Dry powder inhaler with integrated desiccant

Abstract

Dry powder inhalers and methods of manufacturing the same are described. A dry powder inhaler includes a desiccant containing desiccant beads and a protective layer to maintain efficacy of the desiccant beads, an overcap formed to integrally hold the desiccant, a medicant dispensing component containing a dry powder medicant, and where one of the protective layer and the medicant dispensing component includes a piercing mechanism. Attachment of the overcap to the medicant dispensing component causes the piercing mechanism to tear the protective layer and place the desiccant beads in dry powder communication with the dry powder medicant, enabling the desiccant beads to absorb moisture present in the dry powder inhaler.

Description

Attorney Docket No. JABIN-123-B-WODRY POWDER INHALER WITH INTEGRATED DESICCANTTECHNICAL FIELD

[0001] This disclosure relates to dry powder inhalers and in particular, use of a desiccant system to maintain dry ness of the dry' powder, drug product, or medicant in the dry' powder inhaler.BACKGROUND

[0002] Dry' powder inhalers are used to dispense medicant in the form of a dry' powder to a user. Dry powder is susceptible to absorbing moisture and other unwanted materials. This can increase cohesion between the dry powder particles. The dry powder particles can clump and agglomerate into large particles. This can hamper the ability to inhale the medicant and reduce the effectiveness of the dry' powder inhaler and the medicant. Therefore, the dry' powder needs to be kept as dry' as possible.SUMMARY

[0003] Disclosed herein are implementations of a dry powder inhaler with an integrated desiccant. In implementations, a dry' pow der inhaler includes a desiccant containing desiccant beads and a protective layer to maintain efficacy of the desiccant beads, an overcap formed to integrally hold the desiccant, a medicant dispensing component containing a dry powder medicant, and where one of the protective layer and the medicant dispensing component includes a piercing mechanism. Attachment of the overcap to the medicant dispensing component causes the piercing mechanism to tear the protective layer and place the desiccant beads in dry powder communication with the dry powder medicant, enabling the desiccant beads to absorb moisture present in the dry powder inhaler.BRIEF DESCRIPTION OF THE DRAWINGS

[0004] The disclosure is best understood from the following detailed description when read in conjunction with the accompanying drawings and are incorporated into and thus constitute a part of this specification. It is emphasized that, according to common practice, the various features of the drawings are not to-scale. On the contrary7, the dimensions of the various features are arbitrarily expanded or reduced for clarity.

[0005] FIG. 1 is a cross-sectional view of a desiccant in accordance with certain implementations.Attorney Docket No. JABIN-123-B-WO

[0006] FIG. 2 is a cross-sectional view of an integrated and / or assembled overcap with the desiccant in accordance with certain implementations.

[0007] FIG. 3 is a side view of a medicant dispensing component in accordance with certain implementations.

[0008] FIG. 4 is a partial cross-sectional and side view of a dry powder inhaler with an integrated overcap attached to a medicant dispensing component in accordance with certain implementations

[0009] FIG. 5 is a flow diagram of an example of a method for manufacturing a dry powder inhaler with an integrated desiccant in accordance with certain implementations.DETAILED DESCRIPTION

[0010] The figures and descriptions provided herein can be simplified to illustrate aspects of the described embodiments that are relevant for a clear understanding of the herein disclosed processes, devices, machines, manufactures, and / or compositions of matter, while eliminating for the purpose of clarity other aspects that can be found in typical similar devices, systems, compositions, and methods. Those of ordinary skill can thus recognize that other elements and / or steps can be desirable or necessary to implement the devices, systems, compositions, and methods described herein. However, because such elements and steps are well know n in the art, and because they do not facilitate a better understanding of the disclosed embodiments, a discussion of such elements and steps may not be provided herein. However, the present disclosure is deemed to inherently include all such elements, variations, and modifications to the described aspects that would be known to those of ordinary skill in the pertinent art in light of the discussion herein.

