Cholinesterase inhibitor having function of alleviating neuroinflammation and use thereof
By developing pyranone compounds to inhibit cholinesterase activity and improve neuroinflammation, the problems of cognitive impairment and neuroinflammation in existing treatments for Alzheimer's disease have been solved, achieving an effective treatment for Alzheimer's disease.
WO2026112879A1PCT designated stage Publication Date: 2026-06-04FUJIAN MEDICAL UNIV
Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- FUJIAN MEDICAL UNIV
- Filing Date
- 2024-11-28
- Publication Date
- 2026-06-04
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Figure CN2024135221_04062026_PF_FP_ABST
Abstract
The present invention provides a pyranone compound represented by formula (I). The pyranone compound has excellent anti-inflammatory activity and cholinesterase inhibitory activity, features a high blood-brain barrier penetration potential and good safety, and can ameliorate cognitive impairment related to Alzheimer's disease, reduce glial cell activation, decrease Aβ deposition and alleviate neuroinflammation.
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