Human tissue scaffold assembled from medical modules

Abstract

A human tissue scaffold assembled from medical modules. The human tissue scaffold is formed by assembling a plurality of medical modules, and a titanium clip is embedded within each medical module. Medical module finished products undergo quality inspection and can better meet sterile requirements, and are assembled intraoperatively and then rapidly implanted into the body; flexible, rapid and accurate repair can be achieved during surgery according to actual requirements; and modules are manually assembled, and the operation is simple. The position and number of titanium clips can be flexibly adjusted according to the specific morphology of tissues and the size of a residual cavity during surgery, thereby ensuring precise positioning for postoperative radiotherapy.

Description

A modular medical scaffold for human tissue Technical fields:

[0001] This invention relates to the field of medical materials, and more particularly to the field of human tissue scaffolds. Background technology:

[0002] Human tissue repair and reconstruction surgery is a common surgical procedure aimed at repairing tissue defects caused by radical surgery or trauma. A search revealed that patent number "CN109172044B" discloses a biodegradable gradient-pore breast scaffold. While 3D printing can meet the need for precise morphology, it requires specialized printing equipment, has specific cleanliness requirements for the printing environment, and takes a considerable amount of time to complete. When the amount of tissue removed during surgery changes, it is necessary to reprint or replace the scaffold with one of different specifications, leading to prolonged surgery time, increased risk of anesthetic complications, and a heavier financial burden. Therefore, how to quickly, accurately, safely, and cost-effectively fill tissue defects and restore the original morphology of the tissue is currently an important issue in human tissue repair and reconstruction surgery. Summary of the Invention

[0003] To address the aforementioned technical challenges, the medical modular scaffold filling technology of this invention employs a modular design of medical materials. These modular materials can be flexibly assembled according to the amount and shape of the lesion tissue removed during tissue reconstruction surgery, creating a filling structure that highly conforms to the morphology of the tissue defect. Compared to traditional fixed-shape scaffolds, this design allows for intraoperative combination and real-time adjustment of the filling materials based on actual needs, ensuring precise repair of tissue defects and significantly improving the personalization and accuracy of the repair effect. Compared to 3D printing, the finished medical modules undergo quality inspection to better ensure sterility, and on-site manual assembly and rapid implantation significantly shorten surgical time.

[0004] Technical solution of the present invention

[0005] A modular medical tissue scaffold, composed of scaffold components, can flexibly and precisely fill tissue areas according to the actual shape of the removed tissue, thereby optimizing postoperative recovery.

[0006] The scaffold assembly of the human tissue scaffold is composed of connector modules and columnar modules.

[0007] The human tissue scaffold assembly is composed of rectangular modules, T-shaped modules, L-shaped modules, and cross-shaped modules spliced ​​together.

[0008] The surface of the connector module of the human tissue scaffold is provided with a socket, which can be used to combine multiple cylindrical modules with the socket in a plug-in manner.

[0009] The insertion holes of the medical modular human tissue scaffold can be precisely adapted to one end of the cylindrical module, and the connector module and the cylindrical module can be spliced ​​together during the operation according to the actual required quantity and volume and shape of the tissue to be removed.

[0010] The rectangular, T-shaped, L-shaped, and cross-shaped modules of the medical modular human tissue scaffold are provided with several protrusions on one side and several recesses on the other side perpendicular to and symmetrical to the protrusions. The protrusions and recesses can be combined by interlocking with each other.

[0011] The rectangular, T-shaped, L-shaped, and cross-shaped modules of the medical modular human tissue scaffold described above have mutually compatible lengths, widths, and heights, and can be spliced ​​together during surgery according to the actual required quantity and volume and shape of the tissue to be removed.

[0012] The medical modules of the human tissue scaffold assembled from medical modules are made of medical-grade metal or medical-grade silicone material.

[0013] The medical module-assembled human tissue scaffold is a biodegradable polymeric biomaterial.

[0014] The polymer biomaterial of the human tissue scaffold assembled by the medical modules is one or more of polylactic acid, polycaprolactone, chitin, polyacetic acid-glycolic acid, polyvinyl alcohol, polyurethane, chitosan, and epoxidized acrylate copolymer.

[0015] The connecting module of the medical modular splicing human tissue scaffold and the cross-shaped module have titanium clips embedded inside. The position and number of titanium clips can be flexibly adjusted according to the specific shape of the tissue and the size of the residual cavity during the operation to ensure accurate positioning for postoperative radiotherapy.

[0016] The method for assembling the medical modular human tissue scaffold is characterized by comprising the following steps:

[0017] S1. Perform the resection surgery according to the scope of the preoperative clinical examination and imaging assessment;

[0018] S2. Measure the length (x), width (y), and height (z) of the excised specimen or surgical cavity;

[0019] S3. Assemble different medical modules into the required stent assembly according to the patient's actual needs;

[0020] S4. Repeat step 3 to create multiple scaffold assemblies and assemble the multiple scaffold assemblies into a tissue plane layer;

[0021] S5. Repeat steps 3 and 4 to splice multiple tissue plane layers, with the length (x) and width (y) of each tissue plane layer being the same as the length (x) and width (y) of the excised specimen;

[0022] S6. Connect different tissue plane layers using modules, and repeat this operation until the height of z is reached, gradually splicing them into a human tissue scaffold module.

