Reaction cup clearing method, mode selection method, and chemiluminescence immunoassay analyzer

Abstract

A reaction cup clearing method, a mode selection method, and a chemiluminescence immunoassay analyzer. The reaction cup clearing method comprises the following steps: a first gripper (1) is driven to move linearly along a gripper movement axis (3), and grasp a reaction cup in a reaction cup hole in a first target, so as to complete a cup discarding action; and a second gripper (2) is driven to move linearly along the gripper movement axis (3), and grasp a reaction cup in a reaction cup hole in a second target, so as to complete a cup discarding action. A cup clearing action for reaction cups in reaction cup holes can be realized simply by the linear movement of grippers, and multiple grippers operate independently, effectively solving the problem in the prior art that cup grippers need to move a relatively long distance to realize a cup grasping action and a cup discarding action, and the cup grippers lack collision avoidance control logic and are prone to positional interference, which affects the cup clearing efficiency of analytical instruments.

Description

Methods for cleaning reaction cups, mode selection methods, and chemiluminescence immunoassay analyzers

[0001] Cross-reference to related applications

[0002] This application claims priority to Chinese Patent Application No. 202411996807.5, filed with the Chinese Patent Office on December 31, 2024, entitled "Method for cleaning reaction cups, mode selection method and chemiluminescence immunoassay analyzer", the entire contents of which are incorporated herein by reference. Technical Field

[0003] This application relates to the field of automated in vitro diagnostic equipment, specifically to a method for cleaning reaction cups, a mode selection method, and a chemiluminescence immunoassay analyzer. Background Technology

[0004] Chemiluminescence immunoassay analyzers are highly sensitive, wide-linear-range detection instruments that combine the principles of chemiluminescence and antibody-antigen reactions. They are widely used for the quantitative detection of proteins, hormones, tumor markers, infectious diseases, and other antibodies and antigens in human serum, demonstrating significant clinical importance and application value.

[0005] In fully automated chemiluminescence immunoassay analyzers, the reaction containers for samples and reagents are disposable reaction cups. The testing process—sample addition, reagent addition, incubation, cleaning and separation, and photometric measurement—is completed through the circulation of these reaction cups within the instrument. Therefore, each component of the analyzer has a large number of reaction cup wells. Before the analyzer returns to a usable state after a shutdown, the cup-grabbing mechanism on the instrument needs to automatically clear any reaction cups remaining inside due to malfunctions or manual adjustments. Specifically, the cup-grabbing mechanism checks each well; if a cup is present, it is moved to the discard position and discarded; if no cup is present, the process continues to the next well until the cup-grabbing process is complete.

[0006] However, due to the large number of reaction cup positions inside chemiluminescence analyzers, and the limitation of the cup-cleaning efficiency by the cup-grabbing hand's own movement speed, the entire cup-cleaning process takes a long time. During this period, users can only wait for the process to finish, significantly reducing the efficiency of instrument production, debugging, and laboratory testing. For example, patent application CN207816996U discloses an automatic analysis device. Specifically, it discloses a first cup-grabbing hand and a second cup-grabbing hand. The first cup-grabbing hand is configured to move through the cup-separating position and the first pre-operating position. When the sample-addition position is outside the reaction plate, the first cup-grabbing hand's movement trajectory also passes through the sample-addition position. The second cup-grabbing hand is configured to move through the first post-operating position, the second post-operating position, the mixing mechanism, and the magnetic separation unit. The first cup-grabbing hand is a three-dimensional moving structure or a rotating structure, and the second cup-grabbing hand is also a three-dimensional moving structure or a rotating structure. Therefore, it can be seen that the cup-grabbing hand in the prior art needs to move separately in the horizontal X-axis and Y-axis directions to grasp the reaction cups within the reaction cup positions and transfer them to the discarding position for disposal. In the above process, the cup-grabbing hand needs to move a considerable distance to grasp and toss the cup. Furthermore, the lack of avoidance control logic between the two cup-grabbing hands makes them prone to positional interference, further impacting the cleaning efficiency of the analytical instrument. Therefore, those skilled in the art require a new method for cleaning reaction cups to improve the cleaning efficiency of the cup-grabbing hand. Summary of the Invention

[0007] Therefore, the technical problem to be solved by this application is how to address the low cleaning efficiency of analytical instruments in the prior art. To this end, this application provides a method for cleaning reaction cups, comprising the following steps:

[0008] The first gripper is driven to move in a straight line along the gripper's motion axis to grab the reaction cup in the reaction cup hole of the first target and complete the cup throwing action; at the same time, the second gripper is driven to move in a straight line along the gripper's motion axis to grab the reaction cup in the reaction cup hole of the second target and complete the cup throwing action.

