PORE constructs and their uses
Novel oligomeric pore constructs integrate translocase and transmembrane protein regions to efficiently control and characterize analytes, addressing inefficiencies in existing nanopore sensing technologies by reducing the need for multiple enzymes and enhancing stability.
Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- OXFORD NANOPORE TECH LTD
- Filing Date
- 2025-12-05
- Publication Date
- 2026-06-11
AI Technical Summary
Existing nanopore sensing technologies require multiple enzymes and pores for analyte characterization, leading to inefficiencies and potential disengagement of translocases from target analytes, which complicates the control and discrimination of analyte movement through the pore.
Development of novel oligomeric pore constructs combining regions from oligomeric translocases and transmembrane protein pores, allowing for a single subunit to control and characterize target analytes efficiently, reducing the need for excess translocases and minimizing disengagement.
The oligomeric pore constructs enable efficient analyte characterization by controlling movement and discriminating analytes, reducing ATP consumption and enhancing the stability of the analyte detection process.
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