[0023] Beneficial effects of the invention

[0024] 1. This invention flexibly assembles medical modular materials into medical tissue scaffolds of different shapes, enabling precise adaptation to individual differences in patient tissues and intraoperative changes during surgery.

[0025] 2. In this invention, titanium clips are embedded in a module of a human tissue scaffold assembled from medical modules. The position and number of titanium clips can be flexibly adjusted according to the specific shape of the tissue and the size of the residual cavity during the operation, so as to ensure accurate positioning for postoperative radiotherapy.

[0026] 3. This invention has strong adaptability to manufacturing processes and the potential for standardized production. Unlike traditional single-molded medical tissue scaffolds, this technology can be quickly assembled according to actual surgical needs, and is easy to operate. It does not require special printing equipment, and the conventional operating room environment can meet the operational requirements, making it highly valuable for clinical application.

[0027] Instruction manual illustrations

[0028] Figures 1, 2, and 3 are plan views of a modular human tissue scaffold.

[0029] Figures 4, 5, and 6 show the component diagrams of a modular human tissue scaffold for medical use.

[0030] Figure 7 is a schematic diagram of the connector module.

[0031] Figure 8 is a schematic diagram of the column module.

[0032] Figures 9 and 10 are schematic diagrams of the rectangular module.

[0033] Figures 11 and 12 are schematic diagrams of the T-shaped module.

[0034] Figures 13 and 14 are schematic diagrams of the L-shaped module.

[0035] Figures 15 and 16 are schematic diagrams of the cross-shaped module.

[0036] Figure 17 is a cross-sectional view of the cross-shaped module.

[0037] Figure 18 is a cross-sectional view of the connector module. Detailed Implementation

[0038] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0039] Example 1

[0040] Please refer to Figure 1-2. Perform the resection surgery according to the scope of the preoperative clinical examination and imaging assessment. Then measure the resected specimen to obtain the specimen's length (x), width (y), and height (z). Based on the measurement results, select the polymer connector module and the cylindrical medical module for splicing.

[0041] Please refer to Figures 7-8. The diameter of the connector module of the human tissue scaffold is 1cm, and the length of the cylindrical medical module is 1.6cm. The medical modules can be spliced ​​into the required shape according to the actual surgical situation.

[0042] Please refer to Figures 4, 5, and 18. The connector module is provided with a socket with a depth of 0.3 cm, which allows the connector module to be spliced ​​with the cylindrical medical module. The two ends of the cylindrical medical module are inserted into the sockets of the connector module to form a tissue assembly.

[0043] Please refer to Figures 1, 4, and 5. During the operation, the components are repeatedly assembled according to the patient's actual condition, and two adjacent medical modules are connected with cylindrical medical modules to gradually assemble them into a tissue plane layer.

[0044] Please refer to Figure 2. During the operation, tissue components are repeatedly assembled according to the patient's actual condition. Multiple tissue plane layers are repeatedly assembled by connecting two adjacent medical modules with cylindrical medical modules. The length (x) and width (y) parameters of each tissue plane layer are the same as the length (x) and width (y) parameters of the corresponding layer of the specimen removed during the operation. Then, two adjacent tissue plane layers are connected with cylindrical medical modules. This operation is repeated until the height (z). The assembled human tissue scaffold structure is implanted into the surgical cavity after resection, drainage is placed, and the wound is closed layer by layer.

[0045] The medical module material can be medical metal or medical silicone, or it can be a biodegradable biomaterial, including one or more of polylactic acid, polycaprolactone, chitosan, polyacetic acid-glycolic acid, polyvinyl alcohol, polyurethane, chitosan, and epoxidized acrylate copolymers. It has excellent biodegradability and can be gradually absorbed by the body after surgery, avoiding long-term foreign body reactions and promoting the patient's postoperative recovery.

[0046] Example 2

[0047] Please refer to Figure 3. Perform the resection surgery according to the scope of the preoperative clinical examination and imaging assessment. Then, measure the resected specimen to obtain the specimen's length (x), width (y), and height (z). Based on the measurement results, select rectangular medical modules, T-shaped modules, L-shaped modules, and cross-shaped modules to splice the human tissue scaffold.

[0048] Please refer to Figures 9, 10, 11, 12, 13, 14, 15, and 16. The medical modules of the human tissue scaffold are rectangular, T-shaped, L-shaped, and cross-shaped modules. The particle height is 0.5 cm. The medical modules can be spliced ​​into the required shape according to the actual needs of the surgery.

[0049] Please refer to Figures 9, 10, 11, 12, 13, 14, 15, and 16. The rectangular, T-shaped, L-shaped, and cross-shaped modules have several protrusions on one side, with a height of 0.2 cm. On the other side, perpendicular to the protrusions, several recesses are provided, with a depth of 0.2 cm. During surgery, the protrusions and recesses can be combined by interlocking to form tissue components.

