A simple and retractable inhalation anesthesia device for mice

Abstract

The present invention relates to a simple and retractable mouse inhalation anesthesia device, comprising an anesthetic placement portion, an operation fixation plate and an anesthesia cabin; the anesthesia cabin comprises a front end interface, a retractable bellows, a cylinder and a tail base; the retractable bellows is sequentially connected to the cylinder and the tail base, a double-valve silicone sleeve is provided on the tail base, and the double-valve silicone sleeve is used to seal the anesthesia cabin; the inner wall of the cylinder is provided with two chutes; both sides of the operation fixation plate cooperate with the chutes, and the double-valve silicone sleeve is provided with a linear opening corresponding to the operation fixation plate; the anesthetic placement portion comprises a hollow cylinder and an end cap; one end of the hollow cylinder is closed, and a hollow hole is provided on the closed end, and the end cap is used to seal the hollow cylinder; one end of the hollow cylinder provided with the hollow hole is connected to the front end interface of the anesthesia cabin. During use, the present invention does not require operations such as fixing the mouse in a conscious state and tightening the strap, and the mouse can be directly placed inside the device for anesthesia induction.

Description

Technical Field

[0001] The invention relates to a simple and retractable mouse inhalation anesthesia device. Background Art

[0002] Mice are commonly used experimental animals in the field of scientific research. Due to animal ethics requirements and taking into account the biological characteristics of mice with agile movements, mice often need to be anesthetized when conducting some experiments. Compared with intraperitoneal injection anesthesia, isoflurane gas inhalation anesthesia has faster anesthesia induction and awakening, and a lower mortality rate. It is a safer and more efficient anesthesia method. However, isoflurane inhalation anesthesia often requires a gas anesthesia machine to anesthetize mice through an air pump. Existing anesthesia machines are expensive and not easy to carry. In the absence of anesthesia machines or when anesthesia machines are difficult to carry, experimenters cannot use isoflurane gas to anesthetize experimental animals quickly and safely. Therefore, it is very necessary to find a simple and portable anesthesia device.

[0003] The Chinese utility model patent with application number 202123386439.7 discloses a simple anesthesia device for mice. When it is used, the awake mouse needs to be fixed on the mouse trap before inducing anesthesia. The process of fixing the mouse awake is a great stress to the mouse, which in turn affects the experimental indicators and greatly increases the risk of the experimenter being bitten by the mouse. Therefore, in fact, this solution is not practical. At the same time, the position of the strap affects operations such as surgery, and the tightness of the fixing strap varies from person to person, causing problems such as suffocation of the mouse and the risk of internal organs being compressed. Summary of the Invention

[0004] The present invention proposes a simple and retractable mouse inhalation anesthesia device. During use, the mouse does not need to be fixed or strapped tight in a conscious state, and can be directly placed inside the device for induced anesthesia.

[0005] The technical solution of the present invention to solve the above problems is: a simple and retractable mouse inhalation anesthesia device, which is special in that:

[0006] Including anesthetic placement unit, surgical fixation board and anesthesia cabin;

[0007] The anesthesia cabin includes a front interface, a retractable bellows and a rear base;

[0008] The front interface is connected to the front end of the telescopic bellows through a conical cover, and the rear end of the telescopic bellows is provided with a cylinder; the tail base is a hollow cylinder, one end of which is nested and connected to the cylinder, and the other end is provided with a curling edge, and a double-valve silicone sleeve is sleeved on the curling edge, and the double-valve silicone sleeve is used to seal the anesthesia cabin; the inner wall of the cylinder is provided with two sliding grooves;

[0009] Both sides of the surgical fixation plate cooperate with the slide grooves respectively so that the surgical fixation plate can be translated in the anesthesia cabin. The double-valve silicone sleeve is provided with a linear opening corresponding to the surgical fixation plate, and the surgical fixation plate can extend out of the anesthesia cabin from the linear opening.

[0010] The anesthetic placement part includes a hollow cylinder and an end cover; one end of the hollow cylinder is closed, and a hollow hole is provided on the closed end. The end cover is arranged at the other end of the hollow cylinder to seal the hollow cylinder; the end of the hollow cylinder with the hollow hole is connected to the front end interface of the anesthesia cabin.