[0011] Embodiments are provided throughout so that this disclosure is sufficiently thorough and fully conveys the scope of the disclosed embodiments to those who are skilled in the art. Numerous specific details are set forth, such as examples of specific aspects, devices, and methods, to provide a thorough understanding of embodiments of the present disclosure. Nevertheless, it will be apparent to those skilled in the art that certain specific disclosed details need not be employed, and that embodiments may be embodied in different forms. As such, the exemplary embodiments set forth should not be construed to limit the scope of the disclosure.

[0012] The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting. For example, as used herein, the singular forms “a”, "an" and “the” may be intended to include the plural forms as well, unless theAttorney Docket No. JABIN-123-B-WO context clearly indicates otherwise. The terms “comprises,” “comprising,” “including,” and “having,” are inclusive and therefore specify the presence of stated features, steps, operations, elements, and / or components, but do not preclude the presence or addition of one or more other features, steps, operations, elements, components, and / or groups thereof.

[0013] The steps, processes, and operations described herein are thus not to be constmed as necessarily requiring their respective performance in the particular order discussed or illustrated, unless specifically identified as a preferred or required order of performance. It is also to be understood that additional or alternative steps may be employed, in place of or in conjunction with the disclosed aspects.

[0014] Yet further, although the terms first, second, third, etc. may be used herein to describe various elements, steps, or aspects, these elements, steps, or aspects should not be limited by these terms. These terms may be only used to distinguish one element or aspect from another. Thus, terms such as “first,” “second,” and other numerical terms when used herein do not imply a sequence or order unless clearly indicated by the context. Thus, a first element, step, component, region, layer, or section discussed below could be termed a second element, step, component, region, layer, or section without departing from the teachings of the disclosure.

[0015] As used herein, the terminology “determine” and “identify,” or any variations thereof includes selecting, ascertaining, computing, looking up, receiving, determining, establishing, obtaining, or otherwise identifying or determining in any manner whatsoever using one or more of the devices and methods are shown and described herein.

[0016] As used herein, the terminology “example,” “the embodiment,” “implementation,” “aspect,” “feature,” or “element” indicates serving as an example, instance, or illustration. Unless expressly indicated, any example, embodiment, implementation, aspect, feature, or element is independent of each other example, embodiment, implementation, aspect, feature, or element and may be used in combination with any other example, embodiment, implementation, aspect, feature, or element.

[0017] As used herein, the terminology “or” is intended to mean an inclusive “or” rather than an exclusive “or.” That is unless specified otherwise, or clear from context, “X includes A or B” is intended to indicate any of the natural inclusive permutations. That is if X includes A; X includes B; or X includes both A and B, then “X includes A or B” is satisfied under any of the foregoing instances. In addition, the articles “a” and “an” as used in this application and the appended claims should generally be construed to mean “one or more” unless specified otherwise or clear from the context to be directed to a singular form.Attorney Docket No. JABIN-123-B-WO

[0018] Disclosed herein are implementations of a dry powder inhaler with an integrated desiccant system. In implementations, the dry powder inhaler can include a medicant dispensing component, an overcap or closure system, and the desiccant. In implementations, the desiccant can include a desiccant housing for holding or placement of silica beads, activated charcoal, carbon, carbon fiber, calcium sulfate, calcium chloride, molecular sieves, and / or other types of desiccant beads (collectively “desiccant beads and / or material”), a plastic mesh for maintaining the desiccant beads in the desiccant housing, a cardboard layer or moisture exchange layer for enabling moisture exchange, and a pierceable film layer for maintaining the dryness of the desiccant beads prior to use. In implementations, the overcap or closure (collectively “overcap”) can be formed and / or molded to integrate, enclose, and / or attach the desiccant to the overcap to form an integrated overcap. In implementations, the medicant dispensing component can include medicant and a piercing, breaking, and / or removal component (collectively “piercing component or mechanism”). In implementations, the integrated overcap can be attached to the medicant dispensing component such that the piercing component can pierce and / or break and / or remove the pierceable film layer. The desiccant beads are then in an absorbing communication and / or in an absorbing pathway with the medicant.

