Oral care products and compositions thereof

Abstract

Oral care compositions adapted for being dispensed with a pump as well as oral care products comprising an oral care composition and having a pump to dispense such oral care composition are disclosed herein. In accordance with one aspect, provided is an oral care product comprising a container comprising a body defining a chamber and a pump, the pump extending into the chamber of the body; an oral care composition disposed in the chamber, the oral care composition comprising: from about 36 to about 72 wt.% of a polyol system; a thickening system comprising from about 0.4 to about 2.6 wt.% of a silica thickener, a natural gum, and a cellulose; one or more surfactant; and from about 10 to about 36 wt.% of water, wherein all weight percentages are based on the total weight of the oral care composition.

Description

Docket No. 1094755-00- WO-Ol-OCORAL CARE PRODUCTS AND COMPOSITIONS THEREOFCROSS-REFERENCE TO RELATED APPLICATION

[0001] This application claims the benefit of priority from Chinese Patent Application No. 202411729623.2, titled ORAL CARE PRODUCTS AND COMPOSITIONS THEREOF, which was filed on November 28, 2024, the content of which is hereby incorporated herein by reference in their entirety.BACKGROUND

[0002] Many toothpaste products in the market are packaged in a flexible tube. While many consumers are content with toothpaste products packaged in a flexible tube, such toothpaste products may exhibit certain disadvantages including being difficult for some users to squeeze, being difficult for young users to control the amount of toothpaste being dispensed, and the appearance of the deformed toothpaste tube may not be attractive to the user. Also, such toothpaste products often require opening and closing of the cap when used, which may be inconvenient for young children to use.BRIEF SUMMARY

[0003] This summary is intended merely to introduce a simplified summary of some aspects of one or more implementations of the present disclosure. Further areas of applicability of the present disclosure will become apparent from the detailed description provided hereinafter. This summary is not an extensive overview, nor is it intended to identify key or critical elements of the present teachings, nor to delineate the scope of the disclosure. Rather, its purpose is merely to present one or more concepts in simplified form as a prelude to the detailed description below.

[0004] Aspects of the invention are directed to oral care compositions adapted for being dispensed with a pump as well as oral care products comprising an oral care composition and a pump for dispensing such oral care composition. In accordance with an aspect of the invention, provided is an oral care product comprising a container comprising a body defining a chamber and a pump, the pump extending into the chamber of the body; and an oral care composition disposed in the chamber, the oral care composition comprising: from about 36 to about 72 wt.% of a polyol system; a thickening system comprising from about 0.4 to about 2.6 wt.% of a silica thickener, a naturalDocket No. 1094755-00- WO-OLOC gum, and a cellulose; one or more surfactant; and from about 10 to about 36 wt.% of water, wherein all weight percentages are based on the total weight of the oral care composition.

[0005] According to another aspect, provided is an oral care product comprising: a container comprising a body defining a chamber and a pump, the pump extending into the chamber of the body; and an oral care composition disposed in the chamber, the oral care composition comprising: from about 41 to about 67 wt.% of a polyol; a thickening system consisting of from about 0.4 to about 2.6 wt.% of a silica thickener, xanthan gum, and carboxymethyl cellulose, wherein the xanthan gum and the carboxymethyl cellulose are present in a weight ratio of about 10:1 to about 2: 1; and one or more surfactant comprising a betaine surfactant; and from about 13 to about 26 wt.% of water, wherein all weight percentages are based on the total weight of the oral care composition.

[0006] In accordance with a further aspect, provided is an oral care composition adapted for being dispensed using a pump, the oral care composition comprising from about 36 to about 72 wt.% of a polyol system; a thickening system comprising from about 0.4 to about 2.6 wt.% of a silica thickener, a natural gum, and a cellulose; one or more surfactant; and from about 10 to about 36 wt.% of water, wherein all weight percentages are based on the total weight of the oral care composition.

[0007] According to yet an additional aspect, provided is an oral care composition for the use in an oral care product having a pump to reduce clogging within such pump, the oral care composition comprising: from about 36 to about 72 wt.% of a polyol system; a thickening system comprising from about 0.4 to about 2.6 wt.% of a silica thickener, a natural gum, and a cellulose; one or more surfactant; and from about 10 to about 36 wt.% of water, wherein all weight percentages are based on the total weight of the oral care composition. Preferably, the oral care compositions disclosed herein have an instability index of 0.04 or less, more preferably about 0.025 or less, more preferably about 0.02 or less, as measured according to a Lumisizer test. The Lumisizer analytical centrifuge test (referred to herein also as a “Lumisizer test”) is a test method that aims to predict gravity-driven separation of toothpaste formula within its intended shelf life. In general, the instability index of 0.05 or less suggests a shelf life of at least 2 years.

[0008] A non-limiting list of embodiments in accordance with aspects of the invention is provided below:Docket No. 1094755-00- WO-Ol-OC

[0009] In accordance with an embodiment 1 , provided is an oral care product comprising: a container comprising a body defining a chamber and a pump, the pump extending into the chamber of the body; an oral care composition disposed in the chamber, the oral care composition comprising: from about 36 to about 72 wt.% of a polyol system; a thickening system comprising: from about 0.4 to about 2.6 wt.% of a silica thickener, a natural gum, and a cellulose; one or more surfactant; and from about 10 to about 36 wt.% of water, wherein all weight percentages are based on the total weight of the oral care composition.

[0010] In accordance with an embodiment 2, provided is the oral care product according to embodiment 1, wherein the oral care composition has an instability index of 0.04 or less, as measured according to a Lumisizer test.

[0011] In accordance with an embodiment 3, provided is the oral care product according to embodiment 1 or embodiment 2, wherein the silica thickener is present in an amount from about 0.7 to about 2.2 wt.% of thickening silica.

[0012] In accordance with an embodiment 4, provided is the oral care product according to any foregoing embodiment, wherein the silica thickener is present in an amount from about 1 to about 2 wt.% of thickening silica.

[0013] In accordance with an embodiment 5, provided is the oral care product according to any foregoing embodiment, wherein the natural gum is selected from the group consisting of gum arabic, tragacanth gum, karaya gum, agarose, guar gum, pechtin, gellan gum, tara gum, locust bean gum, tamarind gum, locust bean gum, Seneca gum, sclerotium gum, gellan gum, xanthan gum, and a combination of two or more thereof.

[0014] In accordance with an embodiment 6. provided is the oral care product according to any foregoing embodiment, wherein the natural gum comprises xanthan gum.

[0015] In accordance with an embodiment 7, provided is the oral care product according to any foregoing embodiment, wherein the cellulose is selected from the group consisting of from carboxymethylcellulose, ethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, methylhydroxyethylcellulose, and a combination of two or more thereof.

[0016] In accordance with an embodiment 8, provided is the oral care product according to any foregoing embodiment, wherein the cellulose comprises a carboxymethyl cellulose.Docket No. 1094755-00- WO-Ol-OC

[0017] In accordance with an embodiment 9, provided is the oral care product according to any foregoing embodiment, wherein the xanthan gum and the carboxymethyl cellulose are present in a weight ratio of about 10:1 to about 2:1.

[0018] In accordance with an embodiment 10, provided is the oral care product according to any foregoing embodiment, wherein the one or more surfactant is selected from an anionic surfactant, an amphoteric surfactant, and a combination of two or more thereof.

[0019] In accordance with an embodiment 11, provided is the oral care product according to embodiment 10, wherein the anionic surfactant comprises sodium lauryl sulfate, sodium lauryl ether sulfate, ammonium lauryl sulfate, ammonium lauryl ether sulfate, sodium dodecyl sulfate, sodium coco-sulfate, ammonium coco-sulfate, or a combination thereof.

[0020] In accordance with an embodiment 12, provided is the oral care product according to embodiment 10 or embodiment 11, wherein the amphoteric surfactant comprises a betaine surfactant.

[0021] In accordance with an embodiment 13, provided is the oral care product according to any foregoing embodiment, wherein the one or more surfactant is selected from the group consisting of cocamidopropyl betaine, lauryl dimethyl betaine, cetyl dimethyl betaine, cocoamphodiacetate, sodium lauryl sulfate, sodium lauryl ether sulfate, ammonium lauryl sulfate, ammonium lauryl ether sulfate, sodium dodecyl sulfate, sodium coco-sulfate, ammonium coco-sulfate, and a combination of two or more thereof.

[0022] In accordance with an embodiment 14, provided is the oral care product according to any foregoing embodiment, wherein the one or more surfactant is selected from the group consisting of cocamidopropyl betaine, sodium lauryl sulfate, sodium lauryl ether sulfate, and a combination of two or more thereof.

[0023] In accordance with an embodiment 15, provided is the oral care product according to any foregoing embodiment, wherein the polyol system comprises glycerin.

[0024] In accordance with an embodiment 16, provided is the oral care product according to any foregoing embodiment, wherein glycerin comprises about 82 wt.% or more of the polyol system, based on the total weight of the polyols in the oral care composition.

