Oral composition

Abstract

The present invention addresses the problem of providing a low-foaming oral composition in which the separation and expression of oily components such as oils derived from a fragrance are suppressed. Specifically, the present invention provides an oral composition containing an anionic surfactant serving as an (A) component, water serving as a (B) component, xanthan gum and / or carboxymethyl cellulose serving as (C) component, an inorganic powder serving as a (D) component, and a fragrance serving as an (E) component, wherein the content of each of the components (A), (B), and (C) is 0.1-1.0 mass%, 1-35 mass%, and 0.01-2.0 mass%, respectively.

Description

Oral composition

[0001] The present invention relates to an oral composition.

[0002] Low-foaming oral compositions, such as dentifrices, have the characteristic that the foam after toothbrushing can be removed from the oral cavity by a light rinsing or simple wiping operation, and there is little concern about aftertaste or residual irritation. For example, Patent Document 1 describes an oral composition containing a nonionic bactericide, triacyl glycerol, vegetable oil and animal oil, a nonionic surfactant, and a fragrance component in a predetermined amount and substantially free of an anionic surfactant, which is low-foaming and low-fragrance and has a good feeling in use.

[0003] Japanese Patent Application Laid-Open No. 2023-083626

[0004] However, in an oral composition such as that of Patent Document 1, oily components such as oil derived from the fragrance may separate and appear during storage.

[0005] An object of the present invention is to provide a low-foaming oral composition in which separation and appearance of oily components such as oil derived from the fragrance are suppressed.

[0006] The present invention provides [1] to [5]. [1] Component (A): an anionic surfactant, Component (B): water, Component (C): xanthan gum and / or carboxymethyl cellulose, Component (D): inorganic powder, Component (E): a fragrance, and the contents of components (A), (B), and (C) are 0.1 to 1.0% by mass, 1 to 35% by mass, and 0.01 to 2.0% by mass, respectively, An oral composition. [2] The oral composition according to [1], wherein the mass ratio ((A) / ((B)+(C))) of the content of component (A) to the total content of components (B) and (C) is 0.001 to 0.6. [3] The oral composition according to [1] or [2], wherein the mass ratio ((D) / ((B)+(C))) of the content of component (D) to the total content of components (B) and (C) is 0.0015 to 11. [4] The oral composition according to any one of [1] to [3], wherein the content of component (D) is 1 to 20% by mass. [5] The oral composition according to any one of [1] to [4], wherein the content of a fragrance having a logP of less than 3 with respect to the whole oral composition is 0.8% by mass or less.

[0007] According to the present invention, an oral composition is provided that contains an anionic surfactant, water, and xanthan gum, thereby suppressing the separation and expression of oily components such as oils derived from fragrances; further containing inorganic powder, thereby suppressing the development of stringiness caused by water and xanthan gum; and achieving an appropriate amount of foam due to the anionic surfactant.

[0008] [1. Components and composition of the oral composition] The oral composition of the present invention contains components (A) to (E).

[0009] [1.1 Component (A): Anionic surfactant] Component (A) is an anionic surfactant. Component (A), along with components (B) and (C), can suppress the separation and expression of oily components derived from other components such as component (E).

[0010] Examples of anionic surfactants include alkyl sulfates, acyl amino acid salts, acyl taurine salts, α-olefin sulfonates, hydrogenated coconut fatty acid monoglyceride monosulfates, and lauryl sulfoacetate. The alkyl and acyl groups that the anionic surfactant may have may be linear or branched, and may be saturated or unsaturated. The number of carbon atoms in the alkyl and acyl groups is preferably 8 to 20, more preferably 10 to 20, and even more preferably 10 to 18. When the anionic surfactant is a salt, it may be selected from pharmaceutically acceptable salts such as base addition salts and amino acid salts, for example, inorganic base salts such as sodium salts, potassium salts, calcium salts, magnesium salts, and ammonium salts; organic base salts such as triethylammonium salts, triethanolammonium salts, pyridinium salts, and diisopropylammonium salts; and basic amino acid salts such as arginine salts. Among these, inorganic base salts are preferred, alkali metal salts (e.g., sodium salts, potassium salts) or ammonium salts are more preferred, and sodium salts are even more preferred.

[0011] Examples of alkyl sulfates include lauryl sulfate (dodecyl sulfate) and myristoyl sulfate. As for α-olefin sulfonates, tetradecene sulfonate is preferred. Examples of acyl amino acid salts include acyl sarcosine salts such as lauroyl sarcosine salt and myristoyl sarcosine salt; acyl glutamates such as lauroyl glutamate, myristoyl glutamate, and palmitoyl glutamate; acyl glycine salts such as N-lauroyl-N-methylglycine salt and cocoyl glycine salt; acyl alanine salts such as N-lauroyl-β-alanine salt, N-myristyl-β-alanine salt, N-cocoyl-β-alanine salt, N-lauroyl-N-methyl-β-alanine salt, N-myristoyl-N-methyl-β-alanine salt, and N-cocoyl-N-methyl-β-alanine salt; and acyl aspartates such as lauroyl aspartate salt. Examples of acyl taurine salts include lauroyl methyl taurine salt and N-cocoyl methyl taurine salt. Other examples of anionic surfactants include hydrogenated coconut fatty acid monoglyceride monosulfate sodium, lauryl sulfoacetate sodium, and sulfosuccinates (e.g., polyoxyethylene (2) alkyl (12-14) sulfosuccinate). Of these, alkyl sulfates, α-olefin sulfonates, and acyl amino acid salts are preferred, dodecyl sulfates, tetradecene sulfonates, and acyl sarcosinates are more preferred, and sodium lauryl sulfate, sodium tetradecene sulfonate, and sodium lauroyl sarcosinate are even more preferred.

