Enhanced activity of active ingredients by sulfur

Abstract

The invention relates to a composition comprising sulfur and a 2nd active ingredient (ai), in a ratio of 1000:1 – 1:100 (w / w; sulfur: 2nd ai). The invention further relates to a method for protecting a plant or plant part against a pest and / or for treating a plant and / or plant part and / or soil that is affected by a pest, comprising providing sulfur and 2nd ai. The invention further provides a use of sulfur for enhancing the activity of a 2nd ai against nematodes, fungi and / or oomycetes. The invention further provides a use of sulfur and 2nd ai.

Description

[0001]P137412PC00 Title: Enhanced activity of active ingredients by sulfur Field: The invention relates to compositions to control diseases on plants and plant parts and to methods to improve development and yield of plants. BACKGROUND Several types of elemental sulfur (S0) exist that are used in crop protection products, both as fungicide and as insecticide. Examples of different types of sulfur that are used as active ingredient in crop protection products include S0 from sulfur mines; S0obtained via chemical processes (the ”Claus process”) from hydrogen sulfide (H2S) present in gas and H2S released during oil refinery; and S0obtained from H2S via oxidation by sulfur bacteria in a bio-reactor, so called “microbial sulfur” such as in the product Cerasulfur® of Ceradis® (Wageningen, the Netherlands). S0 can be present in many different molecular forms like aliphatic structure with different number of sulfur atoms linked to each other, and (ortho)rhombic sulfur, which also may have a different number of atoms in a rhombic molecular structure. Most prevalent in nature is cyclo-octasulfur (cyclo-S8). In crop protection, sulfur is used for the control of different plant pests. Plant pests include pathogenic true-fungi species belonging to the basidiomycetes and ascomycetes divisions. True-fungi species that can be effectively targeted by sulfur include powdery mildew (Oidium spp.), septoria (Mycosphaerella graminicola), apple scab (Venturia inaequalis). In crop protection, sulfur is also used for the control of mites, for example citrus rust mite, brown citrus rust mite, bud mite, vine mite, grape leaf blister mite, two-spotted mite, tomato russet mite, bean spider mite, and insects such as white louse scale. Crops on which sulfur is used as insecticide and / or fungicide include, ornamentals, fruits, vegetables and cereals such as, for example, pome and stone fruit, citrus, grapevines, kiwifruit, strawberries, tomatoes and wheat. Several diseases affecting industrially important crops are caused by other fungus-like species that belong to the division of oomycetes, including for instance Pythium species on corn, Phytophthora species such as Phytophthora infestans on potato, Plasmopara species such as Plasmopara viticola on grape, Bremia species such as Bremia lactucae on lettuce. Characteristics that separate oomycetes from true-fungi include but are not limited to, difference in cell wall composition (oomycetes are composed of cellulose instead of chitin), level of ploidy (oomycetes have a diploid nucleus), and infecting structures (most species of oomycetes produce an infecting structure called a zoospore, which is mobile). Broad spectrum fungicides that can control true-fungi are not per se effective in controlling oomycetes. This is the case of for instance for natamycin that has been reported to interact with the plasma membrane, especially with sterols. Natamycin has been reported to interact with ergosterol, the main sterol in membranes in the fungal classes ascomycetes and basidiomycetes and in yeasts and amoeba (Welscher et al., 2008. J Biol Chem 283: 6393–6401). Since ergosterol is absent in the oomycetes, natamycin is inefficient at controlling the diseases caused by the oomycetes species. It is also common knowledge that sulfur does not or little control the oomycetes species (Williams and Cooper, 2004. Plant Pathol 53: 263-279). In addition to oomycetes, commonly accepted plant pests that are not efficiently controlled by sulfur are Fusarium species, Botrytis cinerea, Sclerotinia sclerotiorum, Rhizoctonia species, Colletotrichum species, Puccinia species, nematode species and several types of insects like thrips and aphids. In crop protection, either a single fungicide and / or insecticide and / or nematicide, or a combination of different fungicides and / or insecticides and / or nematicide can be applied on a crop for controlling certain fungicidal / insecticidal diseases. A combination of different fungicides and / or different insecticides has several advantages: it reduces the chance on resistance development for a particular fungicide and / or insecticide and / or nematicide; the spectrum of pathogenic fungi and insects to which a combination of fungicides and / or insecticides is effective is broader than that of a single fungicide and / or insecticide and / or nematicide; combination applications may reduce time required for application by a farmer. There is thus a need for novel combinations of fungicides and / or nematicide that can be applied to a crop or soil with broad effectiveness against different pests. BRIEF DESCRIPTION OF THE INVENTION It was surprisingly found that sulfur caused an increased biologic activity of a 2ndactive ingredient. The observed synergy between sulfur and 2ndactive ingredient is clear from the examples shown herein below. Accordingly, the invention provides a composition comprising sulfur and a 2ndactive ingredient (ai), in a ratio of 1000:1 – 1:100 (w / w; sulfur: 2ndai), preferably 750:1 - 1:50 (w / w; sulfur: 2ndai) and, optionally, one or more surfactants, wherein the 2ndai is a pesticide selected from clove oil, zoxamide, pydiflumetofen, metalaxyl-M, folpet, propamocarb, fluopyram, mandipropamid, fluopicolide, dithianon, dicloran, benthiavalicarb isopropyl, bixafen, thifluzamide, isopyrazam, adepidyn, mefentrifluconazole, metconazole, copper oxychloride, an enzyme such as beta-glucanase preferably beta-1,3(4)-glucanase, pyrimethanil, boscalid, abamectin, dodine, chitosan, copper sulfate, chitosan hydrochloride, COS-OGA, onion extract, nettle extract, mustard extract, horsetail extract, silicic acid, willow extract, swinglea glutinosa extract, fructose, sucrose, sodium hydrogen carbonate, calcium hydroxide, magnesium hydroxide, sunflower oil, maize oil, soyabean oil, onion oil, lecithin, neem oil, activated charcoal, bentonite, thymol, carvacrol, eugenol, geraniol, limonene, acetic acid, natamycin, potassium hydrogen bicarbonate, paraffinic oil, aluminium sulfate, fatty acid, garlic extract, a phosphonate or a salt thereof, laminarine and a microorganism, including an extract of a microorganism, selected from a Trichoderma species, a yeast-based substance, a Bacillus species such as B. amyloliquefaciens, a Rhizobium species and any combination thereof. In embodiments, the 2nd ai is selected from clove oil, zoxamide,pydiflumetofen, metalaxyl-M, propamocarb, fluopyram, mefentrifluconazole, dicloran, copper oxychloride, Swinglea glutinosa extract, beta-1,3(4)-glucanase, chitosan, pyrimethanil, boscalid, abamectin, chitosan, copper sulfate, horsetail extract, sodium hydrogen carbonate, sunflower oil, maize oil, soyabean oil, lecithin, neem oil, thymol, carvacrol, geraniol, limonene, acetic acid, natamycin, potassium hydrogen bicarbonate, paraffinic oil, garlic extract, a yeast-based substance, a Bacillus species such as B. amyloliquefaciens, and any combination thereof. In embodiments, the 2nd ai is selected from Bacillus thuringiensis, B.amyloliquefaciens, B. thuringiensis, B. subtilis, B. pulilus and any combination thereof, preferably 2ndai is B. amyloliquefaciens. In embodiments, the composition further comprises at least one antifoamingagent, at least one thickening agent and / or rheology agent, at least one stabilizing agent, glycerol, or any combination thereof. The invention further relates to a method for protecting a plant and / or plant part and / or a soil against a pest and / or for treating a plant and / or plant part and / or soil that is affected by a pest, comprising the steps of: (a) providing sulfur and a 2ndactive ingredient (ai), in a ratio of 1000:1 – 1:100 (w / w; sulfur: 2ndai), preferably 750:1 - 1:50 (w / w; sulfur: 2ndai); (b) applying the sulfur and 2ndai to said plant and / or plant part and / or soil, wherein the 2ndai is selected from clove oil, zoxamide, pydiflumetofen, metalaxyl-M, folpet, propamocarb, fluopyram, mandipropamid, fluopicolide, dithianon, dicloran, benthiavalicarb isopropyl, bixafen, thifluzamide, isopyrazam, adepidyn, mefentrifluconazole, metconazole, copper oxychloride, an enzyme such as beta-glucanase preferably beta-1,3(4)-glucanase, pyrimethanil, boscalid, abamectin, dodine, chitosan, copper sulfate, chitosan hydrochloride, COS- OGA, onion extract, nettle extract, mustard extract, horsetail extract, silicic acid, willow extract, swinglea glutinosa extract, fructose, sucrose, sodium hydrogen carbonate, calcium hydroxide, magnesium hydroxide, sunflower oil, maize oil, soyabean oil, onion oil, lecithin, neem oil, activated charcoal, bentonite, thymol, carvacrol, eugenol, geraniol, limonene, acetic acid, natamycin, potassium hydrogen bicarbonate, paraffinic oil, aluminium sulfate, fatty acid, garlic extract, a phosphonate or a salt thereof, laminarine and a microorganism, including an extract of a microorganism, selected from a Trichoderma species, a yeast-based substance, a Bacillus species such as B. amyloliquefaciens, a Rhizobium species and any combination thereof, wherein the pest is a nematode and / or a fungus, including an ascomycete and a basidiomycete, and / or a oomycete. In embodiments, said sulfur and 2ndai are provided by a composition of the invention. In embodiments, the plant part is a seed, bulb, root, leaf, flower, fruit orvegetable. In embodiments, the said sulfur and 2nd active ingredient (ai) are providedsequentially to the plant, plant part, or soil, whereby the sulfur or 2ndai is applied first to a plant, plant part, or soil, followed by the remaining of the sulfur or 2ndai, preferably said remaining of the sulfur or 2ndai may be applied after 2 days, 4 days, 6 days, 7 days, 8 days, 10 days, 12 days, 14 days, 16 days, 18 days and / or 20 days after applying the first sulfur or 2ndai. In embodiments, the pest is an oomycete.In embodiments, the pest is a nematode and / or a fungus.In embodiments, the 2nd ai is selected from clove oil, zoxamide,pydiflumetofen, metalaxyl-M, propamocarb, fluopyram, mefentrifluconazole, dicloran, copper oxychloride, Swinglea glutinosa extract, beta-1,3(4)-glucanase, chitosan, pyrimethanil, boscalid, abamectin, chitosan, copper sulfate, horsetail extract, sodium hydrogen carbonate, sunflower oil, maize oil, soyabean oil, lecithin, neem oil, thymol, carvacrol, geraniol, limonene, acetic acid, natamycin, potassium hydrogen bicarbonate, paraffinic oil, garlic extract, a yeast-based substance, a Bacillus species such as B. amyloliquefaciens, and any combination thereof. The invention further relates to a use of sulfur for enhancing the activity of a 2ndai against a nematode and / or a fungus, including an ascomycete and basidiomycete and / or an oomycete, wherein 2ndai is selected from clove oil, zoxamide, pydiflumetofen, metalaxyl-M, folpet, propamocarb, fluopyram, mandipropamid, fluopicolide, dithianon, dicloran, benthiavalicarb isopropyl, bixafen, thifluzamide, isopyrazam, adepidyn, mefentrifluconazole, metconazole, copper oxychloride, an enzyme such as beta-glucanase preferably beta-1,3(4)- glucanase, pyrimethanil, boscalid, abamectin, dodine, chitosan, copper sulfate, chitosan hydrochloride, COS-OGA, onion extract, nettle extract, mustard extract, horsetail extract, silicic acid, willow extract, swinglea glutinosa extract, fructose, sucrose, sodium hydrogen carbonate, calcium hydroxide, magnesium hydroxide, sunflower oil, maize oil, soyabean oil, onion oil, lecithin, neem oil, activated charcoal, bentonite, thymol, carvacrol, eugenol, geraniol, limonene, acetic acid, natamycin, potassium hydrogen bicarbonate, paraffinic oil, aluminium sulfate, fatty acid, garlic extract, a phosphonate or a salt thereof, laminarine and a microorganism, including an extract of a microorganism, selected from a Trichoderma species, a yeast-based substance, a Bacillus species such as B. amyloliquefaciens, a Rhizobium species and any combination thereof. The invention further relates to a use of sulfur and a 2ndai for protecting a plant and / or plant part and / or soil against a pest and / or treating a plant and / or plant part and / or soil affected by a pest, wherein the pest is a nematode and / or a fungus, including an ascomycete and basidiomycete, and / or an oomycete wherein 2ndai is selected from clove oil, zoxamide, pydiflumetofen, metalaxyl-M, folpet, propamocarb, fluopyram, mandipropamid, fluopicolide, dithianon, dicloran, benthiavalicarb isopropyl, bixafen, thifluzamide, isopyrazam, adepidyn, mefentrifluconazole, metconazole, copper oxychloride, an enzyme such as beta- glucanase preferably beta-1,3(4)-glucanase, pyrimethanil, boscalid, abamectin, dodine, chitosan, copper sulfate, chitosan hydrochloride, COS-OGA, onion extract, nettle extract, mustard extract, horsetail extract, silicic acid, willow extract, swinglea glutinosa extract, fructose, sucrose, sodium hydrogen carbonate, calcium hydroxide, magnesium hydroxide, sunflower oil, maize oil, soyabean oil, onion oil, lecithin, neem oil, activated charcoal, bentonite, thymol, carvacrol, eugenol, geraniol, limonene, acetic acid, natamycin, potassium hydrogen bicarbonate, paraffinic oil, aluminium sulfate, fatty acid, garlic extract, a phosphonate or a salt thereof, laminarine and a microorganism, including an extract of a microorganism, selected from a Trichoderma species, a yeast-based substance, a Bacillus species such as B. amyloliquefaciens, a Rhizobium species and any combination thereof. DETAILED DESCRIPTION OF THE INVENTION Definitions The term “sulfur”, as is used herein, includes reference to elemental sulfur (S0). The term elemental sulfur (S0) includes allotropes of sulfur such as biosulfur, plastic (amorphous) sulfur, monoclinic sulfur, rhombic sulfur composed of S8 molecules, and other ring molecules such as S7 and S12 but also aliphatic forms of sulfur such as S2, S4, S6, S8 andS10. The term sulfur also includes the product of a chemical process, termed Claus process, which includes an oxidation step of hydrogen sulfide (H2S) to sulfur dioxide (SO2) and a catalyzed reaction of H2S with SO2 to form elemental sulfur (S0) (Schreiner, 2008. Chemie Unserer Zeit 42: 378). The term “biosulfur”, as is used herein, refers to microbially produced sulfur. Said biosulfur has some unique properties, as compared to chemically produced sulfur such as, for example, by the Claus-process. Most important, biosulfur is more hydrophilic than chemically produced sulfur. Biosulfur may be produced by bacteria in a process termed THIOPAQ™, as described in US patent 6,656,249. The term “surfactant”, as is used herein, refers to an ionic (anionic or cationic) or non-ionic surface-active agent. A surfactant can have multiple functions, one skilled in the art can decide when to use what surfactant. For example, a surfactant can be used as emulsifier, spreading agent, dispersant / wetting agent, solubilizer, penetration enhancer, protective colloid, anti- foam agents, stabilizer, thickening agent and / or rheology modifier, and a sticking agent. For the present invention, said surfactant may be an emulsifier, spreading agent and / or a dispersant / wetting agent. The terms “plant” and “crop”, as are used herein, both refer to a cultivated plant, tree or fungus that is cultivated for food, clothing, livestock fodder, biofuel, medicine, or other use. The term “active ingredient”, as is used herein, refers to a chemical or micro- organism, including a virus, that enables a pesticide to perform its function. A function of a pesticide can be a fungicide, insecticide, nematicide, acaricide, or a combination thereof. As is indicated herein below, it is taught that sulfur is causing an increased biological activity of a second active ingredient. The term “powdery mildew”, as is used herein, refers to a disease that affects a wide range of plants and which is caused by fungi of the family Erysiphaceae within the order of Erysiphales of ascomycete fungi. The term “pest”, including “plant pest”, as used herein, refers to any organism having a negative impact on a plant or plant part. A plant pest can be a virus, a bacterium, a fungus, an oomycete, a protist, an insect, a mite, a tick, a nematode, a weed or a larger animal. In embodiments, the pest is one or more of an insect, a nematode, a fungus such as an ascomycete and basidiomycete and / or an oomycete. As used herein, the term fungus is used to refer to true fungus species, not including an oomycete, which is a fungal-like organism but not a true fungus. The term “off target”, as is used herein, refers to a pest against which sulfur as single agent is not or only limitedly active. In a direct effect assay (i.e., an experimental test used to measure the direct impact of sulfur on a pest in field conditions or lab conditions such as in a plate assay or detached leaf assay for insects), the efficacy of sulfur against an off target pest is less than 40%, preferably less than 30%, more preferably less than 20%, even more preferably less than 10%, most preferably 0%. The terms “increased biological activity” and “increasing biological activity”, as used herein, refer to an improvement of the curative, preventive and / or persistence performance of an active ingredient in the presence of sulfur, when compared to the same active ingredient without sulfur. The term also includes an expansion of the range of target organisms for the active ingredient, for example by including one or more basidiomycetes species, oomycetes species, insects such as nematodes, thrips or aphids, or a combination thereof, against which the active ingredient did not have activity before the increase of activity. Without being bound by theory, it is taught that sulfur is causing the increased biological activity of a second active ingredient (2ndai). More specifically, without being bound by theory, it is anticipated that sulfur and its reactive intermediates such as hydrogen sulfide, sulfite, and thiosulfate can directly and / or indirectly modify and / or inactivate enzymes and other proteins, for example proteins that regulate critical physiological functions, in a pest cell such as fungal, oomycete and / or nematode cell. It is hypothesized that the action of sulfur and / or sulfur-derived reactive intermediates on enzymes and proteins can synergistically be enhanced by the combination with a 2ndactive ingredient that is able to alter or inhibit enzymatic and protein activity in such a pest cell. Said a 2ndactive ingredient that is able to alter or inhibit enzymatic and protein activity can be a pesticide or plant defense–inducing compound. Examples of a 2ndactive ingredient that is able to alter or inhibit enzymatic and protein activity is a fungicidal pesticide such as one of those listed in the FRAC Code List with target codes A, B, C, D, F, H, I, G, M, P, U, NC, BM01 and BM02 as well as compounds with unknown or multiple sites of action (see further herein below). A 2ndactive ingredient that is able to alter or inhibit enzymatic and protein activity can exert its effects in pests via interfering, either directly or indirectly, with the enzymes and / or proteins in a pest cell, or both. Examples of a 2ndactive ingredient that is able to alter or inhibit enzymatic and protein activity directly are pyrimenthanil, folpet, copper compounds like copper hydroxide, copper oxychloride and copper sulfate, boscalid, pydiflumetofen, abamectin, chitosan, fluopyram, acetic acid, terpenes like eugenol in clove oil, geraniol, carvacrol, thymol and limonene, sodium bicarbonate, Bacillus species such as B. amyloliquefaciens and B. thuringiensis, garlic extract, metalaxyl-M,neem oil, potassium hydrogen bicarbonate, propamocarb, Trichoderma species suchas T. harzianum, mefentrifluconazole, zoxamide, dicloran and swinglea glutinosa extract. Examples of a 2ndactive ingredient that is able to alter or inhibit enzymatic and protein activity indirectly are yeast-based substance such as Cerevisane, natamycin, acetic acid, sodium bicarbonate, beta-glucanase such as beta-1,3(4)- glucanase, Bacillus species such as B. amyloliquefaciens, garlic extract, neem oil, paraffinic oil, potassium hydrogen bicarbonate, Rhizobium species such as R.leguminosarum, Trichoderma species such as T. harzianum, plant oils likesoyabean oil, maize oil and sunflower oil and lecithin. Said increased biological activity of a 2ndai may be against an organism against which sulfur itself, and the 2nd ai in the absence of sulfur, have no, or hardly any, activity. For example, the activity of pyrimethanil against the oomycete Pythium ultimum is significantly increased in the presence of sulfur, although sulfur itself is hardly active against this oomycete. For example, the activity of a combination of boscalid and sulfur against the oomycete Pythium ultimum is significant (and synergistic), although boscalid itself is not active against this oomycete, and sulfur itself is hardly active against this oomycete. The term "plant part", as used herein, refers to single cells, cell clumps and plant tissues, including tissue cultures. Examples of plant parts include, but are not limited to, pollen, ovules, leaves, stems, embryos, roots, root tips, anthers, flowers, fruits, shoots, scions, rootstocks, seeds, protoplasts, calli, and the like, preferably seeds, roots and / or leaves. The term “soil”, as is used herein, refers to a mixture of organic matter, minerals, gases, liquids, and organisms that support the life of plants and soil organisms. The term includes reference to a growth substrate in which seeds can be planted or germinated, and / or in which plants or mushrooms can grow and develop, such as vermiculite, cocopeat, rockwool and hydroponic systems. The term “chemical compound”, as used herein, refers to a natural or synthetic compound. A synthetic compound may be formed under human control by any chemical reaction, by chemical synthesis or by biosynthesis. A natural compound is a compound that may be produced by a living organism and can be found in nature, such as a plant derived compound. The term “pesticide”, as used herein, refers to a compound that can inhibit, suppress, paralyze, repel or kill a pest. In embodiments, the pesticide is a fungicide, a nematicide or any combination thereof. It is noted that in the art, no specific term exists for pesticides that are active against oomycetes. Such pesticides are commonly classified under the general term “fungicides”, even though oomycetes are no true fungi. As used herein, the term “fungicide” includes a pesticide that is active against oomycetes. The term “pesticidal activity” or “pesticidal effect”, as used herein, refers to the effect of a pesticide in terms of inhibiting, suppressing, impairing, paralyzing, repelling, or killing a pest. The pesticidal activity of a compound can be measured using multiple indicators such as the mortality (i.e., the number of dead pests), reduced pest mobility, inhibition of pest growth, decreased reproduction (e.g., reduced egg laying or hatching rate), feeding suppression, molting inhibition, and / or behavioral changes such as avoidance or disorientation. The pesticidal activity of a pesticide can be measured as shown in the examples. For example, the pesticidal activity of a compound may be measured by exposing one or more pests to said compound and assessing the mobility of the one or more exposed pests. The measured mobility of the one or more pests exposed to the compound can be compared to the mobility of one or more pests that were exposed to a non-pesticidal compound, such as an inactivated compound or water. If the mobility of the one or more pests exposed to the tested compound is lower than the mobility of the pests exposed to the non-pesticidal compound, then