[0025] In accordance with an embodiment 17, provided is the oral care product according to any foregoing embodiment, wherein the oral care composition is substantially free of or free of sorbitol.Docket No. 1094755-00- WO-Ol-OC

[0026] In accordance with an embodiment 18, provided is the oral care product according to any foregoing embodiment, wherein the polyol system consisting of glycerin, a polyethylene glycol, and a combination thereof.

[0027] In accordance with an embodiment 19, provided is the oral care product according to any foregoing embodiment, wherein thickening system is present in a total amount of about 1 to about 5 wt.%.

[0028] In accordance with an embodiment 20, provided is the oral care product according to any foregoing embodiment, wherein the pump comprises a dip tube having a cross-sectional diameter of about 5 to about 15 mm.

[0029] In accordance with an embodiment 21, provided is the oral care product according to any foregoing embodiment, wherein the pump comprises a nozzle having a nozzle length of about 7 to about 25 mm.

[0030] In accordance with an embodiment 22, provided is the oral care product according to any foregoing embodiment, wherein the smallest cross-sectional area of the nozzle is about 4 to about 10 mm2.

[0031] In accordance with an embodiment 23, provided is an oral care product comprising: a container comprising a body defining a chamber and a pump, the pump extending into the chamber of the body; an oral care composition disposed in the chamber, the oral care composition comprising: from about 41 to about 67 wt.% of a polyol; a thickening system consisting of: from about 0.4 to about 2.6 wt.% of a silica thickener, xanthan gum, and carboxymethyl cellulose, wherein the xanthan gum and the carboxymethyl cellulose are present in a weight ratio of about 10: 1 to about 2: 1; one or more surfactant comprising a betaine surfactant; and from about 13 to about 23 wt.% of water, wherein all weight percentages are based on the total weight of the oral care composition.

[0032] In accordance with an embodiment 24, provided is an oral care composition adapted for being dispensed using a pump, the oral care composition comprising: from about 36 to about 72 wt.% of a polyol system; a thickening system comprising: from about 0.4 to about 2.6 wt.% of a silica thickener, a natural gum, and a cellulose; one or more surfactant; and from about 10 to about 36 wt.% of water, wherein all weight percentages are based on the total weight of the oral care composition.Docket No. 1094755-00- WO-Ol-OC

[0033] In accordance with an embodiment 25, provided is an oral care composition for use in an oral care product having a pump to reduce clogging within such pump, the oral care composition comprising: from about 36 to about 72 wt.% of a polyol system; a thickening system comprising: from about 0.4 to about 2.6 wt.% of a silica thickener, a natural gum, and a cellulose; one or more surfactant; and from about 10 to about 36 wt.% of water, wherein all weight percentages are based on the total weight of the oral care composition.

[0034] In accordance with an embodiment 26, provided is an oral care composition according to embodiment 24 or embodiment 25, wherein the oral care composition has an instability index of 0.04 or less, as measured according to a Lumisizer test.

[0035] In accordance with an embodiment 27, provided is an oral care composition according to any one of embodiment 24 to embodiment 26. wherein the silica thickener is present in an amount from about 0.7 to about 2.2 wt.% of thickening silica.

[0036] In accordance with an embodiment 28, provided is an oral care composition according to any one of embodiment 24 to embodiment 27. wherein the silica thickener is present in an amount from about 1 to about 2 wt.% of thickening silica.

[0037] In accordance with an embodiment 29, provided is an oral care composition according to any one of embodiment 24 to embodiment 28, wherein the natural gum is selected from the group consisting of gum arabic, tragacanth gum, karaya gum, agarose, guar gum, pechtin, gellan gum, tara gum, locust bean gum, tamarind gum. locust bean gum, Seneca gum, sclerotium gum, gellan gum, xanthan gum, and a combination of two or more thereof.

[0038] In accordance with an embodiment 30, provided is an oral care composition according to any one of embodiment 24 to embodiment 29, wherein the natural gum comprises xanthan gum.

[0039] In accordance with an embodiment 31, provided is an oral care composition according to any one of embodiment 24 to embodiment 30, wherein the cellulose is selected from the group consisting of from carboxymethylcellulose, ethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, methylhydroxyethylcellulose (MHEC), and a combination of two or more thereof.

[0040] In accordance with an embodiment 32, provided is an oral care composition according to any one of embodiment 24 to embodiment 31, wherein the cellulose comprises a carboxymethyl cellulose.Docket No. 1094755-00- WO-Ol-OC

[0041] In accordance with an embodiment 33, provided is an oral care composition according to any one of embodiment 24 to embodiment 32, wherein the xanthan gum and the carboxymethyl cellulose are present in a weight ratio of about 10: 1 to about 2:1.

[0042] In accordance with an embodiment 34, provided is an oral care composition according to any one of embodiment 24 to embodiment 33, wherein the one or more surfactant is selected from an anionic surfactant, an amphoteric surfactant, and a combination of two or more thereof.

[0043] In accordance with an embodiment 35, provided is an oral care composition according to embodiment 34, wherein the anionic surfactant comprises sodium lauryl sulfate, sodium lauryl ether sulfate, ammonium lauryl sulfate, ammonium lauryl ether sulfate, sodium dodecyl sulfate, sodium coco-sulfate, ammonium coco-sulfate or a combination thereof.

[0044] In accordance with an embodiment 36, provided is an oral care composition according to embodiment 34 or embodiment 35, wherein the amphoteric surfactant comprises a betaine surfactant.

[0045] In accordance with an embodiment 37, provided is an oral care composition according to any one of embodiment 24 to embodiment 36, wherein the one or more surfactant is selected from the group consisting of cocamidopropyl betaine, lauryl dimethyl betaine, cetyl dimethyl betaine, cocoamphodiacetate, sodium lauryl sulfate, sodium lauryl ether sulfate, ammonium lauryl sulfate, ammonium lauryl ether sulfate, sodium dodecyl sulfate, sodium coco-sulfate, ammonium coco- sulfate, and a combination of two or more thereof.

[0046] In accordance with an embodiment 38, provided is an oral care composition according to any one of embodiment 24 to embodiment 37, wherein the one or more surfactant is selected from the group consisting of cocamidopropyl betaine, sodium lauryl sulfate, sodium lauryl ether sulfate, and a combination of two or more thereof.

[0047] In accordance with an embodiment 39, provided is an oral care composition according to any one of embodiment 24 to embodiment 38. wherein the polyol system comprises glycerin.

[0048] In accordance with an embodiment 40, provided is an oral care composition according to any one of embodiment 24 to embodiment 39, wherein glycerin comprises about 82 wt.% or more of the polyol system, based on the total weight of the polyols in the oral care composition.

[0049] In accordance with an embodiment 41, provided is an oral care composition according to any one of embodiment 24 to embodiment 40, wherein the oral care composition is substantially free of or free of sorbitol.Docket No. 1094755-00- WO-Ol-OC

[0050] In accordance with an embodiment 42, provided is an oral care composition according to any one of embodiment 24 to embodiment 41, wherein the polyol system consisting of glycerin, a polyethylene glycol, and a combination thereof.

[0051] In accordance with an embodiment 43, provided is an oral care composition according to any one of embodiment 24 to embodiment 42, wherein thickening system is present in a total amount of about 1 to about 5 wt.%, based on the total weight of the polyols in the oral care composition.BRIEF DESCRIPTION OF THE DRAWINGS

[0052] Implementation of the present technology will now be described, by way of example only, with reference to the attached figures, wherein:

[0053] FIG. 1 is a schematic of an exemplary, non-limiting oral care product in accordance with aspects of the invention;

[0054] FIG. 2 is a drawing showing a cross section of an exemplary, non-limiting pump in accordance with aspects of the invention; and

[0055] FIG. 3 is a graph showing the instability index for exemplary, non-limiting oral care compositions and comparative oral care compositions in accordance with aspects of the present invention.

[0056] It should be understood that the various aspects are not limited to the arrangements and instrumentality shown in the drawings.DETAILED DESCRIPTION

[0057] For illustrative purposes, the principles of the present invention are described by referencing various exemplary embodiments thereof. Although certain embodiments of the invention are specifically described herein, one of ordinary skill in the art will readily recognize that the same principles are equally applicable to, and can be employed in other compositions and methods. Before explaining the disclosed embodiments of the present invention in detail, it is to be understood that the invention is not limited in its application to the details of any particular embodiment disclosed herein. The terminology used herein is for the purpose of description and not of limitation.Docket No. 1094755-00- WO-Ol-OC

[0058] As used herein and in the appended claims, the singular forms “a”, “an”, and “the” include plural references unless the context dictates otherwise. The singular form of any class of the ingredients refers not only to one chemical species within that class, but also to a mixture of those chemical species. The terms “a” (or “an”), “one or more” and “at least one” may be used interchangeably herein. The terms “comprising”, “including”, and “having” may be used interchangeably. The term “include” should be interpreted as “include, but are not limited to”. The term “including” should be interpreted as “including, but are not limited to”.

[0059] As used throughout, ranges are used as shorthand for describing each and every value that is within the range. Any value within the range can be selected as the terminus of the range. Thus, a range from 1-5, includes specifically 1, 2, 3, 4 and 5, as well as subranges such as 2-5, 3-5, 2-3, 2-4, 1-4, etc.