[0012] Component (A) may be a single type or a combination of two or more types. In the case of a combination of two or more types, it is preferable to include at least dodecyl sulfate (SDS). The mass ratio of the dodecyl sulfate content to the content of component (A) is preferably 0.3 or more, more preferably 0.35 or more, and even more preferably 0.4 or more. There is no particular upper limit, but for example, it may be 1 or less, 0.8 or less, 0.7 or less, or 0.6 or less. As the other one or more anionic surfactants, tetradecenesulfonate (TDS) and / or lauroyl sarcosinate are preferred. When component (A) contains tetradecenesulfonate and lauroyl sarcosinate, the ratio of the tetradecenesulfonate content to the lauroyl sarcosinate content is preferably 1.5 to 4, more preferably 2 to 3.5, and even more preferably 2.5 to 3.

[0013] The content of component (A) is 0.1% by mass or more, preferably 0.2% by mass or more, and more preferably 0.3% by mass or more. This can suppress the separation and expression of oil components in the oral composition, resulting in good stability. It can also exhibit good foaming properties. The effects of component (A) can be exerted. The upper limit is 1.0% by mass or less, preferably 0.8% by mass or less, and more preferably 0.7% by mass or less. This allows it to be used as a low-foaming oral composition. Therefore, it is 0.1 to 1.0% by mass, preferably 0.2 to 0.8% by mass, and more preferably 0.3 to 0.7% by mass.

[0014] In this specification, unless otherwise specified, the content of each component is based on the amount of each component used when manufacturing the oral composition. Furthermore, unless otherwise specified, it means mass percent relative to 100% by mass of the total amount of the oral composition.

[0015] [1.2 Component (B): Water] Component (B) is water. Component (B), together with components (A) and (C), helps to suppress the separation and expression of oily components derived from fragrances, etc.

[0016] Water can be, for example, purified water, deionized water, alkaline ionized water, hard water, or soft water, and is not particularly limited to any specific type.

[0017] The content of component (B) is 1% by mass or more, preferably 5% by mass or more, more preferably 10% by mass or more, even more preferably 15% by mass or more, and even more preferably 18% by mass or more. This can suppress the separation and expression of oil components in the oral composition, and can result in good stability. The upper limit is 35% by mass or less, preferably 34% by mass or less, more preferably 33% by mass or less, even more preferably 32% by mass or less, and even more preferably 30% by mass or less. This can suppress an excessive increase in stringiness and maintain good foaming properties. Therefore, it is 1 to 35% by mass, preferably 5 to 34% by mass, more preferably 10 to 33% by mass, even more preferably 15 to 32% by mass, and even more preferably 18 to 30% by mass.

[0018] If the composition contains potassium nitrate, the ratio of the content of component (B) to the content of potassium nitrate is preferably 0.19 or more, more preferably 2 or more, even more preferably 2 to 6, and even more preferably 2 to 5.

[0019] [1.3 Component (C): Xanthan gum, carboxymethylcellulose] Component (C) is xanthan gum and / or carboxymethylcellulose. Xanthan gum and carboxymethylcellulose are water-soluble polysaccharides and, together with components (A) and (B), can suppress the separation and expression of oily components derived from fragrances, etc. They can also function as thickeners (binders). Carboxymethylcellulose may also be in the form of a salt (e.g., sodium salt, calcium salt). The amount of carboxymethyl groups (degree of carboxymethyl substitution) is not particularly limited, but is preferably 0.5 to 1.5, more preferably 0.6 to 1.4, even more preferably 0.7 to 1.3, and even more preferably 0.8 to 1.2.

[0020] Component (C) may be either xanthan gum or carboxymethylcellulose, or both. In the case of both xanthan gum and carboxymethylcellulose, the mass ratio of the xanthan gum content to the carboxymethylcellulose content can be determined as appropriate.

[0021] The content of component (C) is 0.01% by mass or more, preferably 0.05% by mass or more, more preferably 0.07% by mass or more, even more preferably 0.08% by mass or more, even more preferably 0.1% by mass or more, particularly preferably 0.15% by mass or more, or 0.2% by mass or more. This suppresses the separation and expression of oil components in the oral composition. The upper limit is 2.0% by mass or less, preferably 1.0% by mass or less, more preferably 0.9% by mass or less, even more preferably 0.7% by mass or less, even more preferably 0.5% by mass or less, and particularly preferably 0.4% by mass or less. This suppresses an excessive increase in stringiness and maintains good foaming properties. Therefore, the amount is 0.01 to 2% by mass, preferably 0.05 to 1% by mass, more preferably 0.07 to 0.9% by mass, 0.08 to 0.9% by mass, even more preferably 0.1 to 0.7% by mass, even more preferably 0.15 to 0.5% by mass, and particularly preferably 0.2 to 0.4% by mass.

[0022] [1.4 Component (D): Inorganic Powder] Component (D) is an inorganic powder. Component (D) can suppress the development of stringiness. It can also exhibit functions such as an abrasive and a binder (thickener).