the tested compound may be considered pesticidal. In a similar way, a pesticidal activity of a compound may be measured by exposing one or more pests to said compound and measuring if the one or more exposed pests are dead. The percentage of dead pests that were exposed to the compound can be compared to the percentage of dead pests exposed to a non-pesticidal compound, such as an inactivated compound or water. If the percentage of dead pests exposed to the tested compound is higher than the percentage of dead pests exposed to the non-pesticidal compound, then the tested compound may be considered pesticidal. In a similar way, a pesticidal activity of a compound may be measured by exposing one or more pests to said compound and measuring the growth inhibition of said one or more pests. The amount of growth inhibition measured in the one or more pests that were exposed to the compound can be compared to the amount of growth inhibition measured in one or more pests exposed to a non-pesticidal compound, such as an inactivated compound or water. If the amount of growth inhibition measured in the one or more pests exposed to the tested compound is higher than the amount of growth inhibition measured in the pests exposed to the non-pesticidal compound, then the tested compound may be considered pesticidal. To measure the mobility or death of a pest, several methods are known in the art, for example microscopy, staining, biochemical tests such as an ATP- or enzyme-based assay. For a nematode, a so-called destructive method may be used, wherein immobilized nematodes are cut to determine intestinal bursting, which is an indication of nematode death. For a fungus or oomycete, growth inhibition may be measured for example by using a caliper. In addition for a fungus or oomycete, growth inhibition can be measured by assessing reduction in disease symptoms caused by the said fungus or oomycete. The term “fungicide”, as is used herein, refers to a compound or composition that can inhibit, suppress, paralyze, repel or kill fungi, preferably including their spores. Fungicides are generally active against Ascomycetes, such as apple scab (Venturia inaequalis), rice blast (Magnaporthe grisea), black knot (Dibotryon morbosum), false smut (Ustilaginoidea virens), and gray mold (Botrytis cinerea). In general, fungicides are less, or not, effective against Basidiomycetes such as kernel smut (Tilletia horrida), brown-rot (Fomitopsis species), and white-rot (Panellus species). A fungicide can be effective against Basidiomycetes such as kernel smut (Tilletia horrida), brown-rot (Fomitopsis species), and white-rot (Panellus species). A fungicide can be effective against oomycetes such as damping off and root rot(Pythium ultimum), downy mildew and Phythophthora species such as the causingagent for potato late blight (Phytophthora infestans). Some fungicides, such as for example natamycin, are not or poorly active against oomycetes, which are not true fungi, although sharing similar methods of infecting plants. In addition, sulfur is not or poorly active against off targets (see definition herein above) like oomycetes, downy mildew, Fusarium species, Puccinae species, Sclerotinia species, Rizoctonia species, Colletotrichum species and Botrytis cinerea. Most fungicides, including sulfur, are not or poorly active against nematodes, aphids, and thrips. Active ingredients of a fungicide includes reference to pyrimethanil, boscalid, pydiflumetofen, metalaxyl-M, folpet, propamocarb, mandipropamid, fluopicolide, dithianon, dicloran, fluopyram, zoxamide, benthiavalicarb isopropyl, dodine, fluopyram, bixafen, thifluzamide, isopyrazam, an N-methoxy-(phenethyl)-pyrazole- carboxamide such as adepidyn, mefentrifluconazole, metconazole, chitosan, chitosan hydrochloride, COS-OGA, onion extract, nettle extract, mustard extract, horsetail extract (Equisitum arvense), silicic acid, willow extract, swinglea glutinosa extract, fructose, sucrose, clove oil, sodium hydrogen carbonate, calcium hydroxide, magnesium hydroxide, sunflower oil, maize oil, soyabean oil, onion oil, lecithin, neem oil (comprising the active ingredient azadirachtin), activated charcoal, bentonite, thymol, carvacrol, eugenol, geraniol, limonene, acetic acid, copper sulfate, copper oxychloride, natamycin, potassium hydrogen bicarbonate, paraffinic oil, aluminium sulfate, garlic extract (comprising allicin), a phosphonate, a fatty acid or a salt thereof, laminarine, B. subtilis, B. pulilus, an enzyme such as beta-glucanase, a Rhizobium species such as R. leguminosarum. FRAC stands for Fungicide Resistance Action Committee, which provides a classification of fungicides into groups based on their mode of action. Used herein is FRAC poster version 2024, which can be downloaded from the FRAC website (available at frac.info / knowledge-database / downloads). The term “nematicide”, as is used herein, as used herein, refers to a compound or composition that can kill, impair, paralyze, or repel nematodes, including nematode eggs, nematode juvenile, and nematode adults. The term “nematicide” as used herein refers to the effects on pathogenic nematodes. The Nematicide Mode of Action Classification Scheme, identified by N-codes, is a classification of nematicides into groups based on their mode of action, provided by the IRAC. Used herein is Nematicide Mode of Action Classification Scheme Version 2.1, which can be downloaded from the IRAC website (available at irac-online.org / ). Examples of nematicides, as used herein, include reference to Trichoderma asperellum, T. harzianum, and T. atroviride, and abamectin. The term “effective amount of an active ingredient”, as used herein, refers to the amount of an active ingredient, such as a sulfur and a 2ndai, that exhibits a pesticidal activity. Compositions of the invention The invention provides a composition comprising sulfur and a 2ndactive ingredient (2ndai) as well as methods wherein sulfur and a 2ndai are applied. Furthermore, the invention provides used of sulfur and a 2ndai. The invention relates to a composition comprising sulfur and a 2ndactive ingredient (ai), in a ratio of 1000:1 – 1:100 (w / w; sulfur: 2ndai), such as 750:1 - 1:75; 700:1 - 1:50; n 600:1 - 1:30; 500:1 - 1:20; 200:1 - 1:10; 100:1 - 1:5, including about 1:1 (w / w; sulfur: 2ndai). In embodiments, the amount of sulfur in said composition is higher than the amount of 2ndai. In embodiments, the ratio of sulfur over 2ndai is 1000:1 - 1:1 (w / w; sulfur: 2nd ai), such as 750:1 - 1:1; 700:1 - 1:1; 600:1 - 2:1; 500:1 - 3:1; 200:1 - 5:1; including 100:1 - 10:1 (w / w; sulfur: 2ndai). In embodiments, the amount of sulfur in said composition is lower than the amount of 2nd ai. In embodiments, the ratio of sulfur over 2ndai is 1:1 - 1:100 (w / w; sulfur: 2ndai), such as 1:1 - 1:75, 1:1 - 1:50, 1:1 - 1:20, 1:1 - 1:10, 1:1 - 1:5, 1:1 - 1:3, 1:1 - 1:2, 1:1 - 1:1.5 (w / w; sulfur: 2ndai). In embodiments, in a composition or method of the invention, the ratio sulfur and pyrimethanil as a 2ndactive ingredient (ai) is 500:1 - 1:50, preferably 400:1 - 1:10, preferably 300:1 - 1:5, preferably 200:1 - 1:2, preferably 100:1 - 1:1, preferably 50:1 - 2:1, preferably 25:1 - 5:1, such as 5:1, 10:1 and / or 25:1 (w / w; sulfur: 2ndai). In embodiments, in a composition or method of the invention, the ratio sulfur and yeast-based substance as a 2ndactive ingredient (ai) is 500:1 - 1:50, preferably 400:1 - 1:20, preferably 300:1 - 1:10, preferably 200:1 - 1:5, preferably 150:1 - 1:2, preferably 75:1 – 1:1, such as 75:1, 200:33, 2:1 and / or 1:1 (w / w; sulfur: 2ndai). In embodiments, in a composition or method of the invention, the ratio sulfur and boscalid as a 2ndactive ingredient (ai) is 500:1 - 1:200, preferably 400:1 - 1:100, preferably 300:1 - 1:50, preferably 200:1 - 1:20, preferably 100:1 - 1:10, preferably, preferably 50:1-1:5, preferably 10:1 - 1:2, preferably 5:1 – 1:1, such as 5:1 and / or 1:1 (w / w; sulfur: 2ndai). In embodiments, in a composition or method of the invention, the ratio sulfur and abamectin as a 2ndactive ingredient (ai) is 500:1 - 1:2, preferably 400:1 - 1:1, preferably 300:1 - 2:1, preferably 200:1 - 5:1, preferably 100:1 – 10:1, such as 100:1 and / or 10:1 (w / w; sulfur: 2ndai). In embodiments, in a composition or method of the invention, the ratio sulfur and chitosan as a 2ndactive ingredient (ai) is 500:1 - 1:2, preferably 400:1 - 1:1, preferably 300:1 – 2:1, preferably 200:1 – 3:1, preferably 100:1 – 3.2:1, such as 100:1 , 10:1, 160:19, 6.4:1 and / or 3.2:1 (w / w; sulfur: 2ndai). In embodiments, in a composition or method of the invention, the ratio sulfur and pydiflymetofen as a 2ndactive ingredient (ai) is 500:1 - 1:2, preferably 400:1 - 1:1, preferably 300:1 – 2:1, preferably 200:1 - 5:1, preferably 100:1 - 10:1, such as 100:1 and / or 10:1 (w / w; sulfur: 2ndai). In embodiments, in a composition or method of the invention, the ratio sulfur and clove oil as a 2ndactive ingredient (ai) is 2000:1 - 1:5, preferably 1000:1 - 1:2, preferably 500:1 - 1:1, such as 1:1, 5:1, 10:1, 100:1 and / or 500:1 (w / w; sulfur: 2ndai). In embodiments, in a composition or method of the invention, the ratio sulfur and metalaxyl-M as a 2ndactive ingredient (ai) is 500:1 - 1:2, preferably 400:1 - 1:2, preferably 300:1 - 1:2, preferably 200:1 - 1:20, preferably 100:1 - 1:10, preferably, preferably 50:1-1:5, preferably 20:1 - 1:2, preferably 10:1 - 1:1, such as 10:1 and / or 1:1 (w / w; sulfur: 2ndai). In embodiments, in a composition or method of the invention, the ratio sulfur and sodium hydrogen carbonate (baking soda) as a 2ndactive ingredient (ai) is 500:1 - 1:100, preferably 400:1 - 1:50, preferably 200:1 - 1:30, preferably 100:1 - 1:20, preferably 20:1 - 1:10, preferably 2:1-1:8, preferably 1.3:1 - 1:6, preferably 1:1.5 - 1:3, such as 1:1.5 and / or 1:3 (w / w; sulfur: 2ndai). In embodiments, in a composition or method of the invention, the ratio sulfurand sunflower oil as a 2nd active ingredient (ai) is 500:1 - 1:100, preferably 400:1 -1:50, preferably 200:1 - 1:20, preferably 100:1 - 1:10, preferably 20:1 - 1:5, preferably, preferably 10:1-1:2, preferably 6:1 - 1:1, preferably 3:1 - 2:1, such as 8:3 (w / w; sulfur: 2ndai). In embodiments, in a composition or method of the invention, the ratio sulfurand lecithin as a 2nd active ingredient (ai) is 500:1 - 1:100, preferably 400:1 - 1:50,preferably 200:1 - 1:20, preferably 100:1 - 1:10, preferably 50:1 - 1:5, preferably, preferably 20:1-1:2, preferably 8:1 - 1:1, preferably 4:1 - 2:1, such as 32:11 (w / w; sulfur: 2ndai). In embodiments, in a composition or method of the invention, the ratio sulfur and neem oil as a 2ndactive ingredient (ai) is 500:1 - 1:100, preferably 400:1 - 1:100, preferably 300:1 - 1:50, preferably 200:1 - 1:20, preferably 100:1 - 1:10, preferably, preferably 50:1-1:5, preferably 40:1 – 1:2, preferably 20:1 - 1:1, such 1:1, 2:1, 5:1, 10:1 and / or 20:1 (w / w; sulfur: 2ndai). In embodiments, in a composition or method of the invention, the ratio sulfur and Bacillus, preferably Bacillus amyloliquefaciens, as a 2ndactive ingredient (ai) is 500:1 - 1:2, preferably 400:1-50:1, preferably 200:1 – 100:1, such as 200:1 and / or 100:1 (w / w; sulfur: 2ndai). In embodiments, in a composition or method of the invention, the ratio sulfur and carvacrol as a 2ndactive ingredient (ai) is 500:1 - 1:50, preferably 400:1 - 1:20, preferably 300:1 - 1:10, preferably 200:1 - 1:5, preferably 100:1 - 1:2, preferably, preferably 50:1-1:1, preferably 20:1 - 2:1, preferably 9:1 – 5.8:1, such as 9:1, 23:3 , 6.75:1 and / or 35:6 (w / w; sulfur: 2ndai). In embodiments, in a composition or method of the invention, the ratio sulfurand thymol as a 2nd active ingredient (ai) is 500:1 - 1:50, preferably 400:1 - 1:20,preferably 300:1 - 1:10, preferably 200:1 - 1:5, preferably 100:1 - 1:2, preferably, preferably 50:1-1:1, preferably 20:1 - 2:1, preferably 9:1 – 6.7:1, such as 9:1 , 23:3 and / or 6.75:1 (w / w; sulfur: 2ndai). In embodiments, in a composition or method of the invention, the ratio sulfurand acetic acid as a 2nd active ingredient (ai) is 500:1 - 1:100, preferably 400:1 -1:50, preferably 300:1 - 1:20, preferably 200:1 - 1:10, preferably 100:1 - 1:5, preferably, preferably 50:1-1:2, preferably 6:1 - 1:1, preferably 3:1-2:1, such as 2.5:1 (w / w; sulfur: 2ndai). In embodiments, in a composition or method of the invention, the ratio sulfur and copper sulfate as a 2ndactive ingredient (ai) is 500:1 - 1:100, preferably 250:1 - 1:75, preferably 100:1 - 1:20, preferably 50:1 - 1:25, preferably 20:1 - 1:20, preferably, preferably 10:1-1:10, preferably 4:1 – 1:4, preferably 2:1 – 1:2, such as 1:1 (w / w; sulfur: 2ndai). In embodiments, in a composition or method of the invention, the ratio sulfur and natamycin as a 2ndactive ingredient (ai) is 500:1 - 1:2, preferably 400:1 – 1:1, preferably 300:1 – 5:1, preferably 300:1 - 10:1, preferably 150:1 - 50:1, such as 100:1, 5:1 and / or 1:1 (w / w; sulfur: 2ndai). In embodiments, in a composition or method of the invention, the ratio sulfur and natamycin as a 2ndactive ingredient (ai) is 5:1 – 1:5 such as 1:1 (w / w; sulfur: 2ndai). In embodiments, in a composition or method of the invention, the ratio sulfur and potassium hydrogen bicarbonate as a 2ndactive ingredient (ai) is 500:1 - 1:2, preferably 400:1 - 1:2, preferably 300:1 - 1:2, preferably 200:1 - 1:2, preferably 150:1 - 10:1, preferably 75:1 - 25:1, such as 50:1(w / w; sulfur: 2ndai). In embodiments, in a composition or method of the invention, the ratio sulfur and potassium hydrogen bicarbonate as a 2ndactive ingredient (ai) is 5:1 – 1:5 such as 1:1 (w / w; sulfur: 2ndai). In embodiments, in a composition or method of the invention, the ratio sulfur and beta-1,3(4)-glucanase as a 2ndactive ingredient (ai) is 500:1 - 1:20, preferably 400:1 - 1:10, preferably 300:1 - 1:5, preferably 200:1 - 1:2, preferably 100:1 - 1:1, preferably, preferably 50:1-2:1, preferably 25:1 - 5:1, preferably 12:1 - 10:1, such as 11.2:1 (w / w; sulfur: 2ndai). In embodiments, in a composition or method of the invention, the ratio sulfur and paraffinic oil as a 2ndactive ingredient (ai) is 500:1 - 1:50, preferably 400:1 - 1:20, preferably 300:1 - 1:10, preferably 200:1 - 1:5, preferably 100:1 - 1:2, preferably 50:1 - 1:1, such as 1:1, 5:1, 10:1 and / or 50:1(w / w; sulfur: 2ndai). In embodiments, in a composition or method of the invention, the ratio sulfur and propamocarb as a 2ndactive ingredient (ai) is 500:1 - 1:50, preferably 400:1 - 1:20, preferably 300:1 - 1:10, preferably 200:1 - 1:5, preferably 100:1 - 1:2, preferably 50:1 – 1:1, such as 1:1, 10:1, 2.5:1, 12.5:1, 5:1 and / or 50:1 (w / w; sulfur: 2ndai). In embodiments, in a composition or method of the invention, the ratio sulfur and limonene as a 2ndactive ingredient (ai) is 500:1 - 1:100, preferably 400:1 - 1:90, preferably 300:1 - 1:80, preferably 200:1 - 1:70, preferably 100:1 - 1:60, preferably, preferably 50:1-1:50, preferably 20:1 - 1:20, preferably 10:1 - 1:10, such as 1:2, 1:1, 10:1, 1:10 and / or 2:1 (w / w; sulfur: 2ndai). In embodiments, in a composition or method of the invention, the ratio sulfur and garlic extract as a 2ndactive ingredient (ai) is 500:1 - 1:100, preferably 400:1 - 1:90, preferably 300:1 - 1:80, preferably 200:1 - 1:70, preferably 100:1 - 1:60, preferably, preferably 50:1-1:50, preferably 20:1 - 1:20, preferably 10:1 - 1:10, such as 1:2, 1:1, 10:1, 1:10, 1:5 and / or 2:1 (w / w; sulfur: 2ndai). In embodiments, in a composition or method of the invention, the ratio sulfur and maize oil as a 2ndactive ingredient (ai) is 500:1 - 1:100, preferably 400:1 - 1:90, preferably 300:1 - 1:80, preferably 200:1 - 1:70, preferably 100:1 - 1:60, preferably, preferably 50:1-1:50, preferably 20:1 - 1:20, preferably 10:1 - 1:10, such 1:2, 1:1, 10:1, 1:10 and / or 2:1 (w / w; sulfur: 2ndai). In embodiments, in a composition or method of the invention, the ratio sulfur and soyabean as a 2ndactive ingredient (ai) is 500:1 - 1:100, preferably 400:1 - 1:90, preferably 300:1 - 1:80, preferably 200:1 - 1:70, preferably 100:1 - 1:60, preferably, preferably 50:1-1:50, preferably 20:1 - 1:20, preferably 10:1 - 1:10, such as 1:2, 1:1, 10:1, 1:10 and / or 1:5 (w / w; sulfur: 2ndai). In embodiments, in a composition or method of the invention, the ratio sulfur and geraniol as a 2ndactive ingredient (ai) is 500:1 - 1:50, preferably 400:1 - 1:40, preferably 300:1 - 1:30, preferably 200:1 - 1:20, preferably 100:1 - 1:10, preferably 50:1 - 1:5, such as 1:1, 5:1, 50:1, 1:5 and / or 10:1 (w / w; sulfur: 2ndai). In embodiments, in a composition or method of the invention, the ratio sulfur and horsetail extract as a 2ndactive ingredient (ai) is 500:1 - 1:50, preferably 400:1 - 1:20, preferably 300:1 - 1:10, preferably 200:1 - 1:5, preferably 100:1 – 1:2, preferably 50:1 – 1:1, such as 1:1, 2:1, 5:1 and / or 50:1 (w / w; sulfur: 2ndai). In embodiments, in a composition or method of the invention, the ratio sulfur and copper oxychloride as a 2ndactive ingredient (ai) is 500:1 - 1:50, preferably 400:1 - 1:40, preferably 300:1 - 1:30, preferably 200:1 - 1:20, preferably 100:1 – 1:10, preferably 100:1 - 1:5, preferably 25:1 - 1:2, such as 5:1, 1:2, 25:1 and / or 1:1 (w / w; sulfur: 2ndai). In embodiments, in a composition or method of the invention, the ratio sulfur and zoxamide as a 2ndactive ingredient (ai) is 1000:1 - 1:50, preferably, preferably 500:1 – 1:20, 400:1 - 1:10, preferably 300:1 - 1:5, preferably 200:1 - 1:2, preferably 1000:1 – 1:1, preferably 1000:1 – 2:1, such as 1000:1, 500:1, 100:1, 10:1 or / and 2:1 (w / w; sulfur: 2ndai). In embodiments, in a composition or method of the invention, the ratio sulfur and fluopyram as a 2ndactive ingredient (ai) is 500:1 - 1:100, preferably 400:1 - 1:50, preferably 300:1 - 1:20, preferably 200:1 - 1:10, preferably 100:1 – 1:5, preferably 50:1-1:2, preferably 25:1 - 1:1, such as 25:1 and / or 1:1 (w / w; sulfur: 2ndai). In embodiments, in a composition or method of the invention, the ratio sulfur and mefentrifluconazole as a 2ndactive ingredient (ai) is 500:1 - 1:100, preferably 400:1 - 1:75, preferably 300:1 - 1:50, preferably 200:1 - 1:20, preferably 100:1 – 1:10, preferably 50:1-1:5, preferably 25:1 - 1:2, preferably 1:1-1:2, such as 1:1 and / or 1:2 (w / w; sulfur: 2ndai). In embodiments, in a composition or method of the invention, the ratio sulfur and dicloran as a 2ndactive ingredient (ai) is 500:1 - 1:100, preferably 400:1 - 1:75, preferably 300:1 - 1:60, preferably 200:1 - 1:50, preferably 100:1 – 1:20, preferably 50:1-1:10, preferably 25:1 - 1:5, preferably 5:1-1:2, such as 5:1, 1:1, and / or 1:2 (w / w; sulfur: 2ndai). In embodiments, in a composition or method of the invention, the ratio sulfur and Swinglea glutinosa plant extract as a 2ndactive ingredient (ai) is 500:1 - 1:100, preferably 400:1 - 1:75, preferably 300:1 - 1:50, preferably 200:1 - 1:20, preferably 100:1 – 1:10, preferably 50:1-1:5, preferably 25:1 - 1:2, preferably 1:1-1:2, such as 1:1 and / or 1:2 (w / w; sulfur: 2ndai). A composition according to the invention may comprise one or more surfactants. Examples of suitable surfactants are alkyl-end-capped ethoxylate glycol, alkyl-end-capped alkyl block alkoxylate glycol, dialkyl sulfosuccinate, phosphated esters, alkyl sulfonates, alkyl aryl sulfonates, tristyrylphenol alkoxylates, natural or synthetic fatty acid alkoxylates, natural or synthetic fatty alcohols alkoxylates, alkoxylated alcohols (such as n-butyl alcohol polyglycol ether), alkoxylated phosphate esters, sulfosuccinates, sodium lauryl sulfates, block copolymers (such as ethylene oxide-propylene oxide block copolymers and ethylene oxide-butylene oxide block copolymers) or combinations thereof. In a composition of the invention, said surfactant is preferably selected from an alkylnaphthalene sulfonate such as Morwet® D425 (Nouryon, Amsterdam, The Netherlands), alkoxylated phosphate esters, such as Agrilan® 1015, block copolymers such as poly(ethylene oxide)-poly(propylene oxide) block copolymers and poly(ethylene oxide)-poly(butylene oxide) block copolymers, lignin sulphonate, an alkylpolysaccharide such as GLUCOPON® 220 (BASF), dodecylbenzensulfonic acid, an acrylic copolymer such as METASPERSE 500L, a non-ionic block polymer such as a polyalkylene glycol ether, for example ATLAS™ G-5002-L, a 12 poly- hydroxysteric acid -polyethyleneglycol (PEG) block polymer such as ATLOX 4912, a PEG-poly alkyd block polymer such as ATLOX 4914, or a polymeric ester such as ATLOX 4916, a pegylated methyl methacrylate graft copolymer such as, for example, ATLOX 4913, a PEG-10 PPG-5 cetyl phosphate such as Crodafos C10 / 5A, a polysorbate such as TWEEN ® 20, TWEEN ® 22, TWEEN ® 23, TWEEN ® 24, TWEEN ® 90, di-octylsuccinate, polyoxyethylene / polypropylene, tri-stearyl sulphonate / phosphate, and an ethoxylated tristyrenephenol sulphate for example 2,4, 6 -Tris [ 1 - (phenyl) ethyl] phenyl- omega-hy dr oxypoly(oxyethylene) sulphate (Soprophor® 4D384), and ethoxylated tristyrylphenol phosphate, for example polyethylene glycol 2,4,6-tristyrylphenyl ether phosphate triethanolamine salt (Soprophor® FL), or as Soprophor® 3 D33 (Solvay), sulfosuccinate type of surfactants such as Geropon® SDS, sodium lauryl sulfates such as Galaxy® 696 G, a silicon spreader such as a nonionic organosilicon wetting spreader and any combination thereof. A composition of the invention may also comprise two or more surfactants such as an alkylnaphthalene sulfonate and an acrylic copolymer, an alkylpolysaccharide and an ethoxylated tristyrenephenol phosphate, a non-ionic block polymer and a block polymer, or lignin sulphonate and a non-ionic block polymer. A surfactant or surfactants are preferably present in an amount of 0.1 up to 50 % (w / v), more preferred 1 to up to 25 % (w / v), more preferred 3 to up to 15 % (w / v), such as 4 % (w / v), 5 % (w / v), 6 % (w / v), 7 % (w / v), 8 % (w / v), 9 % (w / v), 10 % (w / v), 11 % (w / v), 12 % (w / v), 13 % (w / v) and 14 % (w / v). A composition of the invention comprises sulfur as a first active ingredient, further comprising a second active ingredient. In embodiments, said composition comprises between 0.1 and 850 gram / L of sulfur, including 0.5 - 700 gram / L of sulfur, such as 1 - 600 gram / L of sulfur, 5 - 600 gram / L of sulfur, 10 - 500 gram / L of sulfur, 50 - 400 gram / L of sulfur, 100 - 300 gram / L of sulfur. In embodiments, said composition comprises 400 - 500 gram / L of sulfur. In embodiments, a composition of the invention comprises 0.0002 - 850 gram / L of second active ingredient (2ndai), including 0.001 - 700 gram / L of 2ndai, such as 0.01 - 600 gram / L of 2ndai, 0.5 - 600 gram / L of 2ndai, 1 -and 500 gram / L of 2ndai, 2 - 400 gram / L of 2ndai, 10 - 300 gram / L of 2ndai, 20 - 200 gram / L of 2ndai, 50 - 100 gram / L of 2ndai. In embodiments, a composition of the invention comprises 0.1 - 850 gram / L of sulfur and 0.0002 - 850 gram / L of (2ndai), including 0.5 - 700 gram / L of sulfur and 0.001 - 700 gram / L of 2ndai, such as 1 - 650 gram / L of sulfur and 0.05 - 650 gram / L of 2ndai, 30 - 600 gram / L of sulfur and 3 - 600 gram / L of 2ndai, 40 -and 600 gram / L of sulfur and 4 - 600 gram / L of 2ndai, 50 - 500 gram / L of sulfur and 5 - 500 gram / L of 2ndai, 100 - 400 gram / L of sulfur and between 10 - 400 gram / L of 2ndai, 200 - 300 gram / L of sulfur and 20 - 300 gram / L of 2nd ai. In embodiments, said composition comprises 400 - 500 gram / L of sulfur and 20 - 300 gram / L of 2ndai. A composition of the invention comprises sulfur as a first active ingredient, further comprising a second active ingredient. In embodiments, said composition comprises between 0.1 and 850 gram / kg of sulfur, including 0.5 - 700 gram / kg of sulfur, such as 1 - 600 gram / kg of sulfur, 5 - 600 gram / kg of sulfur, 10 - 500 gram / kg of sulfur, 50 - 400 gram / kg of sulfur, 100 - 300 gram / kg of sulfur. In embodiments, said composition comprises 400 - 500 gram / kg of sulfur. In embodiments, a composition of the invention comprises 0.0002 - 850 gram / kg of second active ingredient (2ndai), including 0.001 - 700 gram / kg of 2ndai, such as 0.01 - 600 gram / kg of 2ndai, 0.5 - 600 gram / kg of 2ndai, 1 -and 500 gram / kg of 2ndai, 2 - 400 gram / kg of 2ndai, 10 - 300 