[0060] The term “about” when referring to a number means any number within a range of 10% of the number. For example, the phrase “about 2 wt.%” refers to a number between and including 1.8 wt.% and 2.2 wt.%.

[0061] All references cited herein are hereby incorporated by reference in their entireties. In the event of a conflict in a definition in the present disclosure and that of a cited reference, the present disclosure controls.

[0062] The abbreviations and symbols as used herein, unless indicated otherwise, take their ordinary meaning. The abbreviation “wt.%” means percent by weight with respect to the oral care composition. The symbol “°” refers to a degree, such as a temperature degree or a degree of an angle. The symbols “h”, “min”, “mL”, “nm”, and “pm” refer to hour, minute, milliliter, nanometer, and micrometer, respectively. The abbreviation “UV-VIS” referring to a spectrometer or spectroscopy, means Ultraviolet- Visible. The abbreviation “rpm” means revolutions per minute.

[0063] When referring to chemical structures, and names, the symbols “C”, “H”, and “O” mean carbon, hydrogen, and oxygen, respectively. The symbols“=” and “=” mean single bond, double bond, and triple bond, respectively.

[0064] “Volatile”, as used herein, means having a flash point of less than about 100° C. “Nonvolatile”, as used herein, means having a flash point of greater than about 100° C.

[0065] Any member in a list of species that are used to exemplify or define a genus, may be mutually different from, or overlapping with, or a subset of. or equivalent to, or nearly the same as, or identical to, any other member of the list of species. Further, unless explicitly stated, such asDocket No. 1094755-00- WO-OLOC when reciting a Markush group, the list of species that define or exemplify the genus is open, and it is given that other species may exist that define or exemplify the genus just as well as, or better than, any other species listed.

[0066] The phrases, “a mixture thereof,” “a combination thereof,” or a combination of two or more thereof’ do not require that the mixture include all of A, B, C, D, E, and F (although all of A, B,C. D, E, and F may be included). Rather, it indicates that a mixture of any two or more of A, B, C,D, E, and F can be included. In other words, it is equivalent to the phrase “one or more elements selected from the group consisting of A, B, C. D, E, F, and a mixture of any two or more of A, B, C, D, E, and F.” Likewise, the term “a salt thereof’ also relates to “salts thereof.” Thus, where the disclosure refers to “an element selected from the group consisting of A, B, C, D, E, F, a salt thereof, and a mixture thereof,” it indicates that that one or more of A, B, C, D, and F may be included, one or more of a salt of A, a salt of B, a salt of C, a salt of D, a salt of E, and a salt of F may be included, or a mixture of any two of A, B, C, D, E, F, a salt of A, a salt of B, a salt of C, a salt of D, a salt of E, and a salt of F may be included.

[0067] All components and elements positively set forth in this disclosure can be negatively excluded from the claims. In other words, the oral care compositions of the instant disclosure can be free or essentially free of all components and elements positively recited throughout the instant disclosure. In some instances, the oral care compositions of the present disclosure may be substantially free of non-incidental amounts of the ingredient(s) or compound(s) described herein. A non-incidental amount of an ingredient or compound is the amount of that ingredient or compound that is added into the oral care composition by itself. For example, an oral care composition may be substantially free of a non-incidental amount of an ingredient or compound, although such ingredient(s) or compound(s) may be present as part of a raw material that is included as a blend of two or more compounds.

[0068] Some of the various categories of components identified may overlap. In such cases where overlap may exist and the oral care composition includes both components (or the composition includes more than two components that overlap), an overlapping compound does not represent more than one component. For example, certain compounds may be characterized as both a polyol source and a sweetener. If a particular oral care composition recites both a polyol and a sweetener, xylitol will serve only as either a polyol or a sweetener — not both.Docket No. 1094755-00- WO-Ol-OC

[0069] For readability purposes, the chemical functional groups are in their adjective form; for each of the adjectives, the word “group” is assumed. For example, the adjective “alkyl” without a noun thereafter, should be read as “an alkyl group.”

[0070] Aspects of the invention are directed to oral care compositions adapted for being dispensed with a pump as well as oral care products comprising an oral care composition and having a pump to dispense such oral care composition. Formulating oral care compositions for use with a pump (e.g., a lotion pump) is challenging as drying out or clogging in the nozzle of the pump, balancing the viscosity and pumpability of the oral care composition, and maintaining oral care efficacy are challenges. The inventors discovered that the problem of drying out or clogging in the nozzle of a pump can be overcome utilizing certain oral care compositions specifically adapted for dispensing with a pump. For instance, the inventors discovered that oral care compositions having particular polyol systems, thickening systems, and certain surfactants achieve a preferred instability index of 0.04 or less, more preferably about 0.025 or less, more preferably about 0.02 or less, as measured according to a Lumisizer test, which is indicative of a reduction in clogging and / or drying out in the nozzle of a pump, while simultaneously achieving desirable pumping viscosity and pumpability.

[0071] In accordance with an aspect of the invention, provided is an oral care product comprising a container comprising a body defining a chamber and a pump, the pump extending into the chamber of the body; and an oral care composition disposed in the chamber, the oral care composition comprising: from about 36 to about 72 wt.% of a polyol system; a thickening system comprising from about 0.4 to about 2.6 wt.% of a silica thickener, a natural gum, and a cellulose; one or more surfactant; and from about 10 to about 36 wt.% of water, wherein all weight percentages are based on the total weight of the oral care composition.

[0072] According to another aspect, provided is an oral care product comprising: a container comprising a body defining a chamber and a pump, the pump extending into the chamber of the body; an oral care composition disposed in the chamber, the oral care composition comprising: from about 41 to about 67 wt.% of a polyol; a thickening system consisting of from about 0.4 to about 2.6 wt.% of a silica thickener, xanthan gum, and carboxymethyl cellulose, wherein the xanthan gum and the carboxymethyl cellulose are present in a weight ratio of about 10:1 to about 2: 1; and one or more surfactant comprising a betaine surfactant; and from about 13 to about 36Docket No. 1094755-00- WO-Ol-OC wt.% of water, wherein all weight percentages are based on the total weight of the oral care composition.

[0073] In accordance with a further aspect, provided is an oral care composition adapted for being dispensed using a pump, the oral care composition comprising from about 36 to about 72 wt.% of a polyol system; a thickening system comprising from about 0.4 to about 2.6 wt.% of a silica thickener, a natural gum, and a cellulose; one or more surfactant; and from about 10 to about 36 wt.% of water, wherein all weight percentages are based on the total weight of the oral care composition. Preferably, the oral care composition has an instability index of 0.04 or less, more preferably about 0.025 or less, more preferably about 0.02 or less, e.g., as measured according to a Lumisizer test. In further preferred embodiments, the oral care compositions have a pumping viscosity of 2.5 to 4.5, preferably 2.8 to 4.2, or preferably 3 to 4.2. Additionally, or alternatively, the oral care compositions may, preferably, have a pumping force of 30 to 45 or about 35 to about 43. In some preferred embodiments, the oral care compositions have a yield stress of 30 to 40, preferably about 35 to about 38.

[0074] According to yet an additional aspect, provided is an oral care composition for the use in an oral care product having a pump to reduce clogging within such pump, the oral care composition comprising: from about 36 to about 72 wt.% of a polyol system; a thickening system comprising from about 0.4 to about 2.6 wt.% of a silica thickener, a natural gum, and a cellulose; one or more surfactant; and from about 10 to about 36 wt.% of water, wherein all weight percentages are based on the total weight of the oral care composition.

[0075] The oral care product typically comprises a container comprising a body defining a chamber. In addition to the container, the oral care products typically comprise a pump. With reference to FIGS. 1 and 2, the container 100 typically comprises a body 110 and a pump 120. The body 110 defines a chamber adapted for containing an oral care composition. Pump 120 typically extends into the chamber defined by body 110.

[0076] Referring to Fig. 2, pump 120 may comprise a nozzle head 122, a plunger 124, a container cap 126, a sheath 128, a spring 130, an engine 132, a dip tube 134, and a PE 136. Pump 120 may have a dip tube 134 configured to extend into the chamber of body 110 when pump 120 is coupled to body 110. Pump 120 may be configured such that actuating pump 120 by pressing nozzle head 122 in a direction toward sheath 128 compress the spring 130 and then activates engine 132. Actuating pump 120 may create a suction that draws an oral care composition into and throughDocket No. 1094755-00- WO-Ol-OC dip tube 134. The oral care composition may then be biased through nozzle head 122 to be dispensed out of the opening of nozzle head 122. One of ordinary skill would readily understand the operations of pump 120. Additional description for pumps and components thereof that may be suitable for some embodiments of the oral care products disclosed herein can be found in U.S. Patent No. 8,231,031, U.S. Patent Publication No. 2010 / 230,443, and U.S. Patent Publication No. 2021 / 229,123, which are all incorporated herein by reference in their entirety for all purposes.

