Oil-in-water type cosmetic composition embedded with visible oil particles carrying skin-beneficial ingredient

Abstract

The present invention relates to an oil-in-water type cosmetic composition in which visible dermacosmetic oil particles carrying skin-beneficial ingredients, such as compounds, peptides, or natural oils having skin regeneration, whitening, or antioxidant effects, are supported. More particularly, the present invention relates to an oil-in-water type cosmetic composition in which visible oil particles constituting an oil phase are dispersed in a continuous aqueous phase, wherein the aqueous phase includes an acrylic polymer and water, the oil phase includes an oil, a gelling agent, and a skin-beneficial ingredient, and the oil is a mixture of two or more oils including a low-viscosity oil and a high-viscosity oil. Utilizing the visible oil particles, the present invention can efficiently deliver the beneficial ingredients into the skin, exhibit various effects, including moisturizing, increased filaggrin production, skin whitening, and enhancement of the skin barrier, and also be applied to skin diseases such as atopic dermatitis and psoriasis. In addition, the composition maintains the stability of the emulsified particles and prevents mixing with other oils even without the use of surfactants or emulsifiers, exhibits low hardness and a low thixotropic index to provide a smooth application to the skin and maximum sensory properties, and offers aesthetic appeal, thereby enabling broad applications not only in cosmetics but also in the pharmaceutical field.

Description

Water-in-oil cosmetic composition containing visible oil particles having skin-beneficial ingredients

[0001] The present invention relates to an oil-in-water type cosmetic composition containing visible dermacosmetic oil particles that include skin-beneficial ingredients such as compounds, peptides, or natural oils that exhibit skin regeneration, whitening, or antioxidant efficacy.

[0002] Most cosmetics are provided in a form where water is dispersed in oil or oil is dispersed in water. To maintain a stable mixture, emulsifiers (surfactants) are required. These emulsifiers are located at the boundary between oil and water to reduce surface tension and form an interface between them, preventing particles from mixing. Without emulsifiers, the stability of oil particles decreases, and in some cases, problems such as increased skin irritation, oil greasiness, and poor spreadability may occur, leading to a decline in user experience.

[0003] However, commercial cosmetics require the use of emulsifiers with confirmed safety, which restricts the use of conventional synthetic surfactants. Furthermore, as even surfactants with confirmed safety are avoided by consumers due to concerns about skin irritation, there is a growing demand for the development of new cosmetic compositions that are surfactant-free.

[0004] Furthermore, along with the recent rise of functional cosmetics in the market, there is an increasing demand for visual aesthetics and differentiated user experiences. Reflecting this emotional demand, cosmetics containing beads, capsules, and particles with various colors and textures are being developed, leading to ongoing attempts to provide users with visual pleasure, aesthetic sensibility, and the joy of applying makeup.

[0005] The visible capsules typically used in the cosmetics industry are mostly those using carrageenan and agar, such as the cosmetic capsule composition disclosed in Korean Registered Patent Publication No. 10-0342357, or those using sodium alginate and alkali metal salts, as disclosed in Korean Patent Registration No. 10-0814034 (Patent Document 1). However, these capsules have the disadvantage of poor pressure disintegration and, after the capsule disintegrates, the constituent materials of the capsule are composed of water-soluble polymers, making them difficult to absorb into the skin.

[0006] Therefore, there is a need to develop a cosmetic composition that can maintain stable oil particles without using emulsifiers, protect the active ingredients of the cosmetic, improve the texture of the cosmetic, and enhance aesthetics. Accordingly, the present invention has manufactured oil capsule particles that enhance stability, safety, and aesthetics without using emulsifiers.

[0007] Prior Art: (Patent Document 1) KR10-0814034 B1 (March 10, 2008)

[0008] The main objective of the present invention is to provide a cosmetic composition containing oil capsule particles that maintain the stability of the emulsion particles without using emulsifiers or surfactants, protect active ingredients exhibiting specific efficacy, enhance aesthetic effects, and allow for gentle penetration into the skin. Furthermore, the invention provides a cosmetic composition containing oil capsule particles with enhanced functionality by incorporating various ingredients exhibiting effects such as skin regeneration, wound healing, whitening, antioxidant, and moisturizing into the oil capsule particles.

[0009] The present invention has been devised to solve the problems of the aforementioned prior art, and

[0010] As an oil-in-water type cosmetic composition in which visible oil particles in an oil phase are supported within a continuous phase aqueous phase,

[0011] The above aqueous phase comprises an acrylic acid-based polymer and water, and

[0012] The above oil phase comprises oil, a gelling agent, and a skin-beneficial ingredient, and

[0013] The present invention provides an oil-in-water type cosmetic composition characterized in that the above oil is a mixture of two or more types of oils, including low-viscosity oil and high-viscosity oil.