gram / kg of 2ndai, 20 - 200 gram / kg of 2ndai, 50 - 100 gram / kg of 2ndai. In embodiments, a composition of the invention comprises 0.1 - 850 gram / kg of sulfur and 0.0002 - 850 gram / kg of (2ndai), including 0.5 - 700 gram / kg of sulfur and 0.001 - 700 gram / kg of 2ndai, such as 1 - 650 gram / kg of sulfur and 0.05 - 650 gram / kg of 2ndai, 30 - 600 gram / kg of sulfur and 3 - 600 gram / kg of 2ndai, 40 -and 600 gram / kg of sulfur and 4 - 600 gram / kg of 2ndai, 50 - 500 gram / kg of sulfur and 5 - 500 gram / kg of 2ndai, 100 - 400 gram / kg of sulfur and between 10 - 400 gram / kg of 2ndai, 200 - 300 gram / kg of sulfur and 20 - 300 gram / kg of 2nd ai. In embodiments, said composition comprises 400 - 500 gram / kg of sulfur and 20 - 300 gram / kg of 2ndai. In embodiments, a composition of the invention comprises sulfur with an average volume particle size of less than 25 micrometer, less than 20 micrometer, less than 15 micrometer, less than 10 micrometer, such as less than 9 micrometer, less than 8 micrometer, less than 7 micrometer, less than 6 micrometer, less than 5 micrometer, less than 4 micrometer, less than 3 micrometer, less than 2.5 micrometer, less than 2 micrometer, or less than 1 micrometer. In embodiments, a composition of the invention comprises sulfur with an average particle size of more than 1 micrometer, more than 2 micrometer, more than 5 micrometer, more than 10 micrometer, such as more than 15 micrometer, or more than 20 micrometer. Methods for determining the average particle size of sulfur particles are known in the art and include, for example, determining the actual size and morphology of the particles using a camera system, and the use of laser diffraction and dynamic light scattering. A preferred method employs volume-based particle size determination, for example by laser diffraction. A suitable apparatus for laser diffraction is an ANALYSETTE 22 MicroTec plus particle size analyser. Active ingredients for use in methods or compositions of the invention The invention provides a composition comprising sulfur and a 2ndactive ingredient (2ndai) as well as methods wherein sulfur and a 2ndai are applied. A skilled person understands that a 2ndai of the invention can be categorized in different ways. For example, a 2ndai can be categorized based on its activity as such a 2ndai can be a such as a fungicide and / or a nematicide, or a 2ndai can be categorized based on its mode of action using for example FRAC and / or Nematicide Mode of Action Classification Scheme, identified by N-codes such as outlined in the Insecticide Resistance Action Committee’s (IRAC) Mode of Action Classification Scheme (Version 2.1, which can be downloaded from the IRAC website, available at irac-online.org / ). Alternatively, a 2ndai can be categorized based on its origin as such a 2ndai can be a chemical compound, a natural compound and a microorganism, including an extract of a microorganism, and a combination thereof. A person skilled in the art knows that certain compounds can have an effect on more than one pesticidal group, such as compounds having a fungicidal and bactericidal activity, compounds having a fungicidal and insecticidal activity, compounds having a fungicidal and acaricidal activity, compounds having a fungicidal and nematicidal activity, compounds having a bactericidal and insecticidal activity, compounds having a bactericidal and acaricidal activity, compounds having a bactericidal and nematicidal activity, compounds having a insecticidal and acaricidal activity, compounds having a insecticidal and nematicidal activity, compounds having a acaricidal and nematicidal activity, compounds having a fungicidal, bactericidal and insecticidal activity, compounds having a fungicidal, bactericidal and acaricidal activity, compounds having a fungicidal, bactericidal and nematicidal activity, compounds having a fungicidal, insecticidal and acaricidal activity, compounds having a fungicidal, insecticidal and nematicidal activity, compounds having a fungicidal, acaricidal and nematicidal activity, compounds having a bactericidal, insecticidal and acaricidal activity, compounds having a bactericidal, insecticidal and nematicidal activity, compounds having a bactericidal, acaricidal and nematicidal activity, compounds having a insecticidal, acaricidal and nematicidal activity, compounds having a fungicidal, bactericidal, insecticidal and acaricidal activity, compounds having a fungicidal, bactericidal, insecticidal and nematicidal activity, compounds having a fungicidal, bactericidal, acaricidal and nematicidal activity, compounds having a fungicidal, insecticidal, acaricidal and nematicidal activity, compounds having a bactericidal, insecticidal, acaricidal and nematicidal activity and compounds having a fungicidal, bactericidal, insecticidal, acaricidal and nematicidal activity. For example, fluopyram is a compound having a nematicidal and fungicidal activity. For example, garlic extract is a compound having a nematicidal and fungicidal activity. The 2ndai in a composition of the invention can be a pesticide, such as a fungicide, a nematicide, or a combination thereof. In embodiments, the 2ndai in a composition of the invention is a fungicide. In embodiments, the 2ndai in a composition of the invention is selected from a compound, including a natural compound, and a microorganism, including an extract of a microorganism, and a combination thereof. In embodiments, the 2ndai is a natural compound selected from an enzyme such as beta-glucanase preferably beta-1,3(4)-glucanase, chitosan, chitosan hydrochloride, COS-OGA (a mixture of chito-oligosaccharides and oligo- galacturonic acid), onion extract, nettle extract, mustard extract, horsetail extract (Equisitum arvense), silicic acid, willow extract, fructose, sucrose, clove oil, Swinglea glutinosa extract, sodium hydrogen carbonate, sunflower oil, maize oil, soyabean oil, onion oil, lecithin, neem oil (comprising azadirachtin), activated charcoal, bentonite, thymol, carvacrol, eugenol, geraniol, limonene, acetic acid, copper sulfate, natamycin, potassium hydrogen bicarbonate, paraffinic oil, aluminum sulfate, garlic extract (comprising allicin), a fatty acid, a phosphonate or salt thereof, laminarin and any combination thereof. In embodiments, the 2ndai is not a chitosan oligosaccharide. Examples of a suitable 2ndai such as a fungicide include a compound such as pyrimethanil (4,6-dimethyl-N-phenylpyrimidin-2-amine), boscalid (2-chloro-N-(4'- chloro[1,1'-biphenyl]-2-yl)pyridine-3-carboxamide), pydiflumetofen (3- (difluoromethyl)-N-methoxy-1-methyl-N-[1-(2,4,6-trichlorophenyl)-2-propanyl]-1H- pyrazole-4-carboxamide), metalaxyl-M (methyl (2R)-2-(N-(2-methoxyacetyl)-2,6- dimethylanilino)propanoate), Folpet (2-[(tricloromethyl)sulfanyl]-1H-isoindole- 1,3(2H)-dione), propamocarb (propyl [3-(dimethylamino)propyl]carbamate), mandipropamid (2-(4-chlorophenyl)-N-[2-(3-methoxy-4-prop-2-ynoxyphenyl)ethyl]- 2-prop-2-ynoxyacetamide), fluopicolide (2,6-dichloro-N-[[3-chloro-5- (trifluoromethyl)pyridin-2-yl]methyl]benzamide), dithianon (5,10- dioxobenzo[g][1,4]benzodithiine-2,3-dicarbonitrile), dicloran (2, 6-dichloro-4- nitroaniline), fluopyram (N-{2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]ethyl}-2- (trifluoromethyl)benzamide), benthiavalicarb isopropyl (propan-2-yl N-[(2S)-1- [[(1R)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethyl]amino]-3-methyl-1-oxobutan-2- yl]carbamate), dodine (acetic acid;2-dodecylguanidine), fluopyram (N-{2-[3-chloro-5- (trifluoromethyl)pyridin-2-yl]ethyl}-2-(trifluoromethyl)benzamide), zoxamide (3,5- dichloro-N-(3-chloro-1-ethyl-1-methyl-2-oxopropyl)-4-methylbenzamide), bixafen (N-[2-(3,4-dichlorophenyl)-4-fluorophenyl]-3-(difluoromethyl)-1-methylpyrazole-4- carboxamide), copper oxychloride, thifluzamide (N-[2,6-dibromo-4- (trifluoromethoxy)phenyl]-2-methyl-4-(trifluoromethyl)-1,3-thiazole-5- carboxamide), isopyrazam (3-(difluoromethyl)-1-methyl-N-(11-propan-2-yl-3- tricyclo[6.2.1.02,7]undeca-2(7),3,5-trienyl)pyrazole-4-carboxamide), adepidyn (pydiflumetofen; 3-(difluoromethyl)-N-methoxy-1-methyl-N-[1-(2,4,6- trichlorophenyl)-2-propanyl]-1H-pyrazole-4-carboxamide), mefentrifluconazole, and metconazole (5-[(4-chlorophenyl)methyl]-2,2-dimethyl-1-(1,2,4-triazol-1- ylmethyl)cyclopentan-1-ol). In examples, a suitable 2ndai that is active as an acaricide and as a nematicide includes a compound such as an avermectin, which is a 16-membered macrocyclic lactone derivative with anthelmintic and insecticidal properties. A suitable avermectin is abamectin, a mixture of: (10E,14E,16E)- (1R,4S,5′S,6S,6′R,8R,12S,13S,20R,21R,24S)-6′-[(S)-sec-butyl]-21,24-dihydroxy- 5′,11,13,22-tetramethyl-2-oxo-(3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa- 10,14,16,22-tetraene)-6-spiro-2′-(5′,6′-dihydro-2′H-pyran)-12-yl 2,6-dideoxy-4-O- (2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-3-O-methyl-α-L-arabino- hexopyranoside and (10E,14E,16E)-(1R,4S,5′S,6S,6′R,8R,12S,13S,20R,21R,24S)- 21,22-dihydroxy-6′-isopropyl-5′,11,13,22-tetramethyl-2-oxo-(3,7,19- trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene)-6-spiro-2′-(5′,6′- dihydro-2′H-pyran)-12-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-α-L-arabino- hexopyranosyl)-3-O-methyl-α-L-arabino-hexopyranoside). In examples, the 2nd ai is an enzyme, preferably a hydrolytic enzyme such as a glucanase, including a beta-glucanase and a lichenase. In embodiments, the glucanase is a cellulotic or a non-cellulolytic glucanase. In embodiments, said glucanase is an endo-1,3-^-glucanase (EC 3.2.1.39), or an endo-1,3 (4)-^-glucanase (EC 3.2.1.6), or a endo-1,4-^-glucanase (EC 3.2.1.4), which includes a kitalase and a laminaranase that may aid in a pathogen defense mechanism by hydrolyzing substrates like glucan, curdlan, laminarin, lichenin, paramylon and pachyman. In embodiments, said glucanase may be a mutant glucanase, such as for example an N54W mutant of ^-1,3-glucanase BglS27 with a 3.6-fold higher specific activity (Gao et al., 2023. LWT 187: 115342). In embodiments, said glucanase is a free glucanase and may be present in the composition when substantially free of intact cells. In embodiments, said glucanase is present in the composition in the presence of intact cells. In examples, the 2ndai is a microorganism selected from a Trichoderma species, a Bacillus species, a Rhizobium species such as R. leguminosarum, and any combination thereof. A suitable Trichoderma species may be selected from T. asperellum, T. harzianum, T. atroviride and any combination thereof. A suitable Bacillus species may be selected from B. thuringiensis, B. amyloliquefaciens, B. thuringiensis, B. subtilis, B. pumilus and any combination thereof. A microorganism as 2ndai may function as biological control by, for example, the induction of a systemic immune response in plants, competition with the pest for nutrients and space, production of volatile and non-volatile antibiotics, and production of hydrolytic enzymes. Said microorganism may be present as a spore, or as spores, in a composition of the invention. Bacillus species are known to form spores, especially under stress conditions, such as dryness, high temperature, and under restricted nutrient conditions. Trichoderma species also form spores, termed conidia, by asexual reproduction. Triggers that are known to induce conidiation of Trichoderma species include a combination of factors such as light, endogenous rhythms, C : N status, the ambient pH of the growth medium, extracellular calcium, physical injury to the mycelium and the presence of fungal-derived volatile organic compounds (Steyaert et al., 2010. Microbiol 156: 2887–2900). The term “microorganism”, as is used herein, includes reference to an extract of a microorganism, such as a yeast-based substance. A suitable extract of a microorganism is provided by an extract comprising cell walls of a yeast such as Saccharomyces cerevisiae. An example is provided by CEREVISANE®, a whole cell wall extract of Saccharomyces cerevisiae strain LAS117. Cerevisane may act as a systemic resistance inducer (SRI) that aids in the up-regulation of plant defense genes resulting in physiological changes, including the reinforcement of plant cell walls and the production of antimicrobial compounds such as hydrogen peroxide and phytoalexins. In embodiments, a composition of the invention comprising a microorganism as a 2ndai may comprise glycerol. Glycerol may be used as a cryoprotectant for preservation of said microorganism. In addition, glycerol may be used as a carbon source during growth of said microorganism, prior to the inclusion of said microorganism in a composition of the invention. In embodiments, in a composition or method of the invention, the 2ndai is selected from selected from clove oil, zoxamide, pydiflumetofen, metalaxyl-M, folpet, propamocarb, fluopyram, mandipropamid, fluopicolide, dithianon, dicloran, benthiavalicarb isopropyl, bixafen, thifluzamide, isopyrazam, adepidyn, mefentrifluconazole, metconazole, copper oxychloride, an enzyme such as beta- glucanase preferably beta-1,3(4)-glucanase, pyrimethanil, boscalid, abamectin, dodine, chitosan, copper sulfate, chitosan hydrochloride, COS-OGA, onion extract, nettle extract, mustard extract, horsetail extract, silicic acid, willow extract, swinglea glutinosa extract, fructose, sucrose, sodium hydrogen carbonate, calcium hydroxide, magnesium hydroxide, sunflower oil, maize oil, soyabean oil, onion oil, lecithin, neem oil, activated charcoal, bentonite, thymol, carvacrol, eugenol, geraniol, limonene, acetic acid, natamycin, potassium hydrogen bicarbonate, paraffinic oil, aluminium sulfate, fatty acid, garlic extract, a phosphonate or a salt thereof, laminarine and a microorganism, including an extract of a microorganism, selected from a Trichoderma species, a yeast-based substance, a Bacillus species such as B. amyloliquefaciens, a Rhizobium species, and any combination thereof. In embodiments, in a composition or method of the invention, the 2ndai is selected from clove oil, zoxamide, pydiflumetofen, metalaxyl-M, folpet, propamocarb, fluopyram, mandipropamid, fluopicolide, dithianon, dicloran, benthiavalicarb isopropyl, bixafen, thifluzamide, isopyrazam, adepidyn, mefentrifluconazole, metconazole, an enzyme such as beta-glucanase preferably beta-1,3(4)-glucanase, chitosan, chitosan hydrochloride, COS-OGA, onion extract, nettle extract, mustard extract, horsetail extract, silicic acid, willow extract, swinglea glutinosa extract, fructose, sucrose, sodium hydrogen carbonate, calcium hydroxide, magnesium hydroxide, sunflower oil, maize oil, soyabean oil, onion oil, lecithin, neem oil, activated charcoal, bentonite, thymol, carvacrol, eugenol, geraniol, limonene, acetic acid, natamycin, potassium hydrogen bicarbonate, paraffinic oil, aluminium sulfate, fatty acid, garlic extract, a phosphonate or a salt thereof, laminarine and a microorganism, including an extract of a microorganism, selected from a Trichoderma species, a yeast-based substance, a Bacillus species such as B. amyloliquefaciens, a Rhizobium species, and any combination thereof. In embodiments, in a composition or method of the invention, the 2ndai is selected from clove oil, zoxamide, pydiflumetofen, metalaxyl-M, propamocarb, fluopyram, dicloran, mefentrifluconazole, copper oxychloride, beta-1,3(4)-glucanase, pyrimethanil, boscalid, abamectin, chitosan, copper sulfate, horsetail extract, swinglea glutinosa extract, sodium hydrogen carbonate, sunflower oil, maize oil, soyabean oil, lecithin, neem oil, thymol, carvacrol, geraniol, limonene, acetic acid, natamycin, potassium hydrogen bicarbonate, paraffinic oil, garlic extract, a yeast- based substance, a Bacillus species such as B. amyloliquefaciens, and any combination thereof. In embodiments, in a composition or method of the invention, the 2ndai is selected from clove oil, zoxamide, pydiflumetofen, metalaxyl-M, propamocarb, fluopyram, dicloran, mefentrifluconazole, beta-1,3(4)-glucanase, chitosan, horsetail extract, swinglea glutinosa extract, sodium hydrogen carbonate, sunflower oil, maize oil, soyabean oil, lecithin, neem oil, thymol, carvacrol, geraniol, limonene, acetic acid, natamycin, potassium hydrogen bicarbonate, paraffinic oil, garlic extract, a yeast-based substance, a Bacillus species such as B. amyloliquefaciens, and any combination thereof. As explained herein above, it is hypothesized that synergy is observed when sulfur is combined with a 2ndactive ingredient that is able to alter or inhibit enzymatic and protein activity in a pest cell. Examples of a 2ndactive ingredient that is able to alter or inhibit enzymatic and protein activity is a fungicidal pesticide such as one of those listed in the FRAC Code List with target codes A, B, C, D, F, G, H, I, M, P, U, NC, BM01 and BM02, as well as compounds with unknown or multiple sites of action and other compounds that can influence enzymes and / or proteins in a pest cell. As such, a 2ndai of the invention may be selected from the group consisting of a fungicide acting on the nucleic acid metabolism (Group A, FRAC), a fungicide acting on the cytoskeleton and motor proteins (Group B, FRAC), a fungicide acting on the respiration (Group C, FRAC), a fungicide acting on the amino acid and protein synthesis (Group D, FRAC), a fungicide acting on lipid synthesis or transport / membrane integrity or function (Group F, FRAC), a fungicide acting on the sterol biosynthesis in membranes (Group G, FRAC), a fungicide acting on the cell wall biosynthesis (Group H, FRAC), a fungicide acting on melanin synthesis in the cell wall (Group I, FRAC), a fungicide with a multi-site activity (Group M, FRAC), a fungicide as an inducer of plant defense (Group P, FRAC), a fungicide belonging to the group of fungicides with an unknown mode of action (Group U, FRAC), a biological with multiple mode of action such as a plant extract (Group BM01, FRAC) and microorganism (Group BM02, FRAC), mineral oils and organic oils (FRAC group NC) and any combination thereof. In embodiments, a 2ndai is a fungicidal pesticide acting on the nucleic acid metabolism (FRAC group A) which includes acylalanines (Group 4, FRAC), butyrolactones (Group 4, FRAC) and / or oxazolidinone (Group 4, FRAC), such as metalaxyl, metalaxyl-M and / or mefenoxam. Without being bound by theory, metalaxyl-M has a direct enzymatic target as it specifically inhibits the protein RNA polymerase I in pests, which blocks rRNA synthesis, which in turn prevents ribosome formation and protein synthesis. Without functional ribosomes, the pest cannot produce essential enzymes or proteins, which may lead to growth arrest and death. In embodiments, a 2ndai is a fungicidal pesticide acting on the cytoskeleton and motor proteins (FRAC group B) such as a benzimidazole (Group 1, FRAC) and / or thiophanates (Group 1, FRAC), and / or a pyridinylmethyl benzamide (Group 43, FRAC). A preferred benzimidazole is carbendazim, zoxamide and / or thiabendazole. A preferred thiophanate is thiophanate and / or thiophanate-methyl. A preferred pyridinylmethyl benzamide is fluopicolide. In embodiments, a 2ndai is a fungicidal pesticide acting on the respiration (FRAC group C) such as a member of Group 11 FRAC, Group 7 FRAC and / or Group 29 FRAC. Group 11 FRAC fungicides are Quinone outside inhibitors (QoI fungicides). A preferred fungicide acting on the respiration of Group 11 FRAC is azoxystrobin, fluoxastrobin, pyraclostrobin, trifloxystrobin and / or kresoxim-methyl. Group 7 FRAC fungicides are fungicides belonging to the succinate dehydrogenase inhibitors (SDHI). A preferred fungicide acting on the respiration of Group 7 FRAC is fluxapyroxad, boscalid, penthiopyrad, fluopyram, adepidyn (N-methoxy- (phenethyl)-pyrazole-carboxamide), carboxin, bixafen, sedaxane, inpyrfluxam, pydiflumetofen, thifluzamide and / or isopyrazam. Group 29 FRAC fungicides are uncouples of oxidative phosphorylation, such as fluazinam. Without being bound by theory, boscalid and pydiflumetofen have a direct effect on pests such as pathogenic fungi as they bind specifically to the succinate dehydrogenase enzyme (complex II) in the mitochondrial respiratory chain and by doing so kills the pest. In embodiments, a 2ndai is a fungicidal pesticide acting on the amino acid and protein synthesis (FRAC group D) such as an anilino-pyrimidines (AP fungicides, Group 9, FRAC) such as cyprodinil and pyrimethanil. Pyrimenthanil can inhibit amino acids and protein synthesis, especially methionine biosynthesis, leading to the death of a pest such as a pathogenic fungus. In embodiments, a 2ndai is a fungicidal pesticide acting on lipid synthesis or transport / membrane integrity or function (FRAC group F) including a carbamate (Group 28, FRAC) such as prothiocarb, dicloran and propamocarb, and / or a polyene (Group 48, FRAC), such as natamycin. Without being bound by theory, in pest cells, natamycin can bind to ergosterol, which is critical for the correct structure and function of many membrane proteins (transporters, channels, receptors). After binding of natamycin to ergosterol, those proteins cannot function properly and nutrient uptake (e.g., glucose, amino acids) is blocked. Disturbance of ergosterol- protein interactions indirectly affects intracellular signaling pathways leading to inhibition of the fungal pathogen. Furthermore, and without being bound by theory, propamocarb may act directly on pest such as fungal enzymes which are related to pest metabolism, although the exact enzymatic target is not fully characterized. Suggested is that propamocarb inhibits enzymes involved in lipid and phospholipid biosynthesis, disrupting cell membrane formation, which may lead to impaired membrane integrity, defective growth, and metabolic arrest. In embodiments, the 2ndai is a fungicidal pesticide acting on the sterol biosynthesis in membranes (FRAC group G) including Group 3 FRAC fungicides which are “C14-demethylase in sterol biosynthesis” including compounds such as triazole, piprazine, pyridine, pyrimidine, triazolinthione and imidazole. A preferred triazole is tebuconazole, propiconazole, metconazole, mefentrifluconazole, difenoconazole and / or tetraconazole. A preferred imidazole is imazalil and / or prochloraz. A preferred triazolinthione is prothioconazole. Without being bound by theory, mefentrifluconazole may have a direct inhibitory effect onenzymes such as fungal enzyme lanosterol 14α-demethylase (CYP51), a cytochrome P450 enzyme. This inhibition blocks ergosterol biosynthesis, which is essential for fungal cell membranes. Because of the impaired protein / enzyme functions fungal growth arrests. In embodiments, a 2ndai is a fungicidal pesticide acting on the cell wall biosynthesis (FRAC group H) including a polyoxin (Group 19, FRAC), such as polyoxin, and / or a carboxylic acid amines (CAA, Group 40, FRAC) such as pyrimorph, mandipropamid and / or benthiavalicarb. In embodiments, a 2ndai is a fungicidal pesticide with a multi-site activity (FRAC group M) that belongs to the group of dithiocarbamates (Group M03, FRAC), such as mancozeb, thiram, ziram, zineb, metiram, propineb, to the group of inorganic Group M01 such as copper, and copper compounds for example copper sulfate and copper oxychloride, to the group of inorganic group M02 such as sulfur, to the group of chloronitriles (Group M05) such as chlorothalonil, to the group of anthraquinones (Group M09) such as dithianon and / or to the group of phthalimides (Group M04) such as folpet, captafol, and captan. For example, folpet is a pesticide with a direct effect on pests such as pathogenic fungi, by reacting with the thiol (– SH) groups in proteins and enzymes in pests. Without being bound by theory, copper compounds like copper hydroxide, copper oxychloride and copper sulfate all act as multi-site contact biocides, and their effects on pests such as fungi, oomcytes, and nematodes are linked to direct protein / enzymatic toxicity through copper ions as follows. Copper ions bind to thiol (-SH) groups in proteins which denatures enzymes and structural proteins. Next, copper may cause oxidative stress (generation of reactive oxygen species), which damages proteins, lipids, and DNA. Finally, copper may disrupt membrane-bound enzymes in respiration and other