[0009] Optionally, the first target includes: a first portion of the location in the incubation block; the second target includes: a second portion of the location in the incubation block;

[0010] The incubation block is driven to move linearly, positioning the corresponding reaction cup hole on the axis of motion of the gripper, so that the moving gripper can pick up or put down the reaction cup.

[0011] Optionally, the first target further includes: a sample loading plate and / or a dilution block; the second target further includes: a magnetic separation plate and / or a measuring optical plate;

[0012] The sample loading plate and / or the magnetic separation plate and / or the measuring plate are driven to rotate, positioning the corresponding reaction cup orifice on the axis of motion of the gripper, so that the moving gripper can pick up or put down the reaction cup;

[0013] The movable gripper includes at least: the first gripper and the second gripper.

[0014] Optionally, the movable gripper consists of a first gripper and a second gripper;

[0015] The first and second portions of the location do not overlap and contain a similar number of reaction cup pores.

[0016] Optionally, the reaction cup holes of the incubation block are arranged in a 15x16 array in the XY direction;

[0017] The first part of the location includes: rows Y1 to Yn in the incubation block, and columns X1 to Xm in the incubation block excluding rows Y1 to Yn;

[0018] The second part of the location includes: the Xm+1th column to the total Xth column in the incubation block, excluding rows Y1 to Yn.

[0019] Optionally, a first cup-throwing hole located on the movement axis of the gripper is provided between the dilution block and the incubation block; the initial position and cup-throwing position of the first gripper are both located at the first cup-throwing hole; and / or,

[0020] The dilution block is driven to move linearly, positioning the corresponding reaction cup orifice on the axis of motion of the gripper, allowing the moving gripper to pick up or put down the reaction cup; and / or,

[0021] A second cup-throwing hole is provided between the magnetic separation disk and the measuring optical disk, located on the movement axis of the gripper; the initial position and the cup-throwing position of the second gripper are both located at the second cup-throwing hole.

[0022] A method for selecting a cleaning mode for a reaction vessel includes:

[0023] The system acquires and analyzes the operational status records of the equipment and determines the cleaning mode based on these records. The operational status records include normal testing or equipment debugging. The cleaning modes include the following:

[0024] The full clean mode cleans each reaction cup in the well of the magnetic separation plate, measuring plate, incubation block, dilution block, and sample loading plate one by one.

[0025] In the spot check cleaning mode, each reaction cup in the well of the magnetic separation plate, measuring plate, dilution block and sample loading plate is cleaned one by one; in addition, the reaction cup wells in the incubation block are also checked and cleaned.

[0026] The memory clear mode clears the positions of the vias containing reaction cups recorded during the operation. Specifically, the analyzer uses software to create a table of the entire machine's via positions, recording whether reaction cups are present in the vias of the transfer disc, dilution mechanism, incubation block, magnetic separation disc, and measuring disc during operation. For machine reset and cup clearing after a fault shutdown or manual shutdown, the memory clear mode only clears the vias containing reaction cups.

[0027] Optionally, the cleaning mode can be determined based on the operating status record, including the following options:

[0028] If the normal test is performed, the control analysis device enters the memory clearing mode; wherein, the normal test includes: clinical test or system test;

[0029] If the device is being debugged, the control analysis device will enter either full cup cleaning mode or spot check cup cleaning mode.

[0030] Optionally, the operation status record may further include: analyzing whether the equipment has been powered off and restarted;

[0031] If the analytical equipment is restarted after a power outage, the control system will directly enter either the full cup cleaning mode or the spot check cup cleaning mode. Specifically, if the instrument was powered off and restarted or entered the overall debugging or basic performance process before cup cleaning, the target users are usually the instrument manufacturer's production or after-sales personnel; in the above situations, the full cleaning mode or the spot check cleaning mode will be used.

[0032] If the analytical device is not restarted after a power outage, the control system continues to acquire the operational status records of the analytical device and determines the cleaning mode based on these records. Specifically, if the device malfunctions or is manually shut down during clinical testing or system inspection but is not restarted, and the target user is a hospital or laboratory operator who will not manually add reaction cups to the instrument's reaction cup wells, and the status of each well recorded by the software is reliable, the memory cleaning mode is used in the above situation.

[0033] Optionally, the full wipe mode includes the following steps:

[0034] Step S101: The first gripper removes the reaction cups in each reaction cup well in the sample loading tray and the dilution block, as well as the reaction cups in each reaction cup well in rows Y1 to Yn of the incubation block one by one.