[0023] Examples of inorganic powders include silica-based powders (anhydrous silicic acid (e.g., thickening anhydrous silicic acid (thickening silica), abrasive anhydrous silicic acid (abrasive silica)), zeolite, settling silica, aluminosilicate, zirconosilicate, titanium-bonded silica, silica gel, etc.); titanium-based powders such as titanium oxide; zinc-based powders such as zinc oxide; phosphorus-based powders such as anhydrous sodium hydrogen phosphate; inorganic calcium salts (e.g., discalcium phosphate dihydrate or anhydrous, monocalcium phosphate, calcium pyrophosphate, insoluble calcium metaphosphate, tricalcium phosphate, tetracalcium phosphate, octacalcium phosphate, etc., calcium phosphate, calcium carbonate (light, heavy), calcium hydroxide, calcium sulfate, calcium oxide); aluminum-based powders such as aluminum hydroxide and alumina; magnesium-based powders such as magnesium carbonate and trimagnesium phosphate; apatite-based powders such as hydroxyapatite, fluoroapatite, and calcium-deficient apatite; and bentonite. Of these, silica-based powders, titanium-based powders, zinc-based powders, and aluminum-based powders are preferred, thickening anhydrous silicic acid (thickening silica), thickening anhydrous silicic acid (abrasive silica), titanium dioxide, zinc oxide, aluminum oxide, heavy calcium carbonate, and anhydrous calcium hydrogen phosphate are more preferred, and thickening anhydrous silicic acid, abrasive anhydrous silicic acid, and titanium dioxide are even more preferred.

[0024] Examples of abrasive anhydrous silica include precipitated silica, crystalline silica, igneous silica, amorphous silica, silica gel, aluminosilicate, zirconosilicate, and titanium-bonded silica. Abrasive anhydrous silica has a liquid absorption capacity of less than 2.0 mL / g, an average particle size of 1 to 40 μm, or a BET specific surface area of ​​20 to 250 m² per g. ２ It is preferable that the amount is / g or that two or more of these conditions are met. In this specification, the average particle size is the volume-based median diameter (D50) measured by laser diffraction / scattering. The abrasive anhydrous silicic acid may be a single type or a combination of two or more types.

[0025] Examples of thickening anhydrous silicic acid include silica obtained by known manufacturing methods, such as precipitated silica with a liquid absorption capacity of 3.5 mL / g or more, precipitated silica with a liquid absorption capacity of 2.0 mL / g to 3.0 mL / g, and igneous silica. Thickening anhydrous silicic acid has a BET specific surface area of ​​170 to 230 m². ２ It is preferable that the concentration is either / g, or the bulk density is 130 to 160 g / L, or both. The thickening anhydrous silicic acid may be one type of thickening anhydrous silicic acid alone, or a combination of two or more types.

[0026] Component (D) may be a single type or a combination of two or more types, but it is preferable to include at least a thickening anhydrous silicic acid and / or an abrasive anhydrous silicic acid. The mass ratio of the content of thickening anhydrous silicic acid to the content of component (D) is preferably 0.1 or more, more preferably 0.15 or more, and even more preferably 0.2 or more. The mass ratio of the content of abrasive anhydrous silicic acid to the content of component (D) is preferably 0.3 or more, more preferably 0.4 or more, and even more preferably 0.5 or more. There is no particular upper limit, but for example, it is 1 or less, 0.9 or less, or 0.8 or less. Therefore, the mass ratio is preferably 0.3 to 1, more preferably 0.4 to 0.9, and even more preferably 0.5 to 0.8. If component (D) contains titanium dioxide, the mass ratio of the content of titanium dioxide to the content of component (D) is preferably 0.005 or more, more preferably 0.01 or more, and even more preferably 0.02 or more. The upper limit is not particularly limited, but for example, it may be 1 or less, 0.3 or less, or 0.1 or less. Therefore, the mass ratio is preferably 0.005 to 1, more preferably 0.01 to 0.3, and even more preferably 0.02 to 0.1.

[0027] The content of component (D) is preferably 0.3% by mass or more, more preferably 0.5% by mass or more, even more preferably 0.7% by mass or more, even more preferably 0.9% by mass or more, and particularly preferably 1% by mass or more, 2% by mass or more, and 3% by mass or more. This suppresses stringiness, and the upper limit is preferably 30% by mass or less, more preferably 25% by mass or less, even more preferably 23% by mass or less, even more preferably 22% by mass or less, particularly preferably 20% by mass or less, 18% by mass or less, and 15% by mass or less. Therefore, it is preferably 0.3 to 30% by mass, more preferably 0.5 to 25% by mass, even more preferably 0.7 to 23% by mass, even more preferably 0.9 to 22% by mass, and particularly preferably 1 to 20% by mass, 2 to 18% by mass, and 3 to 15% by mass.