metabolic pathways. In embodiments, a 2ndai is a fungicidal pesticide as an inducer of plant defense (FRAC group P) that belongs to the group of salicylate related fungicides (Groups P01 and P02, FRAC) such as acibenzolar-S-methyl, and probenazole, the group of polysaccharide elicitors (Group P04, FRAC) such as laminarin, to the group of microbial elicitors (Group P06) such as Bacillus mycoides and the cell walls of Saccharomyces cerevisiae, and / or to the group of phosphonates (Group P07, FRAC), such as fosetyl-al, mono and di-potassium phosphonate, and disodium phosphonate. In embodiments, a 2ndai is a fungicidal pesticide of the group of fungicides with an unknown mode of action (FRAC group U) such as cymoxanil, dodine, and / or validamycin. In embodiments, a 2ndai is a fungicidal pesticide of the group of biologicals with multiple modes of action is a plant extract (FRAC group BM01) such as a phenol, sesquiterpene, coumarin, terpene hydrocarbon, terpenes alcohol, and / or terpene phenol. Such plant extract can be a crude plant extract itself or an essential oil that is purified from a plant extract derived from a plant. A plant extract comprises or may be but is not limited to thymol, carvacrol, eugenol, geraniol, limonene, menthol, citral, terpinene, onion extract, nettle extract, mustard extract, horsetail extract, garlic extract, Swinglea glutinosa extract, willow extract; and oils like thyme oil, basilic oil, clove oil, mint oil, lemon grass oil, citrus oil, onion oil, neem oil, soybean oil, maize oil, sunflower oil and / or pine oil. It also includes cinnamaldehyde and / or the extract derived from cinnamon oil. Without being bound by theory, terpenes, such as eugenol in clove oil, geraniol, carvacrol, thymol, limonene, may have a direct toxic effect on enzymes and proteins in pests such as pathogenic fungi as terpenes damage membranes which leads to leakage of proteins. Terpenes may also directly inactivate pest enzymes such as fungal enzymes (respiratory, hydrolytic, transport). Without being bound by theory, plant oils such as soyabean oil, maize oil, sunflower oil may have indirect effects on enzymes of pests like pathogenic fungi, as they may coat the surface of the pest and smothers them. For example, an oil can cover fungal spores or hyphae, limiting oxygen, moisture, and nutrient exchange which indirectly inactivate enzymatic systems. Furthermore, an oil can disrupt membranes of pests. In embodiments, a 2ndai is a fungicidal pesticide including mineral oils and organic oils (FRAC group NC) including paraffinic oil. Without being bound by theory, paraffinic oil may be toxic for pests such as fungi and insects via physical / mechanical mechanisms, which indirectly affect proteins and enzymes by disrupting the living environment of the pest. This can be via coating and / or suffocation, for example oils block spiracles (respiratory openings) in insects and this may lead to oxygen deprivation leading to metabolic enzyme activity collapses. Also, paraffinic oil can dissolve or disturb cuticular lipids and thereby indirectly destabilize membrane-bound proteins and enzymes. Furthermore, desiccation by paraffinic oil may lead to secondary protein / enzyme denaturation. In embodiments, a 2ndai is a biological with multiple mode of action such as fungicide selected from the group of micro-organisms (FRAC group BM02), which include Trichoderma spp. such as Saccharomyces sp., Pseudomonas spp., Rhizobium spp., Bacillus spp, such as Trichoderma asperellum, T. harzianum, T. atroviride, Purpurreocillium spp., B. subtilis, B. firmus, B. amyloliquefaciens, B.pulilus, B. thuringiensis, R. leguminosarum and combination thereof.Without being bound by theory, Bacillus amyloliquefaciens can produce metabolites that directly attack pest proteins and enzymes. For example, lipopeptides (such as iturin, fengycin, surfactin) may insert into fungal membranes and cause leakage of proteins / enzymes. Proteases secreted by Bacillus degrade fungal cell wall proteins. B amyloliquefaciens also indirectly induces production of plant defense enzymes such as chitinases, peroxidases, that affect fungal proteins. Without being bound by theory, a Bacillus species such as Bacillus thuringiensis can have a direct protein-targeting action as it produces toxins such as Cry and Cyt toxins during sporulation. After ingestion by a pest such as an insect, the crystals dissolve and proteases (e.g. trypsin-like enzymes) activate Cry protoxins into toxic proteins, which may lead to cell lysis, protein leakage, and pest death. Without being bound by theory, Rhizobium leguminosarum can suppress pathogenic pests such as fungi indirectly through induction of plant defenses (systemic resistance), which may increase plant production of chitinases, and / or peroxidases. These plant enzymes attack pests such as fungal cell walls and indirectly affect pests proteins / enzymes. Without being bound by theory, a Trichoderma species such as Trichoderma harzianum has direct effects on fungal enzymes / proteins as it produces hydrolytic enzymes (e.g. chitinases, proteases, cellulases) that degrade fungal cell wall proteins (and polysaccharides). Furthermore, a Trichoderma species such as T. harzianum can coil around fungal hyphae, can penetrate, and can secrete enzymes that directly lyse proteins in pest cells. Furthermore, a Trichoderma species may have indirect effects on pest proteins as it stimulates plant defense enzymes (e.g., chitinases, peroxidases) that further attack pest proteins. In embodiments, the 2ndai is a microorganism or an extract of a microorganism such as a yeast-based substance, for example a cell wall or component thereof. Without being bound by theory, such yeast-based substance may have an inhibitory effect on a pest such as a pathogenic fungus via an indirect effect on enzymes and / or other proteins as it may trigger a burst of reactive oxygen species that oxidatively damages proteins of fungal pathogens, which inhibits their development and growth. Examples of a 2ndactive ingredient that is able to alter or inhibit enzymatic and protein activity is a nematode such as outlined in the Nematicide Mode of Action Classification Scheme, identified by N-codes, is a classification of nematicides into groups based on their mode of action, provided by the IRAC. Used herein is Nematicide Mode of Action Classification Scheme Version 2.1, which can be downloaded from the IRAC website (available at irac-online.org / ). As such, a 2ndai of the invention may be selected from an allosteric modulator of a glutamate- gated chloride channel (N-2). In embodiments, the a 2ndai is an allosteric modulator of a glutamate-gated chloride channel (N-2) which is thought to act on the nervous system of nematodes. A preferred allosteric modulator of a glutamate-gated chloride channel is an avermectin and / or milbemycin. A preferred avermectin is abamectin. Without being bound by theory, abamectin is a nematicide and may have direct toxic effects on proteins of pest cells such as nematode cells, more specifically the targets of abamectin are proteins such as ion channel receptors. Abamectin can bind to the glutamate-gated chloride channels (GluCl) in nerve and muscle cells of pests such as nematodes, which may lead to hyperpolarization of the membrane, paralysis, and death; abamectin can also interact with GABA-gated chloride channels, enhancing inhibitory signalling. In embodiments, the 2ndai is a compound that can influence enzymes and / or proteins in a pest, selected from the group consisting of beta-glucanase, chitosan, chitosan hydrochloride, COS-OGA, silicic acid, fructose, sucrose, sodium hydrogen carbonate, calcium hydroxide, magnesium hydroxide, lecithin, activated charcoal, betnonite, acetic acid, potassium hydrogen bicarbonate, aluminium sulfate and fatty acid. In embodiments, the a 2ndai is a beta-glucanase, preferably a beta-1,3(4)- glucanase. Without being bound by theory, beta-glucanase such as beta-1,3(4)- glucanase may act via damaging the pest cell wall such as the fungal cell wall, making the pest cells more permeable and fragile. This causes leakage of intracellular proteins / enzymes and exposes the pests to other defense compounds (e.g., chitinases, ROS, phytoalexins). In embodiments, the a 2ndai is chitosan. Without being bound by theory, the positive charge of chitosan allows it to bind to negatively charged proteins, leading to conformational changes and enzyme inactivation. Chitosan has been reported to inhibit fungal proteases and hydrolytic enzymes, further impairing pathogenicity. In embodiments, the a 2ndai is a sodium hydrogen carbonate (baking soda). Without being bound by theory, baking soda acts on pests such as fungi via raising the extracellular pH. Many fungal enzymes (e.g., hydrolases, proteases) are highly pH-dependent. Alkaline conditions lead to denaturation or inactivation of fungal enzymes involved in growth, metabolism, and pathogenicity. Disruption of membrane potential and ion homeostasis also stresses proteins associated with transport and energy metabolism. In embodiments, the a 2ndai is lecithin. Without being bound by theory, lecithin has indirect effects on proteins and enzymes as it may alter membrane fluidity, which indirectly affects membrane-bound proteins / enzymes in pests like fungi. In embodiments, the a 2ndai is acetic acid. Without being bound by theory, acetic acid acts via low pH. Undissociated acetic acid penetrates a pest cell such as a fungal cell membrane and once inside the more neutral cytoplasm, it dissociates into acetate and protons, which may cause cytoplasmic acidification, leading to: denaturation of proteins and enzymes. Furthermore, acetic acid can inhibit enzyme activity that depends on narrow pH ranges (e.g., glycolytic and respiratory enzymes). Furthermore, acetate ions can interfere with metabolic pathways by inhibiting certain enzymes, e.g., in the TCA cycle (tricarboxylic acid cycle). In embodiments, the a 2ndai is potassium hydrogen bicarbonate. Without being bound by theory, potassium hydrogen bicarbonate (KHCO₃) raises the extracellular pH and can alter the osmotic balance in pests such as pathogenic fungi. Alkaline stress denaturates pH-sensitive fungal enzymes, reducing their activity. Also, membrane integrity may be compromised, leading to leakage of intracellular enzymes / proteins. In preferred embodiments, the 2ndai is a compound selected from FRAC group A such as metalaxyl-M; FRAC group B such as zoxamide, FRAC group C such as fluopyram, boscalid and / or pydiflumetofen; FRAC group D such as pyrimethanil; FRAC group F such as dicloran, propamocarb and / or natamycin; FRAC group G such as mefentrifluconazole; FRAC group BM01 such as clove oil, horsetail extract, sunflower oil, maize oil, soyabean oil, neem oil, thymol, carvacrol, geraniol, limonene, Swinglea glutinosa extract and / or garlic extract; FRAC group BM02 such as a Bacillus species preferably B. amyloliquefaciens, and / or a yeast-based substance e.g. a cell wall component; FRAC group NC such as paraffinic oil; a compound selected from N-2 such as abamectin; and another compound that can influence enzymes and / or proteins in a pest cell such as beta- 1,3(4)-glucanase, chitosan, sodium hydrogen carbonate, lecithin, acetic acid, potassium hydrogen bicarbonate,or any combination thereof. Further agents A composition of the invention may further comprise at least one antifoaming agent, at least one thickening agent and / or rheology modifier, at least one antioxidant, or any combination thereof. A composition of the invention may further comprise at least one anti-freeze agent, at least one sticker, at least one biocide as preservative, at least one stabilizing agent, glycerol, and / or any combination thereof. In embodiments, an antifoaming agent may be selected from polymethylsiloxane, simethicone octanol, silicone oils and any combination thereof. A composition of the invention may also comprise two or more different anti-foam forming agents. An antifoaming agent may be present in an amount of between 0 (meaning absence of antifoaming agent) to up to 10 % (w / v), more preferred between 0.02 to up to 5 % (w / v), more preferred between 0.1 to up to 1 % (w / v), more preferred about 0.05 % (w / v) in a ready to use product for application to an agricultural crop, a plant or plant part, and / or a soil. In embodiments, a thickening agent and / or rheology modifier may be selected from agar, alginic acid, alginate, carrageenan, gellan gum, xanthan gum, succinoglycan gum, guar gum, acetylated distarch adipate, acetylated oxidised starch, arabinogalactan, ethyl cellulose, methyl cellulose, locust bean gum, starch sodium octenylsuccinate, optigel wx, bentonite, kaolin, attagite, pungite, triethyl citrate, other silicate based thickeners and any combination thereof. A rheology modifier is a natural polymer, a synthetic polymer or an inorganic material. Said rheology modifier is selected from an organically modified clay, a cellulose derivative, such as carboxymethyl, ethyl and hydroxyethyl, an animal fat derivative, a castor oil derivative, a metal oxide, a gum based rheology modifier and any combination thereof. A composition of the invention may also comprise two or more different thickening agents and / or rheology modifiers. A thickening agent and / or rheology modifier may be present in an amount of between 0 (meaning absence of thickening agent) to up to 10% (w / v), more preferred between 0.01 to up to 5 % (w / v), more preferred between 0.02 to up to 1 % (w / v), more preferred about 0.05 % (w / v) in a ready to use product for application to an agricultural crop, a plant or plant part, and / or a soil. In embodiments, an antioxidant may be selected from amino acids (e.g. glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazole (e.g. urocanic acid) and derivatives, vitamin C and derivatives (such as ascorbylpalmitate and ascorbyltetraisopalmitate, Mg-ascorbylphosphate, Na- ascorbylphosphate, ascorbyl-acetate), tocopherol and derivates (such as vitamin-E- acetate), mixtures of vitamin E, vitamin A and derivatives (vitamin-A-palmitate and -acetate) as well as coniferyl benzoate, rutinic acid and derivatives, ^- glycosylrutin, ferulic acid, furfurylideneglucitol, carnosine, butylhydroxytoluene, butylhydroxyanisole, trihydroxybutyrophenone and any combination thereof. A composition of the invention may also comprise two or more different antioxidants. An anti-oxidant is preferably present in an amount between 0 to of up to 20% (w / v), more preferred between 0.1 to up to 10 % (w / v), more preferred between 1 to up to 5 % (w / v), more preferred about 3 % (w / v) in a ready to use product for application to an agricultural crop, a plant or plant part, and / or a soil. In embodiments, an anti-freeze agent is selected from a polyethylene glycol (PEG), such as PEG200, PEG 350, PEG400, PEG500, PEG1000, PEG2000, PEG4000, tetramethylol methane, mannitol, diethylene glycol and any combination thereof. An anti-freeze agent may be present in an amount of between 0 (meaning absence of an anti-freeze agent) to up to 10% (w / v), more preferred between 0.01 to up to 5 % (w / v), more preferred between 0.02 to up to 1 % (w / v), more preferred about 0.05 % (w / v) in a ready to use product for application to an agricultural crop, a plant or plant part, and / or a soil. In embodiments, a composition of the invention may further comprise a sticker. Said sticker may be selected from an organosilicon / latex, a terpene based polymer and a combination thereof. A sticker may be present in an amount of between 0 (meaning absence of a sticker) to up to 10% (w / v), more preferred between 0.01 to up to 5 % (w / v), more preferred between 0.02 to up to 1 % (w / v), more preferred about 0.05 % (w / v) in a ready to use product for application to an agricultural crop, a plant or plant part, and / or a soil. In embodiments, a composition of the invention may further comprise a biocide as a preservative. A biocide as preservative may be present in an amount of between 0 (meaning absence of a biocide) to up to 10% (w / v), more preferred between 0.01 to up to 5 % (w / v), more preferred between 0.02 to up to 1 % (w / v), more preferred about 0.05 % (w / v) in a ready to use product for application to an agricultural crop, a plant or plant part, and / or a soil. Said biocide as preservative may be present in a concentration of between 0.001 and 20 g / L, more preferred between 0.005 and 5 g / L, more preferred between 0.01 and 1 g / L. Preferred biocides as preservative are weak acid preservatives such as lactic acid, benzoic acid, propionic acid, citric acid and acetic acid, the alkali metal or alkali earth metal salt of the weak acids, ethyl parabenzoate, borax, calcium bisulfite, calcium disodium EDTA, dehydroacetic acid, and isothiazoles, for example 5-Chloro-2- methyl-4- isothiazolin-3-one (KATHON™, Rohm and Haas), and quaternary ammonium salts such as, for example, l-(3-chloroallyl)-3,5,7-triaza-l- azoniaadamantane chloride (CTAC). A preferred biocide as preservative is a quaternary ammonium salt is provided by CTAC, which is stabilized with sodium bicarbonate (Dowicil®75). A composition of the invention may also comprise two or more different biocides as preservatives. A further preferred biocide as preservative is Kathon™, which is preferably present in a concentration of about 0,04 g / L. In embodiments, a stabilizing agent is selected from a pectin, a glycol, a tall oil compound, a hydrocolloid and any combination thereof. A stabilizing agent may be present in an amount of between 0 (meaning absence of a stabilizing agent) to up to 10% (w / v), more preferred between 0.01 to up to 5 % (w / v), more preferred between 0.02 to up to 1 % (w / v), more preferred about 0.05 % (w / v) in a ready to use product for application to an agricultural crop, a plant or plant part, and / or a soil. In embodiments, glycerol may be present in an amount of between 0 (meaning absence of glycerol) to up to 10% (w / v), more preferred between 0.01 to up to 5 % (w / v), more preferred between 0.02 to up to 1 % (w / v), more preferred about 0.05 % (w / v) in a ready to use product for application to an agricultural crop, a plant or plant part, and / or a soil. In embodiments, a composition of the invention is a suspension concentrate (SC), a water dispersible granule (WG), a wettable powder (WP), a suspo emulsion (oily) (SE), oil dispersion (OD), a dispersion concentrate (DC), a dry powder treatment composition, a water slurriable powder (WS), a flowable treatment composition, a flowable concentrate (FS), a water dispersible granule treatment composition, a suspo emulsion (SE) or a soluble liquid (SL). Methods of use The invention further provides a method for protecting a plant and / or plant part and / or soil against a pest such as a pathogenic fungus, an oomycete, a mite, a nematode and / or an insect, the method comprising providing sulfur and a 2ndactive ingredient (ai), in a ratio of 1000:1 – 1:100 (w / w; sulfur: 2ndai), preferably 750:1 - 1:50 (w / w; sulfur: 2ndai) to said plant and / or plant part and / soil such that the plant and / or plant part and / or soil is contacted with a sufficient amount of said sulfur and 2ndai, wherein the 2ndai is selected from clove oil, zoxamide, pydiflumetofen, metalaxyl-M, folpet, propamocarb, fluopyram, mandipropamid, fluopicolide, dithianon, dicloran, benthiavalicarb isopropyl, bixafen, thifluzamide, isopyrazam, adepidyn, mefentrifluconazole, metconazole, copper oxychloride, an enzyme such as beta-glucanase preferably beta-1,3(4)-glucanase, pyrimethanil, boscalid, abamectin, dodine, chitosan, copper sulfate, chitosan hydrochloride, COS-OGA, onion extract, nettle extract, mustard extract, horsetail extract, silicic acid, willow extract, swinglea glutinosa extract, fructose, sucrose, sodium hydrogen carbonate, calcium hydroxide, magnesium hydroxide, sunflower oil, maize oil, soyabean oil, onion oil, lecithin, neem oil, activated charcoal, bentonite, thymol, carvacrol, eugenol, geraniol, limonene, acetic acid, natamycin, potassium hydrogen bicarbonate, paraffinic oil, aluminium sulfate, fatty acid, garlic extract, a phosphonate or a salt thereof, laminarine and a microorganism, including an extract of a microorganism, selected from a Trichoderma species, a yeast-based substance, a Bacillus species such as B. amyloliquefaciens, a Rhizobium species and any combination thereof. In embodiments, a method of the invention comprises providing a composition of the invention to said plant and / or plant part and / or soil such that the plant and / or plant part and / or soil is contacted with a sufficient amount of said sulfur and the 2ndai. The invention further provides a method for treating a plant and / or plant part and / or soil affected by a pest such as a fungus, an oomycete, a nematode, a mite and / or an insect, the method comprising providing sulfur and a 2ndactive ingredient (ai), in a ratio of 1000:1 – 1:100 (w / w; sulfur: 2ndai), preferably 750:1 - 1:50 (w / w; sulfur: 2ndai) to said plant and / or plant part and / or soil such that the plant and / or plant part and / or soil is contacted with a sufficient amount of said sulfur and 2ndai, wherein the 2ndai is selected from clove oil, zoxamide, pydiflumetofen, metalaxyl-M, folpet, propamocarb, fluopyram, mandipropamid, fluopicolide, dithianon, dicloran, benthiavalicarb isopropyl, bixafen, thifluzamide, isopyrazam, adepidyn, mefentrifluconazole, metconazole, copper oxychloride, an enzyme such as beta-glucanase preferably beta-1,3(4)-glucanase, pyrimethanil, boscalid, abamectin, dodine, chitosan, copper sulfate, chitosan hydrochloride, COS- OGA, onion extract, nettle extract, mustard extract, horsetail extract, silicic acid, willow extract, swinglea glutinosa extract, fructose, sucrose, sodium hydrogen carbonate, calcium hydroxide, magnesium hydroxide, sunflower oil, maize oil, soyabean oil, onion oil, lecithin, neem oil, activated charcoal, bentonite, thymol, carvacrol, eugenol, geraniol, limonene, acetic acid, natamycin, potassium hydrogen bicarbonate, paraffinic oil, aluminium sulfate, fatty acid, garlic extract, a phosphonate or a salt thereof, laminarine and a microorganism, including an extract of a microorganism, selected from a Trichoderma species, a yeast-based substance, a Bacillus species such as B. amyloliquefaciens, a Rhizobium species and any combination thereof. In embodiments, a method of the invention comprises providing a composition of the invention to said plant and / or plant part and / or soil such that the plant and / or plant part and / or is contacted with a sufficient amount of said sulfur and the 2ndai. In embodiments, said method is for protecting the plant or plant part and / or soil from a pest and / or for treating a plant and / or plant part and / or soil that is affected by a pest, wherein the pest is selected from an insect, such as aphid species and beetle species, a nematode such as Meloidogyne incognita, Rotylenchulus reniformis and Meloidogyne floridensis, a fungus, including ascomycetes species such as Botrytis cinerea, Fusarium graminearum, and powdery mildew causing pest, basidiomycete species such as Rhizoctonia solani, a oomycete species, such as Pythium ultimum and Phytophthora infestans, downy mildew causing pest and any combination thereof. In embodiments, the 2ndai is carvacrol, thymol, a yeast-based substance, acetic acid, clove oil and / or geraniol and the pest is a fungus. In said embodiments, the ratio of sulfur and 2ndai preferably is a ratio of 100:1 – 1:10 (w / w; sulfur: 2ndai), more preferably a ratio of 50:1 – 1:1 (w / w; sulfur: 2ndai). In embodiments, the 2ndai is carvacrol and / or thymol and the pest is Botrytis cinerea. In said embodiments, the ratio of sulfur and 2ndai preferably is a ratio of 20:1 – 1:1 (w / w; sulfur: 2ndai), more preferably a ratio of 10:1 – 5:1 (w / w; sulfur: 2ndai). In embodiments, the 2ndai is a yeast-based substance and the pest is powdery mildew causing pest. In said embodiments, the ratio of sulfur and 2ndai preferably is a ratio of 10:1 – 1:1 (w / w; sulfur: 2ndai), more preferably a ratio of 6:1 – 2:1 (w / w; sulfur: 2ndai). In embodiments, the 2ndai is acetic acid and / or