[0077] Preferably, dip tube 134 may have a cross-sectional diameter Di of about 5 to about 15 mm. In some embodiments, the cross-sectional diameter Di of dip tube 134 is about 5 to about 12 mm, about 5 to about 10 mm, about 5 to about 8 mm, about 6 to about 8 mm, about 7 to about 8 mm, or any range or subrange thereof. Pump 120 may have a nozzle length Li of about 7 to about 25 mm. In some embodiments, the nozzle length Li of the nozzle head 122 is about 7 to about 20 mm, about 7 to about 16 mm, about 7 to about 14 mm, about 10 to about 14 mm, about 12 to about 14 mm, or any range or subrange thereof.

[0078] The pump 120 may have a nozzle head 122 has a passageway having a smallest cross- sectional area of about 4 to about 10 mm2. In some embodiments, the smallest cross-sectional area within the passageway of the nozzle head 122 may be about 4 to about 10 mm2, about 4 to about 8 mm2, about 4 to about 6 mm2, about 6 to about 10 mm2, about 8 to about 10 mm2, about 5 to about 7 mm2, or any range or subrange thereof. Without being limited to any particular theory, it is believed that the problems of drying out of the oral care composition and / or clogging in the nozzle head 122 may occur or cause issues at the smallest cross-sectional area. As discussed herein, embodiments of the oral care compositions disclosed herein may advantageously avoid drying out and / or clogging in the nozzle head 120.

[0079] The oral care compositions may be in the form of dentifrice, toothpaste, gels, and / or the like. Suitable components, such as those listed below, may be included or excluded from the formulations for the oral care compositions depending on the specific combination of other ingredients and the form of the oral care compositions. Additionally or alternatively, the oral care compositions may in some embodiments have a single phase, which contains that components and / or ingredients of the oral care composition. In other embodiments, the oral care composition may include two or more phases, such as two, three, four, or five phases.

[0080] The oral care composition typically includes a polyol system in an amount from about 36 to about 72 wt.%, based on the total weight of the oral care composition. For example, the totalDocket No. 1094755-00- WO-Ol-OC amount of the polyol system present in the oral care composition may be from about 41 to about 72 wt.%, about 44 to about 72 wt.%, about 47 to about 72 wt.%, about 50 to about 72 wt.%, about 53 to about 72 wt.%, about 57 to about 72 wt.%; from about 36 to about 67 wt.%, about 41 to about 67 wt.%, about 44 to about 67 wt.%, about 47 to about 67 wt.%, about 50 to about 67 wt.%, about 53 to about 67 wt.%, about 57 to about 67 wt.%; from about 36 to about 62 wt.%, about 41 to about 62 wt.%. about 44 to about 62 wt.%, about 47 to about 62 wt.%, about 50 to about 62 wt.%, about 53 to about 62 wt.%, about 57 to about 62 wt.%; from about 36 to about 58 wt.%, about 41 to about 58 wt.%, about 44 to about 58 wt.%, about 47 to about 58 wt.%, about 50 to about 58 wt.%, about 53 to about 58 wt.%; from about 36 to about 54 wt.%, about 41 to about 54 wt.%, about 44 to about 54 wt.%, about 47 to about 54 wt.%, about 50 to about 54 wt.%; from about 36 to about 50 wt.%. about 41 to about 50 wt.%, about 44 to about 50 wt.%, about 47 to about 50 wt.%; from about 36 to about 47 wt.%, about 41 to about 47 wt.%, or any range or subrange thereof, based on the total weight of the oral care composition.

[0081] The polyol system may be chosen from glycols or compounds with numerous hydroxyl groups, such as glycerin. The one or more polyols may be liquid at ambient temperature (25°C). The polyol may be a humectant. In some cases, the oral care composition includes one or more polyol selected from the group consisting of C2-C32 polyols. The one or more polyols may have from 2 to 32 carbon atoms, from 3 to 16 carbon atoms, or from 3 to 12 carbon atoms. For example, the oral care composition may comprise ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, glycerin, diglycerin, diethylene glycol, dipropylene glycol, polyethylene glycol or a combination of two or more thereof. In certain embodiments, the polyol comprises one or more glycols, such as those selected from propylene glycol, ethylene glycol, butylene glycol, capryl glycol, polyethylene glycol, or a combination of two or more thereof.

[0082] The oral care compositions preferably have a reduced amount, are substantially free of, or are free of sorbitol. In some preferred embodiments, the oral care composition has about 3 wt.% or less, about 2 wt.% or less, about 1 wt.% or less, about 0.5 wt.% or less, about 0.1 wt.% or less, or about 0.01 wt.% or less of sorbitol, based on the total weight of the oral care composition. The oral care composition may desirably have 0 wt.% of sorbitol, based on the total weight of the oral care composition.

[0083] Preferably, the oral care composition comprises glycerin. For instance, in some preferred embodiments, the oral care composition has glycerin in an amount comprising about 82 or moreDocket No. 1094755-00- WO-Ol-OC of the polyol system, based on the total weight of the polyols in the oral care composition. In some preferred embodiments, the glycerin comprises about 85 or more, about 88 or more, about 91 or more, about 93 or more, or about 96 or more, of the polyol system, based on the total weight of the polyols in the oral care composition. In at least one embodiment, glycerin is the sole polyol in the oral care composition. In another embodiment, the polyol system comprises glycerin and a polyethylene glycol, such as polyethylene glycol 400. polyethylene glycol 600. or polyethylene glycol 800.

[0084] In addition to the polyol system, the oral care compositions adapted for being dispensed with a pump typically comprise a thickening system having a silica thickener, a natural gum, and a cellulose. The thickening system may be present in a total amount of about 1 to about 5 wt.%, based on the total weight of the oral care composition. For example, the total amount of the thickening system may be from about 1 to about 4 wt.%, about 1 to about 3 wt.%, about 1 to about 2.6 wt.%, about 1 to about 2.2 wt.%, about 1 to about 2 wt.%; from about 1.5 to about 5 wt.%, about 1.5 to about 4 wt.%, about 1.5 to about 3 wt.%, about 1.5 to about 2.6 wt.%; from about 2 to about 5 wt.%, about 2 to about 4 wt.%, about 2 to about 3 wt.%; from about 2.5 to about 5 wt.%, about 2.5 to about 4 wt.%, or any range or subrange thereof, based on the total weight of the oral care composition.

[0085] The silica thickener may be present in the oral care composition in amount from about 0.4 to about 2.6 wt.%, based on the total weight of the oral care composition. In some preferred embodiments, the silica thickener is present in an amount from about 0.4 to about 2.3 wt.%, about 0.4 to about 2 wt.%, about 0.4 to about 1.7 wt.%, about 0.4 to about 1.4 wt.%; from about 0.7 to about 2.6 wt.%, about 0.7 to about 2.3 wt.%. about 0.7 to about 2 wt.%, about 0.7 to about 1.7 wt.%, about 0.7 to about 1.4 wt.%; from about 1 to about 2.6 wt.%, about 1 to about 2.3 wt.%, about 1 to about 2 wt.%, about 1 to about 1.7 wt.%, about 1 to about 1.4 wt.%; from about 1.4 to about 2.6 wt.%, about 1.4 to about 2.3 wt.%, about 1.4 to about 2 wt.%; from about 1.7 to about 2.6 wt.%, about 1.7 to about 2.3 wt.%; from about 2 to about 2.6 wt.%, or any range or subrange thereof, based on the total weight of the oral care composition.

[0086] The thickening silica, sometimes referred to as silica thickeners, typically form polymeric structures or gels in aqueous media. The thickening silica is typically physically and functionally distinct from the particulate silica abrasives as the silica thickeners are very finely divided and provide little or no abrasive action.Docket No. 1094755-00- WO-OLOC

[0087] The thickening system may include a thickening silica having a particle size distribution (D95) less than or equal to 7 pm and a BET surface area of greater than or equal to 150 m2 / g. In some cases, the thickening silica has a BET surface area of greater than or equal to 175 m2 / g, greater than or equal to 200 m2 / g, or greater than or equal to 250 m2 / g. For example, the thickening silica may have a BET surface area of about 150 to about 350 m2 / g, about 170 to about 350 m2 / g, about 190 to about 350 m2 / g, about 210 to about 350 m2 / g, about 230 to about 350 m2 / g, about 250 to about 350 m2 / g, about 270 to about 350 m2 / g, about 290 to about 350 m2 / g, about 310 to about 350 m2 / g, about 330 to about 350 m2 / g; from about 150 to about 300 m2 / g, about 170 to about 300 m2 / g, about 190 to about 300 m2 / g, about 210 to about 300 m2 / g, about 230 to about 300 m2 / g, about 250 to about 300 m2 / g, about 270 to about 300 m2 / g; from about 150 to about 275 m2 / g, about 170 to about 275 m2 / g, about 190 to about 275 m2 / g, about 210 to about 275 m2 / g, about 230 to about 275 m2 / g, about 250 to about 275 m2 / g; from about 150 to about 250 m2 / g, about 170 to about 250 m2 / g, about 190 to about 250 m2 / g, about 210 to about 250 m2 / g, about 230 to about 250 m2 / g; from about 150 to about 225 m2 / g, about 170 to about 225 m2 / g, about 190 to about 225 m2 / g, about 210 to about 225 m2 / g, or any range or subrange thereof.