[0011] Furthermore, the above-mentioned front-end interface is a cylindrical structure with one end closed, and a hollow hole is provided on the closed end. The hollow cylinder is rotatably connected to the front-end interface of the anesthesia cabin, and the closed ends of the two are in contact. By rotating the cylindrical structure, the area of ​​overlap between the hollow cylinder and the hollow hole in the front-end interface can be adjusted.

[0012] Furthermore, the hollow cylindrical end of the above-mentioned anesthetic placement part is provided with a buckle, and the side wall of the front end interface is provided with a buckle groove that cooperates with the buckle of the hollow cylindrical end. Through the cooperation of the buckle and the buckle groove, the hollow cylinder and the front end interface of the anesthesia cabin are rotated and connected.

[0013] Furthermore, the surgical fixation plate is provided with a platform on one side close to the front end interface, and a tooth socket is provided in the platform to fix the mouse incisors.

[0014] Furthermore, the above-mentioned surgical fixation plate is provided with a fixing frame on one side close to the front end interface, and the fixing frame includes two columns, the tops of the two columns are respectively connected to a horizontal cross bar, and the ends of the two horizontal cross bars are connected to a U-shaped structure. The fixing frame can fix the mouse incisors, and the fixing frame is suitable for fixing the mouse when it is in a supine position.

[0015] Furthermore, two supporting legs are respectively provided below the conical cover and the cylinder.

[0016] Furthermore, an air path interface is provided on the end cover, which allows air to flow into the anesthesia cabin body, and can also be connected to compressed air or oxygen, or to a gas anesthesia machine.

[0017] Furthermore, the conical cover, cylinder, retractable bellows and tail base are all made of transparent materials.

[0018] Furthermore, the cone cover, cylinder and tail base are all made of transparent hard plastic.

[0019] Furthermore, the hollow holes in the hollow cylinder and the front end interface are six fan-shaped hollow holes.

[0020] Advantages of the present invention:

[0021] 1. The present invention proposes a simple and retractable mouse inhalation anesthesia device, which can reduce the stress response induced by anesthesia and enhance the continuity between anesthesia induction and anesthesia maintenance.

[0022] 2. During use of the present invention, there is no need to fix or tighten the straps while the mouse is awake. The mouse is directly placed inside the device to induce anesthesia.

[0023] 3. During use, the present invention can complete anesthesia induction and anesthesia maintenance in short surgical experimental operations in the same device, meeting the needs of anesthesia induction and maintenance of anesthesia continuity in short surgical operations on mice, and thus can solve the problem of not being able to obtain anesthesia machines in time during short surgical anesthesia (anesthesia machines and other devices are expensive and bulky and often cannot be obtained in time). It has the advantages of simple operation, small space occupation, low cost, and high work efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 This is an overall structural diagram of a simple and retractable mouse inhalation anesthesia device according to an embodiment of the present invention;

[0025] Figure 2 yes Figure 1 perspective drawing;

[0026] Figure 3 yes Figure 1 Exploded view of the anesthetic placement section;

[0027] Figure 4 yes Figure 1 The structural diagram of the anesthesia chamber;

[0028] Figure 5 yes Figure 4 perspective drawing;

[0029] Figure 6 yes Figure 1 The tail base structure diagram in ;

[0030] Figure 7 yes Figure 1 The structure diagram of the surgical fixation plate;

[0031] Figure 8 is a structural diagram of another embodiment of a surgical fixation plate;

[0032] Figure 9 It is a structural diagram of another embodiment of an anesthetic placement unit.

[0033] As shown in the figure:

[0034] 1-Front end interface; 2-Retractable bellows; 3-Tail base; 4-Cone cover; 5-Cylinder; 6-Double valve silicone sleeve; 7-Slide groove; 8-Hollow cylinder; 9-End cover; 10-Snap buckle; 11-Snap buckle groove; 12-Surgical fixation plate; 13-Platform; 14-Fixed frame; 15-Support leg; 16-Air channel interface. DETAILED DESCRIPTION

[0035] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention. Therefore, the following detailed description of the embodiments of the present invention provided in the drawings is not intended to limit the scope of the invention for which protection is claimed, but merely represents selected embodiments of the present invention.

