Ta / HAMA-PBA / pnipam smart responsive hydrogel, and preparation method therefor and use thereof
By preparing a TA/HAMA-PBA/PNIPAM smart responsive hydrogel, and utilizing the interpenetrating network of HAMA-PBA and PNIPAM and the thermosensitivity of PNIPAM, the problem of traditional hydrogels sliding on the moist liver surface is solved. This enables controlled drug release and antibacterial hemostasis of liver wounds, and has self-healing capabilities, making it suitable for minimally invasive treatment of liver wounds.
WO2026144439A1PCT designated stage Publication Date: 2026-07-09NANJING DRUM TOWER HOSPITAL
Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- NANJING DRUM TOWER HOSPITAL
- Filing Date
- 2025-10-23
- Publication Date
- 2026-07-09
AI Technical Summary
Technical Problem
Traditional hydrogels tend to slide on the moist surface of the liver and lack controllable drug release capabilities, which limits their effectiveness in liver wound repair.
Method used
The TA/HAMA-PBA/PNIPAM smart responsive hydrogel is used. HAMA-PBA and PNIPAM form an interpenetrating network structure, and TA molecules are grafted through borate ester bonds. Combined with the thermosensitivity of PNIPAM, it achieves controlled drug release and adhesive hemostasis.
Benefits of technology
It achieves controlled drug release, antibacterial hemostasis, and wound repair at the liver wound site, possesses self-healing ability, is suitable for minimally invasive treatment, and reduces intraoperative and postoperative complications.
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Smart Images
Figure CN2025129438_09072026_PF_FP_ABST
Abstract
Disclosed in the present invention is a TA / HAMA-PBA / PNIPAM smart responsive hydrogel, comprising an HAMA-PBA polymer as a matrix, a PNIPAM polymer as a temperature-sensitive network, and a TA molecule as a crosslinker. Further disclosed in the present invention is a method for preparing the TA / HAMA-PBA / PNIPAM smart responsive hydrogel, which method comprises the steps of mixing and dissolving raw materials, preparing a precursor solution, and crosslinking. Further disclosed in the present invention is the use of the TA / HAMA-PBA / PNIPAM smart responsive hydrogel. The smart responsive hydrogel provided in the present invention has good antibacterial properties, and hemostatic and wound repair capabilities. The method for preparing the smart responsive hydrogel provided in the present invention is simple, broadly applicable, and suitable for large-scale production. The smart responsive hydrogel provided in the present invention has hemostatic effects, enables minimally invasive treatment for preventing wound infection, and provides controlled local drug release for repairing damaged sites and wound sites.
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