clove oil, and the pest is Fusarium graminarum. In said embodiments, the ratio of sulfur and 2ndai preferably is a ratio of 50:1 – 1:1 (w / w; sulfur: 2ndai), more preferably a ratio of 20:1 – 2.5:1 (w / w; sulfur: 2ndai). In embodiments, the 2ndai is geraniol and the pest is Rhizoctonia solani. In said embodiments, the ratio of sulfur and 2ndai preferably is a ratio of 100:1 – 1:10 (w / w; sulfur: 2ndai), more preferably a ratio of 50:1 – 1:1 (w / w; sulfur: 2ndai) . In embodiments, the 2ndai is a beta-glucanase and the pest is a nematode, preferably Meloidogyne incognita. In said embodiments, the ratio of sulfur and 2ndai preferably is a ratio of 50:1 – 10:1 (w / w; sulfur: 2ndai), more preferably a ratio of 25:1 – 15:1 such as 22.4:1 (w / w; sulfur: 2ndai). In embodiments, the 2ndai is zoxamide, copper oxychloride, fluopyram, dicloran, mefentrifluconazole, Swinglea glutinosa extract, yeast based substance, pyrimethanil, boscalid, abamectin, pydiflumetofen, metalaxyl-M, propamocarb, clove oil, horsetail extract, sodium hydrogen carbonate, sunflower oil, maize oil, soyabean oil, lecithin, neem oil, limonene, copper sulfate, natamycin, potassium hydrogen bicarbonate, paraffinic oil, garlic extract, chitosan and / or a Bacillus species, such as Bacillus amyloliquefaciens, and the pest is an oomycete. In said embodiments, the ratio of sulfur and 2ndai preferably is a ratio of 1000:1 – 1:20 (w / w; sulfur: 2ndai), more preferably a ratio of 500:1 – 1:10 (w / w; sulfur: 2ndai). In embodiments, the 2ndai is zoxamide, copper oxychloride, fluopyram, dicloran, mefentrifluconazole, Swinglea glutinosa extract, yeast based substance, pyrimethanil, boscalid, abamectin, pydiflumetofen, metalaxyl-M, propamocarb, clove oil, horsetail extract, maize oil, soyabean oil, neem oil, limonene, copper sulfate, natamycin, potassium hydrogen bicarbonate, paraffinic oil, garlic extract, chitosan and / or a Bacillus species such as preferably Bacillus amyloliquefaciens, and the pest is Pythium ultimum. In said embodiments, the ratio of sulfur and 2ndai preferably is a ratio of 1000:1 – 1:20 (w / w; sulfur: 2ndai), more preferably a ratio of 500:1 – 1:10 (w / w; sulfur: 2ndai). In embodiments, the 2ndai is sodium hydrogen carbonate, sunflower oil, lecithin and / or chitosan, and the pest is Phytophthora infestans. In said embodiments, the ratio of sulfur and 2ndai preferably is a ratio of 100:1 – 1:10, 10:1 – 1:5, preferably 5:1 – 1:1 (w / w; sulfur: 2ndai), more preferably a ratio of 3:1 – 2.5:1 (w / w; sulfur: 2ndai). In embodiments, the 2ndai is clove oil, and the pest is an aphid. In said embodiments, the ratio of sulfur and 2ndai preferably is a ratio of 1000:1 – 1:20 (w / w; sulfur: 2ndai), more preferably a ratio of 100:1 – 1:10, more preferably a ratio of 20:1-1:10 (w / w; sulfur: 2ndai) In embodiments, said plant part preferably is a leaf, stem, seed, bulb, flower bulb, seed-potato, root, tuber, fruit and / or vegetable, most preferably a seed, root, bulb, leaf, fruit or vegetable. The invention further provides a method for improving the development and / or yield of a plant, comprising providing sulfur and a 2ndactive ingredient (ai), in a ratio of 1000:1 – 1:100 (w / w; sulfur: 2ndai), preferably 750:1 - 1:50 (w / w; sulfur: 2ndai), and contacting the plant with said sulfur and the 2ndai. Sulfur and a 2ndactive ingredient (ai), in a ratio of 1000:1 – 1:100 (w / w; sulfur: 2ndai), preferably 750:1 - 1:50 (w / w; sulfur: 2ndai), can be applied in many different ways. For example, said sulfur and 2ndai) can be applied by: (1) spraying plants in the field or in greenhouses optionally using a carrier such as a wax or an oil; (2) dipping roots, bulbs or seed-potatoes; (3) adding to a plant part or root system e.g., via the soil; (4) adding to the soil; (5) adding to water or watering systems applied in e.g., greenhouses or in the field; (6) treating harvested plant parts such as bulbs, seeds, leaves, cereals, soybeans, flowers, fruit, vegetables or plants by e.g., dipping, coating or spraying. In embodiments, the sulfur and 2ndai, can be applied sequentially to the plant, plant part, or soil. For this, the sulfur or 2ndai, may be applied first to a plant, plant part, or soil, followed by the remaining of the sulfur or 2ndai. In embodiments, said remaining of the sulfur or 2ndai or salt thereof may be applied after 2 days, 4 days, 6 days, 7 days, 8 days, 10 days, 12 days, 14 days, 16 days, 18 days and / or 20 days after applying the first sulfur or 2ndai. In these embodiments, the sulfur and 2ndai are to be applied as separate compositions. Said separate compositions may comprise one or more further active ingredients. In embodiments, sulfur may be applied first to a plant, plant part, or soil, followed by the 2ndai. Care should be taken to apply the 2ndai in such an amount that the ratio of sulfur to 2ndai is 1000:1 – 1:100 (w / w; sulfur: 2nd ai), preferably750:1 - 1:50 (w / w; sulfur: 2nd ai). In embodiments, the 2ndai may be applied first to a plant, plant part, or soil, followed by the sulfur. Care should be taken to apply the sulfur in such an amount that the ratio of sulfur to 2ndai is 1000:1 – 1:100 (w / w; sulfur: 2nd ai), preferably 750:1 - 1:50 (w / w; sulfur: 2nd ai). A preferred method for improving the development and / or yield of a plant, comprises providing a composition according to the invention, and contacting the plant with said composition. A composition of the invention can be applied without diluting or after dilution. Usually a composition of the invention will be applied via an aqueous or oil dilution, via a dressing, coating or a wax. A composition according to the invention is preferably undiluted or diluted. A composition according to the invention is preferably diluted 10 - 106times, preferably 10 - 1000 times, in an aqueous solution or in oil, for application in a method of the invention. It is easy to understand that the required amount of the composition of the invention will differ per application as different applications may require different treatments. In general, however, the amount of composition in a ready-to-use final composition such as e.g. a dipping or spraying suspension, calculated back to the amount of sulfur in the composition required to treat the product (e.g., a soil, a seed, a bulb, a plant in the field or a harvested fruit) will be 0.01 - 150 g of sulfur per liter, such as 5 - 50 g / L, preferably less than 20 g / L, more preferred less than 15 g / L, more preferred less than 10 gram / L of sulfur, such as 0.1, 0.5, 1, 2, 3, 4, 5, 6, 7, 8 or 9 grams of sulfur / L. The final amount of sulfur in a soil or growth medium, on a plant or on a harvested plant part can be expressed in different ways. As an example, the final amount of sulfur on a seed applied, for example, via a seed dressing or a seed coating is 0.01 to 20.0 grams of sulfur per kg of seed, such as 0.05 - 5.0 grams of sulfur per kg of seed, or even 0.1 - 2.0 grams of sulfur per kg of seed. As an example, a composition of the invention for immersion or spraying of products such as roots, flower bulbs, seed-potatoes, onions, apples, pears, bananas and pineapples will generally comprise 0.01 g / L to 100 g / L, preferably 0.03 g / L to 50 g / L and most preferably 0.05 g / L to 5 g / L of sulfur. After treatment of products such as leaves, flower bulbs, seed-potatoes, seed, onions, apples, pears, bananas and pineapples, typically the amount of sulfur on the product is 0.01 - 20.0 mg / dm2; preferably 0.1 - 10.0 mg / dm2. In case of treatment of a soil such as mushroom growth substrate, each spray treatment will add 0.01 - 5.0 grams of sulfur per m2of growth substrate, more preferably 0.02 -1.0 grams of sulfur per m2of growth substrate. In case of treatment of a soil in which, for example, raw crops, vegetables or ornamental plants are grown, 0.01-5.0 grams of sulfur may be applied per m2which is preferably mixed in the top layer of the soil, more preferably 0.1 - 1.0 grams of sulfur per m2. In case of a spray application on a crop in the field a typical dosage is 1 - 5000 grams of sulfur per hectare, more preferably 50 - 2000 grams per hectare. However, for a crop such as bananas, the preferred dosage of sulfur may be reduced, such as 5 -500 grams of sulfur per hectare, more preferably 10 -100 grams per hectare. Sulfur and a 2ndactive ingredient (ai), in a ratio of 1000:1 – 1:100 (w / w; sulfur: 2ndai), preferably 750:1 - 1:50 (w / w; sulfur: 2ndai), preferably a composition of the invention, can be added at any suitable time using any suitable method to the growth medium, soil, plant or plant part; e.g., before, during or after planting of e.g. bulb, seed-potato, seed, a cutting or a young plant; during growth in the field, after harvesting or during storage of a seed, fruit, vegetable, nut or flower bulb. An aspect of the invention provides a use of sulfur for increasing the biological activity of a 2ndai. Said use according to the invention may result in a reduced rate of application of 2ndai and / or an increase of the biological activity of said 2ndai. An aspect of the invention provides the application of sulfur for increasing biological activity of a 2ndai that is present in or on a plant, plant part, or soil, whereby sulfur may increase the biological activity of said 2ndai. The terms “reduced rate of application” and “increasing biological activity” may refer to a rate of application that is more than 5%, preferably more than 10%, preferably more than 30%, reduced, when compared to the rate of application of the 2ndai without sulfur, or increased, when compared to the biological activity of the 2ndai without sulfur. A composition of the invention is suitable for the control of pests that are encountered in horticulture, agriculture, and forestry, including ascomycetes, basidiomycetes and / or oomycetes, insects and nematodes. The composition may be active against normally sensitive and normally resistant pest species. The composition may be active during all or individual stages of development. Prior to use, a composition comprising an antifungal composition according to the invention may be dissolved or dispersed in water, or diluted with water, to provide an aqueous composition comprising 0,001 - 10 w / v% of sulfur. If required, an agriculturally acceptable carrier such as a sticking agent may be added to the diluted aqueous composition. A composition according to the invention is preferably diluted 2-5000 times, preferably about 200 times, with an aqueous solvent, preferably water, to contain 0.0001 - 10 % (w / v) of sulfur, prior to contacting a plant, plant part or soil with the composition. To control agricultural pests, the invention provides a use of sulfur and a 2ndactive ingredient (ai), in a ratio of 1000:1 – 1:100 (w / w; sulfur: 2ndai), preferably 750:1 - 1:50 (w / w; sulfur: 2ndai) for the protection of a plant, or a part of a plant, against a pest. In order to achieve this effect, said plant, plant part, or soil is contacted with said sulfur and 2ndai, preferably with a composition of the invention, including a diluted aqueous composition as described herein above. Said sulfur and 2ndai, in a ratio of 1000:1 – 1:100 (w / w; sulfur: 2ndai), preferably 750:1 - 1:50 (w / w; sulfur: 2ndai) may be used, for example, to control powdery mildew and Botrytis infections on food / feed crops, including tree fruits, vegetable crops, field crops, grapes, ornamental plants, and sod farms. Further use, for example, is to control scab, including common scab, apple scab and black scab on potatoes, pear scab, and powdery scab, brown rot of peaches, currant and gooseberry leaf spot, Fusarium diseases, peanut leafspot, and mildew on roses. Further use, for example, is to oomycetes-mediated diseases such as damping off and root rot (Pythium ultimum), downy mildew and potato late blight (Phytophthora infestans). Other uses include protection against diseases caused by Sclerotinia and Colletotrichum species. Other uses include protection of flowers and ornamentals, home vegetable gardens and residential turf. Other uses include protection against nematodes, aphids or thrips. In addition, said sulfur and 2ndai, preferably a composition of the invention, including a diluted aqueous composition, may be contacted with isolated seeds, fruits, nuts, vegetables, and / or flowers. The invention further provides a method of protecting a plant and / or plant part and / or soil against a pest and / or treating a plant and / or plant part and / or soil affected by a pest, comprising contacting said plant or said plant part with sulfur and a 2ndai, preferably with a diluted aqueous composition according to this invention. The invention further provides a method of preventing, reducing and / or eliminating the presence of a pest on a plant, or a part of a plant, comprising contacting said plant, or part of said plant, with sulfur and a 2ndai, preferably with an aqueous composition according to this invention. For said use and said methods, the sulfur and 2ndai, preferably said composition, including a diluted aqueous composition, is preferably sprayed over a plant, and / or part thereof and / or soil. Spraying applications, including the use of automatic spraying systems, are known to reduce labor costs and are cost-effective. Methods and equipment well-known to a person skilled in the art can be used for that purpose. The sulfur and 2ndai, preferably a composition of the invention, including a diluted aqueous composition, can regularly be sprayed over the plant and / or plant part and / or soil, when the risk of infection is high. When the risk of infection is lower, spray intervals may be longer, as is known to a person skilled in the art. As is indicated herein above, sulfur and 2ndai may be separately sprayed over a plant, and / or part thereof and / or soil. In embodiments, sulfur may firstly be sprayed over a plant, and / or part thereof and / or soil, as it remains active for a longer period of time after spraying over a plant, or part thereof, when compared in general to a 2ndai. For example, sulfur may be sprayed between 1 day and 2 months before the 2ndai is sprayed over the plant and / or plant part and / or soil. In embodiments, the time period between the two applications may be between 2 days and 1 month, between 4 days and 3 weeks, between 7 days and 2 weeks, such as about 10 days. As will be understood by a person skilled in the art, a first round of spraying may include the sulfur and part of the 2ndai, while the remainder of the 2ndai is included in a second round of spraying, and even in a second and a third round of spraying. Other methods suitable for contacting plants and / or parts thereof with sulfur and 2ndai, preferably with a composition of the invention are also a part of the present invention. These include, but are not limited to, dipping, watering, drenching, introduction into a dump tank, vaporizing, atomizing, fogging, fumigating, painting, brushing, misting, dusting, foaming, spreading-on, packaging and coating (e.g. by means of wax or electrostatically). In addition, sulfur and 2ndai, preferably a composition of the invention, including a diluted aqueous composition, may be injected into the soil. For example, a plant or a part of a plant thereof may be coated with sulfur and 2ndai, preferably with a diluted aqueous composition comprising sulfur and 2ndai according to the invention by submerging the plant or part thereof in a composition comprising sulfur and 2ndai, preferably in a diluted aqueous composition according to the invention, to protect the plant of part thereof against a pest and / or to prevent, reduce and / or eliminate the presence of a pest on a plant, or a part of a plant. In embodiments, a plant or a part of a plant that is treated with sulfur and 2ndai, preferably with a composition according to the invention, or with a dilution thereof, is a fruit, preferably a post-harvest fruit such as, for example, a citrus fruit such as orange, mandarin and lime, a pome fruit such as apple and pear, a stone fruit such as almond, apricot, cherry, damson, nectarine, tomato, watermelon, a tropical fruit such as banana, mango, lychee and tangerine. A preferred fruit is a citrus fruit, such as orange and / or a tropical fruit such as banana. In embodiments, a plant or a part of a plant that is treated with sulfur and 2ndai, preferably with a composition according to the invention, or with a dilution thereof, is a vegetable. Said vegetable preferably is selected from lettuce, tomato, pepper, especially sweet pepper, eggplant, and brassica vegetables such as mustard, kale, cabbage, collard greens, broccoli, cauliflower, gai lan, Brussels sprouts, and kohlrabi. Said vegetable may be a row crop, such as sunflower, potato, canola, dry bean, field pea, flax, safflower, sugar beets, soybeans, cotton, or a cereal, such as wheat, buckwheat, rye, barley, and maize. In embodiments, a part of a plant that is treated with sulfur and 2ndai, preferably with a composition according to the invention, or with a dilution thereof, is a seed or leaf. Said seed or leaf may, for example, be selected from wheat, corn, soybean, sugar beet, tomato, potato, eggplant, pepper, cucumber, pumpkin, loofah, melon, broccoli, cauliflower, cabbage, choy sum, and rutabaga. In embodiments, a plant that is treated with sulfur and 2nd ai, preferably with a composition according to the invention, or with a dilution thereof, is a row crop, such as sunflower, potato, canola, dry bean, field pea, flax, safflower, buckwheat, cotton, maize, soybeans, and sugar beets. The invention further provides a method of controlling diseases caused by phytopathogenic fungi or oomycete in plants or on propagation material thereof, which method comprises contacting the plants, or propagation material thereof, with sulfur and 2ndai, preferably with a composition according to the invention, including an aqueous diluted composition. The present invention also provides a method of controlling pests comprising contacting (i) a pest or a locus thereof, (ii) a plant or a locus or propagation material thereof, (iii) soil, and / or (iv) an area in which a pest infestation is to be prevented with sulfur and 2ndai, preferably with a composition of the invention. The present invention also provides a method for improving pest control comprising applying sulfur and 2ndai, preferably a composition of the invention to a plant / or soil. The present invention also provides a method for prolonging a controlling effect of a 2ndai on a plant, plant part of soil, comprising applying sulfur and said 2ndai, preferably a composition of the invention or dilution thereof, to the plant, plant part or soil. In some embodiments, the target is a plant, plant part, or soil. In some embodiments, the target is a fungus or oomycete. The present invention also provides a method for pest control by preventive, curative or persistence treatment of a plant disease caused by phytopathogenic fungi or oomycetes comprising contacting a plant, a locus thereof or propagation material thereof with an effective amount of sulfur and 2ndai, preferably with a composition according to the invention. The described compositions comprising sulfur and 2ndai according to the invention may be applied to healthy or diseased plants. The described compositions can be used on various plants including but not limited to crops, seeds, bulbs, propagation material, or ornamental species. The present invention provides a method of controlling a disease caused by phytopathogenic fungi or oomycetes on plants or propagation material thereof, comprising contacting the plants, the locus thereof or propagation material thereof with sulfur and a 2ndai, preferably with a composition according to the invention. In embodiments, sulfur and 2ndai, such as a composition according to the invention, are applied at a rate effective for controlling a pest. In embodiments, sulfur and a 2ndai, such as a composition according to the invention, are applied at a rate effective for preventing infestation of the pest. In embodiments, sulfur and a 2ndai, such as a composition according to the invention, are applied at a rate effective for curing infestation of the pest. In embodiments, a method of the invention is effective for preventing infestation of a pest. In embodiments, the method is effective for curing infestation of the pest. In embodiments, the method is effective for increasing the pesticidal activity of a 2ndai. In embodiments, the method is effective for prolonging the pesticidal effect of a 2ndai. In embodiments, a method of the invention is effective for decreasing the half maximal effective concentration (EC50) of a 2ndai. In embodiments, the method is effective for decreasing the EC50 by at least 10%. In embodiments, the method is effective for decreasing the EC50 by at least 25%. In embodiments, the method is effective for decreasing the EC50 by at least 35%. In embodiments, the method is effective for decreasing the EC50 by at least 50%. In embodiments, a method of the invention is effective for decreasing the LC50 of a 2ndai. In embodiments, the method is effective for decreasing the LC50 by at least 10%. In embodiments, the method is effective for decreasing the LC50 by at least 25%. In embodiments, the method is effective for decreasing the LC50 by at least 50%. In embodiments, the method is effective for decreasing the LC50 by at least 75%. In embodiments, the method is effective for decreasing the LC50 by at least 90%. In embodiments, a method of the invention is effective for decreasing the LC90 of a 2ndai. In embodiments, the method is effective for decreasing the LC90 by at least 10%. In embodiments, the method is effective for decreasing the LC90 by at least 25%. In embodiments, the method is effective for decreasing the LC90 by at least 50%. In embodiments, the method is effective for decreasing the LC90 by at least 75%. In embodiments, the method is effective for decreasing the LC90 by at least 90%. In embodiments, a method of the invention further comprises applying at least one additional agrochemical to a pest, a plant part, a plant, the locus, or propagation material thereof. Said additional agrochemical may be present in a composition according to the invention. Said agrochemical may be a fungicide, insecticide, nematicide, acaricide, molluscicide and / or any combination thereof. Said additional agrochemical may be admixed in a tank, or applied sequentially with sulfur and 2ndai, preferably with a composition according to the invention, to the plants, plant parts, or soil. In embodiments wherein the additional agrochemical is applied sequentially with sulfur and 2ndai, the sulfur, 2ndai or additional agrochemical, may be applied first to a plant, plant part, or soil, followed by one of the remaining of the sulfur, 2ndai or additional agrochemical, followed thereafter by the final remaining of the sulfur, 2ndai or additional agrochemical. In embodiments, said one of the remaining of the sulfur, 2ndai or additional agrochemical and final remaining of the sulfur, 2ndai or additional agrochemical, may be applied after 2 days, 4 days, 6 days, 7 days, 8 days, 10 days, 12 days, 14 days, 16 days, 18 days and / or 20 days after applying the first sulfur, 2ndai or additional agrochemical. In these embodiments, the sulfur, 2ndai and additional agrochemical are to be applied as separate compositions. Said separate compositions may comprise one or more further active ingredients. Illustrative numbered Embodiments Various embodiments of the invention are hereinafter highlighted in a set of numbered embodiments. These embodiments are not to be interpreted as being limiting on the invention or the inventive concept. P1. A composition comprising sulfur and a 2ndactive ingredient (ai), in a ratio of between 1000:1 – 1:100 (w / w; sulfur: 2ndai), preferably between 750:1 and 1:50 (w / w; sulfur: 2ndai) and, optionally, one or more surfactants. P2. The composition of Embodiment P1, wherein the 2ndai is a fungicide, insecticide or nematicide. P3. The composition of Embodiment P1 or Embodiment P2, wherein the 2ndai is selected from a chemical compound, including a natural compound, and a microorganism. P4. The composition of any one