Recombinant rabbit monoclonal antibody of acth, preparation method and application thereof

The screening and preparation of ACTH recombinant rabbit monoclonal antibodies through phage display technology solves the problems of insufficient specificity and sensitivity of ACTH monoclonal antibodies in the existing technology and realizes efficient detection of hypertension-related diseases.

CN116041511BActive Publication Date: 2025-10-10ZHENGZHOU IMMUNO BIOTECH
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Patent Information

Application Number
CN202310142820.3
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-02-21
Publication Date
2025-10-10
Estimated Expiration
2043-02-21

AI Technical Summary

Technical Problem

The existing technology lacks ACTH monoclonal antibodies with strong specificity, high sensitivity and good affinity, which makes the diagnosis of hypertension difficult, especially in adrenal insufficiency and Cushing's syndrome.

Method used

Phage display technology is used to screen and prepare ACTH recombinant rabbit monoclonal antibodies. By designing specific amino acid sequences and FR regions, the specificity and affinity of the antibody are improved. Chemical labels and biological markers are used for coupling and application in the detection of hypertension-related diseases.

Benefits of technology

It provides a recombinant rabbit monoclonal antibody against ACTH with strong specificity, high sensitivity and good affinity, which can stably and accurately detect adrenocorticotropic hormone and improve the accuracy and sensitivity of hypertension diagnosis.

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Abstract

The application relates to the field of antibody technology, in particular to an ACTH recombinant rabbit monoclonal antibody, a preparation method and application thereof. The ACTH recombinant rabbit monoclonal antibody is screened by using phage display technology. The monoclonal antibody has high specificity, high detection sensitivity and good affinity, and solves the problems of low content of adrenocorticotropic hormone in samples and great detection difficulty. Through identification, the monoclonal antibody has good stability and high accuracy when repeatedly detected.
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