[0035] At the same time, the second gripper removes the reaction cups one by one from each reaction cup hole in the measuring optical disc and the magnetic separation disc;

[0036] In step S102, the first gripper clears columns X1 to Xm one by one in the incubation block, excluding rows Y1 to Yn; at the same time, the second gripper clears columns Xm+1 to X total columns one by one in the incubation block, excluding rows Y1 to Yn.

[0037] The first gripper and the second gripper perform the cup-cleaning actions for each corresponding row of reaction cup holes in the incubation block synchronously; and / or, during the cup-cleaning process of each row of the incubation block, the first gripper and the second gripper wait for each other to finish cleaning the current reaction cup hole before simultaneously entering the next reaction cup hole for cup-cleaning; and / or, when the first gripper and the second gripper clear adjacent reaction cup holes, one of them moves to the cup-throwing position to avoid them; and / or, during the process of the first gripper and the second gripper cleaning the incubation block row by row, the first gripper and the second gripper complete the cup-cleaning action of that row before simultaneously entering the next row for cup-cleaning.

[0038] Optionally, the random inspection mode includes the following steps:

[0039] The first gripper removes the reaction cups one by one from each reaction cup well in the sample loading plate and the dilution block; the second gripper removes the reaction cups one by one from each reaction cup well in the measuring disc and the magnetic separation disc.

[0040] The first gripper and the second gripper use a combination of row-by-row cup cleaning and spot-checking cup cleaning on the incubation block. The scheme is as follows: row Y1 of the incubation block is cleaned row by row; if no reaction cups are found when the gripper cleans the previous row of the incubation block, the X1, Xa, and Xb holes of the current row of the incubation block are spot-checked; if a reaction cup is found in the previous row of the incubation block, the next row is completely cleaned.

[0041] A chemiluminescence immunoassay analyzer, employing the above-mentioned method for cleaning reaction cups, includes:

[0042] A first gripper and a second gripper, the first gripper and the second gripper being driven to move in a straight line along the gripper motion axis; and a magnetic separation disk, a measuring disk, an incubation block, a dilution block and a sample loading disk.

[0043] The technical solution of this application has the following advantages:

[0044] 1. The method for cleaning reaction cups provided in this application includes the following steps: a first gripper is driven to move in a straight line along the gripper's motion axis to grab the reaction cup in the reaction cup hole of a first target and complete the cup-throwing action; at the same time, a second gripper is driven to move in a straight line along the gripper's motion axis to grab the reaction cup in the reaction cup hole of a second target and complete the cup-throwing action.

[0045] Compared to existing technologies where the gripper needs to move along the X and Y axes in a horizontal direction, in this application, the first and second grippers are driven to move in a straight line along the gripper's motion axis, thus enabling the gripping of the reaction cup in the reaction cup orifice. This gripping method effectively improves the efficiency of gripping and transferring the reaction cup. Furthermore, in this application, the first gripper is positioned to grip the reaction cup of the first target, and the second gripper is positioned to grip the reaction cup of the second target. This ensures that the first and second grippers operate independently without interfering with each other, thereby avoiding positional interference between the grippers and guaranteeing efficient cleaning of the analytical instrument.

[0046] 2. The method for cleaning reaction cups provided in this application, wherein the sample loading plate and / or the magnetic separation plate and / or the measuring optical plate are driven to rotate, positioning the corresponding reaction cup hole on the movement axis of the gripper, so that the moving gripper can pick up or put down the reaction cup;

[0047] The incubation block and / or the dilution block are driven to move linearly, positioning the corresponding reaction cup hole on the axis of motion of the gripper, so that the moving gripper can pick up or put down the reaction cup;

[0048] In this application, by rotating the sample loading plate, magnetic separation plate, and measuring plate, the reaction cup holes on these plates are sequentially moved to positions traversed by the gripper's motion axis. This allows the gripper to clean the reaction cups in different positions during linear motion, effectively shortening the gripper's travel distance and improving cleaning efficiency. Furthermore, the incubation block and dilution block can also be driven to move linearly, moving the reaction cup holes on them to positions traversed by the gripper's motion axis. This allows the gripper to clean the reaction cups on the incubation block and dilution block through linear motion, further shortening the gripper's travel distance and improving cleaning efficiency.

[0049] 3. The method for cleaning reaction cups provided in this application, wherein the movable gripper is composed of a first gripper and a second gripper; the first part position and the second part position do not overlap with each other and contain a similar number of reaction cup holes.

[0050] In this application, the first gripper and the second gripper respectively grip the reaction cup at the first part position and the second part position. The first part position and the second part position do not overlap and contain a similar number of reaction cup holes, which can make the workload of the first gripper and the second gripper similar and prevent them from interfering with each other, thereby improving the efficiency of cleaning the reaction cup in this application.

