Improvements in or relating to 2-nitro-4-methylsulfonylbenzoic acid
The oxidation process improves the synthesis of NMSBA by reusing reaction by-products and controlling temperature, addressing inefficiencies in existing methods and enhancing yield and purity.
WO2026146219A1PCT designated stage Publication Date: 2026-07-09SYNGENTA CROP PROTECITON AG
Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- SYNGENTA CROP PROTECITON AG
- Filing Date
- 2026-01-05
- Publication Date
- 2026-07-09
AI Technical Summary
Technical Problem
Existing synthesis routes for 4-(methylsulfonyl)-2-nitrobenzoic acid (NMSBA) from 1-methyl-4-(methylsulfonyl)-2-nitrobenzene (NMST) are inefficient and require unnecessary reagents and solvents, necessitating an improved oxidation process.
Method used
An oxidation process using an aqueous suspension of NMST, sulfuric acid, and a catalyst, with the reuse of mother and washing liquors from previous oxidations, and controlled temperature variations to achieve high yield and purity of NMSBA.
Benefits of technology
The process achieves good yield and excellent purity of NMSBA while reducing waste by reusing reaction by-products, and also optimizes the synthesis of intermediates like mesotrione.
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Smart Images
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Abstract
The following invention relates to an improved oxidation process whereby 1-methyl-4-(methylsulfonyl)-2-nitrobenzene (NMST) is oxidized to 4-(methylsulfonyl)-2-nitrobenzoic acid (NMSBA).
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