[0036] See also Figure 1 and Figure 2 A simple and retractable mouse inhalation anesthesia device includes an anesthetic placement part, a surgical fixation plate 12 and an anesthesia cabin. The anesthesia cabin includes a front interface 1, a retractable bellows 2 and a tail base 3; the front interface 1 is connected to the front end of the retractable bellows 2 through a conical cover 4, and the rear end of the retractable bellows 2 is provided with a cylinder 5; the tail base 3 is a hollow cylinder, one end of which is nested and connected to the cylinder 5, and the other end is provided with a curling edge, and a double-valve silicone sleeve 6 is sleeved on the curling edge, and the double-valve silicone sleeve 6 is used to seal the anesthesia cabin; the inner wall of the cylinder 5 is provided with two slide grooves 7; the two sides of the surgical fixation plate 12 are respectively matched with the slide grooves 7 so that the surgical fixation plate 12 can be translated in the anesthesia cabin, and the double-valve silicone sleeve 6 is provided with a linear opening corresponding to the surgical fixation plate 12, and the surgical fixation plate 12 can extend out of the anesthesia cabin from the linear opening. The anesthetic placement part includes a hollow cylinder 8 and an end cover 9; one end of the hollow cylinder 8 is closed, and a hollow hole is provided on the closed end. The anesthetic cotton ball is placed in the hollow cylinder 8, and the end cover 9 is provided at the other end of the hollow cylinder 8 for sealing the hollow cylinder 8; the end of the hollow cylinder 8 with the hollow hole is connected to the front end interface 1 of the anesthesia cabin.

[0037] The edges of the surgical fixation plate 12 fit into the grooves 7 on the rear inner wall of the anesthesia chamber. The surgical fixation plate 12 can move axially along the grooves 7, allowing the anesthetized mouse to be pulled out and secured through the linear opening of the double-valve silicone sleeve 6. While securing the mouse, the head or mouth and nose must be kept within the main body of the anesthesia chamber, and the depth of anesthesia can be adjusted by extending and retracting the retractable bellows 2.

[0038] See also Figure 4 and Figure 5 As a preferred embodiment of the present invention, the front-end interface 1 is a cylindrical structure with one end closed, and a hollow hole is provided on the closed end. The hollow cylinder 8 is rotatably connected to the front-end interface 1 of the anesthesia cabin, and the closed ends of the two are in contact. By rotating the cylindrical structure, the size of the overlapping area of ​​the hollow cylinder 8 and the hollow hole in the front-end interface 1 can be adjusted.

[0039] The hollow holes of the two overlap to allow air to flow between the anesthetic placement portion and the anesthesia cabin. When anesthetic is not needed or anesthesia needs to be shallowed, the cylinder 5 is rotated to adjust the depth of anesthesia or close it.

[0040] See also Figure 1 、 Figure 2 、 Figure 4 and Figure 5 As a preferred embodiment of the present invention, the hollow cylindrical body 8 of the anesthetic placement unit is provided with a buckle 10 at its end, and the sidewall of the front interface 1 is provided with an L-shaped buckle slot 11 that mates with the buckle 10 at the end of the hollow cylindrical body 8. The engagement of the buckle 10 with the buckle slot 11 enables a rotational connection between the hollow cylindrical body 8 and the front interface 1 of the anesthesia chamber. The anesthetic cotton ball placement unit rotates counterclockwise in the L-shaped buckle slot 11 via the buckle 10, sealing the air connection between the anesthetic cotton ball placement unit and the anesthesia chamber. When the anesthetic is no longer needed or when anesthesia needs to be reduced, the unit rotates closed, thereby adjusting the depth of anesthesia.

[0041] See also Figure 7 As a preferred embodiment of the present invention, the surgical fixation plate 12 is provided with a 10mm high platform 13 on the side near the front interface 1. The platform 13 has a tooth socket to fix the mouse's incisors. The purpose of this design is to fix the mouse in a prone position.

[0042] See also Figure 8 As a preferred embodiment of the present invention, a fixing frame 14 is provided on the side of the surgical fixation plate 12 near the front interface 1. This fixing frame 14 comprises two upright posts, each connected to a horizontal crossbar at its top, and a U-shaped structure connecting the ends of the two horizontal crossbars. This fixing frame 14 is capable of securing the mouse's incisors. This design is suitable for securing a mouse in a supine position, as the suspended metal rod can hook the mouse's teeth from above.

