Rapid detection device for embryo implantation in reproductive gynecology

By utilizing the staining principle of HCG antibodies containing dye binding to HCG, combined with a macro camera and intelligent interaction system, the waiting problem of traditional embryo implantation testing has been solved, enabling portable and rapid HCG content detection and remote doctor connection, thus improving the convenience and accuracy of the test.

WO2026102807A1PCT designated stage Publication Date: 2026-05-21SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
Filing Date
2024-11-26
Publication Date
2026-05-21

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Abstract

Disclosed in the present invention is a rapid detection device for embryo implantation in reproductive gynecology, wherein one end of a detector housing is provided with an insertion slot; a bottom light source is provided below an inner side end of the insertion slot, and a magnifying lens is provided above the inner side end of the insertion slot; a macro camera is provided on the upper side of the detector housing; a detection reaction mechanism is provided in the insertion slot; an intelligent interaction system comprises an identification processing module, an operation interaction module, and a remote terminal module; the identification processing module is located in the detector housing, and the identification processing module is electrically connected to the macro camera. In the present invention, HCG in a sample is detected on the basis of a color‑developing principle in which a dye‑labeled HCG antibody binds to HCG, and video data is acquired by means of a macro camera for processing to estimate the amount of HCG, enabling intuitive visualization of the HCG level; moreover, the data is then uploaded by means of an intelligent interaction system, so that users can directly connect and communicate with doctors remotely, eliminating the need to go to a hospital for blood tests and wait for reports. The portable device allows for testing anytime and anywhere, and is thus convenient and time-saving.
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Description

A rapid detection device for embryo implantation in reproductive gynecology Technical Field

[0001] This invention relates to the field of reproductive testing technology, and in particular to a rapid detection device for embryo implantation in gynecological reproductive medicine. Background Technology

[0002] In assisted reproductive technology, embryo implantation is a crucial step, and its success or failure directly affects the pregnancy outcome; whether an embryo has implanted needs to be detected using specialized instruments.

[0003] Traditional methods of detecting embryo implantation using pregnancy tests typically require waiting for a period of time before determining the level of hCG (human chorionic gonadotropin) in urine. This method can only provide a preliminary assessment and cannot directly detect hCG levels. Blood tests, on the other hand, require a visit to the hospital for blood sampling, which also involves waiting and requires a doctor's assessment and appropriate treatment advice, making it very cumbersome. Therefore, this invention proposes a rapid embryo implantation detection device in reproductive gynecology to solve the problems existing in the prior art. Summary of the Invention

[0004] To address the aforementioned problems, the present invention aims to provide a rapid detection device for embryo implantation in reproductive gynecology. This device detects HCG in samples by using an HCG antibody containing a staining agent to bind and stain HCG. It also acquires video data through a macro camera, processes the data, and estimates the amount of HCG, allowing for direct observation of the HCG content. After the data is uploaded by an intelligent interactive system, it can directly communicate remotely with doctors, eliminating the need to go to the hospital for blood tests and wait for reports. The portable device can be used for testing anytime, anywhere, making it convenient and time-saving.

[0005] To achieve the objectives of this invention, the following technical solution is provided: A rapid detection device for embryo implantation in reproductive gynecology, comprising an intelligent detection mechanism, a detection reaction mechanism, and an intelligent interaction system. The intelligent detection mechanism includes a detector housing, a connector slot, a bottom light source, a magnifying lens, and a macro camera. A connector slot is provided at one end of the detector housing. A bottom light source is located below the inner end of the connector slot, and the bottom end of the connector slot has a through-hole structure, within which the bottom light source is installed. A magnifying lens is located above the inner end of the connector slot, and the magnifying lens is also embedded within the through-hole structure. A macro camera is located on the upper side of the detector housing. The macro camera is detachable, and its mounting opening can be sealed with a dust cover after disassembly. A detection reaction mechanism is located in the connector slot. The intelligent interaction system includes an identification processing module, an operation interaction module, and a remote terminal module. The identification processing module is located inside the detector housing and is electrically connected to the macro camera. Data exchange between the identification processing module, the operation interaction module, and the remote terminal module is achieved through wireless communication technology.

[0006] A further improvement is made in that: the detection reaction mechanism includes a plug-in housing, a connecting plate, a reaction coloring plate, an observation hole, and a siphon hole. The plug-in housing is provided in the plug-in slot, and the connecting plate is fixedly provided inside the plug-in housing. One end of the connecting plate is connected to the reaction coloring plate. The plug-in housing on the upper and lower sides of the reaction coloring plate is provided with an observation hole. The end of the plug-in housing away from the observation hole is provided with a siphon hole. The end of the plug-in housing with the siphon hole extends out of the plug-in slot. At the same time, the observation hole faces the magnifying lens and the bottom light source.