[0028] [1.5 (E) Component: Fragrance] Component (E) is a fragrance. Component (C) can be used to add flavor to oral compositions. Examples of fragrances include natural oils such as peppermint oil, spearmint oil, Japanese mint oil, anise oil, cassia oil, eucalyptus oil, wintergreen oil, mastic oil, neroli oil (orange blossom oil), lemongrass oil, jasmine oil, iris oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, laurel oil, chamomile oil, coriander oil, caraway oil, basil oil, marjoram oil, lemon oil, orange oil, lime oil, mandarin oil, grapefruit oil, yuzu oil, nutmeg oil, lavender oil, paracles oil, vanilla oil, cinnamon oil, pimento oil, cinnamon leaf oil, perilla oil, wintergreen oil, and rose oil. Essential oils; fragrance components contained in the above natural essential oils, such as carvone, 1,8-cineole, anethole, cinnamic aldehyde, eugenol, methyl salicylate, thymol, limonene, p-methoxycinnamic aldehyde, linalool, linalool oxide, menthone, menthyl acetate, citral, decanal, camphor, borneol, pinene, spiranthol, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, ethyl linalool, methyl jasmonate, vanillin, vanilla, germacrene, caryophyllene, viridiflorol, etc.Ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, cis-3-hexenol, trans-2-hexenal, hexyl acetate, ethyl-2-methyl butyrate, benzyl alcohol, linalyl acetate, phenylethyl glycidate, phenylethyl alcohol, allyl hexanoate, octanol, methyl cinnamate, methylheptin carbonate, ionone, ethyl-β-methylthiopropionate, cis-6-nonenol, methyl anthranilate, ethyl methylphenyl glycidate, benzaldehyde, ethyl vanillin, vanillyl butyl ether, furaneol, undecalactone, decalactone, Fragrance components such as ethylcyclopentenolone, 3-hydroxy-4,5-dimethylfuran-2-one, cyclotene, 2-methylbutyric acid, acetate acid, propionic acid, menthofran, maltol, ethylmaltol, N-ethyl-p-menthane-3-carboxamide (N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide), 7-methyl-3,5-dihydro-2H-benzodioxepin-3-one, menthyl lactate, ethylene glycol-l-menthyl carbonate, caron, etc.; plant extracts such as chili pepper extract, ginger extract, pepper extract, Japanese pepper extract, cardamom extract, vanilla extract, etc.This also includes various blended flavors such as mint, fruit, and herb, which are created by combining several fragrance components and natural essential oils. Furthermore, fragrances that can also function as cooling agents include, for example, menthol, N-ethyl-p-menthane-3-carboxamide (N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide), menthyl monosuccinate, menthyl glutarate, isopulegol, menthol glycoside ketal, N-(4-cyanomethylphenyl)-p-menthanecarboxamide, 3-l-mentoxypropane-1,2-diol, 3-((-)-mentoxy)propane-1,2-diol, 5-methyl-2-propane-2-yl-N-(2-pyridine-2-ylethyl)cyclohexane-1-carboxamide, 3-(p-menthane-3carboxamide)ethyl acetate, 2-isopropyl-N,2,3-trimethylbutylamide, N-[(ethoxycarbonyl)methyl]-p-menthane-3- Other examples include carboxamide, N-p-benzene asotonitrile menthanecarboxamide, N-(2-(pyridine-2-yl)ethyl)-3-p-menthanecarboxamide, N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide, 2-(4-methylphenoxy)-N-(1H-pyrazole-3-yl)-N-(thiophen-2-ylmethyl)acetamide, menthyl glyceryl ether, menthyl succinate, N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide, N-ethyl-2,2-diisopropylbutanamide, N-(1,1-dimethyl-2-hydroxyethyl)-2,2-diethylbutanamide, and N-(2-hydroxyethyl)-2,3-dimethyl-2-isopropylbutanamide. The fragrance may contain a solvent, such as ethanol, propylene glycol, glycerin fatty acid ester, or triacetin. Component (D) may be a single fragrance or a combination of two or more.

[0029] Component (E) preferably contains a hydrophobic fragrance, and more preferably contains a fragrance with a logP of greater than 3. Highly hydrophobic fragrances may cause separation and expression of oil components in the oral composition, but this can be suppressed by combining them with components (A) to (D) (especially components (A) to (C)). In this specification, logP is the partition coefficient of the fragrance component between n-octanol and water, expressed as a common logarithm, with a larger value indicating higher hydrophobicity.

[0030] Hydrophobic fragrance components include, for example, menthol, carvone, 1,8-cineole, anethole, cinnamic aldehyde, eugenol, methyl salicylate, thymol, and limonene. Component (E) preferably contains at least one selected from these.

[0031] If component (E) contains a fragrance component with a logP of less than 3, the content of the fragrance with a logP of 3 or less in relation to the entire oral composition is preferably 0.8% by mass or less, more preferably 0.4% by mass or less, and even more preferably 0.1% by mass or less. Examples of fragrance components with a logP of less than 3 include furaneol, cis-3-hexenol, benzyl alcohol, vanillin, phenylethyl alcohol, ethyl vanillin, trans-2-hexenol, cinnamic aldehyde, eugenol, ethyl-2-methyl butyrate, p-methoxycinnamic aldehyde, methyl jasmonate, α-terpineol, menthone, maltol, camphor, isopulegol, ethyl butyrate, methyl salicylate, isoamyl acetate, carvone, linalool, neral, and ethyl maltol.

[0032] The content of component (E) can be appropriately determined depending on the type of fragrance, but for example, it can be 0.00001% by mass or more, 0.0001% by mass or more, 0.001% by mass or more, 0.01% by mass or more, and 0.1% by mass or more, with upper limits of 2.0% by mass or less, 1.9% by mass or less, 1.8% by mass or less, 1.7% by mass or less, 1.6% by mass or less, and 1.5% by mass or less. Therefore, the content of component (E) can be, for example, 0.00001 to 2.0% by mass, 0.0001 to 1.9% by mass, 0.0001 to 1.8% by mass, 0.001 to 1.7% by mass, 0.01 to 1.6% by mass, and 0.1 to 1.5% by mass.

[0033] [1.6 Mass ratio of each component] -(A) / ((B)+(C)) mass ratio- The mass ratio of the content of component (A) to the total content of components (B) and (C) ((A) / ((B)+(C))) is preferably 0.001 or more, more preferably 0.003 or more, even more preferably 0.005 or more, even more preferably 0.007 or more, and particularly preferably 0.01 or more, 0.02 or more. The upper limit is preferably 0.6 or less, more preferably 0.5 or less, even more preferably 0.3 or less, even more preferably 0.1 or less, and particularly preferably 0.09 or less, 0.06 or less, 0.04 or less. Therefore, preferably 0.001 to 0.6, more preferably 0.003 to 0.5, even more preferably 0.005 to 0.3, even more preferably 0.007 to 0.1, and particularly preferably 0.01 to 0.09, 0.01 to 0.06, and 0.02 to 0.04. By being within the above upper and lower limits or numerical ranges, a good balance can be achieved in suppressing the separation and expression of oil components of the oral composition, and in improving appropriate stringiness and foaming properties.