[0043] See also Figure 1 and Figure 2 As a preferred embodiment of the present invention, two legs 15 are respectively provided under the cone cover 4 and the cylinder 5 to support the simple retractable mouse inhalation anesthesia device to keep it stable.

[0044] The present invention consists of an anesthetic placement unit, an anesthesia cabin, a tail base, and a double-valve silicone sleeve. The main purpose of the present invention is to anesthesia for short and minor surgeries (such as perfusion, orbital blood sampling, etc.). However, in actual use, the device is not limited to short and minor surgical anesthesia. To achieve this purpose, see Figure 9 The end cap 9 is provided with an air circuit interface 16. The air circuit interface 16 allows air to flow into the anesthesia chamber body, thereby increasing the anesthesia time. Compressed air or oxygen can also be introduced into the anesthesia chamber body through the air circuit interface, thereby further increasing the anesthesia time. The air circuit of a gas anesthesia machine, such as an isoflurane gas anesthesia machine, can also be connected to the air circuit interface, thereby realizing the combination of the present invention and the gas anesthesia machine, that is, it can induce anesthesia and achieve long-term stable anesthesia.

[0045] The cone cover 4, cylinder 5, retractable bellows 2, and tail base 3 are all made of transparent materials, so that the operator can see the status of the mouse during the entire operation. Preferably, the cone cover 4, cylinder 5, and tail base 3 are all made of transparent hard plastic.

[0046] See also Figure 2 、 Figure 3 and Figure 9 As a preferred embodiment of the present invention, the hollow cylinder 8 and the hollow holes in the front end interface 1 are six fan-shaped hollow holes of the same size, and the six fan-shaped hollow holes are arranged in a circumferentially evenly distributed manner, so that the area of ​​the overlapping hollow holes in the hollow cylinder 8 and the front end interface 1 can be adjusted by rotating the cylindrical structure.

[0047] When using the simple and retractable mouse inhalation anesthesia device proposed by the present invention, first inject an appropriate amount of isoflurane or other inhalation anesthetics into the center of the cotton ball in the anesthetic cotton ball placement part. After the injection, the anesthetic cotton ball placement part is connected to the anesthesia cabin along the L-shaped snap groove 11, and the anesthetic gas will evaporate into the anesthesia cabin. Rotating the anesthetic cotton ball placement part buckle 10 to the outer end of the L-shaped snap groove 11 counterclockwise can reduce or close the air diffusion with the anesthesia cabin main body, which is used to adjust the anesthetic dosage. Then remove the tail base, directly place the experimental mouse as a whole into the anesthesia cabin main body, and cover the tail base to seal the anesthesia cabin main body to induce anesthesia. In this way, there is no need to fix the mouse when it is awake, and it will not cause a severe stress reaction during anesthesia. Because the entire device is transparent, the mouse's breathing, anesthesia depth, etc. can be observed in real time. After the mouse is induced anesthesia, pull the surgical fixation plate and pull out the anesthetized mouse body through the linear opening of the double-valve silicone sleeve (keeping the mouse's head or mouth and nose in the anesthesia cabin main body). Using forceps, insert the linear opening of the double-valve silicone sleeve 6 to secure the mouse's incisors to the tooth socket, and then further secure the mouse's body according to experimental requirements. During the surgical experiment, the mouse's head or mouth and nose are kept inside the anesthesia chamber (inside the double-valve silicone). The depth of anesthesia is adjusted by rotating the anesthetic placement buckle 10 and retracting the retractable bellows 2, and the depth of anesthesia is determined by observing breathing, heartbeat, and stimulation.

[0048] In addition, the description of the present invention is all for mice. If the experimental animals are replaced with rats, the present invention is also applicable, and only the size of the entire design needs to be adjusted.

[0049] The above descriptions are merely embodiments of the present invention and are not intended to limit the scope of protection of the present invention. Any equivalent structure or equivalent process transformation made using the contents of the present invention description and drawings, or directly or indirectly applied to other related system fields, are also included in the scope of protection of the present invention.