[0088] Additionally or alternatively, the thickening silica may have an oil absorption of greater than or equal to about 200 mL / 100 g, about 240 mL / 100 g, about 250 mL / 100 g, or any range thereof. For instance, the thickening silica may have an oil absorption of about 200 to about 250 mL / 100 g, about 210 to about 250 mL / 100 g. about 220 to about 250 mL / 100 g, about 230 to about 250 mL / 100 g; from about 200 to about 240 mL / 100 g, about 210 to about 240 mL / 100 g, about 220 to about 240 mL / 100 g, about 230 to about 240 mL / 100 g; from about 200 to about 230 mL / 100 g, about 210 to about 230 mL / 100 g. about 220 to about 230 mL / 100 g, or any range or subrange thereof.

[0089] In addition to the silica thickener, the thickener system typically comprises a natural gum and a cellulose. The thickener system may comprise a natural gum in an amount from about 0.2 to about 2 wt.%, based on the total weight of the oral care composition. For example, one or more natural gum may be present in the oral care composition in a total amount of from about 0.2 to about 1.6 wt.%, about 0.2 to about 1.2 wt.%, about 0.2 to about 1 wt.%, about 0.2 to about 0.8 wt.%, about 0.2 to about 0.5 wt.%; from about 0.35 to about 2 wt.%, about 0.35 to about 1.6 wt.%, about 0.35 to about 1.2 wt.%, about 0.35 to about 1 wt.%. about 0.35 to about 0.8 wt.%, about 0.35 to about 0.5 wt.%; from about 0.5 to about 2 wt.%, about 0.5 to about 1.6 wt.%, about 0.5 to aboutDocket No. 1094755-00- WO-Ol-OC1 .2 wt.%, about 0.5 to about 1 wt.%, about 0.5 to about 0.8 wt.%; from about 0.75 to about 2 wt.%, about 0.75 to about 1.6 wt.%, about 0.75 to about 1.2 wt.%, about 0.75 to about 1 wt.%; from about 1 to about 2 wt.%. about 1 to about 1.6 wt.%, or any range or subrange thereof, based on the total weight of the oral care composition.

[0090] Examples of natural gums that may be included in, or in certain embodiments excluded from, the oral care composition include alginate, pectin, carrageenan, gum arabic. tragacanth gum, karaya gum, agarose, guar gum, pechtin, gellan gum, tara gum, locust bean gum, tamarind gum, locust bean gum, Seneca gum, sclerotium gum, gellan gum, xanthan gum, or a combination of two or more thereof. For instance, the thickening system may include a natural gum comprising gum arabic, tragacanth gum, karaya gum, agarose, guar gum, pechtin, gellan gum, tara gum, locust bean gum, tamarind gum, locust bean gum, Seneca gum, sclerotium gum. gellan gum. xanthan gum, or a combination thereof. In some cases, the oral care composition includes a natural gum selected from xanthan gum, carrageenan, pechtin, alginate, pectin, and a combination of two or more thereof. In at least one preferred embodiment, the natural gum comprises or consists of xanthan gum.

[0091] The amount of cellulose in the thickening system may be from about 0.05 to about 1 wt.%, based on the total weight of the oral care composition. In some cases, the total amount of cellulose(s) in the oral care composition is from about 0.05 to about 0.7 wt.%, about 0.05 to about 0.5 wt.%, about 0.05 to about 0.3 wt.%, about 0.05 to about 0.1 wt.%; from about 0.1 to about 1 wt.%, about 0.1 to about 0.7 wt.%, about 0.1 to about 0.5 wt.%, about 0.1 to about 0.3 wt.%; from about 0.3 to about 1 wt.%, about 0.3 to about 0.7 wt.%, about 0.3 to about 0.5 wt.%; from about 0.5 to about 1 wt.%. about 0.5 to about 0.7 wt.%, or any range or subrange thereof, based on the total weight of the oral care composition.

[0092] Examples of celluloses include cellulose ether chosen from carboxymethylcellulose (CMC), ethylcellulose (EC), hydroxypropylcellulose (HPC), hydroxy propylmethylcellulose (HPMC), methylhydroxyethylcellulose (MHEC), a salt thereof, and mixtures thereof. In some embodiments, the cellulose is a modified cellulose selected from microcrystalline cellulose (MCC), e.g., in the anhydrous or hydrated forms thereof, and cellulose ethers such as hydroxypropylcellulose (HPC) and hydroxypropylmethylcellulose (HPMC). In at least one preferred embodiment, the cellulose comprises or consists of carboxymethylcellulose and / or salts thereof.Docket No. 1094755-00- WO-Ol-OC

[0093] Preferably, the thickening system is adapted to have the xanthan gum and the carboxymethyl cellulose present in a weight ratio of about 10:1 to about 2:1. In some preferred embodiments, the weight ratio of the xanthan gum and the carboxymethyl cellulose is from about 8:1 to about 2:1, about 6:1 to about 2:1, about 5: 1 to about 2:1, about 4: 1 to about 2: 1; from about 10: 1 to about 3: 1, about 8:1 to about 3: 1, about 6: 1 to about 3: 1, about 5:1 to about 3: 1; from about 10: 1 to about 4: 1, about 8: 1 to about 4: 1, about 6: 1 to about 4: 1; from about 10: 1 to about 5: 1, about 8: 1 to about 5:1, about 7: 1 to about 5: 1; from about 10:1 to about 6: 1, about 8: 1 to about 6: 1, or any range or subrange thereof.

[0094] The oral care compositions typically comprise one or more surfactant(s). The total amount of surfactants in the oral care composition may be from about 0.5 to about 5 wt.%, based on the total weight of the oral care composition. For example, the oral care composition may include one or more surfactant in an amount from about 0.5 to about 4 wt.%, about 0.5 to about 3 wt.%, about 0.5 to about 2 wt.%, about 0.5 to about 1.5 wt.%; from about 0.75 to about 4 wt.%, about 0.75 to about 3 wt.%, about 0.75 to about 2 wt.%, about 0.75 to about 1.5 wt.%; from about 1 to about 5 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%, about 1 to about 2 wt.%; from about 1.5 to about 5 wt.%, about 1.5 to about 4 wt.%, about 1.5 to about 3 wt.%, about 1.5 to about 2 wt.%; from about 2 to about 5 wt.%, about 2 to about 4 wt.%, about 2 to about 3 wt.%; from about 2.5 to about 5 wt.%, about 2.5 to about 4 wt.%, about 2.5 to about 3.5 wt.%; from about 3 to about 5 wt.%, about 3 to about 4 wt.%, or any range or subrange thereof, based on the total weight of the oral care composition.

[0095] The one or more surfactant may be selected from anionic surfactant(s), amphoteric surfactant(s). and / or combinations of two or more thereof. The one or more surfactant(s) may comprise an anionic surfactant, such as those selected from water-soluble, water-miscible salts of alkyl sulfate, such as those having from 8 to 20 carbon atoms in the alkyl radical (e.g., sodium alkyl sulfate) and the water-soluble or water-miscible salts of sulfonated monoglycerides of fatty acids having from 8 to 20 carbon atoms. Examples of anionic surfactants, which may be included or excluded in some instances from the oral care composition, include sodium lauryl sulfate, sodium lauryl ether sulfate, ammonia lauryl sulfate, ammonia lauryl ether sulfate, sodium lauryl sarcosinate, sodium cocoyl methyl taurate, sodium monoglyceride sulfate, sodium cetaryl sulfate, potassium cocoyl glycinate, sodium lauryl phosphate, sodium lauryl lactylate, sodium lauryl sulfoacetate, sodium lauryl glutamate, sodium lauryl isethionate, sodium laureth carboxylate,Docket No. 1094755-00- WO-Ol-OC sodium dodecyl benzenesulfonate, and combinations thereof. Tn some preferred embodiments, the anionic surfactant comprises or consists of sodium lauryl sulfate, sodium lauryl ether sulfate, ammonium lauryl sulfate, ammonium lauryl ether sulfate, sodium dodecyl sulfate, sodium coco- sulfate, ammonium coco- sulfate, and / or a combination thereof. In at least one embodiment, sodium lauryl sulfate and / or sodium lauryl ether sulfate are preferred surfactants. Additional anionic surfactants are disclosed in U.S. Pat. No. 3,959,458. which is incorporated herein in its entirety for all purposes.