[0034] -(D) / ((B)+(C)) Mass Ratio- The mass ratio of the content of component (D) to the total content of components (B) and (C) ((D) / ((B)+(C))) is preferably 0.0015 or more, more preferably 0.002 or more, even more preferably 0.0025 or more, even more preferably 0.003 or more, particularly preferably 0.0035 or more, and 0.004 or more. The upper limit is preferably 11 or less, more preferably 10 or less, even more preferably 8 or less, even more preferably 6 or less, particularly preferably 3 or less, 1 or less, and 0.7 or less. Therefore, it is preferably 0.0015 to 11, more preferably 0.002 to 10, even more preferably 0.0025 to 8, even more preferably 0.003 to 6, particularly preferably 0.0035 to 3, 0.004 to 1, and 0.02 to 0.7. By being within the above upper and lower limits or numerical ranges, the separation and expression of oil components of the oral composition, as well as the appropriate stringiness and foaming properties, can be suppressed in a well-balanced manner.

[0035] [1.7 Optional Components] The oral composition of the present invention may optionally contain components other than components (A) to (E) as needed. Examples of optional components include surfactants, wetting agents, binders, solvents, sweeteners, medicinal components, oily components, preservatives, pH adjusters, and colorants (pigments). Optional components may be present individually or in combination of two or more.

[0036] - Surfactants (other than component (A)) - Any surfactant other than component (A) is acceptable, and examples include nonionic, amphoteric, and cationic surfactants.

[0037] Examples of nonionic surfactants include polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ethers, polyoxyethylene / polyoxypropylene alkyl ethers, glycerin fatty acid esters, polyglycerin fatty acid esters, alkyl glucosides, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters (e.g., polyoxyethylene sorbitan monostearate), fatty acid alkylolamides, polyoxyethylene fatty acid esters, polyoxyethylene alkenyl ethers, sucrose fatty acid esters (e.g., sucrose stearate esters), sugar alcohol fatty acid esters (e.g., maltitol fatty acid esters, lactitol fatty acid esters), polyoxyethylene polyoxypropylene copolymers, and polyoxyethylene polyoxypropylene fatty acid esters.

[0038] The average number of moles of ethylene oxide added to polyoxyethylene hydrogenated castor oil is preferably 5 to 100 moles, more preferably 5 to 60 moles. The number of carbon atoms in the alkyl chain of polyoxyethylene alkyl ether is preferably 10 to 26, and the average number of moles of ethylene oxide added is preferably 2 to 50 moles. The number of carbon atoms in the fatty acid of polyglycerin fatty acid ester is preferably 10 to 20. The average number of moles of ethylene oxide added to polyoxyethylene / polyoxypropylene alkyl ether is preferably 10 to 300 moles, the average number of moles of propylene oxide added is preferably 5 to 70 moles, and the number of carbon atoms in the alkyl group is preferably 10 to 20. The number of carbon atoms in the alkyl group of alkyl glucoside is preferably 8 to 20. The number of carbon atoms in the fatty acid of sucrose fatty acid ester is preferably 8 to 20. The number of carbon atoms in the fatty acid of sorbitan fatty acid ester is preferably 10 to 18. The number of carbon atoms in the fatty acid of polyoxyethylene sorbitan fatty acid ester is preferably 12 to 18, and the average number of moles of ethylene oxide added is preferably 20 to 80 moles. The number of carbon atoms in the alkyl chain of the fatty acid alkylolamide is preferably 8 to 20.

[0039] As the nonionic surfactant, polyoxyethylene hydrogenated castor oil is preferred, and polyoxyethylene hydrogenated castor oil with an average number of ethylene oxide additions of 5 to 100 moles, or 5 to 60 moles, is more preferred. The nonionic surfactant may be used alone or in combination of two or more types.

[0040] Examples of amphoteric surfactants include 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, N-lauroyl-N'-carboxymethyl-N'-hydroxyethylethylenediamine sodium, alkyldimethylaminoacetic acid betaine (e.g., lauryldimethylaminoacetic acid betaine), fatty acid amidopropyl betaine (e.g., coconut oil fatty acid amidopropyl betaine), lauryl imidazolinium betaine, alkyl sulfobetaine (e.g., lauramidopropyl hydroxysultaine), and lecithin. Of these, betaine-type amphoteric surfactants are preferred, fatty acid amidopropyl betaine is more preferred, and coconut oil fatty acid amidopropyl betaine is even more preferred. The amphoteric surfactant may be used alone or in combination of two or more types.