[0007] A further improvement is that the connecting plate is provided with a flow channel and the connecting plate is arranged at a downward angle to facilitate the flow of the dripped sample liquid into the reaction coloring plate. The reaction coloring plate has a sandwich structure, and the interior of the sandwich is coated with HCG antibody containing staining agent.

[0008] A further improvement is that a battery is installed inside the other end of the detector housing, and a button switch is installed on the bottom surface of the detector housing, directly opposite the bottom light source, and the button switch is electrically connected to the bottom light source.

[0009] Further improvements include: the identification and processing module acquires the reaction coloring in the detection reaction mechanism based on a macro camera and estimates the HCG content; the operation interaction module is distributed on the user's and doctor's mobile communication devices or computers for question-and-answer communication between the user and the doctor; and the remote terminal module stores and backs up the user's test results and the data used for question-and-answer communication with the doctor in the cloud based on a cloud data platform.

[0010] Further improvements are made in that: the identification processing module includes a video processing submodule, an estimation output submodule, and a data conversion submodule. The video processing submodule is used to process and distinguish the reaction staining video acquired by the macro camera. The estimation output submodule is used to estimate the HCG content based on the number of HCG antibodies and HCG conjugates distinguished in the acquired reaction staining video. The data conversion submodule is used to convert and send the output data.

[0011] Further improvements are made in that: the operation interaction module includes an authentication submodule, a data upload submodule, and a dialogue communication submodule. The authentication submodule is used for user login authentication and doctor registration qualification authentication. The data upload submodule is used to upload the data obtained by the identification and processing module and user information data. The dialogue communication submodule is used to locate the nearest qualified doctor based on the user information data and allow the user to choose to conduct a question-and-answer dialogue.

[0012] Further improvements are made in that: the remote terminal module includes a data caching submodule and an intelligent recommendation submodule. The data caching submodule is used to cache and back up the question-and-answer communication data between the user and the doctor and the uploaded test data. The intelligent recommendation submodule is used to identify the medication plan in the question-and-answer information between the user and the doctor and list the corresponding drug prices of nearby pharmacies and hospitals for the user to choose from and purchase.

[0013] The beneficial effects of this invention are as follows: This invention detects HCG in samples by using HCG antibodies containing staining agents to bind and stain HCG. It also obtains video data through a macro camera, processes the data, and estimates the amount of HCG. The HCG content can be observed intuitively. After the data is uploaded by the intelligent interactive system, it can directly connect and communicate with doctors remotely. There is no need to go to the hospital for blood tests and wait for reports. The portable device can be used for testing anytime and anywhere, which is convenient and time-saving, and provides a fast and convenient detection method for embryo implantation in reproductive gynecology. Attached Figure Description

[0014] Figure 1 is a cross-sectional view of the device of the present invention.

[0015] Figure 2 is a diagram of the intelligent interactive system architecture of the present invention.

[0016] The components include: 1. Detector housing; 2. Connecting slot; 3. Bottom light source; 4. Magnifying lens; 5. Macro camera; 6. Connecting housing; 7. Connecting plate; 8. Reaction coloring plate; 9. Observation hole; 10. Siphon hole; 11. Flow channel; 12. Storage battery; 13. Push button switch. Detailed Implementation

[0017] To enhance understanding of the present invention, the present invention will be further described in detail below with reference to embodiments. These embodiments are only used to explain the present invention and do not constitute a limitation on the scope of protection of the present invention.

[0018] As shown in Figures 1 and 2, this embodiment provides a rapid detection device for embryo implantation in reproductive gynecology, including an intelligent detection mechanism, a detection reaction mechanism, and an intelligent interaction system. The intelligent detection mechanism includes a detector housing 1, a connector slot 2, a bottom light source 3, a magnifying lens 4, and a macro camera 5. One end of the detector housing 1 is provided with a connector slot 2, and the bottom light source 3 is provided below the inner end of the connector slot 2. The bottom end of the inner end of the connector slot has a through-hole structure, and the bottom light source is installed in the through-hole. The magnifying lens 4 is provided above the inner end of the connector slot 2, and the top end of the inner end of the connector slot also has a through-hole structure, and the magnifying lens is embedded in the through-hole. The macro camera 5 is provided on the upper side of the detector housing 1. The macro camera is detachable and can be installed. After disassembly, the installation port can be sealed with a dust cover. The detection reaction mechanism is provided in the connector slot 2. The intelligent interaction system includes an identification processing module, an operation interaction module, and a remote terminal module. The identification processing module is located inside the detector housing 1 and is electrically connected to the macro camera 5. The identification processing module, the operation interaction module, and the remote terminal module all exchange data through wireless communication technology.

