117] In other embodiments, the composition may include any of following materials in any desired amount to achieve a desired effect in the composition (amounts that can be used in some embodiments are provided): one or more alkaline salts, for example, sodium chloride, sodium sulfate, sodium carbonate, sodium bicarbonate and / or their equivalents (0 to 5% by weight); sequestrants, for example, tetrasodium EDTA, and / or their equivalents (0 to 2% by weight); biocides, for example, triclosan (2,4,4'-trichloro-2'-hydroxydiphenyl ether), DMDM hydantoin, formaldehyde and / or imidazolidinyl urea, and / or their equivalents (0 to 2% by weight); organic acids, for example, citric acid and / or formic acid and / or their equivalents (0 to 2% by weight); viscosity modifiers (0 to 2% by weight); fragrances and / or perfumes (0 to 5% by weight); preservatives, for example, potassium sorbate, phenoxyethanol, formaldehyde solution, parabens,Docket No. 863910-00-WD-01-SH pentanediol or sorbic acid (0 to 2% by weight); pearlizing agents, for example, glycol distearic esters, such as ethylene glycol distearate, but also fatty acid monoglycol esters (0 to 3% by weight); stabilizers, for example, metal salts of fatty acids, such as e.g. magnesium stearate, aluminum stearate and / or zinc stearate (0 to 2% by a weight); and dyes and pigments that are approved and suitable for cosmetic purposes.EXAMPLESExample 1

[0118] Four skin care compositions (Compositions Al, Al, Bl, and B2) were prepared in the form of a serum. The formulations for Compositions A1-B2 are shown in Table 1.Table 1Example 2

[0119] Compositions A1-B2 were evaluated to determine the stability of the retinol in each skin care composition. Specifically, samples of Compositions A1-B2 were assayed to determine theDocket No. 863910-00-WO-01-SH initial amount of retinol, the amount of retinol after 30 days of aging at room temperature, and the amount of retinol after 60 days of aging at room temperature. The samples were assayed using a HPLC with an isocratic pump and UV-Vis detector. A Cl 8 column was used with a mobile phase of 99 / 1 methanol / water and a flow rate of 1 mL / min. Samples were detected at 325 nm at a retention time of approximately 2.7 minutes. The stability of the samples was calculated as 100x(retinol level / baseline level).

[0120] Summaries of the amount of retinol after 30 days and after 60 days of aging are shown below in Tables 2 and 3. Specifically, Table 2 provides a summary of the amount of retinol after aging for Compositions A2 and B2, which had pHs of 4.5 and 4.4, respectively.Table 2

[0121] Table 3 provides a summary of the amount of retinol after aging for Compositions Al and Bl, which had pHs of 6.3 and 6, respectively.Table 3

[0122] It can be seen from Tables 2 and 3, that the addition of salicylic acid and sodium ascorbyl phosphate decreases the retinol stability of Compositions Bl and B2 relative to Compositions Al and A2. Notably, however, the addition of salicylic acid and sodium ascorbyl phosphate reduced the retinol stability for Composition Bl less than for Composition B2. It can be seen from Tables 2 and 3 that the stability of retinol in the presence of salicylic acid and sodium ascorbyl phosphate was unexpectedly increased by adding sodium hydroxide to achieve a pH of about 6 or more. Example 3

[0123] Three non-limiting example skin care compositions (Example Compositions A-C) were prepared in accordance with aspects of the disclosure. A comparative skin care composition (Comparative Composition 1) and a placebo composition (Placebo Composition) were alsoDocket No. 863910-00-WQ-01-SH prepared. The formulations of the Placebo Composition, Comparative Composition 1 , andExample Compositions A-C arc provided in Table 4.Table 4Docket No. 863910-00-WO-01-SHExample 4

[0124] Example Compositions A-C and Comparative Composition 1 from Example 3 were evaluated to assess their respective retinol stabilities. Specifically, samples of Example Compositions A-C and Comparative Composition 1 were stored at room temperature (e.g., about 21°C) and assayed for retinol content at the beginning of the evaluation, after 30 days, after 60 days, and after 90 days of aging.

[0125] Assays were conducted by weighing about 20 mg of the respective sample and then adding 10 mL of methanol. The samples were then thoroughly sonicated and vortexed to ensure all retinol in the formula was dissolved in the methanol. Retinol levels were assayed on an Agilent™ 1100 Series HPLC with a UV-Vis detector. A reverse-phase, Agilent™ C18 “Zorbax” column was used (150 mm X 4.6 mm) with an attached guard column. The mobile phase consisted of 99 / 1 methanol / water, which was run at a flow rate of 1.0 mL / min. 20 uL of solution was injected. Retinol could be detected at 325 nm with a retention time of approximately 2.7 minutes.

[0126] A summary of the retinol stability for Example Compositions A-C and Comparative Composition 1 are shown in FIG. 1. Notably, Example Compositions A-C achieved a significantly better retinol stability than Comparative Composition 1.Example 5

[0127] The Placebo Composition, Example Compositions A and B, and Comparative Composition 1 from Example 3 were evaluated to determine their respective bioefficacies. Specifically, samples of the Placebo Composition, Example Composition A, Example Composition B, and Comparative Composition 1 were stored at room temperature (e.g., about 21°C) for 90 days. The samples were diluted in keratinocyte culture media and then added to proliferating normal human epidermal keratinocytes (NHEK) cells. The cells were subsequently incubated at a temperature of 37 °C and in an atmosphere containing 5 vol.% of CO2 for 24 hours.