[0019] FIG. 1 is a cross-sectional view of a desiccant 1000 in accordance with certain implementations. In implementations, the desiccant 1000 can include a desiccant housing 1100 configured to maintain desiccant beads 1200. The desiccant housing 1100 can be made of plastic and / or other materials suitable for holding the desiccant beads 1200. The size and shape of the desiccant housing 1100 can be configured in accordance with the application and / or application device. In a non-limiting example, the application and / or application device can be a dry powder inhaler.

[0020] In implementations, a containment layer and / or mesh 1300 can be bonded, fused, welded, and / or attached (“fused”) to an internal surface 1110 of a sidewall 1120 of the desiccant housing 1100 to seal the desiccant beads 1200 in the desiccant housing 1100. The mesh 1300 can include openings 1310 which are smaller than the size of the desiccant beads 1200. The mesh 1300 can be made of plastic and / or other suitable materials.

[0021] In implementations, a moisture exchange layer 1400 can be fused to the internal surface 1110 to enable moisture exchange between the desiccant beads 1200 and a dry powder that is to be kept dry. The moisture exchange layer 1400 can be made from cardboard, molded fiber, pulp, and / or suitable materials that permit osmosis as between the desiccant beads 1200 and the dry powder. In implementations, the mesh 1300 and the moisture exchange layer 1400Attorney Docket No. JABIN-123-B-WO can be an integrated layer.

[0022] In implementations, a pierceable, removable, and / or breakable protective film, lid and / or layer 1500 can be fused to the internal surface 1110 to protect and maintain the efficacy of the desiccant beads 1200 prior to use with the application and / or application device. The pierceable film layer 1500 can be a plastic film and / or other suitable materials that prevent moisture from affecting the desiccant beads 1200. In implementations, a surface 1510 of the pierceable film layer 1500 can include an adhesive to enable breaking of the pierceable film layer 1500 when the desiccant 1000 is attached to and / or used with the application and / or application device.

[0023] As noted herein, in implementations, the application and / or application device is a dry powder inhaler. The dry powder inhaler can include, but is not limited to, an overcap and a medicant dispensing component. Described herein is integration of the desiccant 1000 with the dry powder inhaler.

[0024] FIG. 2 is a cross-sectional view of an assembled and / or integrated overcap 2000 with the desiccant 1000 in accordance with certain implementations. In implementations, the integrated overcap 2000 can include an overcap 2100 and the desiccant 1000. In implementations, the overcap 2100 can be molded, overmolded, and / or otherwise formed to attach the desiccant 1000 in a desiccant holding portion 2110 of the overcap 2100 such that the pierceable film layer 1500 is left exposed to a medicant dispensing component holding portion 2120. In implementations, the overcap 2100 can include a medicant dispensing component attachment component 2130 on an internal surface 2122 of a sidewall 2124 of the medicant dispensing component holding portion 2120. The overcap 2100 can be made from plastic and / or other suitable materials.

[0025] FIG. 3 is a side view of a medicant dispensing component 3000 in accordance with certain implementations. In implementations, the medicant dispensing component 3000 can include, but is not limited to, an upper or mouthpiece component 3100 which is in dry powder communication with a medicant container component 3200.

[0026] In implementations, the medicant container component 3200 can hold dry powder 3300. For example, the dry powder is a medicant in dry powder form. In implementations, the medicant container component 3200 can include, but is not limited to, a counter 3210 and a medicant container component attachment component 3220. The medicant container component attachment component 3220 can match for engagement with the medicant dispensing component attachment component 2130 of the integrated overcap 2000. In implementations, the medicant container component attachment component 3220 and theAttorney Docket No. JABIN-123-B-WO medicant dispensing component attachment component 2130 can be, but is not limited to, a screw-type fit, an interference fit, a snap-fit, and / or combinations thereof. The counter 3210 can display, for example, a remaining number of dosages available of the medicant in the dry powder inhaler.