[0014] In addition, the present invention provides an oil-in-water type cosmetic composition characterized by a weight ratio of low viscosity oil to high viscosity oil within the range of 1 to 0.8 to 2.

[0015] In addition, the present invention provides an oil-in-water type cosmetic composition characterized in that the low-viscosity oil has a viscosity range of 100 cSt or less at 100°C.

[0016] In addition, in the present invention, the low-viscosity oil is isotridecyl isononanoate, PEG-4 diheptanoate, isostearyl neopentanoate, tridecyl neopentanoate, cetyl octanoate, cetyl palmitate, cetyl ricinoleate, cetyl stearate, cetyl myristate, cocodicaprylate / caprate, decyl isostearate, isodecyl oleate, isodecyl neopentanoate, isohexyl neopentanoate, octyl palmitate, dioctyl maleate, tridecyl octanoate, myristyl myristate, octyldodecanol, or a mixture of octyldodecanol, acetylated lanolin alcohol, cetyl acetate, isododecanol, polyglyceryl 3-diisostearate, or A water-in-water type cosmetic composition is provided, characterized by being a mixture thereof.

[0017] In addition, the present invention provides an oil-in-water type cosmetic composition characterized in that the high-viscosity oil has a viscosity range of more than 100 cSt at 100°C.

[0018] In addition, the present invention provides an oil-in-water type cosmetic composition characterized in that the high-viscosity oil is castor oil, lanolin and lanolin derivatives, triisocetyl citrate, sorbitan sesquioleate, C6-18 triglyceride, capryl / capric / triglyceride, coconut oil, corn oil, cottonseed oil, glyceryl triacetyl hydroxysterate, glyceryl triacetyl ricinoleate, glyceryl trioctanoate, hydrogenated castor oil, linseed oil, mink oil, olive oil, palm oil, rapeseed oil, soybean oil, sunflower oil, tallow, tricaprin, trihydroxystearin, triisostearin, trilaurin, trilinolein, trimyristin, triolein, tripalmitin, tristearin, walnut oil, wheat germ oil, cholesterol, or a mixture thereof.

[0019] In addition, the present invention provides an oil-in-water type cosmetic composition characterized in that the low-viscosity oil is isononyl isononanoate and the high-viscosity oil is capryl / capric triglyceride.

[0020] In addition, the present invention provides an oil-in-water type cosmetic composition characterized in that the gelling agent is a Caster Oil / IPDI copolymer.

[0021] In addition, the present invention provides an oil-in-water type cosmetic composition characterized by including 1 to 20 weight percent of the gelling agent relative to the total weight of the oil phase.

[0022] In addition, the present invention provides an oil-in-water type cosmetic composition characterized by substantially not including a surfactant that emulsifies the composition.

[0023] In addition, the present invention provides an oil-in-water type cosmetic composition characterized in that the acrylic acid-based polymer is a carbomer.

[0024] In addition, the present invention provides an oil-in-water type cosmetic composition characterized in that the average particle size of the visible oil particles is 10 to 100 μm.

[0025] In addition, the present invention provides an oil-in-water type cosmetic composition characterized in that the visible oil particles further comprise amodimethicone.

[0026] In addition, the present invention provides an oil-in-water type cosmetic composition characterized in that the aqueous phase further comprises one or more additional additives selected from polyhydric alcohols, humectants, alkali agents, skin-beneficial ingredients, preservatives, and pigments.

[0027] In addition, the present invention provides an oil-in-water type cosmetic composition characterized in that the skin-beneficial ingredient is ABT-751, CBD ceramide, Probarrier ceramide, PMWC, yuzu seed oil, or Hydroskin bond.

[0028] The present invention utilizes visible oil particles to efficiently deliver beneficial ingredients into the skin, and can exhibit various effects such as moisturizing, increased filaggrin production, whitening, and strengthening of the skin barrier, and can even be applied to skin diseases such as atopic dermatitis or psoriasis. Furthermore, the stability of the emulsion particles is maintained without the use of surfactants or emulsifiers, and mixing with other oils is prevented. It also exhibits low hardness and a thixotropy index, allowing it to spread smoothly on the skin and maximize user experience, as well as provide aesthetic appeal, so it can be utilized in various fields not only in cosmetics but also in the pharmaceutical sector.

[0029] Figure 1 shows the results of evaluating the cellular efficacy of ABT-751 in increasing filaggrin expression.

[0030] Figure 2 shows the results of evaluating the cellular efficacy of CBD Ceramide.

[0031] Figure 3 shows the results of evaluating the efficacy of Probarrier Ceramide on the skin.

[0032] Figure 4 shows the results of evaluating the cellular efficacy of PMWC.

[0033] Figure 5 shows the results of evaluating the efficacy of PMWC on the skin.