[0128] After the 24 hours of incubation, the cells were collected, the RNA isolated, and the expression of actively transcribed genes was analyzed with qPCR. The results were quantified and graphed (see FIGS. 2-4) as fold expression relative to the untreated control, which was set to 1. Fold expression values of greater than 1 indicate upregulation I stimulation of gene expression, while values of less than 1 indicate downregulation / inhibition of expression. Specifically, FIG. 2 is a graph of the KRT15 expression in the NHEK cells, FIG. 3 is a graph of the HBEGF expression in the NHEK cells, and FIG. 4 is a graph of the MMP1 expression in the NHEK cells. As seen inDocket No. 863910-00-WO-01-SHFIGS. 2-4, Example Compositions A and B desirably upregulated the expression of EGF-like growth factor (HBEGF) and keratin 15 (KRT15), while downrcgulatcd the expression of matrix metalloproteinase 1 (MMP1).

Claims

Docket No. 863910-00-WO-01-SHCLAIMSWhat is Claimed is:

1. A skin care composition comprising: a retinoid; salicylic acid and / or a salt thereof; from about 1.5 to about 17 wt.% of a silicone; from about 1 to about 8 wt.% of a vitamin B; from about 5 to about 40 wt.% of a fatty component; and water, wherein the skin care composition has a pH of about 4.75 to about 6.7 and all weight percentages are based on the total weight of the skin care composition.

2. The skin care composition according to claim 1, wherein the pH is about 5 to about 6.3.

3. The skin care composition according to claim 1 or claim 2, wherein the retinoid is selected from the group consisting of retinol, retinal, tretinoin, acitretin, etretinate, adapalene, arotinoid, tazarotene, retinoic acid, hydroxypinacolone retinoate, and a combination of two or more thereof.

4. The skin care composition according to any foregoing claim, wherein the retinoid comprises retinol.

5. The skin care composition according to any foregoing claim, wherein the retinoid is present in an amount from about 0.1 to about 3 wt.%.

6. The skin care composition according to any foregoing claim, wherein the salicylic acid and / or a salt thereof is present in an amount from about 1 to about 5 wt.%.

7. The skin care composition according to any foregoing claim, wherein the silicone comprises dimethicone, poly silicone- 11, or a combination thereof.Docket No. 863910-00-WO-01-SH8. The skin care composition according to any foregoing claim, wherein the vitamin B is selected from the group consisting of vitamin B3 or derivatives thereof.

9. The skin care composition according to any foregoing claim, wherein the vitamin B comprises niacinamide, nicotinic acid, nicotinyl alcohol, a salt thereof, or a combination thereof.

10. The skin care composition according to any foregoing claim, wherein the fatty component comprises a fatty ester, fatty alcohol, a fatty ether, a non-silicone oil, or a combination of two or more thereof.

11. The skin care composition according to claim 10, wherein the fatty component comprises a non-silicone oil selected from isododecane, isodecane, decane, dodecane, C11-13 isoalkane, and a combination of two or more thereof.

12. The skin care composition according to claim 10 or claim 11, wherein the fatty component comprises a fatty ester selected from isoamyl laurate, ethyl linoleate, ethylhexyl stearate, coco-caprylate / caprate, isoamyl cocoate, glyceryl stearate, PEG- 100 stearate, poly glyceryl- 10 dipalmitate, poly glyceryl- 10 dioleate, and a combination of two or more thereof.

13. The skin care composition according to any one of claims 10 to 12, wherein the fatty component comprises a fatty alcohol, the fatty alcohol comprising cetyl alcohol, stearyl alcohol, cetearyl alcohol, lauric alcohol, or a mixture of two or more thereof.

14. The skin care composition according to any foregoing claim, wherein the water is present in an amount from about 20 to about 60 wt.%.

15. The skin care composition according to any foregoing claim further comprising: a polyol in an amount from about 0.5 to about 20 wt.%.

16. The skin care composition according to claim 15, wherein the polyol comprises glycerin, propylene glycol, capryl glycol, ethylene glycol, propylene glycol, butylene glycol, pentyleneDocket No. 863910-00-WO-01-SH glycol, hexylene glycol, diglycerin, diethylene glycol, dipropylene glycol, or a combination thereof.

17. The skin care composition according to any foregoing claim further comprising: a skin conditioning agent comprising syringa vulgaris leaf cell culture extract, dipotassium glycyrrhizinate, bakuchiol, hydrogenated olive oil unsaponifiables, hydrogenated ethylhexyl olivate, or a combination of two or more thereof.

18. The skin care composition according to any foregoing claim further comprising: one or more peptide comprising tripeptide-29, acetyl tetrapeptide-2, trifluoroacetyl tripeptide-2, myristoyl nonapeptide- 3, or a combination thereof.

19. The skin care composition according to claim 18, wherein the one or more peptide consists of myristoyl nonapeptide-3 and at least one of tripeptide-29, acetyl tetrapeptide-2, or trifluoroacetyl tripeptide-2.

20. The skin care composition according to any foregoing claim, wherein the skin care composition is substantially free of or free of anionic surfactants, amphoteric surfactants, and cationic surfactants.

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