[0027] In implementations, the upper or mouthpiece component 3100 can include, but is not limited to, one or more dry powder dispensing apertures and / or openings 3110 and a piercing mechanism 3120. The one or more dry powder dispensing apertures and / or openings 3110 enable dispensing of the dry powder 3300 (e.g., medicant) to a user using the dry powder inhaler.

[0028] In implementations, the piercing mechanism 3120 are configured to pierce the pierceable film layer 1500 when the integrated overcap 2000 is attached to the medicant dispensing component 3000 using the medicant container component attachment component 3220 and the medicant dispensing component attachment component 2130 of the integrated overcap 2000. In implementations, the piercing mechanism 3120 can be teeth and / or projections on a surface 3130 which would face and tear the pierceable film layer 1500 when the integrated overcap 2000 is attached to the medicant dispensing component 3000. In implementations, the piercing mechanism 3120 can be made of plastic and / or other materials. In implementations, the piercing mechanism 3120 can be made molded onto the surface 3130. In implementations, the piercing mechanism 3120 can be one or more protrusions on the surface 3130. In implementations, one or more protrusions can be molded on the surface 3130. In implementations, the piercing mechanism 3120 can degrade, disintegrate, and / or disappear over time as they are not needed once the pierceable film layer 1500 is broken.

[0029] In implementations, the piercing mechanism 3120 can be an adhesive on the surface 3130 which can engage and tear the pierceable, removable, and / or breakable film layer 1500 when the integrated overcap 2000 is attached to the medicant dispensing component 3000. In implementations, one of the pierceable film layer 1500 or the mouthpiece component 3100 can have the adhesive to create and / or establish a tacky surface which would be engaged by the other of the pierceable film layer 1500 or the mouthpiece component 3100. In implementations, both of the pierceable film layer 1500 and the mouthpiece component 3100 can have the adhesive to create and / or establish tacky surfaces which would be engaged by each other to tear the pierceable film layer 1500.

[0030] FIG. 4 is a partial cross-sectional and side view of a dry powder inhaler 4000 with the integrated overcap 2000 attached to the medicant dispensing component 3000 in accordance with certain implementations. In implementations, the dry powder inhaler 4000 canAttorney Docket No. JABIN-123-B-WO include, but is not limited to, the integrated overcap 2000 and the medicant dispensing component 3000 as described herein.

[0031] Operationally, when the integrated overcap 2000 is attached to the medicant dispensing component 3000, the pierceable film layer 1500 can be broken and / or tom as described herein. Once the pierceable film layer 1500 is tom, the desiccant beads 1200 are now in dry powder communication and / or in a dry powder pathway with the dry powder 3300. The desiccant beads 1200 can then assist in maintaining the dryness of the dry powder 3300 and / or maintaining a moisture free environment.

[0032] FIG. 5 is a flow diagram of an example of a method 5000 for manufacturing a dry powder inhaler with an integrated desiccant in accordance with certain implementations. The method 5000 can be used to make the desiccant, the dry powder inhaler and / or components described in FIGS 1-4. The method 5000 includes forming 5100 a desiccant; integrating 5200 the desiccant with an overcap; forming 5300 a medicant dispensing component; and puncturing and / or tearing 5400 a protective film by attachment of an integrated overcap with the medicant dispensing component.

[0033] The method 5000 includes forming 5100 a desiccant. The desiccant can include, but is not limited to, a housing for holding desiccant beads and / or materials, a containment layer for sealing the desiccant beads in the housing, a moisture exchange layer for enabling moisture absorption by the desiccant beads, and a tearable protective layer for protecting and / or enhancing freshness, efficacy, or operability of the desiccant beads. In implementations, an external facing surface of the tearable protective layer can be established with a tacky or sticky surface to assist in tearing of the tearable protective layer.

[0034] The method 5000 includes integrating 5200 the desiccant with an overcap. An overcap is molded to include the desiccant in a first portion of the overcap to form an integrated overcap. In implementations, the overcap can include a second portion and attachment mechanisms to cover and attach to a medicant dispensing component.