Claims

1. A simple and retractable mouse inhalation anesthesia device, characterized by: It includes an anesthetic placement unit, a surgical fixation plate (12) and an anesthesia cabin; The anesthesia chamber comprises a front end interface (1), a retractable bellows (2) and a rear end base (3); The front end interface (1) is connected to the front end of the telescopic bellows (2) via a conical cover (4), and the rear end of the telescopic bellows (2) is provided with a cylinder (5); the tail base (3) is a hollow cylinder, one end of which is nested and connected to the cylinder (5), and the other end is provided with a curling edge, and a double-valve silicone sleeve (6) is sleeved on the curling edge, and the double-valve silicone sleeve (6) is used to seal the anesthesia cabin; the inner wall of the cylinder (5) is provided with two slide grooves (7); The two sides of the surgical fixation plate (12) cooperate with the slide groove (7) respectively so that the surgical fixation plate (12) can be translated in the anesthesia chamber. The double-valve silicone sleeve (6) is provided with a linear opening corresponding to the surgical fixation plate (12). The surgical fixation plate (12) can extend out of the anesthesia chamber from the linear opening. The tail base (3) can be removed, and the mouse can be placed in and then covered to perform anesthesia. The surgical fixation plate (12) is pulled out and fixed through the linear opening, while the mouse's mouth and nose are kept from extending out of the anesthesia chamber from the linear opening. The depth of anesthesia can be adjusted by extending and retracting the retractable bellows (2). The anesthetic placement portion includes a hollow cylinder (8) and an end cover (9); one end of the hollow cylinder (8) is closed, and a hollow hole is provided on the closed end; the end cover (9) is provided at the other end of the hollow cylinder (8) for sealing the hollow cylinder (8); the end of the hollow cylinder (8) provided with the hollow hole is connected to the front interface (1) of the anesthesia cabin; The conical cover (4), cylinder (5), telescopic bellows (2), and tail base (3) are all made of transparent materials.

2. The simple and retractable mouse inhalation anesthesia device according to claim 1, characterized in that: The front end interface (1) is a cylindrical structure with one end closed, and a hollow hole is provided on the closed end. The hollow cylinder (8) is rotatably connected to the front end interface (1) of the anesthesia cabin, and the closed ends of the two are in contact. By rotating the cylindrical structure, the size of the overlapping area of ​​the hollow hole of the hollow cylinder (8) and the hollow hole of the front end interface (1) can be adjusted.

3. The simple and retractable mouse inhalation anesthesia device according to claim 2, characterized in that: The end of the hollow cylinder (8) of the anesthetic placement portion is provided with a buckle (10), and the side wall of the front end interface (1) is provided with a buckle groove (11) that cooperates with the buckle (10) at the end of the hollow cylinder (8). Through the cooperation between the buckle (10) and the buckle groove (11), the hollow cylinder (8) and the front end interface (1) of the anesthesia cabin are rotatably connected.

4. The simple and retractable mouse inhalation anesthesia device according to claim 3, characterized in that: The surgical fixation plate (12) is provided with a platform (13) on one side close to the front end interface (1), and a tooth socket is provided in the platform (13) to fix the mouse incisors.

5. The simple and retractable mouse inhalation anesthesia device according to claim 3, characterized in that: A fixing frame (14) is provided on one side of the surgical fixing plate (12) close to the front end interface (1). The fixing frame (14) comprises two upright posts, the tops of the two upright posts are respectively connected to a horizontal cross bar, and the other ends of the two horizontal cross bars are respectively connected to the two ends of a U-shaped structure. The fixing frame (14) can fix the mouse incisors.

6. A simple and retractable mouse inhalation anesthesia device according to any one of claims 1 to 5, characterized in that: Two supporting legs (15) are respectively provided below the conical cover (4) and the cylinder (5).

7. A simple and retractable mouse inhalation anesthesia device according to any one of claims 1 to 5, characterized in that: The end cover (9) is provided with a gas path interface (16).

8. The simple and retractable mouse inhalation anesthesia device according to claim 1, characterized in that: The cone cover (4), cylinder (5) and tail base (3) are all made of transparent hard plastic.

9. A simple and retractable mouse inhalation anesthesia device according to any one of claims 1 to 5, characterized in that: The hollow holes of the hollow cylinder (8) and the hollow holes of the front end interface (1) are both six fan-shaped hollow holes.

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