of Embodiments P1-3, wherein the 2ndai is a chemical compound selected from pyrimethanil, boscalid, abamectin, pydiflumetofen, metalaxyl-M, folpet, propamocarb, mandipropamid, fluopicolide, dithianon, fluopyram, benthiavalicarb isopropyl, dodine, fluopyram, bixafen, thifluzamide, isopyrazam, adepidyn, metconazole and any combination thereof. P5. The composition of any one of c Embodiments P1-3, wherein the 2ndai is a natural compound selected from an enzyme such as beta-glucanase, chitosan, chitosan hydrochloride, COS-OGA, clove oil, onion extract, nettle extract, mustard extract, horse tail extract, silicic acid, willow extract, fructose, sucrose, sodium hydrogen carbonate, calcium hydroxide, magnesium hydroxide, sunflower oil, maize oil, soyabean oil, onion oil, lecithin, neem oil, activated charcoal, bentonite, thymol, carvacrol, eugenol, geraniol, limonene, acetic acid, copper sulfate, natamycin, potassium hydrogen bicarbonate, paraffinic oil, aluminium sulfate, fatty acid, garlic extract, a phosphonate or a salt thereof, laminarine and any combination thereof. P6. The composition of any one of Embodiments P1-3, wherein the 2ndai is a microorganism, including an extract of a microorganism, selected from a Trichoderma species, a yeast-based substance, a Bacillus species, a Rhizobium species such as R. leguminosarum and any combination thereof. P7. The composition of any one of Embodiments P1-3 or P6, wherein the 2ndai is a microorganism selected from Trichoderma asperellum, T. harzianum, T. atroviride and any combination thereof. P8. The composition of any one of Embodiments P1-3 or P6, wherein the 2ndai is a microorganism selected from Bacillus thuringiensis, B. amyloliquefaciens, B. thuringiensis, B. subtilis, B. pulilus and any combination thereof. P9. The composition of any one of Embodiments P1-8, further comprising at least one antifoaming agent, at least one thickening agent and / or rheology agent, at least one stabilizing agent, glycerol, or any combination thereof. P10. A method for protecting a plant or plant part against a pest, comprising (a) providing sulfur and a 2ndactive ingredient (ai), in a ratio of between 1000:1 – 1:100 (w / w; sulfur: 2ndai), preferably between 750:1 and 1:50 (w / w; sulfur: 2ndai); (b) applying the sulfur and 2ndai to said plant or plant part. P11. The method of Embodiment P10, wherein said plant part is a seed, bulb, root, leaf, flower, fruit or vegetable. P12. A method for protecting a soil, the method comprising (a) providing sulfur and a 2ndactive ingredient (ai) in a ratio of between 1000:1 – 1:100 (w / w; sulfur: 2ndai), preferably between 750:1 and 1:50 (w / w; sulfur: 2ndai), and (b) applying the sulfur and 2ndai to the soil. P13. The method according to any one of Embodiments P10-12, whereby said sulfur and 2ndactive ingredient (ai) are provided sequentially to the plant, plant part, or soil. P14. The method according to any one of Embodiments P10-12, whereby said sulfur and 2ndai are provided by a composition of any one of Embodiments 1-9. P15. Use of sulfur for enhancing the activity of a 2ndai against insects, nematodes, fungi, including ascomycetes and basidiomycetes and / or oomycetes. The invention is illustrated by the following examples without limiting it thereby. EXAMPLES General: Determination of synergy In some instances, the stimulation of the pesticidal activity, such as the antifungal activity, of a second active ingredient (2ndai) by sulfur was found to be synergistic. The Colby equation (Colby, 1967. Weeds 15: 20–22) calculates the expected antifungal activity (E in %) of a combination comprising more than one active ingredients: wherein X and Y are the observed antifungal activities (in %) of the individual active ingredients x and y, respectively. If the observed antifungal activity (O in %) of the combination exceeds the expected antifungal activity (E in %) of the combination and the synergy factor O / E is thus > 1.0, the combined application of the active ingredients is indicative of a synergistic antifungal effect. The same equation is used for measuring other synergistic pesticidal effects for example nematicidal and / or insecticidal effects, as shown herein below. Example 1: Effect of sulfur on pyrimethanil efficacy on Pythium ultimum infection tested on petri dishes. In this experiment, the products Pyrus ® (UPL) and Cerasulfur® (Ceradis) containing the active ingredients pyrimethanil and sulfur, respectively, were tested. Materials and methods: Agar medium was prepared by mixing in a 100 ml Duran bottle 3,9 g of potato dextrose agar (PDA; Carl-Roth GmbH + Co. KG, Karlsruhe, Germany) with 100 ml deionized water and autoclaving the Duran bottle at 120 °C for 15 minutes. After autoclaving, the solution was cooled by putting it in a 50 °C oven for about two hours. Afterward the semi-liquid PDA solution was carefully mixed with sulfur and / or active ingredient as specified in Table 1 (left column). The medium in the Duran bottle was divided over 5 petri dishes (90 x 15mm), 20 ml per petri dish by using 25 ml serological pipets (ROTILABO®; Carl-Roth). Hereafter, a circular agar mycelium plug (circular segment with a height on 5 mm of agar, fully grown with fresh Pythium ultimum mycelium, which was cut out of a petri dish with the broad side of a yellow pipette tip (Greiner Bio-One, 200 µl tips) with a diameter of 5 mm, was placed in the center of the petri dish. Hereafter the petri dishes were placed in the incubator at 22 °C. Measurement of the fungal growth was done using caliper. Each sulfur and / or active ingredient treatment was performed in five fold. Synergistic calculation was done using the Colby equation. Results: Measurements were performed 1 day after placing the mycelium plug. Results are presented in Table 1. It is concluded that a combination of sulfur and pyrimethanil has a synergistic effect against the oomycete Pythium ultimum at ratios from 5:1 to 25:1 (w / w; sulfur:pyrimethanil). Table 1. Antifungal effect of sulfur (Cerasulfur®, Ceradis) in combination with pyrimethanil (Pyrus ®, UPL) against Pythium ultimum infection. Sulfur –2nd ai Avg infected Observed ExpectedO / E Interaction(ppm) area (mm2) % % 0- 0 937.9 0.0100 - 0 848.5 9.50 - 20 126.8 86.50 -10 329.1 64.90 - 4 730.5 22.1100 - 20 0.0 100.0 87.8 1.1 Synergism100 - 10 135.6 85.5 68.3 1.3 Synergism100 - 4 476.2 49.2 29.5 1.7 SynergismExample 2: Effect of sulfur on yeast-based substance efficacy on Pythium ultimum infection tested on petri dishes. In this experiment, the products Romeo® (Agrauxine Lesaffre) and Cerasulfur® (Ceradis) containing the active ingredients Cerevisane® yeast based substance, which comprises cell wall of the yeast Saccharomyces cerevisiae strain LAS117, and sulfur, respectively, were tested as described in Example 1. The amount of each compound and results are presented in Table 2. Measurements were performed 2 days after placing the mycelium plug. Results: It is concluded that a combination of sulfur and a yeast-based substance as 2nd ai has a synergistic effect against the oomycete Pythium ultimum at ratios from 1:1 to 75:1 (w / w; sulfur:Cerevisane®). Table 2. Antifungal effect of sulfur (Cerasulfur®, Ceradis) in combination with yeast based substance (Romeo®, Cerevisane®, Agrauxine Lesaffre) against Pythium ultimum infection. Sulfur – 2nd ai Avg infected Observed ExpectedO / E Interaction(ppm) area (mm2) % % 0- 0 3821.7 0.0100 - 0 3401.2 11.00 - 100 4267.0 -11.70 - 1.33 4201.7 -9.9100 - 100 3364.8 12.0 0.6 18.9 Synergism100 - 1.33 3080.8 19.4 2.2 9.0 SynergismExample 3: Effect of sulfur on boscalid efficacy on Pythium ultimum infection tested on petri dishes. In this experiment, the products Cantus® (BASF) and Cerasulfur® (Ceradis) containing the active ingredients boscalid and sulfur, respectively, were tested as described in Example 1. The amount of each compound and results are presented in Table 3. Measurements were performed 2 days after placing the mycelium plug. Results: It is concluded that a combination of sulfur and boscalid has a synergistic effect against the oomycete Pythium ultimum at ratios from 1:1 to 5:1 (w / w; sulfur:boscalid). Table 3. Antifungal effect of sulfur (Cerasulfur®, Ceradis) in combination with boscalid (Cantus®, BASF) against Pythium ultimum infection tested on petri dishes. Sulfur – 2nd ai Avg infected Observed ExpectedO / E Interaction(ppm) area (mm2) % % 0- 0 5148.5 0.050 - 0 4566.4 11.30 - 50 5287.1 -2.70 - 10 5130.8 0.350 - 50 3956.3 23.2 8.9 2.6 Synergism50 - 10 3568.2 30.7 11.6 2.6 Synergism Example 4: Effect of sulfur on abamectin efficacy on Pythium ultimum infection tested on petri dishes. In this experiment, the products Vertimec Gold® (Syngenta) and Cerasulfur® (Ceradis) containing the active ingredients abamectin and sulfur, respectively, were tested as described in Example 1. Measurements were performed 1 day after placing the mycelium plug. The amount of each compound and results are presented as specified in Table 4. Results: It is concluded that a combination of sulfur and abamectin has a synergistic effect against the oomycete Pythium ultimum at ratios from 10:1 to 100:1 (w / w; sulfur:abamectin). Table 4. Antifungal effect of sulfur (Cerasulfur®, Ceradis) in combination with abamectin (Vertimec Gold®, Syngenta) against Pythium ultimum infection tested on petri dishes. Sulfur – 2nd ai Avg infected Observed ExpectedO / E Interaction(ppm) area (mm2) % % 0- 0 1109.2 0.050 - 0 1003.7 9.50 - 5 818.1 26.20 - 0.5 994.1 10.450 - 5 557.7 49.7 33.3 1.5 Synergism50 - 0.5 830.3 25.1 18.9 1.3 SynergismExample 5: Effect of sulfur on chitosan efficacy on Pythium ultimum infection tested on petri dishes. In this experiment, the products Kitogreen® (KitoZyme, Herstal Belgium) and Cerasulfur® (Ceradis) containing the active ingredients chitosan and sulfur, respectively, were tested as described in Example 1. Measurements were performed 1 day after placing the mycelium plug. The amount of each compound and results are presented as specified in Table 5. Results: It is concluded that a combination of sulfur and chitosan has a synergistic effect against the oomycete Pythium ultimum at ratios from 10:1 to 100:1 (w / w; sulfur:chitosan). Table 5. Antifungal effect of sulfur (Cerasulfur®, Ceradis) in combination with chitosan (Kitogreen®) against Pythium ultimum infection tested on petri dishes. Sulfur – 2nd ai Avg infected Observed ExpectedO / E Interaction(ppm) area (mm2) % % 0- 0 553.7 0.050 - 0 485.4 12.30 - 5 483.1 12.70 - 0.5 551.2 0.450 - 5 409.1 26.1 23.5 1.1 Synergism50 - 0.5 469.2 15.3 12.7 1.2 SynergismExample 6: Effect of sulfur on pydiflumetofen efficacy on Pythium ultimum infection tested on petri dishes. In this experiment, the products Saltro® (Syngenta) and Cerasulfur® (Ceradis) containing the active ingredients pydiflymetofen and sulfur, respectively, were tested as described in Example 1. Measurements were performed 1 and 2 days after placing the mycelium plug, respectively. The amount of each compound and results are presented as specified in Tables 6 and 7. Results: It is concluded that a combination of sulfur and pydiflumetofen has a synergistic effect against the oomycete Pythium ultimum at ratios from 10:1 to 100:1 (w / w; sulfur:pydiflumetofen). Table 6. Antifungal effect of sulfur (Cerasulfur®, Ceradis) in combination with pydiflumetofen (Saltro®, Syngenta) against Pythium ultimum infection. Sulfur – 2nd ai Avg infected Observed ExpectedO / E Interaction(ppm) area (mm2) % % 0- 0 1344.0 0.050 - 0 1144.1 14.90 - 5 1335.1 0.750 - 5 1111.7 17.3 15.4 1.1 SynergismTable 7. Antifungal effect of sulfur (Cerasulfur®, Ceradis) in combination with pydiflumetofen (Saltro®, Syngenta) against Pythium ultimum infection. Sulfur – 2nd ai Avg infected Observed ExpectedO / E Interaction(ppm) area (mm2) % % 0- 0 5236.6 0.050 - 0 4446.2 15.10 - 0.5 5223.7 0.250 - 0.5 4325.9 17.4 15.3 1.1 Synergism Example 7: Effect of sulfur on clove oil efficacy on Pythium ultimum infection tested on petri dishes. In this experiment, clove oil (Kruidvat) and Cerasulfur® (Ceradis) containing the active ingredient sulfur, were tested as described in Example 1. Measurements were performed 2 days after placing the mycelium plug. The amount of each compound and results are presented as specified in Tables 8 and 9. Results: It is concluded that a combination of sulfur and clove oil has a synergistic effect against the oomycete Pythium ultimum at ratios from 1:1 to 500:1 (w / w; sulfur:clove oil). Table 8. Antifungal effect of sulfur (Cerasulfur®, Ceradis) in combination with clove oil (Kruidvat) against Pythium ultimum infection. Sulfur – 2nd ai Avg infected Observed ExpectedO / E Interaction(ppm) area (mm2) % % 0- 0 4970.8 0.050 - 0 4649.5 6.50 - 50 848.8 82.90 - 10 4357.2 12.350 - 50 486.0 90.2 84.0 1.1 Synergism50 - 10 2957.5 40.5 18.0 2.2 SynergismTable 9. Antifungal effect of sulfur in combination with clove oil (Kruidvat) against Pythium ultimum infection. Sulfur – 2nd ai Avg infected Observed ExpectedO / E Interaction(ppm) area (mm2) % % 0- 0 5280.9 0.050 - 0 4400.8 16.70 - 0.5 5109.5 3.20 - 0.1 5104.7 3.350 - 0.5 4133.6 21.7 19.4 1.1 Synergism50 - 0.1 4165.2 21.1 19.4 1.1 SynergismExample 8: Effect of sulfur on clove oil efficacy on Fusarium graminarum infection tested on petri dishes In this experiment, clove oil (Kruidvat) and Cerasulfur® (Ceradis) containing the active ingredient sulfur, were tested as described in Example 1, with the exception that freshly grown Fusarium graminearum was used. Measurements were performed 3 days after placing the mycelium plug. The amount of each compound and results are presented as specified in Table 10. Results: It is concluded that a combination of sulfur and clove oil has a synergistic effect against Fusarium graminearum at ratios from 10:1 to 20:1 (w / w; sulfur:clove oil). Table 10. Antifungal effect of sulfur (Cerasulfur®, Ceradis) in combination with clove oil (Kruidvat) against Fusarium graminearum infection tested on petri dishes. Sulfur – 2nd ai Avg infected Observed ExpectedO / E Interaction(ppm) area (mm2) % % 0- 0 32.4 0.01000 - 0 29.4 9.30 - 100 8.3 74.50 - 50 19.4 40.11000 - 100 6.1 81.2 76.9 1.1 Synergism1000 - 50 16.9 48.0 45.7 1.1 SynergismExample 9: Effect of sulfur on metalaxyl-M efficacy against Pythium ultimum infection on broccoli seeds. In this experiment, the technical active ingredient metalaxyl-M suspended in water and the product Cerasulfur® (Ceradis) containing the active ingredient sulfur were tested on broccoli seeds. Materials and methods: Broccoli seeds were surface sterilized for 5 minutes by dipping them in a solution of 70 % ethanol. The solution was then removed and the seeds were washed twice with sterile water. The seeds were then placed on absorbing paper and air-dried. For the treatment, 0.16 g of seeds were aliquoted in Eppendorf tubes (2 ml). Sulfur and metalaxyl-M were diluted with sterile water to the final concentrations presented in Table 11. A total volume of 100 microliter of a solution containing sulfur and / or metalaxyl-M was added to 0.16 g of broccoli seeds in the Eppendorf tubes to give the end concentrations as indicated in Table 11. Untreated seeds were incubated in 100 microliters of sterile water as control. The Eppendorf tubes were gently shaken for 10 seconds and then placed horizontally for optimal incubation with the treatments. The Eppendorf tubes were incubated for 24 h. After this incubation, the seeds were spread (in a sterile laminar flow cabinet) over sterile petri dishes to let them dry completely before incubation: 8 seeds were transferred to a petri dish on solid 2% water agar medium. The agar medium was prepared by mixing in a 500 ml Duran bottle 10 g agar (Formedium, Hunstanton, United Kingdom) with 500 ml deionized water and autoclaving the Duran bottle at 120 °C for 15 minutes. After autoclaving, the solution was cooled by placing it in a 48 °C oven for at least two hours. The agar medium in the Duran bottle was divided over 25 petri dishes (90x15mm), 20 ml per petri dish by using 25 ml serological pipets (ROTILABO®; Carl-Roth). In the petri dishes the seeds were distributed evenly in a circle, at a distance of 3,5 cm from the centre of the plates. Once the seeds were divided over the petri dishes, the dishes were placed in an incubator at 22 °C for 16 h dark + 8 h light. Hereafter, a circular agar mycelium plug (circular segment with a height of 5 mm of agar, fully grown with fresh Pythium ultimum mycelium) that was cut out of a petri dish with the broad side of a yellow pipette tip with a diameter of 5 mm (Greiner Bio-One, 200 µl tips) was placed exactly in the center of the petri dish. Hereafter the petri dishes were placed in the incubator at 22 °C. The infection of the broccoli seeds on the petri dishes was assessed 5 days after placing the agar-mycelium plug on the petri dish. The fungal disease development on the seeds was scored by using the following criteria: 0 Healthy germinated seed 1 Transparent root tip (first stage of root infection) 2 Grey area in root (spots of infection are visible in the root) 3 Fully grey root (the roots are completely infected) 4 Root completely infected and infection starts on emerging plantlet 5 Root plus plantlet are fully infected For each treatment, 3 replicates of 8 seeds each were prepared. The average infection scores of the 3 replicates were compared between the different treatments. The percentual efficacy of the treatments was calculated relative to the efficacy of the untreated seeds (incubated in sterile water only) and synergism of the combination of sulfur and metalaxyl-M was calculated using the method of Colby (see general paragraph of the application). Results: It is concluded that a combination of sulfur and metalaxyl-M has a synergistic effect against the oomycete Pythium ultimum at ratios from 1:1 to 10:1 (w / w; sulfur:metalaxyl-M). Table 11. Antifungal effect of sulfur (Cerasulfur®, Ceradis) in combination with metalaxyl-M against Pythium ultimum infection tested on seeds of broccoli. Sulfur – 2nd ai Avg infected Observed ExpectedO / E Interaction(ppm) area (mm2) % % 0- 0 4.1 0.050 - 0 4.2 -0.60 - 50 4.0 3.40 - 5 4.0 2.450 - 50 3.9 6.6 2.9 2.3 Synergism50 - 5 4.0 2.4 1.8 1.3 SynergismExample 10: Effect of sulfur on sodium hydrogencarbonate efficacy on Phytophthora infestans infection tested on tomato plants. In this experiment, baking soda and Cerasulfur® (Ceradis) containing the active ingredients sodium hydrogen carbonate and sulfur, respectively, were tested on tomato plants. Materials and methods: Tomato plants (cultivar MoneyMaker) were grown under greenhouse conditions (22 ⁰C, 12h photoperiod) in standard soil. Three weeks after sowing, plants were individually sprayed with the treatment described in Table 12. One day after spraying, zoospore suspension of Phytophthora infestans was sprayed on the plants. To prepare the zoospore inoculum, Phytophthora infestans was grown on solid pea media plates. For this 120 g of frozen peas were placed in 1L of water which was autoclaved and strained to remove the solid pea parts. Once strained the 15g of agar was added and autoclaved again and finally was poured in petri dishes. The plates inoculated with Phythophthora infestans was kept under conditions that allow the formation of sporangia (15⁰C, 12h photoperiod). After about 2 weeks, on the day of the inoculation, the zoospores were released. To this end, the plates were flooded with ice cold water (3 mm high), the mycelium was scraped and the liquid was placed in a bottle and kept in the fridge for 2 hours. After that, the liquid was filtered with a cheese cloth, the zoospores were counted using a microscope and the concentration of the inoculum was adjusted to 10^5 zoospores / ml. The inoculum was sprayed on the plants using a paint brush. Then the inoculated plants were placed in a closed container containing water on the bottom to preserve a high humidity. The containers were placed in a climate chamber with the following conditions: temperature 22⁰C, 70% relative humidity, 12h photoperiod. Disease symptoms were visually evaluated following a scale of 0 up to 12. Where 0 corresponds to 0% leaf area infected, 1= a few, 2= up to 5%, 3= 5.1 up to 15%, 4= 15.1 to 25%; 5=25.1 to 35%; 6 =35.1 to 45%; 7=45.1 to 55%; 8=55.1 to 65%; 9 =65.1 to 75%; (10) =75.1 to 85%; (11) =85.1 to 95%; (12) = 95.1 to 100% of leaf area infected. For each treatment 10 plants were tested, scoring of data were done 10 days after inoculation. Results: It is concluded that a combination of sulfur and sodium hydrogen carbonate has a synergistic effect against the oomycete Phytophthora infestans at ratios from 1:1.5 to 1:3 (w / w; sulfur: sodium hydrogen carbonate). Table 12. Antifungal effect of sulfur (Cerasulfur®, Ceradis) in combination withsodium hydrogen carbonate (baking soda) against Phytophthora infestans infectiontested on tomato plants. Sulfur – 2nd ai Avg infected Observed ExpectedO / E Interaction(ppm) area (mm2) % % 0- 0 82.0 0.04000 - 0 67.8 17.38000 - 0 64.0 22.00 - 12000 60.0 26.84000 - 12000 46.0 43.9 39.5 1.1 Synergism8000 - 12000 43.0 47.6 42.9 1.1 SynergismExample 11: Effect of sulfur on chitosan efficacy on Phytophthora infestans infection tested on tomato plants. In this experiment, the products Kitogreen® (KitoZyme, Herstal Belgium) and Cerasulfur® (Ceradis) containing the active ingredients chitosan and sulfur, respectively, were tested as described in Example 10. Measurements were performed 4 and 6 days after inoculation with Phythophthora infestans. The amount of each compound and results are presented in Tables 13 and 14. Results: It is concluded that a combination of sulfur and chitosan has a synergistic effect against the oomycete Phytophthora infestans at ratios from 3.2:1 to 8.5:1 (w / w; sulfur:chitosan). Table 13. Antifungal effect of sulfur (Cerasulfur®) in combination with chitosan (Kitogreen®) against Phytophthora infestans infection tested on tomato plants. Sulfur – 2nd ai Avg infected Observed ExpectedO / E Interaction(ppm) area (mm2) % % 0- 0 69.0 0.04000 - 0 47.0 31.98000 - 0 57.0 17.40 - 1250 44.0 36.24000 - 1250 27.0 60.9 56.6 1.1 Synergism8000 - 1250 12.0 82.6 47.3 1.7 SynergismTable 14. Antifungal effect of sulfur (Cerasulfur®, Ceradis) in combination with chitosan (Kitogreen®) against Phytophthora infestans infection tested on tomato plants. Sulfur – 2nd ai Avg infected Observed ExpectedO / E Interaction(ppm) area (mm2) % % 0- 0 94.0 0.04000 - 0 76.0 19.10 - 475 72.0 23.44000 - 475 55.0 41.5 38.1 1.1 SynergismExample 12: Effect of sulfur on sunflower oil and on lecithin efficacies on Phytophthora infestans infection tested on tomato plants. In this experiment, standard sunflower oil from the supermarket or lecithin, together with the product Cerasulfur® (Ceradis) containing the active ingredient sulfur, were tested as described in Example 10. Measurements were performed 10 days after inoculation with Phythophthora infestans. The amount of each compound and results are presented as specified in Table 15. Results: It is concluded that combinations of sulfur with sunflower oil and sulfur with lecithin have a synergistic effect against the oomycete Phytophthora infestans at ratios 2.6:1 and 2.9:1 (w / w; sulfur:sunflower oil; sulfur:lecithin, respectively). Table 15. Antifungal effect of sulfur (Cerasulfur®, Ceradis) in combination withsunflower oil or lecithin against Phytophthora infestans infection tested on tomatoplants. Sulfur – 2nd ai Avg infected Observed ExpectedO / E Interaction(ppm) area (mm2) % % Sunflower oil 0- 0 90.0 0.08000 - 0 80.0 11.10 - 3000 82.0 8.98000 - 3000 69.0 23.3 19.0 1.2 SynergismLecithin 0- 0 90.0 0.04000 - 0 71.0 21.10 - 1375 88.0 2.24000 - 1375 60.0 33.3 22.9 1.5 SynergismExample 13: Effect of sulfur on neem oil efficacy on Pythium ultimum infection tested on petri dishes In this experiment, neem oil and Cerasulfur® (Ceradis) containing the active ingredient sulfur, were tested as described in Example 1. Measurements were performed 1 day after placing the mycelium plug. The amount of each compound and results are presented as specified in Table 16. Results: It is concluded that a combination of sulfur and neem oil has a synergistic effect against Pythium ultimum at ratios from 1:1 to 20:1 (w / w; sulfur:neem