[0019] The detection reaction mechanism includes a plug-in housing 6, a connecting plate 7, a reaction coloring plate 8, an observation hole 9, and a siphon hole 10. The plug-in housing 6 is installed in the plug-in slot 2. The connecting plate 7 is fixedly installed inside the plug-in housing 6. One end of the connecting plate 7 is connected to the reaction coloring plate 8. The observation hole 9 is provided on the plug-in housing 6 on the upper and lower sides of the reaction coloring plate 8. The siphon hole 10 is provided on the end of the plug-in housing 6 away from the observation hole 9. The end of the plug-in housing with the siphon hole extends out of the plug-in slot to avoid blocking the siphon hole. At the same time, the observation hole is directly facing the magnifying lens and the bottom light source.

[0020] The connecting plate 7 is provided with a flow channel 11 and is arranged at a downward angle to facilitate the flow of the dripped sample liquid into the reaction coloring plate. The reaction coloring plate 8 has a sandwich structure, and the inside of the sandwich is coated with HCG antibody containing staining agent. When the sample liquid contains HCG, it will bind to the HCG antibody and stain, making it easy to observe.

[0021] A battery 12 is installed inside the other end of the detector housing 1. A push-button switch 13 is installed on the bottom surface of the detector housing 1, directly opposite the bottom light source 3. The push-button switch 13 is electrically connected to the bottom light source 3 and is used to control the switching of the bottom light source.

[0022] The identification and processing module uses a macro camera 5 to acquire the reaction coloring in the detection reaction mechanism and estimate the HCG content. The operation and interaction module is distributed on the user's and doctor's mobile communication devices or computers for question-and-answer communication between the user and the doctor. The remote terminal module stores and backs up the user's test results and the data used for question-and-answer communication with the doctor in the cloud based on the cloud data platform.

[0023] The identification and processing module includes a video processing submodule, an estimation output submodule, and a data conversion submodule. The video processing submodule is used to process and distinguish the reaction staining video acquired by the macro camera 5. Here, the distinction refers to identifying the distribution quantity of HCG after staining. The estimation output submodule is used to estimate the HCG content based on the number of HCG antibodies and HCG conjugates distinguished in the acquired reaction staining video. The data conversion submodule is used to convert and send the output data, and data exchange is performed using wireless transmission technology.

[0024] The interaction module includes an authentication submodule, a data upload submodule, and a dialogue communication submodule. The authentication submodule is used for user login authentication and doctor registration qualification authentication. The data upload submodule is used to upload the data obtained by the identification and processing module and user information data. The dialogue communication submodule is used to locate the nearest qualified doctor based on the user information data and allow the user to choose to conduct a question-and-answer dialogue.

[0025] The remote terminal module includes a data caching submodule and an intelligent recommendation submodule. The data caching submodule is used to cache and back up the Q&A communication data between users and doctors, as well as the uploaded test data. The intelligent recommendation submodule is used to identify medication plans from the Q&A information between users and doctors and list the corresponding drug prices in nearby pharmacies and hospitals for users to choose from and purchase.

[0026] First, the recognition and processing module is electrically connected to the macro camera. The macro camera collects video data and sends it to the recognition and processing module for processing. The recognition and processing module is located on the circuit board of the device. At the same time, the recognition and processing module has a built-in wireless transmission module, which realizes interconnection with the user's mobile phone through wireless transmission technologies such as Bluetooth to achieve data exchange. By operating the interaction module, the data transmitted to the mobile phone is uploaded to the mobile phone's mini-program or APP platform through wireless signal transmission technology. The uploaded data can be viewed by registered doctors on the platform. Registered doctors can leave their opinions and comments for users to judge and choose.

[0027] When a user selects a one-on-one doctor for communication, the remote terminal module automatically caches the communication content data and extracts sensitive drug-related words. After extraction, it uses big data analytics to locate and search for nearby pharmacies or hospitals where the drug can be purchased, and displays the price for the user to choose from.