[0051] 4. The method for cleaning reaction cups provided in this application includes a first cup-throwing hole located on the movement axis of the gripper between the dilution block and the incubation block; the initial position of the first gripper and the cup-throwing position are both located in the first cup-throwing hole; and a second cup-throwing hole located on the movement axis of the gripper is provided between the magnetic separation disk and the measuring disk; the initial position of the second gripper and the cup-throwing position are both located in the second cup-throwing hole.

[0052] In this application, by setting the initial positions of the first and second grippers and the cup-throwing position at the location of the cup-throwing hole, the length of the movement path required by the grippers can be effectively reduced, thereby improving the cup-throwing efficiency.

[0053] 5. The methods for cleaning reaction cups provided in this application include: full cleaning mode, spot cleaning mode, and memory cleaning mode.

[0054] In this application, during clinical testing or system inspection processes, if the instrument shuts down due to a malfunction or is manually shut down by the user without powering off and restarting, the target user is a hospital or laboratory operator. In this situation, there is no possibility of manually adding reaction cups to the instrument's reaction cup positions, and the status of each position recorded by the software is reliable. Therefore, the above-mentioned memory cleaning mode can be used for the entire instrument cleaning process in this scenario. The memory cleaning mode only cleans the positions where there are cups, avoiding the useless work of the cup-handling hand having to grasp and explore every position, realizing the rapid completion of the cleaning process, which can effectively save cleaning time and reduce user waiting time.

[0055] Additionally, if the instrument was powered off and restarted or entered the overall debugging or basic performance process before cleaning the cups, the users are typically the instrument manufacturer's production or after-sales personnel. Due to debugging or testing needs, the operators may have manually placed reaction cups into the machine's ports. In these situations, the port status recorded by the software is unreliable and cannot be memorized for cleaning; therefore, a full cleaning mode or a spot-check cleaning mode is required. In this case, users can also select the cleaning mode in the software interface as needed. Furthermore, if the actions of the manufacturer's production or after-sales personnel are largely controllable, and the reaction cup ports used for overall debugging and basic performance are relatively fixed, operators can choose the spot-check cleaning mode for quick cup cleaning.

[0056] 6. The method for cleaning reaction cups provided in this application involves the first and second grippers waiting for each other to finish cleaning the current reaction cup hole before simultaneously moving to the next reaction cup hole for cleaning. In this application, by configuring the first and second grippers to wait for each other to finish cleaning the current reaction cup hole before simultaneously moving to the next reaction cup hole, the synchronous operation of the first and second grippers can be effectively guaranteed, avoiding positional interference between the grippers.

[0057] 7. In the method for cleaning reaction cups provided in this application, when the first gripper and the second gripper are emptying adjacent reaction cup holes, one of them moves to a cup-discarding position to avoid them. For example, when the first gripper is emptying column X8 of the incubation block excluding rows Y1 to Y3, the second gripper moves to the first cup-discarding hole to avoid them. This arrangement ensures that when multiple grippers work together, they avoid each other during the process of gripping reaction cups in adjacent reaction cup holes, thus preventing positional interference and malfunctions.

[0058] 8. In the method for cleaning reaction cups provided in this application, during the process of cleaning the incubation block row by row by the first gripper and the second gripper, after both the first gripper and the second gripper have completed the cleaning action for that row, they simultaneously move on to the next row to perform the cleaning action. This setup effectively enables multiple grippers to simultaneously perform cup-discarding work on each row, ensuring work efficiency and avoiding positional interference.

[0059] 9. The method for cleaning reaction cups provided in this application, wherein the sampling and cleaning mode includes the following steps:

[0060] The first gripper removes the reaction cups one by one from each reaction cup well in the sample loading plate and the dilution block; the second gripper removes the reaction cups one by one from each reaction cup well in the measuring disc and the magnetic separation disc.

[0061] The first gripper and the second gripper use a combination of row-by-row cup cleaning and spot-checking cup cleaning on the incubation block. The scheme is as follows: row Y1 of the incubation block is cleaned row by row; if no reaction cups are found when the gripper cleans the previous row of the incubation block, the X1, Xa, and Xb holes of the current row of the incubation block are spot-checked; if a reaction cup is found in the previous row of the incubation block, the next row is completely cleaned.

[0062] In this application, the handle performs row-by-row cleaning of the reaction cups in the first row of the incubation block; based on the cleaning results, it is determined whether to perform a full cleaning of the next row. This sampling cleaning method effectively removes the reaction cups from the incubation block while ensuring cleaning efficiency.