[0041] Examples of cationic surfactants include quaternary ammonium salt type cationic surfactants and amino acid-based cationic surfactants. Examples of quaternary ammonium salts include alkylpyridinium salts, benzethonium salts, benzalkonium salts, monoalkyltrimethylammonium salts, and dialkyldimethylammonium salts. Examples of salts include chloride salts and bromide salts. The number of carbon atoms in the alkyl and acyl groups that the cationic surfactant may have may be, for example, 8 to 22 or 9 to 21. Examples of quaternary ammonium salt type cationic surfactants include cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, stearyltrimethylammonium chloride, cetyltrimethylammonium chloride, behenyltrimethylammonium chloride, distearyldimethylammonium chloride, lauryldimethylbenzylammonium chloride, hexadecyltrimethylammonium bromide, and stearyltrimethylammonium bromide. Examples of amino acid-based cationic surfactants include mono-N-long-chain acyl basic amino acid lower alkyl ester salts. Examples of amino acids that may constitute a cationic surfactant include basic amino acids (e.g., natural amino acids such as ornithine, lysine, and arginine, and synthetic amino acids such as α,γ-diaminobutyric acid), and may be either optically active or racemic. The acyl group that the cationic surfactant may have is preferably a saturated or unsaturated higher fatty acid residue, such as a single higher fatty acid residue like a lauroyl group, myristoyl group, palmitoyl group, or stearoyl group; or a natural mixed higher fatty acid residue like coconut oil fatty acid residues or beef tallow higher fatty acid residues. Examples of lower alkyl esters include alkyl esters having 1 to 8 carbon atoms. Specifically, examples include methyl esters, ethyl esters, propyl esters, butyl esters, pentyl esters, hexyl esters, heptyl esters, and octyl esters.The lower alkyl ester is preferably in the form of a salt, specifically, inorganic salts such as hydrochloride, bromate, sulfate, phosphate, etc.; organic acid salts such as glycolate, acetate, lactate, succinate, tartrate, citrate, acidic amino acid salt, higher fatty acid salt, L- or DL-pyrrolidone carboxylate, pyroglutamate, p-toluenesulfonate, etc. Examples of the amino acid-based cationic surfactant include N-coconut oil fatty acid acyl-L-arginine ethyl DL-pyrrolidone carboxylate and the like. The cationic surfactant may be used alone or in combination of two or more.

[0042] The surfactant may be used alone or in combination of two or more. Further, it is preferable to contain a nonionic surfactant and an amphoteric surfactant, and it is more preferable to contain a nonionic surfactant and an amphoteric surfactant.

[0043] The content of the surfactant (other than (A)) is preferably 0.001% by mass or more, more preferably 0.01% by mass or more, and even more preferably 0.1% by mass or more. The upper limit is preferably 10% by mass or less, more preferably 8% by mass or less, and even more preferably 5% by mass or less. Therefore, it is preferably 0.001 to 10% by mass, more preferably 0.01 to 8% by mass, and even more preferably 0.1 to 5% by mass.

[0044] -Humectants- Examples of humectants include sugar alcohols and polyhydric alcohols other than sugar alcohols. Examples of sugar alcohols include sugar alcohols such as sorbitol, lactitol, and reduced starch saccharified products; glycerin; and polyhydric alcohols such as ethylene glycol, propylene glycol, dipropylene glycol, butylene glycol, and polyethylene glycol. Examples of polyethylene glycol include polyethylene glycol with an average molecular weight of 150 to 6000, preferably polyethylene glycol with an average molecular weight of 190 to 4000. Specifically, examples include PEG200, PEG300, PEG400, PEG600, and PEG4000. The average molecular weight is the average molecular weight described in the Quasi-Drug Raw Materials Standards 2021. One of the above humectants may be used alone, or two or more may be used in combination.

[0045] The content of the wetting agent is preferably 1 to 70% by mass, more preferably 1 to 65% by mass, even more preferably 1 to 60% by mass, and even more preferably 3 to 60% by mass, when the total amount of the oral composition is 100% by mass.

[0046] - Binding agents (other than components (B) and (D)) - Examples of binding agents include organic binding agents other than component (B). Examples of organic binding agents include polysaccharides, cellulosic binding agents (e.g., hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, methylcellulose, cationized cellulose, etc. and pharmaceutically acceptable salts thereof such as their sodium salts), other polysaccharide thickeners (e.g., guar gum, gellan gum, tragacanth gum, karaya gum, arabic gum, locust bean gum, carrageenan, sodium alginate), and synthetic water-soluble polymers (e.g., sodium polyacrylate, carboxyvinyl polymer, polyvinylpyrrolidone, polyvinyl alcohol, propylene glycol alginate). Binding agents may be used individually or in combination of two or more.

[0047] The content of the binder (excluding components (B) and (D)) is preferably 0.001% by mass or more, more preferably 0.01% by mass or more. The upper limit is preferably 10% by mass or less, more preferably 8% by mass or less, still more preferably 5% by mass or less, and even more preferably 3% by mass or less. Therefore, 0.001 to 10% by mass or less is preferable, 0.001 to 8% by mass is more preferable, 0.001 to 5% by mass is still more preferable, and 0.01 to 3% by mass is even more preferable.

[0048] - Solvent (excluding component (B)) - As the solvent (excluding component (B)), for example, lower monohydric alcohols such as ethyl alcohol (for example, having 1 to 4 carbon atoms) can be mentioned.

[0049] - Sweetener - As the sweetener, for example, saccharin, sodium saccharin, aspartame, stevioside, stevia extract, neohesperidin dihydrochalcone, perillartine, thaumatin, aspartylphenylalanine methyl ester, acesulfame potassium, maltitol, mannitol can be mentioned. The sweetener may be used alone or in combination of two or more.