[0096] The amount of anionic surfactant(s) present in the oral care composition may be from about 0.1 to about 5 wt.%, based on the total weight of the oral care composition. In some instances, the oral care composition includes anionic surfactant(s) in an amount from about 0.1 to about 4 wt.%, about 0.1 to about 3 wt.%, about 0.1 to about 2 wt.%, about 0.1 to about 1.5 wt.%, about 0.1 to about 1 wt.%, about 0.1 to about 0.5 wt.%; from about 0.2 to about 4 wt.%, about 0.2 to about 3 wt.%, about 0.2 to about 2 wt.%, about 0.2 to about 1.5 wt.%, about 0.2 to about 1 wt.%, about 0.2 to about 0.5 wt.%; from about 0.5 to about 4 wt.%, about 0.5 to about 3 wt.%, about 0.5 to about 2 wt.%, about 0.5 to about 1.5 wt.%; from about 0.75 to about 4 wt.%, about 0.75 to about 3 wt.%, about 0.75 to about 2 wt.%, about 0.75 to about 1.5 wt.%; from about 1 to about 5 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%, about 1 to about 2 wt.%; from about 1.5 to about 5 wt.%, about 1.5 to about 4 wt.%, about 1.5 to about 3 wt.%, about 1.5 to about 2 wt.%; from about 2 to about 5 wt.%, about 2 to about 4 wt.%. about 2 to about 3 wt.%, or any range or subrange thereof, based on the total weight of the oral care composition.

[0097] The amphoteric surfactants are preferably selected from the group consisting of betaine surfactants. Examples of betaine surfactants include cocamidopropyl betaine, lauryl dimethyl betaine (sold under the trade name Macat LB), cetyl dimethyl betaine, and cocoamphodiacetate. The amphoteric surfactant may comprise a substituent containing 8 to 18 carbon atoms and a substituent containing one or more carboxylate, sulfonate, sulfate, phosphate, or phosphonate. For instance, the amphoteric surfactant may have an alkyl group comprising from 8 to 20 carbon atoms, 8 to 16 carbon atoms, 10 to 16 carbon atoms, or 10 to 13 carbon atoms. The amphoteric surfactant(s) may include, but are not limited to, derivatives of aliphatic secondary and tertiary amines in which the aliphatic radical can be straight chain or branched. In some cases, one of the aliphatic substituents of the amphoteric surfactant contains about 8 to about 18 carbon atoms and one of the aliphatic substituents contains an anionic water solubilizing group, e.g., carboxy,Docket No. 1094755-00- WO-Ol-OC sulfonate, sulfate, phosphate, or phosphonate. The amphoteric surfactants disclosed herein may be present in the oral care composition in a salt form. Additional examples of amphoteric surfactants, which may be included or in some preferred embodiments excludes from the oral care composition, include alkyl sultaines, alkyl amphoacetates, and alkyl amphopropionates. In at least one embodiment, the amphoteric surfactant comprises or consists of cocamidopropyl betaine.

[0098] The amount of amphoteric surfactant(s) present in the oral care composition may be from about 0.1 to about 5 wt.%, based on the total weight of the oral care composition. In some instances, the oral care composition includes anionic surfactant(s) in an amount from about 0.1 to about 4 wt.%, about 0.1 to about 3 wt.%, about 0.1 to about 2 wt.%, about 0.1 to about 1.5 wt.%, about 0.1 to about 1 wt.%, about 0.1 to about 0.5 wt.%; from about 0.3 to about 4 wt.%, about 0.3 to about 3 wt.%, about 0.3 to about 2 wt.%, about 0.3 to about 1.5 wt.%, about 0.3 to about 1 wt.%, about 0.2 to about 0.5 wt.%; from about 0.5 to about 4 wt.%, about 0.5 to about 3 wt.%, about 0.5 to about 2 wt.%, about 0.5 to about 1.5 wt.%; from about 0.75 to about 4 wt.%, about 0.75 to about 3 wt.%. about 0.75 to about 2 wt.%, about 0.75 to about 1.5 wt.%; from about 1 to about 5 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%, about 1 to about 2 wt.%; from about 1.5 to about 5 wt.%, about 1.5 to about 4 wt.%, about 1.5 to about 3 wt.%, about 1.5 to about 2 wt.%; from about 2 to about 5 wt.%, about 2 to about 4 wt.%, about 2 to about 3 wt.%; from about 2.5 to about 5 wt.%, about 2.5 to about 4 wt.%, about 2.5 to about 3.5 wt.%, or any range or subrange thereof, based on the total weight of the oral care composition.

[0099] The oral care composition typically comprises water. The total amount of water in the oral care composition may be from about 10 to about 36 wt.%, based on the total weight of the oral care composition. In some preferred embodiments, the total amount of water present in the oral care composition is from about 10 to about 36 wt.%, about 10 to about 31 wt.%, about 10 to about 26 wt.%, about 10 to about 23 wt.%, about 10 to about 21 wt.%, about 10 to about 19 wt.%, about 10 to about 17 wt.%, about 10 to about 15 wt.%; from about 13 to about 36 wt.%, about 13 to about 31 wt.%, about 13 to about 26 wt.%, about 13 to about 23 wt.%, about 13 to about 21 wt.%, about 13 to about 19 wt.%; from about 16 to about 36 wt.%, about 16 to about 31 wt.%, about 16 to about 26 wt.%, about 16 to about 23 wt.%, about 16 to about 21 wt.%; from about 19 to about 36 wt.%, about 19 to about 31 wt.%, about 19 to about 26 wt.%, about 19 to about 23 wt.%, about 19 to about 21 wt.%; from about 21 to about 36 wt.%, about 21 to about 31 wt.%, about 21 toDocket No. 1094755-00- WO-Ol-OC about 26 wt.%, about 21 to about 23 wt.%; from about 25 to about 36 wt.%, about 25 to about 31 wt.%, or any range or subrange thereof, based on the total weight of the oral care composition.

[0100] The oral care compositions may include one or more abrasive, e.g., in an amount of about 7 to about 30 wt.%, based on the total weight of the oral care composition. In some instances, the amount of abrasive(s) t in the oral care composition is from about 7 to about 27 wt.%, about 7 to about 23 wt.%, about 7 to about 19 wt.%, about 7 to about 17 wt.%, about 7 to about 15 wt.%, about 7 to about 13 wt.%; from about 10 to about 30 wt.%, about 10 to about 27 wt.%, about 10 to about 23 wt.%, about 10 to about 19 wt.%, about 10 to about 17 wt.%, about 10 to about 15 wt.%; from about 13 to about 30 wt.%, about 13 to about 27 wt.%, about 13 to about 23 wt.%, about 13 to about 19 wt.%, about 13 to about 17 wt.%, about 13 to about 15 wt.%; from about 15 to about 30 wt.%, about 15 to about 27 wt.%, about 15 to about 23 wt.%, about 15 to about 19 wt.%; from about 17 to about 30 wt.%, about 17 to about 27 wt.%, about 17 to about 23 wt.%; from about 19 to about 30 wt.%, about 19 to about 27 wt.%, about 19 to about 23 wt.%; from about 23 to about 30 wt.%, about 23 to about 27 wt.%. or any range or subrange thereof, based on the total weight of the oral care composition.

[0101] The abrasive(s) may comprise or be selected from silica abrasive, silicate, silicon, alumina (including calcined aluminum oxide), aluminosilicates, bentonite, zeolite, kaolin, mica, siliceous or diatomaceous earth, pumice, calcium compounds, calcium carbonate, cuttlebone, composite resins (such as melamine resin, phenolic resin, and urea-formaldehyde resin), polycarbonate, silicon carbide, boron carbide, microcrystalline wax, microcrystalline cellulose (e.g., combinations of colloidal microcrystalline cellulose and carboxymethylcellulose) dicalcium phosphate, calcium pyrophosphate, dicalcium orthophosphate dihydrate, tricalcium phosphate, calcium polymetaphosphate, calcium carbonate, calcium bicarbonate, and a combination of two or more thereof. In some embodiments, the oral care composition includes one or more of abrasives chosen from dicalcium phosphate, calcium pyrophosphate, dicalcium orthophosphate dihydrate, tricalcium phosphate, calcium polymetaphosphate, calcium carbonate, calcium bicarbonate, or a combination of two or more thereof. In further embodiments, the oral care composition comprises an abrasive selected from calcium carbonate, dicalcium orthophosphate dihydrate, calcium pyrophosphate, tricalcium phosphate, calcium polymetaphosphate, insoluble sodium polymetaphosphate, hydrated alumina, resinous abrasive materials such as particulate condensation products of urea and formaldehyde, and combinationsDocket No. 1094755-00- WO-Ol-OC thereof. Tn at least on preferred embodiment, the abrasive comprises or, preferably, consists of silica abrasive. For example, the abrasive(s) be selected from high cleaning silica.

[0102] The oral care composition may include KOH caustic potash in an amount from about 0.25 to about 5 wt.%, based on the total weight of the oral care composition. For example, the amount of KOH caustic potash in the oral care composition may, preferably, be from about 0.25 to about 4 wt.%. about 0.25 to about 3 wt.%, about 0.25 to about 2 wt.%. about 0.25 to about 1.5 wt.%, about 0.25 to about 1 wt.%; from about 0.5 to about 4 wt.%, about 0.5 to about 3 wt.%, about 0.5 to about 2 wt.%, about 0.5 to about 1.5 wt.%; from about 0.75 to about 4 wt.%, about 0.75 to about 3 wt.%, about 0.75 to about 2 wt.%, about 0.75 to about 1.5 wt.%; from about 1 to about 5 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%, about 1 to about 2 wt.%; from about 1.25 to about 5 wt.%, about 1.25 to about 4 wt.%, about 1.25 to about 3 wt.%, about 1.25 to about 2 wt.%; from about 1.5 to about 5 wt.%, about 1.5 to about 4 wt.%, about 1.5 to about 3 wt.%, about 1.5 to about 2 wt.%; from about 2 to about 5 wt.%, about 2 to about 4 wt.%, about 2 to about 3 wt.%; from about 2.5 to about 5 wt.%, about 2.5 to about 4 wt.%, about 2.5 to about 3.5 wt.%, or any range or subrange thereof, based on the total weight of the oral care composition.

