Novel dyes
Novel BODIPY dyes with improved stability address thermal and photochemical limitations, facilitating effective biomolecular labeling and sequencing by detecting luminescence characteristics.
AU2025205659A1Pending Publication Date: 2026-07-16QUANTUM SI INC
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Patent Information
- Application Number
- AU2025205659
- Authority / Receiving Office
- AU · AU
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-01-05
- Filing Date
- 2025-01-03
- Publication Date
- 2026-07-16
AI Technical Summary
Technical Problem
BODIPY dyes used for biomolecular labeling face challenges such as thermal instability, photochemical instability, photobleaching, and dye-dye interactions, limiting their effectiveness in complex biological systems, and existing synthesis methods yield low chemical products.
Method used
Development of novel BODIPY dyes with improved thermal and photochemical stability, designed for biomolecular labeling, and a method for sequencing polypeptides using amino acid recognition molecules that detect luminescence intensity and lifetime.
Benefits of technology
The novel BODIPY dyes exhibit enhanced stability and differentiation capabilities, enabling effective biomolecular labeling and sequencing by distinguishing amino acid residues based on luminescence properties.
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Abstract
Provided herein are compounds of Formula (I). Also provided herein are amino acid recognition molecules, and salts thereof, comprising at least one instance of Formula (II), and compositions thereof. Further provided herein are methods of sequencing a polypeptide using an amino acid recognition molecule, or salt thereof, comprising at least one instance of Formulae (II) or (IV).
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