[0034] Figure 6 shows the results of evaluating the efficacy of yuzu seed oil DP on the skin.

[0035] Figure 7 shows the results of evaluating the efficacy of Hydroskin Bond on the skin.

[0036] Figure 8 shows the visual identification shape of the ABT-751 oil particle formulation formed according to Example 1.

[0037] Figure 9 is a photograph of the visually identifiable form of the CBD ceramide oil particle formulation formed according to Example 1.

[0038] Figure 10 is a photograph of the visually identifiable form of the probarrier ceramide oil particle formulation formed according to Example 1.

[0039] Figure 11 is a photograph of the visually identifiable form of the PMWC oil particle formulation formed according to Example 1.

[0040] Figure 12 is a photograph of the visually identifiable form of the yuzu seed oil DP oil particle formulation formed according to Example 1.

[0041] Figure 13 is a photograph of the visually identifiable form of the Hydro-SkinBond™ oil particle formulation formed according to Example 1.

[0042] The present invention will be described in detail below.

[0043]

[0044] One aspect of the present invention is,

[0045] As an oil-in-water type cosmetic composition in which visible oil particles in an oil phase are supported within a continuous phase aqueous phase,

[0046] The above aqueous phase comprises an acrylic acid-based polymer and water, and

[0047] The above oil phase comprises oil, a gelling agent, and a skin-beneficial ingredient, and

[0048] The above oil is characterized by being a mixture of two or more types of oil, including low-viscosity oil and high-viscosity oil.

[0049] The above 'in-water type' refers to an emulsion in which oil droplets are dispersed in water, and is also called an o / w type emulsion; typical examples include milk, mayonnaise, and vanishing cream.

[0050] The above 'visible oil particles' refer to particles that are identifiable with the naked eye, and the average particle size of the visible oil particles may be 10 µm or more, 20 µm or more, 50 µm or more, 100 µm or more, 500 µm or more, 800 µm or more as a lower limit, and 5000 µm or less, 4500 µm or less, or 4000 µm or less as an upper limit. Specifically, it may be 10 to 5000 µm, and more specifically, it may be 20 to 4500 µm, 50 to 4000 µm, or 100 to 3000 µm. The visible oil particles may have excellent colloidal stability while having the large average particle size described above, and may have a transparent or translucent phase by controlling the refractive index of the oil phase and the water phase. If the average particle size of the visible oil particles is less than 10 μm, even though the dispersion stability is excellent, it may not be desirable because it transitions from a translucent phase to an opaque phase, resulting in an undesirable appearance.

[0051] The volume ratio of the above aqueous phase and the visible oil particles is not limited as long as the aqueous phase is included in an equal or greater volume than the oil phase. More specifically, it may be 50:50 to 99:1, 55:45 to 95:5, 55:45 to 90:10, 60:40 to 85:15, 60:40 to 80:20, or 60:40 to 80:20.

[0052] The acrylic acid-based polymer included in the aqueous phase may be a hydrophobic substituent acrylic acid-based polymer, which is a water-soluble polymer containing acrylic acid residues in its structural units. Specifically, the hydrophobic substituent acrylic acid-based polymer may be a long-chain alkyl group-substituent acrylic acid-based polymer, and exemplarily, may be a carbomer. Preferably, the hydrophobic substituent acrylic acid-based polymer may be a C14 or higher, specifically a C16 to C20 long-chain alkyl group-substituent acrylic acid-based polymer, and exemplarily, may be Carbomer 940 or Carbomer 980. The above carbomer is an anionic polymer, in which an acidic polymer compound is polymerized mainly to acrylic acid, and may be preferably selected as it has the effect of maintaining stability by increasing the viscosity of the disclosed oil-in-water type cosmetic composition.

[0053] The acrylic acid-based polymer contained in the above aqueous phase may be present in an amount of 0.01 to 20 parts by weight, 0.01 to 10 parts by weight, or 0.03 to 1 part by weight per 100 parts by weight of water. If the amount falls outside the above range, the viscosity may fall outside the desirable range for the cosmetic composition, and consequently, the usability or aesthetic appeal may be reduced when the cosmetic is applied to the skin.

[0054] The above aqueous phase may further include additional additives such as polyhydric alcohols, wetting agents, or alkali agents to further improve the stability of visible oil particles.

[0055] Examples of the above polyhydric alcohols include C2 to C20, specifically C4 to C16 dihydric to pentahydric alcohols, and specifically, C4 to C16 dihydric to pentahydric alcohols can be used without limitation as long as they can be used in a skin external composition, and non-limiting examples thereof may be one or more selected from propanediol, butylene glycol, 1,2-butanediol, 1,3-butanediol, 2,3-butanediol, 2-methyl-1,3-propanediol, 1,2-hexanediol, trimethylolethane, trimethylolpropane, pentaerythritol, sorbitol, mannitol, xylitol, erythritol, adonitol, threitol, arabitol, and thalitol.