[0050] Please refer to Figure 6. During the operation, rectangular modules, T-shaped modules, L-shaped modules, and cross-shaped modules are repeatedly spliced ​​according to the patient's actual situation to form multiple tissue components. Then, the tissue components are gradually spliced ​​into a tissue planar layer.

[0051] Please refer to Figure 3. Repeatedly splice multiple tissue plane layers. The length (x) and width (y) parameters of each tissue plane layer are the same as the length (x) and width (y) parameters of the corresponding layer of the specimen removed during surgery. Then, interlock two adjacent tissue plane layers and repeat this operation until the height (z). Implant the spliced ​​human tissue scaffold structure into the surgical cavity after resection, place a drain, and close the wound layer by layer.

[0052] The medical module material can be medical-grade metal or medical-grade silicone, or it can be a biodegradable biomaterial, including one or more of polylactic acid, polycaprolactone, chitosan, polyacetic acid-glycolic acid, polyvinyl alcohol, polyurethane, chitosan, and epoxidized acrylate copolymers. It has excellent biodegradability and can be gradually absorbed by the body after surgery, avoiding long-term foreign body reactions and promoting the patient's postoperative recovery.

Claims

1. A modular medical scaffold for human tissue (1, 13), characterized in that: The medical modular human tissue scaffold (1, 13) is composed of scaffold components (2, 14) and can flexibly and accurately fill tissue areas according to the actual shape of the removed tissue, thereby optimizing the postoperative recovery effect.

2. The medical modular human tissue scaffold according to claim 1, characterized in that: The bracket assembly (2) is assembled from the connector module (4) and the column module (5).

3. The medical modular human tissue scaffold according to claim 1, characterized in that: The bracket assembly (14) is composed of rectangular modules (7), T-shaped modules (8), L-shaped modules (9), and cross-shaped modules (10).

4. The medical modular human tissue scaffold according to claim 2, characterized in that: The connector module (4) has a socket (3) on its surface, which can be used to combine multiple cylindrical modules (5) with the socket (3) in a plug-in manner.

5. The medical modular human tissue scaffold according to claim 4, characterized in that: The insertion hole (3) can be precisely fitted to one end of the cylindrical module (5), and the connector module (4) and the cylindrical module (5) can be spliced ​​together during the operation according to the actual required quantity and volume and shape of the excised tissue.

6. The medical modular human tissue scaffold according to claim 3, characterized in that: The rectangular module (7), T-shaped module (8), L-shaped module (9), and cross-shaped module (10) are provided with several protrusions (11) on one side and several recesses (12) on the other side that are perpendicular and symmetrical to the protrusions (11). The protrusions (11) and recesses (12) can be combined by interlocking with each other.

7. The medical modular human tissue scaffold according to claim 6, characterized in that: The rectangular module (7), T-shaped module (8), L-shaped module (9), and cross-shaped module (10) have mutually compatible lengths, widths, and heights, and can be spliced ​​together during surgery according to the actual required quantity and volume and shape of the excised tissue.

8. The medical modular human tissue scaffold according to any one of claims 1-7, characterized in that: The medical module is made of medical-grade metal or medical-grade silicone material.

9. The medical modular human tissue scaffold according to any one of claims 1-7, characterized in that: The medical module splicing human tissue scaffold (1, 13) is a high molecular biomaterial that can be degraded in the human body.

10. The medical modular human tissue scaffold according to claim 9, characterized in that: The polymer biomaterial of the medical module splicing human tissue scaffold (1, 13) is one or more of polylactic acid, polycaprolactone, chitin, polyacetic acid-glycolic acid, polyvinyl alcohol, polyurethane, chitosan, and epoxidized acrylate copolymer.

11. The medical modular human tissue scaffold according to claim 2 or 3, characterized in that: The connector module (4) and the cross-shaped module (10) are internally embedded with titanium clips (6). The position and number of titanium clips (6) can be flexibly adjusted according to the specific shape of the tissue and the size of the residual cavity during the operation to ensure accurate positioning of postoperative radiotherapy.

12. The method for assembling a medical modular human tissue scaffold according to any one of claims 1-9, characterized in that, Includes the following steps: S1. Perform the resection surgery according to the scope of the preoperative clinical examination and imaging assessment; S2. Measure the length (x), width (y), and height (z) of the excised specimen or surgical cavity; S3. Assemble different medical modules into the required stent assembly according to the patient's actual needs; S4. Repeat step 3 to create multiple scaffold assemblies and assemble the multiple scaffold assemblies into a tissue plane layer; S5. Repeat steps 3 and 4 to splice multiple tissue plane layers, with the length (x) and width (y) of each tissue plane layer being the same as the length (x) and width (y) of the excised specimen; S6. Connect different tissue plane layers using modules, and repeat this operation until the height of z is reached, gradually splicing them into a human tissue scaffold module.

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