[0050] -Medicinal Ingredients- Medicinal ingredients include, for example, fluorides such as sodium fluoride, potassium fluoride, sodium monofluorophosphate, and tin fluoride; hypersensitivity inhibitors such as potassium nitrate, aluminum lactate, and strontium chloride; amino acids such as alanine, pyrrolidone carboxylic acid or its salts (e.g., sodium salts), glycine, proline, arginine, lysine, glutamine, and cysteine; enzymes such as dextranase, amylase, protease, mutanase, laccase, lysozyme (lysozyme chloride), oxidase, peptidase, trypsin, papain, and lipase; tranexamic acid, allantoin, allantoin chlorohydroxyaluminum, ε-aminocaproic acid, azulene, sodium azulene sulfonate, glycyrrhizic acid or its salts (e.g., dipotassium glycyrrhizinate), and glycyrrhetinic acid or its salts (e.g., stearyl glycyrrhetinate). Examples include anti-inflammatory agents such as Phellodendron amurense and Phellodendron amurense extract; cell activators such as sodium chloride and vitamins; bactericidal or antibacterial agents such as isopropylmethylphenol, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, hinokitiol, thymol, lysozyme chloride, chlorhexidine, triclosan, zinc gluconate, and zinc citrate; water-soluble copper compounds such as copper chlorophyll and copper gluconate; tartar preventative agents such as zeolites, ethane hydroxydiphosphonate, and polyphosphates; coating agents such as hydroxyethylcellulose dimethyldiallylammonium chloride; vitamins such as vitamin C (e.g., ascorbic acid) and vitamin E (e.g., tocopherol or its derivatives), astringents such as sodium chloride, alum, and lysozyme chloride; peptides such as caropeptides; and plant extracts such as thyme, scutellaria baicalensis, clove, and witch hazel. If the oral composition contains medicinal ingredients, the amount may be an effective amount within a range that does not hinder the effects of the present invention (a range that is pharmacologically acceptable). The medicinal ingredients may be a single ingredient or a combination of two or more ingredients.

[0051] -Oily Components- Examples of oily components include hydrocarbons such as squalane, (light) liquid paraffin, petrolatum, and microcrystalline wax; higher alcohols (e.g., alcohols with 8 to 22 carbon atoms such as lauryl alcohol, cetyl alcohol, cetostearyl alcohol, oleyl alcohol, and isostearyl alcohol); higher fatty acids (e.g., fatty acids with 8 to 22 carbon atoms such as lauric acid, myristic acid, oleic acid, and isostearic acid); vegetable oils such as olive oil, castor oil, and coconut oil; and fatty acid esters such as isopropyl myristate. The oily components may be used individually or in combination of two or more types.

[0052] - Preservatives - Examples of preservatives include parahydroxybenzoic acid esters (e.g., methyl parahydroxybenzoate, ethyl parahydroxybenzoate, butyl parahydroxybenzoate), sodium benzoate, and methyl parahydroxybenzoic acid. Preservatives may be used individually or in combination of two or more.

[0053] - pH Adjusters - Examples of pH adjusters include organic acids such as phthalic acid, citric acid, succinic acid, tartaric acid, acetic acid, fumaric acid, malic acid, and lactic acid, or their salts (e.g., sodium citrate); inorganic acids such as phosphoric acid (e.g., orthophosphoric acid), or their salts (e.g., potassium salts, sodium salts, and ammonium salts); and hydroxides such as sodium hydroxide and potassium hydroxide. Examples of inorganic salts include disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium phosphate, sodium carbonate, and sodium bicarbonate. pH adjusters may be used individually or in combination of two or more.

[0054] -Coloring agents- As coloring agents, water-soluble dyes are preferred due to their high safety. Examples include Blue No. 1, Green No. 3, Yellow No. 4, Red No. 105, and Red No. 106.

[0055] Examples of other optional components include inorganic compounds such as zinc oxide, magnesium oxide, and zirconium oxide; natural polymer compounds such as agar, gelatin, starch, and glucomannan; synthetic polymer compounds or copolymers thereof such as polyvinyl acetate, acrylic resin, polyurethane, polyester, polyvinyl chloride, nylon powder, and polyethylene powder; waxes such as carnauba wax, rosin, rice wax, microcrystalline wax, beeswax, and paraffin wax; higher alcohols such as cetanol and stearyl alcohol; and polyisobutylene, polybutadiene, urethane, silicone, and natural rubber. The content of these other optional components can be appropriately set within a range that does not hinder the effects of the present invention.

[0056] [2. Dosage Forms and Uses of Oral Compositions] The dosage form of oral compositions is not particularly limited. Examples of dosage forms include liquids (solutions, emulsions, suspensions, syrups, etc.), semi-solids (gels, creams, pastes, etc.), and solids (tablets, particulates, capsules, films, kneads, molten solids, waxy solids, elastic solids, soft capsules, etc.). Preferably, oral compositions are in liquid or semi-solid form.

[0057] Oral compositions can be widely used in various oral applications such as foods, quasi-drugs, and cosmetics. Examples of solid dosage forms include lozenges, gummies, gums, and toothpastes. Examples of semi-solid dosage forms include toothpastes and gel toothpastes. Examples of liquid dosage forms include mouthwashes, liquid toothpastes, and oral fresheners (sprays, etc.).

[0058] The pH of the oral composition (at 25°C) is preferably near neutral, and more preferably between 5 and 9. The pH can be adjusted by adding a pH adjusting agent, changing the component composition, etc.

[0059] The viscosity of oral compositions can be adjusted according to the dosage form and application. For example, in the case of semi-solid form, a viscosity of 20 to 150 Pa·s at 25°C, as measured with a BH viscometer, is preferred. In the case of liquid form, the viscosity is preferably 30 mPa·s or less, and more preferably 0.7 to 30 mPa·s.