[0063] 10. The chemiluminescence immunoassay analyzer provided in this application uses the reaction cup cleaning method described above in this application. Therefore, it possesses all the advantages of the reaction cup cleaning method described in this application. Attached Figure Description

[0064] To more clearly illustrate the technical solutions in the specific embodiments of this application or the prior art, the drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of this application. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0065] Figure 1 is a schematic diagram of the working state of the chemiluminescence immunoassay analyzer provided in this application, showing the gripper grasping the reaction cup in the incubation block.

[0066] Figure 2 is a schematic diagram of the judgment logic of the chemiluminescence immunoassay analyzer provided in this application, which allows for the selection of different cup cleaning modes as needed.

[0067] Explanation of reference numerals in the attached diagram: 1-First gripper; 2-Second gripper; 3-Gripper movement axis; 4-Sample loading plate; 5-Dilution block; 6-Incubation block; 7-Magnetic separation plate; 8-Measuring plate; 9-First part position; 10-Second part position; 11-First cup throwing hole; 12-Second cup throwing hole. Detailed Implementation

[0068] The technical solutions of this application will now be clearly and completely described with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of this application. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0069] In the description of this application, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this application. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0070] Example 1

[0071] Referring to Figure 1, Figure 1 shows a schematic diagram of the working state of the chemiluminescence immunoassay analyzer in the embodiment of this application, where the gripper grasps the reaction cup in the incubation block.

[0072] The method for cleaning the reaction cup provided in this embodiment includes the following steps:

[0073] The first gripper 1 is driven to move in a straight line along the gripper motion axis 3 to grasp the reaction cup in the reaction cup hole of the first target and complete the cup throwing action; the first target includes: sample loading plate 4, dilution block 5, and a first part position 9 in incubation block 6; the reaction cup hole positions of the incubation block 6 are arranged in an array of 15 by 16 in the XY direction as shown in Figure 1; the first part position 9 includes: rows Y1 to Y3 in the incubation block 6, and columns X1 to X8 in the incubation block 6 excluding rows Y1 to Y3;

[0074] Simultaneously, the second gripper 2 is driven to move in a straight line along the gripper motion axis 3, grasping the reaction cup in the reaction cup hole of the second target and completing the cup throwing action. The aforementioned second target includes: magnetic separation disk 7, measuring disk 8, and the second part position 10 in the incubation block 6; the reaction cup hole positions of the incubation block 6 are arranged in an XY direction of 15 x 16 array as shown in Figure 1; the second part position 10 includes: columns X9 to X15 of the incubation block 6, excluding rows Y1 to Y3.

[0075] In this embodiment, the reaction cups in the reaction cup holes on the sample loading plate 4, magnetic separation plate 7, measuring plate 8, incubation block 6, and dilution block 5 are cleared by the linear movement of the first gripper 1 and the second gripper 2. As shown in Figure 1, the sample loading plate 4, the magnetic separation plate 7, and the measuring plate 8 are driven to rotate, positioning the corresponding reaction cup holes on the gripper's movement axis 3 for the moving gripper to pick up or put down the reaction cups; the incubation block 6 and the dilution block 5 are driven to move linearly, positioning the corresponding reaction cup holes on the gripper's movement axis 3 for the moving gripper to pick up or put down the reaction cups.

[0076] A first cup-throwing hole 11 is provided between the dilution block 5 and the incubation block 6, located on the gripper's movement axis 3; the initial position and cup-throwing position of the first gripper 1 are both located within this first cup-throwing hole 11. A second cup-throwing hole 12 is provided between the magnetic separation disk 7 and the measuring disk 8, located on the gripper's movement axis 3; the initial position and cup-throwing position of the second gripper 2 are both located within this second cup-throwing hole 12. By setting the initial positions and cup-throwing positions of the first gripper 1 and the second gripper 2 at the locations of the cup-throwing holes, the length of the gripper's required movement path can be effectively reduced, thereby improving cup-throwing efficiency.

[0077] Furthermore, to ensure that the workload of the first gripper 1 and the second gripper 2 is similar and that they do not interfere with each other, thereby improving the efficiency of cleaning the reaction cups in this application, the first part position 9 and the second part position 10 do not overlap and contain a similar number of reaction cup holes. Simultaneously, based on the above-mentioned cleaning area division, the two grippers are each responsible for cleaning approximately the same number of reaction cup holes, avoiding a situation where one gripper is cleaning while the other has finished cleaning and is idle for a long time, thus improving the overall cleaning speed.

[0078] In this embodiment, referring to Figure 2, Figure 2 shows a schematic diagram of the judgment logic of the chemiluminescence immunoassay analyzer in this embodiment of the application, which selects different cleaning modes as needed.