[0056] The above-mentioned humectant may have the effect of increasing stability by absorbing water and increasing the viscosity and flexibility of the water, and representative humectants include glycerin types such as glycerin, ethylhexylglycerin, and glycerin acetate; polyhydric alcohols such as propylene glycol; sugar alcohols such as sorbitol, xylitol, and maltitol; polydextrose; and natural substances such as quillaja extract, lactic acid, and urea.

[0057] Non-limiting examples of the above alkali agent include one or more selected from sodium hydroxide, potassium hydroxide, ammonium hydroxide, arginine, tromethamine, and triethanolamine. When an alkali agent is included in the aqueous phase, the (meth)acrylic acid structural units within the acrylic acid-based polymer present in the aqueous phase are deprotonated by the neutralization process of the alkali agent, thereby further improving the stability of the visible oil particles.

[0058] Examples of oils included in the above oil phase include silicone oil, hydrocarbon oil, ester oil, triglyceride oil, vegetable oil, animal oil, mineral oil, natural oil, or combinations thereof, but are not necessarily limited thereto.

[0059] The above ester-based oil may be an aliphatic oil containing one or more ester bonds, and specifically, may be one or more selected from triethylhexanoin, cetylethylhexanoate, cetyloctanoate, cetylisooctanoate, isononyl isononanoate, octyldodecyl myristate, pentaerythrityltetraethylhexanoate, isopropyl palmitate, isopropyl myristate, tocopherol acetate, etc., but is not limited thereto.

[0060] The above triglyceride-based oil may be one or more selected from C8-C12 acid triglycerides, C12-C18 acid triglycerides, caprylic / capric triglycerides, caprylic / capric / lauric triglycerides, C10-C40 isoalkyl acid triglycerides, C10-C18 triglycerides, glyceryl triacetyl hydrostearate, soybebin glycerides, tribehenin, tricaprin, triethylhexanoin, triheptanoin, triisostearin, tripalmitin, or tristeaarin, but is not limited thereto.

[0061] In particular, in the present invention, two or more types of oils, such as low-viscosity oil and high-viscosity oil, are mixed and used. By doing so, the stability of the particles is high during storage, but fluidity increases and particle disintegration is increased during pressurization. This can contribute to exhibiting desirable thixotropic properties. Furthermore, depending on the combination of low-viscosity oil and high-viscosity oil, visible oil particles dispersed in the aqueous phase can have superior dispersion stability, and a structure of visible oil particles in which oil is located inside and a hydrophobic polymer forms a capsule wall material can be effectively formed.

[0062] In the same respect, the ratio of low-viscosity oil to high-viscosity oil may also be important, and the weight ratio of low-viscosity oil to high-viscosity oil may be within the range of 1:0.8 to 2, preferably low-viscosity oil to high-viscosity oil = 1:1 to 1.8, and more preferably low-viscosity oil to high-viscosity oil = 1:1.2 to 1.6.

[0063] The above low-viscosity oil refers to an oil having a viscosity range of 100 cSt or less at 100°C, and non-limiting examples thereof include isononyl isonanoate, isotridecyl isononanoate, PEG-4 diheptanoate, isostearyl neopentanoate, tridecyl neopentanoate, cetyl octanoate, cetyl palmitate, cetyl ricinoleate, cetyl stearate, cetyl myristate, cocodicaprylate / caprate, decyl isostearate, isodecyl oleate, isodecyl neopentanoate, isohexyl neopentanoate, octyl palmitate, dioctyl maleate, tridecyl octanoate, myristyl myristate, octyldodecanol, or a mixture of octyldodecanol. Examples include acetylated lanolin alcohol, cetyl acetate, isododecanol, polyglyceryl 3-diisostearate, or a mixture thereof, and isononyl isononanoate may be preferably selected.

[0064] The above high-viscosity oil refers to an oil having a viscosity range of more than 100 cSt at 100°C, and as a non-limiting example, the above high-viscosity oil includes castor oil, lanolin and lanolin derivatives, triisocetyl citrate, sorbitan sesquioleate, C6-18 triglycerides, capryl / capric / triglycerides, coconut oil, corn oil, cottonseed oil, glyceryl triacetyl hydroxysterate, glyceryl triacetyl ricinoleate, glyceryl trioctanoate, hydrogenated castor oil, linseed oil, mink oil, olive oil, palm oil, rapeseed oil, soybean oil, sunflower oil, tallow, tricaprin, trihydroxystearin, triisostearin, trilaurin, trilinolein, trimyristin, triolein, tripalmitin, tristearin, walnut Examples include oil, wheat germ oil, cholesterol, or a mixture thereof, and caprylic / capric triglyceride (MCT oil) may be preferably selected.