[0035] The method 5000 includes forming 5300 a medicant dispensing component. A medicant dispensing component can include a mouthpiece in communication with a dry powder container. In implementations, the medicant dispensing component can include a piercing mechanism, piercing elements, and / or a tacky surface configured and / or positioned to pierce and / or tear the tearable protective layer. In implementations, the piercing mechanism on the protection layer is an adhesive-based tacky layer. In implementations, the protective layer and the medicant dispensing component includes the piercing mechanism, which is an adhesive-based tacky layer.Attorney Docket No. JABIN-123-B-WO

[0036] The method 5000 includes puncturing and / or tearing 5400 a protective film by attachment of an integrated overcap with the medicant dispensing component. The attachment of the integrated overcap to the medicant dispensing component causes the protective film to puncture and / or tear. This places the desiccant beads in dry powder communication with the dry powder in the dry powder container, enabling the desiccant beads to absorb the moisture in the environment, in the dry powder, and / or in the dry powder inhaler.

[0037] Described herein is a non-limiting illustration of a dry powder inhaler. The dry powder inhaler includes a desiccant containing desiccant beads and a protective layer to maintain efficacy of the desiccant beads, an overcap formed to integrally hold the desiccant, and a medicant dispensing component containing a dry powder medicant, where one of the protective layer and the medicant dispensing component includes a piercing mechanism, and where attachment of the overcap to the medicant dispensing component causes the piercing mechanism to tear the protective layer and place the desiccant beads in dry powder communication with the dry powder medicant, enabling the desiccant beads to absorb moisture present in the dry powder inhaler.

[0038] In implementations, the desiccant further includes a desiccant housing to hold the desiccant beads, and a containment layer to maintain the desiccant beads in the desiccant housing. In implementations, the containment layer is a mesh which includes openings sized smaller than a size of the desiccant beads. In implementations, the desiccant further includes a moisture exchange layer to enable moisture absorption by the desiccant beads. In implementations, the containment layer and the moisture exchange layer are integrated. In implementations, the piercing mechanism on the protection layer is an adhesive-based tacky layer. In implementations, the piercing mechanism on the medicant dispensing component is an adhesive-based tacky layer. In implementations, both the protective layer and the medicant dispensing component includes the piercing mechanism, which is an adhesive-based tacky layer. In implementations, the piercing mechanism on the medicant dispensing component is one or more protrusions. In implementations, the one or more protrusions are molded on the medicant dispensing component. In implementations, the one or more protrusions disintegrate after piercing of the protective layer.

[0039] Described herein is a non-limiting illustration of method for manufacturing a dry powder inhaler. The method includes forming a desiccant containing desiccant beads and a pierceable protective film, integrating the desiccant with an overcap to form an integrated overcap, forming a medicant dispensing component containing dry powder medicant. wherein one of pierceable protective film and the medicant dispensing component includes a tearingAttorney Docket No. JABIN-123-B-WO mechanism, and tearing by the tearing mechanism the protective film by attachment of the integrated overcap with the medicant dispensing component, wherein the desiccant beads are thereby in dry powder communication with the dry powder medicant to enable the desiccant beads to absorb moisture present in the dry powder inhaler.

[0040] In implementations, the forming a desiccant further includes placing the desiccant beads in a desiccant housing, and sealing the desiccant beads with a mesh layer, wherein the mesh layer includes openings sized smaller than a size of the desiccant beads. In implementations, the forming a desiccant further includes establishing a moisture exchange layer in the desiccant housing to enable moisture absorption by the desiccant beads. In implementations, the mesh layer and the moisture exchange layer are integrated. In implementations, the tearing mechanism on the pierceable protective film is an adhesive-based tacky layer. In implementations, the tearing mechanism on the medicant dispensing component is an adhesive-based tacky layer. In implementations, both the protective film and the medicant dispensing component includes the tearing mechanism, which is an adhesive-based tacky' layer. In implementations, the tearing mechanism on the medicant dispensing component is one or more protrusions and wherein the forming a medicant dispensing component further includes molding the one or more protrusions on the medicant dispensing component. In implementations, the one or more protrusions disintegrate after piercing of the pierceable protective film.