[0079] Methods for cleaning reaction cups include:

[0080] Full clean mode, cleans each reaction cup in each reaction cup well in magnetic separation plate 7, measuring plate 8, incubation block 6, dilution block 5 and sample loading plate 4 one by one;

[0081] In the spot check cleaning mode, the reaction cups in each reaction cup well in the magnetic separation disk 7, measuring disk 8, dilution block 5 and sample loading disk 4 are cleaned one by one; and the reaction cup wells in the incubation block 6 are also checked and cleaned.

[0082] In the memory clear mode, the analyzer establishes a status table of the entire machine's boreholes through software. During operation, it records whether there are reaction cups in the boreholes of the transfer disc, dilution mechanism, incubation block 6, magnetic separation disc 7, and measuring disc 8. The memory clear mode only clears the boreholes containing reaction cups after a fault shutdown or manual shutdown.

[0083] If the instrument was powered off and restarted or entered the overall debugging or basic performance process before cleaning the cups, the users are usually the instrument manufacturer's production or after-sales personnel. Due to debugging or testing needs, the operator may have manually placed reaction cups into the machine's ports. In these situations, the port status recorded by the software is unreliable and cannot be cleared from memory. Therefore, a full cleaning mode or a spot-check cleaning mode is required. In this case, the user can also select the cleaning mode in the software interface as needed.

[0084] The full wipe mode includes the following steps:

[0085] Step S101: The first gripper 1 removes the reaction cups in each reaction cup well in the sample loading tray 4 and the dilution block 5, as well as the reaction cups in each reaction cup well in rows Y1 to Y3 of the incubation block 6 one by one.

[0086] At the same time, the second gripper 2 removes the reaction cups in each reaction cup hole of the measuring optical disc 8 and the magnetic separation disc 7 one by one;

[0087] In step S102, the first gripper 1 clears columns X1 to X8 of the incubation block 6 one by one, excluding rows Y1 to Y3; at the same time, the second gripper 2 clears columns X9 to X15 of the incubation block 6 one by one, excluding rows Y1 to Y3.

[0088] In addition, the random inspection mode includes the following steps:

[0089] The first gripper 1 removes the reaction cups one by one from each reaction cup position in the sample loading plate 4 and the dilution block 5; the second gripper 2 removes the reaction cups one by one from each reaction cup position in the measuring disc 8 and the magnetic separation disc 7.

[0090] The first gripper 1 and the second gripper 2 use a combination of row-by-row cup cleaning and spot-checking cup cleaning on the incubation block 6. The scheme is as follows: row-by-row cup cleaning is performed on the Y1 row of the incubation block 6; if no reaction cups are found when the gripper cleans the previous row of the incubation block 6, then spot-checking is performed on the X1, Xa, and Xb holes of the current row of the incubation block 6; if a reaction cup is found in the previous row of the incubation block 6, then the next row is completely cleaned.

[0091] During the cup cleaning process, the first gripper 1 and the second gripper 2 are effectively synchronized to avoid positional interference between the grippers and improve cleaning efficiency. The following operational logic rules govern the cup cleaning process:

[0092] 1. The first gripper 1 and the second gripper 2 perform the cup cleaning action synchronously for each corresponding row of reaction cup holes in the incubation block 6.

[0093] 2. During the cleaning process of each row of the incubation block 6, the first gripper 1 and the second gripper 2 wait for each other to finish cleaning the current reaction cup hole before simultaneously moving to the next reaction cup hole for cleaning.

[0094] 3. When the first gripper 1 and the second gripper 2 clear the adjacent reaction cup holes, one of them moves to the cup-throwing position to avoid them; for example, when the first gripper 1 clears the X8 column in the incubation block 6 except for rows Y1 to Y3, the second gripper 2 moves to the first cup-throwing hole 11 to avoid them.

[0095] 4. During the process of cleaning the cups of the incubation block 6 row by row by the first gripper 1 and the second gripper 2, after the first gripper 1 and the second gripper 2 have completed the cleaning action of the row, they will simultaneously move to the next row to perform the cleaning action.

[0096] The first target includes: a first portion of position 9 in the incubation block 6; and the first target further includes: a sample loading plate 4 and / or a dilution block 5;

[0097] The second objective includes: a second portion of position 10 in the incubation block 6; and the second objective further includes: a magnetic separation disk 7 and / or a measuring disk 8;

[0098] Of course, this embodiment does not specifically limit the objects included in the first and second objectives. In other embodiments, the first objective includes: the first portion of position 9 in the incubation block 6, and one of the sample loading plate 4 and the dilution block 5; the second objective includes: the second portion of position 10 in the incubation block 6, and one of the magnetic separation plate 7 and the measuring plate 8. Moreover, in this embodiment, the first and second objectives may not include the incubation block 6, and other objectives in the first and second objectives can be selected all, one, or none as needed.