[0065] The above gelling agent is a component capable of imparting transparent or translucent properties to visible oil particles while having the characteristics of a viscoelastic solid, and a known gelling agent widely used in the relevant technical field may be used. For example, a hydrophobic polymer containing C14 or more aliphatic groups may be one or more combinations selected from the group consisting of graft-type polysaccharides containing C14 or more aliphatic groups, condensates of polyalcohol-based compounds and polyisocyanates, and graft-type polyolefins containing C14 or more aliphatic groups. More specific examples include DPEH (dextrin palmitate ethylhexanoate), DM (dextrin myristate), polyacrylates, dextrin and fatty acid esters, esters of glycerol and fatty acids, one or more selected from the polyamide and glutamide groups, or condensates of polyalcohol compounds and polyisocyanates, wherein polyalcohol compounds and polyisocyanates are polymerized by condensation via urethane bonds, such as hexamethylene diisocyanate / trimethylol hexyllactone crosspolymer (HDI / Trimethylol Hexyllactone Crosspolymer), condensates of castor oil and alicyclic polyisocyanates, and mixtures of condensates of polyalcohol compounds and alicyclic polyisocyanates; however, in terms of maintaining the stability of visible oil particles in the oil phase and exhibiting desirable thixotropic properties, Caster An oil / IPDI copolymer may be preferably selected.

[0066] The gelling agent may be included in an amount of 1 to 20 weight percent relative to the weight of the oil phase. If the gelling agent is included in an amount less than the above range, there may be a risk that the hardness of the surface of the oil particles becomes too low and the particles may coalesce, and if the gelling agent is included in an amount greater than the above range, there may be a possibility of adverse effects on the disintegration or aesthetics of the visible oil particles.

[0067] The water-in-oil type cosmetic composition of the present invention may substantially not contain an emulsifying surfactant. As described above, conventional emulsification systems and visible oil particle compositions must contain a large amount of alcohol or a surfactant to ensure colloidal stability; however, the visible oil particle composition according to the present invention may substantially not contain a surfactant for emulsifying the aqueous and oil phases. By not containing a surfactant, it may have significantly superior skin safety, and accordingly, consumer preference may be further enhanced.

[0068] However, in the present invention, the fact that a surfactant is not substantially included means that it is not included within a range that substantially affects the stability, spreadability, aesthetics, or the effect of the skin-beneficial ingredients of the visible oil particle composition, and it merely means that there is no need to intentionally add a separate surfactant to improve the stability of the water-in-oil type composition, and that it is not added. It does not completely exclude cases where it is incorporated as an impurity, where it is included in small amounts together with other ingredients such as skin-beneficial ingredients, where the skin-beneficial ingredients themselves can also act as surfactants, or where it is included in trace amounts for other known additional effects.

[0069] Specifically, the surfactant may be included in an amount of about 0.1% by weight or less, preferably about 0.01% by weight or less, more preferably about 0.001% by weight or less, or even more preferably about 0.0001% by weight or less, based on the total weight of the cosmetic composition, and may be 0% by weight or more as a lower limit.

[0070] The above-mentioned visible oil particles may further contain amodimethicone to enhance stability or usability. Amodimethicone has a wax-like consistency yet exhibits excellent compatibility with water, allowing it to thicken the water and improve adhesion to the skin. In other words, it can increase stability and improve skin usability in oil-in-water formulations.

[0071] The above amodimethicone may be further included in an amount of 0.001 to 0.7% by weight or 0.01 to 0.6% by weight based on the total weight of visible oil particles, and may be an oil-in-water type cosmetic composition including 0.1 to 0.5% by weight suitable for improving adhesion when applied to the skin, but is not necessarily limited thereto.

[0072] The above-mentioned skin-beneficial ingredients are components supported within the visible oil particles, and conventionally widely known skin-beneficial ingredients may be used without limitation. However, in the present invention, visible surfactant-free oil particles were prepared to support various raw materials such as ABT-751, PMWC, pseudo-synthetic ceramide, natural materials, and Hydroskinbond, an alginate / cellulose nanofiber composite, and cosmetic compositions were prepared exhibiting efficacy in skin barrier regeneration, whitening, antioxidant, and filaggrin regeneration, respectively. These skin-beneficial ingredients demonstrated high stability and efficacy within the cosmetic compositions. A more detailed understanding of this can be achieved through the examples and experimental examples described below.

[0073] In addition, the present invention exemplifies skin-beneficial ingredients such as ABT-751, CBD ceramide, Probarrier ceramide, PMWC, yuzu seed oil DP, Hydroskin bond™, or mixtures thereof, but is not necessarily limited thereto.