[0103] The oral care compositions may include an anti-calculus agent. The amount of anti-calculus agent(s) present in the oral care composition may be from about 0.5 to about 10 wt.%, based on the total weight of the oral care composition. In some instances, the anti-calculus agent(s) is present in the oral care composition in an amount from about 0.5 to about 8 wt.%, about 0.5 to about 6 wt.%, about 0.5 to about 5 wt.%, about 0.5 to about 4 wt.%, about 0.5 to about 3 wt.%, about 0.5 to about 2 wt.%; from about 1 to about 10 wt.%, about 1 to about 8 wt.%, about 1 to about 6 wt.%, about 1 to about 5 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%, about 1 to about 2 wt.%; from about 2 to about 10 wt.%, about 2 to about 8 wt.%, about 2 to about 6 wt.%, about 2 to about 5 wt.%, about 2 to about 4 wt.%, about 2 to about 3 wt.%; from about 3 to about 10 wt.%, about 3 to about 8 wt.%, about 3 to about 6 wt.%, about 3 to about 5 wt.%, about 3 to about 4 wt.%; from about 5 to about 10 wt.%, about 5 to about 8 wt.%, about 5 to about 6 wt.%; from about 7 to about 10 wt.%, about 7 to about 8 wt.%, about 8 to about 10 wt.%, or any range or subrange thereof, based on the total weight of the oral care composition.

[0104] The anti-calculus agent(s) may be chosen from phosphates and polyphosphates (e.g., pyrophosphates), polyaminopropanesulfonic acid (AMPS), hexametaphosphate salts, zinc citrateDocket No. 1094755-00- WO-Ol-OC trihydrate, polypeptides, polyolefin sulfonates, polyolefin phosphates, diphosphonates, and combinations of two or more thereof. Examples of anti-calculus agents include tetrasodium pyrophosphate, ammonium tripolyphosphate, hexametaphosphate salt, polycarboxylate polymers, polyvinyl methyl ether / maleic anhydride (PVME / MA) copolymers, or combinations of two or more thereof. In some embodiments, the oral care composition includes one or more alkali metal polyphosphate, e.g.. as tetrasodium pyrophosphate.

[0105] The oral care compositions may optionally include a fluoride ion source. The fluoride ion source may be present in an effective amount. In some cases, the fluoride ion source is present in the oral care composition in an amount of about 0.01 to about 5 wt.%, based on the total weight of the oral care composition. For example, the fluoride ion source is present in an amount of about 0.01 to about 5 wt.%, about 0.01 to about 4 wt.%, about 0.01 to about 3 wt.%, about 0.01 to about2 wt.%, about 0.01 to about 1 wt.%; from about 0.05 to about 5 wt.%, about 0.05 to about 4 wt.%, about 0.05 to about 3 wt.%, about 0.05 to about 2 wt.%, about 0.05 to about 1 wt.%; from about 0.1 to about 5 wt.%, about 0.1 to about 4 wt.%, about 0.1 to about 3 wt.%, about 0.1 to about 2 wt.%; from about 0.3 to about 5 wt.%, about 0.3 to about 4 wt.%, about 0.3 to about 3 wt.%, about 0.3 to about 2 wt.%; from about 0.6 to about 5 wt.%, about 0.6 to about 4 wt.%, about 0.6 to about3 wt.%, about 0.6 to about 2 wt.%; from about 0.9 to about 5 wt.%, about 0.9 to about 4 wt.%, about 0.9 to about 3 wt.%, about 0.9 to about 2 wt.%; from about 1.2 to about 5 wt.%, about 1.2 to about 4 wt.%, about 1.2 to about 3 wt.%, about 1.2 to about 2 wt.%; from about 1.5 to about 5 wt.%, about 1.5 to about 4 wt.%, about 1.5 to about 3 wt.%; from about 2 to about 5 wt.%, about 2 to about 4 wt.%, about 2 to about 3 wt.%; from about 3 to about 5 wt.%, about 4 to about 5 wt.%, or any range or subrange thereof, based on the total weight of the oral care composition.

[0106] The fluoride ion source may be selected from soluble fluoride ion salts. For example, the fluoride ion source may comprise sodium fluoride, potassium fluoride, calcium fluoride, zinc fluoride, zinc ammonium fluoride, lithium fluoride, ammonium fluoride, stannous fluoride, stannous fluorozirconate, sodium monofluorophosphate, potassium monofluorophosphate, laurylamine hydrofluoride, diethylaminoethyloctoylamide hydrofluoride, didecyldimethylammonium fluoride, cetylpyridinium fluoride, dilaurylmorpholinium fluoride, sarcosine stannous fluoride, glycine potassium fluoride, glycine hydrofluoride, amine fluorides or a combination of two or more thereof. In some embodiments, the fluoride ion source comprises sodium fluoride, sodium monofluorophosphate, or a combination thereof. AdditionalDocket No. 1094755-00- WO-Ol-OC examples of fluoride ion source are disclosed in U.S. Patent No. 3,535,421 , U.S. Patent No.4,885,155, and U.S. Patent No. 3,678,154, the disclosure of each of which is hereby incorporated by reference in their entirety.

[0107] In certain embodiments, the oral care composition of the disclosure may contain a source of fluoride ions or fluorine-providing agents in amounts sufficient to deliver, in total, from 25 ppm to 25.000 ppm (mass fraction) of fluoride ions, generally at least 500 ppm, e.g., from about 500 to about 2000 ppm, from about 800 to about 1800 ppm, from about 1000 to about 1600 ppm, from about 1200 to about 1550 ppm, or about 1450 ppm.

[0108] The oral care compositions of the present disclosure may include a flavoring agent. The flavoring agent is typically incorporated in the oral care composition at a concentration of about 0.01 to about 3 wt.%, by weight of the oral care composition. For example, the amount of flavoring agent(s) present in the oral care composition may be from about 0.01 to about 2 wt.%, about 0.01 to about 1 wt.%, about 0.01 to about 0.5 wt.%, about 0.01 to about 0.1 wt.%; from about 0.1 to about 3 wt.%, about 0.1 to about 2 wt.%, about 0.1 to about 1 wt.%, about 0.1 to about 0.5 wt.%; from about 0.5 to about 3 wt.%, about 0.5 to about 2 wt.%, about 0.5 to about 1 wt.%; from about 1 to about 3 wt.%, about 1 to about 2 wt.%; from about 2 to about 3 wt.%, including any range or subrange thereof, based on the total weight of the oral care composition.

[0109] Suitable flavoring agents include, but are not limited to, essential oils and various flavoring aldehydes, esters, alcohols, and similar materials. Examples of the essential oils include oils of spearmint, peppermint, wintergreen, sassafras, clove, sage, eucalyptus, marjoram, cinnamon, lemon, lime, grapefruit, and orange. Also useful are such chemicals as menthol, carvone, and anethole. Additional flavoring agents may include, but are not limited to menthol, artificial vanilla, cinnamon derivatives, and various fruit flavors, spearmint oil, peppermint oil, cinnamon oil, oil of wintergreen (methylsalicylate), clove oil, bay oil, anise oil, eucalyptus oil, thyme oil, cedar leaf oil, oil of nutmeg, oil of sage, oil of bitter almonds, cassia oil. and a combination of two or more thereof.

[0110] The oral care compositions may include one or more colorants. Exemplary colorants can include natural or uncertified colors from natural sources or certified colors for the effect of color. In some embodiments, the colorant can include dyes, certified aluminum lakes or colors derived from a natural source. The colorant may be water-based, oil-based or dry. The colorants can be primary colors, blends of colors or discrete mixtures of colors, such as confetti. The concentrationsDocket No. 1094755-00- WO-Ol-OC of the colorant in the oral care composition may be from trace amount to about 0.6 wt.%, about 0.1 to about 0.5 wt.%, about 0.2 to about 0.4 wt.%, or about 0.15 to about 0.35 wt.%, based on the total weight of the oral care composition.

[0111] The oral care composition may include one or more pH adjusters to increase or decrease the overall pH of the oral care composition. For example, one or more acids may be included to decrease the pH of the oral care composition. Examples of suitable acids for decreasing the pH of the oral care composition include, but are not limited to, citric acid, acetic acid, and the like. The oral care composition may include one or more bases, such as sodium hydroxide, potassium hydroxide and the like, to increase the pH of the oral care composition. Additional or alternative acids and bases that are suitable for adjusting the pH of the oral care composition are readily known to one of ordinary skill in the art.