[0099] Of course, this embodiment does not specifically limit the array arrangement of the incubation blocks 6, nor the specific positions of the first and second targets. In other embodiments, the incubation blocks 6 can be arranged in an 18x18 array along the XY direction, or in other array arrangements. Furthermore, the system can change the specific positions of the first and second targets corresponding to the first gripper 1 and the second gripper 2, respectively, according to the operator's needs.

[0100] Of course, this embodiment does not specifically limit the number of grippers used to transfer reaction cups in the chemiluminescence immunoassay analyzer. In other embodiments, the chemiluminescence immunoassay analyzer is provided with three or more grippers.

[0101] Of course, this embodiment does not specifically limit the position of the adjacent reaction cup holes of the first gripper 1 and the second gripper 2. In other embodiments, when the first gripper 1 and the second gripper 2 clear the adjacent reaction cup holes, one of them moves to the cup-throwing position to avoid them. The specific position where the first gripper 1 and the second gripper 2 avoid each other can be determined according to the operator's settings.

[0102] Of course, this embodiment does not specifically limit the positions included in the first part position 9 and the positions included in the second part position 10. In other embodiments, the positions of the incubation block 6 included in the first part position 9 can be selected as any row and any column as needed. The positions of the incubation block 6 included in the second part position 10 can also be selected as any row and any column as needed.

[0103] Example 2

[0104] A chemiluminescence immunoassay analyzer employs the reaction cup cleaning method disclosed in Example 1 above, comprising: a first gripper 1 and a second gripper 2, the first gripper 1 and the second gripper 2 being driven to move in a straight line along the gripper motion axis 3; and a magnetic separation disk 7, a measuring disk 8, an incubation block 6, a dilution block 5 and a sample loading disk 4.

[0105] Obviously, the above embodiments are merely illustrative examples for clear explanation and are not intended to limit the implementation. Those skilled in the art will recognize that other variations or modifications can be made based on the above description. It is neither necessary nor possible to exhaustively list all possible implementations here. However, obvious variations or modifications derived therefrom are still within the scope of protection of this application.

Claims

1. A method for cleaning a reaction vessel, characterized in that, Includes the following steps: The cup is cleaned by a moving gripper, which includes at least: a first gripper (1) and a second gripper (2); The first gripper (1) is driven to move in a straight line along the gripper motion axis (3) to grab the reaction cup in the reaction cup hole of the first target and complete the cup throwing action; at the same time, the second gripper (2) is driven to move in a straight line along the gripper motion axis (3) to grab the reaction cup in the reaction cup hole of the second target and complete the cup throwing action.

2. The method for cleaning the reaction vessel according to claim 1, characterized in that, The first target includes: a first portion of the incubation block (6) at position (9); the second target includes: a second portion of the incubation block (6) at position (10); The incubation block (6) is driven to move linearly, positioning the corresponding reaction cup hole on the gripper's motion axis (3) so that the moving gripper can pick up or put down the reaction cup.

3. The method for cleaning the reaction vessel according to claim 2, characterized in that, The first target further includes: a sample loading plate (4) and / or a dilution block (5); the second target further includes: a magnetic separation plate (7) and / or a measuring plate (8); the sample loading plate (4) and / or the magnetic separation plate (7) and / or the measuring plate (8) are driven to rotate, positioning the corresponding reaction cup orifice on the gripper's motion axis (3) for the moving gripper to pick up or put down the reaction cup.

4. The method for cleaning the reaction vessel according to claim 2, characterized in that, The movable gripper is composed of the first gripper (1) and the second gripper (2); the first part position (9) and the second part position (10) do not overlap with each other and contain similar numbers of reaction cup holes; And / or, The first part of the position (9) includes: rows Y1 to Yn in the incubation block (6), and columns X1 to Xm in the incubation block (6) excluding rows Y1 to Yn; wherein, the first part of the position (9) is close to the measuring optical disc (8); The second part of the position (10) includes: the Xm+1th column to the total Xth column in the incubation block (6), excluding the Y1th to Ynth rows; wherein the second part of the position (10) is close to the dilution block (5).

5. The method for cleaning the reaction vessel according to claim 3, characterized in that, A first cup-throwing hole (11) is provided between the dilution block (5) and the incubation block (6) on the movement axis (3) of the gripper; the initial position and cup-throwing position of the first gripper (1) are both located at the first cup-throwing hole (11); and / or, A second cup-throwing hole (12) is provided between the magnetic separation disk (7) and the measuring disk (8) on the gripper movement axis (3); the initial position and cup-throwing position of the second gripper (2) are both located in the second cup-throwing hole (12).