[0041] The construction and arrangement of the methods as shown in the various exemplary embodiments are illustrative only. Although only a few embodiments have been described in detail in this disclosure, many modifications are possible (e.g., variations in sizes, dimensions, structures, shapes and proportions of the various elements, values of parameters, mounting arrangements, use of materials and components, colors, orientations, etc.). For example, the position of elements can be reversed or otherwise varied and the nature or number of discrete elements or positions can be altered or varied. Accordingly, all such modifications are intended to be included within the scope of the present disclosure. The order or sequence of any process or method steps can be varied or re-sequenced according to alternative embodiments. Other substitutions, modifications, changes, and omissions can be made in the design, operating conditions, and arrangement of the exemplar}' embodiments without departing from the scope of the present disclosure.

[0042] Although the figures can show a specific order of method steps, the order of the steps can differ from what is depicted. Also two or more steps can be performed concurrently or with partial concurrence. Such variation will depend on the software and hardware systemsAttorney Docket No. JABIN-123-B-WO chosen and on designer choice. All such variations are within the scope of the disclosure. Likewise, software implementations could be accomplished with standard programming techniques with rule-based logic and other logic to accomplish the various connection steps, processing steps, comparison steps, and decision steps.

[0043] Persons skilled in the art will understand that the various embodiments of the present disclosure and shown in the accompanying figures constitute non-limiting examples, and that additional components and features may be added to any of the embodiments discussed hereinabove without departing from the scope of the present disclosure.Additionally, persons skilled in the art will understand that the elements and features shown or described in connection with one embodiment may be combined with those of another embodiment without departing from the scope of the present disclosure to achieve any desired result and will appreciate further features and advantages of the presently disclosed subject matter based on the description provided. Variations, combinations, and / or modifications to any of the embodiments and / or features of the embodiments described herein that are within the abilities of a person having ordinary skill in the art are also within the scope of the present disclosure, as are alternative embodiments that may result from combining, integrating, and / or omitting features from any of the disclosed embodiments.

[0044] Use of the term “optionally” with respect to any element of a claim means that the element may be included or omitted, with both alternatives being within the scope of the claim. Additionally, use of broader terms such as “comprises,” “includes,” and “having” should be understood to provide support for narrower terms such as “consisting of,” “consisting essentially of,” and “comprised substantially of.” Accordingly, the scope of protection is not limited by the description set out above, but is defined by the claims that follow, and includes all equivalents of the subject matter of the claims.

[0045] In the preceding description, reference may be made to the spatial relationship between the various structures illustrated in the accompanying drawings, and to the spatial orientation of the structures. However, as will be recognized by those skilled in the art after a complete reading of this disclosure, the structures described herein may be positioned and oriented in any manner suitable for their intended purpose. Thus, the use of terms such as “above,” “below,” “upper,” “lower,” “inner,” “outer,” “left,” “right,” “upward,” “downward,” “inward,” “outward,” “horizontal,” “vertical,” etc., should be understood to describe a relative relationship between the structures and / or a spatial orientation of the structures. Those skilled in the art will also recognize that the use of such terms may be provided in the context of the illustrations provided by the corresponding figure(s).Attorney Docket No. JABIN-123-B-WO

[0046] Additionally, terms such as “approximately,” “generally,” “substantially,” and the like should be understood to allow for variations in any numerical range or concept with which they are associated and encompass variations on the order of 25% (e.g., to allow for manufacturing tolerances and / or deviations in design). For example, the term “generally parallel” should be understood as referring to configurations in with the pertinent components are oriented so as to define an angle therebetween that is equal to 180° ± 25% (e.g., an angle that lies within the range of (approximately) 135° to (approximately) 225°). The term “generally parallel” should thus be understood as referring to encompass configurations in which the pertinent components are arranged in parallel relation.