oil). Table 16. Antifungal effect of sulfur (Cerasulfur®, Ceradis) in combination with neem oil against Pythium ultimum infection. Sulfur – 2nd ai Avg infected Observed ExpectedO / E Interaction(ppm) area (mm2) % % 0- 0 1803.5 0.050 - 0 1552.4 13.90 - 50 1837.4 -1.90 - 25 1841.4 -2.10 - 10 1848.8 -2.50 - 5 1779.8 1.30 - 2.5 1854.8 -2.850 - 50 1455.0 19.3 12.3 1.6 Synergism50 - 25 1464.7 18.8 12.1 1.6 Synergism50 - 10 1524.1 15.5 11.8 1.3 Synergism50 - 5 1441.9 20.1 15.1 1.3 Synergism50 - 2.5 1477.2 18.1 11.5 1.6 Synergism Example 14: Effect of sulfur on Bacillus amyloliquefaciens efficacy on Pythium ultimum infection tested on petri dishes In this experiment, the products Serenade® (Bayer) and Cerasulfur® (Ceradis) containing the active ingredient Bacillus amyloliquefaciens and sulfur, respectively, were tested as described in Example 1. In the case of Bacillus amyloliquefaciens, combinations with sulfur were tested using the colony-forming unit (CFU) as dose rate (e.g 500000 and 250000 CFU of Bacillus amyloliquefaciens per Liter). Using the weight of product according to the related CFU we estimated a ppm value to be tested as 0.5ppm and 0.25ppm for the 500 000 and 250000 CFU / L (Table 17). The amount of each compound and results are presented as specified in Table 17. Measurements were performed 1 day after placing the mycelium plug. Results: It is concluded that a combination of sulfur and Bacillus amyloliquefaciens has a synergistic effect against Pythium ultimum at ratios from 100:1 to 200:1 (w / w; sulfur: Bacillus amyloliquefaciens). Table 17. Antifungal effect of sulfur (Cerasulfur®, Ceradis) in combination with Bacillus amyloliquefaciens (Serenade®, Bayer) against Pythium ultimum infection. Sulfur – 2nd ai Avg infected Observed ExpectedO / E Interaction(ppm) area (mm2) % % 0- 0 909.3 0.050 - 0 763.1 16.10 - 0.5 967.7 -6.40 - 0.25 967.8 -6.450 - 0.5 735.9 19.1 10.7 1.8 Synergism50 - 0.25 782.7 13.9 10.7 1.3 SynergismExample 15: Effect of sulfur on yeast based substance efficacy on Powdery mildew infection tested on cucumber plants In this experiment, the products Romeo® (Agrauxine Lesaffre) and Cerasulfur® (Ceradis) containing the active ingredients Cerevisane® yeast based substance and sulfur, respectively, were tested. The amount of each compound and results are presented as specified in Table 18. Powdery mildew inoculum was produced on cucumber plants in the greenhouse. For the experiment, 3-week-old cucumber plants were individually sprayed with the treatment until fully covered. One day after the treatment, the plants were inoculated with powdery mildew by gently taping the treated leaf with a leaf infested with powdery mildew. The plants were placed under a plastic in the greenhouse (22°C, 70% RH and 12h photoperiod) for 14 days. After 7 days the powdery mildew disease severity was evaluated by visual observations based on disease grading scale with 11 categories ranging from 0-100%. The total leaf area infected (covered by mycelia), as follows: (0) = 0% leaf area infected; (1)=1 to 9%; (2) =10 to 19%; (3) =20 to 29%; (4) =30 to 39%; (5) =40 to 49%; (6) =50 to 59%; (7) =60 to 69%; (8) =70 to 79%; (9) =80 to 89%; (10) =90 to 99% and (11) =100% of leaf area infected. For each treatment 5 plants were used. Results: It is concluded that a combination of sulfur and yeast based substance has a synergistic effect against powdery mildew at ratios from 2:1 to 6:1 (w / w; sulfur:Cerevisane®). Table 18. Antifungal effect of sulfur (Cerasulfur®, Ceradis) in combination with yeast based substance (Romeo®, Cerevisane®, Agrauxine Lesaffre) againstpowdery mildew disease tested on cucumber plants.Sulfur – 2nd ai Avg infected Observed ExpectedO / E Interaction(ppm) area (mm2) % % 0- 0 88 02000 - 0 38 56.80 - 1000 52 40.90 - 330 54 38.62000 - 1000 18 79.5 74.5 1.1 Synergism2000 - 330 17 80.7 73.5 1.1 SynergismExample 16: Effect of sulfur on thymol and on carvacrol efficacies on Botrytis cinerea infection tested on petri dishes. In this experiment, carvacrol and thymol and the product Cerasulfur® (Ceradis) containing the active ingredient sulfur, were tested as described in Example 1, with the exception that 5µl of spore suspension at a concentration of 10^6 spores / ml was used instead of a plug. The amount of each compound and results are presented as specified in Table 19. Measurements were performed 5 days after inoculation with Botrytis cinerea. Results: It is concluded that combinations of sulfur with carvacrol and sulfur with thymol have a synergistic effect against the Botrytis cinerea at ratios 9:1 to 6:1 (w / w; sulfur:carvacrol; sulfur:thymol). Table 19. Antifungal effect of sulfur (Cerasulfur®, Ceradis) in combination withcarvacrol or thymol against Botrytis cinerea infection tested on petri dishes.Sulfur – 2nd ai Avg infected Observed ExpectedO / E Interaction(ppm) area (mm2) % % Carvacrol 0- 0 5160.0 0.00 - 12 5334.7 -3.4108 - 0 3853.2 25.392 - 0 3815.5 26.181 - 0 3490.1 32.470 - 0 3687.7 28.5108 - 12 3198.2 38.0 22.8 1.7 Synergism92 - 12 3197.4 38.0 23.6 1.6 Synergism81 - 12 3424.3 33.6 30.1 1.1 Synergism70 - 12 3200.7 38.0 26.1 1.5 SynergismThymol 0- 0 5160.0 0.00 - 12 5336.2 -3.4108 - 0 3853.2 25.392 - 0 3815.5 26.181 - 0 3490.1 32.4108 - 12 3574.6 30.7 22.8 1.3 3574.692 - 12 3699.2 28.3 23.5 1.2 3699.281 - 12 2975.5 42.3 30.1 1.4 2975.5Example 17: Effect of sulfur on acetic acid efficacies on Fusarium graminearum infection tested on petri dishes. In this experiment, acetic acid and the product Cerasulfur® (Ceradis) containing the active ingredient sulfur, were tested as described in Example 1, with the exception that a plug comprising Fusarium graminearum was used. Measurements were performed 3 days after inoculation with Fusarium graminearum. The amount of each compound and results are presented as specified in Table 20. Results: It is concluded that combinations of sulfur with acetic acid synergistic effect against the Fusarium graminearum at ratio 2.5:1 (w / w; sulfur:acetic acid). Table 20. Antifungal effect of sulfur (Cerasulfur®, Ceradis) in combination withacetic acid against Fusarium graminearum infection.Sulfur – 2nd ai Avg infected Observed ExpectedO / E Interaction(ppm) area (mm2) % % 0- 0 32.4 0.01000 - 0 29.4 9.30 - 400 23.0 29.01000 - 400 18.9 41.6 35.6 1.2 SynergismExample 18: Effect of sulfur on copper sulfate, natamycin, and potassium hydrogen bicarbonate efficacies on Pythium ultimum infection tested on petri dishes In this experiment, potassium hydrogen bicarbonate and the products Kocide® 2000 (Corteva Agriscience), Ceramax® (Ceradis) and Cerasulfur® (Ceradis) containing the active ingredients copper sulfate, natamycin and sulfur, respectively, were tested as described in Example 1. Measurements were performed 1 or 2 days after placing the mycelium plug. The amount of each compound and results are presented as specified in Table 21. Results: It is concluded that combinations of sulfur with copper sulfate, sulfur with natamycin, and sulfur with potassium hydrogen bicarbonate have a synergistic effects against Pythium ultimum at ratios 1:1, 100:1, and 50:1 (w / w; sulfur:copper sulfate; sulfur:natamycin, sulfur:potassium hydrogen bicarbonate, respectively). Table 21. Antifungal effect of sulfur (Cerasulfur®, Ceradis) in combination withcopper sulfate, natamycin or potassium hydrogen bicarbonate against Pythiumultimum infection tested on petri dishes. Sulfur – 2nd ai Avg infected Observed ExpectedO / E Interaction(ppm) area (mm2) % % Copper sulfate (1 day after plug placement) 0- 0 561.3 0.0100 - 0 418.3 25.50 - 100 496.5 11.5100 - 100 176.1 68.6 34.1 2.0 SynergismNatamycin (2 days after plug placement) 0- 0 3599.3 0.050 - 0 3418.3 5.00 - 0.5 3581.1 0.550 - 0.5 3058.9 15.0 5.5 2.7 Synergism Potassium hydrogen bicarbonate (2 days after plug placement) 0- 0 713.9 0.050 - 0 601.5 15.70 - 1 727.5 -1.950 - 1 594.8 16.7 14.1 1.2 SynergismExample 19: Effect of sulfur on beta-1,3(4)-glucanase efficacies on nematode infection tested in microtiter plate. In this experiment, beta-1,3(4)-glucanase and Cerasulfur® (Ceradis) containing the active ingredient sulfur were tested against nematodes. For this 24-well plates were used. Each well contained, at start, about 200 nematodes (Meloidogyne incognita) at second-stage juvenile (J2) in 0.4 mL water. To that 0.6 mL of treatment was added to reach a final volume of 1 mL per well. The effect of the treatment was assessed after 168 hours by assessing the motility of the first 20 encountered individuals. Since the wells were not transparent, 0.5ml was removed from each well and diluted to observe nematode motility. The amount of each compound and results are presented as specified in Table 22. Results: It is concluded that combination of sulfur with beta-1,3(4)-glucanase have a synergistic effects against nematodes at ratio 11.2:1 (w / w; sulfur:beta-1,3(4)- glucanase). Table 22. Anti-nematocidial effect of sulfur (Cerasulfur®, Ceradis) in combinationwith beta-1,3(4)-glucanase against nematodes infection tested in microtiter plates.Sulfur – 2nd ai Avg infected Observed ExpectedO / E Interaction(ppm) area (mm2) % % 0- 0 95.0 0.028000 - 0 88.8 6.60 - 2500 76.3 19.728000 - 2500 27.5 71.1 25.0 2.8 SynergismExample 20: Effect of sulfur on paraffinic oil efficacy on Pythium ultimum infection tested on petri dishes In this experiment, paraffinic oil (Carl Roth) and Cerasulfur® (Ceradis) containing the active ingredient sulfur, were tested as described in Example 1. Measurements were performed 2 days after placing the mycelium plug. The amount of each compound and results are presented as specified in Table 23. Results: It is concluded that a combination of sulfur and paraffinic oil has a synergistic effect against Pythium ultimum at ratios from 1:1 to 50:1 (w / w; sulfur:paraffinic oil). Table 23. Antifungal effect of sulfur (Cerasulfur®, Ceradis) in combination with paraffinic oil (Carl Roth) against Pythium ultimum infection tested on petri dishes. Sulfur – 2nd ai Avg infected Observed ExpectedO / E Interaction(ppm) area (mm2) % % 0- 0 5214.2 0.050 - 0 4107.1 21.20 - 50 5410.4 -3.80 - 10 5335.6 -2.30 - 5 5473.7 -5.00 - 1 5301.4 -1.750 - 50 3875.2 25.7 18.3 1.4 Synergism50 - 10 3896.6 25.3 19.4 1.3 Synergism50 - 5 3982.8 23.6 17.3 1.4 Synergism50 - 1 4090.4 21.6 19.9 1.1 SynergismExample 21: Effect of sulfur on propamocarb efficacy on Pythium ultimum infection tested on petri dishes. In this experiment, the products Proplant® (Arysta LifeSciences) and Cerasulfur® (Ceradis) containing the active ingredients propamocarb and sulfur, respectively, were tested as described in Example 1. Measurements were performed 1 day after placing the mycelium plug. The amount of each compound and results are presented in Table 24. Results: It is concluded that a combination of sulfur and propamocarb has a synergistic effect against the oomycete Pythium ultimum at ratios from 50:1 to 1:1 (w / w; sulfur:propamocarb). Table 24. Antifungal effect of sulfur (Cerasulfur®, Ceradis) in combination with propamocarb (Proplant®, Arysta LifeSciences) against Pythium ultimum infection tested on petri dishes. Sulfur – 2nd ai Avg infected Observed ExpectedO / E Interaction(ppm) area (mm2) % % 0- 0 5148.5 0.050 - 0 1076.60 16.7710 - 0 1183.28 8.530 - 10 571.88 55.790 - 4 781.86 39.560 - 1 1128.26 12.7850 - 10 435.03 66.37 63.21 1.1 Synergism50 - 4 575.75 55.49 49.70 1.1 Synergism50 - 1 845.57 34.63 27.41 1.3 Synergism10 - 10 467.02 63.90 59.56 1.1 Synergism10 - 4 609.42 52.89 44.71 1.2 Synergism10 - 1 892.50 31.00 20.22 1.5 SynergismExample 22: Effect of sulfur on limonene and on garlic extract efficacies on Pythium ultimum infection tested on petri dishes. In this experiment, limonene or the product Nemguard® (BioGard) containing the active ingredients garlic extract, were tested together with the product Cerasulfur® (Ceradis) containing the active ingredient sulfur as described in Example 1. Measurements were performed 1 day after placing the mycelium plug. The amount of each compound and results are presented in Table 25. Results: It is concluded that combinations of sulfur with limonene and sulfur with garlic extract have a synergistic effect against the oomycete Pythium ultimum at ratios from 10:1 to 1:10 (w / w; sulfur:limonene or sulfur:garlic extract). Table 25. Antifungal effect of sulfur (Cerasulfur®, Ceradis) in combination with limonene or garlic extract (Nemguard®, BioGard) against Pythium ultimum infection tested on petri dishes. Sulfur – 2nd ai Avg infected Observed ExpectedO / E Interaction(ppm) area (mm2) % % 0- 0 1092.82 0.0050 - 0 965.10 11.6910 - 0 1013.56 7.25Limonene 0- 100 1146.73 -4.930 - 50 1196.41 -9.480 - 5 1096.24 -0.3150 - 100 900.22 17.62 7.33 2.4 Synergism50 - 50 869.46 20.44 3.32 6.2 Synergism50 - 5 825.56 24.46 11.41 2.1 Synergism10 - 100 869.62 20.42 2.68 7.6 Synergism10 - 5 890.65 18.50 6.96 2.7 SynergismGarlic extract0 - 100 994.91 8.960 - 50 1029.78 5.770 - 5 1144.19 -4.7050 - 100 737.90 32.48 19.60 1.7 Synergism50 - 50 769.99 29.54 16.78 1.8 Synergism50 - 5 822.33 24.75 7.54 3.3 Synergism10 - 100 716.87 34.40 15.56 2.2 Synergism10 - 50 774.49 29.13 12.60 2.3 Synergism10 - 5 845.62 22.62 2.89 7.8 SynergismExample 23: Effect of sulfur on maize oil and on soybean oil efficacies on Pythium ultimum infection tested on petri dishes. In this experiment, standard soybean oil from the supermarket or maize oil together with the product Cerasulfur® (Ceradis) containing the active ingredient sulfur as described in Example 1. Measurements were performed 1 day after placing the mycelium plug. The amount of each compound and results are presented in Table 26. Results: It is concluded that combinations of sulfur with maize oil and sulfur with soybean oil have a synergistic effect against the oomycete Pythium ultimum at ratios from 10:1 to 1:10 (w / w; sulfur:maize oil or sulfur:soybean oil). Table 26. Antifungal effect of sulfur (Cerasulfur®, Ceradis) in combination with maize oil or soybean oil against Pythium ultimum infection tested on petri dishes. Sulfur – 2nd ai Avg infected Observed ExpectedO / E Interaction(ppm) area (mm2) % % 0- 0 3075.44 0.0050 - 0 2455.04 20.1710 - 0 2604.75 15.30Maize oil 0- 100 2935.34 4.560 - 50 2958.28 3.810 - 5 3085.65 -0.3350 - 100 2084.21 32.23 23.81 1.4 Synergism50 - 50 2026.95 34.09 23.21 1.5 Synergism50 - 5 2196.31 28.59 19.91 1.4 Synergism10 - 100 2139.18 30.44 19.16 1.6 Synergism10 - 50 2333.91 24.11 18.53 1.3 Synergism10 - 5 2402.74 21.87 15.02 1.5 SynergismSoybean oil 0- 100 2830.83 7.950 - 50 2969.10 3.460 - 5 2911.58 5.3350 - 100 2117.85 31.14 26.52 1.2 Synergism50 - 50 2110.92 31.36 22.93 1.4 Synergism50 - 5 2264.72 26.36 24.43 1.1 Synergism10 - 100 2327.02 24.34 22.04 1.1 Synergism10 - 50 2310.74 24.86 18.23 1.4 SynergismExample 24: Effect of sulfur on geraniol efficacy on Rhizoctonia solani infection tested on petri dishes. In this experiment, the active ingredient geraniol together with the product Cerasulfur® (Ceradis) containing the active ingredient sulfur, was tested together with the product Cerasulfur® (Ceradis) containing the active ingredient sulfur as described in Example 1. Measurements were performed 1 day after placing the mycelium plug. The amount of each compound and results are presented in Table 27. Results: It is concluded that combination of sulfur with geraniol has a synergistic effect against the fungus Rhizoctonia solani at ratios from 50:1 to 1:5 (w / w; sulfur:geraniol). Table 27. Antifungal effect of sulfur (Cerasulfur®, Ceradis) in combination with geraniol against Rhizoctonia solani infection tested on petri dishes. Sulfur – 2nd ai Avg infected Observed ExpectedO / E Interaction(ppm) area (mm2) % % 0- 0 540.7 0.050 - 0 476.2 11.910 - 0 522.3 3.40 - 50 308.6 42.90 - 10 384.6 28.90 - 1 541.8 -0.250 - 50 195.6 63.8 49.7 1.3 Synergism50 - 10 325.1 39.9 37.4 1.1 Synergism50 - 1 417.4 22.8 11.7 1.9 Synergism10 - 50 229.8 57.5 44.9 1.3 Synergism10 - 1 434.8 19.6 3.2 6.1 SynergismExample 25: Effect of sulfur on horsetail plant extract efficacy on Pythium ultimum infection tested on petri dishes. In this experiment, horsetail plant extract (Kruidvat) and Cerasulfur® (Ceradis) containing sulfur, was tested as described in Example 1. Measurements were performed 2 days after placing the mycelium plug. The amount of each compound and results are presented in Table 28. Results: It is concluded that a combination of sulfur and horsetail extract has a synergistic effect against the oomycete Pythium ultimum at ratios from 50:1 to 1:1 (w / w; sulfur:horsetail extract). Table 28. Antifungal effect of sulfur (Cerasulfur®, Ceradis) in combination with horsetail extract against Pythium ultimum infection tested on petri dishes. Sulfur – 2nd ai Avg infected Observed ExpectedO / E Interaction(ppm) area (mm2) % % 0- 0 5194.31 0.0050 - 0 4525.42 12.880 - 50 5106.12 1.700 - 25 5200.77 -0.120 - 10 5254.31 -1.160 - 1 5235.79 -0.8050 - 50 4392.46 15.44 14.36 1.1 Synergism50 - 25 4275.67 17.69 12.77 1.4 Synergism50 - 10 4317.21 16.89 11.87 1.4 Synergism50 - 1 4269.90 17.80 12.18 1.5 SynergismExample 26: Effect of sulfur on copper oxychloride efficacy on Pythium ultimum infection tested on petri dishes. In this experiment, Pasta caffaro® (Gowan) and Cerasulfur® (Ceradis) containing copper oxychloride and sulfur, respectively, was tested as described in Example 1. Measurements were performed 1 day after placing the mycelium plug. The amount of each compound and results are presented in Table 29. Results: It is concluded that a combination of sulfur and copper oxychloride has a synergistic effect against the oomycete Pythium ultimum at ratios from 25:1 to 1:2 (w / w; sulfur:copper oxychloride). Table 29. Antifungal effect of sulfur (Cerasulfur®, Ceradis) in combination with horsetail extract against Pythium ultimum infection tested on petri dishes. Sulfur – 2nd ai Avg infected Observed ExpectedO / E Interaction(ppm) area (mm2) % % 0- 0 3702.94 0.0050 - 0 3115.56 15.860 - 100 2415.99 34.750 - 50 2576.70 30.410 - 10 3765.94 -1.700 - 2 3805.42 -2.7750 - 100 462.08 87.52 45.10 1.9 Synergism50 - 50 1791.43 51.62 41.45 1.2 Synergism50 - 10 3093.13 16.47 14.43 1.1 Synergism50 - 2 2996.75 19.07 13.53 1.4 SynergismExample 27: Effect of sulfur on zoxamide efficacy on Pythium ultimum infection tested on petri dishes. In this experiment, Zoxium SC 240® (Gowan) and Cerasulfur® (Ceradis) containing zoxamide and sulfur, respectively, was tested as described in Example 1. Measurements were performed 1 day after placing the mycelium plug. The amount of each compound and results are presented in Table 30. Results: It is concluded that a combination of sulfur and zoxamide has a synergistic effect against the oomycete Pythium ultimum at ratios from 100:1 to 1:2 (w / w; sulfur:zoxamide). Table 30. Antifungal effect of sulfur (Cerasulfur®, Ceradis) in combination with zoxamide (Zoxium SC 240®, Gowan) against Pythium ultimum infection tested on petri dishes. Sulfur – 2nd ai Avg infected Observed ExpectedO / E Interaction(ppm) area (mm2) % % 0- 0 804.88 0.0050 - 0 763.94 5.090 - 25 185.54 76.950 - 5 175.36 78.210 - 0.5 168.46 79.0750 - 25 108.03 86.58 78.12 1.1 Synergism50 - 5 118.99 85.22 79.32 1.1 Synergism50 - 0.5 107.75 86.61 80.13 1.1 SynergismExample 28: Effect of sulfur on fluopyram efficacy on Pythium ultimum infection tested on petri dishes. In this experiment, Luna Privilege® (Bayer) and Cerasulfur® (Ceradis) containing fluopyram and sulfur, respectively, was tested as described in Example 1. Measurements were performed 1 day after placing the mycelium plug. The amount of each compound and results are presented in Table 31. Results: It is concluded that a combination of sulfur and fluopyram has a synergistic effect against the oomycete Pythium ultimum at ratios from 25:1 to 1:1 (w / w; sulfur:fluopyram). Table 31. Antifungal effect of sulfur (Cerasulfur®, Ceradis) in combination with fluopyram (Luna Privilege® Bayer) against Pythium ultimum infection tested on petri dishes. Sulfur – 2nd ai Avg infected Observed ExpectedO / E Interaction(ppm) area (mm2) % % 0- 0 1129.19 0.0050 - 0 1097.44 2.810 - 50 999.91 11.450 - 2 1027.95 8.9750 - 50 910.84 19.34 13.94 1.4 Synergism50 - 2 985.62 12.71 11.53 1.1 SynergismExample 29: Effect of sulfur on mefentrifluconazole efficacy on Pythium ultimum infection tested on petri dishes. In this experiment, Revysion® (BASF) and Cerasulfur® (Ceradis) containing mefentrifluconazole and sulfur, respectively, was tested as described in Example 1. Measurements were performed 1 day after placing the mycelium plug. The amount of each compound and results are presented in Table 32. Results: It is concluded that a combination of sulfur and mefentrifluconazole has a synergistic effect against the oomycete Pythium ultimum at ratios from 1:1 to 1:2 (w / w; sulfur: mefentrifluconazole). Table 32. Antifungal effect of sulfur (Cerasulfur®, Ceradis) in combination with mefentrifluconazole (Revysion® BASF) against Pythium ultimum infection tested on petri dishes. Sulfur – 2nd ai Avg infected Observed ExpectedO / E Interaction(ppm) area (mm2) % % 0- 0 2392.91 0.0050 - 0 2189.82 8.490 - 100 2073.83 13.330 - 50 2282.94 4.6050 - 100 1785.87 25.37 20.69 1.2 Synergism50 - 50 2050.18 14.32 12.69 1.1 SynergismExample 30: Effect of sulfur on dicloran efficacy on Pythium ultimum infection tested on petri dishes. In this experiment, Botran® (Gowan) and Cerasulfur® (Ceradis) containing dicloran and sulfur, respectively, was tested as described in Example 1. Measurements were performed 1 day after placing the mycelium plug. The amount of each compound and results are presented in Table 33. Results: It is concluded that a combination of sulfur and dicloran has a synergistic effect against the oomycete Pythium ultimum at ratios from 5:1 to 1:2 (w / w; sulfur: dicloran). Table 33. Antifungal effect of sulfur (Cerasulfur®, Ceradis) in combination with dicloran (Botran® Gowan) against Pythium ultimum infection tested on petri dishes. Sulfur – 2nd ai Avg infected Observed ExpectedO / E Interaction(ppm) area (mm2) % % 0- 0 1875.41 0.0050 - 0 1704.92 9.090 - 100 1201.31 35.940 - 50 1161.47 38.070 - 10 1757.70 6.2850 - 100 877.51 53.21 41.77 1.3 Synergism50 - 50 802.87 57.19 43.70 1.3 Synergism50 - 10 1121.48 40.20 14.80 2.7 SynergismExample 31: Effect of sulfur on Swinglea glutinosa plant extract efficacy on Pythium ultimum infection tested on petri dishes. In this experiment, Ecoswing® (Gowan) and Cerasulfur® (Ceradis) containing Swinglea glutinosa plant extract and sulfur, respectively, was tested as described in Example 1. Measurements were performed 1 day after placing the mycelium plug. The amount of each compound and results are presented in Table 34. Results: It is concluded that a combination of sulfur and Swinglea glutinosa plant extract has a synergistic effect against the oomycete Pythium ultimum at ratios from 5:1 to 1:2 (w / w; sulfur: Swinglea glutinosa). Table 34. Antifungal effect of sulfur (Cerasulfur®, Ceradis) in combination with Swinglea glutinosa extract (Ecoswing® Gowan)) against Pythium ultimum infection tested on petri dishes. Sulfur – 2nd ai Avg infected Observed ExpectedO / E Interaction(ppm) area (mm2) % % 0- 0 2189.82 8.4950 - 0 2073.83 13.330 - 100 2282.94 4.600 - 50 2189.82 8.4950 - 100 1785.87 25.37 20.69 1.2 Synergism50 - 50 2050.18 14.32 12.69 1.1 SynergismExample 32: Effect of sulfur on zoxamide efficacy on Pythium ultimum infection tested on petri dishes. In this experiment, Zoxium SC 240® (Gowan) and Cerasulfur® (Ceradis) containing zoxamide and sulfur, respectively, was tested as described in Example 1. Measurements were performed 1 day after placing the mycelium plug. The amount of each compound and results are presented in Table 35. Results: It is concluded that a combination of sulfur and zoxamide has a synergistic effect against the oomycete Pythium ultimum at ratios from 1000:1 to 500:1 (w / w; sulfur:zoxamide). Table 35. Antifungal effect of sulfur (Cerasulfur®, Ceradis) in combination with zoxamide (Zoxium SC 240®, Gowan) against Pythium ultimum infection tested on petri dishes. Sulfur – 2nd ai Avg infected Observed ExpectedO / E Interaction(ppm) area (mm2) % % 0- 0 145.52 0.0050 - 0 123.43 15.180 - 0.1 118.61 18.490 - 0.05 140.91 3.1650 - 0.1 61.27 57.89 30.86 1.4 Synergism50 - 0.05 81.35 44.10 17.86 5.6 Synergism