[0074] Here, 'ABT-751' is a sulfonamide physiological compound of Cas No. 141430-65-1, which is known to have cancer cell inhibitory efficacy by effectively preventing cell division by inducing cell cycle arrest and apoptosis, and by inducing autophagy by inhibiting the AKT / MTOR signaling pathway.

[0075] 'CBD Ceramide' is Cas No. 72809-08-6, a substance known for its skin soothing and moisturizing effects, having a structure similar to Endocanabinoid and Ceramide found in the human body.

[0076] 'Probarrier Ceramide' is Cas No. 211184-47-3, an effective and safe ceramide that mimics endocannabinoids produced in the body, and is known for its efficacy in increasing hyaluronic acid production and improving skin hydration.

[0077] 'PMWC' is a compound developed through a combination of naturally occurring phenolic acids and amino acids, with Cas No. 1995866-83-5, and is a substance that performs a whitening effect by regulating melanin-producing transcription factors.

[0078] 'Yuzu Seed Oil DP' is a naturally derived oil obtained by pressing yuzu seeds.

[0079] 'Hydroskin bond™' is a compound composed of Phenylboronic Acid Alginate Amide and Cellulose Hydroxypropyltrimonium Chloride, and is a green bio cellulose hydrogel skin bioadhesive material that guarantees the closure of micro-wounds and the strengthening of the skin barrier.

[0080]

[0081]

[0082] The present invention will be described in more detail below through embodiments and test examples. However, it should be clarified that the following embodiments are intended only for the detailed description of the invention and are not intended to limit the scope of the rights.

[0083]

[0084] Examples

[0085] The aqueous phase and the oil phase were prepared according to the formulations shown in Table 1 below, and the oil phase was stirred and dispersed into the aqueous phase in a tank. During mixing, the temperature inside the tank was maintained in the range of approximately 60 to 90°C, and for Examples 1, 4 to 6 and the Comparative Example, a membrane emulsification device was used, while for Examples 2 and 3, an injection method using a capillary tube such as a syringe was used for the oil phase into the aqueous phase.

[0086] (Unit: Weight %) Ingredients Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Comparative Example Oil Phase Carylic / Capric Triglyceride 5.494 5.394 5.394 5.394 8.494 8.494 9.0 Isononyl Isononanoate 4.44466 - Gelling Agent Castor Oil / IPDI Compolymer 0.4 - Dextrin palmitate / Ethylhexanoate 1.0 Colorant Natural Colorant 0.06 0.10.10.1 --- Antifoaming Humectant Amodimethicone 0.006 - Useful Ingredient ABT-75 10.1------CBD Ceramide-0.1-----Probarrier Ceramide--0.1----PMWC---0.1---Yuzu Seed Oil dp----0.1--Hydro Skinbond™-----0.1-Aqueous Water Acrylic Polymer Carbomer 0.15 Water Purified Water 75.59 75.65 75.65 75.65 70.55 70.65 75.65 Polyhydric Alcohol Propanediol 5 1,2-Hexanediol 2 Butylene Glycol 3 Humectant Glycerin 2 Preservative Ethylhexylglycerin 0.05 Alkaline Arginine 0.15 Useful Ingredient Niacinamide 2 Color Natural Color ----0.1--

[0087] Test example

[0088] Evaluation of the skin benefits of ABT-751

[0089] Efficacy evaluations were performed by treating cultured NHEK with ABT-751 to measure filaggrin expression levels and confirm changes in cell differentiation. ABT-751 was applied to NHEK at different concentrations (0, 0.5, 1, 2.5 μM), and an increase in filaggrin expression and cell differentiation was observed 24 hours after treatment (Fig. 1).

[0090] It was confirmed that the experimental group treated with ABT-751 showed increased filaggrin expression and cell differentiation compared to the control group not treated with ABT-751; in particular, it was observed that filaggrin expression increased in a concentration-dependent manner. As filaggrin is a component related to skin moisturization, beneficial effects regarding skin hydration can be confirmed.

[0091]

[0092] Evaluation of the Skin Benefits of CBD Ceramide

[0093] In an experiment using HaCaT cells, to measure the hyaluronic acid (HA) production effect, the cells were treated with a medium containing CBD Ceramide and cultured for 24 hours. The supernatant of the cultured cells was then collected, and the amount of hyaluronic acid was measured using a Hyaluronan Quantikine ELISA kit (Fig. 2).

[0094] It was confirmed that the production of HA increased by approximately 33.3% when treated with 20 μg / mL of CBD skin barrier enhancer. Hyaluronic acid (HA) is an ingredient related to skin moisturization, and its useful effects in relation to skin moisturization can be confirmed.