[0112] The amount of the pH adjuster in the oral care composition may be based on the desired pH of the final oral care composition and / or product. For example, the total amount of the pH adjuster may range from about 0.05 to about 20 wt.%. based on the total weight of the oral care composition. In some instances, the total amount of pH adjuster is from about 0.05 to about 15 wt.%, about 0.1 to about 10 wt.%, or about 0.12 to about 5 wt.%, including ranges and sub-ranges therebetween, based on the total weight of the oral care composition.

[0113] The oral care compositions may have a pH from 4.5 to about 10, 4.5 to about 9, 4.5 to about 8, 4.5 to about 7, 4.5 to about 6; from about 5 to about 10, about 5 to about 9, about 5 to about 8, about 5 to about 7, about 5 to about 6; from about 6 to about 10, about 6 to about 9, about 6 to about 8, or about 6 to about 7; from about 7 to about 10, about 7 to about 9, or about 7 to about 8, including any ranges and subranges therebetween.

[0114] According to yet an additional aspect, provided is an oral care composition for the use in an oral care product having a pump to reduce clogging within such pump, the oral care composition comprising: from about 36 to about 72 wt.% of a polyol system; a thickening system comprising from about 0.4 to about 2.6 wt.% of a silica thickener, a natural gum, and a cellulose; one or more surfactant; and from about 10 to about 36 wt.% of water, wherein all weight percentages are based on the total weight of the oral care composition. Preferably, the oral care compositions for use in an oral care product having a pump to reduce clogging within such pump have an instability index of 0.04 or less, more preferably about 0.025 or less, more preferably about 0.02 or less, as measured according to a Lumisizer test. In further preferred embodiments, the oral care compositions for useDocket No. 1094755-00- WO-Ol-OC in an oral care product having a pump to reduce clogging within such pump have a pumping viscosity of 2.5 to 4.5, preferably 2.8 to 4.2, or preferably 3 to 4.2, during dispensing of the oral care composition with such pump. Additionally, or alternatively, the oral care compositions for use in an oral care product having a pump to reduce clogging within such pump have a pumping force of 30 to 45 or about 35 to about 43 to dispense the oral care composition with such pump. In some preferred embodiments, the oral care compositions for use in an oral care product having a pump to reduce clogging within such pump has a yield stress of 30 to 40, preferably about 35 to about 38, during dispensing of the oral care composition with such pump.EXAMPLESExample 1

[0115] Four non-limiting example oral care compositions were prepared in the form of dentifrices in accordance with aspects of the invention. Four comparative compositions (Comparative Compositions 1-4) were also prepared in the form of dentifrices. The formulas used for Example Compositions A-D and Comparative Compositions 1-4 are provided in Table 1.Docket No. 1094755-00- WO-OLOCTable 1Example 2

[0116] Example Compositions A-D and Comparative Compositions 1-4 were disposed in an oral care container comprising a body defining a chamber and a pump. The oral care containers and respective dentifrices therein were placed in a controlled environment having a temperature of 49° C for 1 day to age the respective dentifrices. The oral care containers were evaluated for clogging withing the pump.

[0117] Example Compositions A-D and Comparative Compositions 1-4 were then evaluated to assess their stability. Specifically, a Lumisizer test is conducted to predict the stability of formulations. The Lumisizer analytical centrifuge test (referred to herein also as a “Lumisizer test”) is a test method that aims to predict gravity-driven separation of toothpaste formula within its intended shelf life. In general, the instability index of 0.05 or less suggests a shelf life of at least 2 years. A lower instability index indicates better product stability performance and a significantDocket No. 1094755-00- WO-Ol-OC reduction of clogging within the pump. The instability index for Example Compositions A-D and Comparative Compositions 1-4 is shown in FIG. 3Example 3

[0118] The rheology properties, including the pumping viscosity, pumping force, and yield stress for Example Compositions B and D and Comparative Compositions 1 and 2 were evaluated. The pumping viscosity indicates the gel dispensing performance. The yield stress indicates the amount of stress to make the oral care composition flow through the pump. A summary of the pumping viscosity, pumping force, and yield stress for Example Compositions B and D and Comparative Compositions 1 and 2 is provided in Table 2.Table 2

Claims

Docket No. 1094755-00- WO-Ol-OCCLAIMSWhat is Claimed is:

1. An oral care product comprising: a container comprising a body defining a chamber and a pump, the pump extending into the chamber of the body; an oral care composition disposed in the chamber, the oral care composition comprising: from about 36 to about 72 wt.% of a polyol system; a thickening system comprising: from about 0.4 to about 2.6 wt.% of a silica thickener, a natural gum, and a cellulose; one or more surfactant; and from about 10 to about 36 wt.% of water, wherein all weight percentages are based on the total weight of the oral care composition.

2. The oral care product according to claim 1, wherein the oral care composition has an instability index of 0.04 or less, as measured according to a Lumisizer test.

3. The oral care product according to claim 1 or claim 2, wherein the silica thickener is present in an amount from about 0.7 to about 2.2 wt.%.

4. The oral care product according to any foregoing claim, wherein the natural gum is selected from the group consisting of gum arabic, tragacanth gum. karaya gum, agarose, guar gum, pechtin, gellan gum, tara gum, locust bean gum, tamarind gum, locust bean gum, Seneca gum, sclerotium gum, gellan gum, xanthan gum, and a combination of two or more thereof.

5. The oral care product according to any foregoing claim, wherein the cellulose is selected from the group consisting of carboxymethylcellulose, ethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, methylhydroxyethylcellulose, and a combination of two or more thereof.Docket No. 1094755-00- WO-Ol-OC6. The oral care product according to any foregoing claim, wherein the oral care composition comprises xanthan gum and carboxymethyl cellulose in a weight ratio of the xanthan gum to the carboxymethyl cellulose of about 10:1 to about 2:1.

7. The oral care product according to any foregoing claim, wherein the one or more surfactant is selected from an anionic surfactant, an amphoteric surfactant, and a combination of two or more thereof.

8. The oral care product according to claim 7, wherein the anionic surfactant comprises sodium lauryl sulfate, sodium lauryl ether sulfate, ammonium lauryl sulfate, ammonium lauryl ether sulfate, sodium dodecyl sulfate, sodium coco-sulfate, ammonium coco-sulfate, or a combination thereof.

9. The oral care product according to claim 7 or claim 8, wherein the amphoteric surfactant comprises a betaine surfactant.

10. The oral care product according to any foregoing claim, wherein the one or more surfactant is selected from the group consisting of cocamidopropyl betaine, sodium lauryl sulfate, sodium lauryl ether sulfate, and a combination of two or more thereof.

11. The oral care product according to any foregoing claim, wherein glycerin comprises about 82 wt.% or more of the polyol system, based on the total weight of the polyols in the oral care composition.

12. The oral care product according to any foregoing claim, wherein the oral care composition is substantially free of or free of sorbitol.

13. The oral care product according to any foregoing claim, wherein the polyol system consists of glycerin, a polyethylene glycol, and a combination thereof.Docket No. 1094755-00- WO-Ol-OC14. The oral care product according to any foregoing claim, wherein the thickening system is present in a total amount of about 1 to about 5 wt.%.

15. The oral care product according to any foregoing claim, wherein the pump comprises a dip tube having a cross-sectional diameter of about 5 to about 15 mm.

16. The oral care product according to any foregoing claim, wherein the pump comprises a nozzle having a nozzle length of about 7 to about 25 mm.

17. The oral care product according to any foregoing claim, wherein the pump comprises a nozzle having a passageway with a smallest cross-sectional area of about 4 to about 10 mm2.

18. An oral care product comprising: a container comprising a body defining a chamber and a pump, the pump extending into the chamber of the body; an oral care composition disposed in the chamber, the oral care composition comprising: from about 41 to about 67 wt.% of a polyol; a thickening system consisting of: from about 0.4 to about 2.6 wt.% of a silica thickener, xanthan gum, and carboxymethyl cellulose, wherein the xanthan gum and the carboxymethyl cellulose are present in a weight ratio of about 10: 1 to about 2: 1; one or more surfactant comprising a betaine surfactant; and from about 13 to about 23 wt.% of water, wherein all weight percentages are based on the total weight of the oral care composition.

19. An oral care composition adapted for being dispensed using a pump, the oral care composition comprising: from about 36 to about 72 wt.% of a polyol system; a thickening system comprising: from about 0.4 to about 2.6 wt.% of a silica thickener,Docket No. 1094755-00- WO-Ol-OC a natural gum, and a cellulose; one or more surfactant; and from about 10 to about 36 wt.% of water, wherein all weight percentages are based on the total weight of the oral care composition.

20. An oral care composition for use in an oral care product having a pump to reduce clogging within such pump, the oral care composition comprising: from about 36 to about 72 wt.% of a polyol system; a thickening system comprising: from about 0.4 to about 2.6 wt.% of a silica thickener, a natural gum, and a cellulose; one or more surfactant; and from about 10 to about 36 wt.% of water, wherein all weight percentages are based on the total weight of the oral care composition.

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