[0028] Regarding the estimation of HCG content, since the amount of sample liquid entering the reaction staining plate is fixed, and the field of view obtained by the macro camera is also fixed, the HCG content in the sample liquid within the field of view is calculated by the number of stained HCG antibodies and HCG conjugates within the field of view of the macro camera, thereby determining embryo implantation. The specific calculation method is to divide the number of stained conjugates within the field of view by the volume of the sample liquid within the field of view to obtain the proportion, thus obtaining the HCG content value.

[0029] The foregoing has shown and described the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of the invention. Various changes and modifications can be made to the invention without departing from its spirit and scope, and all such changes and modifications fall within the scope of the present invention as claimed. The scope of protection of the present invention is defined by the appended claims and their equivalents.

Claims

1. A rapid detection device for embryo implantation in reproductive gynecology, characterized in that: The system includes an intelligent detection mechanism, a detection reaction mechanism, and an intelligent interactive system. The intelligent detection mechanism includes a detector housing (1), a connector slot (2), a bottom light source (3), a magnifying lens (4), and a macro camera (5). One end of the detector housing (1) is provided with a connector slot (2). The bottom light source (3) is provided below the inner end of the connector slot (2). The magnifying lens (4) is provided above the inner end of the connector slot (2). The macro camera (5) is provided on the upper side of the detector housing (1). The detection reaction mechanism is provided in the connector slot (2). The intelligent interactive system includes an identification processing module, an operation interactive module, and a remote terminal module. The identification processing module is located inside the detector housing (1) and is electrically connected to the macro camera (5).

2. The rapid detection device for embryo implantation in reproductive gynecology according to claim 1, characterized in that: The detection reaction mechanism includes a plug-in housing (6), a connecting plate (7), a reaction coloring plate (8), an observation hole (9), and a siphon hole (10). The plug-in slot (2) is provided with a plug-in housing (6), and the plug-in housing (6) is provided with a connecting plate (7). One end of the connecting plate (7) is connected to the reaction coloring plate (8). The plug-in housing (6) on the upper and lower sides of the reaction coloring plate (8) is provided with an observation hole (9), and the plug-in housing (6) at the end away from the observation hole (9) is provided with a siphon hole (10).

3. The rapid detection device for embryo implantation in reproductive gynecology according to claim 2, characterized in that: The connecting plate (7) is provided with a flow channel (11) and the connecting plate (7) is arranged at a downward angle. The reaction coloring plate (8) is a sandwich structure, and the interior of the sandwich is coated with HCG antibody containing dye.

4. The rapid detection device for embryo implantation in reproductive gynecology according to claim 1, characterized in that: The detector housing (1) has a battery (12) inside the other end. A button switch (13) is provided on the bottom surface of the detector housing (1) opposite to the bottom light source (3). The button switch (13) is electrically connected to the bottom light source (3).

5. The rapid detection device for embryo implantation in reproductive gynecology according to claim 1, characterized in that: The identification and processing module acquires the reaction coloring in the detection reaction mechanism based on the macro camera (5) and estimates the HCG content. The operation interaction module is distributed on the mobile communication devices or computers of users and doctors and is used for question-and-answer communication between users and doctors. The remote terminal module performs cloud storage and backup of user detection results and data used for question-and-answer communication between users and doctors based on the cloud data platform.

6. The rapid detection device for embryo implantation in reproductive gynecology according to claim 1, characterized in that: The identification processing module includes a video processing submodule, an estimation output submodule, and a data conversion submodule. The video processing submodule is used to process and distinguish the reaction staining video acquired by the macro camera (5). The estimation output submodule is used to estimate the HCG content based on the number of HCG antibodies and HCG conjugates distinguished in the acquired reaction staining video. The data conversion submodule is used to convert and send the output data.

7. The rapid detection device for embryo implantation in reproductive gynecology according to claim 1, characterized in that: The operation interaction module includes an authentication submodule, a data upload submodule, and a dialogue communication submodule. The authentication submodule is used for user login authentication and doctor registration qualification authentication. The data upload submodule is used to upload the data obtained by the identification and processing module and user information data. The dialogue communication submodule is used to locate the nearest qualified doctor based on the user information data and allow the user to choose to conduct a question-and-answer dialogue.

8. The rapid detection device for embryo implantation in reproductive gynecology according to claim 1, characterized in that: The remote terminal module includes a data caching submodule and an intelligent recommendation submodule. The data caching submodule is used to cache and back up the question-and-answer communication data between the user and the doctor, as well as the uploaded test data. The intelligent recommendation submodule is used to identify medication plans from the question-and-answer information between the user and the doctor and to list the corresponding drug prices of nearby pharmacies and hospitals for the user to choose from and purchase.