[0047] While the disclosure has been described in connection with certain embodiments, it is to be understood that the disclosure is not to be limited to the disclosed embodiments but, on the contrary, is intended to cover various modifications and equivalent arrangements included within the scope of the appended claims, which scope is to be accorded the broadest interpretation so as to encompass all such modifications and equivalent structures as is permitted under the law.

Claims

Attorney Docket No. JABIN-123-B-WOWhat is claimed is:

1. A dry powder inhaler, comprising: a desiccant containing desiccant beads and a protective layer to maintain efficacy of the desiccant beads; an overcap formed to integrally hold the desiccant; and a medicant dispensing component containing a dry powder medicant, wherein one of the protective layer and the medicant dispensing component includes a piercing mechanism, and wherein attachment of the overcap to the medicant dispensing component causes the piercing mechanism to tear the protective layer and place the desiccant beads in dry powder communication with the dry powder medicant, enabling the desiccant beads to absorb moisture present in the dry powder inhaler.

2. The dry powder inhaler of claim 1, wherein the desiccant further comprises: a desiccant housing to hold the desiccant beads; and a containment layer to maintain the desiccant beads in the desiccant housing.

3. The dry powder inhaler of claim 2, wherein the containment layer is a mesh which includes openings sized smaller than a size of the desiccant beads.

4. The dry powder inhaler of claim 2, wherein the desiccant further comprises: a moisture exchange layer to enable moisture absorption by the desiccant beads.

5. The dry powder inhaler of claim 4, wherein the containment layer and the moisture exchange layer are integrated.

6. The dry powder inhaler of claim 1, wherein the piercing mechanism on the protection layer is an adhesive-based tacky layer.

7. The dry powder inhaler of claim 1, wherein the piercing mechanism on the medicant dispensing component is an adhesive-based tacky layer.

8. The dry powder inhaler of claim 1, wherein both the protective layer and the medicantAttorney Docket No. JABIN-123-B-WO dispensing component includes the piercing mechanism, which is an adhesive-based tacky- layer.

9. The dry7powder inhaler of claim 1, wherein the piercing mechanism on the medicant dispensing component is one or more protrusions.

10. The dry powder inhaler of claim 9, wherein the one or more protrusions are molded on the medicant dispensing component.

11. The dry powder inhaler of claim 9, wherein the one or more protrusions disintegrate after piercing of the protective layer.

12. A method for manufacturing a dry7powder inhaler, the method comprising: forming a desiccant containing desiccant beads and a pierceable protective fdm; integrating the desiccant with an overcap to form an integrated overcap; forming a medicant dispensing component containing dry powder medicant, wherein one of pierceable protective fdm and the medicant dispensing component includes a tearing mechanism; and tearing by the tearing mechanism the protective fdm by attachment of the integrated overcap with the medicant dispensing component, wherein the desiccant beads are thereby in dry powder communication with the dry powder medicant to enable the desiccant beads to absorb moisture present in the dry7powder inhaler.

13. The method of claim 12, wherein the forming a desiccant further comprises: placing the desiccant beads in a desiccant housing; and sealing the desiccant beads with a mesh layer, wherein the mesh layer includes openings sized smaller than a size of the desiccant beads.

14. The method of claim 13, wherein the forming a desiccant further comprises: establishing a moisture exchange layer in the desiccant housing to enable moisture absorption by the desiccant beads.

15. The method of claim 14, wherein the mesh layer and the moisture exchange layer are integrated.Attorney Docket No. JABIN-123-B-WO16. The method of claim 12. wherein the tearing mechanism on the pierceable protective film is an adhesive-based tacky layer.

17. The method of claim 12, wherein the tearing mechanism on the medicant dispensing component is an adhesive-based tacky layer.

18. The method of claim 12, wherein both the protective film and the medicant dispensing component includes the tearing mechanism, which is an adhesive-based tacky layer.

19. The method of claim 12. wherein the tearing mechanism on the medicant dispensing component is one or more protrusions and wherein the forming a medicant dispensing component further comprises: molding the one or more protrusions on the medicant dispensing component.

20. The method of claim 19, wherein the one or more protrusions disintegrate after piercing of the pierceable protective film.

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