[0060] [Method for Manufacturing Oral Compositions] The method for manufacturing the oral composition of the present invention is not particularly limited. In the case of toothpaste compositions, for example, one manufacturing method involves preparing components soluble in a solvent, mixing insoluble components, and if necessary, removing foam by, for example, reducing pressure, before placing the mixture in a container.

[0061] The shape and material of the container are not particularly limited. Examples of container materials include plastic containers made of polyethylene, polypropylene, polyethylene terephthalate, and nylon. In the case of toothpaste, a laminate tube is preferred, and in the case of liquid preparations, a container (bottle) capable of holding the liquid is preferred.

[0062] The present invention will be described in detail below with reference to examples. The following examples are one embodiment of the present invention and are not intended to limit it.

[0063] Examples 1-16 and Comparative Examples 1-7 [Sample Preparation] The raw materials shown in Tables 1-3 were blended by conventional methods to obtain toothpaste compositions. The obtained toothpaste compositions were then placed in conventionally known and suitable containers (laminated tubes). The obtained toothpaste compositions were evaluated by the following methods.

[0064] [Evaluation Method] (1) Evaluation of Oil Separation A toothpaste composition filled in an 8 mm diameter laminate tube was stored in a constant temperature bath at 50°C for one month. Holding the center of the laminate tube filled with the toothpaste composition, the majority of the contents of the laminate tube were smoothly squeezed out onto a stability test sheet to a length of approximately 15 cm. The state of oil separation in the toothpaste composition at the time of squeezing was evaluated according to the following evaluation criteria. (Evaluation Criteria) A: No liquid separation is observed B: Liquid separation is observed in a very small area, but at a level that does not affect quality C: Liquid separation is observed

[0065] (2) Evaluation of stringiness The stringiness of the toothpaste composition was tested by placing approximately 1 g of the toothpaste composition, which was filled into an 8 mm diameter laminate tube, onto a toothbrush, and then pulling the laminate tube and toothbrush upwards. Stringiness refers to the property of the toothpaste composition to stretch like a string when removed from a container such as a tube, and is an indicator of how well the toothpaste composition can be mixed. The length of the stretched string was measured and evaluated according to the following criteria. (Evaluation criteria) A: The length of the stretched string is less than 0.5 cm, indicating good mixing ability B: The length of the stretched string is 0.5 cm or more but less than 1.0 cm, but this is at a level that does not cause problems in use C: The length of the stretched string is 1.0 cm or more, indicating problems in use

[0066] (3) Evaluation of foam volume (evaluation of low foaming properties) The evaluation was conducted by a sensory test conducted by four expert panelists as subjects. 1 g of the toothpaste composition was placed on a toothbrush, brushed for 2 minutes, and rinsed once with water. The amount of foam during brushing was evaluated on a 5-point scale according to the scoring criteria shown below. The average score of the four subjects was calculated and shown in the table as A, B, and C according to the following evaluation criteria. (Scoring Criteria) 5: Excellent 4: Good 3: Fair 2: Not very good 1: Poor (Evaluation Criteria) A: 4 points or more B: 3 points or more but less than 4 points C: Less than 3 points

[0067]

[0068]

[0069]

[0070] [Footnotes to the table (*)] Sodium carboxymethylcellulose: Sunrose (registered trademark) F20HC, manufactured by Nippon Paper Industries, carboxymethyl substitution degree 0.8-1.0 Inorganic silicic acid (abrasive silica): Zeodent (registered trademark)-115, manufactured by Evonik, average particle size (D50) 10 μm, oil absorption 105 mL / 100 g Inorganic silicic acid (thickening silica): Zeodent (registered trademark)-165, manufactured by Evonik, average particle size (D50) 12 μm Titanium dioxide: CR-50, manufactured by Ishihara Sangyo Co., Ltd., average particle size 0.25 μm Fragrance: as per the formulation in Table 4 below

[0071]

[0072] Comparative Examples 1 to 6, which contained components (A) to (E) but whose respective content of components (A) to (C) did not meet one of the following criteria: 0.1 to 1.0% by mass, 1 to 35% by mass, or 0.01 to 2.0% by mass, showed poor evaluation in either oil separation, stringiness, or foam volume. Similarly, Comparative Example 7, which did not contain component (D) and whose content of component (B) exceeded 35% by mass, also showed poor evaluation in stringiness and foam volume. In contrast, Examples 1 to 16, which contained components (A) to (E) and whose content of components (A) to (C) was within the predetermined range, all showed well-balanced and good evaluations in all aspects: oil separation, stringiness, and foam volume. These results indicate that the oral composition of the present invention can suppress the separation and expression of oily components such as fragrance-derived oils, suppress the development of stringiness, and exhibit an appropriate amount of foam.

Claims

1. An oral composition comprising: (A) an anionic surfactant, (B) water, (C) xanthan gum and / or carboxymethylcellulose, (D) inorganic powder, and (E) fragrance, wherein the content of (A), (B), and (C) is 0.1 to 1.0% by mass, 1 to 35% by mass, and 0.01 to 2.0% by mass, respectively.

2. The oral composition according to claim 1, wherein the mass ratio ((A) / ((B)+(C)) of the content of component (A) to the total content of components (B) and (C) is 0.001 to 0.

6.

3. The oral composition according to claim 1 or 2, wherein the mass ratio of the content of component (D) to the total content of components (B) and (C) ((D) / ((B)+(C))) is 0.0015 to 11.

4. The oral composition according to any one of claims 1 to 3, wherein the content of component (D) is 1 to 20% by mass.

5. The oral composition according to any one of claims 1 to 4, wherein the content of component (E) with logP less than 3 relative to the entire oral composition is 0.8% by mass or less.

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