Claims

Claims 1. A composition comprising sulfur and a 2ndactive ingredient (ai), in a ratio of 1000:1 – 1:100 (w / w; sulfur: 2ndai), preferably 750:1 - 1:50 (w / w; sulfur: 2ndai) and, optionally, one or more surfactants, wherein the 2ndai is a pesticide selected from clove oil, zoxamide, pydiflumetofen, metalaxyl-M, folpet, propamocarb, fluopyram, mandipropamid, fluopicolide, dithianon, dicloran, benthiavalicarb isopropyl, bixafen, thifluzamide, isopyrazam, adepidyn, mefentrifluconazole, metconazole, copper oxychloride, an enzyme such as beta-glucanase preferably beta-1,3(4)-glucanase, pyrimethanil, boscalid, abamectin, dodine, chitosan, copper sulfate, chitosan hydrochloride, COS-OGA, onion extract, nettle extract, mustard extract, horsetail extract, silicic acid, willow extract, swinglea glutinosa extract, fructose, sucrose, sodium hydrogen carbonate, calcium hydroxide, magnesium hydroxide, sunflower oil, maize oil, soyabean oil, onion oil, lecithin, neem oil, activated charcoal, bentonite, thymol, carvacrol, eugenol, geraniol, limonene, acetic acid, natamycin, potassium hydrogen bicarbonate, paraffinic oil, aluminium sulfate, fatty acid, garlic extract, a phosphonate or a salt thereof, laminarine and a microorganism, including an extract of a microorganism, selected from a Trichoderma species, a yeast-based substance, a Bacillus species such as B. amyloliquefaciens, a Rhizobium species and any combination thereof. 2 The composition of claim 1, wherein the 2ndai is selected from clove oil, zoxamide, pydiflumetofen, metalaxyl-M, propamocarb, fluopyram, mefentrifluconazole, dicloran, copper oxychloride, Swinglea glutinosa extract, beta- 1,3(4)-glucanase, chitosan, pyrimethanil, boscalid, abamectin, chitosan, copper sulfate, horsetail extract, sodium hydrogen carbonate, sunflower oil, maize oil, soyabean oil, lecithin, neem oil, thymol, carvacrol, geraniol, limonene, acetic acid, natamycin, potassium hydrogen bicarbonate, paraffinic oil, garlic extract, a yeast- based substance, a Bacillus species such as B. amyloliquefaciens, and any combination thereof.

3. The composition of claim 1 or claim 2, wherein the 2ndai is selected from Bacillus thuringiensis, B. amyloliquefaciens, B. thuringiensis, B. subtilis, B. pulilus and any combination thereof, preferably 2ndai is B. amyloliquefaciens.

4. The composition of any one of claims 1-3, further comprising at least one antifoaming agent, at least one thickening agent and / or rheology agent, at least one stabilizing agent, glycerol, or any combination thereof.

5. A method for protecting a plant and / or plant part and / or a soil against a pest and / or for treating a plant and / or plant part and / or soil that is affected by a pest, comprising the steps of: (a) providing sulfur and a 2ndactive ingredient (ai), in a ratio of 1000:1 – 1:100 (w / w; sulfur: 2ndai), preferably 750:1 - 1:50 (w / w; sulfur: 2ndai); (b) applying the sulfur and 2ndai to said plant and / or plant part and / or soil, wherein the 2ndai is selected from clove oil, zoxamide, pydiflumetofen, metalaxyl- M, folpet, propamocarb, fluopyram, mandipropamid, fluopicolide, dithianon, dicloran, benthiavalicarb isopropyl, bixafen, thifluzamide, isopyrazam, adepidyn, mefentrifluconazole, metconazole, copper oxychloride, an enzyme such as beta- glucanase preferably beta-1,3(4)-glucanase, pyrimethanil, boscalid, abamectin, dodine, chitosan, copper sulfate, chitosan hydrochloride, COS-OGA, onion extract, nettle extract, mustard extract, horsetail extract, silicic acid, willow extract, swinglea glutinosa extract, fructose, sucrose, sodium hydrogen carbonate, calcium hydroxide, magnesium hydroxide, sunflower oil, maize oil, soyabean oil, onion oil, lecithin, neem oil, activated charcoal, bentonite, thymol, carvacrol, eugenol, geraniol, limonene, acetic acid, natamycin, potassium hydrogen bicarbonate, paraffinic oil, aluminium sulfate, fatty acid, garlic extract, a phosphonate or a salt thereof, laminarine and a microorganism, including an extract of a microorganism, selected from a Trichoderma species, a yeast-based substance, a Bacillus species such as B. amyloliquefaciens, a Rhizobium species and any combination thereof, wherein the pest is a nematode and / or a fungus, including an ascomycete and a basidiomycete, and / or a oomycete.

6. The method according to claim 5, whereby said sulfur and 2ndai are provided by a composition of any one of claims 1-4.

7. The method of claim 5 or claim 6, wherein said plant part is a seed, bulb, root, leaf, flower, fruit or vegetable.

8. The method according to claim 5 or claim 7, whereby said sulfur and 2ndactive ingredient (ai) are provided sequentially to the plant, plant part, or soil, whereby the sulfur or 2ndai is applied first to a plant, plant part, or soil, followed by the remaining of the sulfur or 2ndai, preferably said remaining of the sulfur or 2ndai may be applied after 2 days, 4 days, 6 days, 7 days, 8 days, 10 days, 12 days, 14 days, 16 days, 18 days and / or 20 days after applying the first sulfur or 2ndai.

9. The method according to any one of claims 5-8, wherein the pest is an oomycete.

10. The method according to any one of claims 5-8, wherein the pest is a nematode and / or a fungus.

11. The method according to any one of claims 5-10, wherein the 2ndai is selected from clove oil, zoxamide, pydiflumetofen, metalaxyl-M, propamocarb, fluopyram, mefentrifluconazole, dicloran, copper oxychloride, Swinglea glutinosa extract, beta- 1,3(4)-glucanase, chitosan, pyrimethanil, boscalid, abamectin, chitosan, copper sulfate, horsetail extract, sodium hydrogen carbonate, sunflower oil, maize oil, soyabean oil, lecithin, neem oil, thymol, carvacrol, geraniol, limonene, acetic acid, natamycin, potassium hydrogen bicarbonate, paraffinic oil, garlic extract, a yeast- based substance, a Bacillus species such as B. amyloliquefaciens, and any combination thereof.

12. Use of sulfur for enhancing the activity of a 2ndai against a nematode and / or a fungus, including an ascomycete and basidiomycete and / or an oomycete, wherein 2ndai is selected from clove oil, zoxamide, pydiflumetofen, metalaxyl-M, folpet, propamocarb, fluopyram, mandipropamid, fluopicolide, dithianon, dicloran,benthiavalicarb isopropyl, bixafen, thifluzamide, isopyrazam, adepidyn, mefentrifluconazole, metconazole, copper oxychloride, an enzyme such as beta- glucanase preferably beta-1,3(4)-glucanase, pyrimethanil, boscalid, abamectin, dodine, chitosan, copper sulfate, chitosan hydrochloride, COS-OGA, onion extract, nettle extract, mustard extract, horsetail extract, silicic acid, willow extract, swinglea glutinosa extract, fructose, sucrose, sodium hydrogen carbonate, calcium hydroxide, magnesium hydroxide, sunflower oil, maize oil, soyabean oil, onion oil, lecithin, neem oil, activated charcoal, bentonite, thymol, carvacrol, eugenol, geraniol, limonene, acetic acid, natamycin, potassium hydrogen bicarbonate, paraffinic oil, aluminium sulfate, fatty acid, garlic extract, a phosphonate or a salt thereof, laminarine and a microorganism, including an extract of a microorganism, selected from a Trichoderma species, a yeast-based substance, a Bacillus species such as B. amyloliquefaciens, a Rhizobium species and any combination thereof.

13. Use of sulfur and a 2ndai for protecting a plant and / or plant part and / or soil against a pest and / or treating a plant and / or plant part and / or soil affected by a pest, wherein the pest is a nematode and / or a fungus, including an ascomycete and basidiomycete and / or an oomycete, wherein 2ndai is selected from clove oil, zoxamide, pydiflumetofen, metalaxyl-M, folpet, propamocarb, fluopyram, mandipropamid, fluopicolide, dithianon, dicloran, benthiavalicarb isopropyl, bixafen, thifluzamide, isopyrazam, adepidyn, mefentrifluconazole, metconazole, copper oxychloride, an enzyme such as beta- glucanase preferably beta-1,3(4)-glucanase, pyrimethanil, boscalid, abamectin, dodine, chitosan, copper sulfate, chitosan hydrochloride, COS-OGA, onion extract, nettle extract, mustard extract, horsetail extract, silicic acid, willow extract, swinglea glutinosa extract, fructose, sucrose, sodium hydrogen carbonate, calcium hydroxide, magnesium hydroxide, sunflower oil, maize oil, soyabean oil, onion oil, lecithin, neem oil, activated charcoal, bentonite, thymol, carvacrol, eugenol, geraniol, limonene, acetic acid, natamycin, potassium hydrogen bicarbonate, paraffinic oil, aluminium sulfate, fatty acid, garlic extract, a phosphonate or a salt thereof, laminarine and a microorganism, including an extract of a microorganism, selected from a Trichoderma species, a yeast-based substance, a Bacillus species such as B. amyloliquefaciens, a Rhizobium species and any combination thereof.

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