An Anti-inflammatory lactobacillus acidophilus composition for regulating immune responses

The combination of live-bacteria and postbiotic powders of Lactobacillus acidophilus, Lactobacillus plantarum, and Bifidobacterium longum addresses the limitations of existing probiotics by enhancing strain synergy and stability, achieving comprehensive immune regulation and intestinal barrier repair.

WO2026126192A2 Publication Date: 2026-06-18JABAR YASSINE
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Patent Information

Application Number
PCT/IB2026/053900
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Filing Date
2026-04-20
Publication Date
2026-06-18

AI Technical Summary

Technical Problem

Existing probiotic preparations for anti-inflammatory and immune-regulating purposes suffer from insufficient strain synergy, poor environmental tolerance of live bacteria, instability due to acidic and alkaline environments, and potential safety risks from exogenous additives, failing to achieve comprehensive immune regulation and intestinal barrier repair.

Method used

A composition comprising live-bacteria and homologous postbiotic lyophilized powders of Lactobacillus acidophilus, Lactobacillus plantarum, and Bifidobacterium longum, with a specific mass ratio and preparation process ensuring stability and safety, avoiding exogenous additives.

Benefits of technology

The composition achieves deep synergistic enhancement of strain efficacy, providing immediate and long-term immune regulation, inflammation suppression, and intestinal barrier repair, while ensuring safety and stability.

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Abstract

The present invention discloses an anti-inflammatory Lactobacillus acidophilus composition for regulating immune responses, belonging to the fields of microbial technology and biomedicine. The composition comprises live lyophilized powders of Lactobacillus acidophilus, Lactobacillus plantarum, and Bifidobacterium longum, together with homologous postbiotic lyophilized powders of the same strains. By combining functionally complementary probiotics with their homologous postbiotics, a full-chain anti-inflammatory system is constructed, covering immune regulation, inflammation suppression, and intestinal barrier repair. The live bacteria enable long-term colonization and microecological regulation, while the postbiotics act rapidly, producing a synergistic effect. The composition is prepared solely from strain-derived fermentation products without exogenous additives, ensuring safety and purity, and provides a stable and efficient solution for inflammation relief and immune function optimization.
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