[0095]

[0096] Evaluation of the skin benefits of Probarrier Ceramide

[0097] Probarrier Ceramide, the test product, was applied to a selected test site (1.5 cm * 1.5 cm) of the forearm using a micro pipette. The average value was calculated using four values. Measurements were taken immediately before and after product application, and after 1 hour, 3 hours, 5 hours, and 7 hours.

[0098] It was confirmed that the skin moisture content and TEWL of the Probarrier Ceramide-containing cream were increased compared to the control NP ceramide-containing cream (Fig. 3).

[0099]

[0100] Evaluation of PMWC's Skin Benefits 1

[0101] To evaluate the whitening efficacy on skin melanocytes, B16F10 cells were seeded into a 24-well plate at a density of 2.0 × 10⁴ cells / well and cultured for 24 hours. Subsequently, α-MSH (200 nM) and PMWC samples were added simultaneously, and the cells were cultured for 72 hours. After the culture was complete, the cells were washed with phosphate buffer (pH 7.4) and harvested into 1.5 mL e-tubes. Next, 1N NaOH was added and reacted for 1 hour, after which the absorbance was measured at 405 nm. Arbutin (500 μg / mL) was used as a positive control.

[0102] Experimental results confirmed that melanin production increased upon α-MSH stimulation and that intracellular melanin production decreased upon PMWC treatment (Fig. 4). Thus, useful effects as a component related to skin whitening effects can be confirmed.

[0103]

[0104] Evaluation of PMWC's Beneficial Skin Efficacy 2

[0105] To confirm the whitening efficacy in actual tissues, 0.1% PMWC cream was applied to the skin of participants induced by UVB and observed for 8 weeks.

[0106] As a result, it was confirmed that melanin production was inhibited and whitening effects were observed in the eye area irradiated with UVB (Fig. 5). Thus, useful effects as a component related to skin whitening effects can be confirmed.

[0107]

[0108] Evaluation of the skin benefits of Yuzu seed oil DP

[0109] Moisture content was measured on the forearm using a Corneometer (CM825, Courage and Khazaka Electronic Co., Germany), and the average value was calculated using three measurements. The test product, Yuzu Seed Oil DP, was applied to a selected test area (1.5 cm * 1.5 cm) on the forearm at a rate of 2 µl / cm² using a micro pipette. Measurements were taken before, immediately after, 4 hours after, and 8 hours after product application. Before each measurement, the measurement area was lightly wiped with kim wipes. The Corneometer measures the capacitance of the current transmitted through a probe in contact with the skin. Since moisture content and capacitance are proportional to each other, the higher the moisture content, the higher the measured value; the measurement factor is an Arbitrary Unit (AU).

[0110] As a result of measuring the moisture of the yuzu seed oil DP, it was confirmed that there was a change in moisture, with 59 2 AU immediately after application, 5 1 2 AU after 4 hours, and 4 5 0 AU after 8 hours. Compared to the unapplied area, the yuzu seed oil DP showed statistically significant improvement in moisture immediately after application, 4 hours after, and 8 hours after application, as well as an 8-hour moisturizing effect (Fig. 6).

[0111]

[0112] Evaluation of the skin benefits of Hydroskin Bond™

[0113] To induce skin barrier damage by optical stimulation, ultraviolet rays were irradiated using a Multiport Solar Simulator, 601 300W (Solar Light, USA). The area to be tested was marked on the right forearm of the subject, which had no discoloration or skin damage, and ultraviolet rays with the same amount of light (650 μW / cm²) were irradiated for 1 minute 30 seconds (±10 seconds).

[0114] The recovery of skin barrier damage caused by optical stimulation was measured using a Vapometer (Delfin Technologies Ltd, Finland). The same right forearm was measured before UV irradiation, 24 hours after UV irradiation, and 2 weeks after using the test product. It was confirmed that there was a statistically significant increase 24 hours after UV irradiation and a statistically significant improvement 2 weeks after use compared to 24 hours after UV irradiation.

[0115] To induce skin barrier damage through physical stimulation, an area to be tested was marked on the subject's left forearm, which was free of discoloration or skin damage, and skin damage was induced by repeatedly attaching and removing a special film (TS: Tape Stripping).

[0116] The recovery of skin barrier damage caused by physical stimulation was measured using a Vapometer (Delfin Technologies Ltd, Finland), and the same left forearm was measured immediately after using the test product before and after TS.

[0117] The measurement unit is g / ㎡·h, and it was confirmed that as the measurement value decreases, it is effective in restoring skin barrier damage caused by physical stimulation.

[0118]

[0119] thixotropic measurement

[0120] Thixotropic properties were measured for Examples 1 and 5 and the Comparative Example. The results are as shown in Table 2 below.