6. A method for selecting a cleaning mode for a reaction vessel, characterized in that, include: The system acquires and analyzes the operational status records of the equipment and determines the cleaning mode based on these records. The operational status records include normal testing or equipment debugging. The cleaning modes include the following: Full clean mode, clean the reaction cups in the reaction cup positions of the magnetic separation disk (7) and / or measuring disk (8) and / or incubation block (6) and / or dilution block (5) and / or sample loading disk (4) one by one; In the spot check cleaning mode, the reaction cups in the reaction cup positions of the magnetic separation disk (7) and / or measuring disk (8) and / or dilution block (5) and / or sample loading disk (4) are cleaned one by one; and / or, the reaction cup positions in the incubation block (6) are checked and cleaned. The memory clearing mode clears the cup hole positions recorded during the work process.

7. The method for selecting a cleaning mode for a reaction vessel according to claim 6, characterized in that, The cleaning mode is determined based on the operating status record. Includes the following options: If the normal test is performed, the control analysis device enters the memory clearing mode; wherein, the normal test includes: clinical test or system test; If the device is being debugged, the control analysis device will enter either full cup cleaning mode or spot check cup cleaning mode.

8. The method for selecting a cleaning mode for a reaction vessel according to claim 6 or 7, characterized in that, The operational status record also includes: analyzing whether the equipment has been restarted after a power outage; If the analysis equipment is restarted after a power outage, control the analysis equipment to directly enter the full cup cleaning mode or the spot check cup cleaning mode; If the analysis device is not powered off and restarted, the control analysis device continues to acquire the operation status record of the analysis device, and determines the cup cleaning mode based on the status record.

9. The method for selecting a cleaning mode for a reaction vessel according to claim 6, characterized in that, The full wipe mode includes the following steps: Step S101: The first gripper (1) removes the reaction cups in each reaction cup well in the sample loading plate (4) and the dilution block (5), as well as the reaction cups in each reaction cup well in rows Y1 to Yn in the incubation block (6) one by one. At the same time, the second gripper (2) cleans the reaction cups in each reaction cup hole of the measuring optical disc (8) and the magnetic separation disc (7) one by one; In step S102, the first gripper (1) clears columns X1 to Xm in the incubation block (6) one by one, excluding rows Y1 to Yn; at the same time, the second gripper (2) clears columns Xm+1 to X total columns in the incubation block (6) one by one, excluding rows Y1 to Yn. The first gripper (1) and the second gripper (2) perform the cup-cleaning action of each corresponding row of reaction cup holes in the incubation block (6) simultaneously; and / or, during the cup-cleaning process of each row of the incubation block (6), the first gripper (1) and the second gripper (2) wait for each other to finish cleaning the current reaction cup hole before simultaneously entering the next reaction cup hole for cup-cleaning; and / or, when the first gripper (1) and the second gripper (2) clear adjacent reaction cup holes, one of them moves to the cup-throwing position to avoid them; and / or, during the process of the first gripper (1) and the second gripper (2) cleaning the incubation block (6) row by row, after the first gripper (1) and the second gripper (2) have both completed the cup-cleaning action of that row, they simultaneously enter the next row for cup-cleaning.

10. The method for selecting a cleaning mode for a reaction vessel according to claim 6, characterized in that, The random inspection mode includes the following steps: The first gripper (1) removes the reaction cups one by one from each reaction cup position in the sample loading plate (4) and the dilution block (5); the second gripper (2) removes the reaction cups one by one from each reaction cup position in the measuring disc (8) and the magnetic separation disc (7); The first gripper (1) and the second gripper (2) use a combination of row-by-row cup cleaning and spot-checking cup cleaning on the incubation block (6). The scheme is as follows: row-by-row cup cleaning is performed on the Y1 row of the incubation block (6); if no reaction cups are found when the gripper cleans the previous row of the incubation block (6), the X1, Xa, and Xb holes of the current row of the incubation block (6) are spot-checked and cleaned; if a reaction cup is found in the previous row of the incubation block (6), the next row is completely cleaned.

11. The method for selecting a cleaning mode for a reaction vessel according to claim 6, characterized in that, A method for cleaning reaction cups using any one of claims 1 to 5.

12. A chemiluminescence immunoassay analyzer, comprising the method for cleaning reaction cups as described in any one of claims 1 to 5, characterized in that, include: A first gripper (1) and a second gripper (2), the first gripper (1) and the second gripper (2) being driven to move in a straight line along the gripper motion axis (3); and a magnetic separation disk (7), a measuring disk (8), an incubation block (6), a dilution block (5) and a sample loading disk (4).

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