[0121] Test Item Unit Test Method Shear Rate Test Result Example 1 Viscosity Pa·s Analysis using a rotary rheometer 0.5 (1 / s) 628 Viscosity Pa·s 5 (1 / s) 48.4 Rhythmic Index --13.0 Example 5 Viscosity Pa·s 0.5 (1 / s) 641 Viscosity Pa·s 5 (1 / s) 60.0 Rhythmic Index --10.7 Comparative Example Viscosity Pa·s 0.5 (1 / s) 7820 Viscosity Pa·s 5 (1 / s) 428 Rhythmic Index --18.3 Note: a) Temperature: 25℃ b) Shear rate: (0.05~1,000) 1 / sc) Measuring geometry: 25㎜ plated)

[0122] As confirmed in Table 1 above, Examples 1 and 5 showed lower thixotropy indices compared to the comparative example, confirming that the visible oil particles have high stability during storage, prevent sedimentation, and have good disintegration properties when applied.

Claims

1. A water-in-oil type cosmetic composition in which visible oil particles in an oil phase are supported within an aqueous phase in a continuous phase, The above aqueous phase comprises an acrylic acid-based polymer and water, and The above oil phase comprises oil, a gelling agent, and a skin-beneficial ingredient, and An oil-in-water type cosmetic composition characterized in that the above oil is a mixture of two or more types of oils, including low-viscosity oil and high-viscosity oil.

2. An oil-in-water type cosmetic composition according to Claim 1, characterized in that the weight ratio of low viscosity oil to high viscosity oil is within the range of 1 to 0.8 to 2.

3. An oil-in-water type cosmetic composition according to claim 1, wherein the low-viscosity oil has a viscosity range of 100 cSt or less at 100°C.

4. In claim 1, the low-viscosity oil comprises isotridecyl isononanoate, PEG-4 diheptanoate, isostearyl neopentanoate, tridecyl neopentanoate, cetyl octanoate, cetyl palmitate, cetyl ricinoleate, cetyl stearate, cetyl myristate, cocodicaprylate / caprate, decyl isostearate, isodecyl oleate, isodecyl neopentanoate, isohexyl neopentanoate, octyl palmitate, dioctyl maleate, tridecyl octanoate, myristyl myristate, octyldodecanol, or a mixture of octyldodecanol, acetylated lanolin alcohol, cetyl acetate, isododecanol, A water-in-oil type cosmetic composition characterized by being polyglyceryl 3-diisostearate or a mixture thereof.

5. An oil-in-water type cosmetic composition according to Claim 1, wherein the high-viscosity oil has a viscosity range of more than 100 cSt at 100°C.

6. The oil-in-water type cosmetic according to Claim 1, wherein the high-viscosity oil is castor oil, lanolin and lanolin derivatives, triisocetyl citrate, sorbitan sesquioleate, C6-18 triglyceride, capryl / capric / triglyceride, coconut oil, corn oil, cottonseed oil, glyceryl triacetyl hydroxysterate, glyceryl triacetyl ricinoleate, glyceryl trioctanoate, hydrogenated castor oil, linseed oil, mink oil, olive oil, palm oil, rapeseed oil, soybean oil, sunflower oil, tallow, tricaprin, trihydroxystearin, triisostearin, trilaurin, trilinolein, trimyristin, triolein, tripalmitin, tristearin, walnut oil, wheat germ oil, cholesterol, or a mixture thereof. Composition.

7. An oil-in-water type cosmetic composition according to Claim 1, characterized in that the low-viscosity oil is isononyl isononanoate and the high-viscosity oil is capryl / capric triglyceride.

8. An oil-in-water type cosmetic composition according to Claim 1, characterized in that the gelling agent is a Caster Oil / IPDI copolymer.

9. An oil-in-water type cosmetic composition according to Claim 1, characterized in that the gelling agent comprises 1 to 20 weight percent based on the total weight of the oil phase.

10. An oil-in-water type cosmetic composition according to Claim 1, characterized in that it substantially does not contain a surfactant that emulsifies the composition.

11. An oil-in-water type cosmetic composition according to Claim 1, characterized in that the acrylic acid-based polymer is a carbomer.

12. An oil-in-water type cosmetic composition according to Claim 1, characterized in that the average particle size of the visible oil particles is 10 to 100 μm.

13. An oil-in-water type cosmetic composition according to Claim 1, characterized in that the visible oil particles further comprise amodimethicone.

14. An oil-in-water type cosmetic composition according to Claim 1, wherein the aqueous phase further comprises one or more additional additives selected from polyhydric alcohols, humectants, alkali agents, skin-beneficial ingredients, preservatives, and pigments.

15. An oil-in-water type cosmetic composition according to Claim 1, characterized in that the skin-beneficial ingredient is ABT-751, CBD ceramide, Probarrier ceramide, PMWC, yuzu seed oil, or Hydroskin bond.

Images